MGP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1white fat cell differentiation (GO:0050872)5.40972769
2collagen fibril organization (GO:0030199)5.39245947
3protein heterotrimerization (GO:0070208)4.82117779
4keratan sulfate catabolic process (GO:0042340)4.67877094
5endocrine hormone secretion (GO:0060986)4.62661928
6peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.53262013
7blood vessel maturation (GO:0001955)4.39249860
8chondrocyte proliferation (GO:0035988)4.31472656
9sequestering of extracellular ligand from receptor (GO:0035581)4.20243437
10desmosome organization (GO:0002934)4.19830113
11cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.02970382
12basement membrane organization (GO:0071711)3.96362043
13collagen metabolic process (GO:0032963)3.93417365
14lymph vessel development (GO:0001945)3.92703801
15vascular endothelial growth factor signaling pathway (GO:0038084)3.91519578
16collagen catabolic process (GO:0030574)3.88191267
17extracellular matrix assembly (GO:0085029)3.83157742
18retina vasculature morphogenesis in camera-type eye (GO:0061299)3.80187338
19myelination in peripheral nervous system (GO:0022011)3.77051873
20peripheral nervous system axon ensheathment (GO:0032292)3.77051873
21multicellular organismal macromolecule metabolic process (GO:0044259)3.76890182
22positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.71362365
23endothelial cell morphogenesis (GO:0001886)3.71294740
24multicellular organismal catabolic process (GO:0044243)3.65253853
25surfactant homeostasis (GO:0043129)3.63892389
26extracellular fibril organization (GO:0043206)3.63886044
27iron ion import (GO:0097286)3.59178732
28endodermal cell differentiation (GO:0035987)3.58430603
29multicellular organismal metabolic process (GO:0044236)3.57415722
30glomerular filtration (GO:0003094)3.55991032
31lymphangiogenesis (GO:0001946)3.54519971
32mammary gland epithelial cell differentiation (GO:0060644)3.53957549
33glomerular basement membrane development (GO:0032836)3.52100564
34bundle of His cell to Purkinje myocyte communication (GO:0086069)3.51371591
35negative regulation of complement activation (GO:0045916)3.49226573
36cell adhesion mediated by integrin (GO:0033627)3.47892194
37bone trabecula formation (GO:0060346)3.45858975
38dermatan sulfate biosynthetic process (GO:0030208)3.43515570
39renal filtration (GO:0097205)3.42991802
40keratinocyte development (GO:0003334)3.42814766
41regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.40049886
42skin morphogenesis (GO:0043589)3.37143289
43neuron projection extension involved in neuron projection guidance (GO:1902284)3.34730583
44axon extension involved in axon guidance (GO:0048846)3.34730583
45endothelial cell chemotaxis (GO:0035767)3.32825391
46negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.32761353
47angiogenesis involved in wound healing (GO:0060055)3.31945683
48extracellular matrix disassembly (GO:0022617)3.31854074
49regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.29082626
50endothelium development (GO:0003158)3.28492237
51plasma membrane repair (GO:0001778)3.27452639
52prostate gland growth (GO:0060736)3.27448719
53positive regulation of p38MAPK cascade (GO:1900745)3.27362983
54dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.27228798
55regulation of endothelial cell differentiation (GO:0045601)3.20200565
56regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.17911264
57dermatan sulfate metabolic process (GO:0030205)3.12636426
58growth hormone receptor signaling pathway (GO:0060396)3.11813702
59smooth muscle tissue development (GO:0048745)3.10329699
60camera-type eye morphogenesis (GO:0048593)3.08984984
61prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.08683758
62insulin-like growth factor receptor signaling pathway (GO:0048009)3.07992537
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.07921594
64negative regulation of cell-matrix adhesion (GO:0001953)3.07731104
65Golgi transport vesicle coating (GO:0048200)3.07306489
66COPI coating of Golgi vesicle (GO:0048205)3.07306489
67fibril organization (GO:0097435)3.06400996
68blood vessel remodeling (GO:0001974)3.04190696
69cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.04184943
70lung secretory cell differentiation (GO:0061140)3.03466800
71regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.02308171
72metanephric mesenchyme development (GO:0072075)3.00908367
73chondrocyte development (GO:0002063)2.99567281
74positive regulation of endothelial cell differentiation (GO:0045603)2.97731290
75lung vasculature development (GO:0060426)2.97475355
76extracellular matrix organization (GO:0030198)2.96925425
77trabecula formation (GO:0060343)2.96771488
78extracellular structure organization (GO:0043062)2.96001481
79negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.94647395
80negative regulation of cardiac muscle tissue growth (GO:0055022)2.92073044
81negative regulation of heart growth (GO:0061117)2.92073044
82negative regulation of chondrocyte differentiation (GO:0032331)2.91293843
83kidney mesenchyme development (GO:0072074)2.90404781
84cardiac myofibril assembly (GO:0055003)2.88899710
85fibroblast migration (GO:0010761)2.88507997
86regulation of p38MAPK cascade (GO:1900744)2.86872042
87opsonization (GO:0008228)2.86858327
88heart trabecula formation (GO:0060347)2.85810342
89adhesion of symbiont to host cell (GO:0044650)2.84222570
90virion attachment to host cell (GO:0019062)2.84222570
91endocardial cushion morphogenesis (GO:0003203)2.83342629
92vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.82822505
93endothelial cell proliferation (GO:0001935)2.82552583
94regulation of histone deacetylation (GO:0031063)2.81520825
95lung lobe morphogenesis (GO:0060463)2.80594808
96cardiac right ventricle morphogenesis (GO:0003215)2.80583884
97detection of molecule of bacterial origin (GO:0032490)2.78814886
98positive regulation of cartilage development (GO:0061036)2.78687751
99regulation of cytokine production involved in inflammatory response (GO:1900015)2.78177498
100chemical homeostasis within a tissue (GO:0048875)2.78101267
101pathway-restricted SMAD protein phosphorylation (GO:0060389)2.77536871
102cellular response to growth hormone stimulus (GO:0071378)2.76855232
103regulation of integrin-mediated signaling pathway (GO:2001044)2.75871734
104protein localization to cell surface (GO:0034394)2.75058200
105regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.73034458
106atrioventricular valve morphogenesis (GO:0003181)2.72837060
107negative regulation of protein activation cascade (GO:2000258)2.71227295
108apoptotic cell clearance (GO:0043277)2.68747050
109epithelial cell-cell adhesion (GO:0090136)2.67742240
110wound healing, spreading of epidermal cells (GO:0035313)2.67615089
111negative regulation of cartilage development (GO:0061037)2.67604328
112negative regulation of leukocyte chemotaxis (GO:0002689)2.67243530
113morphogenesis of an endothelium (GO:0003159)2.66308462
114endothelial tube morphogenesis (GO:0061154)2.66308462
115photoreceptor cell differentiation (GO:0046530)2.66257012
116eye photoreceptor cell differentiation (GO:0001754)2.66257012
117regulation of vasculogenesis (GO:2001212)2.65280088
118mesodermal cell differentiation (GO:0048333)2.64273588
119ovulation from ovarian follicle (GO:0001542)2.64158680
120purine nucleotide transport (GO:0015865)2.63824379
121regulation of water loss via skin (GO:0033561)2.63725852
122ovulation (GO:0030728)2.63474474
123stress fiber assembly (GO:0043149)2.63144444
124keratan sulfate biosynthetic process (GO:0018146)2.62257616
125positive regulation of chondrocyte differentiation (GO:0032332)2.62217326
126protein retention in ER lumen (GO:0006621)2.61026584
127positive regulation of respiratory burst (GO:0060267)2.60298858
128cell migration involved in heart development (GO:0060973)2.59724759
129cardiac muscle cell proliferation (GO:0060038)2.58268412
130cell migration involved in sprouting angiogenesis (GO:0002042)2.58251168
131regulation of chondrocyte differentiation (GO:0032330)2.57254957
132substrate-dependent cell migration (GO:0006929)2.57048197
133cytoskeletal anchoring at plasma membrane (GO:0007016)2.55798768
134adhesion of symbiont to host (GO:0044406)2.54751671
135positive regulation of osteoblast proliferation (GO:0033690)2.54083251
136glutathione biosynthetic process (GO:0006750)2.52415840
137positive regulation of blood vessel endothelial cell migration (GO:0043536)2.51405656
138embryo implantation (GO:0007566)2.50885956
139negative regulation of cell-substrate adhesion (GO:0010812)2.50087685
140sulfur compound catabolic process (GO:0044273)2.49910882
141negative regulation of adherens junction organization (GO:1903392)2.49117986
142negative regulation of focal adhesion assembly (GO:0051895)2.49117986
143negative regulation of cell junction assembly (GO:1901889)2.49117986
144maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49069256
145regulation of macrophage cytokine production (GO:0010935)2.48902824
146nonribosomal peptide biosynthetic process (GO:0019184)2.48712120
147positive regulation of odontogenesis (GO:0042482)2.47977698
148face development (GO:0060324)2.47145157
149positive regulation of endothelial cell apoptotic process (GO:2000353)2.46962374
150mesenchyme morphogenesis (GO:0072132)2.46716729
151NLS-bearing protein import into nucleus (GO:0006607)2.45599433
152embryonic cranial skeleton morphogenesis (GO:0048701)2.44305981
153regulation of lipoprotein metabolic process (GO:0050746)2.43310256
154peripheral nervous system development (GO:0007422)2.41833492
155regulation of cardioblast differentiation (GO:0051890)2.41204012
156glycosaminoglycan catabolic process (GO:0006027)2.39384312
157astrocyte development (GO:0014002)2.39047853
158calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.38920924
159positive regulation of receptor recycling (GO:0001921)2.38078182
160branching involved in mammary gland duct morphogenesis (GO:0060444)2.37886949
161multicellular organismal water homeostasis (GO:0050891)2.36122052
162keratan sulfate metabolic process (GO:0042339)2.35671879
163complement activation, classical pathway (GO:0006958)2.33742156
164mesenchymal-epithelial cell signaling (GO:0060638)2.32946777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.34052600
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.00755851
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.18480657
4CLOCK_20551151_ChIP-Seq_293T_Human3.10924438
5ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.83438186
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.57303304
7ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.56763132
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.52415423
9* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.52311971
10CJUN_26792858_Chip-Seq_BT549_Human2.46052923
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.43171049
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.21686064
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.20763299
