MGAT4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1, 4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.69878017
2proline metabolic process (GO:0006560)5.34936334
3regulation of integrin activation (GO:0033623)5.26310365
4embryonic process involved in female pregnancy (GO:0060136)5.06958928
5establishment of apical/basal cell polarity (GO:0035089)4.72540168
6regulation of protein homooligomerization (GO:0032462)4.65155067
7sulfur amino acid catabolic process (GO:0000098)4.44655957
8positive regulation of protein homooligomerization (GO:0032464)4.44058919
9transcription from mitochondrial promoter (GO:0006390)4.40687235
10Golgi transport vesicle coating (GO:0048200)4.12205589
11COPI coating of Golgi vesicle (GO:0048205)4.12205589
12establishment or maintenance of monopolar cell polarity (GO:0061339)4.09516873
13establishment of monopolar cell polarity (GO:0061162)4.09516873
14regulation of early endosome to late endosome transport (GO:2000641)3.94045448
15mitotic G1 DNA damage checkpoint (GO:0031571)3.87365254
16protein localization to endosome (GO:0036010)3.83876852
17negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.75747280
18urea metabolic process (GO:0019627)3.75059899
19urea cycle (GO:0000050)3.72654057
20regulation of hippo signaling (GO:0035330)3.66256443
21apoptotic cell clearance (GO:0043277)3.64994579
22negative regulation of fatty acid biosynthetic process (GO:0045717)3.63684456
23desmosome organization (GO:0002934)3.60662169
24epithelial cell-cell adhesion (GO:0090136)3.59535079
25regulation of cholesterol homeostasis (GO:2000188)3.57058957
26embryonic placenta development (GO:0001892)3.56961342
27regulation of translational fidelity (GO:0006450)3.49052797
28negative regulation of protein oligomerization (GO:0032460)3.48974515
29apoptotic process involved in morphogenesis (GO:0060561)3.46985416
30negative regulation of fatty acid transport (GO:2000192)3.40307151
31hemidesmosome assembly (GO:0031581)3.38899599
32protein retention in ER lumen (GO:0006621)3.38036972
33nitrogen cycle metabolic process (GO:0071941)3.36591761
34mitotic G1/S transition checkpoint (GO:0044819)3.36461813
35anatomical structure regression (GO:0060033)3.34694110
36stress fiber assembly (GO:0043149)3.34518035
37carnitine shuttle (GO:0006853)3.31237507
38oxidative demethylation (GO:0070989)3.24083859
39protein heterotrimerization (GO:0070208)3.21366558
40NADH metabolic process (GO:0006734)3.17101513
41positive regulation of Cdc42 GTPase activity (GO:0043089)3.15567241
42low-density lipoprotein particle clearance (GO:0034383)3.15165123
43glutamine family amino acid biosynthetic process (GO:0009084)3.14579345
44angiotensin maturation (GO:0002003)3.13429727
45fatty acid transmembrane transport (GO:1902001)3.12909600
46G1 DNA damage checkpoint (GO:0044783)3.12827388
47regulation of extracellular matrix disassembly (GO:0010715)3.11358367
48barbed-end actin filament capping (GO:0051016)3.10214129
49hypotonic response (GO:0006971)3.09928918
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.09806880
51negative regulation of fibrinolysis (GO:0051918)3.08582117
52basement membrane organization (GO:0071711)3.06653633
53signal complex assembly (GO:0007172)3.05917702
54positive regulation of protein oligomerization (GO:0032461)3.03885592
55skin morphogenesis (GO:0043589)3.03272509
56maternal placenta development (GO:0001893)3.02818071
57retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.02810095
58mitochondrial DNA metabolic process (GO:0032042)3.02736435
59regulation of podosome assembly (GO:0071801)3.02321696
60regulation of protein oligomerization (GO:0032459)2.99943513
61negative regulation of fatty acid metabolic process (GO:0045922)2.99936504
62glucose 6-phosphate metabolic process (GO:0051156)2.99632345
634-hydroxyproline metabolic process (GO:0019471)2.99323261
64trophectodermal cell differentiation (GO:0001829)2.99312106
65regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.99132357
66negative regulation of JAK-STAT cascade (GO:0046426)2.98820211
67embryonic camera-type eye development (GO:0031076)2.98532382
68adhesion of symbiont to host (GO:0044406)2.97502213
69focal adhesion assembly (GO:0048041)2.96689397
70cell-substrate adherens junction assembly (GO:0007045)2.96689397
71cell adhesion mediated by integrin (GO:0033627)2.95190227
72negative regulation of cell size (GO:0045792)2.94479189
73mannose metabolic process (GO:0006013)2.94319761
74plasma membrane repair (GO:0001778)2.94052843
75regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.92611358
76regulation of glucose import in response to insulin stimulus (GO:2001273)2.90862021
77regulation of cholesterol storage (GO:0010885)2.88152759
78intestinal absorption (GO:0050892)2.85973053
79hormone catabolic process (GO:0042447)2.85502504
80semaphorin-plexin signaling pathway (GO:0071526)2.84015923
81labyrinthine layer development (GO:0060711)2.81904999
82positive regulation of receptor recycling (GO:0001921)2.81414441
83adhesion of symbiont to host cell (GO:0044650)2.81361369
84virion attachment to host cell (GO:0019062)2.81361369
85renal system process involved in regulation of blood volume (GO:0001977)2.80732084
86positive regulation of extracellular matrix organization (GO:1903055)2.79969422
87regulation of cholesterol biosynthetic process (GO:0045540)2.79322872
88peptidyl-glutamic acid carboxylation (GO:0017187)2.78788770
89protein carboxylation (GO:0018214)2.78788770
90cytoskeletal anchoring at plasma membrane (GO:0007016)2.77657703
