MGAT5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The MGAT5B gene encodes a beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.155) that functions in the synthesis of complex cell surface N-glycans (Kaneko et al., 2003 [PubMed 14623122]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.41431189
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.29345135
3locomotory exploration behavior (GO:0035641)6.27564525
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.92715548
5vocalization behavior (GO:0071625)5.72790117
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.60370000
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.59365467
8layer formation in cerebral cortex (GO:0021819)5.47989354
9regulation of glutamate receptor signaling pathway (GO:1900449)5.19622405
10regulation of synapse structural plasticity (GO:0051823)5.09079367
11synaptic vesicle exocytosis (GO:0016079)5.08813888
12protein localization to synapse (GO:0035418)4.99242777
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.98747467
14regulation of synaptic vesicle exocytosis (GO:2000300)4.97324644
15glutamate secretion (GO:0014047)4.94443092
16dendritic spine morphogenesis (GO:0060997)4.92222672
17neuron cell-cell adhesion (GO:0007158)4.88329403
18exploration behavior (GO:0035640)4.85547171
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.70870318
20regulation of neuronal synaptic plasticity (GO:0048168)4.66411217
21L-amino acid import (GO:0043092)4.64154977
22neurotransmitter secretion (GO:0007269)4.47801362
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.47650421
24neurotransmitter-gated ion channel clustering (GO:0072578)4.38922746
25amino acid import (GO:0043090)4.38491142
26cerebellar granule cell differentiation (GO:0021707)4.37194411
27regulation of synaptic vesicle transport (GO:1902803)4.37182713
28gamma-aminobutyric acid transport (GO:0015812)4.19965933
29regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.12719039
30positive regulation of synapse maturation (GO:0090129)4.12415565
31auditory behavior (GO:0031223)4.10657292
32synaptic transmission, glutamatergic (GO:0035249)4.06380557
33negative regulation of synaptic transmission, GABAergic (GO:0032229)4.03715684
34proline transport (GO:0015824)4.01761808
35regulation of dendritic spine morphogenesis (GO:0061001)4.01618781
36neuromuscular process controlling balance (GO:0050885)4.00009953
37negative regulation of dendrite morphogenesis (GO:0050774)3.97503524
38prepulse inhibition (GO:0060134)3.94381843
39neuron recognition (GO:0008038)3.92804126
40positive regulation of membrane potential (GO:0045838)3.87207372
41cell migration in hindbrain (GO:0021535)3.87098627
42dendrite morphogenesis (GO:0048813)3.86902473
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85940549
44long-term memory (GO:0007616)3.83289247
45glutamate receptor signaling pathway (GO:0007215)3.80761623
46axonal fasciculation (GO:0007413)3.80318920
47neuron-neuron synaptic transmission (GO:0007270)3.78618921
48neuronal action potential propagation (GO:0019227)3.73177091
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71823677
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.69740250
51positive regulation of synaptic transmission, GABAergic (GO:0032230)3.69501496
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.68024493
53regulation of voltage-gated calcium channel activity (GO:1901385)3.66838014
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.66597841
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.65358101
56potassium ion homeostasis (GO:0055075)3.64745170
57response to auditory stimulus (GO:0010996)3.64627655
58activation of protein kinase A activity (GO:0034199)3.60810890
59postsynaptic membrane organization (GO:0001941)3.60383857
60regulation of ARF protein signal transduction (GO:0032012)3.58105296
61regulation of postsynaptic membrane potential (GO:0060078)3.52205301
62regulation of synaptic plasticity (GO:0048167)3.52133702
63central nervous system projection neuron axonogenesis (GO:0021952)3.51319758
64transmission of nerve impulse (GO:0019226)3.49701644
65neurotransmitter transport (GO:0006836)3.47449172
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.46176992
67neuronal ion channel clustering (GO:0045161)3.43951629
68neuromuscular synaptic transmission (GO:0007274)3.39830053
69positive regulation of neurotransmitter secretion (GO:0001956)3.36816272