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.18064585
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07747868
16CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.07589088
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.06542760
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.05758356
19* GATA2_21666600_ChIP-Seq_HMVEC_Human1.95058070
20* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.93021400
21RACK7_27058665_Chip-Seq_MCF-7_Human1.89929635
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88853040
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.87047210
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86632737
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.86484737
26CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.84085905
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.83215629
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82499653
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.80143604
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.76347436
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.76347436
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.74197407
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72788381
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.71376330
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70576815
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70576815
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.62869209
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.62869209
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.60661992
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59923258
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58262733
42* GATA3_24758297_ChIP-Seq_MCF-7_Human1.58099907
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56748469
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55651021
45TP53_18474530_ChIP-ChIP_U2OS_Human1.53016813
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.50616468
47SOX2_20726797_ChIP-Seq_SW620_Human1.49980675
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.49758741
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.47897846
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.47730860
51* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47434171
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46735837
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44548860
54BRD4_25478319_ChIP-Seq_HGPS_Human1.41634516
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40267772
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37236011
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33986917
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32890398
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31566480
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.30903484
61* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29727667
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29012606
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.28762457
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28203686
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26694566
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26635837
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26225535
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25948064
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25850190
70AR_21572438_ChIP-Seq_LNCaP_Human1.25454282
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24300452
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24300452
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23250909
74ELF5_23300383_ChIP-Seq_T47D_Human1.22477377
75SMC1_22415368_ChIP-Seq_MEFs_Mouse1.21412727
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.19994217
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19004925
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18882418
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17973822
80PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.17552396
81TP53_16413492_ChIP-PET_HCT116_Human1.15574368
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.14255870
83AHR_22903824_ChIP-Seq_MCF-7_Human1.13336870
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11832207
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.11512501
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11275167
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10842888
88MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08030277
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07773249
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07152358
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05903700
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.04701964
93ZNF263_19887448_ChIP-Seq_K562_Human1.04427713
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04143131
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03430705
96UBF1/2_26484160_Chip-Seq_HMECs_Human1.03117073
97CDX2_20551321_ChIP-Seq_CACO-2_Human1.00652361
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00614893
99NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99354640
100BCAT_22108803_ChIP-Seq_LS180_Human0.99335222
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99112020
102WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98194276
103ARNT_22903824_ChIP-Seq_MCF-7_Human0.97705311
104ISL1_27105846_Chip-Seq_CPCs_Mouse0.97268708
105LXR_22292898_ChIP-Seq_THP-1_Human0.94602009
106JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94300953
107NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93548772
108RNF2_27304074_Chip-Seq_ESCs_Mouse0.93398738
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93308566
110KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92612245
111* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91043426
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90845477
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90298710
114SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89805368
115ERG_21242973_ChIP-ChIP_JURKAT_Human0.89384274
116FOXA2_19822575_ChIP-Seq_HepG2_Human0.89271873
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88858374
118GATA1_22025678_ChIP-Seq_K562_Human0.88656148
119GATA4_25053715_ChIP-Seq_YYC3_Human0.87884538
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87805455
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87664378
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86441032
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85626664
124KDM2B_26808549_Chip-Seq_K562_Human0.85618422
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85120268
126DROSHA_22980978_ChIP-Seq_HELA_Human0.85036106
127GATA6_25053715_ChIP-Seq_YYC3_Human0.84995015
128GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84609204
129* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84415306
130EZH2_27294783_Chip-Seq_ESCs_Mouse0.83630397
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83316942
132KLF5_25053715_ChIP-Seq_YYC3_Human0.81200075
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78616169
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77780017
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.75794069
136TP53_23651856_ChIP-Seq_MEFs_Mouse0.74697083
137PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.72044525
138MYC_27129775_Chip-Seq_CORNEA_Mouse0.69986790

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.43942295
2MP0005503_abnormal_tendon_morphology5.21038813
3MP0005275_abnormal_skin_tensile4.85925746
4MP0001958_emphysema4.43542399
5MP0010368_abnormal_lymphatic_system3.24942324
6MP0004272_abnormal_basement_membrane3.23586207
7* MP0003279_aneurysm2.85091369
8MP0003011_delayed_dark_adaptation2.72445547
9MP0001879_abnormal_lymphatic_vessel2.61743449
10MP0006054_spinal_hemorrhage2.54293586
11MP0003705_abnormal_hypodermis_morpholog2.52836876
12MP0002837_dystrophic_cardiac_calcinosis2.42058347
13MP0005670_abnormal_white_adipose2.40540135
14MP0005171_absent_coat_pigmentation2.39228769
15MP0005623_abnormal_meninges_morphology2.33825917
16MP0009384_cardiac_valve_regurgitation2.25878707
17MP0009780_abnormal_chondrocyte_physiolo2.18291756
18MP0004084_abnormal_cardiac_muscle2.16902067
19MP0010234_abnormal_vibrissa_follicle2.15407727
20MP0000751_myopathy2.12309089
21MP0005508_abnormal_skeleton_morphology2.06131923
22MP0003566_abnormal_cell_adhesion1.99871492
23MP0002295_abnormal_pulmonary_circulatio1.97614270
24MP0001542_abnormal_bone_strength1.86491804
25MP0004381_abnormal_hair_follicle1.86155375
26MP0005408_hypopigmentation1.81645084
27MP0003183_abnormal_peptide_metabolism1.80497145
28MP0005248_abnormal_Harderian_gland1.79899306
29MP0002108_abnormal_muscle_morphology1.75871686
30* MP0000767_abnormal_smooth_muscle1.74607073
31MP0001346_abnormal_lacrimal_gland1.73340785
32MP0005646_abnormal_pituitary_gland1.69162856
33MP0002098_abnormal_vibrissa_morphology1.62213118
34MP0005023_abnormal_wound_healing1.62053223
35MP0008995_early_reproductive_senescence1.61554209
36MP0004264_abnormal_extraembryonic_tissu1.58949192
37MP0004036_abnormal_muscle_relaxation1.57494390
38MP0002933_joint_inflammation1.54273783
39MP0009250_abnormal_appendicular_skeleto1.54014786
40MP0000427_abnormal_hair_cycle1.51355960
41MP0004883_abnormal_blood_vessel1.51062764
42MP0005164_abnormal_response_to1.48347572
43MP0002009_preneoplasia1.46643775
44MP0002060_abnormal_skin_morphology1.42461689
45MP0006138_congestive_heart_failure1.38465941
46MP0003091_abnormal_cell_migration1.37522648
47MP0000749_muscle_degeneration1.36564639
48MP0004782_abnormal_surfactant_physiolog1.35919928
49MP0001881_abnormal_mammary_gland1.34089096
50MP0000566_synostosis1.33860442
51MP0004484_altered_response_of1.32915618
52MP0005330_cardiomyopathy1.32836282
53MP0005257_abnormal_intraocular_pressure1.32811841
54MP0000343_altered_response_to1.31805677
55MP0000534_abnormal_ureter_morphology1.31690641
56MP0003950_abnormal_plasma_membrane1.29981688
57MP0008775_abnormal_heart_ventricle1.27353200
58MP0005388_respiratory_system_phenotype1.26509084
59MP0002133_abnormal_respiratory_system1.26509084
60MP0003828_pulmonary_edema1.25159573
61MP0000627_abnormal_mammary_gland1.24871439
62MP0004134_abnormal_chest_morphology1.24598997
63MP0002896_abnormal_bone_mineralization1.24304772
64MP0001661_extended_life_span1.23029727
65MP0000377_abnormal_hair_follicle1.21515243
66MP0005390_skeleton_phenotype1.20307390
67MP0005595_abnormal_vascular_smooth1.19092410
68MP0002796_impaired_skin_barrier1.19071689
69MP0003045_fibrosis1.18851592
70MP0000013_abnormal_adipose_tissue1.18530514
71* MP0000163_abnormal_cartilage_morphology1.18204530
72MP0003385_abnormal_body_wall1.16515735
73MP0005385_cardiovascular_system_phenoty1.15957038
74MP0001544_abnormal_cardiovascular_syste1.15957038
75MP0003191_abnormal_cellular_cholesterol1.12643802
76MP0005666_abnormal_adipose_tissue1.11443157
77MP0005367_renal/urinary_system_phenotyp1.09675665
78MP0000516_abnormal_urinary_system1.09675665
