MGST3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.90284189
2ATP synthesis coupled proton transport (GO:0015986)7.34381643
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.34381643
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.97316142
5respiratory electron transport chain (GO:0022904)6.38616077
6electron transport chain (GO:0022900)6.25287865
7ATP biosynthetic process (GO:0006754)4.42511471
8hydrogen ion transmembrane transport (GO:1902600)4.38754816
9tricarboxylic acid cycle (GO:0006099)4.20083018
10protein neddylation (GO:0045116)4.06676275
11chaperone-mediated protein transport (GO:0072321)4.04616020
12NADH metabolic process (GO:0006734)4.04139876
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.94161418
14energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.92939858
15ATP hydrolysis coupled proton transport (GO:0015991)3.92939858
16proton transport (GO:0015992)3.85835808
17hydrogen transport (GO:0006818)3.80138950
18purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.79109885
19protein complex biogenesis (GO:0070271)3.73385443
20purine nucleoside triphosphate biosynthetic process (GO:0009145)3.72992412
21oxidative phosphorylation (GO:0006119)3.69854372
22inner mitochondrial membrane organization (GO:0007007)3.56110408
23protoporphyrinogen IX metabolic process (GO:0046501)3.55236424
24protoporphyrinogen IX biosynthetic process (GO:0006782)3.55117103
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.46689597
26NADH dehydrogenase complex assembly (GO:0010257)3.46689597
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.46689597
28regulation of acyl-CoA biosynthetic process (GO:0050812)3.43559804
29respiratory chain complex IV assembly (GO:0008535)3.36421823
30mitochondrial respiratory chain complex assembly (GO:0033108)3.29646336
31regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.25117796
32ribonucleoside triphosphate biosynthetic process (GO:0009201)3.22955491
33viral transcription (GO:0019083)3.21994665
34regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.21403019
35sarcomere organization (GO:0045214)3.19942968
36regulation of cell communication by electrical coupling (GO:0010649)3.18000998
37regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.17257998
38detection of calcium ion (GO:0005513)3.17097357
39sequestering of actin monomers (GO:0042989)3.14800610
40translational termination (GO:0006415)3.14606699
41response to methylmercury (GO:0051597)3.12842415
42calcium-mediated signaling using intracellular calcium source (GO:0035584)3.12410582
43cytochrome complex assembly (GO:0017004)3.09061610
44water-soluble vitamin biosynthetic process (GO:0042364)3.08695034
45regulation of coenzyme metabolic process (GO:0051196)3.07927019
46regulation of cofactor metabolic process (GO:0051193)3.07927019
47cotranslational protein targeting to membrane (GO:0006613)3.07872470
48proteasome assembly (GO:0043248)3.05241223
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04309060
50protein targeting to ER (GO:0045047)3.03417113
51heme biosynthetic process (GO:0006783)3.01941726
52positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.98634552
53transferrin transport (GO:0033572)2.96782264
54regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.95030733
55fatty acid elongation (GO:0030497)2.94551595
56protein localization to endoplasmic reticulum (GO:0070972)2.94304939
57establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94207685
58regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.94146434
59platelet dense granule organization (GO:0060155)2.93421522
60regulation of oxidative phosphorylation (GO:0002082)2.92446012
61porphyrin-containing compound biosynthetic process (GO:0006779)2.90532452
62negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.87796498
63synaptic vesicle exocytosis (GO:0016079)2.85152782
64negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.84330916
65vocalization behavior (GO:0071625)2.82220202
66nucleoside triphosphate biosynthetic process (GO:0009142)2.77744587
67neuronal action potential propagation (GO:0019227)2.77365836
68ferric iron transport (GO:0015682)2.76672335
69trivalent inorganic cation transport (GO:0072512)2.76672335
70ventricular cardiac muscle cell action potential (GO:0086005)2.75319629
71neuron cell-cell adhesion (GO:0007158)2.75258153
72behavioral response to nicotine (GO:0035095)2.75250805
73tetrapyrrole biosynthetic process (GO:0033014)2.71730565
74negative regulation of microtubule polymerization (GO:0031115)2.70567449
75bundle of His cell to Purkinje myocyte communication (GO:0086069)2.69762964
76generation of precursor metabolites and energy (GO:0006091)2.68748338
77negative regulation of protein localization to cell surface (GO:2000009)2.65092841
78intracellular protein transmembrane import (GO:0044743)2.63504102
79response to redox state (GO:0051775)2.61068480
80cellular response to epinephrine stimulus (GO:0071872)2.60552484
81regulation of mitochondrial translation (GO:0070129)2.59420727
82succinate metabolic process (GO:0006105)2.56330237
83response to epinephrine (GO:0071871)2.54392812
84regulation of relaxation of muscle (GO:1901077)2.52731566
85cellular ketone body metabolic process (GO:0046950)2.52334623
86negative regulation of response to food (GO:0032096)2.50652328
87negative regulation of appetite (GO:0032099)2.50652328
88translational elongation (GO:0006414)2.50500021