70cytoskeletal anchoring at plasma membrane (GO:0007016)3.36029585
71dopamine receptor signaling pathway (GO:0007212)3.35991279
72positive regulation of neurotransmitter transport (GO:0051590)3.35349579
73dendritic spine organization (GO:0097061)3.34561228
74regulation of neurotransmitter secretion (GO:0046928)3.33446069
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.33330960
76glycine transport (GO:0015816)3.32397209
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.31123208
78positive regulation of dendritic spine development (GO:0060999)3.29961042
79regulation of dendritic spine development (GO:0060998)3.27124021
80regulation of neurotransmitter levels (GO:0001505)3.26974979
81adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.26960473
82positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.25755781
83central nervous system myelination (GO:0022010)3.23763564
84axon ensheathment in central nervous system (GO:0032291)3.23763564
85cerebellar Purkinje cell layer development (GO:0021680)3.21909132
86synapse assembly (GO:0007416)3.21296331
87cellular potassium ion homeostasis (GO:0030007)3.20975863
88potassium ion import (GO:0010107)3.19750561
89pyrimidine nucleobase catabolic process (GO:0006208)3.17215199
90synaptic vesicle endocytosis (GO:0048488)3.17214365
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17115177
92sodium ion export (GO:0071436)3.16788083
93membrane depolarization during action potential (GO:0086010)3.16670341
94regulation of synaptic transmission (GO:0050804)3.16284764
95gamma-aminobutyric acid signaling pathway (GO:0007214)3.14807871
96phosphorelay signal transduction system (GO:0000160)3.13381032
97positive regulation of dendrite development (GO:1900006)3.12252408
98regulation of synapse maturation (GO:0090128)3.12228780
99neuromuscular process (GO:0050905)3.12124089
100cerebellar Purkinje cell differentiation (GO:0021702)3.10925209
101regulation of neurotransmitter transport (GO:0051588)3.10199703
102learning (GO:0007612)3.09427093
103regulation of dendrite morphogenesis (GO:0048814)3.09265392
104synaptic transmission (GO:0007268)3.06776042
105membrane hyperpolarization (GO:0060081)3.06731767
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06274680
107acidic amino acid transport (GO:0015800)3.04738946
108mechanosensory behavior (GO:0007638)3.04477064
109regulation of vesicle fusion (GO:0031338)3.04332975
110cell communication by electrical coupling (GO:0010644)3.03635527
111vesicle transport along microtubule (GO:0047496)3.03114456
112vesicle docking involved in exocytosis (GO:0006904)3.02764510
113regulation of female receptivity (GO:0045924)3.02592305
114mating behavior (GO:0007617)3.02033403
115social behavior (GO:0035176)3.01191565
116intraspecies interaction between organisms (GO:0051703)3.01191565
117neuromuscular process controlling posture (GO:0050884)3.00756911
118cellular sodium ion homeostasis (GO:0006883)3.00552358
119membrane depolarization (GO:0051899)3.00462816
120long-term synaptic potentiation (GO:0060291)2.99902025
121establishment of mitochondrion localization (GO:0051654)2.99030946
122chemosensory behavior (GO:0007635)2.96633350
123organelle transport along microtubule (GO:0072384)2.96185768
124establishment of synaptic vesicle localization (GO:0097480)2.95081733
125synaptic vesicle transport (GO:0048489)2.95081733
126behavioral fear response (GO:0001662)2.94927323
127behavioral defense response (GO:0002209)2.94927323
128synapse organization (GO:0050808)2.92321407
129cerebellum development (GO:0021549)2.90924802
130clathrin coat assembly (GO:0048268)2.90491109

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.11308259
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09379426
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05874726
4* RARB_27405468_Chip-Seq_BRAIN_Mouse2.99032646
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92007416
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.83603400
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80934360
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80934360
9GBX2_23144817_ChIP-Seq_PC3_Human2.80928304
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71841273
11DROSHA_22980978_ChIP-Seq_HELA_Human2.70991406
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.63308200
13* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.57791491
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51815183