79* MP0002282_abnormal_trachea_morphology1.08931424
80MP0002998_abnormal_bone_remodeling1.07415513
81MP0002254_reproductive_system_inflammat1.06732435
82MP0010030_abnormal_orbit_morphology1.06685338
83* MP0002128_abnormal_blood_circulation1.05451503
84MP0000750_abnormal_muscle_regeneration1.05306136
85* MP0002115_abnormal_skeleton_extremities1.04005320
86MP0005620_abnormal_muscle_contractility1.02566612
87MP0002972_abnormal_cardiac_muscle1.02439562
88MP0000249_abnormal_blood_vessel1.00449456
89MP0003448_altered_tumor_morphology0.98263023
90MP0005165_increased_susceptibility_to0.97451395
91MP0004215_abnormal_myocardial_fiber0.97243648
92MP0005375_adipose_tissue_phenotype0.96848460
93MP0004087_abnormal_muscle_fiber0.96061587
94MP0001533_abnormal_skeleton_physiology0.94572505
95* MP0001614_abnormal_blood_vessel0.93717775
96MP0000372_irregular_coat_pigmentation0.93215715
97MP0000733_abnormal_muscle_development0.93140559
98MP0003724_increased_susceptibility_to0.92932102
99MP0002168_other_aberrant_phenotype0.92032796
100MP0003941_abnormal_skin_development0.89073839
101MP0005058_abnormal_lysosome_morphology0.89012584
102MP0003115_abnormal_respiratory_system0.88647014
103MP0010630_abnormal_cardiac_muscle0.86943869
104MP0001299_abnormal_eye_distance/0.86276043
105MP0005369_muscle_phenotype0.86095013
106MP0002925_abnormal_cardiovascular_devel0.85195839
107MP0005167_abnormal_blood-brain_barrier0.84604711
108* MP0002113_abnormal_skeleton_development0.84073909
109* MP0001175_abnormal_lung_morphology0.83980995
110MP0002877_abnormal_melanocyte_morpholog0.82645231
111MP0003942_abnormal_urinary_system0.81984070
112MP0004510_myositis0.80843791
113MP0000230_abnormal_systemic_arterial0.80342880
114MP0004185_abnormal_adipocyte_glucose0.79238272
115MP0002166_altered_tumor_susceptibility0.79095533
116MP0001756_abnormal_urination0.79059568
117MP0003638_abnormal_response/metabolism_0.79029722
118MP0004019_abnormal_vitamin_homeostasis0.77953471
119MP0010386_abnormal_urinary_bladder0.75987372
120* MP0003795_abnormal_bone_structure0.75188957
121MP0002249_abnormal_larynx_morphology0.75165733
122MP0001502_abnormal_circadian_rhythm0.74531306
123MP0001177_atelectasis0.74057442
124MP0001243_abnormal_dermal_layer0.73986793
125MP0005379_endocrine/exocrine_gland_phen0.73931740
126MP0003646_muscle_fatigue0.73266837
127* MP0004085_abnormal_heartbeat0.72816252
128MP0001348_abnormal_lacrimal_gland0.72156915
129MP0000003_abnormal_adipose_tissue0.71942827
130MP0001324_abnormal_eye_pigmentation0.71875655
131MP0002876_abnormal_thyroid_physiology0.71014384
132MP0010678_abnormal_skin_adnexa0.70513877
133MP0000762_abnormal_tongue_morphology0.69709457
134MP0000759_abnormal_skeletal_muscle0.68856580
135MP0000383_abnormal_hair_follicle0.68763869
136MP0000613_abnormal_salivary_gland0.68533654
137MP0005075_abnormal_melanosome_morpholog0.68021988
138MP0010352_gastrointestinal_tract_polyps0.66868158
139MP0000537_abnormal_urethra_morphology0.66743173
140MP0000428_abnormal_craniofacial_morphol0.66541366
141* MP0000266_abnormal_heart_morphology0.66182133
142MP0003935_abnormal_craniofacial_develop0.65721437
143MP0000049_abnormal_middle_ear0.65330591
144MP0003936_abnormal_reproductive_system0.64294514
145MP0005645_abnormal_hypothalamus_physiol0.63413908
146MP0002127_abnormal_cardiovascular_syste0.63077331

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.35206449
2Protrusio acetabuli (HP:0003179)5.96181973
3Concave nail (HP:0001598)5.73835445
4Aortic aneurysm (HP:0004942)5.25252051
5Flat capital femoral epiphysis (HP:0003370)5.11784169
6Aortic dissection (HP:0002647)5.03363100
7Sparse lateral eyebrow (HP:0005338)4.96052624
8Broad metatarsal (HP:0001783)4.70598263
9Cerebral aneurysm (HP:0004944)4.33245690
10Ankle contracture (HP:0006466)4.17620613
11Infantile muscular hypotonia (HP:0008947)4.11145805
12Vascular tortuosity (HP:0004948)3.83308366
13Abnormality of nail color (HP:0100643)3.73191886
14Abnormality of the proximal phalanges of the hand (HP:0009834)3.59890563
15Cervical subluxation (HP:0003308)3.59284342
16Shallow orbits (HP:0000586)3.44917526
17Bladder diverticulum (HP:0000015)3.43504052
18Soft skin (HP:0000977)3.38099336
19Abnormality of the ischium (HP:0003174)3.36836736
20Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)3.34215710
21Hypoplastic ischia (HP:0003175)3.32399658
22Neonatal short-limb short stature (HP:0008921)3.31458596
23Spinal rigidity (HP:0003306)3.29281483
24Wormian bones (HP:0002645)3.26951120
25Type 1 muscle fiber predominance (HP:0003803)3.26722043
26Abnormality of the femoral head (HP:0003368)3.22598994
27Abnormality of the epiphysis of the femoral head (HP:0010574)3.21423188
28Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.20536959
29Abnormality of femoral epiphyses (HP:0006499)3.20536959
30Atrophic scars (HP:0001075)3.18220356
31Increased connective tissue (HP:0009025)3.11531474
32Dilatation of the ascending aorta (HP:0005111)3.07374128
33Follicular hyperkeratosis (HP:0007502)3.06795804
34Arterial tortuosity (HP:0005116)3.00015978
35Mitral valve prolapse (HP:0001634)2.97935247
36White forelock (HP:0002211)2.95380614
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.94745096
38Osteolytic defects of the hand bones (HP:0009699)2.94745096
39Complement deficiency (HP:0004431)2.93112954
40Blue sclerae (HP:0000592)2.86483134
41Abnormality of dentin (HP:0010299)2.82939927
42Pili torti (HP:0003777)2.82441978
43Patchy hypopigmentation of hair (HP:0011365)2.82031394
44Glomerulonephritis (HP:0000099)2.81686390