91branching involved in mammary gland duct morphogenesis (GO:0060444)2.72016367
92epoxygenase P450 pathway (GO:0019373)2.71677856
93very-low-density lipoprotein particle assembly (GO:0034379)2.70472182
94regulation of glomerular filtration (GO:0003093)2.70143032
95cellular response to ATP (GO:0071318)2.69547533
96regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.69296521
97endodermal cell differentiation (GO:0035987)2.68627989
98cellular response to zinc ion (GO:0071294)2.66485770
99regulation of cholesterol metabolic process (GO:0090181)2.66055452
100positive regulation of lamellipodium assembly (GO:0010592)2.64055012
101adherens junction assembly (GO:0034333)2.63663518
102negative regulation of Ras GTPase activity (GO:0034261)2.63027496
103actin filament depolymerization (GO:0030042)2.62702718
104bundle of His cell to Purkinje myocyte communication (GO:0086069)2.62544339
105peptide catabolic process (GO:0043171)2.59416935
106positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.58937496
107amino-acid betaine transport (GO:0015838)2.58204371
108carnitine transport (GO:0015879)2.58204371
109planar cell polarity pathway involved in neural tube closure (GO:0090179)2.57950572
110polarized epithelial cell differentiation (GO:0030859)2.57694156
111glial cell migration (GO:0008347)2.57538079
112glycosphingolipid catabolic process (GO:0046479)2.57482506
113fat-soluble vitamin biosynthetic process (GO:0042362)2.57105630
114response to laminar fluid shear stress (GO:0034616)2.55713516
115regulation of fatty acid beta-oxidation (GO:0031998)2.55559664
116cellular glucuronidation (GO:0052695)2.55302278
117carnitine transmembrane transport (GO:1902603)2.55010304
118pinocytosis (GO:0006907)2.53309026
119positive regulation of triglyceride biosynthetic process (GO:0010867)2.53047931
120negative regulation of glial cell proliferation (GO:0060253)2.52948334
121regulation of fibrinolysis (GO:0051917)2.52741648
122cellular response to lithium ion (GO:0071285)2.51961057
123regulation of extracellular matrix organization (GO:1903053)2.51612627
124lysine metabolic process (GO:0006553)2.50834764
125lysine catabolic process (GO:0006554)2.50834764
126negative regulation of chondrocyte differentiation (GO:0032331)2.49370993
127regulation of hydrogen peroxide-induced cell death (GO:1903205)2.47590020
128regulation of tight junction assembly (GO:2000810)2.47421623
129positive regulation of myotube differentiation (GO:0010831)2.45888748
130vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.45375457
131fatty acid beta-oxidation (GO:0006635)2.45005244
132positive regulation of pseudopodium assembly (GO:0031274)2.43860361
133endocytic recycling (GO:0032456)2.43462357
134activation of Rac GTPase activity (GO:0032863)2.42757922
135nodal signaling pathway (GO:0038092)2.42518640
136peptidyl-proline hydroxylation (GO:0019511)2.42326816
137negative regulation of lipid transport (GO:0032369)2.41989774
138regulation of apoptotic process involved in morphogenesis (GO:1902337)2.41061916
139positive regulation of blood vessel endothelial cell migration (GO:0043536)2.40749675
140regulation of response to reactive oxygen species (GO:1901031)2.40215601
141apoptotic process involved in development (GO:1902742)2.40040334
142negative regulation of heart growth (GO:0061117)2.39748376
143negative regulation of cardiac muscle tissue growth (GO:0055022)2.39748376
144cell-cell junction maintenance (GO:0045217)2.39179707
145glucose catabolic process (GO:0006007)2.38975217
146hyaluronan catabolic process (GO:0030214)2.38903444
147negative regulation of cell cycle arrest (GO:0071157)2.38760589
148positive regulation of lipid catabolic process (GO:0050996)2.38330502
149regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.37829462
150intestinal cholesterol absorption (GO:0030299)2.37428139
151fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.37048900
152glycolipid catabolic process (GO:0019377)2.36468838
153fibrinolysis (GO:0042730)2.36445318
154positive regulation of lamellipodium organization (GO:1902745)2.36271472
155cell-substrate junction assembly (GO:0007044)2.35666011
156negative regulation of focal adhesion assembly (GO:0051895)2.35551987
157negative regulation of cell junction assembly (GO:1901889)2.35551987
158negative regulation of adherens junction organization (GO:1903392)2.35551987
159embryonic eye morphogenesis (GO:0048048)2.35077811
160protein-lipid complex assembly (GO:0065005)2.34963640
161establishment or maintenance of apical/basal cell polarity (GO:0035088)2.34794307
162establishment or maintenance of bipolar cell polarity (GO:0061245)2.34794307
163negative regulation of cartilage development (GO:0061037)2.34733545
164negative regulation of erythrocyte differentiation (GO:0045647)2.34236602
165activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.33878234
166pentose-phosphate shunt (GO:0006098)2.33852426
167regulation of macrophage chemotaxis (GO:0010758)2.33477720
168glucuronate metabolic process (GO:0019585)2.32634305
169uronic acid metabolic process (GO:0006063)2.32634305
170regulation of plasminogen activation (GO:0010755)2.31162624
171membrane protein ectodomain proteolysis (GO:0006509)2.31067138
172regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.30955422
173actin filament bundle organization (GO:0061572)2.26334749

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.12003532
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.10858942