89cell communication involved in cardiac conduction (GO:0086065)2.49934201
90heart process (GO:0003015)2.49598684
91heart contraction (GO:0060047)2.49598684
92long-chain fatty acid biosynthetic process (GO:0042759)2.48215199
93regulation of actin filament-based movement (GO:1903115)2.47622555
94membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45071268
95regulation of heart rate by cardiac conduction (GO:0086091)2.44993355
96muscle filament sliding (GO:0030049)2.44249665
97actin-myosin filament sliding (GO:0033275)2.44249665
98sarcoplasmic reticulum calcium ion transport (GO:0070296)2.44176345
99response to insecticide (GO:0017085)2.43902439
100aerobic respiration (GO:0009060)2.43674186
101heme metabolic process (GO:0042168)2.43470100
102transcription elongation from RNA polymerase III promoter (GO:0006385)2.43073712
103termination of RNA polymerase III transcription (GO:0006386)2.43073712
104protein-cofactor linkage (GO:0018065)2.42887377
105behavioral response to cocaine (GO:0048148)2.42448162
106mitochondrial transport (GO:0006839)2.41644455
107establishment of protein localization to mitochondrial membrane (GO:0090151)2.41480795
108positive regulation of potassium ion transmembrane transport (GO:1901381)2.41358940
109protein targeting to mitochondrion (GO:0006626)2.41104899
110cardiac conduction (GO:0061337)2.40334157
111purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.40192858
112purine nucleoside monophosphate biosynthetic process (GO:0009127)2.40192858
113removal of superoxide radicals (GO:0019430)2.39597942
114cellular response to superoxide (GO:0071451)2.39597942
115cellular response to oxygen radical (GO:0071450)2.39597942
116oxaloacetate metabolic process (GO:0006107)2.39322209
117response to nitrosative stress (GO:0051409)2.38888629
118negative regulation of heart rate (GO:0010459)2.38801832
119substantia nigra development (GO:0021762)2.38014343
120cellular protein complex disassembly (GO:0043624)2.37283475
121regulation of membrane repolarization (GO:0060306)2.37268298
122positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.36350626
123establishment of protein localization to mitochondrion (GO:0072655)2.35824492
124ubiquinone metabolic process (GO:0006743)2.35080968
125negative regulation of potassium ion transmembrane transport (GO:1901380)2.34990748
126* glutathione derivative biosynthetic process (GO:1901687)2.34201561
127* glutathione derivative metabolic process (GO:1901685)2.34201561
128long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.33618437
129regulation of voltage-gated calcium channel activity (GO:1901385)2.33010595
130regulation of skeletal muscle contraction (GO:0014819)2.32918880
131cullin deneddylation (GO:0010388)2.32793319
132positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.32599075
133negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.32544045
134negative regulation of calcium ion transmembrane transport (GO:1903170)2.32544045
135ubiquinone biosynthetic process (GO:0006744)2.32429134
136quinone biosynthetic process (GO:1901663)2.32429134
137xenobiotic catabolic process (GO:0042178)2.32330825
138viral life cycle (GO:0019058)2.30352208
139protein localization to mitochondrion (GO:0070585)2.30333169
140cellular response to zinc ion (GO:0071294)2.29223158
141short-term memory (GO:0007614)2.27051137
142ribosomal small subunit assembly (GO:0000028)2.27028154
143translation (GO:0006412)2.22103493
144phenol-containing compound catabolic process (GO:0019336)2.22028875
145vitamin biosynthetic process (GO:0009110)2.21433939
146lipid particle organization (GO:0034389)2.20964239
147regulation of sequestering of triglyceride (GO:0010889)2.18089425
148ribosomal small subunit biogenesis (GO:0042274)2.17064606
149negative regulation of cation channel activity (GO:2001258)2.15606253
150regulation of cellular respiration (GO:0043457)2.12699460
151cGMP-mediated signaling (GO:0019934)2.12527483

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.82583666
2* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.01443630
3GBX2_23144817_ChIP-Seq_PC3_Human3.01291204
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91206469
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.86323769
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73624249
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.63551115
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54245135
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50897627
10VDR_22108803_ChIP-Seq_LS180_Human2.50458213
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.32194418
12TAF15_26573619_Chip-Seq_HEK293_Human2.28914277
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24017552
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21748609
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15410799
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15024379
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11719571
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06722852
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03402327
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03301429
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02628868
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99526281
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99049086
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97952336
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97952336
