MGLL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)4.20763983
2low-density lipoprotein particle clearance (GO:0034383)4.16980340
3fatty-acyl-CoA biosynthetic process (GO:0046949)4.14837386
4long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.07597751
5regulation of sequestering of triglyceride (GO:0010889)4.07133663
6acyl-CoA biosynthetic process (GO:0071616)4.00269847
7thioester biosynthetic process (GO:0035384)4.00269847
8barbed-end actin filament capping (GO:0051016)3.97710850
9fatty acid elongation (GO:0030497)3.95155301
10fatty-acyl-CoA metabolic process (GO:0035337)3.92926149
11acetyl-CoA metabolic process (GO:0006084)3.78861672
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.76044926
13L-phenylalanine catabolic process (GO:0006559)3.76044926
14long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.75233832
15fatty acid beta-oxidation (GO:0006635)3.73905519
16fatty acid transmembrane transport (GO:1902001)3.70037154
17biotin metabolic process (GO:0006768)3.64342729
18triglyceride biosynthetic process (GO:0019432)3.61527066
19positive regulation of fatty acid beta-oxidation (GO:0032000)3.52376433
20neutral lipid biosynthetic process (GO:0046460)3.52286198
21acylglycerol biosynthetic process (GO:0046463)3.52286198
22plasma lipoprotein particle clearance (GO:0034381)3.48916008
23fatty acid catabolic process (GO:0009062)3.48720590
24short-chain fatty acid metabolic process (GO:0046459)3.40571454
25fatty acid oxidation (GO:0019395)3.40534376
26very long-chain fatty acid metabolic process (GO:0000038)3.40510824
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.39113037
28L-phenylalanine metabolic process (GO:0006558)3.39113037
29lipid oxidation (GO:0034440)3.38468832
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.37465438
31positive regulation of fatty acid oxidation (GO:0046321)3.33240361
32regulation of triglyceride catabolic process (GO:0010896)3.32492714
33* triglyceride catabolic process (GO:0019433)3.31064583
34carnitine shuttle (GO:0006853)3.30140696
35response to dietary excess (GO:0002021)3.28775592
36central nervous system myelination (GO:0022010)3.28317120
37axon ensheathment in central nervous system (GO:0032291)3.28317120
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.27468226
39* neutral lipid catabolic process (GO:0046461)3.21564062
40* acylglycerol catabolic process (GO:0046464)3.21564062
41virion attachment to host cell (GO:0019062)3.21052183
42adhesion of symbiont to host cell (GO:0044650)3.21052183
43thioester metabolic process (GO:0035383)3.20237113
44acyl-CoA metabolic process (GO:0006637)3.20237113
45cellular ketone body metabolic process (GO:0046950)3.10890285
46monocarboxylic acid catabolic process (GO:0072329)3.09736383
47positive regulation of lipid catabolic process (GO:0050996)3.05684653
48positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.04721699
49sulfur amino acid catabolic process (GO:0000098)2.99192291
50regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.98055462
51* triglyceride metabolic process (GO:0006641)2.96029239
52adhesion of symbiont to host (GO:0044406)2.88635767
53creatine metabolic process (GO:0006600)2.88052661
54branched-chain amino acid catabolic process (GO:0009083)2.86623328
55stress fiber assembly (GO:0043149)2.85389378
56negative regulation of homotypic cell-cell adhesion (GO:0034111)2.84653896
57* glycerolipid catabolic process (GO:0046503)2.83179102
58complement activation, alternative pathway (GO:0006957)2.82542610
59bile acid biosynthetic process (GO:0006699)2.81945667
60negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.81015072
61triglyceride homeostasis (GO:0070328)2.80524189
62acylglycerol homeostasis (GO:0055090)2.80524189
63valine metabolic process (GO:0006573)2.80462329
64ketone body metabolic process (GO:1902224)2.79597075
65* acylglycerol metabolic process (GO:0006639)2.79120558
66protein localization to endosome (GO:0036010)2.78971724
67carnitine transmembrane transport (GO:1902603)2.78577899
68brown fat cell differentiation (GO:0050873)2.78364682
69aromatic amino acid family catabolic process (GO:0009074)2.77280188
70* neutral lipid metabolic process (GO:0006638)2.76676173
71regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.72725721
72regulation of fatty acid oxidation (GO:0046320)2.72671593
73regulation of integrin-mediated signaling pathway (GO:2001044)2.72296951
74cellular response to thyroid hormone stimulus (GO:0097067)2.70885561
75cysteine metabolic process (GO:0006534)2.70571963
76negative regulation of lipase activity (GO:0060192)2.69393341
77negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.68153771
78positive regulation of endothelial cell apoptotic process (GO:2000353)2.67142195
79positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.66311797
80amino-acid betaine transport (GO:0015838)2.65828098
81carnitine transport (GO:0015879)2.65828098
82cellular response to epinephrine stimulus (GO:0071872)2.65671332
83regulation of membrane protein ectodomain proteolysis (GO:0051043)2.64930292
84branched-chain amino acid metabolic process (GO:0009081)2.64568426
85response to methylmercury (GO:0051597)2.64505219
86regulation of fatty acid beta-oxidation (GO:0031998)2.61993031
87regulation of triglyceride metabolic process (GO:0090207)2.61865780
88positive regulation of lipoprotein lipase activity (GO:0051006)2.60573830
89positive regulation of triglyceride lipase activity (GO:0061365)2.60573830
90negative regulation of smooth muscle cell migration (GO:0014912)2.60538245
91glycosphingolipid catabolic process (GO:0046479)2.59917812
92negative regulation of nitric oxide biosynthetic process (GO:0045019)2.59662444
93fibril organization (GO:0097435)2.59179070
94extracellular fibril organization (GO:0043206)2.58961007
95regulation of cholesterol metabolic process (GO:0090181)2.58322386
96regulation of macrophage chemotaxis (GO:0010758)2.57478764
97glyoxylate metabolic process (GO:0046487)2.57234029
98amino-acid betaine metabolic process (GO:0006577)2.57133434
99lipid storage (GO:0019915)2.56916810
100ethanol oxidation (GO:0006069)2.56723631
101apoptotic cell clearance (GO:0043277)2.56345827
102regulation of lipoprotein metabolic process (GO:0050746)2.55551634
103positive regulation of fatty acid metabolic process (GO:0045923)2.55249440
