ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nonmotile primary cilium assembly (GO:0035058)	7.93537855
2	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	7.15096553
3	substrate-independent telencephalic tangential migration (GO:0021826)	7.15096553
4	left/right axis specification (GO:0070986)	6.03848665
5	indolalkylamine metabolic process (GO:0006586)	5.97701021
6	somite development (GO:0061053)	5.43049383
7	behavioral response to nicotine (GO:0035095)	4.74378720
8	indole-containing compound catabolic process (GO:0042436)	4.63561345
9	indolalkylamine catabolic process (GO:0046218)	4.63561345
10	tryptophan catabolic process (GO:0006569)	4.63561345
11	DNA deamination (GO:0045006)	4.54417895
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.46136409
13	kynurenine metabolic process (GO:0070189)	4.43909628
14	detection of light stimulus involved in visual perception (GO:0050908)	4.31856967
15	detection of light stimulus involved in sensory perception (GO:0050962)	4.31856967
16	regulation of cilium movement (GO:0003352)	4.29377956
17	tryptophan metabolic process (GO:0006568)	4.27023397
18	indole-containing compound metabolic process (GO:0042430)	4.10168900
19	photoreceptor cell maintenance (GO:0045494)	3.86613904
20	piRNA metabolic process (GO:0034587)	3.71615688
21	retinal cone cell development (GO:0046549)	3.69233254
22	axoneme assembly (GO:0035082)	3.65492596
23	epithelial cilium movement (GO:0003351)	3.64805880
24	L-fucose catabolic process (GO:0042355)	3.61148440
25	fucose catabolic process (GO:0019317)	3.61148440
26	L-fucose metabolic process (GO:0042354)	3.61148440
27	platelet dense granule organization (GO:0060155)	3.60088752
28	photoreceptor cell development (GO:0042461)	3.57906586
29	neuronal action potential propagation (GO:0019227)	3.51851228
30	negative regulation of telomere maintenance (GO:0032205)	3.51143686
31	eye photoreceptor cell development (GO:0042462)	3.41588876
32	response to pheromone (GO:0019236)	3.38609358
33	S-adenosylmethionine metabolic process (GO:0046500)	3.35254065
34	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.32332817
35	cellular biogenic amine catabolic process (GO:0042402)	3.31385694
36	amine catabolic process (GO:0009310)	3.31385694
37	aldehyde catabolic process (GO:0046185)	3.24081018
38	retinal rod cell development (GO:0046548)	3.20047879
39	cilium movement (GO:0003341)	3.09602199
40	positive regulation of defense response to virus by host (GO:0002230)	3.05234780
41	cornea development in camera-type eye (GO:0061303)	3.04709812
42	behavioral response to ethanol (GO:0048149)	2.98622031
43	serotonin metabolic process (GO:0042428)	2.98138004
44	regulation of memory T cell differentiation (GO:0043380)	2.95768495
45	regulation of MHC class I biosynthetic process (GO:0045343)	2.91679624
46	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.91484190
47	cilium or flagellum-dependent cell motility (GO:0001539)	2.88162303
48	sulfate transport (GO:0008272)	2.87819388
49	serine family amino acid catabolic process (GO:0009071)	2.85734354
50	negative regulation of response to food (GO:0032096)	2.85346390
51	negative regulation of appetite (GO:0032099)	2.85346390
52	primary amino compound metabolic process (GO:1901160)	2.83170951
53	ubiquinone biosynthetic process (GO:0006744)	2.83092606
54	iron-sulfur cluster assembly (GO:0016226)	2.77445197
55	metallo-sulfur cluster assembly (GO:0031163)	2.77445197
56	DNA methylation involved in gamete generation (GO:0043046)	2.76800827
57	aromatic amino acid family metabolic process (GO:0009072)	2.75782121
58	regulation of protein glycosylation (GO:0060049)	2.74984731
59	cilium organization (GO:0044782)	2.73635470
60	cilium morphogenesis (GO:0060271)	2.70848659
61	valine metabolic process (GO:0006573)	2.70585992
62	regulation of microtubule-based movement (GO:0060632)	2.70578873
63	cytidine deamination (GO:0009972)	2.70140189
64	cytidine metabolic process (GO:0046087)	2.70140189
65	cytidine catabolic process (GO:0006216)	2.70140189
66	tongue development (GO:0043586)	2.70017338
67	reciprocal meiotic recombination (GO:0007131)	2.68260855
68	reciprocal DNA recombination (GO:0035825)	2.68260855
69	cilium assembly (GO:0042384)	2.67277883
70	sulfate transmembrane transport (GO:1902358)	2.66456547
71	sulfation (GO:0051923)	2.66211333
72	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.63768010