45* Pulmonary artery stenosis (HP:0004415)2.80529882
46Ulnar bowing (HP:0003031)2.80180132
47Muscle fiber splitting (HP:0003555)2.78984778
48Increased variability in muscle fiber diameter (HP:0003557)2.77371256
49Hypoplasia of the odontoid process (HP:0003311)2.76093588
50Right ventricular cardiomyopathy (HP:0011663)2.74545865
51Interstitial pulmonary disease (HP:0006530)2.73855729
52Spondylolisthesis (HP:0003302)2.71972218
53Systemic lupus erythematosus (HP:0002725)2.68317030
54Aneurysm (HP:0002617)2.67112680
55Epiphyseal dysplasia (HP:0002656)2.65378211
56Fragile skin (HP:0001030)2.65186485
57Abnormality of complement system (HP:0005339)2.62727343
58Wrist flexion contracture (HP:0001239)2.62456280
59Oligomenorrhea (HP:0000876)2.62332253
60Cupped ribs (HP:0000887)2.56151033
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.55920620
62Small epiphyses (HP:0010585)2.53789776
63Absent frontal sinuses (HP:0002688)2.52784400
64Osteoarthritis (HP:0002758)2.47735617
65Exostoses (HP:0100777)2.47325865
66Spinal cord compression (HP:0002176)2.46229723
67Mildly elevated creatine phosphokinase (HP:0008180)2.44685275
68Vertebral compression fractures (HP:0002953)2.43357508
69Abnormality of skeletal muscle fiber size (HP:0012084)2.42611213
70Lip pit (HP:0100267)2.37832295
71* Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.34977679
72Wide anterior fontanel (HP:0000260)2.32824391
73Hyperextensible skin (HP:0000974)2.32648096
74Camptodactyly of toe (HP:0001836)2.32512417
75Vitreoretinal degeneration (HP:0000655)2.30236758
76Peritonitis (HP:0002586)2.29886031
77Abnormality of the odontoid process (HP:0003310)2.26709045
78Nephritis (HP:0000123)2.26198608
79Mitral regurgitation (HP:0001653)2.25494941
80Generalized amyotrophy (HP:0003700)2.24678865
81Joint laxity (HP:0001388)2.22438630
82Abnormality of the calf musculature (HP:0001430)2.22385533
83Knee flexion contracture (HP:0006380)2.20558337
84Hip contracture (HP:0003273)2.20555293
85Hematochezia (HP:0002573)2.20143724
86Elbow flexion contracture (HP:0002987)2.18228885
87Macroorchidism (HP:0000053)2.17965122
88Scapular winging (HP:0003691)2.17672014
89Redundant skin (HP:0001582)2.15722690
90Hyporeflexia of lower limbs (HP:0002600)2.15545830
91Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.14484612
92Disproportionate tall stature (HP:0001519)2.12751745
93Ulnar deviation of the wrist (HP:0003049)2.12690858
94Limited hip movement (HP:0008800)2.12250550
95Lipoatrophy (HP:0100578)2.12115517
96Astrocytoma (HP:0009592)2.07731690
97Abnormality of the astrocytes (HP:0100707)2.07731690
98Aortic regurgitation (HP:0001659)2.05613513
99Hypotrichosis (HP:0001006)2.04827004
100Platyspondyly (HP:0000926)2.04823788
101Polycythemia (HP:0001901)2.04801813
102Radial bowing (HP:0002986)2.04797596
103Joint stiffness (HP:0001387)2.04750047
104Abnormality of the nasal septum (HP:0000419)2.04588935
105Beaking of vertebral bodies (HP:0004568)2.04265312
106Abnormality of the acetabulum (HP:0003170)2.03930591
107Round ear (HP:0100830)2.03700117
108Natal tooth (HP:0000695)2.03342126
109J-shaped sella turcica (HP:0002680)2.03091408
110Cardiovascular calcification (HP:0011915)2.02464159
111Genu recurvatum (HP:0002816)2.01163227
112Ectopia lentis (HP:0001083)2.00491233
113Hamartoma of the eye (HP:0010568)2.00487706
114Striae distensae (HP:0001065)2.00175375
115Alopecia of scalp (HP:0002293)1.99279988
116Broad ribs (HP:0000885)1.99142602
117Mesomelia (HP:0003027)1.97900151
118Delayed closure of the anterior fontanelle (HP:0001476)1.97890311
119Ovoid vertebral bodies (HP:0003300)1.96669921
120Hypoplasia of the iris (HP:0007676)1.96129727
121Aortic valve stenosis (HP:0001650)1.95278753
122Subcapsular cataract (HP:0000523)1.94968892
123Pheochromocytoma (HP:0002666)1.94654591
124Biconcave vertebral bodies (HP:0004586)1.94130309
125Mild short stature (HP:0003502)1.93656080
126Bowed forearm bones (HP:0003956)1.92720645
127Bowing of the arm (HP:0006488)1.92720645
128Ventricular tachycardia (HP:0004756)1.92536635
129Bell-shaped thorax (HP:0001591)1.92102405
130Microdontia (HP:0000691)1.91669051
131Overgrowth (HP:0001548)1.91164207
132Slender build (HP:0001533)1.89606867
133Advanced eruption of teeth (HP:0006288)1.89079338
134Irregular epiphyses (HP:0010582)1.88189233
135Sudden death (HP:0001699)1.88141251
136Tarsal synostosis (HP:0008368)1.87936482
137Atrial fibrillation (HP:0005110)1.87651010
138Coxa vara (HP:0002812)1.87146503
139Distal lower limb muscle weakness (HP:0009053)1.86939606
140Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86138716
141Absent epiphyses (HP:0010577)1.85974929
142Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85974929
143Abnormality of molar morphology (HP:0011070)1.85029501
144Abnormality of molar (HP:0011077)1.85029501
145Bowel diverticulosis (HP:0005222)1.84544696
146Polar cataract (HP:0010696)1.84285959
147Thin ribs (HP:0000883)1.83666711
148Protruding ear (HP:0000411)1.83117889
149Short nail (HP:0001799)1.83104009
150Irregular vertebral endplates (HP:0003301)1.82691899
151* Abnormality of the epiphyses of the hand (HP:0005924)1.81323272
152Scotoma (HP:0000575)1.81091525
153Papilledema (HP:0001085)1.80833018
154Pseudobulbar signs (HP:0002200)1.79865576
155Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.79554352
156Abnormality of the parathyroid morphology (HP:0011766)1.78668414
157* Abnormal delivery (HP:0001787)1.76921517
158Joint contractures involving the joints of the feet (HP:0100492)1.76885963
159Premature skin wrinkling (HP:0100678)1.74697580