104coenzyme catabolic process (GO:0009109)2.53746126
105cGMP-mediated signaling (GO:0019934)2.53679440
106bile acid metabolic process (GO:0008206)2.53072574
107succinate metabolic process (GO:0006105)2.52854404
108regulation of mononuclear cell migration (GO:0071675)2.52208277
109adenosine receptor signaling pathway (GO:0001973)2.51888984
110angiogenesis involved in wound healing (GO:0060055)2.51764180
111axon ensheathment (GO:0008366)2.51347155
112ensheathment of neurons (GO:0007272)2.51347155
113myelination (GO:0042552)2.51277749
114NADH metabolic process (GO:0006734)2.50297300
115regulation of early endosome to late endosome transport (GO:2000641)2.50156248
116positive regulation of triglyceride metabolic process (GO:0090208)2.49589578
117regulation of cholesterol storage (GO:0010885)2.49172736
118tyrosine metabolic process (GO:0006570)2.49045662
119glycerol metabolic process (GO:0006071)2.47575586
120lysine catabolic process (GO:0006554)2.46973461
121lysine metabolic process (GO:0006553)2.46973461
122carboxylic acid catabolic process (GO:0046395)2.46694522
123organic acid catabolic process (GO:0016054)2.46694522
124positive regulation of receptor recycling (GO:0001921)2.46478353
125regulation of platelet aggregation (GO:0090330)2.45404188
126positive regulation of extracellular matrix organization (GO:1903055)2.45078633
127regulation of macrophage derived foam cell differentiation (GO:0010743)2.44398603
128aspartate family amino acid catabolic process (GO:0009068)2.44365342
129lipid particle organization (GO:0034389)2.43987145
130import into cell (GO:0098657)2.43952873
131positive regulation of cholesterol efflux (GO:0010875)2.41838940
132white fat cell differentiation (GO:0050872)2.41802262
133positive regulation of macrophage cytokine production (GO:0060907)2.41601986
134negative regulation of platelet activation (GO:0010544)2.41538122
135cholesterol biosynthetic process (GO:0006695)2.40933669
136linoleic acid metabolic process (GO:0043651)2.40733546
137regulation of triglyceride biosynthetic process (GO:0010866)2.40272164
138glutamate metabolic process (GO:0006536)2.40122321
139cyclooxygenase pathway (GO:0019371)2.39250295
140* cellular lipid catabolic process (GO:0044242)2.39143240
1412-oxoglutarate metabolic process (GO:0006103)2.38799372
142protein heterotrimerization (GO:0070208)2.38366510
143negative regulation of erythrocyte differentiation (GO:0045647)2.33773906
144negative regulation of lipid storage (GO:0010888)2.32440942
145glycolipid catabolic process (GO:0019377)2.30834754
146regulation of platelet activation (GO:0010543)2.28183862
147platelet aggregation (GO:0070527)2.28124431
148platelet degranulation (GO:0002576)2.27454820
149regulation of vitamin metabolic process (GO:0030656)2.25866289
150transcytosis (GO:0045056)2.24309609
151negative regulation of smooth muscle cell proliferation (GO:0048662)2.23225175
152negative regulation of focal adhesion assembly (GO:0051895)2.22568870
153negative regulation of cell junction assembly (GO:1901889)2.22568870
154negative regulation of adherens junction organization (GO:1903392)2.22568870
155synaptic vesicle docking involved in exocytosis (GO:0016081)2.22142955
156response to thyroid hormone (GO:0097066)2.19615411
157membrane raft organization (GO:0031579)2.16106795
158angiotensin maturation (GO:0002003)2.14213917
159regulation of cholesterol transport (GO:0032374)2.13693776
160regulation of sterol transport (GO:0032371)2.13693776
161diacylglycerol metabolic process (GO:0046339)2.13439150
162positive regulation of cholesterol transport (GO:0032376)2.13295984
163positive regulation of sterol transport (GO:0032373)2.13295984
164regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.13137926
165positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.12664329
166negative regulation of amino acid transport (GO:0051956)2.09921177
167renal filtration (GO:0097205)2.08174468
168negative regulation of protein localization to plasma membrane (GO:1903077)2.08168154
169positive regulation of lipid storage (GO:0010884)2.06736945
170glomerular filtration (GO:0003094)2.06479947
171regulation of cholesterol efflux (GO:0010874)2.05648242
172activation of MAPKKK activity (GO:0000185)2.05260001
173regulation of integrin activation (GO:0033623)2.04472735
174endothelium development (GO:0003158)2.03820270
175fat-soluble vitamin biosynthetic process (GO:0042362)2.03788028
176negative regulation of hemostasis (GO:1900047)2.00147169
177negative regulation of blood coagulation (GO:0030195)2.00147169
178regulation of vitamin D biosynthetic process (GO:0060556)1.99429603
179cortical actin cytoskeleton organization (GO:0030866)1.97474979
180actin filament capping (GO:0051693)1.97007087
181cellular response to nutrient (GO:0031670)1.96565784
182fibrinolysis (GO:0042730)1.95776329
183endocytic recycling (GO:0032456)1.95234356
184negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)1.95031728
185regulation of homotypic cell-cell adhesion (GO:0034110)1.94586066
186negative regulation of coagulation (GO:0050819)1.93699631
187regulation of macrophage cytokine production (GO:0010935)1.93069999
188positive regulation of blood coagulation (GO:0030194)1.93023458
189positive regulation of hemostasis (GO:1900048)1.93023458
190keratan sulfate catabolic process (GO:0042340)1.92309833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.67116413
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.16111053
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.09027029
4* LXR_22158963_ChIP-Seq_LIVER_Mouse2.79519599
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.46557195
6* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.38613343
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17878763
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.17869883
9* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.11168871
10LXR_22292898_ChIP-Seq_THP-1_Human2.10405069
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06419332
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04910056
13EZH2_22144423_ChIP-Seq_EOC_Human1.99166964
14* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92869741
15GBX2_23144817_ChIP-Seq_PC3_Human1.92519262
16* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.90294119
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.83553246
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.81129133
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78594419
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.77103964
21* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76986229
22* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76986229
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76361965
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74231756
25* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73107114
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72104782
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71927181
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67414359
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66795298
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65194811
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63007875
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62630728
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.62113653
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61780881
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60972351
36CLOCK_20551151_ChIP-Seq_293T_Human1.53871953
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.53237539
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52185881
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.50218727
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48876641
41* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47962821
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47679184
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44474946
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44338288
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42292946
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40321947
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38235251
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37886183
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.37449386
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.35313700
51* DROSHA_22980978_ChIP-Seq_HELA_Human1.34642971
52RACK7_27058665_Chip-Seq_MCF-7_Human1.34586366
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34089311
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.34067457
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.33726490
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33475206
57AR_21572438_ChIP-Seq_LNCaP_Human1.32877863
58* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32775079
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.32612855
60TAF15_26573619_Chip-Seq_HEK293_Human1.29201110
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.29116331
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29025135
63KDM2B_26808549_Chip-Seq_K562_Human1.28117822
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26904589
65* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.26067288
66ZNF263_19887448_ChIP-Seq_K562_Human1.26003642
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.24030599
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.23485349
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.22210535
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21915943
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21752581
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21752581
73VDR_24763502_ChIP-Seq_THP-1_Human1.21686263
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.21018610
75* SOX2_20726797_ChIP-Seq_SW620_Human1.18389070
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.14969682
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13972434
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.13698600
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.13472003
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12833544
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.12578220
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12500638
83FOXA2_19822575_ChIP-Seq_HepG2_Human1.09629616
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08712822
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08321535
86KDM2B_26808549_Chip-Seq_DND41_Human1.08149506
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08043379
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07877071
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06116664
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06050792
91VDR_21846776_ChIP-Seq_THP-1_Human1.05844666
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05741807
93SPI1_23127762_ChIP-Seq_K562_Human1.05558982
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04942888
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04223221
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03138998
97* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02883270
98TCF7_22412390_ChIP-Seq_EML_Mouse1.02610008
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02468412
100* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02347477
101P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02148894
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01248157
103* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00834836
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00695020
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00476330
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00306343
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00109414
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99738825
109VDR_24787735_ChIP-Seq_THP-1_Human0.99251478
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99138989
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98404173
112RUNX1_22412390_ChIP-Seq_EML_Mouse0.97734353
113SCL_19346495_ChIP-Seq_HPC-7_Human0.97682712
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97528226
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97344460
116* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97336074
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97019842
118HTT_18923047_ChIP-ChIP_STHdh_Human0.96280471
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96106595
120BCAT_22108803_ChIP-Seq_LS180_Human0.95587349
121SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95242853
122CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95162989
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94710601
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94470243
125* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94307771
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94258667
127SMC4_20622854_ChIP-Seq_HELA_Human0.94200839
128TET1_21451524_ChIP-Seq_MESCs_Mouse0.93646121
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93552860
130* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92939860
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91961963
132* FOXO3_23340844_ChIP-Seq_DLD1_Human0.90109963
133CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89192539
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88698266
135REST_21632747_ChIP-Seq_MESCs_Mouse0.87690330
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87679616
137RXR_22108803_ChIP-Seq_LS180_Human0.86728070
138RARB_27405468_Chip-Seq_BRAIN_Mouse0.86458343
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.86393563
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85914361
141AHR_22903824_ChIP-Seq_MCF-7_Human0.85678492
142TBX20_22328084_ChIP-Seq_HEART_Mouse0.84718084
143TBX20_22080862_ChIP-Seq_HEART_Mouse0.84718084
144SMAD4_21799915_ChIP-Seq_A2780_Human0.84114112
145NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82753482
146ER_23166858_ChIP-Seq_MCF-7_Human0.82650494
147GATA1_19941826_ChIP-Seq_K562_Human0.80991791
148* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80957772
149* SOX2_21211035_ChIP-Seq_LN229_Gbm0.80236039
150CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80088607
151* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.79915086
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.78648885
153ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78455957
154* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78264214
155PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77416292
156AR_25329375_ChIP-Seq_VCAP_Human0.77346504
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.76904960
158RARG_19884340_ChIP-ChIP_MEFs_Mouse0.76466514
159P300_19829295_ChIP-Seq_ESCs_Human0.76195173
160AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75875037
161REST_18959480_ChIP-ChIP_MESCs_Mouse0.75756938
162* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74648402
163CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74536262
164* GATA2_21666600_ChIP-Seq_HMVEC_Human0.72913989
165SMAD4_21741376_ChIP-Seq_EPCs_Human0.72064855
166MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.71911547
167TP53_18474530_ChIP-ChIP_U2OS_Human0.71487433
168RING1B_27294783_Chip-Seq_ESCs_Mouse0.70659393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.09869882
2MP0002139_abnormal_hepatobiliary_system3.60621113
3MP0005360_urolithiasis3.16412079
4MP0004130_abnormal_muscle_cell3.13896597
5MP0005666_abnormal_adipose_tissue3.02951048
6MP0005365_abnormal_bile_salt2.89791302
7MP0002837_dystrophic_cardiac_calcinosis2.87736543
8MP0003690_abnormal_glial_cell2.82721347
9MP0005058_abnormal_lysosome_morphology2.76824580
10MP0004185_abnormal_adipocyte_glucose2.75381504
11MP0003303_peritoneal_inflammation2.70012437
12MP0010329_abnormal_lipoprotein_level2.69678044
13MP0005085_abnormal_gallbladder_physiolo2.56016120
14MP0003705_abnormal_hypodermis_morpholog2.41186920
15MP0008875_abnormal_xenobiotic_pharmacok2.32276688
16MP0005464_abnormal_platelet_physiology2.31263800
17MP0005375_adipose_tissue_phenotype2.19020001
18MP0003191_abnormal_cellular_cholesterol2.13531411
19MP0004510_myositis2.11847085
20MP0000920_abnormal_myelination2.11156397
21* MP0002118_abnormal_lipid_homeostasis2.10582463
22MP0000343_altered_response_to2.10160501
23MP0003329_amyloid_beta_deposits2.06289627
24MP0003279_aneurysm2.00635001
25MP0002971_abnormal_brown_adipose1.89490972
26MP0008438_abnormal_cutaneous_collagen1.85396657
27MP0002876_abnormal_thyroid_physiology1.84653545
28MP0003566_abnormal_cell_adhesion1.80199022
29MP0000013_abnormal_adipose_tissue1.79831747
30MP0001958_emphysema1.76760469
31MP0005332_abnormal_amino_acid1.68364902
32MP0003806_abnormal_nucleotide_metabolis1.62074448
33MP0003011_delayed_dark_adaptation1.61473300
34MP0001661_extended_life_span1.59385367
35MP0003828_pulmonary_edema1.59166192
36MP0003879_abnormal_hair_cell1.57538753
37MP0009840_abnormal_foam_cell1.55611996
38MP0003436_decreased_susceptibility_to1.55428449
39MP0003950_abnormal_plasma_membrane1.52799308
40MP0005165_increased_susceptibility_to1.52497004
41MP0003091_abnormal_cell_migration1.51576557
42MP0008004_abnormal_stomach_pH1.50014099
43MP0001533_abnormal_skeleton_physiology1.49967339
44MP0002148_abnormal_hypersensitivity_rea1.49831433
45* MP0005535_abnormal_body_temperature1.46094692
46MP0000604_amyloidosis1.45557152
47MP0005023_abnormal_wound_healing1.44795150
48MP0002998_abnormal_bone_remodeling1.41776165
49MP0006082_CNS_inflammation1.40405045
50MP0004859_abnormal_synaptic_plasticity1.40029727
51MP0000003_abnormal_adipose_tissue1.39987583
52MP0005334_abnormal_fat_pad1.38600499
53MP0005166_decreased_susceptibility_to1.36310062
54MP0000465_gastrointestinal_hemorrhage1.34121321
55MP0009780_abnormal_chondrocyte_physiolo1.33894674
56MP0000751_myopathy1.32808312
57MP0005584_abnormal_enzyme/coenzyme_acti1.32359953
58MP0004270_analgesia1.32052596
59MP0003300_gastrointestinal_ulcer1.30740739
60MP0005164_abnormal_response_to1.30509498
61MP0003252_abnormal_bile_duct1.29722082
62MP0003195_calcinosis1.25935646
63MP0005275_abnormal_skin_tensile1.23607324
64MP0001501_abnormal_sleep_pattern1.22751383
65MP0001542_abnormal_bone_strength1.22188417
66MP0002254_reproductive_system_inflammat1.21815866
67MP0003172_abnormal_lysosome_physiology1.21748649
68MP0003448_altered_tumor_morphology1.21233875
69MP0000858_altered_metastatic_potential1.20823111
70MP0000609_abnormal_liver_physiology1.20065946
71MP0009785_altered_susceptibility_to1.19881213
72MP0001486_abnormal_startle_reflex1.19352666
73MP0002822_catalepsy1.18574189
74MP0004147_increased_porphyrin_level1.18197501
75MP0000249_abnormal_blood_vessel1.18007685
76MP0002419_abnormal_innate_immunity1.15526031
77MP0004947_skin_inflammation1.14705735