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.96297389
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.96175924
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89775347
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.81509690
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.80661362
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80240105
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73557942
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72899270
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.67334723
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60626455
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.60410992
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60194840
38REST_21632747_ChIP-Seq_MESCs_Mouse1.56984258
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54577858
40ELK1_19687146_ChIP-ChIP_HELA_Human1.50467551
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47878393
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.45317438
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43181599
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.39717508
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36268253
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.34865238
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.31879497
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31096635
49* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30888737
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30694891
51P300_19829295_ChIP-Seq_ESCs_Human1.30296969
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28569181
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.28007469
54EWS_26573619_Chip-Seq_HEK293_Human1.27180197
55* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24508329
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23979135
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.23456848
58* ETS1_20019798_ChIP-Seq_JURKAT_Human1.22634827
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22468315
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21658021
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21199393
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.19417839
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18674321
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18645087
65* SMAD4_21799915_ChIP-Seq_A2780_Human1.16330339
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.15703393
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15494431
68AR_21572438_ChIP-Seq_LNCaP_Human1.15250288
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14976464
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14805224
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14466843
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14348535
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.13473923
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12870649
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12153988
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10976509
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10171667
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10106626
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09808239
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09715853
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09606602
82FUS_26573619_Chip-Seq_HEK293_Human1.09386852
83ER_23166858_ChIP-Seq_MCF-7_Human1.08194921
84BCAT_22108803_ChIP-Seq_LS180_Human1.07003431
85DROSHA_22980978_ChIP-Seq_HELA_Human1.05546569
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05421019
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05420513
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.05369251
89TP53_22573176_ChIP-Seq_HFKS_Human1.04872095
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03858951
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03748102
92TCF4_22108803_ChIP-Seq_LS180_Human1.03629326
93MYC_18940864_ChIP-ChIP_HL60_Human1.02252815
94* EZH2_27294783_Chip-Seq_NPCs_Mouse1.01405073
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00927598
96* RARB_27405468_Chip-Seq_BRAIN_Mouse1.00801633
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00091740
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.99715397
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99525037
100CBP_20019798_ChIP-Seq_JUKART_Human0.99525037
101EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98900577
102POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98822222
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97418440
104AR_25329375_ChIP-Seq_VCAP_Human0.95040617
105* NFE2_27457419_Chip-Seq_LIVER_Mouse0.94994597
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94923438
107* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94884084
108* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93953414
109HTT_18923047_ChIP-ChIP_STHdh_Human0.93891527
110FOXA1_25329375_ChIP-Seq_VCAP_Human0.93867709
111FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93867709
112ZNF274_21170338_ChIP-Seq_K562_Hela0.93866101
113KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93802334
114AR_20517297_ChIP-Seq_VCAP_Human0.92544387
115CTCF_27219007_Chip-Seq_Bcells_Human0.92402723
116ZNF263_19887448_ChIP-Seq_K562_Human0.92276454
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92069829
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91785669
