MGST1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.06666954
2L-phenylalanine catabolic process (GO:0006559)7.06666954
3L-phenylalanine metabolic process (GO:0006558)6.77275444
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.77275444
5aromatic amino acid family catabolic process (GO:0009074)6.35491646
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.16630550
7tryptophan catabolic process (GO:0006569)5.73539662
8indole-containing compound catabolic process (GO:0042436)5.73539662
9indolalkylamine catabolic process (GO:0046218)5.73539662
10bile acid biosynthetic process (GO:0006699)5.72090604
11alpha-linolenic acid metabolic process (GO:0036109)5.69754572
12kynurenine metabolic process (GO:0070189)5.58790300
13glyoxylate metabolic process (GO:0046487)5.53844736
14tryptophan metabolic process (GO:0006568)5.41150878
15urea metabolic process (GO:0019627)5.40744678
16urea cycle (GO:0000050)5.40744678
17complement activation, alternative pathway (GO:0006957)5.38201472
18sulfur amino acid catabolic process (GO:0000098)5.31469894
19high-density lipoprotein particle remodeling (GO:0034375)5.25067004
20cysteine metabolic process (GO:0006534)5.21722944
21negative regulation of fibrinolysis (GO:0051918)5.19518745
22peptidyl-glutamic acid carboxylation (GO:0017187)5.10958353
23protein carboxylation (GO:0018214)5.10958353
24regulation of protein activation cascade (GO:2000257)5.09480433
25daunorubicin metabolic process (GO:0044597)5.07079308
26polyketide metabolic process (GO:0030638)5.07079308
27doxorubicin metabolic process (GO:0044598)5.07079308
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.01394845
29regulation of fibrinolysis (GO:0051917)5.00919272
30nitrogen cycle metabolic process (GO:0071941)4.97747723
31regulation of triglyceride catabolic process (GO:0010896)4.95103598
32bile acid metabolic process (GO:0008206)4.85486914
33regulation of complement activation (GO:0030449)4.79363305
34serine family amino acid catabolic process (GO:0009071)4.72774104
35reverse cholesterol transport (GO:0043691)4.64534166
36regulation of cholesterol esterification (GO:0010872)4.62481458
37protein-lipid complex remodeling (GO:0034368)4.62064944
38macromolecular complex remodeling (GO:0034367)4.62064944
39plasma lipoprotein particle remodeling (GO:0034369)4.62064944
40aromatic amino acid family metabolic process (GO:0009072)4.60889127
41homocysteine metabolic process (GO:0050667)4.58835123
42acylglycerol homeostasis (GO:0055090)4.57537052
43triglyceride homeostasis (GO:0070328)4.57537052
44amino-acid betaine metabolic process (GO:0006577)4.53929447
45aminoglycoside antibiotic metabolic process (GO:0030647)4.52937065
46tyrosine metabolic process (GO:0006570)4.52364840
47plasma lipoprotein particle clearance (GO:0034381)4.43827127
48primary alcohol catabolic process (GO:0034310)4.42881823
49lysine metabolic process (GO:0006553)4.40100110
50lysine catabolic process (GO:0006554)4.40100110
51cellular glucuronidation (GO:0052695)4.39229062
52phospholipid efflux (GO:0033700)4.39017261
53alpha-amino acid catabolic process (GO:1901606)4.36027502
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.29549107
55negative regulation of sterol transport (GO:0032372)4.26705878
56negative regulation of cholesterol transport (GO:0032375)4.26705878
57ethanol oxidation (GO:0006069)4.18603341
58cellular ketone body metabolic process (GO:0046950)4.17157061
59L-serine metabolic process (GO:0006563)4.15973047
60coenzyme catabolic process (GO:0009109)4.13437409
61bile acid and bile salt transport (GO:0015721)4.11362251
62benzene-containing compound metabolic process (GO:0042537)4.08995477
63cholesterol efflux (GO:0033344)4.05623884
64cellular amino acid catabolic process (GO:0009063)4.05590349
65indolalkylamine metabolic process (GO:0006586)4.04973641
66exogenous drug catabolic process (GO:0042738)3.99504914
67imidazole-containing compound metabolic process (GO:0052803)3.98646759
68cellular biogenic amine catabolic process (GO:0042402)3.98110640
69amine catabolic process (GO:0009310)3.98110640
70uronic acid metabolic process (GO:0006063)3.96093605
71glucuronate metabolic process (GO:0019585)3.96093605
72glycine metabolic process (GO:0006544)3.96073761
73positive regulation of lipid catabolic process (GO:0050996)3.93614536
74serine family amino acid metabolic process (GO:0009069)3.90097757
75glutamate metabolic process (GO:0006536)3.89267455
76aldehyde catabolic process (GO:0046185)3.88803198
77plasma lipoprotein particle assembly (GO:0034377)3.87003585
78negative regulation of lipase activity (GO:0060192)3.84106889
79low-density lipoprotein particle remodeling (GO:0034374)3.82328401
80fibrinolysis (GO:0042730)3.79699870
81very-low-density lipoprotein particle assembly (GO:0034379)3.76353624
82cellular modified amino acid catabolic process (GO:0042219)3.76138029
83acetyl-CoA metabolic process (GO:0006084)3.75659786
84arginine metabolic process (GO:0006525)3.73536118
85positive regulation of triglyceride lipase activity (GO:0061365)3.73193694
86positive regulation of lipoprotein lipase activity (GO:0051006)3.73193694
87short-chain fatty acid metabolic process (GO:0046459)3.72349811
88response to nitrosative stress (GO:0051409)3.70535982
89phospholipid homeostasis (GO:0055091)3.70136775
90positive regulation of fatty acid beta-oxidation (GO:0032000)3.69025514
91organic acid catabolic process (GO:0016054)3.68857509
92carboxylic acid catabolic process (GO:0046395)3.68857509
93drug catabolic process (GO:0042737)3.67788236
94fatty acid beta-oxidation (GO:0006635)3.66631831
95serine family amino acid biosynthetic process (GO:0009070)3.66562554