160Obstructive sleep apnea (HP:0002870)1.73718997
161Osteopenia (HP:0000938)1.70029277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.44233087
2TTN4.31190295
3DDR23.91391470
4TIE13.74776449
5TGFBR23.74015375
6MST43.44851220
7EPHA33.30968536
8EPHA23.25374692
9PDGFRA3.11059742
10EPHB22.86853142
11TRIB32.48383980
12DMPK2.44850476
13ERN12.01812271
14LATS11.96309862
15FER1.91276522
16MAP3K61.68178545
17GRK11.64614229
18MET1.64599826
19ZAK1.63541813
20MAP3K31.62242471
21PAK21.58973424
22PTK2B1.53856953
23TRPM71.52951186
24EPHB11.46730213
25RIPK11.46491940
26PAK31.44801608
27PRKCI1.33361006
28FRK1.33091130
29PKN21.31218539
30ILK1.28317822
31EEF2K1.27897215
32PDGFRB1.27420705
33ROCK11.25422489
34LATS21.21441495
35LMTK21.17763154
36TNK21.16554300
37LRRK21.13412232
38PIK3CA1.12826809
39PRKD11.11022253
40NEK91.10040472
41STK38L1.08889094
42PTK21.05045126
43MAPK151.04564636
44KDR1.04529710
45MUSK1.02386593
46NUAK11.02292225
47BMX1.01953500
48PAK41.00394038
49FGFR21.00006592
50CDC42BPA0.95353813
51PHKG20.92983030
52PHKG10.92983030
53CDK120.90639494
54PRKCH0.90610868
55LIMK10.87100936
56NTRK10.86799688
57ROCK20.85130359
58PIK3CG0.83252628
59ERBB30.82767047
60BRSK20.82292251
61KIT0.81708570
62PTK60.81069537
63DAPK30.79302052
64FGFR40.79286881
65PRKG20.79109563
66SIK10.78267741
67PDK20.78115649
68AKT30.74354342
69PRKAA20.73613451
70TGFBR10.71777925
71OXSR10.70869651
72INSRR0.66112376
73PIM20.65249577
74TESK10.64973387
75ERBB20.64815904
76FGFR30.64713435
77HIPK20.61480059
78GSK3A0.60061935
79STK30.59972541
80OBSCN0.59609084
81MAPKAPK30.59036442
82PRKD20.58954111
83CHUK0.56569804
84MARK20.56320093
85MST1R0.55785886
86RET0.54131586
87MAPKAPK50.52412843
88JAK10.51333779
89PRKCE0.50550498
90FGFR10.49880661
91ICK0.48514060
92RPS6KA20.48378839
93JAK20.48231902
94ZAP700.47894567
95MAPK120.46901936
96CAMK1D0.46800628
97MAP2K60.46637747
98IRAK10.45933114
99ADRBK10.45588486
100MAP2K30.44561144
101PRKD30.44539350
102MAP3K70.43286272
103MAP2K10.42919988
104INSR0.42580068
105ABL20.41939111
106STK240.41559648
107WNK10.41234763
108STK390.39132839
109MAPK30.38814555
110CAMK2D0.38654244
111STK380.38096512
112SRC0.37662648
113NME20.37130397
114WNK40.36920600
115STK100.36569003
116CSK0.35231712
117MAP2K20.35209813
118MAP3K20.33416177
119PLK20.32887620
120NLK0.32150915
121SGK20.32016322
122NEK60.31715834
123SGK30.31372924
124MTOR0.29440581
125TAOK10.29438651
126AKT20.29415948
127IGF1R0.28820086
128WEE10.28244469
129FLT30.28104161
130ABL10.27349042
131CAMK1G0.27303635
132MAPK10.27247756
133SGK2230.26730817
134SGK4940.26730817
135MAPKAPK20.26290445
136EGFR0.25903113
137MAPK70.25374694
138PDK30.25119451
139PDK40.25119451
140MAPK40.24125924

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.63791475
2Focal adhesion_Homo sapiens_hsa045103.18797078
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.90844543
4Dilated cardiomyopathy_Homo sapiens_hsa054142.86157317
5Protein digestion and absorption_Homo sapiens_hsa049742.56017995
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.48899362
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.29425910
8Circadian rhythm_Homo sapiens_hsa047102.27892787
9TGF-beta signaling pathway_Homo sapiens_hsa043502.22331712
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.22277915
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.20635989
12Fatty acid elongation_Homo sapiens_hsa000622.14506741
13Amoebiasis_Homo sapiens_hsa051462.10563360
14Tyrosine metabolism_Homo sapiens_hsa003502.04276791
15Malaria_Homo sapiens_hsa051442.01457883
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.96388362
17Proteoglycans in cancer_Homo sapiens_hsa052051.90126730
18ABC transporters_Homo sapiens_hsa020101.84890655
19Adherens junction_Homo sapiens_hsa045201.75168146
20Mineral absorption_Homo sapiens_hsa049781.65035570
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60987236
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.58787345
23Histidine metabolism_Homo sapiens_hsa003401.58448188
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49102743
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.44986146
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.37978395
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37850836
28Phenylalanine metabolism_Homo sapiens_hsa003601.33591056
29Sulfur metabolism_Homo sapiens_hsa009201.33465029
30Small cell lung cancer_Homo sapiens_hsa052221.30429508
31Viral myocarditis_Homo sapiens_hsa054161.28980374
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.27126508
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.24663546
34Hippo signaling pathway_Homo sapiens_hsa043901.22323336
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22007615
36Complement and coagulation cascades_Homo sapiens_hsa046101.16639445
37Bladder cancer_Homo sapiens_hsa052191.14223599
38Phototransduction_Homo sapiens_hsa047441.13738377
39Caffeine metabolism_Homo sapiens_hsa002321.12861866
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12311790
41Tight junction_Homo sapiens_hsa045301.12056998
42Platelet activation_Homo sapiens_hsa046111.11535661
43Tryptophan metabolism_Homo sapiens_hsa003801.08666363
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08414216
45Rap1 signaling pathway_Homo sapiens_hsa040151.05573626
46Chemical carcinogenesis_Homo sapiens_hsa052041.04318070
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03354411
48Phagosome_Homo sapiens_hsa041451.01545396
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98733225
50Melanoma_Homo sapiens_hsa052180.95373120
51Renal cell carcinoma_Homo sapiens_hsa052110.93490165
52Pathways in cancer_Homo sapiens_hsa052000.93469470
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.91117682
54MicroRNAs in cancer_Homo sapiens_hsa052060.90436518
55Renin secretion_Homo sapiens_hsa049240.88494161
56Toxoplasmosis_Homo sapiens_hsa051450.88152712
57Axon guidance_Homo sapiens_hsa043600.87856552
58Thyroid hormone synthesis_Homo sapiens_hsa049180.85872988
59Rheumatoid arthritis_Homo sapiens_hsa053230.84743989
60Ras signaling pathway_Homo sapiens_hsa040140.84471106
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84439998
62beta-Alanine metabolism_Homo sapiens_hsa004100.84280180
63Ovarian steroidogenesis_Homo sapiens_hsa049130.83132133
64Chronic myeloid leukemia_Homo sapiens_hsa052200.82298473
65Salmonella infection_Homo sapiens_hsa051320.81288435
66Fatty acid metabolism_Homo sapiens_hsa012120.80820757
67Arachidonic acid metabolism_Homo sapiens_hsa005900.79576942
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79142176
69Lysine degradation_Homo sapiens_hsa003100.78971550
70Lysosome_Homo sapiens_hsa041420.78533017
71Pancreatic cancer_Homo sapiens_hsa052120.78417288
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78331084
73Peroxisome_Homo sapiens_hsa041460.78309923
74Hepatitis C_Homo sapiens_hsa051600.78092007
75Basal cell carcinoma_Homo sapiens_hsa052170.77894335
76Nitrogen metabolism_Homo sapiens_hsa009100.77217754
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.76198873
78HIF-1 signaling pathway_Homo sapiens_hsa040660.75902707
79Prolactin signaling pathway_Homo sapiens_hsa049170.75339793
80Prostate cancer_Homo sapiens_hsa052150.74998602
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74593829
82Glutathione metabolism_Homo sapiens_hsa004800.73274470
83Cardiac muscle contraction_Homo sapiens_hsa042600.73042230
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72343352
85TNF signaling pathway_Homo sapiens_hsa046680.72270071
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72249656
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72070752
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69201615
89AMPK signaling pathway_Homo sapiens_hsa041520.68417483
90Gap junction_Homo sapiens_hsa045400.68239766
91Pertussis_Homo sapiens_hsa051330.67131216
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66365235
93Vibrio cholerae infection_Homo sapiens_hsa051100.64598678
94N-Glycan biosynthesis_Homo sapiens_hsa005100.63659923
95Pancreatic secretion_Homo sapiens_hsa049720.61756983
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61627600
97Glioma_Homo sapiens_hsa052140.60852212
98Osteoclast differentiation_Homo sapiens_hsa043800.59594099
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59348355
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57863227
101Sphingolipid metabolism_Homo sapiens_hsa006000.57859293
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57545966
103PPAR signaling pathway_Homo sapiens_hsa033200.56388976
104Notch signaling pathway_Homo sapiens_hsa043300.55521118
105Melanogenesis_Homo sapiens_hsa049160.54742830
106Oxytocin signaling pathway_Homo sapiens_hsa049210.54407786
107Starch and sucrose metabolism_Homo sapiens_hsa005000.54373718
108Insulin resistance_Homo sapiens_hsa049310.54189065
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53977042
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53471687
111cAMP signaling pathway_Homo sapiens_hsa040240.53446736
112Other glycan degradation_Homo sapiens_hsa005110.53317185
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.52510959
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51695786
115Fatty acid biosynthesis_Homo sapiens_hsa000610.51365596
116Prion diseases_Homo sapiens_hsa050200.49980753
117Estrogen signaling pathway_Homo sapiens_hsa049150.49798742
118Protein export_Homo sapiens_hsa030600.48855794
119Apoptosis_Homo sapiens_hsa042100.48150978
120Thyroid cancer_Homo sapiens_hsa052160.47980578
121MAPK signaling pathway_Homo sapiens_hsa040100.47593441
122Dorso-ventral axis formation_Homo sapiens_hsa043200.47457219
123Hedgehog signaling pathway_Homo sapiens_hsa043400.47088841
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.46359430
125Wnt signaling pathway_Homo sapiens_hsa043100.45723090
126Endocytosis_Homo sapiens_hsa041440.44322111
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44263168
128VEGF signaling pathway_Homo sapiens_hsa043700.44220988
129Staphylococcus aureus infection_Homo sapiens_hsa051500.44014315
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44000474
131Gastric acid secretion_Homo sapiens_hsa049710.43906469
132GnRH signaling pathway_Homo sapiens_hsa049120.43681728
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43620320
134Renin-angiotensin system_Homo sapiens_hsa046140.42439363
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42138083
136Insulin signaling pathway_Homo sapiens_hsa049100.41753583
137Leishmaniasis_Homo sapiens_hsa051400.41750331
138Acute myeloid leukemia_Homo sapiens_hsa052210.41321076
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40806093
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39419617
141Fatty acid degradation_Homo sapiens_hsa000710.39409434
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.38503521
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37877381
144Tuberculosis_Homo sapiens_hsa051520.36773813
145FoxO signaling pathway_Homo sapiens_hsa040680.36632117

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