78MP0005451_abnormal_body_composition1.14609034
79MP0003880_abnormal_central_pattern1.14365552
80MP0009115_abnormal_fat_cell1.10898219
81MP0004215_abnormal_myocardial_fiber1.10262637
82MP0005083_abnormal_biliary_tract1.10117890
83MP0004036_abnormal_muscle_relaxation1.09771999
84MP0002064_seizures1.09456095
85MP0003453_abnormal_keratinocyte_physiol1.08651559
86MP0002796_impaired_skin_barrier1.07110833
87MP0009046_muscle_twitch1.07050884
88MP0002272_abnormal_nervous_system1.06979120
89MP0001666_abnormal_nutrient_absorption1.06846690
90MP0004272_abnormal_basement_membrane1.05654172
91MP0002090_abnormal_vision1.05284039
92MP0003868_abnormal_feces_composition1.03293846
93MP0006138_congestive_heart_failure1.02655840
94MP0003075_altered_response_to1.02640441
95MP0002877_abnormal_melanocyte_morpholog1.02628460
96MP0005330_cardiomyopathy1.01512913
97MP0005025_abnormal_response_to1.01493172
98MP0005503_abnormal_tendon_morphology1.01107058
99MP0005000_abnormal_immune_tolerance1.00136241
100MP0003633_abnormal_nervous_system0.99333864
101MP0004019_abnormal_vitamin_homeostasis0.98832903
102MP0005257_abnormal_intraocular_pressure0.98698620
103MP0002295_abnormal_pulmonary_circulatio0.97234349
104MP0005620_abnormal_muscle_contractility0.96328692
105* MP0008874_decreased_physiological_sensi0.96260437
106MP0010155_abnormal_intestine_physiology0.96102190
107MP0005623_abnormal_meninges_morphology0.95299809
108MP0003635_abnormal_synaptic_transmissio0.95188878
109MP0005387_immune_system_phenotype0.95073087
110MP0001790_abnormal_immune_system0.95073087
111MP0003634_abnormal_glial_cell0.94863316
112MP0009764_decreased_sensitivity_to0.94852384
113MP0006036_abnormal_mitochondrial_physio0.94134052
114MP0005167_abnormal_blood-brain_barrier0.94092548
115MP0005448_abnormal_energy_balance0.93748912
116MP0004885_abnormal_endolymph0.93474021
117MP0003186_abnormal_redox_activity0.91996508
118MP0005319_abnormal_enzyme/_coenzyme0.91239432
119MP0000767_abnormal_smooth_muscle0.89906169
120MP0001851_eye_inflammation0.89414676
121MP0005390_skeleton_phenotype0.88383365
122MP0003045_fibrosis0.87410154
123MP0002078_abnormal_glucose_homeostasis0.87252061
124MP0003183_abnormal_peptide_metabolism0.87082910
125* MP0009745_abnormal_behavioral_response0.86688639
126MP0000685_abnormal_immune_system0.84862367
127MP0001835_abnormal_antigen_presentation0.83632123
128MP0002896_abnormal_bone_mineralization0.83560951
129MP0003631_nervous_system_phenotype0.83273836
130MP0001545_abnormal_hematopoietic_system0.82994317
131MP0005397_hematopoietic_system_phenotyp0.82994317
132MP0010368_abnormal_lymphatic_system0.82145168
133MP0002972_abnormal_cardiac_muscle0.81759653
134MP0002332_abnormal_exercise_endurance0.80917798
135MP0000230_abnormal_systemic_arterial0.79907945
136MP0000747_muscle_weakness0.79501950
137MP0004883_abnormal_blood_vessel0.78960580
138MP0003959_abnormal_lean_body0.77763000
139MP0009643_abnormal_urine_homeostasis0.76568856
140MP0002970_abnormal_white_adipose0.75704281
141MP0008775_abnormal_heart_ventricle0.75292533
142MP0000749_muscle_degeneration0.74613793
143MP0003646_muscle_fatigue0.74498481
144MP0004087_abnormal_muscle_fiber0.73938936
145MP0005595_abnormal_vascular_smooth0.72310441
146MP0001177_atelectasis0.71743151
147MP0003632_abnormal_nervous_system0.71557432
148MP0005452_abnormal_adipose_tissue0.71337127
149MP0001764_abnormal_homeostasis0.70945773
150MP0004742_abnormal_vestibular_system0.70416977
151MP0005386_behavior/neurological_phenoty0.69751455
152MP0004924_abnormal_behavior0.69751455
153MP0008569_lethality_at_weaning0.69166537
154MP0002063_abnormal_learning/memory/cond0.69126437
155MP0005647_abnormal_sex_gland0.68643723
156MP0001440_abnormal_grooming_behavior0.68264578
157MP0003724_increased_susceptibility_to0.68188462

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.28305463
2Abnormality of liposaccharide metabolism (HP:0010968)4.28305463
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.28305463
4Hyperlipoproteinemia (HP:0010980)4.22929894
5Neurofibrillary tangles (HP:0002185)4.16088654
6Xanthomatosis (HP:0000991)4.06286117
7Hyperglycinuria (HP:0003108)4.05780566
8Abnormality of serine family amino acid metabolism (HP:0010894)3.90456958
9Abnormality of glycine metabolism (HP:0010895)3.90456958
10Purpura (HP:0000979)3.88189888
11Systemic lupus erythematosus (HP:0002725)3.65928918
12Deep venous thrombosis (HP:0002625)3.62497657
13Protrusio acetabuli (HP:0003179)3.56119897
14Petechiae (HP:0000967)3.54168196
15Intrahepatic cholestasis (HP:0001406)3.48718887
16Increased mean platelet volume (HP:0011877)3.47866805
17Ketosis (HP:0001946)3.46619418
18Complement deficiency (HP:0004431)3.33989828
19Dysostosis multiplex (HP:0000943)3.32088276
20Cerebral inclusion bodies (HP:0100314)3.31842025
21Abnormal platelet volume (HP:0011876)3.19429568
22Epidermoid cyst (HP:0200040)3.18715131
23Abnormality of fatty-acid metabolism (HP:0004359)3.14729088
24Acanthosis nigricans (HP:0000956)3.14141286
25Hyperammonemia (HP:0001987)3.12134352
26Hypoalphalipoproteinemia (HP:0003233)3.08479345
27Ketoacidosis (HP:0001993)3.06847931
28Menorrhagia (HP:0000132)3.05839161
29Prolonged bleeding time (HP:0003010)3.05620987
30Abnormality of aromatic amino acid family metabolism (HP:0004338)3.05202116
31Premature rupture of membranes (HP:0001788)2.99664810
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.97171660
33Hyperglycinemia (HP:0002154)2.96224553
34Vertebral compression fractures (HP:0002953)2.93763706
35Oligomenorrhea (HP:0000876)2.88567753
36Hypoglycemic coma (HP:0001325)2.82148078
37Myoglobinuria (HP:0002913)2.79161886
38Hypertriglyceridemia (HP:0002155)2.78418052
39Cerebral hemorrhage (HP:0001342)2.75354234
40Hyporeflexia of lower limbs (HP:0002600)2.70216314
41Degeneration of the lateral corticospinal tracts (HP:0002314)2.69874921
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.69874921
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.68216811
44Sensory axonal neuropathy (HP:0003390)2.63543227
45Aortic aneurysm (HP:0004942)2.61598052
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60401824
47Dicarboxylic aciduria (HP:0003215)2.60401824
48Amyloidosis (HP:0011034)2.57197543
49Prolonged partial thromboplastin time (HP:0003645)2.56031356
50Difficulty running (HP:0009046)2.55586727