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.51081608
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48772530
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48213069
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.44816404
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44261767
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42658253
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.41589136
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40078144
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.39325316
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38083714
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.33203653
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.32614852
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18100439
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.14433506
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07448553
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99685960
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.93019550
32AR_21572438_ChIP-Seq_LNCaP_Human1.83098620
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76247517
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70635753
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.59182583
36KDM2B_26808549_Chip-Seq_K562_Human1.58033846
37* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51938874
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49665171
39LXR_22292898_ChIP-Seq_THP-1_Human1.46168608
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46076218
41RING1B_27294783_Chip-Seq_NPCs_Mouse1.44515851
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41144653
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40348598
44ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38823320
45* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33966336
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.31533237
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30312606
48* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28394417
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28376342
50* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28249555
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26064453
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25436168
53SMAD4_21799915_ChIP-Seq_A2780_Human1.24544159
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23407019
55RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23134053
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23036977
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22251939
58ZNF274_21170338_ChIP-Seq_K562_Hela1.21916587
59* AR_19668381_ChIP-Seq_PC3_Human1.21745113
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19948750
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18757959
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17392347
63* SMC4_20622854_ChIP-Seq_HELA_Human1.16769744
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.13391369
65OCT4_19829295_ChIP-Seq_ESCs_Human1.12532135
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10929109
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.10695719
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09775119
69P68_20966046_ChIP-Seq_HELA_Human1.08746208
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08450695
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07205510
72SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06598116
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.06053576
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05297099
75* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05049839
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.03898247
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03249572
78* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03036082
79CTCF_27219007_Chip-Seq_Bcells_Human1.02221368
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02205838
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00982593
82RNF2_27304074_Chip-Seq_NSC_Mouse1.00465301
83CREB1_26743006_Chip-Seq_LNCaP_Human1.00267896
84* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99818756
85STAT3_23295773_ChIP-Seq_U87_Human0.99340824
86AHR_22903824_ChIP-Seq_MCF-7_Human0.98888624
87TET1_21490601_ChIP-Seq_MESCs_Mouse0.98340654
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97498332
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96329602