3ZNF263_19887448_ChIP-Seq_K562_Human2.79957014
4* LXR_22292898_ChIP-Seq_THP-1_Human2.68189426
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53139576
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.34408724
7* VDR_21846776_ChIP-Seq_THP-1_Human2.20333633
8* RACK7_27058665_Chip-Seq_MCF-7_Human2.18832059
9* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18828753
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18169524
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.16626393
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09026789
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.06086002
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.04170488
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.02960184
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02616292
17* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96005597
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.95306293
19ERG_21242973_ChIP-ChIP_JURKAT_Human1.92603424
20* KDM2B_26808549_Chip-Seq_DND41_Human1.89677107
21NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.88326085
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.85082573
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81777281
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.80944240
25KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.79675109
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78219744
27* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76282449
28KDM2B_26808549_Chip-Seq_K562_Human1.71955361
29P300_27058665_Chip-Seq_ZR-75-30cells_Human1.71293371
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.70999196
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70360226
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.68509492
33* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.68303656
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67799105
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67252898
36CLOCK_20551151_ChIP-Seq_293T_Human1.67039255
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63386767
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62527845
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60558212
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.58171649
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57840297
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57071790
43MYC_22102868_ChIP-Seq_BL_Human1.55824185
44TCF7_22412390_ChIP-Seq_EML_Mouse1.55291526
45* ATF3_27146783_Chip-Seq_COLON_Human1.55179449
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51088370
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50127239
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49170549
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48533016
50* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47750438
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46742582
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46546663
53* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39777668
54* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39701395
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39687171
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.38589352
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37144179
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36412424
59* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35335757
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35261004
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33727837
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33727837
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33727837
64SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32574276
65* CREB1_26743006_Chip-Seq_LNCaP_Human1.32533593
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30622260
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28198831
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27784374
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.27366207
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26893055
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26211446
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25710073
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.25592412
74* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25143044
75* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21751465
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20797214
77* KDM2B_26808549_Chip-Seq_JURKAT_Human1.20675995
78* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19916501
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.19371366
80P68_20966046_ChIP-Seq_HELA_Human1.19355575
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18407866
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17327175
83BCOR_27268052_Chip-Seq_Bcells_Human1.15583995
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15498074
85* UBF1/2_26484160_Chip-Seq_HMECs_Human1.14853017
86POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14309216
87* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13844981
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13484642
89* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11907047
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11844080
91ESR1_21235772_ChIP-Seq_MCF-7_Human1.10696872
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10648555
93TP53_22127205_ChIP-Seq_IMR90_Human1.10641335
94GATA6_25053715_ChIP-Seq_YYC3_Human1.09270087