96cholesterol homeostasis (GO:0042632)3.66510482
97chaperone-mediated protein transport (GO:0072321)3.66170977
98dicarboxylic acid biosynthetic process (GO:0043650)3.65595749
99fatty acid oxidation (GO:0019395)3.65158958
100complement activation (GO:0006956)3.64872095
101cofactor catabolic process (GO:0051187)3.62167695
102sterol homeostasis (GO:0055092)3.60746088
103ketone body metabolic process (GO:1902224)3.60227956
104complement activation, classical pathway (GO:0006958)3.60219450
105lipid oxidation (GO:0034440)3.58946054
106monocarboxylic acid catabolic process (GO:0072329)3.58342646
107plasma lipoprotein particle organization (GO:0071827)3.57587574
108cytolysis (GO:0019835)3.57520492
109proteasome assembly (GO:0043248)3.57173345
110protein activation cascade (GO:0072376)3.56643321
111ethanol metabolic process (GO:0006067)3.38391604
112ATP synthesis coupled proton transport (GO:0015986)3.38307557
113energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38307557
114establishment of integrated proviral latency (GO:0075713)3.33021812
115biotin metabolic process (GO:0006768)3.22997177
116primary alcohol metabolic process (GO:0034308)3.20402779
117omega-hydroxylase P450 pathway (GO:0097267)3.14616579
118establishment of protein localization to mitochondrial membrane (GO:0090151)3.07566990
119negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05026489
120epoxygenase P450 pathway (GO:0019373)3.04762211
121purine nucleobase biosynthetic process (GO:0009113)3.04084901
122triglyceride catabolic process (GO:0019433)3.03247290
123chromatin remodeling at centromere (GO:0031055)2.97283907
124mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.94117139
125CENP-A containing nucleosome assembly (GO:0034080)2.91248714
126respiratory electron transport chain (GO:0022904)2.89078946
127drug metabolic process (GO:0017144)2.85949392
128electron transport chain (GO:0022900)2.81333764
129regulation of plasminogen activation (GO:0010755)2.80421551
130nucleotide-sugar biosynthetic process (GO:0009226)2.80175571
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78617033
132phenylpropanoid metabolic process (GO:0009698)2.78124283
133water-soluble vitamin biosynthetic process (GO:0042364)2.78039022
134acylglycerol catabolic process (GO:0046464)2.75685644
135neutral lipid catabolic process (GO:0046461)2.75685644
136negative regulation of ligase activity (GO:0051352)2.75433298
137negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75433298
138cellular aldehyde metabolic process (GO:0006081)2.75133681
139intestinal cholesterol absorption (GO:0030299)2.72748103
140ribosomal large subunit biogenesis (GO:0042273)2.71247263
141regulation of cellular amino acid metabolic process (GO:0006521)2.71162945
142L-methionine salvage (GO:0071267)2.70805351
143L-methionine biosynthetic process (GO:0071265)2.70805351
144amino acid salvage (GO:0043102)2.70805351
145tetrahydrofolate metabolic process (GO:0046653)2.70051321
146nucleobase biosynthetic process (GO:0046112)2.69364970
147regulation of mitochondrial translation (GO:0070129)2.64237105
148termination of RNA polymerase III transcription (GO:0006386)2.62446319
149transcription elongation from RNA polymerase III promoter (GO:0006385)2.62446319
150retinal metabolic process (GO:0042574)2.61650400
151L-ascorbic acid metabolic process (GO:0019852)2.61389382
152quinone metabolic process (GO:1901661)2.61133660
153positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60462242
154rRNA modification (GO:0000154)2.58922438
155anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.53357469
156oxaloacetate metabolic process (GO:0006107)2.53114445
157heme transport (GO:0015886)2.50024897
158glycoside metabolic process (GO:0016137)2.49505940
159acyl-CoA metabolic process (GO:0006637)2.49499491
160thioester metabolic process (GO:0035383)2.49499491
161anterior/posterior axis specification, embryo (GO:0008595)2.49497119

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.99776578
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.88990196
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.63303760
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.28807315
5* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.84846883
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.08235457
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.86924809
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38565268
9E2F7_22180533_ChIP-Seq_HELA_Human4.13915999
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.91323715
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.72511280
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.71890296
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37516813
14GABP_17652178_ChIP-ChIP_JURKAT_Human3.32087553
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.92571652
16AR_21909140_ChIP-Seq_LNCAP_Human2.90568961
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76607186
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.50608410
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47967328
20* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46670728
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43222973
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36696444
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34176564
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29026222
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28543401
26* ELK1_19687146_ChIP-ChIP_HELA_Human2.26550458
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23136644
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19059824
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14127979