90ARNT_22903824_ChIP-Seq_MCF-7_Human0.96327634
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.96155955
92AR_25329375_ChIP-Seq_VCAP_Human0.95801085
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94900022
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.93860411
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93745957
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93538777
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93123586
98SMAD_19615063_ChIP-ChIP_OVARY_Human0.91994203
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91591760
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.91565008
101KDM2B_26808549_Chip-Seq_DND41_Human0.91514591
102TAF15_26573619_Chip-Seq_HEK293_Human0.90640584
103MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90209884
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89007515
105TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88300684
106KDM2B_26808549_Chip-Seq_JURKAT_Human0.87738570
107BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87476082
108* TP53_20018659_ChIP-ChIP_R1E_Mouse0.87404804
109P300_19829295_ChIP-Seq_ESCs_Human0.86851080
110* TCF4_23295773_ChIP-Seq_U87_Human0.86339073
111DPY_21335234_ChIP-Seq_ESCs_Mouse0.86020349
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85812725
113TP53_23651856_ChIP-Seq_MEFs_Mouse0.83824642
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83524386
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82559370
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82559370
117SMAD4_21741376_ChIP-Seq_ESCs_Human0.81772342
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81491757
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81008692
120* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80822821
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80820157
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.79851313
123ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78190372
124SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.78007395
125TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.77923406
126CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77858537
127KLF4_19829295_ChIP-Seq_ESCs_Human0.77426514
128NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.75674537
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73820093
130* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73178694
131SOX3_22085726_ChIP-Seq_NPCs_Mouse0.71531547
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.69974515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.90166682
2MP0003880_abnormal_central_pattern4.29732881
3MP0003635_abnormal_synaptic_transmissio4.21200271
4MP0002822_catalepsy3.90873171
5MP0004270_analgesia3.88223046
6MP0005423_abnormal_somatic_nervous3.49905763
7MP0002063_abnormal_learning/memory/cond3.46087491
8MP0009745_abnormal_behavioral_response3.33675663
9MP0002064_seizures2.96439216
10MP0009046_muscle_twitch2.83581516
11MP0002572_abnormal_emotion/affect_behav2.71829620
12MP0001968_abnormal_touch/_nociception2.64337919
13MP0002734_abnormal_mechanical_nocicepti2.64238308
14MP0001486_abnormal_startle_reflex2.60530867
15MP0000778_abnormal_nervous_system2.31923947
16MP0002272_abnormal_nervous_system2.27442498
17MP0004811_abnormal_neuron_physiology2.06808436
18MP0004858_abnormal_nervous_system2.05378017
19MP0002733_abnormal_thermal_nociception2.03570786
20MP0002184_abnormal_innervation1.98300520
21MP0009780_abnormal_chondrocyte_physiolo1.98020124
22MP0002557_abnormal_social/conspecific_i1.90393625
23MP0001440_abnormal_grooming_behavior1.88372320
24MP0001970_abnormal_pain_threshold1.87937651
25MP0002909_abnormal_adrenal_gland1.87118916
26MP0002736_abnormal_nociception_after1.85081997
27MP0001501_abnormal_sleep_pattern1.84909939
28MP0004885_abnormal_endolymph1.84483364
29MP0008569_lethality_at_weaning1.82422814
30MP0002735_abnormal_chemical_nociception1.81547522
31MP0000955_abnormal_spinal_cord1.79774784
32MP0005386_behavior/neurological_phenoty1.76341448
33MP0004924_abnormal_behavior1.76341448
34MP0002067_abnormal_sensory_capabilities1.73201279
35MP0003123_paternal_imprinting1.70589086
36MP0003329_amyloid_beta_deposits1.67908458
37MP0001984_abnormal_olfaction1.65814985
38MP0003787_abnormal_imprinting1.62105881
39MP0002882_abnormal_neuron_morphology1.54682880
40MP0003879_abnormal_hair_cell1.50713229
41MP0005646_abnormal_pituitary_gland1.45790535
42MP0002066_abnormal_motor_capabilities/c1.43841120
43MP0002152_abnormal_brain_morphology1.35114760
44MP0005645_abnormal_hypothalamus_physiol1.30610388
45MP0006276_abnormal_autonomic_nervous1.29338497
46MP0001529_abnormal_vocalization1.28165390
47MP0003633_abnormal_nervous_system1.25244440
48MP0005499_abnormal_olfactory_system1.24370395
49MP0005394_taste/olfaction_phenotype1.24370395
50MP0003283_abnormal_digestive_organ1.22819188
51MP0000569_abnormal_digit_pigmentation1.22168776
52MP0001177_atelectasis1.07990612
53MP0008961_abnormal_basal_metabolism1.07125966
54MP0003631_nervous_system_phenotype1.05970708
55MP0004142_abnormal_muscle_tone1.04193172
56MP0001502_abnormal_circadian_rhythm1.01151773
57MP0000631_abnormal_neuroendocrine_gland0.99883605
58MP0003861_abnormal_nervous_system0.97118591
59MP0002069_abnormal_eating/drinking_beha0.97044600
60MP0001905_abnormal_dopamine_level0.93179285
61MP0000579_abnormal_nail_morphology0.88979765
62MP0000751_myopathy0.87468890
63MP0008872_abnormal_physiological_respon0.87341346
64MP0003075_altered_response_to0.85801330
65MP0003634_abnormal_glial_cell0.85602213
66MP0001346_abnormal_lacrimal_gland0.85408999
67MP0003121_genomic_imprinting0.84484006
68MP0001188_hyperpigmentation0.84368747
69MP0008874_decreased_physiological_sensi0.82988933
70MP0005187_abnormal_penis_morphology0.82730402
71MP0002229_neurodegeneration0.81883063
72MP0002752_abnormal_somatic_nervous0.81758377
73MP0004085_abnormal_heartbeat0.80334804
74MP0004742_abnormal_vestibular_system0.80003331
75MP0002638_abnormal_pupillary_reflex0.79911760
76MP0003122_maternal_imprinting0.79414572
77MP0005167_abnormal_blood-brain_barrier0.76711019
78MP0003632_abnormal_nervous_system0.76003446
79MP0010234_abnormal_vibrissa_follicle0.74639022
80MP0002653_abnormal_ependyma_morphology0.73505525
81MP0005623_abnormal_meninges_morphology0.73197910
82MP0005409_darkened_coat_color0.72852223
83MP0002089_abnormal_postnatal_growth/wei0.72395124
84MP0003137_abnormal_impulse_conducting0.72159575
85MP0001348_abnormal_lacrimal_gland0.71456083
86MP0002249_abnormal_larynx_morphology0.70065095
87MP0001963_abnormal_hearing_physiology0.69830769
88MP0003690_abnormal_glial_cell0.69667291
89MP0006292_abnormal_olfactory_placode0.69491132
90MP0010386_abnormal_urinary_bladder0.68872809
91MP0008789_abnormal_olfactory_epithelium0.67458215
92MP0008877_abnormal_DNA_methylation0.65949277
93MP0000537_abnormal_urethra_morphology0.64311674
94MP0005551_abnormal_eye_electrophysiolog0.64283798
95MP0010769_abnormal_survival0.63368996
96MP0005535_abnormal_body_temperature0.62913779
97MP0002090_abnormal_vision0.62904034
98MP0000026_abnormal_inner_ear0.62196484
99MP0000604_amyloidosis0.61716216
100MP0001943_abnormal_respiration0.61715721
101MP0010770_preweaning_lethality0.60954390
102MP0002082_postnatal_lethality0.60954390
103MP0003119_abnormal_digestive_system0.60854960
104MP0001485_abnormal_pinna_reflex0.60597885
105MP0000566_synostosis0.60202696
106MP0000920_abnormal_myelination0.60200625
107MP0010768_mortality/aging0.59616031
108MP0001299_abnormal_eye_distance/0.58332250
109MP0004233_abnormal_muscle_weight0.58172312
110MP0002081_perinatal_lethality0.57640545
111MP0000534_abnormal_ureter_morphology0.57377378
112MP0005171_absent_coat_pigmentation0.56539191
113MP0002234_abnormal_pharynx_morphology0.54640136
114MP0003938_abnormal_ear_development0.53925302
115MP0004130_abnormal_muscle_cell0.53805241
116MP0003956_abnormal_body_size0.50673946
117MP0003172_abnormal_lysosome_physiology0.49905984

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.04528250
2Focal motor seizures (HP:0011153)6.01236744
3Focal seizures (HP:0007359)5.02761738
4Visual hallucinations (HP:0002367)4.64244578
5Epileptic encephalopathy (HP:0200134)4.01615552
6Ankle clonus (HP:0011448)3.89837442
7Supranuclear gaze palsy (HP:0000605)3.76375450
8Mutism (HP:0002300)3.58554269
9Poor eye contact (HP:0000817)3.58505515
10Action tremor (HP:0002345)3.56045732
11Progressive cerebellar ataxia (HP:0002073)3.54906843
12Broad-based gait (HP:0002136)3.44025456
13Abnormality of the lower motor neuron (HP:0002366)3.39202505
14Impaired vibration sensation in the lower limbs (HP:0002166)3.26269930
15Urinary bladder sphincter dysfunction (HP:0002839)3.26072533
16Papilledema (HP:0001085)3.22186448
17Impaired social interactions (HP:0000735)3.22146541
18Abnormal social behavior (HP:0012433)3.22146541
19Febrile seizures (HP:0002373)3.21665070
20Depression (HP:0000716)3.16126740
21Generalized tonic-clonic seizures (HP:0002069)3.11293888
22Torticollis (HP:0000473)3.10131973
23Absence seizures (HP:0002121)3.07088418
24Atonic seizures (HP:0010819)3.02259393
25Limb dystonia (HP:0002451)3.00566766
26Urinary urgency (HP:0000012)3.00515584
27Amyotrophic lateral sclerosis (HP:0007354)2.96843832
28Cerebral hypomyelination (HP:0006808)2.87870644
29Insomnia (HP:0100785)2.85221667
30Dysdiadochokinesis (HP:0002075)2.84079049
31Genetic anticipation (HP:0003743)2.82907504
32Tetraplegia (HP:0002445)2.80756971
33Obstructive sleep apnea (HP:0002870)2.80384388
34Dialeptic seizures (HP:0011146)2.79346830
35Postural instability (HP:0002172)2.78148619
36Anxiety (HP:0000739)2.76231316
37Focal dystonia (HP:0004373)2.76120552
38Pointed chin (HP:0000307)2.74448864
39Megalencephaly (HP:0001355)2.73609427
40Gaze-evoked nystagmus (HP:0000640)2.71357428
41Delusions (HP:0000746)2.67754881
42Spastic gait (HP:0002064)2.66280520
43Drooling (HP:0002307)2.66107671
44Excessive salivation (HP:0003781)2.66107671
45Abnormal eating behavior (HP:0100738)2.62038352
46Hemiparesis (HP:0001269)2.60692038
47Abnormality of the corticospinal tract (HP:0002492)2.60162150
48Amblyopia (HP:0000646)2.60126117
49Annular pancreas (HP:0001734)2.57578537
50Stereotypic behavior (HP:0000733)2.56520969
51Craniofacial dystonia (HP:0012179)2.52515206
52Dysmetria (HP:0001310)2.51087430
53Neurofibrillary tangles (HP:0002185)2.46921458
54Cerebral inclusion bodies (HP:0100314)2.44228112
55Truncal ataxia (HP:0002078)2.43756603
56Progressive inability to walk (HP:0002505)2.41313451
57Hyperventilation (HP:0002883)2.40743595
58Termporal pattern (HP:0011008)2.40470103
59Insidious onset (HP:0003587)2.40470103
60Intention tremor (HP:0002080)2.40199018
61Impaired smooth pursuit (HP:0007772)2.39308303
62Inappropriate behavior (HP:0000719)2.34591640
63Lower limb muscle weakness (HP:0007340)2.34242096
64Bradykinesia (HP:0002067)2.29791449
65Hyperacusis (HP:0010780)2.26338153
66Diplopia (HP:0000651)2.25801268
67Abnormality of binocular vision (HP:0011514)2.25801268
68Fetal akinesia sequence (HP:0001989)2.24519297
69Apathy (HP:0000741)2.22953179
70Hemiplegia (HP:0002301)2.21740302
71Ankyloglossia (HP:0010296)2.21696850
72EEG with generalized epileptiform discharges (HP:0011198)2.18022295
73Peripheral hypomyelination (HP:0007182)2.17055246
74Lower limb amyotrophy (HP:0007210)2.16739555
75Hypsarrhythmia (HP:0002521)2.16495817
76Epileptiform EEG discharges (HP:0011182)2.15965153
77Ventricular fibrillation (HP:0001663)2.12557336
78Abnormality of ocular smooth pursuit (HP:0000617)2.11816484
79Spastic tetraparesis (HP:0001285)2.11705597
80Elfin facies (HP:0004428)2.10619764
81Impaired vibratory sensation (HP:0002495)2.08678025
82Turricephaly (HP:0000262)2.08355656
83Upper limb amyotrophy (HP:0009129)2.08140649
84Distal upper limb amyotrophy (HP:0007149)2.08140649
85Akinesia (HP:0002304)2.06003110
86Hand muscle atrophy (HP:0009130)2.05945979
87Clonus (HP:0002169)2.05685397
88Aplasia involving bones of the extremities (HP:0009825)2.05539409
89Aplasia involving bones of the upper limbs (HP:0009823)2.05539409
90Aplasia of the phalanges of the hand (HP:0009802)2.05539409
91Absent speech (HP:0001344)2.03266463
92Scanning speech (HP:0002168)2.02694153
93Rigidity (HP:0002063)2.02433848
94Spinal canal stenosis (HP:0003416)2.02253675
95Aqueductal stenosis (HP:0002410)2.00623151
96Overriding aorta (HP:0002623)1.97348114
97Diminished motivation (HP:0000745)1.96839376
98Agitation (HP:0000713)1.95118007
99Resting tremor (HP:0002322)1.93555545
100Polyphagia (HP:0002591)1.93132477
101Rapidly progressive (HP:0003678)1.88798178
102CNS hypomyelination (HP:0003429)1.87030374
103Dysmetric saccades (HP:0000641)1.86515757
104Bronchomalacia (HP:0002780)1.86376459
105Neuronal loss in central nervous system (HP:0002529)1.85103257
106Sleep apnea (HP:0010535)1.85016353
107Incomplete penetrance (HP:0003829)1.83682764
108Intellectual disability, profound (HP:0002187)1.83323858
109Inability to walk (HP:0002540)1.81998170
110Status epilepticus (HP:0002133)1.81958048
111Lower limb asymmetry (HP:0100559)1.79677817
112Hypoplasia of the brainstem (HP:0002365)1.78444537
113Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78444537
114Choreoathetosis (HP:0001266)1.77119569
115Morphological abnormality of the pyramidal tract (HP:0002062)1.75064270
116Pachygyria (HP:0001302)1.74966014
117Lissencephaly (HP:0001339)1.74323670
118Generalized myoclonic seizures (HP:0002123)1.73500795
119Heterochromia iridis (HP:0001100)1.71362159
120Bowel incontinence (HP:0002607)1.69588605
121Hyperthyroidism (HP:0000836)1.67415423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.07149431
2EPHA44.46126891
3MAP3K94.05699655
4NTRK33.76140314
5DAPK22.91534666
6MINK12.72932844
7MAP3K42.59542598
8NTRK22.42957883
9PAK62.34502764
10PRKD32.29702088
11CAMKK12.08961138
12KSR21.99681039
13SIK21.89413955
14MAP2K71.88419493
15KSR11.79914175
16NTRK11.78000526
17CDK51.61544992
18TYRO31.58875670
19DAPK11.55382592
20TAOK11.53604172
21MAPK131.52603593
22PHKG11.50239172
23PHKG21.50239172
24LATS21.43449619
25MAP2K41.43232239
26UHMK11.37200200
27TNIK1.34934807
28PRPF4B1.18175778
29NEK61.16701939
30STK381.16381643
31PNCK1.14618446
32ALK1.13803110
33MAP3K21.13024343
34STK111.07400768
35PRKCG1.04331793
36CASK1.03795102
37RIPK41.00310929
38FES0.99328026
39CDK150.98731191
40CDK180.97702192
41MAP3K120.97488589
42RIPK10.96503457
43PLK20.94574474
44GRK50.93817233
45CDK140.92440578
46MARK20.90424238
47ERBB30.89939985
48CSNK1G20.88385101
49RET0.87679982
50CDK11A0.87186943
51CDK190.85791812
52PRKCH0.82139344
53SGK2230.78018432
54SGK4940.78018432
55DYRK20.77883520
56BRAF0.77677614
57MAPK120.77373449
58CAMK2G0.74561738
59TESK10.72889037
60CAMK10.70804816
61CAMK2A0.69495591
62PRKCZ0.69472561
63PAK30.68099714
64MAP3K110.67222363
65DYRK1A0.67205480
66NEK10.67196510
67ICK0.63914759
68SGK10.62571510
69PINK10.61832319
70CAMKK20.60829662
71SGK30.60489666
72ARAF0.59187725
73SGK20.58029399
74RAF10.58015568
75SCYL20.57263899
76CAMK1D0.57096762
77LMTK20.56671747
78BRSK10.52849151
79CDC42BPA0.52040320
80TRIB30.51476507
81DDR20.51170771
82RPS6KA20.50041059
83RPS6KA30.50026589
84PTK20.48975790
85CAMK2B0.48582031
86FYN0.47872621
87MAP2K60.47544200
88OXSR10.47490868
89PDGFRA0.46420188
90MAP3K130.46290607
91PDK10.45406335
92DAPK30.45108425
93MAPK100.44889919
94PDPK10.44142795
95TAOK20.42690711
96CAMK1G0.42417100
97CCNB10.41805338
98MAP3K60.40959314
99CAMK40.40911665
100EPHB20.39803095
101FGFR20.39752102
102CAMK2D0.38849898
103CSNK1A1L0.38268241
104CSNK1G30.37668462
105PKN10.37631373
106ROCK20.36179795
107MAPK80.36008840
108PRKG20.33763101
109DMPK0.33369674
110AURKA0.32634151
111GSK3B0.32322389
112CSNK1D0.30716988
113MAP2K10.30584469
114MAPK90.29662134
115LIMK10.29488486
116ROCK10.29249199
117CSNK1E0.27372593
118PRKCI0.27191455
119PRKCA0.26510747
120ERBB20.22961754

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.17657776
2Synaptic vesicle cycle_Homo sapiens_hsa047213.11487666
3Olfactory transduction_Homo sapiens_hsa047403.11062430
4Circadian entrainment_Homo sapiens_hsa047132.62433262
5GABAergic synapse_Homo sapiens_hsa047272.62189225
6Glutamatergic synapse_Homo sapiens_hsa047242.50054109
7Morphine addiction_Homo sapiens_hsa050322.49024936
8Long-term potentiation_Homo sapiens_hsa047202.45160081
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37660932
10Amphetamine addiction_Homo sapiens_hsa050312.36393962
11Dopaminergic synapse_Homo sapiens_hsa047282.27486184
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16385766
13Cholinergic synapse_Homo sapiens_hsa047252.05525754
14Salivary secretion_Homo sapiens_hsa049701.94342428
15Cocaine addiction_Homo sapiens_hsa050301.93752986
16Vitamin B6 metabolism_Homo sapiens_hsa007501.87873113
17Insulin secretion_Homo sapiens_hsa049111.83210156
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81753614
19Gastric acid secretion_Homo sapiens_hsa049711.80394093
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75656330
21Oxytocin signaling pathway_Homo sapiens_hsa049211.66546664
22Renin secretion_Homo sapiens_hsa049241.60728104
23Long-term depression_Homo sapiens_hsa047301.57566633
24Gap junction_Homo sapiens_hsa045401.57156718
25Axon guidance_Homo sapiens_hsa043601.54465995
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54199296
27GnRH signaling pathway_Homo sapiens_hsa049121.52202476
28Taste transduction_Homo sapiens_hsa047421.52058500
29Serotonergic synapse_Homo sapiens_hsa047261.51225136
30Calcium signaling pathway_Homo sapiens_hsa040201.40950392
31Glioma_Homo sapiens_hsa052141.36511485
32Estrogen signaling pathway_Homo sapiens_hsa049151.30606479
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29925368
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27596557
35cAMP signaling pathway_Homo sapiens_hsa040241.24922564
36Type II diabetes mellitus_Homo sapiens_hsa049301.24332829