73	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.58954854
74	regulation of telomere maintenance (GO:0032204)	2.57520764
75	aromatic amino acid family catabolic process (GO:0009074)	2.57387743
76	synaptic transmission, cholinergic (GO:0007271)	2.56781402
77	estrogen biosynthetic process (GO:0006703)	2.56685859
78	protein-cofactor linkage (GO:0018065)	2.56422340
79	establishment of protein localization to Golgi (GO:0072600)	2.53943306
80	benzene-containing compound metabolic process (GO:0042537)	2.53544441
81	brain morphogenesis (GO:0048854)	2.52947133
82	neural tube formation (GO:0001841)	2.52200708
83	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.51452508
84	neuronal action potential (GO:0019228)	2.50057921
85	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.49556568
86	signal peptide processing (GO:0006465)	2.48687180
87	transepithelial transport (GO:0070633)	2.46103024
88	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.45806121
89	branched-chain amino acid catabolic process (GO:0009083)	2.45627974
90	ubiquinone metabolic process (GO:0006743)	2.45400409
91	inositol phosphate catabolic process (GO:0071545)	2.45254808
92	hematopoietic stem cell differentiation (GO:0060218)	2.45239213
93	methionine biosynthetic process (GO:0009086)	2.45232281
94	acrosome reaction (GO:0007340)	2.44784012
95	positive regulation of interleukin-1 secretion (GO:0050716)	2.44481012
96	regulation of action potential (GO:0098900)	2.43519260
97	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.43499022
98	regulation of interleukin-1 beta secretion (GO:0050706)	2.43308789
99	protein targeting to Golgi (GO:0000042)	2.40250678
100	neuron cell-cell adhesion (GO:0007158)	2.40207423

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.26935337
2	VDR_22108803_ChIP-Seq_LS180_Human	3.90729618
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.59089216
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.89126818
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.84436832
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.38029098
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.32114114
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.25008786
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.19599486
10	P300_19829295_ChIP-Seq_ESCs_Human	2.00557781
11	FUS_26573619_Chip-Seq_HEK293_Human	1.99310264
12	BCAT_22108803_ChIP-Seq_LS180_Human	1.98278086
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.92316979
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.89458595
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.88579796
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.82808075
17	IRF1_19129219_ChIP-ChIP_H3396_Human	1.82580228
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.82437221
19	EWS_26573619_Chip-Seq_HEK293_Human	1.73036766
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.71638818
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.70078344
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.67932470
23	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.67614141
24	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.67516050
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.63688570
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60326109
27	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.59492732
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.57711510
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57711510
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.57101323
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.57075449
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.56963183
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52797565
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51465970
35	STAT3_23295773_ChIP-Seq_U87_Human	1.49808358
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.48925065
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44772737
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44772737
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40497399
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40133067
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.39987546
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.39797516
43	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.38886486