30CLOCK_20551151_ChIP-Seq_293T_Human2.04019544
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01840138
32* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2969425
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99716675
34* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.96676025
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.96404811
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76730580
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71955785
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71417897
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.64047080
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.60141771
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58218331
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56366914
43GATA1_22025678_ChIP-Seq_K562_Human1.56061606
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54746928
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.53488760
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50078588
47DCP1A_22483619_ChIP-Seq_HELA_Human1.49131961
48NANOG_16153702_ChIP-ChIP_HESCs_Human1.48524120
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44354840
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44131223
51TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42573208
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.39948826
53ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.38871804
54TTF2_22483619_ChIP-Seq_HELA_Human1.35025189
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34634402
56FOXP3_21729870_ChIP-Seq_TREG_Human1.34329265
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34017626
58HNF4A_19822575_ChIP-Seq_HepG2_Human1.32451145
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31267363
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28074114
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27937641
62XRN2_22483619_ChIP-Seq_HELA_Human1.26798603
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26723952
64* HTT_18923047_ChIP-ChIP_STHdh_Human1.25030092
65NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24900248
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23803689
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23739797
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23013887
69* E2F1_21310950_ChIP-Seq_MCF-7_Human1.22360431
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.22209107
71SOX17_20123909_ChIP-Seq_XEN_Mouse1.21667173
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20706465
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19725423
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19725423
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19725423
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19563696
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15450113
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14091957
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14059720
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14000675
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.12676346
82VDR_23849224_ChIP-Seq_CD4+_Human1.11901467
83NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.11746045
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11173800
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10783109
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09293121
87RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08929681
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08270143
89SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06981524
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06769209
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06429749
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03926191
93* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01815127
94MYC_18940864_ChIP-ChIP_HL60_Human1.01365836
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99720834
96GABP_19822575_ChIP-Seq_HepG2_Human0.99521884
97* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97245957
98POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96781223
99GATA4_25053715_ChIP-Seq_YYC3_Human0.95539217
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93940638
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92055159
102* EOMES_21245162_ChIP-Seq_HESCs_Human0.91328980
103NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89162051
104TP63_17297297_ChIP-ChIP_HaCaT_Human0.87182967
105NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86711101
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86711101
107ESR2_21235772_ChIP-Seq_MCF-7_Human0.86048129
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86008858
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85896752
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83889517
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.83650125
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83635011
113SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82581578
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81643565
115* ELF5_23300383_ChIP-Seq_T47D_Human0.81275114
116TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80334753
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77494971
118ZNF263_19887448_ChIP-Seq_K562_Human0.77236997
119HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76649632
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75301182
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74283289
122ESR1_21235772_ChIP-Seq_MCF-7_Human0.73878914
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73655256