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08902066
96NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08823885
97TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08750580
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08251588
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08251588
100DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07282103
101* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05257710
102* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04788275
103NCOR1_26117541_ChIP-Seq_K562_Human1.03699589
104* VDR_24763502_ChIP-Seq_THP-1_Human1.03521341
105* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03078006
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02738032
107EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02608331
108SMC4_20622854_ChIP-Seq_HELA_Human1.02370453
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01606360
110BCL6_27268052_Chip-Seq_Bcells_Human1.01369756
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00681783
112SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00124395
113TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00118658
114PHF8_20622854_ChIP-Seq_HELA_Human0.99920194
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99787402
116* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98974548
117* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98568870
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98379421
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98129508
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98099955
121CTCF_27219007_Chip-Seq_Bcells_Human0.98028925
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.97971773
123SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97667574
124RUNX1_22412390_ChIP-Seq_EML_Mouse0.97489784
125TP63_22573176_ChIP-Seq_HFKS_Human0.97122191
126TBX20_22328084_ChIP-Seq_HEART_Mouse0.96917080
127TBX20_22080862_ChIP-Seq_HEART_Mouse0.96917080
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.96682393
129ELF1_20517297_ChIP-Seq_JURKAT_Human0.96546604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.17119567
2MP0009278_abnormal_bone_marrow3.52405601
3MP0003283_abnormal_digestive_organ3.47562301
4MP0004233_abnormal_muscle_weight2.75405194
5MP0005451_abnormal_body_composition2.68840655
6MP0010352_gastrointestinal_tract_polyps2.48307052
7MP0005058_abnormal_lysosome_morphology2.35232369
8MP0005409_darkened_coat_color2.28355481
9MP0005257_abnormal_intraocular_pressure2.23743252
10MP0010030_abnormal_orbit_morphology2.15090424
11MP0003566_abnormal_cell_adhesion2.11845887
12MP0004130_abnormal_muscle_cell2.10997442
13MP0005076_abnormal_cell_differentiation2.07910504
14MP0000751_myopathy2.05066447
15MP0005171_absent_coat_pigmentation2.01513585
16MP0004264_abnormal_extraembryonic_tissu2.00010233
17MP0010234_abnormal_vibrissa_follicle1.88107337
18MP0009840_abnormal_foam_cell1.83217545
19MP0005167_abnormal_blood-brain_barrier1.80829327
20MP0003300_gastrointestinal_ulcer1.73709089
21MP0004185_abnormal_adipocyte_glucose1.70217574
22MP0005360_urolithiasis1.69319490
23MP0005365_abnormal_bile_salt1.65714645
24MP0008438_abnormal_cutaneous_collagen1.65300596
25MP0003453_abnormal_keratinocyte_physiol1.65155136
26MP0003878_abnormal_ear_physiology1.63444602
27MP0005377_hearing/vestibular/ear_phenot1.63444602
28MP0003191_abnormal_cellular_cholesterol1.63132233
29MP0008260_abnormal_autophagy1.58249731
30MP0005085_abnormal_gallbladder_physiolo1.54738599
31MP0000678_abnormal_parathyroid_gland1.54226207
32MP0003279_aneurysm1.53070784
33MP0002269_muscular_atrophy1.52460086
34MP0003172_abnormal_lysosome_physiology1.52287884
35MP0003045_fibrosis1.52184316
36MP0003567_abnormal_fetal_cardiomyocyte1.51826396
37MP0010368_abnormal_lymphatic_system1.51595682
38MP0001545_abnormal_hematopoietic_system1.49322697
39MP0005397_hematopoietic_system_phenotyp1.49322697
40MP0004087_abnormal_muscle_fiber1.47536726
41MP0005666_abnormal_adipose_tissue1.47096325
42MP0010630_abnormal_cardiac_muscle1.44873215
43MP0000858_altered_metastatic_potential1.41689736
44MP0001849_ear_inflammation1.37652797
45MP0005330_cardiomyopathy1.35089692
46MP0002139_abnormal_hepatobiliary_system1.33369281
47MP0002877_abnormal_melanocyte_morpholog1.33105358
48MP0004858_abnormal_nervous_system1.32713635
49MP0008995_early_reproductive_senescence1.30466352
50MP0004084_abnormal_cardiac_muscle1.29850164
51MP0003183_abnormal_peptide_metabolism1.29145863
52MP0004272_abnormal_basement_membrane1.28614123
53MP0002796_impaired_skin_barrier1.25842059
54MP0005623_abnormal_meninges_morphology1.24857403
55MP0000371_diluted_coat_color1.24011150
56MP0003329_amyloid_beta_deposits1.22237638
57MP0003221_abnormal_cardiomyocyte_apopto1.21318982
58MP0003828_pulmonary_edema1.19277089
59MP0000467_abnormal_esophagus_morphology1.18713059
60MP0002009_preneoplasia1.18129869
61MP0003119_abnormal_digestive_system1.17985580
62MP0005670_abnormal_white_adipose1.16823242
63MP0002086_abnormal_extraembryonic_tissu1.15278312
64MP0005275_abnormal_skin_tensile1.13127889
65MP0004019_abnormal_vitamin_homeostasis1.12914954
66MP0004947_skin_inflammation1.12682672
67MP0000462_abnormal_digestive_system1.12079200
68MP0000566_synostosis1.11805791
69MP0005375_adipose_tissue_phenotype1.10510774
70MP0003075_altered_response_to1.08883547
71MP0001348_abnormal_lacrimal_gland1.08067126
72MP0000490_abnormal_crypts_of1.06877555
73MP0003868_abnormal_feces_composition1.06759741
74MP0009115_abnormal_fat_cell1.06367529
