MGST2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.59928097
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.59928097
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.98990388
4L-phenylalanine metabolic process (GO:0006558)4.98990388
5neutrophil mediated immunity (GO:0002446)4.92224605
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.91179750
7L-phenylalanine catabolic process (GO:0006559)4.91179750
8ribosomal small subunit assembly (GO:0000028)4.86666341
9leukocyte aggregation (GO:0070486)4.83191750
10cellular response to zinc ion (GO:0071294)4.78911378
11antigen processing and presentation of endogenous antigen (GO:0019883)4.72843958
12regulation of cholesterol esterification (GO:0010872)4.65782397
13negative regulation of phagocytosis (GO:0050765)4.58902106
14very-low-density lipoprotein particle assembly (GO:0034379)4.49410545
15response to fungus (GO:0009620)4.23779303
16defense response to fungus (GO:0050832)4.15956620
17low-density lipoprotein particle remodeling (GO:0034374)4.06856786
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.06518018
19regulation of protein activation cascade (GO:2000257)4.03096878
20positive regulation of gamma-delta T cell activation (GO:0046645)4.00405357
21plasma lipoprotein particle assembly (GO:0034377)3.98076518
22regulation of complement activation (GO:0030449)3.97473890
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.93048603
24myeloid leukocyte mediated immunity (GO:0002444)3.91007762
25plasma lipoprotein particle remodeling (GO:0034369)3.90657880
26protein-lipid complex remodeling (GO:0034368)3.90657880
27macromolecular complex remodeling (GO:0034367)3.90657880
28cholesterol efflux (GO:0033344)3.88583156
29killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.82113861
30disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.82113861
31respiratory burst (GO:0045730)3.81717413
32high-density lipoprotein particle remodeling (GO:0034375)3.76595051
33negative regulation of growth of symbiont in host (GO:0044130)3.74657630
34negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.74657630
35modulation of growth of symbiont involved in interaction with host (GO:0044144)3.74657630
36regulation of growth of symbiont in host (GO:0044126)3.74657630
37regulation of fibrinolysis (GO:0051917)3.68201350
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.64569487
39detection of other organism (GO:0098543)3.61998524
40complement activation, alternative pathway (GO:0006957)3.60883636
41neutrophil activation involved in immune response (GO:0002283)3.55495688
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.53545180
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.53265394
44protein-lipid complex assembly (GO:0065005)3.52418347
45blood coagulation, intrinsic pathway (GO:0007597)3.46253003
46negative regulation of fibrinolysis (GO:0051918)3.44905932
47L-ascorbic acid metabolic process (GO:0019852)3.44391924
48phospholipid efflux (GO:0033700)3.43772534
49ethanol oxidation (GO:0006069)3.43134090
50interferon-gamma production (GO:0032609)3.43127282
51detection of bacterium (GO:0016045)3.43079561
52mast cell activation (GO:0045576)3.42574369
53plasma lipoprotein particle organization (GO:0071827)3.41326978
54disruption of cells of other organism (GO:0044364)3.40904218
55killing of cells of other organism (GO:0031640)3.40904218
56cellular extravasation (GO:0045123)3.38363012
57reverse cholesterol transport (GO:0043691)3.35911177
58xenobiotic catabolic process (GO:0042178)3.32235311
59regulation of B cell receptor signaling pathway (GO:0050855)3.31958002
60NADH metabolic process (GO:0006734)3.30971348
61aromatic amino acid family catabolic process (GO:0009074)3.30734874
62oxidative phosphorylation (GO:0006119)3.30417912
63T cell migration (GO:0072678)3.28632586
64epoxygenase P450 pathway (GO:0019373)3.28541842
65peptidyl-glutamic acid carboxylation (GO:0017187)3.25635338
66protein carboxylation (GO:0018214)3.25635338
67Arp2/3 complex-mediated actin nucleation (GO:0034314)3.25576138
68energy coupled proton transport, down electrochemical gradient (GO:0015985)3.23685273
69ATP synthesis coupled proton transport (GO:0015986)3.23685273
70neutrophil activation (GO:0042119)3.23571352
71respiratory electron transport chain (GO:0022904)3.23335495
72positive regulation of cellular amine metabolic process (GO:0033240)3.22146750
73protein-lipid complex subunit organization (GO:0071825)3.19861887
74intestinal absorption (GO:0050892)3.19654245
75intestinal cholesterol absorption (GO:0030299)3.17303261
76electron transport chain (GO:0022900)3.16318446
77negative regulation of protein activation cascade (GO:2000258)3.14244270
78mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.13049882
79leukocyte mediated cytotoxicity (GO:0001909)3.11541847
80positive regulation of triglyceride lipase activity (GO:0061365)3.09701516
81positive regulation of lipoprotein lipase activity (GO:0051006)3.09701516
82polyketide metabolic process (GO:0030638)3.07734477
83doxorubicin metabolic process (GO:0044598)3.07734477
84daunorubicin metabolic process (GO:0044597)3.07734477
85transcytosis (GO:0045056)3.06882734
86dendritic cell chemotaxis (GO:0002407)3.06465225
87regulation of T cell receptor signaling pathway (GO:0050856)3.05170034
88angiotensin maturation (GO:0002003)3.05081612
89plasma lipoprotein particle clearance (GO:0034381)3.04336928
90regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.03563819
91DNA deamination (GO:0045006)3.03401341
92positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.02633333
93megakaryocyte development (GO:0035855)3.02475400
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.00205201
95hepatocyte apoptotic process (GO:0097284)2.99292116
96negative T cell selection (GO:0043383)2.98129441
97reactive oxygen species biosynthetic process (GO:1903409)2.96402927
98ethanol metabolic process (GO:0006067)2.94483860
99regulation of B cell differentiation (GO:0045577)2.94269246
100regulation of respiratory burst (GO:0060263)2.92164366
101superoxide anion generation (GO:0042554)2.90819929
102regulation of gamma-delta T cell activation (GO:0046643)2.90487339
103fat-soluble vitamin biosynthetic process (GO:0042362)2.90173868
104granulocyte activation (GO:0036230)2.89411411
105uronic acid metabolic process (GO:0006063)2.89403830
106glucuronate metabolic process (GO:0019585)2.89403830
107negative regulation of sterol transport (GO:0032372)2.89024823