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73623458
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.73225640
126KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72398814
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.70106512
128PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.69115489
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.66248970
130RARA_24833708_ChIP-Seq_LIVER_Mouse0.65217890
131SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64352005
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60714209
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.60595183
134BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60542197
135CEBPB_22108803_ChIP-Seq_LS180_Human0.60475828
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.60288624
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60279903
138FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60139126
139NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59533839
140TRIM28_21343339_ChIP-Seq_HEK293_Human0.59075473
141SOX2_20726797_ChIP-Seq_SW620_Human0.58128732
142RARB_24833708_ChIP-Seq_LIVER_Mouse0.55849322
143AR_20517297_ChIP-Seq_VCAP_Human0.55632759
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55629234
145EGR1_19032775_ChIP-ChIP_M12_Human0.55171613
146STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52284217
147FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50818046
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.49845433
149BCAT_22108803_ChIP-Seq_LS180_Human0.49657746
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49450706
151LXR_22292898_ChIP-Seq_THP-1_Human0.47349272
152GATA6_25053715_ChIP-Seq_YYC3_Human0.47168133
153STAT1_17558387_ChIP-Seq_HELA_Human0.47143705
154CBP_21632823_ChIP-Seq_H3396_Human0.46681561
155MYC_19915707_ChIP-ChIP_AK7_Human0.46666037
156GATA2_19941826_ChIP-Seq_K562_Human0.46503003
157FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.46011894
158* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.45528878
159ESET_19884257_ChIP-Seq_ESCs_Mouse0.44533761
160* GATA3_24758297_ChIP-Seq_MCF-7_Human0.43705694
161GATA1_19941826_ChIP-Seq_K562_Human0.43193053
162* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.42230367
163ERG_20517297_ChIP-Seq_VCAP_Human0.39570625
164* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.39448811
165PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.39354937
166* P53_21459846_ChIP-Seq_SAOS-2_Human0.39296764
167CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37532822
168STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37442087
169SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.37157557
170TAF2_19829295_ChIP-Seq_ESCs_Human0.36941957
171SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.36792924
172CDX2_22108803_ChIP-Seq_LS180_Human0.36170042
173EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.35900168
174TBX20_22328084_ChIP-Seq_HEART_Mouse0.35413456
175TBX20_22080862_ChIP-Seq_HEART_Mouse0.35413456
176GATA2_21666600_ChIP-Seq_HMVEC_Human0.35218432

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.98307708
2MP0005360_urolithiasis7.09240356
3MP0005085_abnormal_gallbladder_physiolo6.15065914
4MP0005365_abnormal_bile_salt6.02497511
5MP0003941_abnormal_skin_development5.14004547
6MP0008875_abnormal_xenobiotic_pharmacok5.05990481
7MP0003806_abnormal_nucleotide_metabolis3.95664538
8MP0003252_abnormal_bile_duct3.74646880
9MP0010329_abnormal_lipoprotein_level3.67260699
10MP0009840_abnormal_foam_cell3.10399676
11MP0005083_abnormal_biliary_tract2.93096960
12MP0005332_abnormal_amino_acid2.68105662
13MP0003195_calcinosis2.67791873
14MP0001666_abnormal_nutrient_absorption2.48308241
15MP0003191_abnormal_cellular_cholesterol2.47280863
16MP0004957_abnormal_blastocyst_morpholog2.21733733
17MP0003693_abnormal_embryo_hatching2.19680861
18MP0002118_abnormal_lipid_homeostasis2.18617963
19MP0000609_abnormal_liver_physiology2.18537075
20MP0004019_abnormal_vitamin_homeostasis2.13408876
21MP0002138_abnormal_hepatobiliary_system1.93414509
22MP0004272_abnormal_basement_membrane1.88680571
23MP0005319_abnormal_enzyme/_coenzyme1.83912879
24MP0003868_abnormal_feces_composition1.68279391
25MP0003011_delayed_dark_adaptation1.66086521
26MP0009379_abnormal_foot_pigmentation1.65993424
27MP0008007_abnormal_cellular_replicative1.65336067
28MP0008932_abnormal_embryonic_tissue1.59972791
29MP0005584_abnormal_enzyme/coenzyme_acti1.59796276
30MP0001764_abnormal_homeostasis1.59466136
31MP0003186_abnormal_redox_activity1.56511881
32MP0010094_abnormal_chromosome_stability1.52295817
33MP0009672_abnormal_birth_weight1.50167321
34MP0005670_abnormal_white_adipose1.43996063
35MP0009697_abnormal_copulation1.42284784
36MP0000579_abnormal_nail_morphology1.42166918
37MP0003111_abnormal_nucleus_morphology1.37164112
38MP0003890_abnormal_embryonic-extraembry1.37091910
39MP0008058_abnormal_DNA_repair1.33887156
40MP0010030_abnormal_orbit_morphology1.33502916
41MP0005451_abnormal_body_composition1.31458173
42MP0003705_abnormal_hypodermis_morpholog1.30165654
43MP0009643_abnormal_urine_homeostasis1.27894344
44MP0003950_abnormal_plasma_membrane1.27721124
45MP0003136_yellow_coat_color1.27187326
46MP0003566_abnormal_cell_adhesion1.23102826
47MP0003077_abnormal_cell_cycle1.21821964
48MP0006292_abnormal_olfactory_placode1.21718219
49MP0000762_abnormal_tongue_morphology1.21247314
50MP0002938_white_spotting1.19716512
51MP0004130_abnormal_muscle_cell1.18922075
52MP0002254_reproductive_system_inflammat1.18352650
53MP0005647_abnormal_sex_gland1.17775031
54MP0001293_anophthalmia1.16471833
55MP0000598_abnormal_liver_morphology1.15546714
56MP0003656_abnormal_erythrocyte_physiolo1.15267418