75MP0004197_abnormal_fetal_growth/weight/1.05673635
76MP0001666_abnormal_nutrient_absorption1.04556774
77MP0000767_abnormal_smooth_muscle1.03662598
78MP0009384_cardiac_valve_regurgitation1.02661006
79MP0000750_abnormal_muscle_regeneration1.01858109
80MP0004782_abnormal_surfactant_physiolog1.01610402
81MP0005023_abnormal_wound_healing1.00173377
82MP0002998_abnormal_bone_remodeling0.99422914
83MP0000343_altered_response_to0.99409144
84MP0000477_abnormal_intestine_morphology0.99147799
85MP0008775_abnormal_heart_ventricle0.99082488
86MP0010329_abnormal_lipoprotein_level0.98454043
87MP0003436_decreased_susceptibility_to0.95628763
88MP0002060_abnormal_skin_morphology0.94380394
89MP0000733_abnormal_muscle_development0.94082947
90MP0005319_abnormal_enzyme/_coenzyme0.93264385
91MP0001958_emphysema0.92741765
92MP0003252_abnormal_bile_duct0.91837728
93MP0002653_abnormal_ependyma_morphology0.90983230
94MP0001216_abnormal_epidermal_layer0.88725450
95MP0004510_myositis0.88547856
96MP0009379_abnormal_foot_pigmentation0.88150128
97MP0000609_abnormal_liver_physiology0.87700197
98MP0002098_abnormal_vibrissa_morphology0.86704053
99MP0002282_abnormal_trachea_morphology0.86663072
100MP0006138_congestive_heart_failure0.86465813
101MP0005464_abnormal_platelet_physiology0.86422655
102MP0002971_abnormal_brown_adipose0.86048559
103MP0001664_abnormal_digestion0.85998007
104MP0003091_abnormal_cell_migration0.85749453
105MP0005083_abnormal_biliary_tract0.84886050
106MP0009053_abnormal_anal_canal0.84263641
107MP0000604_amyloidosis0.83939789
108MP0002106_abnormal_muscle_physiology0.83922558
109MP0000747_muscle_weakness0.80956287
110MP0002896_abnormal_bone_mineralization0.79549379
111MP0002118_abnormal_lipid_homeostasis0.78251748
112MP0002084_abnormal_developmental_patter0.77920768
113MP0009643_abnormal_urine_homeostasis0.77658941
114MP0000759_abnormal_skeletal_muscle0.77387675
115MP0002249_abnormal_larynx_morphology0.76781594
116MP0010155_abnormal_intestine_physiology0.76780071
117MP0000537_abnormal_urethra_morphology0.76146614
118MP0005248_abnormal_Harderian_gland0.75825933
119MP0000003_abnormal_adipose_tissue0.75231283
120MP0002089_abnormal_postnatal_growth/wei0.74833642
121MP0003137_abnormal_impulse_conducting0.74243214
122MP0003866_abnormal_defecation0.74193736
123MP0005332_abnormal_amino_acid0.73869560
124MP0003879_abnormal_hair_cell0.73545652
125MP0003303_peritoneal_inflammation0.72966017
126MP0000534_abnormal_ureter_morphology0.72435632
127MP0003448_altered_tumor_morphology0.71945076
128MP0001873_stomach_inflammation0.71924477
129MP0002970_abnormal_white_adipose0.71734513
130MP0005385_cardiovascular_system_phenoty0.71594267
131MP0001544_abnormal_cardiovascular_syste0.71594267
132MP0001915_intracranial_hemorrhage0.70962366
133MP0000762_abnormal_tongue_morphology0.70030751
134MP0009931_abnormal_skin_appearance0.69485687
135MP0005508_abnormal_skeleton_morphology0.69322311
136MP0008961_abnormal_basal_metabolism0.68041620
137MP0005501_abnormal_skin_physiology0.68035570
138MP0000249_abnormal_blood_vessel0.67564797
139MP0005621_abnormal_cell_physiology0.66193799
140MP0001533_abnormal_skeleton_physiology0.64609399
141MP0005165_increased_susceptibility_to0.64591725
142MP0005381_digestive/alimentary_phenotyp0.63271309
143MP0001614_abnormal_blood_vessel0.62918205
144MP0000013_abnormal_adipose_tissue0.62754717
145MP0000538_abnormal_urinary_bladder0.60327377
146MP0001243_abnormal_dermal_layer0.60001340

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)4.00581010
2Turricephaly (HP:0000262)3.92870123
3Mucopolysacchariduria (HP:0008155)3.77927349
4Urinary glycosaminoglycan excretion (HP:0003541)3.77927349
5Alopecia of scalp (HP:0002293)3.69616776
6Asymmetric septal hypertrophy (HP:0001670)3.61135741
7Ulnar bowing (HP:0003031)3.59803565
8Annular pancreas (HP:0001734)3.55551999
9Abnormality of mucopolysaccharide metabolism (HP:0011020)3.41829915
10Abnormality of polysaccharide metabolism (HP:0011012)3.41829915
11Abnormality of glycosaminoglycan metabolism (HP:0004371)3.41829915
12Pustule (HP:0200039)3.35981003
13Vertebral compression fractures (HP:0002953)3.34673550
14Dysostosis multiplex (HP:0000943)3.32496383
15Male infertility (HP:0003251)3.18907266
16Polycythemia (HP:0001901)3.18790775
17Abnormality of monocarboxylic acid metabolism (HP:0010996)3.07407069
18Hemorrhage of the eye (HP:0011885)3.03510159
19Thin bony cortex (HP:0002753)2.96306211
20Right ventricular cardiomyopathy (HP:0011663)2.92582543
21Distal lower limb amyotrophy (HP:0008944)2.82456446
22Vertebral hypoplasia (HP:0008417)2.70920376
23Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.70920376
24Arterial tortuosity (HP:0005116)2.69791295
25Protrusio acetabuli (HP:0003179)2.67940480
26Vascular tortuosity (HP:0004948)2.63976185
27Coronal craniosynostosis (HP:0004440)2.62422043
28Broad face (HP:0000283)2.62000350
29Fragile skin (HP:0001030)2.59218029
30Hypercortisolism (HP:0001578)2.58570340
31Increased connective tissue (HP:0009025)2.56587789
32Difficulty climbing stairs (HP:0003551)2.55145076
33Atrophic scars (HP:0001075)2.51555946
34Lymphangioma (HP:0100764)2.47979066
35Bowed forearm bones (HP:0003956)2.45155503
36Bowing of the arm (HP:0006488)2.45155503
37Abnormality of complement system (HP:0005339)2.44986183
38Short humerus (HP:0005792)2.40952883
39Abnormal hemoglobin (HP:0011902)2.38327330
40Distal upper limb amyotrophy (HP:0007149)2.37558171
41Upper limb amyotrophy (HP:0009129)2.37558171
42Malnutrition (HP:0004395)2.36940338