51Abnormality of skeletal muscle fiber size (HP:0012084)2.52781656
52Abnormality of polysaccharide metabolism (HP:0011012)2.52773343
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.52773343
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.52773343
55Distal lower limb amyotrophy (HP:0008944)2.52582131
56Mucopolysacchariduria (HP:0008155)2.50650722
57Urinary glycosaminoglycan excretion (HP:0003541)2.50650722
58Intention tremor (HP:0002080)2.48987247
59Exercise-induced myalgia (HP:0003738)2.48499744
60Increased cerebral lipofuscin (HP:0011813)2.46193659
61Nuclear cataract (HP:0100018)2.46176809
62Hypolipoproteinemia (HP:0010981)2.45090624
63Type 1 muscle fiber predominance (HP:0003803)2.44174786
64Spinal rigidity (HP:0003306)2.43483934
65Muscle fiber splitting (HP:0003555)2.42280576
66Abnormality of glycolysis (HP:0004366)2.36703526
67Increased serum pyruvate (HP:0003542)2.36703526
68Epistaxis (HP:0000421)2.35954003
69Distal lower limb muscle weakness (HP:0009053)2.34402003
70Polycythemia (HP:0001901)2.34104151
71Hypercholesterolemia (HP:0003124)2.32875275
72Increased muscle lipid content (HP:0009058)2.31517196
73Mutism (HP:0002300)2.31228891
74Cerebral edema (HP:0002181)2.30357737
75Vacuolated lymphocytes (HP:0001922)2.26784580
76Increased connective tissue (HP:0009025)2.23860566
77Impaired platelet aggregation (HP:0003540)2.22806980
78Abnormal platelet function (HP:0011869)2.22806980
79Skin nodule (HP:0200036)2.20011175
80Asymmetric septal hypertrophy (HP:0001670)2.19328616
81Parakeratosis (HP:0001036)2.17798978
82Hemorrhage of the eye (HP:0011885)2.17225463
83Hyperventilation (HP:0002883)2.15087709
84Abnormality of the Achilles tendon (HP:0005109)2.14760015
85Achilles tendon contracture (HP:0001771)2.11777012
86Abnormality of glutamine family amino acid metabolism (HP:0010902)2.10377323
87Abnormality of complement system (HP:0005339)2.10337117
88Abnormality of the corticospinal tract (HP:0002492)2.09664988
89Insidious onset (HP:0003587)2.09402831
90Termporal pattern (HP:0011008)2.09402831
91Delayed CNS myelination (HP:0002188)2.09371179
92Vascular tortuosity (HP:0004948)2.09123629
93Gingival bleeding (HP:0000225)2.08940006
94Glomerulonephritis (HP:0000099)2.07101558
95Myokymia (HP:0002411)2.05191563
96Lethargy (HP:0001254)2.05047624
97Lower limb amyotrophy (HP:0007210)2.04822033
98Acute encephalopathy (HP:0006846)2.04419936
99Abnormality of monocarboxylic acid metabolism (HP:0010996)2.04077457
100Pheochromocytoma (HP:0002666)2.02791997
101Cerebral aneurysm (HP:0004944)2.02473276
102Loss of speech (HP:0002371)2.02338550
103Hydroxyprolinuria (HP:0003080)2.02170981
104Abnormality of proline metabolism (HP:0010907)2.02170981
105Supranuclear gaze palsy (HP:0000605)2.02102064
106Aortic dissection (HP:0002647)2.01965580
107Interstitial pulmonary disease (HP:0006530)2.00525667
108Mildly elevated creatine phosphokinase (HP:0008180)1.99996121
109Abnormality of macrophages (HP:0004311)1.99011085
110Onion bulb formation (HP:0003383)1.98592461
111Hepatosplenomegaly (HP:0001433)1.98184732
112Hypobetalipoproteinemia (HP:0003563)1.97087812
113Methylmalonic acidemia (HP:0002912)1.96710718
114Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96282552
115Increased neuronal autofluorescent lipopigment (HP:0002074)1.96171990
116Ankle contracture (HP:0006466)1.96132610
117Bone cyst (HP:0012062)1.94935507
118Abnormal gallbladder morphology (HP:0012437)1.94631588
119Vomiting (HP:0002013)1.94034488
120Cervical subluxation (HP:0003308)1.93350293
121Distal upper limb amyotrophy (HP:0007149)1.92570461
122Upper limb amyotrophy (HP:0009129)1.92570461
123Dysmetria (HP:0001310)1.92303311
124Emphysema (HP:0002097)1.91048335
125Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90497431
126Metabolic acidosis (HP:0001942)1.89582710
127Action tremor (HP:0002345)1.88109692
128Sudden death (HP:0001699)1.88052876
129Axonal loss (HP:0003447)1.86443002
130Increased variability in muscle fiber diameter (HP:0003557)1.85746659
131Wormian bones (HP:0002645)1.85026967
132Spastic paraparesis (HP:0002313)1.84271922
133Osteolytic defects of the hand bones (HP:0009699)1.83779810
134Osteolytic defects of the phalanges of the hand (HP:0009771)1.83779810
135Hepatic necrosis (HP:0002605)1.83451608
136Cholelithiasis (HP:0001081)1.83297932
137Hyperparathyroidism (HP:0000843)1.81894395
138Polygenic inheritance (HP:0010982)1.81290370
139Pancreatitis (HP:0001733)1.81060571
140Joint stiffness (HP:0001387)1.80619277
141Brushfield spots (HP:0001088)1.80601777
142Rhabdomyolysis (HP:0003201)1.80515189
143Muscle hypertrophy of the lower extremities (HP:0008968)1.80513417
144Abnormal eating behavior (HP:0100738)1.79903728
145Abnormal gallbladder physiology (HP:0012438)1.79362784
146Cholecystitis (HP:0001082)1.79362784
147Focal motor seizures (HP:0011153)1.78591128
148Abnormality of the nasal mucosa (HP:0000433)1.78589190
149Slender build (HP:0001533)1.78412694
150Apathy (HP:0000741)1.78074807
151Myocardial infarction (HP:0001658)1.78050761
152Arterial tortuosity (HP:0005116)1.77370953
153Follicular hyperkeratosis (HP:0007502)1.77275687
154Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76646470
155Abnormality of the periventricular white matter (HP:0002518)1.76401910
156Nephritis (HP:0000123)1.76050042
157Joint hemorrhage (HP:0005261)1.75719251
158Sensorimotor neuropathy (HP:0007141)1.74639912
159Abnormality of serum amino acid levels (HP:0003112)1.74486138
160Methylmalonic aciduria (HP:0012120)1.73803898
161Spontaneous hematomas (HP:0007420)1.73380295
162Mitral stenosis (HP:0001718)1.72688516
163Aplasia involving bones of the upper limbs (HP:0009823)1.72042785
164Aplasia of the phalanges of the hand (HP:0009802)1.72042785
165Aplasia involving bones of the extremities (HP:0009825)1.72042785
166Dilatation of the ascending aorta (HP:0005111)1.71522668
167Aneurysm (HP:0002617)1.71473373
168Diminished motivation (HP:0000745)1.70654149
169Craniofacial dystonia (HP:0012179)1.70126141
170Fat malabsorption (HP:0002630)1.70037699
171Abnormality of methionine metabolism (HP:0010901)1.69863823
172Muscle stiffness (HP:0003552)1.68919065
173Malnutrition (HP:0004395)1.67381070
174Neuroendocrine neoplasm (HP:0100634)1.67189646
175Focal segmental glomerulosclerosis (HP:0000097)1.66581708