57MP0009764_decreased_sensitivity_to1.14834126
58MP0002697_abnormal_eye_size1.07953308
59MP0010352_gastrointestinal_tract_polyps1.07123705
60MP0005501_abnormal_skin_physiology1.04700415
61MP0009763_increased_sensitivity_to1.04631617
62MP0000467_abnormal_esophagus_morphology1.02727453
63MP0000604_amyloidosis1.00227456
64MP0010368_abnormal_lymphatic_system0.98812478
65MP0002971_abnormal_brown_adipose0.95811095
66MP0002295_abnormal_pulmonary_circulatio0.95325183
67MP0008469_abnormal_protein_level0.92646663
68MP0001177_atelectasis0.91900155
69MP0005636_abnormal_mineral_homeostasis0.90460282
70MP0005666_abnormal_adipose_tissue0.87907754
71MP0005408_hypopigmentation0.87873153
72MP0005334_abnormal_fat_pad0.87829077
73MP0005275_abnormal_skin_tensile0.85912023
74MP0009642_abnormal_blood_homeostasis0.85876150
75MP0002876_abnormal_thyroid_physiology0.85023117
76MP0002090_abnormal_vision0.84263817
77MP0006036_abnormal_mitochondrial_physio0.83592307
78MP0000627_abnormal_mammary_gland0.83140279
79MP0003786_premature_aging0.83113195
80MP0005376_homeostasis/metabolism_phenot0.82075529
81MP0003724_increased_susceptibility_to0.81764355
82MP0002282_abnormal_trachea_morphology0.81333682
83MP0002078_abnormal_glucose_homeostasis0.80637180
84MP0003690_abnormal_glial_cell0.78464228
85MP0002111_abnormal_tail_morphology0.78361104
86MP0001730_embryonic_growth_arrest0.77398154
87MP0005535_abnormal_body_temperature0.77249950
88MP0009765_abnormal_xenobiotic_induced0.76929953
89MP0000350_abnormal_cell_proliferation0.76167202
90MP0005023_abnormal_wound_healing0.76065207
91MP0004782_abnormal_surfactant_physiolog0.74792932
92MP0001661_extended_life_span0.74416814
93MP0005084_abnormal_gallbladder_morpholo0.73976729
94MP0003937_abnormal_limbs/digits/tail_de0.69671051
95MP0009703_decreased_birth_body0.68133609
96MP0003567_abnormal_fetal_cardiomyocyte0.67358227
97MP0000647_abnormal_sebaceous_gland0.66515586
98MP0005220_abnormal_exocrine_pancreas0.65629672
99MP0005266_abnormal_metabolism0.64838179
100MP0009053_abnormal_anal_canal0.64605149
101MP0001756_abnormal_urination0.64383775
102MP0002233_abnormal_nose_morphology0.63507152
103MP0002085_abnormal_embryonic_tissue0.62459870
104MP0005448_abnormal_energy_balance0.62324321
105MP0001286_abnormal_eye_development0.62055175
106MP0010771_integument_phenotype0.61868727
107MP0001697_abnormal_embryo_size0.61759223
108MP0004185_abnormal_adipocyte_glucose0.61558484
109MP0000639_abnormal_adrenal_gland0.59563393
110MP0002796_impaired_skin_barrier0.59383628
111MP0009115_abnormal_fat_cell0.57500941
112MP0001881_abnormal_mammary_gland0.56865369
113MP0003436_decreased_susceptibility_to0.56415184
114MP0001672_abnormal_embryogenesis/_devel0.56399065
115MP0005380_embryogenesis_phenotype0.56399065
116MP0005503_abnormal_tendon_morphology0.56367571
117MP0002136_abnormal_kidney_physiology0.51229522
118MP0005464_abnormal_platelet_physiology0.51192269
119MP0003075_altered_response_to0.49633896
120MP0003329_amyloid_beta_deposits0.49528972
121MP0005395_other_phenotype0.47111520
122MP0006035_abnormal_mitochondrial_morpho0.46832432
123MP0002837_dystrophic_cardiac_calcinosis0.46469597
124MP0001853_heart_inflammation0.46153040
125MP0002970_abnormal_white_adipose0.46119862
126MP0009384_cardiac_valve_regurgitation0.45085488
127MP0005248_abnormal_Harderian_gland0.44743073
128MP0005164_abnormal_response_to0.44660316
129MP0003638_abnormal_response/metabolism_0.44489377
130MP0002060_abnormal_skin_morphology0.44079515
131MP0005166_decreased_susceptibility_to0.43320421
132MP0004883_abnormal_blood_vessel0.43040145
133MP0004381_abnormal_hair_follicle0.42938172
134MP0008873_increased_physiological_sensi0.42510439
135MP0003953_abnormal_hormone_level0.42431816
136MP0002928_abnormal_bile_duct0.41517579
137MP0005058_abnormal_lysosome_morphology0.41357703
138MP0000249_abnormal_blood_vessel0.40354929
139MP0002168_other_aberrant_phenotype0.39446279
140MP0002132_abnormal_respiratory_system0.37864060
141MP0005375_adipose_tissue_phenotype0.37770174
142MP0010234_abnormal_vibrissa_follicle0.37605139
143MP0000230_abnormal_systemic_arterial0.37541750
144MP0008874_decreased_physiological_sensi0.36716301
145MP0001845_abnormal_inflammatory_respons0.33736818
146MP0006082_CNS_inflammation0.33672792
147MP0008438_abnormal_cutaneous_collagen0.33164630
148MP0003718_maternal_effect0.32509011
149MP0003453_abnormal_keratinocyte_physiol0.31857403

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.05682280
2Intrahepatic cholestasis (HP:0001406)6.96394530
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.95410156
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.29740151
5Xanthomatosis (HP:0000991)6.24884774
6Prolonged partial thromboplastin time (HP:0003645)6.17784767
7Hypobetalipoproteinemia (HP:0003563)6.08559874
8Complement deficiency (HP:0004431)5.55752826
9Hyperlipoproteinemia (HP:0010980)5.54679057
10Hypolipoproteinemia (HP:0010981)4.73336415
11Epidermoid cyst (HP:0200040)4.68152490
12Hyperammonemia (HP:0001987)4.60921726
13Joint hemorrhage (HP:0005261)4.56129321
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.43205400
15Hyperglycinemia (HP:0002154)4.42973120
16Hypoalphalipoproteinemia (HP:0003233)4.28509419
17Abnormality of the common coagulation pathway (HP:0010990)4.26268470
18Ketosis (HP:0001946)4.25089452
19Hyperglycinuria (HP:0003108)4.17197109
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09086955
21Abnormality of glycine metabolism (HP:0010895)4.08671877
22Abnormality of serine family amino acid metabolism (HP:0010894)4.08671877
23Abnormality of complement system (HP:0005339)4.08048299
24Hypoglycemic coma (HP:0001325)4.07632993