43Muscle fibrillation (HP:0010546)2.34685422
44Ankle contracture (HP:0006466)2.33151234
45Exercise-induced myalgia (HP:0003738)2.32217766
46Xanthomatosis (HP:0000991)2.30350507
47Systemic lupus erythematosus (HP:0002725)2.30278392
48Flat acetabular roof (HP:0003180)2.28576743
49Distal lower limb muscle weakness (HP:0009053)2.25598927
50Congenital hip dislocation (HP:0001374)2.23054367
51Hand muscle atrophy (HP:0009130)2.22600701
52Disproportionate tall stature (HP:0001519)2.22269412
53Wormian bones (HP:0002645)2.22110430
54Ketoacidosis (HP:0001993)2.20671812
55Growth hormone excess (HP:0000845)2.20055003
56Aneurysm (HP:0002617)2.19288207
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.18479557
58Osteolytic defects of the hand bones (HP:0009699)2.18479557
59Short nail (HP:0001799)2.18470030
60Abdominal distention (HP:0003270)2.18013298
61Poikiloderma (HP:0001029)2.17454873
62Aortic dissection (HP:0002647)2.16534024
63Diaphragmatic weakness (HP:0009113)2.13863262
64Generalized amyotrophy (HP:0003700)2.12237955
65Aortic aneurysm (HP:0004942)2.11320025
66Spinal rigidity (HP:0003306)2.11117557
67Myoglobinuria (HP:0002913)2.10660410
68Joint stiffness (HP:0001387)2.10439985
69Myocardial infarction (HP:0001658)2.10346748
70Concave nail (HP:0001598)2.09989739
71Rib fusion (HP:0000902)2.09638012
72J-shaped sella turcica (HP:0002680)2.06920467
73Vaginal fistula (HP:0004320)2.06710963
74Abnormality of the distal phalanges of the toes (HP:0010182)2.06509804
75Hyperparathyroidism (HP:0000843)2.04476449
76Aplasia/hypoplasia of the humerus (HP:0006507)2.04268223
77Facial hemangioma (HP:0000329)2.03471776
78Bladder diverticulum (HP:0000015)2.02545515
79Abnormality of carpal bone ossification (HP:0006257)2.02420885
80Abnormality of proline metabolism (HP:0010907)2.00876558
81Hydroxyprolinuria (HP:0003080)2.00876558
82Abnormality of the 1st metacarpal (HP:0010009)2.00679475
83Hyporeflexia of lower limbs (HP:0002600)1.99738438
84Mesangial abnormality (HP:0001966)1.98826103
85Esophageal varix (HP:0002040)1.98449835
86Metaphyseal cupping (HP:0003021)1.97323619
87Bilateral sensorineural hearing impairment (HP:0008619)1.95899282
88Mitral regurgitation (HP:0001653)1.94984577
89Choanal stenosis (HP:0000452)1.94393018
90Bone pain (HP:0002653)1.94062673
91Mitral stenosis (HP:0001718)1.93801426
92Abnormality of glutamine family amino acid metabolism (HP:0010902)1.93735648
93Mildly elevated creatine phosphokinase (HP:0008180)1.93596137
94Ventricular tachycardia (HP:0004756)1.93473980
95Sudden death (HP:0001699)1.93074058
96Abnormal ossification of hand bones (HP:0005921)1.93007180
97Focal segmental glomerulosclerosis (HP:0000097)1.92938231
98Multiple lipomas (HP:0001012)1.92921045
99Complement deficiency (HP:0004431)1.92477380
100Shallow orbits (HP:0000586)1.91562297
101Abnormality of the acetabulum (HP:0003170)1.91331525
102Abnormality of the lower motor neuron (HP:0002366)1.89087757
103Tongue fasciculations (HP:0001308)1.88638417
104Hamartoma of the eye (HP:0010568)1.88111942
105Lower limb amyotrophy (HP:0007210)1.85478803
106Axonal loss (HP:0003447)1.84812075
107Stridor (HP:0010307)1.83112602
108Hyperacusis (HP:0010780)1.82798050
109Dilatation of the ascending aorta (HP:0005111)1.82453951
110Difficulty running (HP:0009046)1.81882498
111Gastrointestinal dysmotility (HP:0002579)1.81396305
112Abnormality of the Achilles tendon (HP:0005109)1.80872824
113Asymmetry of the thorax (HP:0001555)1.80361529
114Achilles tendon contracture (HP:0001771)1.79923915
115Increased mean platelet volume (HP:0011877)1.79377977
116Short phalanx of the thumb (HP:0009660)1.79251052
117Premature rupture of membranes (HP:0001788)1.79232905
118Coxa vara (HP:0002812)1.78957154
119Deep venous thrombosis (HP:0002625)1.78170156
120Advanced eruption of teeth (HP:0006288)1.77710986
121Large for gestational age (HP:0001520)1.77286288
122Increased CSF protein (HP:0002922)1.77152946
123Abnormality of the aortic arch (HP:0012303)1.77010831
124Natal tooth (HP:0000695)1.76942333
125Elbow flexion contracture (HP:0002987)1.76573073
126Neonatal short-limb short stature (HP:0008921)1.76217265
127Mitral valve prolapse (HP:0001634)1.76022840
128Hypochromic microcytic anemia (HP:0004840)1.75985009
129Back pain (HP:0003418)1.75193832
130Rectal fistula (HP:0100590)1.73922580
131Rectovaginal fistula (HP:0000143)1.73922580
132Cardiovascular calcification (HP:0011915)1.73848046
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.72748021
134Neonatal death (HP:0003811)1.72322296
135Increased variability in muscle fiber diameter (HP:0003557)1.71105927
136Genu recurvatum (HP:0002816)1.70939133
137Biconcave vertebral bodies (HP:0004586)1.70542855
138Bulbar palsy (HP:0001283)1.70160354
139Long palpebral fissure (HP:0000637)1.69970517
140Cerebral inclusion bodies (HP:0100314)1.69182621
141Rectal prolapse (HP:0002035)1.69103226
142Cervical subluxation (HP:0003308)1.68403683
143Ketosis (HP:0001946)1.68105507
144Premature skin wrinkling (HP:0100678)1.68043778
145Obstructive sleep apnea (HP:0002870)1.67993964
146Congenital glaucoma (HP:0001087)1.67540869
147Vertebral clefting (HP:0008428)1.67279372
148Visceral angiomatosis (HP:0100761)1.67158532
149Conjugated hyperbilirubinemia (HP:0002908)1.66949808
150Abnormal platelet volume (HP:0011876)1.66736856
151Blue sclerae (HP:0000592)1.66583150
152Bundle branch block (HP:0011710)1.66191931
153Hyperammonemia (HP:0001987)1.66162462
154Polygenic inheritance (HP:0010982)1.65595550
155Ileus (HP:0002595)1.65396244