108negative regulation of cholesterol transport (GO:0032375)2.89024823
109acute-phase response (GO:0006953)2.86831226
110respiratory chain complex IV assembly (GO:0008535)2.85349122
111dendritic cell migration (GO:0036336)2.84253201
112negative regulation of complement activation (GO:0045916)2.83250057
113regulation of gamma-delta T cell differentiation (GO:0045586)2.83085298
114response to peptidoglycan (GO:0032494)2.82765617
115negative thymic T cell selection (GO:0045060)2.81952680
116leukocyte degranulation (GO:0043299)2.81704695
117cytochrome complex assembly (GO:0017004)2.80954661
118lipoprotein metabolic process (GO:0042157)2.80426448
119mast cell activation involved in immune response (GO:0002279)2.80408864
120mast cell degranulation (GO:0043303)2.80408864
121positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79988363
122regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.79690970
123cellular glucuronidation (GO:0052695)2.78513240
124bile acid metabolic process (GO:0008206)2.77618725
125urate metabolic process (GO:0046415)2.76704484
126regulation of oxidative phosphorylation (GO:0002082)2.76389996
127protein complex biogenesis (GO:0070271)2.74778004
128protein activation cascade (GO:0072376)2.74352588
129cellular response to interferon-beta (GO:0035458)2.74305446
130fibrinolysis (GO:0042730)2.74193960
131negative regulation of blood coagulation (GO:0030195)2.73807111
132negative regulation of hemostasis (GO:1900047)2.73807111
133response to type I interferon (GO:0034340)2.73431170
134lymphoid progenitor cell differentiation (GO:0002320)2.72995169
135oxaloacetate metabolic process (GO:0006107)2.72750833
136cholesterol homeostasis (GO:0042632)2.72698850
137angiogenesis involved in wound healing (GO:0060055)2.71542113
138negative regulation of coagulation (GO:0050819)2.71089436
139complement activation, classical pathway (GO:0006958)2.71074798
140fatty acid beta-oxidation (GO:0006635)2.70957159
141triglyceride homeostasis (GO:0070328)2.70825705
142acylglycerol homeostasis (GO:0055090)2.70825705
143positive regulation of granulocyte differentiation (GO:0030854)2.70790256
144viral transcription (GO:0019083)2.69269174
145regulation of chemokine biosynthetic process (GO:0045073)2.69226501
146cellular response to type I interferon (GO:0071357)2.68533154
147type I interferon signaling pathway (GO:0060337)2.68533154
148vitamin biosynthetic process (GO:0009110)2.67520246
149sterol homeostasis (GO:0055092)2.67419459
150aminoglycoside antibiotic metabolic process (GO:0030647)2.67094352
151necroptotic process (GO:0070266)2.66888310
152negative regulation of granulocyte differentiation (GO:0030853)2.66759860
153aerobic respiration (GO:0009060)2.66682611
154glycoside metabolic process (GO:0016137)2.66589855
155definitive hemopoiesis (GO:0060216)2.66240967
156* leukotriene metabolic process (GO:0006691)2.65687314
157regulation of alpha-beta T cell proliferation (GO:0046640)2.65503172
158sterol transport (GO:0015918)2.65168834
159cholesterol transport (GO:0030301)2.65168834
160fatty acid catabolic process (GO:0009062)2.63433057
161bile acid biosynthetic process (GO:0006699)2.63230946
162oligosaccharide catabolic process (GO:0009313)2.62562461
163leukocyte cell-cell adhesion (GO:0007159)2.62434973
164defense response to protozoan (GO:0042832)2.62357560
165cellular response to interleukin-15 (GO:0071350)2.61837487
166fructose metabolic process (GO:0006000)2.61805085
167positive regulation of alpha-beta T cell proliferation (GO:0046641)2.61107580
168response to protozoan (GO:0001562)2.60742490
169myeloid dendritic cell activation (GO:0001773)2.60668332
170T cell homeostasis (GO:0043029)2.58739987
171primary alcohol catabolic process (GO:0034310)2.58006351
172short-chain fatty acid metabolic process (GO:0046459)2.57957069
173mitochondrial respiratory chain complex assembly (GO:0033108)2.56915973
174glyoxylate metabolic process (GO:0046487)2.56229457
175diacylglycerol metabolic process (GO:0046339)2.55617546
176positive regulation of fatty acid biosynthetic process (GO:0045723)2.55029772
177aldehyde catabolic process (GO:0046185)2.55026717
178regulation of metalloenzyme activity (GO:0048552)2.54173400
179translational termination (GO:0006415)2.54070370
180SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.53240808
181detection of external biotic stimulus (GO:0098581)2.50827550
182response to interleukin-15 (GO:0070672)2.49150085
183actin nucleation (GO:0045010)2.48942549
184negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.47623888
185myeloid cell activation involved in immune response (GO:0002275)2.47050723
186interferon-gamma-mediated signaling pathway (GO:0060333)2.46994977
187mature B cell differentiation involved in immune response (GO:0002313)2.45671767
188regulation of response to interferon-gamma (GO:0060330)2.45598644
189glucose 6-phosphate metabolic process (GO:0051156)2.45294507
190ribosomal small subunit biogenesis (GO:0042274)2.45154792
191signal peptide processing (GO:0006465)2.44868151
192cotranslational protein targeting to membrane (GO:0006613)2.44633874
193regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.44592929
194regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.44501634
195B cell receptor signaling pathway (GO:0050853)2.44359111
196protein targeting to ER (GO:0045047)2.43758582
197maintenance of gastrointestinal epithelium (GO:0030277)2.43668250
198positive regulation of keratinocyte differentiation (GO:0045618)2.41744779
199L-fucose catabolic process (GO:0042355)2.40635904
200L-fucose metabolic process (GO:0042354)2.40635904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.30511496
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.79558161
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.69032751
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.00990001
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.90773558
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.68255988
7* PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.63181860
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.61949600
9RXR_22158963_ChIP-Seq_LIVER_Mouse3.52114746
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.45712623
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44567366
12EGR1_23403033_ChIP-Seq_LIVER_Mouse3.43180202
13BP1_19119308_ChIP-ChIP_Hs578T_Human3.41675003
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.33145638