25Fat malabsorption (HP:0002630)4.00667558
26Abnormality of methionine metabolism (HP:0010901)3.96156772
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.95475608
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.92643765
29Hypercholesterolemia (HP:0003124)3.71079745
30Abnormality of fatty-acid metabolism (HP:0004359)3.62328023
31Abnormality of the intrinsic pathway (HP:0010989)3.60071320
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.55029459
33Reduced antithrombin III activity (HP:0001976)3.51955622
34Abnormality of pyrimidine metabolism (HP:0004353)3.49909484
35Conjugated hyperbilirubinemia (HP:0002908)3.48448874
36Acute encephalopathy (HP:0006846)3.42789103
37Increased serum pyruvate (HP:0003542)3.36016294
38Hyperbilirubinemia (HP:0002904)3.17060086
39Acute necrotizing encephalopathy (HP:0006965)3.14241373
40Abnormality of glycolysis (HP:0004366)3.12140057
41Myocardial infarction (HP:0001658)3.11821200
42Ketoacidosis (HP:0001993)3.10008562
43Steatorrhea (HP:0002570)3.07164466
44Abnormality of serum amino acid levels (HP:0003112)3.06933190
45Abnormality of nucleobase metabolism (HP:0010932)3.03459489
46Delayed CNS myelination (HP:0002188)2.96468726
47Hepatocellular carcinoma (HP:0001402)2.95151484
48Systemic lupus erythematosus (HP:0002725)2.90350357
49Skin nodule (HP:0200036)2.90184416
50Abnormality of purine metabolism (HP:0004352)2.80234492
51Abnormal mitochondria in muscle tissue (HP:0008316)2.78274473
52Dicarboxylic aciduria (HP:0003215)2.78273539
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.78273539
54Metabolic acidosis (HP:0001942)2.77877883
55Renal Fanconi syndrome (HP:0001994)2.77373048
56Spontaneous abortion (HP:0005268)2.76621123
57Increased hepatocellular lipid droplets (HP:0006565)2.75027540
58Septo-optic dysplasia (HP:0100842)2.66530485
59Lipid accumulation in hepatocytes (HP:0006561)2.65808523
60Lethargy (HP:0001254)2.65126124
61Megaloblastic anemia (HP:0001889)2.64050640
62Recurrent gram-negative bacterial infections (HP:0005420)2.62348364
63Hypochromic microcytic anemia (HP:0004840)2.61724144
64Multiple enchondromatosis (HP:0005701)2.57796393
65Macrocytic anemia (HP:0001972)2.52821025
66Vascular calcification (HP:0004934)2.51909594
67Type I transferrin isoform profile (HP:0003642)2.51029778
68Mitochondrial inheritance (HP:0001427)2.48735983
69Cerebral edema (HP:0002181)2.48140871
70Glomerulonephritis (HP:0000099)2.42012283
71Spastic diplegia (HP:0001264)2.41948793
72Progressive macrocephaly (HP:0004481)2.40723731
73Hypoglycemic seizures (HP:0002173)2.37980485
74Gout (HP:0001997)2.37877177
75Congenital, generalized hypertrichosis (HP:0004540)2.36970199
76Sparse eyelashes (HP:0000653)2.35653663
77Increased CSF lactate (HP:0002490)2.35232549
78Acanthocytosis (HP:0001927)2.35202468
79Amyloidosis (HP:0011034)2.34739396
80Abnormal gallbladder morphology (HP:0012437)2.34488297
81Hepatic necrosis (HP:0002605)2.33812730
82Generalized aminoaciduria (HP:0002909)2.29545644
83Cholelithiasis (HP:0001081)2.28476480
84Esophageal varix (HP:0002040)2.28078507
85Pancreatitis (HP:0001733)2.27586528
86Mitral stenosis (HP:0001718)2.26561865
87Cardiovascular calcification (HP:0011915)2.26100125
88Pancreatic islet-cell hyperplasia (HP:0004510)2.23375015
89Brushfield spots (HP:0001088)2.23019254
90Neonatal onset (HP:0003623)2.22653703
91Irritability (HP:0000737)2.22191393
92Hepatocellular necrosis (HP:0001404)2.19283650
93Cholecystitis (HP:0001082)2.18570199
94Abnormal gallbladder physiology (HP:0012438)2.18570199
95Abnormality of vitamin metabolism (HP:0100508)2.17421533
96Abnormal cartilage morphology (HP:0002763)2.15687038
97Vomiting (HP:0002013)2.14963940
98Sensorimotor neuropathy (HP:0007141)2.14505816
99Malnutrition (HP:0004395)2.14280838
100Hyperphosphaturia (HP:0003109)2.13780428
101Methylmalonic acidemia (HP:0002912)2.12986713
102Reticulocytopenia (HP:0001896)2.11849619
103Colon cancer (HP:0003003)2.11723155
104Abnormality of urine glucose concentration (HP:0011016)2.10125321
105Glycosuria (HP:0003076)2.10125321
106Abnormality of proline metabolism (HP:0010907)2.10073886
107Hydroxyprolinuria (HP:0003080)2.10073886
108Hemorrhage of the eye (HP:0011885)2.09614867
109Gingival bleeding (HP:0000225)2.09181185
110Renal cortical cysts (HP:0000803)2.08303635
111Hypertriglyceridemia (HP:0002155)2.04847599
112Late onset (HP:0003584)2.00643877
113Enlarged kidneys (HP:0000105)2.00538886
114Nausea (HP:0002018)1.99963584
115Menorrhagia (HP:0000132)1.99549016
116Abnormality of the labia minora (HP:0012880)1.99423977
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98233410
118Abnormality of alanine metabolism (HP:0010916)1.98233410
119Hyperalaninemia (HP:0003348)1.98233410
120Thrombophlebitis (HP:0004418)1.97426852
121Opisthotonus (HP:0002179)1.96169946
122Oral leukoplakia (HP:0002745)1.95389593
123Abnormality of the gallbladder (HP:0005264)1.90627605
124Nephritis (HP:0000123)1.89429960
125Abnormality of iron homeostasis (HP:0011031)1.89071307
126Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87580680
127Abnormal protein N-linked glycosylation (HP:0012347)1.87580680
128Abnormal protein glycosylation (HP:0012346)1.87580680
129Abnormal glycosylation (HP:0012345)1.87580680
130Methylmalonic aciduria (HP:0012120)1.86540145
131Symptomatic seizures (HP:0011145)1.86528175
132Abnormality of transition element cation homeostasis (HP:0011030)1.85438876
133Hyperinsulinemic hypoglycemia (HP:0000825)1.85339906
134Elevated hepatic transaminases (HP:0002910)1.84526242
135Proximal tubulopathy (HP:0000114)1.83694875
136Rickets (HP:0002748)1.83454927
137Increased muscle lipid content (HP:0009058)1.80041797