156Centrally nucleated skeletal muscle fibers (HP:0003687)1.65250627
157Coarse hair (HP:0002208)1.64912498
158Cupped ribs (HP:0000887)1.64707242
159Fasciculations (HP:0002380)1.64690781
160Broad metatarsal (HP:0001783)1.64542568
161Hamartoma (HP:0010566)1.64330360
162Abnormality of the thoracic spine (HP:0100711)1.64025582
163Vascular calcification (HP:0004934)1.62136367
164Trismus (HP:0000211)1.60470470
165Abnormality of glycolipid metabolism (HP:0010969)1.60370027
166Abnormality of glycosphingolipid metabolism (HP:0004343)1.60370027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.57478047
2TRIB34.36478580
3DDR24.14551318
4IRAK33.45072963
5MAP3K62.92987643
6PKN22.90216385
7SMG12.65249258
8MAPK152.60494413
9MAP3K112.58824567
10TYRO32.57448296
11PRPF4B2.54768500
12PDGFRA2.48521769
13BMX2.26883425
14MATK2.20201191
15RIPK12.16077521
16ERN12.03175511
17MST1R1.70344987
18FGR1.66995601
19MAP3K101.64705237
20PHKG11.63632072
21PHKG21.63632072
22LATS21.54328601
23PRKD21.51659924
24TESK11.50881418
25PINK11.50104926
26TTN1.49042530
27DYRK1B1.45553690
28DAPK11.43616293
29CSK1.42341441
30PIM21.41788379
31MAP3K31.40857288
32NME21.39539272
33NTRK11.39058654
34EEF2K1.36788605
35CDK61.36202076
36PTK61.33020879
37LMTK21.15697198
38EPHB21.14016962
39DMPK1.12657071
40PAK41.06643045
41TAOK11.02116073
42PTK21.01769672
43TRPM71.00744412
44PDPK11.00150725
45MAP2K20.93803703
46LATS10.93047904
47RPS6KA20.92479872
48ARAF0.92281196
49NEK10.91610979
50MTOR0.89481861
51EPHA20.88940411
52TESK20.88037696
53LRRK20.87193682
54IRAK20.87027760
55GSK3A0.84181904
56MYLK0.84108163
57MAP3K90.83715712
58SIK10.82606455
59MAPK110.82038620
60UHMK10.81835482
61SCYL20.81426635
62MAP3K130.80847708
63CDC42BPA0.80231153
64ILK0.79939465
65KSR20.79439413
66BCKDK0.76658400
67RPS6KL10.76414817
68RPS6KC10.76414817
69CDK70.75502606
70MAPKAPK30.74620687
71MET0.72824883
72PRKD30.72770637
73MARK20.70369020
74STK380.68575936
75ZAP700.66612773
76PRKG20.66458567
77PAK20.65421084
78PRKAA10.65400243
79RPS6KA60.64417417
80TGFBR20.63771109
81PDGFRB0.62910495
82MAP3K80.60328382
83RPS6KA10.60227076
84IRAK40.59322888
85EPHB10.58778310
86TIE10.57763647
87RET0.55448538
88CAMK1D0.55027944
89MAP3K70.53983812
90CAMKK10.53894105
91PIM10.53166709
92LIMK10.50144507
93MAP2K10.49001866
94MOS0.48846305
95RPS6KB20.48603634
96NEK90.48347060
97EGFR0.48069257
98TYK20.47174642
99BRAF0.46915445
100ALK0.46167829
101KDR0.45870841
102ABL20.45232001
103ERBB40.45054607
104PRKAA20.43506431
105STK240.43485032
106GRK60.43143941
107FLT30.42575971
108PDK10.42416454
109JAK30.42393477
110DAPK20.41841213
111DAPK30.40874924
112PRKD10.40529067
113MAP2K30.40251360
114HIPK20.39498361
115RAF10.39437343
116FER0.39109976
117MELK0.38524735
118PAK60.38308530
119FGFR30.37112814
120CDK80.37064886
121FGFR40.36562127
122MAPKAPK20.35603830
123MAP3K140.35282563
124CDK120.35234502
125TBK10.32153472
126PRKCI0.31857701
127CDK90.31564681
128PDK40.30776884
129PDK30.30776884
130FGFR10.30757685
131ROCK20.30663508
132SIK30.29290182
133STK38L0.29137843
134TAOK20.28862377
135CDK40.28389770
136MAP3K20.27675980
137AKT20.27654402
138MAP3K10.26733704
139JAK20.25788373

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.70712299
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.02325650
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.90930268
4Other glycan degradation_Homo sapiens_hsa005112.67479754
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.65277717
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.32782316
7Fatty acid metabolism_Homo sapiens_hsa012122.22086252
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90660927
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79675222
10Arginine biosynthesis_Homo sapiens_hsa002201.78845561
11mTOR signaling pathway_Homo sapiens_hsa041501.76322576
12Fatty acid degradation_Homo sapiens_hsa000711.74559835
13Adherens junction_Homo sapiens_hsa045201.68403023
14Bladder cancer_Homo sapiens_hsa052191.66612636
15Sulfur relay system_Homo sapiens_hsa041221.65613410
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.59691219
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58026317
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.54490224
19Renin-angiotensin system_Homo sapiens_hsa046141.51087517
20Nitrogen metabolism_Homo sapiens_hsa009101.50551611
21PPAR signaling pathway_Homo sapiens_hsa033201.50387956
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50387147
23VEGF signaling pathway_Homo sapiens_hsa043701.48277802
24Pentose phosphate pathway_Homo sapiens_hsa000301.42006699
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41818205
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40376010
27Complement and coagulation cascades_Homo sapiens_hsa046101.38649448
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35333351
29Biosynthesis of amino acids_Homo sapiens_hsa012301.34902327
30Prion diseases_Homo sapiens_hsa050201.34861502
31Fat digestion and absorption_Homo sapiens_hsa049751.34732065
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32351391
33Longevity regulating pathway - mammal_Homo sapiens_hsa042111.31900421
34Notch signaling pathway_Homo sapiens_hsa043301.29385921
35Hippo signaling pathway_Homo sapiens_hsa043901.27668813
36Bile secretion_Homo sapiens_hsa049761.25705065
37Chronic myeloid leukemia_Homo sapiens_hsa052201.25434230
38Focal adhesion_Homo sapiens_hsa045101.24047647
39Arginine and proline metabolism_Homo sapiens_hsa003301.21697176
40Lysine degradation_Homo sapiens_hsa003101.20488793