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.18549466
16* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.11841002
17PPARA_22158963_ChIP-Seq_LIVER_Mouse3.08062577
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82094685
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.79227530
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.78521216
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.74724259
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.74219280
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70150785
24LXR_22158963_ChIP-Seq_LIVER_Mouse2.68370621
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.67772785
26SPI1_23547873_ChIP-Seq_NB4_Human2.50502858
27SCL_19346495_ChIP-Seq_HPC-7_Human2.50209172
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48738379
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.37892432
30* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37463945
31* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.34380857
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33570619
33IRF8_27001747_Chip-Seq_BMDM_Mouse2.33556656
34* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30186163
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20187377
36* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.17878625
37MYB_26560356_Chip-Seq_TH2_Human2.17864076
38VDR_21846776_ChIP-Seq_THP-1_Human2.15824727
39* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15260790
40RUNX_20019798_ChIP-Seq_JUKART_Human2.12197688
41RUNX1_22412390_ChIP-Seq_EML_Mouse2.05177482
42BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00869818
43VDR_24763502_ChIP-Seq_THP-1_Human1.92819252
44MYB_26560356_Chip-Seq_TH1_Human1.90856587
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.85614132
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84108931
47* GATA4_25053715_ChIP-Seq_YYC3_Human1.83103010
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83100975
49* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81371446
50* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.79685554
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78578393
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75303163
53* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72866746
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72348283
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71085191
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68762574
57MAF_26560356_Chip-Seq_TH1_Human1.66073491
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63130482
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.62765434
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.62367892
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57527181
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.55849495
63UTX_26944678_Chip-Seq_JUKART_Human1.54820278
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.53337793
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.51431611
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48065055
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42003451
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41733072
69* SOX2_20726797_ChIP-Seq_SW620_Human1.41594715
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40594968
71MYC_22102868_ChIP-Seq_BL_Human1.38924455
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38899511
73* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37678729
74PU_27001747_Chip-Seq_BMDM_Mouse1.36045245
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34846652
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.33020234
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29813561
78* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28285397
79FOXP3_21729870_ChIP-Seq_TREG_Human1.27615061
80* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27464574
81SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25110740
82GATA3_27048872_Chip-Seq_THYMUS_Human1.24485508
83CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23928341
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23514065
85EST1_17652178_ChIP-ChIP_JURKAT_Human1.23170973
86DCP1A_22483619_ChIP-Seq_HELA_Human1.22752914
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21622805
88AR_20517297_ChIP-Seq_VCAP_Human1.21507165
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21304349
90HTT_18923047_ChIP-ChIP_STHdh_Human1.20877976
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20479279
92VDR_23849224_ChIP-Seq_CD4+_Human1.19130614
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18483142
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.18059649
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17504480
96ZNF263_19887448_ChIP-Seq_K562_Human1.16130300
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15917875
98GATA3_26560356_Chip-Seq_TH2_Human1.15221571
99AR_21909140_ChIP-Seq_LNCAP_Human1.14796545
100* GATA6_25053715_ChIP-Seq_YYC3_Human1.14684012
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13519711
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12670407
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12208221
104FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11942346
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11237168
106FOXM1_23109430_ChIP-Seq_U2OS_Human1.11072510
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11038519
108KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10612369
109* SPI1_23127762_ChIP-Seq_K562_Human1.10104090
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09146066
111ELK1_19687146_ChIP-ChIP_HELA_Human1.08884060
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08840521
113BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.07849425
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07410486
115* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07407494
116FOXA2_19822575_ChIP-Seq_HepG2_Human1.07309997
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05844525
118GABP_17652178_ChIP-ChIP_JURKAT_Human1.03521926
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03517744
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02336259
121MAF_26560356_Chip-Seq_TH2_Human1.01280727
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00775514
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99652865
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99259951
125STAT1_20625510_ChIP-Seq_HELA_Human0.97551580
126RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96849730
127CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95869884
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95841680
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95678352
130E2F1_21310950_ChIP-Seq_MCF-7_Human0.95575646
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94826325
132GATA1_22025678_ChIP-Seq_K562_Human0.94269407
133PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93970289
134GABP_19822575_ChIP-Seq_HepG2_Human0.91558889
135ERG_20517297_ChIP-Seq_VCAP_Human0.91151728
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89964327
137TFEB_21752829_ChIP-Seq_HELA_Human0.88929187
138SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88627116
139CIITA_25753668_ChIP-Seq_RAJI_Human0.88610563
140TCF7_22412390_ChIP-Seq_EML_Mouse0.86688088
141SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86191638
142FOXA1_25329375_ChIP-Seq_VCAP_Human0.85975502
143FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85975502
144* CEBPB_22108803_ChIP-Seq_LS180_Human0.85554078
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.85342204
146PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84748085
147SRF_21415370_ChIP-Seq_HL-1_Mouse0.83710832
148STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83680041
149GATA3_24758297_ChIP-Seq_MCF-7_Human0.83545699
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83339802
151PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83233684
152PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83192661
153HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.82820842
154IRF1_19129219_ChIP-ChIP_H3396_Human0.82169423
155CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81827263
156MYC_19030024_ChIP-ChIP_MESCs_Mouse0.80993259
157MYC_18555785_ChIP-Seq_MESCs_Mouse0.80734202
158PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80552041
159PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78812263
160TP63_19390658_ChIP-ChIP_HaCaT_Human0.78702602
161GATA1_19941827_ChIP-Seq_MEL_Mouse0.78100722
162FLI1_27457419_Chip-Seq_LIVER_Mouse0.76684127
163SMAD_19615063_ChIP-ChIP_OVARY_Human0.74883286
164NFE2_27457419_Chip-Seq_LIVER_Mouse0.74621690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.96760620
2MP0005360_urolithiasis4.74981054
3MP0005365_abnormal_bile_salt4.44290969
4MP0003806_abnormal_nucleotide_metabolis4.22499920
5MP0002396_abnormal_hematopoietic_system3.94908683
6MP0001835_abnormal_antigen_presentation3.87570131
7MP0005085_abnormal_gallbladder_physiolo3.75141718
8MP0009785_altered_susceptibility_to3.69110171
9MP0003195_calcinosis3.38462921
10MP0003763_abnormal_thymus_physiology3.17191879
11MP0008875_abnormal_xenobiotic_pharmacok3.09760335
12MP0005671_abnormal_response_to3.03257174
13MP0002166_altered_tumor_susceptibility2.73393184
14MP0009840_abnormal_foam_cell2.70305034
15MP0005058_abnormal_lysosome_morphology2.67989423
16MP0005025_abnormal_response_to2.61229508
17MP0003436_decreased_susceptibility_to2.60396265
18MP0002148_abnormal_hypersensitivity_rea2.59344968
19MP0010329_abnormal_lipoprotein_level2.54161629
20MP0010155_abnormal_intestine_physiology2.51970235
21MP0002419_abnormal_innate_immunity2.49400171
22MP0005174_abnormal_tail_pigmentation2.43244463
23MP0001873_stomach_inflammation2.42563046
24MP0001800_abnormal_humoral_immune2.40237153
25MP0002420_abnormal_adaptive_immunity2.40132294
26MP0000490_abnormal_crypts_of2.37836663
27MP0005000_abnormal_immune_tolerance2.37153305
28MP0001819_abnormal_immune_cell2.36926176
29MP0002006_tumorigenesis2.36746118
30MP0003183_abnormal_peptide_metabolism2.33275559
31MP0002452_abnormal_antigen_presenting2.31172014
32MP0003724_increased_susceptibility_to2.28967973
33MP0002723_abnormal_immune_serum2.22192084
34MP0006036_abnormal_mitochondrial_physio2.20684286
35MP0000685_abnormal_immune_system2.16744074
36MP0005332_abnormal_amino_acid2.15896491
37MP0003866_abnormal_defecation2.09730871
38MP0002398_abnormal_bone_marrow2.09687366
39MP0001764_abnormal_homeostasis2.06345663
40MP0001790_abnormal_immune_system2.05967580
41MP0005387_immune_system_phenotype2.05967580
42MP0004019_abnormal_vitamin_homeostasis2.04354377
43MP0009333_abnormal_splenocyte_physiolog2.02207663
44MP0003252_abnormal_bile_duct2.00552771
45MP0008004_abnormal_stomach_pH1.97286083
46MP0002405_respiratory_system_inflammati1.94371598
47MP0005464_abnormal_platelet_physiology1.93253090
48MP0000716_abnormal_immune_system1.92017310
49MP0003718_maternal_effect1.90599245
50MP0004264_abnormal_extraembryonic_tissu1.90405792
51MP0005636_abnormal_mineral_homeostasis1.88189949
52MP0002009_preneoplasia1.85283867
53MP0002722_abnormal_immune_system1.71376937
54MP0001845_abnormal_inflammatory_respons1.67980065
55MP0002429_abnormal_blood_cell1.64945579
56MP0000689_abnormal_spleen_morphology1.64726425
57MP0004808_abnormal_hematopoietic_stem1.64612553
58MP0010234_abnormal_vibrissa_follicle1.63698051
59MP0002132_abnormal_respiratory_system1.62635612
60MP0005319_abnormal_enzyme/_coenzyme1.60147665
61MP0002118_abnormal_lipid_homeostasis1.58622930
62MP0003693_abnormal_embryo_hatching1.56646601
63MP0003868_abnormal_feces_composition1.56441418
64MP0009643_abnormal_urine_homeostasis1.55846657
65MP0000609_abnormal_liver_physiology1.55729526
66MP0002138_abnormal_hepatobiliary_system1.55539230
67MP0000858_altered_metastatic_potential1.54574117
68MP0005075_abnormal_melanosome_morpholog1.49511358
69MP0001663_abnormal_digestive_system1.48718160
70MP0005084_abnormal_gallbladder_morpholo1.44889233
71MP0000703_abnormal_thymus_morphology1.44531639
72MP0000465_gastrointestinal_hemorrhage1.43879666
73MP0002095_abnormal_skin_pigmentation1.42054198
74MP0000015_abnormal_ear_pigmentation1.41196527
75MP0001545_abnormal_hematopoietic_system1.40922079
76MP0005397_hematopoietic_system_phenotyp1.40922079
77MP0010094_abnormal_chromosome_stability1.39632804
78MP0005670_abnormal_white_adipose1.35878123
79MP0003075_altered_response_to1.34611584
80MP0000343_altered_response_to1.32394854
81MP0002876_abnormal_thyroid_physiology1.32181565
82MP0003300_gastrointestinal_ulcer1.31135544
83MP0001853_heart_inflammation1.30931932
84MP0005408_hypopigmentation1.30679925
85MP0002837_dystrophic_cardiac_calcinosis1.29061078
86MP0004947_skin_inflammation1.26865861
87MP0006082_CNS_inflammation1.23972790
88MP0003656_abnormal_erythrocyte_physiolo1.21258401
89MP0002277_abnormal_respiratory_mucosa1.21146928
90MP0001756_abnormal_urination1.20489014
91MP0005584_abnormal_enzyme/coenzyme_acti1.18241276
92MP0006054_spinal_hemorrhage1.17629716
93MP0004782_abnormal_surfactant_physiolog1.17104380
94MP0009697_abnormal_copulation1.16084792
95MP0008469_abnormal_protein_level1.13278328
96MP0001188_hyperpigmentation1.12757629
97MP0005330_cardiomyopathy1.12109433
98MP0005165_increased_susceptibility_to1.11906177
99MP0005409_darkened_coat_color1.11714285
100MP0001533_abnormal_skeleton_physiology1.08962886
101MP0010368_abnormal_lymphatic_system1.08308840
102MP0008057_abnormal_DNA_replication1.08276209
103MP0002019_abnormal_tumor_incidence1.07661801
104MP0005410_abnormal_fertilization1.06003068
105MP0004043_abnormal_pH_regulation1.05781837
106MP0005167_abnormal_blood-brain_barrier1.05726820
107MP0000477_abnormal_intestine_morphology1.02925828
108MP0003303_peritoneal_inflammation1.01908181
109MP0001986_abnormal_taste_sensitivity1.01619518
110MP0004147_increased_porphyrin_level1.00392671
111MP0001661_extended_life_span0.99135463
112MP0001666_abnormal_nutrient_absorption0.98860339
113MP0005381_digestive/alimentary_phenotyp0.97915390
114MP0000470_abnormal_stomach_morphology0.96747511
115MP0005166_decreased_susceptibility_to0.96218043
116MP0003111_abnormal_nucleus_morphology0.96170456
117MP0004381_abnormal_hair_follicle0.95588981
118MP0002933_joint_inflammation0.95285817
119MP0005310_abnormal_salivary_gland0.94345225
120MP0003172_abnormal_lysosome_physiology0.94233162
121MP0005451_abnormal_body_composition0.93450936
122MP0005376_homeostasis/metabolism_phenot0.91841488
123MP0009642_abnormal_blood_homeostasis0.91724884
124MP0000598_abnormal_liver_morphology0.91338473
125MP0003011_delayed_dark_adaptation0.91085284
126MP0001664_abnormal_digestion0.90986182
127MP0009764_decreased_sensitivity_to0.90148172
128MP0003950_abnormal_plasma_membrane0.87954846
129MP0010352_gastrointestinal_tract_polyps0.86808619
130MP0008058_abnormal_DNA_repair0.86713718
131MP0003077_abnormal_cell_cycle0.84826676
132MP0002078_abnormal_glucose_homeostasis0.84553527
133MP0000372_irregular_coat_pigmentation0.83755879
134MP0005395_other_phenotype0.83046169
135MP0008007_abnormal_cellular_replicative0.81249501
136MP0001765_abnormal_ion_homeostasis0.80195310
137MP0000569_abnormal_digit_pigmentation0.79369476
138MP0005448_abnormal_energy_balance0.78466383
139MP0005535_abnormal_body_temperature0.77586204
140MP0000516_abnormal_urinary_system0.76969404
141MP0005367_renal/urinary_system_phenotyp0.76969404
142MP0003638_abnormal_response/metabolism_0.73144386
143MP0005266_abnormal_metabolism0.73015605
144MP0002971_abnormal_brown_adipose0.71613179
145MP0009278_abnormal_bone_marrow0.71426200
146MP0006035_abnormal_mitochondrial_morpho0.70426675
147MP0003448_altered_tumor_morphology0.69429239
148MP0004215_abnormal_myocardial_fiber0.68957765
149MP0003186_abnormal_redox_activity0.68195041
150MP0001881_abnormal_mammary_gland0.67557391
151MP0002136_abnormal_kidney_physiology0.67132197
152MP0002693_abnormal_pancreas_physiology0.66435898
153MP0009379_abnormal_foot_pigmentation0.64437052
154MP0005220_abnormal_exocrine_pancreas0.63988459
155MP0005647_abnormal_sex_gland0.61901117
156MP0008872_abnormal_physiological_respon0.61648915
157MP0010307_abnormal_tumor_latency0.61070777
158MP0002877_abnormal_melanocyte_morpholog0.60644620
159MP0003786_premature_aging0.60393031
160MP0009765_abnormal_xenobiotic_induced0.59449288
161MP0001216_abnormal_epidermal_layer0.59422138
162MP0004957_abnormal_blastocyst_morpholog0.59255827
163MP0003953_abnormal_hormone_level0.59238492
164MP0009763_increased_sensitivity_to0.59064268
165MP0003191_abnormal_cellular_cholesterol0.58164749
166MP0000313_abnormal_cell_death0.56867246

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.33294366
2Recurrent abscess formation (HP:0002722)5.03889955
3Thrombocytosis (HP:0001894)4.94154645
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.87588938
5Recurrent bacterial skin infections (HP:0005406)4.40408354
6Prolonged partial thromboplastin time (HP:0003645)4.34449595
7Systemic lupus erythematosus (HP:0002725)4.31799031
8Chronic otitis media (HP:0000389)4.30351354
9Hypobetalipoproteinemia (HP:0003563)4.21015737
10Complement deficiency (HP:0004431)4.17915478
11Myositis (HP:0100614)4.16111274
12Deep venous thrombosis (HP:0002625)4.08516100
13Abnormality of B cell number (HP:0010975)4.00248002
14B lymphocytopenia (HP:0010976)4.00248002
15Hypoglycemic coma (HP:0001325)3.84890601
16Chronic obstructive pulmonary disease (HP:0006510)3.83889532
17Obstructive lung disease (HP:0006536)3.83889532
18Elevated erythrocyte sedimentation rate (HP:0003565)3.83749526
19Recurrent fungal infections (HP:0002841)3.71795120
20Glomerulonephritis (HP:0000099)3.61243903
21Pustule (HP:0200039)3.60618042
22Abnormality of monocarboxylic acid metabolism (HP:0010996)3.57624319
23Autoimmune thrombocytopenia (HP:0001973)3.57198691
24Periodontitis (HP:0000704)3.54662606
25Severe combined immunodeficiency (HP:0004430)3.52885542
26Eosinophilia (HP:0001880)3.49159511
27Meningitis (HP:0001287)3.40410597
28Abnormality of eosinophils (HP:0001879)3.33479680
29Hepatic necrosis (HP:0002605)3.33254582
30Granulocytopenia (HP:0001913)3.30733088
31Recurrent viral infections (HP:0004429)3.29821826
32Hypoglycemic seizures (HP:0002173)3.24416569
33Acute encephalopathy (HP:0006846)3.18089464
34IgM deficiency (HP:0002850)3.17629675
35Combined immunodeficiency (HP:0005387)3.17628491
36Abnormality of complement system (HP:0005339)3.17089864
37Autoimmune hemolytic anemia (HP:0001890)3.14114244
38Thyroiditis (HP:0100646)3.13889970
39Abnormality of T cells (HP:0002843)3.13704083
40T lymphocytopenia (HP:0005403)3.10279502
41Acute necrotizing encephalopathy (HP:0006965)3.08794011
42Abnormality of the prostate (HP:0008775)3.07571413
43Abnormality of T cell number (HP:0011839)3.06265262
44Recurrent skin infections (HP:0001581)2.99817762
45Abnormality of urine glucose concentration (HP:0011016)2.98540938
46Glycosuria (HP:0003076)2.98540938
47Joint hemorrhage (HP:0005261)2.97927178
48Abnormal mitochondria in muscle tissue (HP:0008316)2.97083004
49Mitochondrial inheritance (HP:0001427)2.96554884
50Generalized aminoaciduria (HP:0002909)2.94277374
51Poikiloderma (HP:0001029)2.94010851
52Hepatocellular necrosis (HP:0001404)2.93881645
53Abnormality of T cell physiology (HP:0011840)2.93293929
54Fat malabsorption (HP:0002630)2.90951108
55Chronic diarrhea (HP:0002028)2.90876400
56Reticulocytopenia (HP:0001896)2.90287879
57Increased serum pyruvate (HP:0003542)2.88358697
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.88285419
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.85649084
60Dicarboxylic aciduria (HP:0003215)2.85649084
61Mediastinal lymphadenopathy (HP:0100721)2.83814995
62Intrahepatic cholestasis (HP:0001406)2.83747920
63Orchitis (HP:0100796)2.82577463
64Gingivitis (HP:0000230)2.82317585
65Abnormality of glutamine family amino acid metabolism (HP:0010902)2.82301664
66Optic neuritis (HP:0100653)2.81741677
67Retrobulbar optic neuritis (HP:0100654)2.81741677
68Recurrent bronchitis (HP:0002837)2.81686441
69Panhypogammaglobulinemia (HP:0003139)2.81360691
70Nausea (HP:0002018)2.79705156
71Increased CSF lactate (HP:0002490)2.78737928
72Chronic mucocutaneous candidiasis (HP:0002728)2.78194056
73Recurrent cutaneous fungal infections (HP:0011370)2.78194056
74Cheilitis (HP:0100825)2.75965482
75Hyperammonemia (HP:0001987)2.74761505
76Recurrent gram-negative bacterial infections (HP:0005420)2.73706368
77Xanthomatosis (HP:0000991)2.71764163
78Cerebral edema (HP:0002181)2.68840870
79Hyperinsulinemic hypoglycemia (HP:0000825)2.67533404
80Recurrent pneumonia (HP:0006532)2.65863105
81Symptomatic seizures (HP:0011145)2.65582105
82Vasculitis (HP:0002633)2.64886902
83Leukocytosis (HP:0001974)2.64171766
84Lymphopenia (HP:0001888)2.63255067
85Petechiae (HP:0000967)2.62839870
86Abnormal number of erythroid precursors (HP:0012131)2.60037194
87Hypolipoproteinemia (HP:0010981)2.59167771
88Abnormality of cells of the lymphoid lineage (HP:0012140)2.58583754
89Progressive macrocephaly (HP:0004481)2.57889132
90Prolonged bleeding time (HP:0003010)2.54881680
91Hypergammaglobulinemia (HP:0010702)2.54312674
92Abnormality of the fingertips (HP:0001211)2.52925509
93Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52601394
94Acanthocytosis (HP:0001927)2.50346747
95Abnormality of macrophages (HP:0004311)2.48145862
96Sepsis (HP:0100806)2.47372182
97Stomatitis (HP:0010280)2.47263505
98Abnormality of cells of the erythroid lineage (HP:0012130)2.47246956
99Reduced antithrombin III activity (HP:0001976)2.46868666
100Abnormality of glycolysis (HP:0004366)2.46622626
101Cellulitis (HP:0100658)2.44580387
102Encephalitis (HP:0002383)2.43890800
103Lethargy (HP:0001254)2.43439714
104Type I transferrin isoform profile (HP:0003642)2.41187543
105Increased hepatocellular lipid droplets (HP:0006565)2.40365146
106Vascular calcification (HP:0004934)2.39987198
107Lipid accumulation in hepatocytes (HP:0006561)2.38862205
108IgG deficiency (HP:0004315)2.38849576
109Pancreatic islet-cell hyperplasia (HP:0004510)2.38355162
110Abnormality of methionine metabolism (HP:0010901)2.36956317
111Steatorrhea (HP:0002570)2.36863688
112Agammaglobulinemia (HP:0004432)2.35976969
113Chromsome breakage (HP:0040012)2.35097918
114Renal Fanconi syndrome (HP:0001994)2.33313336
115Ketoacidosis (HP:0001993)2.30701985
116Increased intramyocellular lipid droplets (HP:0012240)2.30287158
117Increased IgE level (HP:0003212)2.29846450
118Recurrent sinusitis (HP:0011108)2.29739698
119Abnormality of the common coagulation pathway (HP:0010990)2.29710599
120Inflammation of the large intestine (HP:0002037)2.29372686
121Malnutrition (HP:0004395)2.27377773
122Hemoptysis (HP:0002105)2.27224319
123Abnormality of vitamin metabolism (HP:0100508)2.22756234
124Lymphoma (HP:0002665)2.22728519
125Recurrent lower respiratory tract infections (HP:0002783)2.22246443
126Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21860694
127Osteomyelitis (HP:0002754)2.21554869
128Increased muscle lipid content (HP:0009058)2.21343817
129Acute myeloid leukemia (HP:0004808)2.20967981
130Spontaneous abortion (HP:0005268)2.19825607
131Hypoplasia of the thymus (HP:0000778)2.19769387
132Metabolic acidosis (HP:0001942)2.19757363
133Keratoconjunctivitis sicca (HP:0001097)2.19710695
134Urticaria (HP:0001025)2.19569740
135Abnormality of glycolipid metabolism (HP:0010969)2.19461309
136Abnormality of liposaccharide metabolism (HP:0010968)2.19461309
137Abnormality of glycosphingolipid metabolism (HP:0004343)2.19461309
138Cerebral palsy (HP:0100021)2.18834664
139Amyloidosis (HP:0011034)2.18483293
140Lactic acidosis (HP:0003128)2.18471748
141Skin ulcer (HP:0200042)2.18068298
142Abnormality of vitamin B metabolism (HP:0004340)2.17360432
143Epistaxis (HP:0000421)2.16604601
144Renal cortical cysts (HP:0000803)2.15705677
145Hyperphosphaturia (HP:0003109)2.14414198
146Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13397482
147Ketosis (HP:0001946)2.12922600
148Respiratory failure (HP:0002878)2.12646673
149Purpura (HP:0000979)2.12578627
150Hypothermia (HP:0002045)2.11828173
151Gastrointestinal inflammation (HP:0004386)2.11391294
152Neutropenia (HP:0001875)2.11353179
153Chronic sinusitis (HP:0011109)2.10080585
154Acute lymphatic leukemia (HP:0006721)2.07729232
155Aplasia/Hypoplasia of the thymus (HP:0010515)2.07136914
156Rhabdomyolysis (HP:0003201)2.06755362
157Prostate neoplasm (HP:0100787)2.05480972
158Abnormality of fatty-acid metabolism (HP:0004359)2.05246383
159Methylmalonic aciduria (HP:0012120)2.05151208
160Pulmonary infiltrates (HP:0002113)2.05017165
161Nephritis (HP:0000123)2.03903268
162Abnormality of the preputium (HP:0100587)2.03470160
163Palpitations (HP:0001962)2.02851898
164Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01944125
165Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01944125
166Clubbing of toes (HP:0100760)2.01226957
167Chest pain (HP:0100749)2.00350940
168Abnormality of DNA repair (HP:0003254)2.00328566
1693-Methylglutaconic aciduria (HP:0003535)2.00201276
170Vacuolated lymphocytes (HP:0001922)1.99254337
171Keratoconjunctivitis (HP:0001096)1.98706119
172Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98534327
173Abnormal protein N-linked glycosylation (HP:0012347)1.98534327
174Abnormal protein glycosylation (HP:0012346)1.98534327
175Abnormal glycosylation (HP:0012345)1.98534327
176Proximal tubulopathy (HP:0000114)1.98403699
177Conjugated hyperbilirubinemia (HP:0002908)1.98375398
178Hyperglycinemia (HP:0002154)1.97704175
179Abnormality of the vitamin B12 metabolism (HP:0004341)1.97340668
180Increased IgM level (HP:0003496)1.97228678
181Hydroxyprolinuria (HP:0003080)1.95809080
182Abnormality of proline metabolism (HP:0010907)1.95809080
183CNS demyelination (HP:0007305)1.95705397
184Delayed CNS myelination (HP:0002188)1.92059278
185Hemorrhage of the eye (HP:0011885)1.91072164
186Increased serum lactate (HP:0002151)1.90275405
187Cardiovascular calcification (HP:0011915)1.89949090
188Methylmalonic acidemia (HP:0002912)1.88252721
189Hyperglycinuria (HP:0003108)1.87898442
190Abnormality of serine family amino acid metabolism (HP:0010894)1.85755637
191Abnormality of glycine metabolism (HP:0010895)1.85755637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.03862728
2MAP4K13.81108564
3IRAK43.60010402
4INSRR3.50103756
5PDK23.47110601
6VRK22.92334906
7KIT2.91671539
8TEC2.44894678
9FLT32.37472664
10BLK2.34908518
11ZAP702.25264013
12EIF2AK32.24889923
13IKBKE2.21674988
14EIF2AK12.14530403
15MST42.11866508
16BCKDK2.10081530
17STK161.98518210
18ARAF1.97200218
19MAP4K21.96208830
20TYK21.96000411
21MAP3K141.94453483
22BTK1.94074997
23JAK31.80368191
24ADRBK21.80246352
25TESK21.78243877
26IRAK31.78047308
27NME21.70692470
28GRK61.69387803
29CLK11.65990022
30VRK11.59911342
31PBK1.55726845
32TIE11.53523995
33TAOK31.49962129
34ITK1.48416281
35EEF2K1.46563650
36FER1.45663945
37STK101.42640206
38MAP3K121.41914263
39CSF1R1.41135025
40SYK1.36254205
41RIPK41.35022125
42MAP2K31.34237998
43TNK21.32098741
44FRK1.31430419
45LCK1.28588228
46ABL21.27337617
47OBSCN1.24379240
48TBK11.24239436
49KDR1.23222903
50PIM21.23041040
51TGFBR21.22634785
52YES11.21286791
53EPHA21.17391315
54MAP2K61.16929322
55STK391.16520881
56NUAK11.13951345
57TESK11.10333017
58NEK11.10075599
59JAK11.09786150
60LYN1.09193160
61TRPM71.08046485
62HCK1.07881925
63NME11.06108678
64IKBKB1.03094462
65PRKAA21.02193785
66BRD41.01666222
67OXSR11.00970621
68MATK1.00634013
69PIM10.97795739
70PASK0.96225322
71MAP3K30.93917703
72SCYL20.93148605
73ZAK0.92418612
74NLK0.92333956
75FES0.92264305
76CSK0.91895262
77SIK30.91403652
78PRKG20.89809225
79WNK40.87698726
80GRK10.86014872
81ILK0.85515970
82MYLK0.82281142
83DAPK10.82001218
84FGFR30.81909014
85MKNK10.81379854
86SRPK10.79979610
87PIK3CA0.79121702
88MKNK20.78845500
89ERN10.78334403
90STK40.76996940
91EIF2AK20.76587541
92MAPKAPK30.75081564
93CHUK0.74623643
94LRRK20.73904641
95PHKG20.72541082
96PHKG10.72541082
97MST1R0.72499327
98RPS6KL10.71824490
99RPS6KC10.71824490
100RPS6KA60.69940889
101MAP3K60.69359043
102MAP3K20.68519142
103RPS6KA40.65762721
104PDPK10.63708491
105RPS6KB20.62615708
106TNIK0.62525679
107PKN20.62453982
108MAPKAPK50.60783990
109FGFR40.60721530
110ATR0.60483514
111ERBB40.59187734
112PIK3CG0.59142002
113HIPK20.58772034
114CDK70.57849256
115CSNK2A20.57154710
116MAPK40.56737209
117STK240.56207527
118BMPR1B0.54611017
119RPS6KB10.53095128
120MAP3K110.52886816
121MAPK110.52883385
122PRKCD0.52824850
123RPS6KA20.52295807
124MAP3K130.52202946
125PRPF4B0.49784048
126MAP3K80.49775469
127CDK60.49720768
128MAP3K100.49120334
129ACVR1B0.47042688
130CSNK2A10.46591532
131CDK80.45954601
132MAPKAPK20.45208600
133ERBB30.44556577
134CDC70.44158214
135GRK70.43825200
136DAPK30.42767532
137IGF1R0.41755664
138PDK10.41753530
139PRKCI0.41575910
140PRKACG0.40263913
141PRKCQ0.38616571
142EPHB10.38597096
143LMTK20.38480101
144BRSK20.38457710
145TGFBR10.37806740
146CDK90.37458253
147TLK10.37349591
148BMPR20.37045998
149MAP3K10.36218704
150AKT30.36215334
151PAK40.35745598
152TAOK20.32705448
153PRKCA0.31475001
154CSNK1G30.31215389

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.57930030
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.40229740
3Complement and coagulation cascades_Homo sapiens_hsa046102.50044225
4Leishmaniasis_Homo sapiens_hsa051402.48695434
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.43897677
6Ribosome_Homo sapiens_hsa030102.32037589
7DNA replication_Homo sapiens_hsa030302.30016066
8Fatty acid degradation_Homo sapiens_hsa000712.25683879
9Oxidative phosphorylation_Homo sapiens_hsa001902.25522259
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18880115
11Homologous recombination_Homo sapiens_hsa034402.18341757
12Hematopoietic cell lineage_Homo sapiens_hsa046402.13186826
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.12748602
14* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08860783
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07598177
16Caffeine metabolism_Homo sapiens_hsa002322.06281898
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05056013
18Primary bile acid biosynthesis_Homo sapiens_hsa001202.02070065
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01660166
20* Chemical carcinogenesis_Homo sapiens_hsa052041.99893363
21* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96548606
22Measles_Homo sapiens_hsa051621.95658621
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.91352872
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.82892675
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.82439371
26Retinol metabolism_Homo sapiens_hsa008301.82061831
27Fatty acid elongation_Homo sapiens_hsa000621.81795619
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80349914
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80048150
30Fanconi anemia pathway_Homo sapiens_hsa034601.79051841
31Arginine biosynthesis_Homo sapiens_hsa002201.74981543
32Mismatch repair_Homo sapiens_hsa034301.73823197
33Non-homologous end-joining_Homo sapiens_hsa034501.70941286
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.70657324
35Parkinsons disease_Homo sapiens_hsa050121.69406505
36Herpes simplex infection_Homo sapiens_hsa051681.69193327
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68808356
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66043816
39Base excision repair_Homo sapiens_hsa034101.65963691
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63807897
41Proteasome_Homo sapiens_hsa030501.63044102
42Propanoate metabolism_Homo sapiens_hsa006401.60999823
43Peroxisome_Homo sapiens_hsa041461.60653090
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59612552
45Allograft rejection_Homo sapiens_hsa053301.56237293
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.55704877
47Tryptophan metabolism_Homo sapiens_hsa003801.54625577
48Fatty acid metabolism_Homo sapiens_hsa012121.53412379
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52683320
50Phenylalanine metabolism_Homo sapiens_hsa003601.52232213
51Graft-versus-host disease_Homo sapiens_hsa053321.48465169
52Osteoclast differentiation_Homo sapiens_hsa043801.47844665
53PPAR signaling pathway_Homo sapiens_hsa033201.46228061
54Butanoate metabolism_Homo sapiens_hsa006501.46032411
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44833440
56Pentose phosphate pathway_Homo sapiens_hsa000301.40775567
57Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39908072
58Tyrosine metabolism_Homo sapiens_hsa003501.39506162
59Antigen processing and presentation_Homo sapiens_hsa046121.35735021
60Pyruvate metabolism_Homo sapiens_hsa006201.29993021
61Jak-STAT signaling pathway_Homo sapiens_hsa046301.29762578
62Legionellosis_Homo sapiens_hsa051341.27970995
63Other glycan degradation_Homo sapiens_hsa005111.26965321
64Leukocyte transendothelial migration_Homo sapiens_hsa046701.26671310
65T cell receptor signaling pathway_Homo sapiens_hsa046601.25383320
66Cyanoamino acid metabolism_Homo sapiens_hsa004601.23657169
67Influenza A_Homo sapiens_hsa051641.23239810
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22501945
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15084507
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12944866
71Protein export_Homo sapiens_hsa030601.11731118
72Galactose metabolism_Homo sapiens_hsa000521.10862054
73Alzheimers disease_Homo sapiens_hsa050101.10696793
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08738605
75Carbon metabolism_Homo sapiens_hsa012001.08708885
76Folate biosynthesis_Homo sapiens_hsa007901.05994898
77Pertussis_Homo sapiens_hsa051331.05221272
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04289314
79Glycosaminoglycan degradation_Homo sapiens_hsa005311.03448464
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03274361
81Arginine and proline metabolism_Homo sapiens_hsa003301.02986683
82Nucleotide excision repair_Homo sapiens_hsa034201.02734192
83Tuberculosis_Homo sapiens_hsa051521.01024242
84Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00202704
85B cell receptor signaling pathway_Homo sapiens_hsa046620.99682683
86Huntingtons disease_Homo sapiens_hsa050160.98831112
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97406643
88Renin-angiotensin system_Homo sapiens_hsa046140.94158479
89Toxoplasmosis_Homo sapiens_hsa051450.93895788
90Salmonella infection_Homo sapiens_hsa051320.92436764
91Vitamin digestion and absorption_Homo sapiens_hsa049770.92414077
92Pyrimidine metabolism_Homo sapiens_hsa002400.92193358
93Hepatitis B_Homo sapiens_hsa051610.89761231
94Autoimmune thyroid disease_Homo sapiens_hsa053200.87979457
95Linoleic acid metabolism_Homo sapiens_hsa005910.87661476
96Hepatitis C_Homo sapiens_hsa051600.86761781
97Sphingolipid metabolism_Homo sapiens_hsa006000.86188118
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84839735
99Metabolic pathways_Homo sapiens_hsa011000.83808755
100Fructose and mannose metabolism_Homo sapiens_hsa000510.83574865
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82721581
102Acute myeloid leukemia_Homo sapiens_hsa052210.82209974
103TNF signaling pathway_Homo sapiens_hsa046680.81515089
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81514182
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80525277
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79739625
107Malaria_Homo sapiens_hsa051440.78401603
108beta-Alanine metabolism_Homo sapiens_hsa004100.78373822
109Arachidonic acid metabolism_Homo sapiens_hsa005900.77749173
110RNA degradation_Homo sapiens_hsa030180.77472384
111Cell cycle_Homo sapiens_hsa041100.76591171
112Apoptosis_Homo sapiens_hsa042100.76440105
113p53 signaling pathway_Homo sapiens_hsa041150.76309622
114Spliceosome_Homo sapiens_hsa030400.76272633
115RNA polymerase_Homo sapiens_hsa030200.75549870
116N-Glycan biosynthesis_Homo sapiens_hsa005100.75219222
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75165408
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74250155
119Chemokine signaling pathway_Homo sapiens_hsa040620.73356655
120Fat digestion and absorption_Homo sapiens_hsa049750.72734043
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72453919
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.70716729
123Sulfur metabolism_Homo sapiens_hsa009200.69814595
124Shigellosis_Homo sapiens_hsa051310.68363833
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68320127
126Starch and sucrose metabolism_Homo sapiens_hsa005000.68214753
127Sulfur relay system_Homo sapiens_hsa041220.68149219
128Asthma_Homo sapiens_hsa053100.67357867
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66446771
130Mineral absorption_Homo sapiens_hsa049780.66087754
131African trypanosomiasis_Homo sapiens_hsa051430.65732667
132Lysosome_Homo sapiens_hsa041420.64923557
133Rheumatoid arthritis_Homo sapiens_hsa053230.61520034
134ABC transporters_Homo sapiens_hsa020100.61263454
135Platelet activation_Homo sapiens_hsa046110.60889446
136Glycerolipid metabolism_Homo sapiens_hsa005610.60590388
137Bile secretion_Homo sapiens_hsa049760.60433825
138Viral myocarditis_Homo sapiens_hsa054160.59844855
139Steroid biosynthesis_Homo sapiens_hsa001000.57803294
140Purine metabolism_Homo sapiens_hsa002300.55992952
141Nitrogen metabolism_Homo sapiens_hsa009100.55481136
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52855331
143Histidine metabolism_Homo sapiens_hsa003400.52732752
144Fatty acid biosynthesis_Homo sapiens_hsa000610.52245206
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52052849
146Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52030991
147* Glutathione metabolism_Homo sapiens_hsa004800.51652619
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50153113
149Type I diabetes mellitus_Homo sapiens_hsa049400.50050066
150One carbon pool by folate_Homo sapiens_hsa006700.49806464
151Biosynthesis of amino acids_Homo sapiens_hsa012300.49744519
152Collecting duct acid secretion_Homo sapiens_hsa049660.49733119
153Thyroid cancer_Homo sapiens_hsa052160.47333982
154Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46950099
155Epstein-Barr virus infection_Homo sapiens_hsa051690.45810150
156Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44977525
157SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43049642
158Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42369050
159Staphylococcus aureus infection_Homo sapiens_hsa051500.42151361
160Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41611372
161HTLV-I infection_Homo sapiens_hsa051660.41243995
162Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40649759
163Cardiac muscle contraction_Homo sapiens_hsa042600.39297153
164Viral carcinogenesis_Homo sapiens_hsa052030.39104866
165Basal transcription factors_Homo sapiens_hsa030220.35387726
166Ether lipid metabolism_Homo sapiens_hsa005650.34004684

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