138Increased purine levels (HP:0004368)1.78825014
139Hyperuricemia (HP:0002149)1.78825014
140Hyperglycemia (HP:0003074)1.78410699
141Selective tooth agenesis (HP:0001592)1.78319008
142Abnormality of renal resorption (HP:0011038)1.77698884
143Poikilocytosis (HP:0004447)1.76423851
144Exertional dyspnea (HP:0002875)1.75547417
145Birth length less than 3rd percentile (HP:0003561)1.74538831
146Lactic acidosis (HP:0003128)1.73911726
147Stenosis of the external auditory canal (HP:0000402)1.73260596
148Increased serum lactate (HP:0002151)1.72071835
149Abnormal lung lobation (HP:0002101)1.71558554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.74959466
2SIK14.52962825
3ERN14.40290589
4FGFR44.02123080
5VRK23.89759337
6MST43.76214126
7BUB13.64019460
8TTK2.95333889
9CDC72.94595179
10INSRR2.65124560
11ERBB42.46234492
12MST1R2.45337584
13TAOK32.43294765
14BRSK22.31644602
15STK162.30764647
16TRIB32.27782833
17NEK12.24903128
18TSSK62.21287726
19EIF2AK32.14736659
20SRPK12.09815744
21TAF12.09131771
22PLK32.02887243
23PKN22.02878638
24NME11.95922429
25EIF2AK11.88402513
26MKNK11.86150924
27PAK41.86050525
28MKNK21.85286916
29MAP3K121.82707479
30FRK1.81414897
31TNIK1.74447692
32MAP2K41.72596726
33LATS11.71406545
34NEK91.69348644
35MAPK111.66535091
36PIK3CG1.65985490
37NME21.64593731
38TYK21.63825073
39FLT31.61511453
40VRK11.60076625
41LATS21.58807917
42DAPK21.57890849
43CAMK1D1.52664637
44EPHA21.52354910
45ZAK1.49565352
46PTK61.46920947
47ABL21.46138166
48WEE11.39883479
49FGFR21.37696873
50TRIM281.36614467
51PLK11.34449952
52NUAK11.31027378
53ACVR1B1.25935647
54MAP3K31.25694372
55BMPR1B1.24160318
56PRKAA21.20796313
57JAK21.20575727
58TBK11.19557978
59KDR1.18995671
60MAP2K31.15861813
61MAP3K141.14798094
62PLK41.12639804
63IRAK31.12344081
64JAK11.10890082
65TGFBR21.09881608
66EPHB11.03794409
67CDK61.02578096
68RIPK11.02524625
69MAP3K71.00916573
70STK240.99096724
71WNK30.94594031
72TIE10.92544753
73EPHA30.92436817
74ERBB20.92204757
75AURKB0.91857272
76BRSK10.91469991
77MET0.90133859
78EIF2AK20.89116510
79PINK10.88620460
80MAP3K100.87495752
81MAPK40.86488732
82STK38L0.83968257
83FGFR30.79082446
84PRKCZ0.78028534
85FGFR10.77098401
86TESK10.76323111
87MAP3K110.74538984
88PBK0.74500007
89MAPK150.74208463
90CSK0.73941317
91DYRK30.73664329
92GRK60.72651670
93GSK3A0.71655425
94NLK0.70763472
95CAMK1G0.70614125
96IKBKE0.70016364
97PDK40.69747065
98PDK30.69747065
99PRKACG0.68633628
100MAP2K10.68533894
101MAPK120.66377957
102EPHB20.64884489
103ARAF0.64577467
104CHEK20.63111349
105RPS6KB20.62465588
106MAPKAPK30.62411740
107ALK0.62125104
108CSNK2A10.59934584
109DYRK20.59084612
110CDK70.57702279
111PRKAA10.57294768
112MAP2K60.57157238
113CAMK2G0.56514105
114PTK20.56301391
115IGF1R0.56272686
116BCR0.55018638
117DYRK1B0.55002711
118CSNK1E0.54740687
119PDPK10.54680424
120GRK10.54420808
121TGFBR10.54229732
122SGK30.54189282
123CSNK2A20.53831732
124OXSR10.53039516
125PAK20.52046645
126ILK0.51412865
127PIK3CA0.50351112
128CSF1R0.49515704
129MAP3K130.49350837
130PRKCI0.47726826
131IRAK10.44077275
132MAPK70.43549326
133STK390.43020686
134PDK20.42714062
135FER0.41776253
136TAOK20.41078613
137PRKCQ0.40579931
138ATR0.40260300
139NEK20.40152701
140PRKCE0.39975979
141MYLK0.39657107
142DAPK10.39269090
143STK40.39082696
144MAP3K20.38145938
145CHEK10.37432694
146SGK20.37319938
147LIMK10.36466574
148MUSK0.36091531
149MAP3K50.35913650
150SCYL20.35806063
151MAPKAPK50.35694458
152CDK90.35035247
153BMX0.34721338
154CDK40.34465208
155CSNK1G10.34225578
156RET0.33432929
157ABL10.33251135
158STK30.33165695
159EGFR0.31789293
160ATM0.31569015
161TEC0.30447380
162AURKA0.29706384
163PDK10.29701499
164IRAK20.29311767
165MAP3K80.28995178
166MAP3K10.28575573
167DDR20.27997661
168MTOR0.27951536
169CHUK0.27726089
170PNCK0.27309348
171ZAP700.27046059
172MAP2K20.26939183
173ITK0.24602944
174PDGFRA0.24597875

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.34620552
2Nitrogen metabolism_Homo sapiens_hsa009103.38541258
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34862502
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.01119940
5Arginine biosynthesis_Homo sapiens_hsa002202.85634785
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.77094013
7Complement and coagulation cascades_Homo sapiens_hsa046102.65934201
8Fatty acid degradation_Homo sapiens_hsa000712.63455325
9Tryptophan metabolism_Homo sapiens_hsa003802.62720829
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57151135
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52322918
12Proteasome_Homo sapiens_hsa030502.51295916
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.37826959
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34880831
15Peroxisome_Homo sapiens_hsa041462.17582079
16Propanoate metabolism_Homo sapiens_hsa006402.17337585
17* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15122027
18PPAR signaling pathway_Homo sapiens_hsa033202.12070235
19Butanoate metabolism_Homo sapiens_hsa006502.11208873
20Fatty acid metabolism_Homo sapiens_hsa012122.01993482
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.97636493
22Caffeine metabolism_Homo sapiens_hsa002321.94975368
23* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94604569
24* Chemical carcinogenesis_Homo sapiens_hsa052041.94147954
25Histidine metabolism_Homo sapiens_hsa003401.89008177
26beta-Alanine metabolism_Homo sapiens_hsa004101.80000278
27Retinol metabolism_Homo sapiens_hsa008301.79607503
28Staphylococcus aureus infection_Homo sapiens_hsa051501.78990325
29Ribosome_Homo sapiens_hsa030101.76737483
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.72359173
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64830142
32Mismatch repair_Homo sapiens_hsa034301.62444900