176Bladder diverticulum (HP:0000015)1.66365974
177Calf muscle hypertrophy (HP:0008981)1.60760797
178Pigmentary retinal degeneration (HP:0001146)1.60465992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.46980284
2BCKDK3.10274623
3IRAK32.66251082
4CAMK1D2.54319346
5CAMK1G2.45545781
6EPHA42.45200977
7EPHB12.36537054
8TESK12.30205950
9TRIB32.28948866
10RIPK42.25321125
11SIK12.22649342
12OXSR12.20358263
13TGFBR21.98401693
14FGFR21.85908419
15PDGFRA1.85627109
16TIE11.75481511
17WNK41.72699880
18LMTK21.69937005
19PHKG21.67133839
20PHKG11.67133839
21PDK31.66621988
22PDK41.66621988
23TAOK21.65005554
24MST1R1.64836054
25TBK11.64071244
26NTRK11.63725979
27MET1.60663333
28TNIK1.58433374
29MAP3K111.57772032
30PIM21.46322876
31MOS1.45419927
32PDK21.44574354
33PKN11.39340340
34CDC42BPA1.37261199
35MAP3K31.37065545
36LIMK11.35185310
37PINK11.34461943
38LATS21.33322821
39PAK61.32568903
40INSRR1.30271257
41NEK91.29037570
42ICK1.28947553
43TYRO31.26916199
44PDPK11.25791398
45GRK71.24940423
46MAP3K131.20849575
47DAPK21.19023465
48MAP2K31.17436376
49BCR1.17151140
50MYLK1.15150907
51PIK3CA1.13253294
52TYK21.12857491
53NME21.12538252
54PRKD31.12288056
55KSR21.11942271
56PRKAA21.11329190
57PTK21.10122157
58PTK2B1.09908416
59BMX1.07528076
60MAP3K141.07102279
61KIT1.05008076
62MAP2K41.02777906
63EPHA21.02433674
64PRPF4B1.01412754
65ZAP701.00937920
66DAPK31.00264888
67PAK30.99514535
68MAPKAPK30.99106426
69JAK10.98965014
70WNK10.96246552
71SGK4940.95467961
72SGK2230.95467961
73PBK0.93166808
74MAPKAPK50.90698807
75PAK20.89734476
76PRKG20.89513112
77PDK10.87650798
78FGR0.87489709
79MAPK40.85794822
80MAP3K10.85019662
81CDK50.84854544
82ERBB40.84842581
83CASK0.84723070
84PRKD10.84198087
85TESK20.83294835
86MAP3K20.82489322
87MAPK120.81119817
88OBSCN0.80408907
89RIPK10.77855228
90BMPR20.76235944
91FGFR40.76086558
92MAP2K10.75963274
93ROCK20.75383547
94PRKD20.73818041
95PRKCH0.73054664
96NTRK30.72929327
97RET0.71498972
98TAOK10.71481410
99NTRK20.71473639
100FES0.70890708
101GRK50.70627987
102PAK40.70588544
103NEK60.70235982
104CAMKK10.69596820
105CAMK2D0.69295751
106CAMK2G0.69253529
107MATK0.68302885
108PRKCE0.68241678
109BLK0.67756736
110CAMK2A0.67645986
111TTN0.66896780
112MARK20.66817048
113FER0.66481838
114PRKCQ0.65374877
115ILK0.63547331
116ABL20.63472276
117MAPK70.63293204
118DMPK0.63178072
119MAP3K40.63167999
120CAMK10.62247397
121TRPM70.61620718
122IRAK20.61274396
123EPHB20.60711397
124JAK30.59513964
125RPS6KA20.59245185
126CAMK2B0.58754003
127PRKACG0.58648338
128PDGFRB0.58014402
129CAMKK20.57407497
130DDR20.56409316
131ERN10.56200183
132IKBKB0.55881717
133GSK3A0.55112872
134MAP3K90.54629325
135STK380.54315589
136MAP3K70.54125644
137CSF1R0.54057728
138FYN0.53696100
139MUSK0.50222295
140CSNK1G20.49493095
141IKBKE0.49374207
142MINK10.47912498
143JAK20.47765362
144ROCK10.47743503
145ARAF0.47671072
146CSK0.47309209
147STK110.47283014
148DAPK10.46935139
149SYK0.46272258
150PRKAA10.46199458
151CSNK1G10.45394036
152PIK3CG0.44702307
153IRAK10.44510013
154PAK10.44458992

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.06360052
2Nitrogen metabolism_Homo sapiens_hsa009102.98600078
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82124622
4Fatty acid metabolism_Homo sapiens_hsa012122.76771324
5PPAR signaling pathway_Homo sapiens_hsa033202.69035664
6Fatty acid degradation_Homo sapiens_hsa000712.66270972
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61423794
8Fatty acid elongation_Homo sapiens_hsa000622.57566597
9Butanoate metabolism_Homo sapiens_hsa006502.54627569
10Fatty acid biosynthesis_Homo sapiens_hsa000612.48457946
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46803863
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.34576939
13Other glycan degradation_Homo sapiens_hsa005112.31831622
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96733350
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.90126759
16Peroxisome_Homo sapiens_hsa041461.80351730
17Lysosome_Homo sapiens_hsa041421.76820886
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76548363
19beta-Alanine metabolism_Homo sapiens_hsa004101.75131720
20Steroid biosynthesis_Homo sapiens_hsa001001.70271147
21Pyruvate metabolism_Homo sapiens_hsa006201.70005853
22Arginine biosynthesis_Homo sapiens_hsa002201.65873351
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60071219
24Tryptophan metabolism_Homo sapiens_hsa003801.57457567
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53804850
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52977715
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47962928
28* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.45530056
29Sulfur metabolism_Homo sapiens_hsa009201.39665723
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36488094
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36108120
32Pertussis_Homo sapiens_hsa051331.34128777
33* Glycerolipid metabolism_Homo sapiens_hsa005611.33558978
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30339703
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28079167
36Complement and coagulation cascades_Homo sapiens_hsa046101.25993921
37Platelet activation_Homo sapiens_hsa046111.23974699
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23448956
39Fat digestion and absorption_Homo sapiens_hsa049751.20787537
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18477291
41Histidine metabolism_Homo sapiens_hsa003401.18363305
42Tyrosine metabolism_Homo sapiens_hsa003501.18093242
43Osteoclast differentiation_Homo sapiens_hsa043801.15297725
44Rheumatoid arthritis_Homo sapiens_hsa053231.14406475
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13863917
46Malaria_Homo sapiens_hsa051441.13475133
47Amoebiasis_Homo sapiens_hsa051461.13347326
48Phenylalanine metabolism_Homo sapiens_hsa003601.11166397
49Carbon metabolism_Homo sapiens_hsa012001.10835228
50Vitamin B6 metabolism_Homo sapiens_hsa007501.09213793
51Caffeine metabolism_Homo sapiens_hsa002321.08824296
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06725944
53Focal adhesion_Homo sapiens_hsa045101.04495567
54Bile secretion_Homo sapiens_hsa049761.04388738
55Chemical carcinogenesis_Homo sapiens_hsa052041.02720555
56Leishmaniasis_Homo sapiens_hsa051401.00913670
57TNF signaling pathway_Homo sapiens_hsa046680.97767969