44	TCF4_23295773_ChIP-Seq_U87_Human	1.38662778
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.37488693
46	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.37025698
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35565484
48	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.34213437
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.33480542
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32305890
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32305890
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32176918
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32176918
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.31979755
55	AR_25329375_ChIP-Seq_VCAP_Human	1.31667253
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31430895
57	NCOR_22424771_ChIP-Seq_293T_Human	1.28760898
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28667676
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27548479
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.24913197
61	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.23765717
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23647884
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17976368
64	AR_20517297_ChIP-Seq_VCAP_Human	1.17603361
65	MYC_18940864_ChIP-ChIP_HL60_Human	1.17407063
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15735195
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13681215
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11991807
69	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.11666426
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10781641
71	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10021510
72	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.09110744
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.08628653
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07841907
75	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.07201236
76	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05329988
77	CDX2_22108803_ChIP-Seq_LS180_Human	1.05097169
78	HTT_18923047_ChIP-ChIP_STHdh_Human	1.03711638
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02778478
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02668864
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01506494
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01419171
83	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01285810
84	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00608481
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00225709
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99839811
87	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.99054883
88	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98817170
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98564474
90	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97753598
91	OCT4_20526341_ChIP-Seq_ESCs_Human	0.95940612
92	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95238164
93	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95166783
94	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.95033733
95	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94871037
96	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.94349388
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.94075104
98	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94048661
99	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.92639451
100	ETV1_20927104_ChIP-Seq_GIST48_Human	0.91442683

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.27313683
2	MP0006292_abnormal_olfactory_placode	3.35064427
3	MP0003787_abnormal_imprinting	3.33665642
4	MP0008877_abnormal_DNA_methylation	3.29841204
5	MP0005551_abnormal_eye_electrophysiolog	2.68904500
6	MP0001968_abnormal_touch/_nociception	2.37104172
7	MP0005174_abnormal_tail_pigmentation	2.37011241
8	MP0005646_abnormal_pituitary_gland	2.36093143
9	MP0008789_abnormal_olfactory_epithelium	2.34211616
10	MP0002736_abnormal_nociception_after	2.22624995
11	MP0001501_abnormal_sleep_pattern	2.17813064
12	MP0002876_abnormal_thyroid_physiology	2.15121888
13	MP0002102_abnormal_ear_morphology	2.13400197
14	MP0006072_abnormal_retinal_apoptosis	2.10706371
15	MP0002254_reproductive_system_inflammat	2.06859577
16	MP0001984_abnormal_olfaction	1.94846908
17	MP0005253_abnormal_eye_physiology	1.88887876
18	MP0005360_urolithiasis	1.86898489
19	MP0003195_calcinosis	1.82654502
20	MP0000427_abnormal_hair_cycle	1.80119950
21	MP0006276_abnormal_autonomic_nervous	1.74376020
22	MP0005083_abnormal_biliary_tract	1.73123269
23	MP0002234_abnormal_pharynx_morphology	1.66386901
24	MP0002095_abnormal_skin_pigmentation	1.65130886
25	MP0005499_abnormal_olfactory_system	1.62362041
26	MP0005394_taste/olfaction_phenotype	1.62362041
27	MP0000372_irregular_coat_pigmentation	1.55268213
28	MP0005645_abnormal_hypothalamus_physiol	1.54798972
29	MP0009745_abnormal_behavioral_response	1.53144545
30	MP0001986_abnormal_taste_sensitivity	1.51844611
31	MP0003880_abnormal_central_pattern	1.51438706
32	MP0008872_abnormal_physiological_respon	1.50958295
33	MP0001529_abnormal_vocalization	1.48409345
34	MP0008875_abnormal_xenobiotic_pharmacok	1.48076952
35	MP0005084_abnormal_gallbladder_morpholo	1.45465662
36	MP0003646_muscle_fatigue	1.44564059
37	MP0003718_maternal_effect	1.36316576
38	MP0009046_muscle_twitch	1.30903474
39	MP0000015_abnormal_ear_pigmentation	1.29609441
40	MP0000383_abnormal_hair_follicle	1.27433236
41	MP0010386_abnormal_urinary_bladder	1.26749815
42	MP0002272_abnormal_nervous_system	1.24712245
43	MP0002638_abnormal_pupillary_reflex	1.21279965
44	MP0005171_absent_coat_pigmentation	1.20639782
45	MP0003121_genomic_imprinting	1.18883811
46	MP0002938_white_spotting	1.18404231
47	MP0001293_anophthalmia	1.18396621
48	MP0003878_abnormal_ear_physiology	1.14661824
49	MP0005377_hearing/vestibular/ear_phenot	1.14661824
50	MP0003252_abnormal_bile_duct	1.13930088
51	MP0003122_maternal_imprinting	1.13109556
52	MP0001324_abnormal_eye_pigmentation	1.12267705
53	MP0004145_abnormal_muscle_electrophysio	1.12094533
54	MP0002734_abnormal_mechanical_nocicepti	1.09724429
55	MP0004142_abnormal_muscle_tone	1.08374713
56	MP0001764_abnormal_homeostasis	1.07997786
57	MP0002163_abnormal_gland_morphology	1.06296554
58	MP0005410_abnormal_fertilization	1.06268275
59	MP0005310_abnormal_salivary_gland	1.03667041
60	MP0005195_abnormal_posterior_eye	0.99672962
61	MP0001502_abnormal_circadian_rhythm	0.99608358
62	MP0001905_abnormal_dopamine_level	0.99590802
63	MP0002557_abnormal_social/conspecific_i	0.98705773
64	MP0004147_increased_porphyrin_level	0.97552093
65	MP0001970_abnormal_pain_threshold	0.96495246
66	MP0009379_abnormal_foot_pigmentation	0.96060307
67	MP0002653_abnormal_ependyma_morphology	0.94614367
68	MP0005075_abnormal_melanosome_morpholog	0.93200626
69	MP0002837_dystrophic_cardiac_calcinosis	0.93059644
70	MP0001486_abnormal_startle_reflex	0.91699238
71	MP0000613_abnormal_salivary_gland	0.91403708
72	MP0005085_abnormal_gallbladder_physiolo	0.90757220
73	MP0005379_endocrine/exocrine_gland_phen	0.88480568
74	MP0002572_abnormal_emotion/affect_behav	0.88215905
75	MP0000647_abnormal_sebaceous_gland	0.87595998
76	MP0000631_abnormal_neuroendocrine_gland	0.87505153
77	MP0000371_diluted_coat_color	0.86797157
78	MP0002752_abnormal_somatic_nervous	0.83751503
79	MP0010329_abnormal_lipoprotein_level	0.81657637
80	MP0005389_reproductive_system_phenotype	0.81103491
81	MP0004043_abnormal_pH_regulation	0.80184135
82	MP0002160_abnormal_reproductive_system	0.79554975
83	MP0005636_abnormal_mineral_homeostasis	0.78612275
84	MP0002067_abnormal_sensory_capabilities	0.78592077
85	MP0003011_delayed_dark_adaptation	0.78514243
86	MP0004133_heterotaxia	0.78035813
87	MP0002733_abnormal_thermal_nociception	0.77542940
88	MP0002064_seizures	0.77018862
89	MP0002735_abnormal_chemical_nociception	0.71686659
90	MP0001661_extended_life_span	0.71637517
91	MP0002090_abnormal_vision	0.71516032
92	MP0005391_vision/eye_phenotype	0.70899402
93	MP0002282_abnormal_trachea_morphology	0.70628007
94	MP0003698_abnormal_male_reproductive	0.70478411
95	MP0004885_abnormal_endolymph	0.68962824
96	MP0004924_abnormal_behavior	0.67060513
97	MP0005386_behavior/neurological_phenoty	0.67060513
98	MP0002233_abnormal_nose_morphology	0.67051824
99	MP0003186_abnormal_redox_activity	0.66345313
100	MP0001270_distended_abdomen	0.64288463

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	5.76169478
2	Molar tooth sign on MRI (HP:0002419)	5.76169478
3	Pancreatic fibrosis (HP:0100732)	4.88731574
4	Pancreatic cysts (HP:0001737)	4.12870766
5	True hermaphroditism (HP:0010459)	3.81546354
6	Type II lissencephaly (HP:0007260)	3.62766626
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.57209852
8	Keratoconus (HP:0000563)	3.52023950
9	Increased corneal curvature (HP:0100692)	3.52023950
10	Pendular nystagmus (HP:0012043)	3.47224616
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.46838992
12	Congenital stationary night blindness (HP:0007642)	3.24185036
13	Severe visual impairment (HP:0001141)	3.19784912
14	Medial flaring of the eyebrow (HP:0010747)	3.15971539
15	Attenuation of retinal blood vessels (HP:0007843)	3.12385613
16	Nephronophthisis (HP:0000090)	3.08163801
17	Abolished electroretinogram (ERG) (HP:0000550)	3.04787602
18	Gaze-evoked nystagmus (HP:0000640)	3.00176664
19	Abnormality of the renal medulla (HP:0100957)	2.97559158
20	Cystic liver disease (HP:0006706)	2.87907654
21	Hyperventilation (HP:0002883)	2.85561721
22	Chronic hepatic failure (HP:0100626)	2.80954399
23	Abnormality of the renal cortex (HP:0011035)	2.80457272
24	Anencephaly (HP:0002323)	2.80106279
25	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.75113759
26	Congenital primary aphakia (HP:0007707)	2.58507364
27	Gait imbalance (HP:0002141)	2.57492235
28	Postaxial foot polydactyly (HP:0001830)	2.55386654
29	Congenital hepatic fibrosis (HP:0002612)	2.48251506
30	Oculomotor apraxia (HP:0000657)	2.45894006
31	Nephrogenic diabetes insipidus (HP:0009806)	2.44543665
32	Decreased central vision (HP:0007663)	2.42061849
33	Bony spicule pigmentary retinopathy (HP:0007737)	2.40658448
34	Progressive cerebellar ataxia (HP:0002073)	2.37665356
35	Inability to walk (HP:0002540)	2.34762170
36	Short middle phalanx of the 5th finger (HP:0004220)	2.34662081
37	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.32689653
38	Abnormal respiratory motile cilium physiology (HP:0012261)	2.32074570
39	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.28508092
40	Retinal dysplasia (HP:0007973)	2.25701475
41	Abnormal biliary tract physiology (HP:0012439)	2.22468924
42	Bile duct proliferation (HP:0001408)	2.22468924
43	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.21215265
44	Abnormal drinking behavior (HP:0030082)	2.19138865
45	Polydipsia (HP:0001959)	2.19138865
46	Focal motor seizures (HP:0011153)	2.18674583
47	Abnormality of macular pigmentation (HP:0008002)	2.17549690
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.12435601
49	Absent/shortened dynein arms (HP:0200106)	2.12435601
50	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.11728374
51	Homocystinuria (HP:0002156)	2.10651891
52	Abnormality of homocysteine metabolism (HP:0010919)	2.10651891
53	Sclerocornea (HP:0000647)	2.10131518
54	Abnormal respiratory epithelium morphology (HP:0012253)	2.09232517
55	Abnormal respiratory motile cilium morphology (HP:0005938)	2.09232517
56	Disproportionate short-trunk short stature (HP:0003521)	2.07882064
57	Rhinitis (HP:0012384)	2.07552881
58	Absent speech (HP:0001344)	2.04060038
59	Genital tract atresia (HP:0001827)	2.03568373
60	Febrile seizures (HP:0002373)	2.01043154
61	Tubular atrophy (HP:0000092)	2.00766772
62	Hypoplastic iliac wings (HP:0002866)	2.00532862
63	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.00088362
64	Metaphyseal dysplasia (HP:0100255)	1.99173938
65	Narrow forehead (HP:0000341)	1.98785894
66	Elevated erythrocyte sedimentation rate (HP:0003565)	1.98767682
67	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.98561799
68	Mitochondrial inheritance (HP:0001427)	1.95657418
69	Postaxial hand polydactyly (HP:0001162)	1.95453098
70	Hypothermia (HP:0002045)	1.92750401
71	Vaginal atresia (HP:0000148)	1.91720775
72	Asplenia (HP:0001746)	1.90582475
73	Albinism (HP:0001022)	1.89558225
74	Cerebellar dysplasia (HP:0007033)	1.88715178
75	Increased CSF lactate (HP:0002490)	1.88702009
76	Abnormal ciliary motility (HP:0012262)	1.88421694
77	Retinitis pigmentosa (HP:0000510)	1.88405814
78	Aganglionic megacolon (HP:0002251)	1.86939610
79	Rib fusion (HP:0000902)	1.85930817
80	Colon cancer (HP:0003003)	1.83385699
81	Lissencephaly (HP:0001339)	1.82706263
82	Renal cortical cysts (HP:0000803)	1.80818468
83	Furrowed tongue (HP:0000221)	1.80561873
84	Poor coordination (HP:0002370)	1.80555300
85	Supernumerary spleens (HP:0009799)	1.80343212
86	Chronic bronchitis (HP:0004469)	1.80071863
87	Polyuria (HP:0000103)	1.79370285
88	Intestinal atresia (HP:0011100)	1.77945611
89	Constricted visual fields (HP:0001133)	1.77901874
90	Protruding tongue (HP:0010808)	1.77567958
91	Genetic anticipation (HP:0003743)	1.76190417
92	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.73765564
93	Thyroid-stimulating hormone excess (HP:0002925)	1.73215216
94	Acute necrotizing encephalopathy (HP:0006965)	1.73100851
95	Progressive inability to walk (HP:0002505)	1.72633302
96	Dialeptic seizures (HP:0011146)	1.72144177
97	Hip dysplasia (HP:0001385)	1.71461504
98	Focal seizures (HP:0007359)	1.70590382
99	Tubulointerstitial abnormality (HP:0001969)	1.69795836
100	Pancreatic islet-cell hyperplasia (HP:0004510)	1.68849186

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.41057315
2	ADRBK2	2.81914422
3	NUAK1	2.79651396
4	BMPR1B	2.71725943
5	BCKDK	2.60357816
6	WNK3	2.59680499
7	MAP4K2	2.42820214
8	OXSR1	2.08156752
9	PINK1	1.95992696
10	WNK4	1.94254925
11	GRK1	1.93699224
12	ZAK	1.88254440
13	TAOK3	1.87398995
14	TXK	1.74685677
15	BCR	1.72663607
16	STK39	1.71630691
17	TLK1	1.68882123
18	CASK	1.59575166
19	MUSK	1.57989641
20	CCNB1	1.37009187
21	TNK2	1.28761302
22	MAP2K6	1.22764473
23	MAPK13	1.22275775
24	ACVR1B	1.18094771
25	PLK2	1.17853624
26	CDK19	1.09301324
27	INSRR	1.08552108
28	MST4	1.06254849
29	MAP3K4	1.06019737
30	EPHB2	1.04784679
31	IRAK1	1.01974860
32	TNIK	1.01561600
33	TEC	0.99440354
34	PIK3CG	0.98740991
35	PTK2B	0.95530615
36	EIF2AK1	0.95199068
37	PAK3	0.94508433
38	PRKCE	0.94209497
39	FLT3	0.89697450
40	STK11	0.87930566
41	AKT3	0.87721238
42	MAP2K7	0.85289680
43	CSNK1G1	0.82604872
44	ADRBK1	0.82512656
45	EPHA4	0.82383392
46	PRKCQ	0.82047690
47	STK3	0.80620962
48	STK38L	0.79208185
49	ITK	0.77313788
50	TGFBR1	0.77051549
51	NLK	0.75734329
52	TIE1	0.75541933
53	DYRK2	0.75402270
54	PRKCG	0.74080958
55	VRK1	0.73262325
56	KIT	0.72818791
57	MARK3	0.71051156
58	CSNK1G2	0.70304490
59	MKNK2	0.68211586
60	CSNK1G3	0.67390802
61	MAP3K7	0.65475969
62	MAPK7	0.64530252
63	PRKCI	0.64467288
64	FER	0.63692679
65	TRIM28	0.62134907
66	CAMK2A	0.61837569
67	PIM2	0.61386750
68	ERBB3	0.60454932
69	VRK2	0.60258430
70	MARK1	0.60225130
71	CAMK2D	0.57204487
72	FGFR2	0.56921703
73	OBSCN	0.56638466
74	MAPKAPK5	0.56476288
75	TAF1	0.55995093
76	MKNK1	0.51739606
77	EPHA3	0.51693813
78	NTRK2	0.51588680
79	PIK3CA	0.50542421
80	PNCK	0.50319235
81	PRKACA	0.50256984
82	IKBKB	0.49535120
83	CAMK1	0.48669319
84	ROCK1	0.48647505
85	CSNK1A1L	0.48392914
86	DAPK2	0.48171106
87	CSNK1D	0.45049512
88	TGFBR2	0.42032913
89	PKN1	0.41412743
90	BRSK2	0.40597494
91	CSF1R	0.39713052
92	CSNK1A1	0.38447766
93	PHKG2	0.38396657
94	PHKG1	0.38396657
95	EIF2AK3	0.37979131
96	PRKG1	0.37916962
97	GRK5	0.37575786
98	RPS6KA6	0.35539205
99	LATS1	0.34857377
100	CHEK2	0.34173893

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.75939633
2	Tryptophan metabolism_Homo sapiens_hsa00380	2.63048996
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.62510428
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.47426058
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.42275869
6	Butanoate metabolism_Homo sapiens_hsa00650	2.26293464
7	One carbon pool by folate_Homo sapiens_hsa00670	2.26080597
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.16222224
9	Protein export_Homo sapiens_hsa03060	2.16007987
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.12199263
11	Ether lipid metabolism_Homo sapiens_hsa00565	2.02800192
12	Phototransduction_Homo sapiens_hsa04744	1.99214462
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.91250941
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.85726224
15	Caffeine metabolism_Homo sapiens_hsa00232	1.84481812
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.81394480
17	Basal transcription factors_Homo sapiens_hsa03022	1.81374084
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.70081139
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.69645469
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.69633421
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.65851114
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.65152296
23	RNA degradation_Homo sapiens_hsa03018	1.62819988
24	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.61461706
25	Propanoate metabolism_Homo sapiens_hsa00640	1.60776422
26	Chemical carcinogenesis_Homo sapiens_hsa05204	1.59951159
27	Olfactory transduction_Homo sapiens_hsa04740	1.41635054
28	Nicotine addiction_Homo sapiens_hsa05033	1.37081385
29	Asthma_Homo sapiens_hsa05310	1.36033321
30	Homologous recombination_Homo sapiens_hsa03440	1.32047100
31	beta-Alanine metabolism_Homo sapiens_hsa00410	1.30938346
32	Peroxisome_Homo sapiens_hsa04146	1.29784036
33	Allograft rejection_Homo sapiens_hsa05330	1.23548044
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.19928168
35	Retinol metabolism_Homo sapiens_hsa00830	1.19006815
36	Graft-versus-host disease_Homo sapiens_hsa05332	1.16792242
37	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.15955500
38	Type I diabetes mellitus_Homo sapiens_hsa04940	1.14548589
39	Mineral absorption_Homo sapiens_hsa04978	1.14147084
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.09904737
41	Oxidative phosphorylation_Homo sapiens_hsa00190	1.08414095
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.08133570
43	Non-homologous end-joining_Homo sapiens_hsa03450	1.06283731
44	RNA polymerase_Homo sapiens_hsa03020	1.05426549
45	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.04437219
46	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.03912838
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01833052
48	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01420258
49	Fatty acid degradation_Homo sapiens_hsa00071	0.98365026
50	Taste transduction_Homo sapiens_hsa04742	0.95058884
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.95017762
52	Regulation of autophagy_Homo sapiens_hsa04140	0.93007717
53	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.90226862
54	Ribosome_Homo sapiens_hsa03010	0.89897751
55	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.89004273
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.88930735
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.86773112
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.85403959
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83037653
60	Selenocompound metabolism_Homo sapiens_hsa00450	0.82071275
61	Insulin secretion_Homo sapiens_hsa04911	0.81558826
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81004144
63	ABC transporters_Homo sapiens_hsa02010	0.79391938
64	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.78536150
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77465496
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.77202802
67	Histidine metabolism_Homo sapiens_hsa00340	0.75657544
68	Parkinsons disease_Homo sapiens_hsa05012	0.73581499
69	Fatty acid elongation_Homo sapiens_hsa00062	0.72979220
70	Cardiac muscle contraction_Homo sapiens_hsa04260	0.71004744
71	Salivary secretion_Homo sapiens_hsa04970	0.69906713
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.69621579
73	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.68664446
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.67519728
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.65553625
76	Metabolic pathways_Homo sapiens_hsa01100	0.64923363
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.64054986
78	Huntingtons disease_Homo sapiens_hsa05016	0.63063944
79	Serotonergic synapse_Homo sapiens_hsa04726	0.57780089
80	Rheumatoid arthritis_Homo sapiens_hsa05323	0.57619837
81	Glutamatergic synapse_Homo sapiens_hsa04724	0.57059751
82	Tyrosine metabolism_Homo sapiens_hsa00350	0.56307103
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54886241
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.54815846
85	Morphine addiction_Homo sapiens_hsa05032	0.50994667
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.47100949
87	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.46954646
88	Circadian entrainment_Homo sapiens_hsa04713	0.45876082
89	Proteasome_Homo sapiens_hsa03050	0.44881948
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.44869732
91	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44734256
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.43655874
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.42561533
94	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41605445
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40278699
96	Purine metabolism_Homo sapiens_hsa00230	0.37950831
97	African trypanosomiasis_Homo sapiens_hsa05143	0.37698246
98	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.36252089
99	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.35094948
100	Long-term depression_Homo sapiens_hsa04730	0.34556644

MGAT4EP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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