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22840721
38ErbB signaling pathway_Homo sapiens_hsa040121.21439948
39Melanogenesis_Homo sapiens_hsa049161.16259105
40Nitrogen metabolism_Homo sapiens_hsa009101.13282117
41Oocyte meiosis_Homo sapiens_hsa041141.05058669
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02253036
43Dorso-ventral axis formation_Homo sapiens_hsa043200.96547876
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95408146
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.94347218
46Endometrial cancer_Homo sapiens_hsa052130.92260634
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90957065
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.88338587
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87638839
50MAPK signaling pathway_Homo sapiens_hsa040100.80838987
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.80096187
52Alcoholism_Homo sapiens_hsa050340.78721697
53Choline metabolism in cancer_Homo sapiens_hsa052310.78538571
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76841626
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76777120
56VEGF signaling pathway_Homo sapiens_hsa043700.76746018
57mTOR signaling pathway_Homo sapiens_hsa041500.76600071
58Collecting duct acid secretion_Homo sapiens_hsa049660.76072082
59Rap1 signaling pathway_Homo sapiens_hsa040150.74824161
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74042563
61Dilated cardiomyopathy_Homo sapiens_hsa054140.73551520
62Non-small cell lung cancer_Homo sapiens_hsa052230.71221868
63Phototransduction_Homo sapiens_hsa047440.70976218
64Cardiac muscle contraction_Homo sapiens_hsa042600.68231753
65Ras signaling pathway_Homo sapiens_hsa040140.66471275
66Colorectal cancer_Homo sapiens_hsa052100.66454139
67Thyroid hormone synthesis_Homo sapiens_hsa049180.65254225
68Renal cell carcinoma_Homo sapiens_hsa052110.63660528
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.62862378
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62698739
71Wnt signaling pathway_Homo sapiens_hsa043100.62676697
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62301995
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60872786
74Pancreatic secretion_Homo sapiens_hsa049720.60754025
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60536098
76Endocytosis_Homo sapiens_hsa041440.60082527
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59157151
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57206750
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54146223
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53444900
81Insulin signaling pathway_Homo sapiens_hsa049100.53101096
82Glucagon signaling pathway_Homo sapiens_hsa049220.52161913
83* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51755039
84Vibrio cholerae infection_Homo sapiens_hsa051100.51574745
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50453774
86Prion diseases_Homo sapiens_hsa050200.50177350
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48786723
88Hippo signaling pathway_Homo sapiens_hsa043900.48412361
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47571178
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47456061
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47144640
92Arginine biosynthesis_Homo sapiens_hsa002200.46892194
93Tight junction_Homo sapiens_hsa045300.45313449
94Chemokine signaling pathway_Homo sapiens_hsa040620.45180589
95Bile secretion_Homo sapiens_hsa049760.44960119
96Type I diabetes mellitus_Homo sapiens_hsa049400.44590929
97Hedgehog signaling pathway_Homo sapiens_hsa043400.44230664
98Prolactin signaling pathway_Homo sapiens_hsa049170.39128173
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38242373
100AMPK signaling pathway_Homo sapiens_hsa041520.37070850
101Fatty acid biosynthesis_Homo sapiens_hsa000610.36957463
102Inositol phosphate metabolism_Homo sapiens_hsa005620.34604719
103Circadian rhythm_Homo sapiens_hsa047100.34024523
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33903782
105Ovarian steroidogenesis_Homo sapiens_hsa049130.33015010
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32653922
107Arginine and proline metabolism_Homo sapiens_hsa003300.31156288
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.31102043
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30495227
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27865157

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