58Asthma_Homo sapiens_hsa053100.96304202
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95790637
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.95307623
61Retinol metabolism_Homo sapiens_hsa008300.94653919
62Salmonella infection_Homo sapiens_hsa051320.94374902
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93841563
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92578500
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.91847347
66Allograft rejection_Homo sapiens_hsa053300.91706505
67Oxidative phosphorylation_Homo sapiens_hsa001900.88932597
68Phagosome_Homo sapiens_hsa041450.88681813
69Renin-angiotensin system_Homo sapiens_hsa046140.88592127
70Toxoplasmosis_Homo sapiens_hsa051450.86667695
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86461976
72Tuberculosis_Homo sapiens_hsa051520.85405992
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.84854692
74ABC transporters_Homo sapiens_hsa020100.84078725
75Staphylococcus aureus infection_Homo sapiens_hsa051500.83665268
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82620125
77Mineral absorption_Homo sapiens_hsa049780.81240544
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80214639
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79135857
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79048439
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.78378555
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.78374051
83African trypanosomiasis_Homo sapiens_hsa051430.77668947
84Ether lipid metabolism_Homo sapiens_hsa005650.77593440
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75609177
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72135252
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.71312571
88Fructose and mannose metabolism_Homo sapiens_hsa000510.70753135
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70426822
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68845976
91GnRH signaling pathway_Homo sapiens_hsa049120.68799776
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67809460
93Galactose metabolism_Homo sapiens_hsa000520.67702810
94Graft-versus-host disease_Homo sapiens_hsa053320.66881724
95Arginine and proline metabolism_Homo sapiens_hsa003300.65477625
96Hepatitis C_Homo sapiens_hsa051600.64818909
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64244488
98Hematopoietic cell lineage_Homo sapiens_hsa046400.63927684
99Endocytosis_Homo sapiens_hsa041440.63538900
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.62691521
101Alzheimers disease_Homo sapiens_hsa050100.62550258
102Linoleic acid metabolism_Homo sapiens_hsa005910.62243004
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61803833
104Vibrio cholerae infection_Homo sapiens_hsa051100.61714430
105Starch and sucrose metabolism_Homo sapiens_hsa005000.61242944
106AMPK signaling pathway_Homo sapiens_hsa041520.61137292
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60700627
108Long-term potentiation_Homo sapiens_hsa047200.60431468
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58613327
110Autoimmune thyroid disease_Homo sapiens_hsa053200.58057696
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57737470
112GABAergic synapse_Homo sapiens_hsa047270.57687672
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57500399
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57282716
115Chemokine signaling pathway_Homo sapiens_hsa040620.57040009
116Renin secretion_Homo sapiens_hsa049240.55430907
117Parkinsons disease_Homo sapiens_hsa050120.54680025
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54660601
119Viral myocarditis_Homo sapiens_hsa054160.54179768
120Cardiac muscle contraction_Homo sapiens_hsa042600.53145053
121Sphingolipid metabolism_Homo sapiens_hsa006000.52310084
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51831670
123Salivary secretion_Homo sapiens_hsa049700.50000818
124Protein digestion and absorption_Homo sapiens_hsa049740.49390613
125Biosynthesis of amino acids_Homo sapiens_hsa012300.49272279
126Shigellosis_Homo sapiens_hsa051310.48738040
127VEGF signaling pathway_Homo sapiens_hsa043700.48133541
128B cell receptor signaling pathway_Homo sapiens_hsa046620.48060924
129Influenza A_Homo sapiens_hsa051640.47734739
130Glutamatergic synapse_Homo sapiens_hsa047240.46053945
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42464859
132Insulin resistance_Homo sapiens_hsa049310.42136118
133Glutathione metabolism_Homo sapiens_hsa004800.39668895
134Gastric acid secretion_Homo sapiens_hsa049710.37680806
135* Metabolic pathways_Homo sapiens_hsa011000.36279745
136Sulfur relay system_Homo sapiens_hsa041220.36255366
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.36059668
138Morphine addiction_Homo sapiens_hsa050320.33508090
139Glucagon signaling pathway_Homo sapiens_hsa049220.32822958
140Collecting duct acid secretion_Homo sapiens_hsa049660.32688163
141Pentose phosphate pathway_Homo sapiens_hsa000300.32489890
142Vitamin digestion and absorption_Homo sapiens_hsa049770.31676922
143* Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30988292
144Axon guidance_Homo sapiens_hsa043600.30540396
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30339265
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30335024
147Ovarian steroidogenesis_Homo sapiens_hsa049130.29710582
148Prion diseases_Homo sapiens_hsa050200.28936702
149Circadian entrainment_Homo sapiens_hsa047130.28579282
150Cysteine and methionine metabolism_Homo sapiens_hsa002700.28390224
151cAMP signaling pathway_Homo sapiens_hsa040240.27573086
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27000163
153ECM-receptor interaction_Homo sapiens_hsa045120.23813189
154Insulin signaling pathway_Homo sapiens_hsa049100.22434736
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.21877520
156Dilated cardiomyopathy_Homo sapiens_hsa054140.20540844
157Calcium signaling pathway_Homo sapiens_hsa040200.20400165
158Synaptic vesicle cycle_Homo sapiens_hsa047210.19833790
159Dorso-ventral axis formation_Homo sapiens_hsa043200.19089820
160Cholinergic synapse_Homo sapiens_hsa047250.18896147
161cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18656452
162Type II diabetes mellitus_Homo sapiens_hsa049300.18545200

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