41Carbon metabolism_Homo sapiens_hsa012001.18213381
42Propanoate metabolism_Homo sapiens_hsa006401.14207244
43Vitamin digestion and absorption_Homo sapiens_hsa049771.13978227
44Tight junction_Homo sapiens_hsa045301.12810631
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.10730728
46Insulin signaling pathway_Homo sapiens_hsa049101.10405203
47Caffeine metabolism_Homo sapiens_hsa002321.10203405
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08329889
49AMPK signaling pathway_Homo sapiens_hsa041521.06928093
50Fructose and mannose metabolism_Homo sapiens_hsa000511.06438129
51Small cell lung cancer_Homo sapiens_hsa052221.05061548
52Phenylalanine metabolism_Homo sapiens_hsa003601.03791195
53Proteoglycans in cancer_Homo sapiens_hsa052051.03055497
54Viral myocarditis_Homo sapiens_hsa054161.02255859
55Retinol metabolism_Homo sapiens_hsa008301.01576085
56Sulfur metabolism_Homo sapiens_hsa009200.95306775
57Endometrial cancer_Homo sapiens_hsa052130.94869394
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94560851
59Hedgehog signaling pathway_Homo sapiens_hsa043400.93461014
60Galactose metabolism_Homo sapiens_hsa000520.92825549
61Starch and sucrose metabolism_Homo sapiens_hsa005000.89748072
62Histidine metabolism_Homo sapiens_hsa003400.88841202
63Insulin resistance_Homo sapiens_hsa049310.85746997
64Shigellosis_Homo sapiens_hsa051310.85573391
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.84975599
66Amoebiasis_Homo sapiens_hsa051460.84864786
67Mineral absorption_Homo sapiens_hsa049780.84863377
68Pyruvate metabolism_Homo sapiens_hsa006200.83927664
69ECM-receptor interaction_Homo sapiens_hsa045120.81864157
70Renal cell carcinoma_Homo sapiens_hsa052110.81236991
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80878090
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.80570075
73Chemical carcinogenesis_Homo sapiens_hsa052040.80402638
74Glycerolipid metabolism_Homo sapiens_hsa005610.79527730
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78926562
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78645080
77Butanoate metabolism_Homo sapiens_hsa006500.78476318
78Hepatitis C_Homo sapiens_hsa051600.77612068
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75723427
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75703142
81Acute myeloid leukemia_Homo sapiens_hsa052210.75457969
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74876610
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74367386
84Lysosome_Homo sapiens_hsa041420.74065735
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73967395
86Thyroid cancer_Homo sapiens_hsa052160.72098453
87Tryptophan metabolism_Homo sapiens_hsa003800.71174215
88Dorso-ventral axis formation_Homo sapiens_hsa043200.70556878
89Vitamin B6 metabolism_Homo sapiens_hsa007500.70418277
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68169147
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67517568
92TGF-beta signaling pathway_Homo sapiens_hsa043500.67369358
93Gap junction_Homo sapiens_hsa045400.67115524
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66379370
95Colorectal cancer_Homo sapiens_hsa052100.65331570
96Protein digestion and absorption_Homo sapiens_hsa049740.65152626
97Tyrosine metabolism_Homo sapiens_hsa003500.62583579
98Dilated cardiomyopathy_Homo sapiens_hsa054140.61097007
99Vibrio cholerae infection_Homo sapiens_hsa051100.61049536
100Sphingolipid metabolism_Homo sapiens_hsa006000.60567098
101Estrogen signaling pathway_Homo sapiens_hsa049150.59588515
102Glioma_Homo sapiens_hsa052140.59424821
103Pancreatic cancer_Homo sapiens_hsa052120.59369449
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56369391
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.56367726
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56339413
107TNF signaling pathway_Homo sapiens_hsa046680.54890385
108Circadian rhythm_Homo sapiens_hsa047100.54096448
109HIF-1 signaling pathway_Homo sapiens_hsa040660.53813018
110Toxoplasmosis_Homo sapiens_hsa051450.53630167
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53270516
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52678157
113ErbB signaling pathway_Homo sapiens_hsa040120.52385166
114Apoptosis_Homo sapiens_hsa042100.52156788
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51588326
116Pertussis_Homo sapiens_hsa051330.51343151
117Salmonella infection_Homo sapiens_hsa051320.50173599
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50110134
119Base excision repair_Homo sapiens_hsa034100.50017844
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49995712
121Choline metabolism in cancer_Homo sapiens_hsa052310.49645519
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.48919026
123Prostate cancer_Homo sapiens_hsa052150.47702097
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47675592
125MicroRNAs in cancer_Homo sapiens_hsa052060.47406707
126Basal cell carcinoma_Homo sapiens_hsa052170.46654323
127Glutathione metabolism_Homo sapiens_hsa004800.45645134
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44318169
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44082396
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.43990917
131GnRH signaling pathway_Homo sapiens_hsa049120.42562492
132Endocytosis_Homo sapiens_hsa041440.42237339
133Non-small cell lung cancer_Homo sapiens_hsa052230.41249965
134beta-Alanine metabolism_Homo sapiens_hsa004100.39115069
135Rap1 signaling pathway_Homo sapiens_hsa040150.39105755

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »