MGAT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)7.82319752
2glomerular epithelial cell development (GO:0072310)7.18202106
3glomerular basement membrane development (GO:0032836)5.17935578
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.44058747
5hypotonic response (GO:0006971)4.22773099
6synaptic vesicle maturation (GO:0016188)4.03380750
7locomotory exploration behavior (GO:0035641)4.01411049
8glomerulus development (GO:0032835)3.80539242
9cellular potassium ion homeostasis (GO:0030007)3.77595772
10epithelial cell differentiation involved in kidney development (GO:0035850)3.67189196
11melanin biosynthetic process (GO:0042438)3.62317732
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.57097122
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.56990866
14layer formation in cerebral cortex (GO:0021819)3.51885710
15sodium ion export (GO:0071436)3.48210672
16melanin metabolic process (GO:0006582)3.47642845
17synaptic vesicle exocytosis (GO:0016079)3.45008535
18nerve growth factor signaling pathway (GO:0038180)3.42984213
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.42753514
20glutamate secretion (GO:0014047)3.42082380
21skin morphogenesis (GO:0043589)3.37887925
22vocalization behavior (GO:0071625)3.36723011
23regulation of synaptic vesicle exocytosis (GO:2000300)3.34705074
24regulation of early endosome to late endosome transport (GO:2000641)3.26396621
25adherens junction assembly (GO:0034333)3.23350917
26regulation of NFAT protein import into nucleus (GO:0051532)3.19673332
27stress fiber assembly (GO:0043149)3.16913858
28proline transport (GO:0015824)3.12768201
29regulation of glutamate receptor signaling pathway (GO:1900449)3.11925704
30cell-substrate junction assembly (GO:0007044)3.07394635
31cell adhesion mediated by integrin (GO:0033627)3.07321822
32focal adhesion assembly (GO:0048041)3.05613324
33cell-substrate adherens junction assembly (GO:0007045)3.05613324
34regulation of ARF protein signal transduction (GO:0032012)3.04529786
35L-amino acid import (GO:0043092)3.03093135
36neuron cell-cell adhesion (GO:0007158)3.01933445
37positive regulation of receptor recycling (GO:0001921)3.00823883
38protein localization to synapse (GO:0035418)3.00136096
39ionotropic glutamate receptor signaling pathway (GO:0035235)2.99722803
40synaptic vesicle docking involved in exocytosis (GO:0016081)2.98114156
41dendrite morphogenesis (GO:0048813)2.94463602
42basement membrane organization (GO:0071711)2.92398501
43synaptic vesicle endocytosis (GO:0048488)2.91314693
44dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.90699039
45cytoskeletal anchoring at plasma membrane (GO:0007016)2.89969649
46clathrin coat assembly (GO:0048268)2.88813854
47regulation of axon guidance (GO:1902667)2.87097509
48regulation of synapse structural plasticity (GO:0051823)2.86695274
49cerebellar Purkinje cell differentiation (GO:0021702)2.86650002
50exploration behavior (GO:0035640)2.84746602
51apoptotic cell clearance (GO:0043277)2.83706559
52regulation of synaptic vesicle transport (GO:1902803)2.83198686
53Golgi transport vesicle coating (GO:0048200)2.79754327
54COPI coating of Golgi vesicle (GO:0048205)2.79754327
55epithelial cell-cell adhesion (GO:0090136)2.79584030
56secondary metabolite biosynthetic process (GO:0044550)2.76170678
57barbed-end actin filament capping (GO:0051016)2.74104745
58response to laminar fluid shear stress (GO:0034616)2.73628159
59pinocytosis (GO:0006907)2.73352810
60protein localization to endosome (GO:0036010)2.72046897
61dendritic spine morphogenesis (GO:0060997)2.69604285
62neuron recognition (GO:0008038)2.69575640
63mating behavior (GO:0007617)2.69567459
64regulation of long-term neuronal synaptic plasticity (GO:0048169)2.68809640
65glutamate receptor signaling pathway (GO:0007215)2.67976324
66axonal fasciculation (GO:0007413)2.67144120
67planar cell polarity pathway involved in neural tube closure (GO:0090179)2.65603953
68neurotransmitter secretion (GO:0007269)2.65497764
69embryonic process involved in female pregnancy (GO:0060136)2.64618778
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.63642995
71long-term memory (GO:0007616)2.63156820
72neuromuscular process controlling balance (GO:0050885)2.61565852
73angiotensin maturation (GO:0002003)2.60961140
74cortical actin cytoskeleton organization (GO:0030866)2.60842198
75synaptic transmission, glutamatergic (GO:0035249)2.59980201
76endodermal cell differentiation (GO:0035987)2.59844334
77regulation of neuronal synaptic plasticity (GO:0048168)2.58154433
78vesicle transport along microtubule (GO:0047496)2.58071826
79regulation of excitatory postsynaptic membrane potential (GO:0060079)2.55153053
80establishment of nucleus localization (GO:0040023)2.54564521
81potassium ion import (GO:0010107)2.53085865
82gamma-aminobutyric acid signaling pathway (GO:0007214)2.51813832
83negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50222147
84negative regulation of cell killing (GO:0031342)2.50222147
85retrograde transport, vesicle recycling within Golgi (GO:0000301)2.49982141
86activation of protein kinase A activity (GO:0034199)2.49828786
87cerebellar granule cell differentiation (GO:0021707)2.49063446
88regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.48709037
89presynaptic membrane assembly (GO:0097105)2.48616500
90substrate-dependent cell migration (GO:0006929)2.47850454
91regulation of extracellular matrix disassembly (GO:0010715)2.47659046
92protein retention in ER lumen (GO:0006621)2.46770956
93adhesion of symbiont to host (GO:0044406)2.46365590
94neuronal action potential propagation (GO:0019227)2.45994222
95regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45681984
96regulation of postsynaptic membrane potential (GO:0060078)2.44914370
97G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.44581054
98suckling behavior (GO:0001967)2.44574504
99endocytic recycling (GO:0032456)2.43355876
100maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.42474153
101gamma-aminobutyric acid transport (GO:0015812)2.42260362
102neuron-neuron synaptic transmission (GO:0007270)2.40270184
103insulin-like growth factor receptor signaling pathway (GO:0048009)2.39577895
104negative regulation of fatty acid transport (GO:2000192)2.39113209
105regulation of axon extension involved in axon guidance (GO:0048841)2.39045832
106neurotransmitter-gated ion channel clustering (GO:0072578)2.38391485
107potassium ion homeostasis (GO:0055075)2.38099598
108negative regulation of vascular permeability (GO:0043116)2.37857192
109cortical cytoskeleton organization (GO:0030865)2.37818106
110regulation of Rac protein signal transduction (GO:0035020)2.37465146
111activation of MAPKKK activity (GO:0000185)2.36754706
112regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.36221327
113membrane hyperpolarization (GO:0060081)2.35861329
114long-term synaptic potentiation (GO:0060291)2.35469555
115regulation of ARF GTPase activity (GO:0032312)2.35372676
116regulation of glucose import in response to insulin stimulus (GO:2001273)2.34548597
117phospholipid translocation (GO:0045332)2.33710391
118lipid translocation (GO:0034204)2.33710391
119cellular response to nerve growth factor stimulus (GO:1990090)2.33449343
120response to nerve growth factor (GO:1990089)2.33449343
121hemidesmosome assembly (GO:0031581)2.33177280
122diaphragm development (GO:0060539)2.30907520
123Golgi to endosome transport (GO:0006895)2.29814834
124transmission of nerve impulse (GO:0019226)2.29729912
125regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.28958938
126membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.28687580
127platelet-derived growth factor receptor signaling pathway (GO:0048008)2.28575359
128response to histamine (GO:0034776)2.28480169
129positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.28327384
130positive regulation of extracellular matrix organization (GO:1903055)2.28192285
131endocardial cushion development (GO:0003197)2.28015327
132semaphorin-plexin signaling pathway (GO:0071526)2.27606233
133regulation of neurotransmitter secretion (GO:0046928)2.27094863
134protein targeting to Golgi (GO:0000042)2.27057160
135actin cytoskeleton reorganization (GO:0031532)2.26569579
136positive regulation of Rap GTPase activity (GO:0032854)2.25919961
137mannose metabolic process (GO:0006013)2.25870040
138retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.25852582
139regulation of synaptic plasticity (GO:0048167)2.25841048
140negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.25798050
141peptidyl-threonine modification (GO:0018210)2.25484034
142cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.24839153
143virion attachment to host cell (GO:0019062)2.24478833
144adhesion of symbiont to host cell (GO:0044650)2.24478833
145response to auditory stimulus (GO:0010996)2.24404788
146regulation of Rap GTPase activity (GO:0032317)2.24154231
147positive regulation of membrane potential (GO:0045838)2.23366988
148positive regulation of p38MAPK cascade (GO:1900745)2.23353374
149regulation of beta-amyloid formation (GO:1902003)2.22892569
150negative regulation of anoikis (GO:2000811)2.22582057
151establishment of protein localization to Golgi (GO:0072600)2.22471521
152cellular response to prostaglandin stimulus (GO:0071379)2.21074669
153peptidyl-threonine phosphorylation (GO:0018107)2.20583694
154cellular protein complex localization (GO:0034629)2.20496876
155negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.19877541
156regulation of cholesterol homeostasis (GO:2000188)2.19483256
157histone H3-K36 demethylation (GO:0070544)2.17087882
158positive regulation of blood vessel endothelial cell migration (GO:0043536)2.14836312
159mesodermal cell differentiation (GO:0048333)2.12996805
160positive regulation of cell size (GO:0045793)2.11695077
161negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.11514128
162receptor catabolic process (GO:0032801)2.11388897
163vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.10910907
164modulation by symbiont of host cellular process (GO:0044068)2.09067036
165positive regulation of endothelial cell apoptotic process (GO:2000353)2.08750061
166chondrocyte proliferation (GO:0035988)2.08452889
167activation of Rac GTPase activity (GO:0032863)2.08410498
168activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.07300191
169protein targeting to plasma membrane (GO:0072661)2.06520490
170actin filament bundle assembly (GO:0051017)2.06479948
171actin filament bundle organization (GO:0061572)2.06479948
172embryonic camera-type eye morphogenesis (GO:0048596)2.06308977
173positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.05572286
174branching involved in mammary gland duct morphogenesis (GO:0060444)2.05297343
175receptor recycling (GO:0001881)2.00281521
176negative regulation of protein localization to plasma membrane (GO:1903077)2.00169279
177skeletal muscle organ development (GO:0060538)2.00062053
178positive regulation of axon extension (GO:0045773)1.98868958
179activation of JUN kinase activity (GO:0007257)1.97660359
180membrane protein ectodomain proteolysis (GO:0006509)1.97363191
181venous blood vessel morphogenesis (GO:0048845)1.96904192
182negative regulation of erythrocyte differentiation (GO:0045647)1.96569295
183positive regulation of nuclease activity (GO:0032075)1.96261574
184peptide catabolic process (GO:0043171)1.95903503
185regulation of extracellular matrix organization (GO:1903053)1.95439104
186cellular copper ion homeostasis (GO:0006878)1.95320579
187response to fluid shear stress (GO:0034405)1.95113149
188cell-cell junction maintenance (GO:0045217)1.94790350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.96563518
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.99287329
3GBX2_23144817_ChIP-Seq_PC3_Human2.67668629
4DROSHA_22980978_ChIP-Seq_HELA_Human2.40292409
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29867857
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.26194428
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24303852
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15416847
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.09399781
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08019758
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.08006916
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06041946
13CLOCK_20551151_ChIP-Seq_293T_Human2.05384134
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98978553
15CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97024114
16ELK3_25401928_ChIP-Seq_HUVEC_Human1.95449476
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93952957
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93339238
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93331143
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93331143
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.93124425
22TCF7_22412390_ChIP-Seq_EML_Mouse1.89385950
23MYC_22102868_ChIP-Seq_BL_Human1.86203977
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.83913308
25* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83112597
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78543379
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78307913
28LXR_22292898_ChIP-Seq_THP-1_Human1.76663524
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75245493
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73776697
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.73515138
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72863023
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70918835
34REST_21632747_ChIP-Seq_MESCs_Mouse1.70535091
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69294802
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66913820
37AR_21572438_ChIP-Seq_LNCaP_Human1.65225719
38SOX9_24532713_ChIP-Seq_HFSC_Mouse1.64514440
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64449747
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.63241558
41* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.62161104
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.61068944
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59723682
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58139725
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57465176
46NFIB_24661679_ChIP-Seq_LUNG_Mouse1.56929832
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56857243
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.55746438
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.54647733
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54363053
51* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53395426
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.52510876
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48232271
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47204956
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47188500
56TP53_16413492_ChIP-PET_HCT116_Human1.45558706
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.45386724
58* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45069564
59* SMAD4_21799915_ChIP-Seq_A2780_Human1.44787825
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44634526
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.42570664
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41882648
63* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40537533
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40315857
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40062615
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40049063
67TBX20_22080862_ChIP-Seq_HEART_Mouse1.39574828
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.39574828
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.39428988
70* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39414462
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37880843
72* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37609574
73RACK7_27058665_Chip-Seq_MCF-7_Human1.37277728
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36458757
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35732276
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35459143
77* FOXA2_19822575_ChIP-Seq_HepG2_Human1.34985420
78VDR_21846776_ChIP-Seq_THP-1_Human1.33489664
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.33149986
80AHR_22903824_ChIP-Seq_MCF-7_Human1.32941603
81* FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32448673
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.32335719
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32032319
84* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31825778
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31152643
86* EP300_21415370_ChIP-Seq_HL-1_Mouse1.29896937
87* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27117039
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27082513
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.26844239
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26733526
91STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26099998
92REST_18959480_ChIP-ChIP_MESCs_Mouse1.24597985
93* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23272988
94SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22813298
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22595991
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22369443
97* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22268260
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20968998
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20662068
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20539289
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20349259
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20264311
103* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19575830
104* KDM2B_26808549_Chip-Seq_K562_Human1.19388240
105* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18882993
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.18792779
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18644893
108RXR_22108803_ChIP-Seq_LS180_Human1.18069324
109* STAT3_23295773_ChIP-Seq_U87_Human1.17941767
110* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17452114
111RUNX_20019798_ChIP-Seq_JUKART_Human1.16666287
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16632320
113* GATA1_19941827_ChIP-Seq_MEL_Mouse1.16481880
114KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15429928
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15166382
116TAF15_26573619_Chip-Seq_HEK293_Human1.14921946
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14283597
118* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14269114
119VDR_24787735_ChIP-Seq_THP-1_Human1.13778839
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12336457
121NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12163111
122TCF4_23295773_ChIP-Seq_U87_Human1.11968688
123TP53_22127205_ChIP-Seq_IMR90_Human1.11767145
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11188069
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.10667517
126GATA1_19941826_ChIP-Seq_K562_Human1.09509115
127ERG_21242973_ChIP-ChIP_JURKAT_Human1.08945720
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08667635
129BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08314696
130P300_19829295_ChIP-Seq_ESCs_Human1.08141647
131* AR_25329375_ChIP-Seq_VCAP_Human1.06963093
132AR_19668381_ChIP-Seq_PC3_Human1.06718032
133UBF1/2_26484160_Chip-Seq_HMECs_Human1.05616374
134PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04365675
135IRF8_27001747_Chip-Seq_BMDM_Mouse1.03259513
136VDR_24763502_ChIP-Seq_THP-1_Human1.02975497
137SMAD3_21741376_ChIP-Seq_ESCs_Human1.02672563
138RUNX1_27514584_Chip-Seq_MCF-7_Human1.02244713
139SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02158279
140SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02158279
141* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01974283
142ZNF274_21170338_ChIP-Seq_K562_Hela1.01960515
143SPI1_23127762_ChIP-Seq_K562_Human1.01956408
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01515774
145RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01500123
146TCF4_18268006_ChIP-ChIP_LS174T_Human1.01351385
147TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00358386
148DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00259611
149ESR1_21235772_ChIP-Seq_MCF-7_Human0.98521660
150PRDM14_20953172_ChIP-Seq_ESCs_Human0.97992784
151ZNF263_19887448_ChIP-Seq_K562_Human0.97551135
152* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97314591
153GATA2_21666600_ChIP-Seq_HMVEC_Human0.96952853
154EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95944692
155SMAD3_21741376_ChIP-Seq_HESCs_Human0.95837261
156CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95730925
157SMC4_20622854_ChIP-Seq_HELA_Human0.95326603
158* TP53_23651856_ChIP-Seq_MEFs_Mouse0.95249014
159* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95173798
160RING1B_27294783_Chip-Seq_ESCs_Mouse0.94616846
161* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94543883
162ER_23166858_ChIP-Seq_MCF-7_Human0.94061577
163P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93395331
164RING1B_27294783_Chip-Seq_NPCs_Mouse0.93144562
165MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92419863
166NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91523050
167* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90645893
168KDM2B_26808549_Chip-Seq_DND41_Human0.90247111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.34900258
2MP0003705_abnormal_hypodermis_morpholog4.12143903
3MP0008438_abnormal_cutaneous_collagen4.06544541
4MP0000569_abnormal_digit_pigmentation3.48452502
5MP0010368_abnormal_lymphatic_system3.38649973
6MP0003566_abnormal_cell_adhesion3.32502126
7MP0003635_abnormal_synaptic_transmissio3.13360422
8MP0005257_abnormal_intraocular_pressure2.83884907
9MP0003880_abnormal_central_pattern2.80450440
10MP0009046_muscle_twitch2.55526735
11MP0002064_seizures2.55239591
12MP0004272_abnormal_basement_membrane2.55055356
13MP0002063_abnormal_learning/memory/cond2.54565406
14MP0009745_abnormal_behavioral_response2.49353403
15MP0004270_analgesia2.44451400
16MP0005076_abnormal_cell_differentiation2.42227650
17MP0005171_absent_coat_pigmentation2.39272894
18MP0003279_aneurysm2.32134706
19MP0000372_irregular_coat_pigmentation2.31577163
20MP0001486_abnormal_startle_reflex2.20197092
21MP0009780_abnormal_chondrocyte_physiolo2.18626427
22MP0003172_abnormal_lysosome_physiology2.18105337
23MP0000015_abnormal_ear_pigmentation2.15697715
24MP0005623_abnormal_meninges_morphology2.14122267
25MP0002572_abnormal_emotion/affect_behav2.13287323
26MP0003690_abnormal_glial_cell1.99619308
27MP0003300_gastrointestinal_ulcer1.97827576
28MP0010352_gastrointestinal_tract_polyps1.94619784
29MP0005409_darkened_coat_color1.93858397
30MP0005423_abnormal_somatic_nervous1.93559938
31MP0005174_abnormal_tail_pigmentation1.91779446
32MP0004885_abnormal_endolymph1.90987599
33MP0000767_abnormal_smooth_muscle1.90600125
34MP0001958_emphysema1.90565924
35MP0003183_abnormal_peptide_metabolism1.88623409
36MP0003329_amyloid_beta_deposits1.88081787
37MP0003303_peritoneal_inflammation1.84323909
38MP0001849_ear_inflammation1.80337969
39MP0004233_abnormal_muscle_weight1.75025072
40MP0000920_abnormal_myelination1.72953819
41MP0002734_abnormal_mechanical_nocicepti1.71223111
42MP0001968_abnormal_touch/_nociception1.70727143
43MP0003787_abnormal_imprinting1.67902677
44MP0002090_abnormal_vision1.66439141
45MP0002272_abnormal_nervous_system1.65856067
46MP0001440_abnormal_grooming_behavior1.65228358
47MP0005451_abnormal_body_composition1.62831214
48MP0001915_intracranial_hemorrhage1.61065678
49MP0009840_abnormal_foam_cell1.60894711
50MP0008569_lethality_at_weaning1.59316648
51MP0004811_abnormal_neuron_physiology1.49174132
52MP0008260_abnormal_autophagy1.48538555
53MP0002896_abnormal_bone_mineralization1.48127388
54MP0002067_abnormal_sensory_capabilities1.47408906
55MP0005275_abnormal_skin_tensile1.45379290
56MP0000604_amyloidosis1.43755691
57MP0000733_abnormal_muscle_development1.42186894
58MP0000778_abnormal_nervous_system1.41604568
59MP0005023_abnormal_wound_healing1.39201036
60MP0008961_abnormal_basal_metabolism1.38823246
61MP0006054_spinal_hemorrhage1.38243535
62MP0004084_abnormal_cardiac_muscle1.35901538
63MP0001879_abnormal_lymphatic_vessel1.35769469
64MP0003634_abnormal_glial_cell1.33204251
65MP0003453_abnormal_keratinocyte_physiol1.32998435
66MP0004858_abnormal_nervous_system1.32911090
67MP0002733_abnormal_thermal_nociception1.31493669
68MP0001501_abnormal_sleep_pattern1.30183200
69MP0003633_abnormal_nervous_system1.29826177
70MP0006138_congestive_heart_failure1.28755187
71MP0001970_abnormal_pain_threshold1.26513391
72MP0000534_abnormal_ureter_morphology1.25899401
73MP0005386_behavior/neurological_phenoty1.24201672
74MP0004924_abnormal_behavior1.24201672
75MP0000566_synostosis1.21871311
76MP0001324_abnormal_eye_pigmentation1.21371941
77MP0001348_abnormal_lacrimal_gland1.21331334
78MP0000371_diluted_coat_color1.21290229
79MP0005167_abnormal_blood-brain_barrier1.19731039
80MP0003075_altered_response_to1.19723818
81MP0002735_abnormal_chemical_nociception1.18418548
82MP0002095_abnormal_skin_pigmentation1.17548955
83MP0000955_abnormal_spinal_cord1.17325875
84* MP0002557_abnormal_social/conspecific_i1.17114392
85MP0009384_cardiac_valve_regurgitation1.15592036
86MP0003191_abnormal_cellular_cholesterol1.14927065
87MP0009053_abnormal_anal_canal1.14640602
88MP0003436_decreased_susceptibility_to1.14261980
89MP0003828_pulmonary_edema1.12814458
90MP0002882_abnormal_neuron_morphology1.12286355
91MP0005058_abnormal_lysosome_morphology1.11365843
92MP0002184_abnormal_innervation1.10809440
93MP0002877_abnormal_melanocyte_morpholog1.09474039
94MP0002229_neurodegeneration1.09301636
95MP0002736_abnormal_nociception_after1.08317141
96MP0002009_preneoplasia1.07491041
97MP0003045_fibrosis1.07281330
98MP0004947_skin_inflammation1.06608169
99MP0003631_nervous_system_phenotype1.05140261
100MP0001502_abnormal_circadian_rhythm1.05019377
101MP0002066_abnormal_motor_capabilities/c1.03285139
102MP0005645_abnormal_hypothalamus_physiol1.02759239
103* MP0000858_altered_metastatic_potential1.02283492
104MP0002909_abnormal_adrenal_gland1.00286870
105MP0004742_abnormal_vestibular_system1.00026278
106MP0003632_abnormal_nervous_system0.98498523
107MP0005503_abnormal_tendon_morphology0.98399685
108MP0005621_abnormal_cell_physiology0.98381043
109MP0005551_abnormal_eye_electrophysiolog0.98347020
110MP0001963_abnormal_hearing_physiology0.94048471
111MP0008004_abnormal_stomach_pH0.93963359
112MP0002060_abnormal_skin_morphology0.93239428
113MP0002152_abnormal_brain_morphology0.92110342
114MP0000465_gastrointestinal_hemorrhage0.91398226
115* MP0003448_altered_tumor_morphology0.88784245
116MP0010234_abnormal_vibrissa_follicle0.88553739
117MP0010630_abnormal_cardiac_muscle0.88365376
118MP0000428_abnormal_craniofacial_morphol0.88143171
119MP0001984_abnormal_olfaction0.87856516
120MP0003879_abnormal_hair_cell0.87162965
121MP0000751_myopathy0.86487446
122MP0001533_abnormal_skeleton_physiology0.82318658
123MP0001614_abnormal_blood_vessel0.80851956
124MP0004036_abnormal_muscle_relaxation0.80784598
125MP0010386_abnormal_urinary_bladder0.80620939
126MP0002128_abnormal_blood_circulation0.80491462
127MP0004264_abnormal_extraembryonic_tissu0.79804789
128MP0003091_abnormal_cell_migration0.78997229
129MP0005508_abnormal_skeleton_morphology0.78937175
130MP0005408_hypopigmentation0.78784009
131MP0009278_abnormal_bone_marrow0.78394155
132MP0003866_abnormal_defecation0.78125733
133MP0002925_abnormal_cardiovascular_devel0.77526514
134MP0010678_abnormal_skin_adnexa0.76845839
135MP0000432_abnormal_head_morphology0.76661632
136MP0005646_abnormal_pituitary_gland0.76625803
137MP0006082_CNS_inflammation0.75796387
138MP0005164_abnormal_response_to0.75270915
139MP0002086_abnormal_extraembryonic_tissu0.73989168
140MP0003941_abnormal_skin_development0.71170922
141MP0003115_abnormal_respiratory_system0.70979130
142MP0004883_abnormal_blood_vessel0.69959591
143MP0003868_abnormal_feces_composition0.69685367
144MP0005310_abnormal_salivary_gland0.69535309
145MP0001485_abnormal_pinna_reflex0.68782671
146MP0002113_abnormal_skeleton_development0.68478480
147MP0000537_abnormal_urethra_morphology0.68126699
148MP0003942_abnormal_urinary_system0.67574103
149MP0000013_abnormal_adipose_tissue0.66848771
150MP0005390_skeleton_phenotype0.66555483
151MP0000490_abnormal_crypts_of0.66372748
152MP0005166_decreased_susceptibility_to0.65972992
153MP0002089_abnormal_postnatal_growth/wei0.65737885
154MP0001299_abnormal_eye_distance/0.63828595
155MP0002998_abnormal_bone_remodeling0.63706991
156MP0010155_abnormal_intestine_physiology0.62877464
157MP0008874_decreased_physiological_sensi0.62557783
158MP0004510_myositis0.61783623
159MP0002075_abnormal_coat/hair_pigmentati0.61696120
160MP0004484_altered_response_of0.61575801
161MP0002166_altered_tumor_susceptibility0.61415832
162MP0005165_increased_susceptibility_to0.61180194
163MP0005464_abnormal_platelet_physiology0.61027917
164MP0003763_abnormal_thymus_physiology0.60246040
165MP0000249_abnormal_blood_vessel0.59236157
166MP0001851_eye_inflammation0.58695543
167MP0001905_abnormal_dopamine_level0.57536256
168MP0005197_abnormal_uvea_morphology0.57299200
169MP0002168_other_aberrant_phenotype0.57196427
170MP0000477_abnormal_intestine_morphology0.56227178
171MP0001943_abnormal_respiration0.54529234

Predicted human phenotypes

RankGene SetZ-score
1Mesangial abnormality (HP:0001966)4.31532624
2Focal segmental glomerulosclerosis (HP:0000097)4.20206754
3Protrusio acetabuli (HP:0003179)4.00179182
4Papilledema (HP:0001085)3.60466900
5Premature rupture of membranes (HP:0001788)3.59894097
6Focal motor seizures (HP:0011153)3.51274870
7Vascular tortuosity (HP:0004948)3.41302838
8Focal seizures (HP:0007359)3.27846545
9Abnormal albumin level (HP:0012116)3.19511167
10Hypoalbuminemia (HP:0003073)3.19511167
11Visual hallucinations (HP:0002367)3.16243811
12Myokymia (HP:0002411)3.09538435
13Supranuclear gaze palsy (HP:0000605)3.06077192
14Blue irides (HP:0000635)3.03428213
15Atonic seizures (HP:0010819)3.03356842
16Glomerulosclerosis (HP:0000096)2.95702093
17Ocular albinism (HP:0001107)2.94125433
18Cerebral aneurysm (HP:0004944)2.87409266
19Epileptic encephalopathy (HP:0200134)2.83777758
20Flat acetabular roof (HP:0003180)2.78352267
21Progressive cerebellar ataxia (HP:0002073)2.75644778
22Action tremor (HP:0002345)2.73433759
23Neonatal short-limb short stature (HP:0008921)2.72902293
24Iris hypopigmentation (HP:0007730)2.71489675
25Absence seizures (HP:0002121)2.70011915
26Aortic dissection (HP:0002647)2.65263229
27Rapidly progressive (HP:0003678)2.63186480
28Mutism (HP:0002300)2.57954160
29Aortic aneurysm (HP:0004942)2.54121177
30Truncal ataxia (HP:0002078)2.51962495
31Disproportionate tall stature (HP:0001519)2.49103071
32Inappropriate behavior (HP:0000719)2.48872969
33Hyperacusis (HP:0010780)2.43732667
34Macroorchidism (HP:0000053)2.42340121