33Phenylalanine metabolism_Homo sapiens_hsa003601.57276799
34Oxidative phosphorylation_Homo sapiens_hsa001901.56309354
35Protein export_Homo sapiens_hsa030601.55972061
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55938895
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53049694
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52879151
39Fatty acid elongation_Homo sapiens_hsa000621.50159202
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46665424
41Selenocompound metabolism_Homo sapiens_hsa004501.46364011
42Tyrosine metabolism_Homo sapiens_hsa003501.44679680
43Sulfur metabolism_Homo sapiens_hsa009201.44228828
44DNA replication_Homo sapiens_hsa030301.42768209
45Pyruvate metabolism_Homo sapiens_hsa006201.41780869
46Bile secretion_Homo sapiens_hsa049761.38216848
47RNA polymerase_Homo sapiens_hsa030201.36594722
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36037354
49Parkinsons disease_Homo sapiens_hsa050121.33384095
50Starch and sucrose metabolism_Homo sapiens_hsa005001.33116398
51Steroid biosynthesis_Homo sapiens_hsa001001.20825157
52Fat digestion and absorption_Homo sapiens_hsa049751.20424394
53Carbon metabolism_Homo sapiens_hsa012001.19148163
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.19032210
55ABC transporters_Homo sapiens_hsa020101.15671401
56Folate biosynthesis_Homo sapiens_hsa007901.13638561
57Biosynthesis of amino acids_Homo sapiens_hsa012301.11728411
58Homologous recombination_Homo sapiens_hsa034401.08808240
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03456747
60Huntingtons disease_Homo sapiens_hsa050160.99127508
61Sulfur relay system_Homo sapiens_hsa041220.97787935
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97722276
63Vitamin B6 metabolism_Homo sapiens_hsa007500.91120743
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90251398
65Arginine and proline metabolism_Homo sapiens_hsa003300.88063714
66Fatty acid biosynthesis_Homo sapiens_hsa000610.87016282
67Vitamin digestion and absorption_Homo sapiens_hsa049770.84765212
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.83740787
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.81613150
70Alzheimers disease_Homo sapiens_hsa050100.81067239
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80374526
72Nucleotide excision repair_Homo sapiens_hsa034200.80074752
73Glycerolipid metabolism_Homo sapiens_hsa005610.78489419
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76860583
75Non-homologous end-joining_Homo sapiens_hsa034500.74549280
76Lysine degradation_Homo sapiens_hsa003100.74090060
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73369128
78Base excision repair_Homo sapiens_hsa034100.73031127
79Spliceosome_Homo sapiens_hsa030400.73005294
80Pyrimidine metabolism_Homo sapiens_hsa002400.72991934
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69399261
82RNA transport_Homo sapiens_hsa030130.69211942
83* Glutathione metabolism_Homo sapiens_hsa004800.66629724
84Pentose phosphate pathway_Homo sapiens_hsa000300.62391372
85One carbon pool by folate_Homo sapiens_hsa006700.55814580
86RNA degradation_Homo sapiens_hsa030180.46927840
87Metabolic pathways_Homo sapiens_hsa011000.45997377
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44971482
89Basal transcription factors_Homo sapiens_hsa030220.44573946
90Purine metabolism_Homo sapiens_hsa002300.43837891
91Cell cycle_Homo sapiens_hsa041100.41040907
92Fanconi anemia pathway_Homo sapiens_hsa034600.37067283
93Prion diseases_Homo sapiens_hsa050200.35416162
94N-Glycan biosynthesis_Homo sapiens_hsa005100.34169830
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.32971117
96Galactose metabolism_Homo sapiens_hsa000520.30668853
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28336743
98Insulin resistance_Homo sapiens_hsa049310.27564602
99Mineral absorption_Homo sapiens_hsa049780.23872579
100Fructose and mannose metabolism_Homo sapiens_hsa000510.23493003
101Linoleic acid metabolism_Homo sapiens_hsa005910.21577738
102Cardiac muscle contraction_Homo sapiens_hsa042600.16931537
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16829959
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.15917694
105ECM-receptor interaction_Homo sapiens_hsa045120.14307667
106AMPK signaling pathway_Homo sapiens_hsa041520.08582791
107Glucagon signaling pathway_Homo sapiens_hsa049220.08521269
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06807086
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2160751
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.2145061
111Bladder cancer_Homo sapiens_hsa05219-0.2058407
112Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2048718
113Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2037870
114Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2001922
115Lysosome_Homo sapiens_hsa04142-0.1899089
116Regulation of autophagy_Homo sapiens_hsa04140-0.1860206
117Pertussis_Homo sapiens_hsa05133-0.1737463
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1709552
119Amoebiasis_Homo sapiens_hsa05146-0.1665995
120Renin-angiotensin system_Homo sapiens_hsa04614-0.1562324
121African trypanosomiasis_Homo sapiens_hsa05143-0.1266972
122Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1258618
123Hepatitis C_Homo sapiens_hsa05160-0.1195327
124Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1031544
125Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0852283
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0700020
127Insulin signaling pathway_Homo sapiens_hsa04910-0.0682748
128Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0202946

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