35Neurofibrillary tangles (HP:0002185)2.42210288
36Increased cerebral lipofuscin (HP:0011813)2.41107692
37Abnormality of binocular vision (HP:0011514)2.41000744
38Diplopia (HP:0000651)2.41000744
39Febrile seizures (HP:0002373)2.38504056
40Intention tremor (HP:0002080)2.37026871
41Urinary glycosaminoglycan excretion (HP:0003541)2.35809146
42Mucopolysacchariduria (HP:0008155)2.35809146
43Atrophic scars (HP:0001075)2.35625960
44Gaze-evoked nystagmus (HP:0000640)2.35570134
45Obstructive sleep apnea (HP:0002870)2.34029769
46Wormian bones (HP:0002645)2.33364131
47Dialeptic seizures (HP:0011146)2.31408071
48Urinary bladder sphincter dysfunction (HP:0002839)2.27876003
49Bladder diverticulum (HP:0000015)2.27289478
50Stage 5 chronic kidney disease (HP:0003774)2.26701518
51Genetic anticipation (HP:0003743)2.22699808
52Aqueductal stenosis (HP:0002410)2.19992952
53Cerebral inclusion bodies (HP:0100314)2.19516697
54Shallow orbits (HP:0000586)2.19039924
55Abnormality of carpal bone ossification (HP:0006257)2.18245219
56Mitral valve prolapse (HP:0001634)2.17793769
57Aneurysm (HP:0002617)2.16865157
58Abnormal eating behavior (HP:0100738)2.16390806
59Dysmetria (HP:0001310)2.16362473
60Stereotypic behavior (HP:0000733)2.15398839
61Ankle contracture (HP:0006466)2.15023701
62Spastic gait (HP:0002064)2.13997572
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13497921
64Abnormality of polysaccharide metabolism (HP:0011012)2.13497921
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13497921
66Deep venous thrombosis (HP:0002625)2.13003768
67Apathy (HP:0000741)2.12303952
68Dilatation of the ascending aorta (HP:0005111)2.12095891
69Ankle clonus (HP:0011448)2.11325794
70Blue sclerae (HP:0000592)2.11222504
71Insomnia (HP:0100785)2.10418863
72Generalized hypopigmentation (HP:0007513)2.09599764
73Drooling (HP:0002307)2.09331987
74Excessive salivation (HP:0003781)2.09331987
75Vertebral compression fractures (HP:0002953)2.09280929
76Abnormal ossification of hand bones (HP:0005921)2.09153716
77Depression (HP:0000716)2.08832148
78Absent frontal sinuses (HP:0002688)2.08814985
79Elfin facies (HP:0004428)2.07940685
80Upper limb amyotrophy (HP:0009129)2.07888291
81Distal upper limb amyotrophy (HP:0007149)2.07888291
82Generalized tonic-clonic seizures (HP:0002069)2.06800946
83Abnormality of the corticospinal tract (HP:0002492)2.06654161
84Asymmetry of the thorax (HP:0001555)2.06552554
85Overriding aorta (HP:0002623)2.06381083
86Dysdiadochokinesis (HP:0002075)2.05019531
87Nephritis (HP:0000123)2.04822012
88Hypoproteinemia (HP:0003075)2.04287137
89Disinhibition (HP:0000734)2.03477863
90Poor eye contact (HP:0000817)2.02718828
91Thin bony cortex (HP:0002753)2.02105512
92Sensory axonal neuropathy (HP:0003390)2.01001020
93Urinary urgency (HP:0000012)2.00420031
94Nephrotic syndrome (HP:0000100)2.00179222
95Long palpebral fissure (HP:0000637)1.99528452
96Genu recurvatum (HP:0002816)1.99038454
97J-shaped sella turcica (HP:0002680)1.98046273
98Diminished motivation (HP:0000745)1.97734699
99Broad face (HP:0000283)1.97666187
100Hemiplegia (HP:0002301)1.96939243
101Generalized hypopigmentation of hair (HP:0011358)1.96733111
102Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.96500741
103Increased neuronal autofluorescent lipopigment (HP:0002074)1.95825052
104Mitral regurgitation (HP:0001653)1.94956124
105Abnormality of the fingertips (HP:0001211)1.94892626
106Neuronal loss in central nervous system (HP:0002529)1.94842229
107Fragile skin (HP:0001030)1.93837303
108Tubular atrophy (HP:0000092)1.93229373
109Impaired social interactions (HP:0000735)1.92727506
110Abnormal social behavior (HP:0012433)1.92727506
111Osteolytic defects of the hand bones (HP:0009699)1.91691676
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.91691676
113Dysmetric saccades (HP:0000641)1.91406157
114Vertebral arch anomaly (HP:0008438)1.91131516
115Ulnar bowing (HP:0003031)1.90830243
116Postural instability (HP:0002172)1.90773305
117Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.89970728
118Subacute progressive viral hepatitis (HP:0006572)1.89896579
119Megalencephaly (HP:0001355)1.89209349
120Open mouth (HP:0000194)1.88855458
121Glomerulonephritis (HP:0000099)1.88702826
122Cervical subluxation (HP:0003308)1.87526747
123Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87500285
124Broad-based gait (HP:0002136)1.87131808
125Pointed chin (HP:0000307)1.85695861
126Leiomyosarcoma (HP:0100243)1.85073686
127Uterine leiomyosarcoma (HP:0002891)1.85073686
128Spondylolisthesis (HP:0003302)1.84847277
129Natal tooth (HP:0000695)1.83750640
130Peritonitis (HP:0002586)1.83648315
131Cupped ribs (HP:0000887)1.83273012
132Spinal rigidity (HP:0003306)1.82996582
133Joint laxity (HP:0001388)1.82885840
134Impaired smooth pursuit (HP:0007772)1.82153699
135Arterial tortuosity (HP:0005116)1.82033699
136Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81971545
137Retinal atrophy (HP:0001105)1.81029966
138Abnormality of ocular smooth pursuit (HP:0000617)1.80709096
139Scanning speech (HP:0002168)1.80532489
140Sparse lateral eyebrow (HP:0005338)1.80089288
141Overgrowth (HP:0001548)1.78537712
142Impaired vibration sensation in the lower limbs (HP:0002166)1.76872000
143Widely spaced teeth (HP:0000687)1.76739049
144Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75571352
145Aplasia/Hypoplasia affecting the retina (HP:0008061)1.75335840
146Increased circulating renin level (HP:0000848)1.74424528
147Aplasia/Hypoplasia of the macula (HP:0008059)1.74068191
148Mild short stature (HP:0003502)1.73970902
149Hand muscle atrophy (HP:0009130)1.73862678
150Ankyloglossia (HP:0010296)1.73236385
151Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73101485
152Degeneration of the lateral corticospinal tracts (HP:0002314)1.73101485
153Soft skin (HP:0000977)1.72603584
154Abnormality of the acetabulum (HP:0003170)1.72297420
155Abnormality of the thoracic spine (HP:0100711)1.71967550
156Abnormality of oral frenula (HP:0000190)1.71807581
157Heterochromia iridis (HP:0001100)1.71493868
158Achilles tendon contracture (HP:0001771)1.71091384
159Dysostosis multiplex (HP:0000943)1.69597173
160Hyperextensible skin (HP:0000974)1.68227503
161Obsessive-compulsive behavior (HP:0000722)1.66947271
162Wide anterior fontanel (HP:0000260)1.66392316
163Spinal cord lesions (HP:0100561)1.65040775
164Syringomyelia (HP:0003396)1.65040775
165Eczematoid dermatitis (HP:0000976)1.65007059
166Abnormality of dentin (HP:0010299)1.64480430
167Dislocated radial head (HP:0003083)1.64002840
168Increased variability in muscle fiber diameter (HP:0003557)1.63978612
169Abnormality of the lumbar spine (HP:0100712)1.63784323
170Hemorrhage of the eye (HP:0011885)1.63284687
171Renal cell carcinoma (HP:0005584)1.63052827
172Coxa vara (HP:0002812)1.62115875
173Transitional cell carcinoma of the bladder (HP:0006740)1.62070733
174Abnormal hand bone ossification (HP:0010660)1.60986860
175Abnormality of the Achilles tendon (HP:0005109)1.60856266
176Abnormality of the distal phalanx of the thumb (HP:0009617)1.60824641
177Bowel diverticulosis (HP:0005222)1.60287420
178Emphysema (HP:0002097)1.59828798
179Advanced eruption of teeth (HP:0006288)1.59812810
180Abnormality of liposaccharide metabolism (HP:0010968)1.59481412
181Abnormality of glycosphingolipid metabolism (HP:0004343)1.59481412
182Abnormality of glycolipid metabolism (HP:0010969)1.59481412
183Insidious onset (HP:0003587)1.59420227
184Termporal pattern (HP:0011008)1.59420227
185Asymmetric septal hypertrophy (HP:0001670)1.59190827
186Bladder carcinoma (HP:0002862)1.58616386
187Bladder neoplasm (HP:0009725)1.58616386
188Arnold-Chiari malformation (HP:0002308)1.58270663
189Coarse hair (HP:0002208)1.57813301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK32.84414582
2CDK122.77463978
3PDGFRA2.75427607
4MAP3K92.57990471
5STK242.50624309
6MARK12.50246041
7PAK62.14322261
8SIK22.13849352
9NTRK22.11825611
10OXSR12.09669283
11RIPK42.02726361
12ERN12.02060648
13EPHA41.98127467
14FGFR41.95469521
15MAP3K101.88121309
16LATS21.87547144
17MINK11.87520157
18FES1.84414212
19NTRK11.82704494
20TNIK1.82642300
21MAP3K31.79953857
22CAMKK11.79708566
23CDK191.63652938
24STK391.62472530
25TTN1.62274849
26MAP3K41.61925732
27SMG11.61897590
28NEK91.57742584
29SIK11.56091989
30IRAK31.53373457
31SCYL21.51150748
32CAMK1G1.51040582
33DDR21.50047092
34EPHB11.48018772
35MST1R1.47416374
36WNK41.43988680
37CDK51.41870720
38LMTK21.39030588
39CDC42BPA1.37427714
40PTK21.34086089
41RIPK11.30607439
42MAP3K121.29880903
43MAP3K21.24728868
44DAPK21.23235872
45CAMKK21.22733430
46PKN21.19860981
47PRPF4B1.19322679
48TGFBR21.17863812
49SGK31.17040885
50KSR21.16150886
51MAP2K71.15902297
52BMX1.09851391
53RET1.08593698
54MAP3K141.08548585
55PAK41.05934524
56PRKD31.05037531
57DMPK1.04666495
58UHMK11.04035351
59SGK21.00601890
60MAP3K131.00430586
61FRK0.99910509
62MTOR0.97208657
63WNK10.96787698
64CLK10.95183229
65MET0.95133141
66TAOK30.93737531
67PRKCH0.93680365
68STK110.92398483
69JAK30.91523857
70ALK0.91093999
71PDK10.90813875
72FYN0.90242805
73JAK10.90041544
74TYRO30.89218822
75PLK20.88376467
76MAP3K70.86012364
77TRIB30.85833766
78SGK4940.85500688
79SGK2230.85500688
80MAPK130.85292560
81MELK0.82318374
82CDK150.81150621
83KSR10.80920147
84TAOK10.80074970
85CDK180.79800258
86MARK20.79627853
87MOS0.79195188
88PDPK10.79162095
89LATS10.79112816
90PAK20.75278108
91ICK0.73186531
92PNCK0.73057633
93STK380.72902624
94PTK60.72155148
95PAK30.72067379
96CAMK2B0.72019506
97MYLK0.70260495
98FGFR20.70225666
99TRPM70.70185246
100CDK60.69432120
101CDK140.68842881
102SGK10.67398748
103CDK11A0.67335094
104PDGFRB0.67108611
105EPHA20.67060199
106HCK0.66359541
107RPS6KL10.66332545
108RPS6KC10.66332545
109MAP2K30.66126720
110TXK0.66063067
111ARAF0.65825953
112CSNK1G20.65051084
113DAPK10.64595435
114HIPK20.63111271
115ZAP700.62305870
116ITK0.61987251
117MAP2K40.59792855
118BRD40.58471110
119ROCK20.56393106
120RPS6KA20.56333873
121TAOK20.56107753
122CAMK40.55438281
123FGFR30.55333484
124EEF2K0.54547917
125GRK70.54503362
126YES10.52675724
127MAPK110.52638373
128SYK0.51540608
129EPHA30.51468715
130SRC0.51346057
131BLK0.51107442
132KIT0.51066539
133CAMK1D0.49990424
134EPHB20.49802858
135JAK20.47933471
136MAP3K10.47579980
137CSNK1A1L0.47334480
138ERBB40.46962274
139ROCK10.46413900
140DYRK1B0.45032238
141RPS6KA60.44908114
142PTK2B0.44656015
143CSK0.44619689
144PRKCQ0.44252514
145CASK0.44073479
146MAPK120.43817688
147AKT30.43158486
148PRKD20.43068551
149FGR0.42749747
150MAPK100.42351863
151TYK20.41885343
152CSF1R0.41121573
153ILK0.37716564
154MAP3K60.36516315

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.01279029
2Nicotine addiction_Homo sapiens_hsa050331.99371492
3Long-term potentiation_Homo sapiens_hsa047201.80643840
4Other glycan degradation_Homo sapiens_hsa005111.79133606
5Olfactory transduction_Homo sapiens_hsa047401.77805705
6Circadian entrainment_Homo sapiens_hsa047131.76016707
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71260490
8Gastric acid secretion_Homo sapiens_hsa049711.71048301
9Glutamatergic synapse_Homo sapiens_hsa047241.69216261
10Morphine addiction_Homo sapiens_hsa050321.65313597
11Salivary secretion_Homo sapiens_hsa049701.62080052
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61628543
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57122819
14GABAergic synapse_Homo sapiens_hsa047271.55601175
15Axon guidance_Homo sapiens_hsa043601.51443046
16Renin secretion_Homo sapiens_hsa049241.49937340
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44564655
18Adherens junction_Homo sapiens_hsa045201.41371239
19Cholinergic synapse_Homo sapiens_hsa047251.36981528
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36847134
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35758772
22Dopaminergic synapse_Homo sapiens_hsa047281.34010355
23Amphetamine addiction_Homo sapiens_hsa050311.32228992
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31790160
25Long-term depression_Homo sapiens_hsa047301.31081502
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.28092012
27Glioma_Homo sapiens_hsa052141.26654647
28Prion diseases_Homo sapiens_hsa050201.26353967
29Insulin secretion_Homo sapiens_hsa049111.22351711
30Oxytocin signaling pathway_Homo sapiens_hsa049211.21943909
31Small cell lung cancer_Homo sapiens_hsa052221.21506278
32Dorso-ventral axis formation_Homo sapiens_hsa043201.21326162
33Acute myeloid leukemia_Homo sapiens_hsa052211.18140401
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17881508
35Bladder cancer_Homo sapiens_hsa052191.14938170
36Estrogen signaling pathway_Homo sapiens_hsa049151.14570456
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13624612
38GnRH signaling pathway_Homo sapiens_hsa049121.12260972
39Type II diabetes mellitus_Homo sapiens_hsa049301.11873637
40ErbB signaling pathway_Homo sapiens_hsa040121.11452225
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.08794399
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08682759
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08361597
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08155246
45Thyroid cancer_Homo sapiens_hsa052161.06709405
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.05626269
47Renal cell carcinoma_Homo sapiens_hsa052111.05378592
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.05310082
49cAMP signaling pathway_Homo sapiens_hsa040241.04323194
50Gap junction_Homo sapiens_hsa045401.04114549
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.03580431
52Cocaine addiction_Homo sapiens_hsa050301.03152666
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02370116
54MicroRNAs in cancer_Homo sapiens_hsa052061.02042281
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01536786
56Serotonergic synapse_Homo sapiens_hsa047261.00156384
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99841342
58Prostate cancer_Homo sapiens_hsa052150.99485612
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99286466
60Renin-angiotensin system_Homo sapiens_hsa046140.98569069
61Collecting duct acid secretion_Homo sapiens_hsa049660.97925936
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96120508
63Osteoclast differentiation_Homo sapiens_hsa043800.95784765
64Toxoplasmosis_Homo sapiens_hsa051450.95472295
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94659922
66Prolactin signaling pathway_Homo sapiens_hsa049170.93231978
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93197073
68Notch signaling pathway_Homo sapiens_hsa043300.93173027
69Non-small cell lung cancer_Homo sapiens_hsa052230.92214622
70VEGF signaling pathway_Homo sapiens_hsa043700.90010845
71Calcium signaling pathway_Homo sapiens_hsa040200.89916830
72Endocytosis_Homo sapiens_hsa041440.89531650
73Melanogenesis_Homo sapiens_hsa049160.88004377
74Taste transduction_Homo sapiens_hsa047420.87821730
75Chronic myeloid leukemia_Homo sapiens_hsa052200.87585922
76Thyroid hormone synthesis_Homo sapiens_hsa049180.87215223
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.86158309
78Lysosome_Homo sapiens_hsa041420.86135490
79Insulin signaling pathway_Homo sapiens_hsa049100.84866697
80Vibrio cholerae infection_Homo sapiens_hsa051100.84813297
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84743262
82Hepatitis B_Homo sapiens_hsa051610.84278381
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84150437
84B cell receptor signaling pathway_Homo sapiens_hsa046620.84107728
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84080382
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83108815
87Platelet activation_Homo sapiens_hsa046110.82955017
88Pancreatic cancer_Homo sapiens_hsa052120.82839514
89TNF signaling pathway_Homo sapiens_hsa046680.82707464
90Protein digestion and absorption_Homo sapiens_hsa049740.80124923
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79479774
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79224665
93Chemokine signaling pathway_Homo sapiens_hsa040620.78975241
94MAPK signaling pathway_Homo sapiens_hsa040100.78940125
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77875386
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77765516
97Inositol phosphate metabolism_Homo sapiens_hsa005620.77385936
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77097368
99T cell receptor signaling pathway_Homo sapiens_hsa046600.76134061
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75084033
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74805593
102Endometrial cancer_Homo sapiens_hsa052130.74436670
103Leishmaniasis_Homo sapiens_hsa051400.74337126
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.73833373
105Hepatitis C_Homo sapiens_hsa051600.73548588
106mTOR signaling pathway_Homo sapiens_hsa041500.73268072
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72449495
108AMPK signaling pathway_Homo sapiens_hsa041520.72233316
109Dilated cardiomyopathy_Homo sapiens_hsa054140.72201843
110Choline metabolism in cancer_Homo sapiens_hsa052310.71682779
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71251869
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70991806
113Focal adhesion_Homo sapiens_hsa045100.70140279
114Phagosome_Homo sapiens_hsa041450.70027723
115Rap1 signaling pathway_Homo sapiens_hsa040150.69891969
116Complement and coagulation cascades_Homo sapiens_hsa046100.68324608
117Pathways in cancer_Homo sapiens_hsa052000.67438553
118Tuberculosis_Homo sapiens_hsa051520.66731668
119Amoebiasis_Homo sapiens_hsa051460.66599886
120Apoptosis_Homo sapiens_hsa042100.66384183
121Shigellosis_Homo sapiens_hsa051310.66353402
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66320305
123Proteoglycans in cancer_Homo sapiens_hsa052050.66259455
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66030003
125FoxO signaling pathway_Homo sapiens_hsa040680.66011858
126HIF-1 signaling pathway_Homo sapiens_hsa040660.64974557
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.64765461
128Ras signaling pathway_Homo sapiens_hsa040140.63035381
129Pancreatic secretion_Homo sapiens_hsa049720.62934652
130Sphingolipid metabolism_Homo sapiens_hsa006000.62676799
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61994672
132Salmonella infection_Homo sapiens_hsa051320.61306802
133Influenza A_Homo sapiens_hsa051640.61291839
134Colorectal cancer_Homo sapiens_hsa052100.60092364
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.60034538
136Insulin resistance_Homo sapiens_hsa049310.59562707
137Hippo signaling pathway_Homo sapiens_hsa043900.59368831
138Pertussis_Homo sapiens_hsa051330.58499832
139ECM-receptor interaction_Homo sapiens_hsa045120.57282141

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