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91294421
120JUN_21703547_ChIP-Seq_K562_Human0.89043855
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87764499
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87764499
123SOX2_21211035_ChIP-Seq_LN229_Gbm0.86575127
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84700752
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.79508828
126AHR_22903824_ChIP-Seq_MCF-7_Human0.79002548
127RNF2_27304074_Chip-Seq_NSC_Mouse0.78028851
128KDM2B_26808549_Chip-Seq_REH_Human0.77057101
129* NANOG_19829295_ChIP-Seq_ESCs_Human0.76365490
130* SOX2_19829295_ChIP-Seq_ESCs_Human0.76365490
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75986559
132RUNX2_22187159_ChIP-Seq_PCA_Human0.75780888
133SOX2_20726797_ChIP-Seq_SW620_Human0.75445575
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75432320
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75321212
136* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74765270
137MYC_19829295_ChIP-Seq_ESCs_Human0.73789276
138IGF1R_20145208_ChIP-Seq_DFB_Human0.73541666
139TP53_18474530_ChIP-ChIP_U2OS_Human0.73432898
140GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72333923
141CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.71393523
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.71150181
143EOMES_21245162_ChIP-Seq_HESCs_Human0.70767145
144THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.70538404
145* TAL1_26923725_Chip-Seq_HPCs_Mouse0.70451351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.06238001
2MP0003880_abnormal_central_pattern3.65173977
3MP0003646_muscle_fatigue3.27549668
4MP0000751_myopathy3.14306549
5MP0001529_abnormal_vocalization2.77976844
6MP0004215_abnormal_myocardial_fiber2.75841453
7MP0002822_catalepsy2.70331241
8MP0004147_increased_porphyrin_level2.69982252
9MP0003136_yellow_coat_color2.55293335
10MP0003011_delayed_dark_adaptation2.53892569
11MP0003186_abnormal_redox_activity2.41870611
12MP0000749_muscle_degeneration2.36966845
13MP0008004_abnormal_stomach_pH2.32643401
14MP0004270_analgesia2.29633636
15MP0002736_abnormal_nociception_after2.21926834
16MP0004036_abnormal_muscle_relaxation2.19743799
17MP0003656_abnormal_erythrocyte_physiolo2.18914559
18MP0001905_abnormal_dopamine_level2.15246111
19MP0006276_abnormal_autonomic_nervous2.13224770
20MP0004859_abnormal_synaptic_plasticity2.09160887
21MP0005670_abnormal_white_adipose2.05429760
22MP0001968_abnormal_touch/_nociception2.03669335
23MP0003635_abnormal_synaptic_transmissio2.03499466
24MP0002734_abnormal_mechanical_nocicepti1.99188780
25MP0006036_abnormal_mitochondrial_physio1.96561477
26MP0009745_abnormal_behavioral_response1.94488099
27MP0004084_abnormal_cardiac_muscle1.92933577
28MP0002272_abnormal_nervous_system1.91892014
29MP0004484_altered_response_of1.91257395
30MP0009046_muscle_twitch1.90010490
31MP0002064_seizures1.84623787
32MP0001440_abnormal_grooming_behavior1.83451528
33MP0002938_white_spotting1.77185243
34MP0001970_abnormal_pain_threshold1.69147048
35MP0002063_abnormal_learning/memory/cond1.66550002
36MP0002572_abnormal_emotion/affect_behav1.63485261
37MP0005085_abnormal_gallbladder_physiolo1.62994545
38MP0002972_abnormal_cardiac_muscle1.60791984
39MP0003137_abnormal_impulse_conducting1.59302269
40MP0002735_abnormal_chemical_nociception1.58651239
41MP0004019_abnormal_vitamin_homeostasis1.58277308
42MP0001501_abnormal_sleep_pattern1.55857826
43MP0005620_abnormal_muscle_contractility1.55441981
44MP0005330_cardiomyopathy1.53542066
45MP0002733_abnormal_thermal_nociception1.52269490
46MP0004924_abnormal_behavior1.51605681
47MP0005386_behavior/neurological_phenoty1.51605681
48MP0005551_abnormal_eye_electrophysiolog1.46700233
49MP0001664_abnormal_digestion1.46495112
50MP0005332_abnormal_amino_acid1.46218266
51MP0003195_calcinosis1.44769029
52MP0001984_abnormal_olfaction1.42726728
53MP0001486_abnormal_startle_reflex1.41949984
54MP0004043_abnormal_pH_regulation1.41241452
55MP0005365_abnormal_bile_salt1.40981598
56MP0002139_abnormal_hepatobiliary_system1.39208722
57MP0002067_abnormal_sensory_capabilities1.38439450
58MP0006035_abnormal_mitochondrial_morpho1.38087429
59MP0010386_abnormal_urinary_bladder1.34484482
60MP0006072_abnormal_retinal_apoptosis1.34125685
61MP0004145_abnormal_muscle_electrophysio1.32563895
62MP0004085_abnormal_heartbeat1.31600440
63MP0008775_abnormal_heart_ventricle1.30084686
64MP0004142_abnormal_muscle_tone1.27268360
65MP0005084_abnormal_gallbladder_morpholo1.25957288
66MP0010030_abnormal_orbit_morphology1.25643791
67MP0002332_abnormal_exercise_endurance1.24710906
68MP0005360_urolithiasis1.23233270
69MP0002106_abnormal_muscle_physiology1.20311186
70MP0002295_abnormal_pulmonary_circulatio1.18351630
71MP0002090_abnormal_vision1.18047964
72MP0003329_amyloid_beta_deposits1.16361980
73MP0004130_abnormal_muscle_cell1.15997142
74MP0005253_abnormal_eye_physiology1.14786947
75MP0005171_absent_coat_pigmentation1.11506010
76MP0008872_abnormal_physiological_respon1.11158082
77MP0004087_abnormal_muscle_fiber1.10752094
78MP0001764_abnormal_homeostasis1.05604232
79MP0001544_abnormal_cardiovascular_syste1.05127119
80MP0005385_cardiovascular_system_phenoty1.05127119
81MP0000538_abnormal_urinary_bladder1.04740963
82MP0001756_abnormal_urination1.02898728
83MP0002876_abnormal_thyroid_physiology1.02724775
84MP0005636_abnormal_mineral_homeostasis1.02638010
85MP0005535_abnormal_body_temperature1.01936735
86MP0000747_muscle_weakness1.01923271
87MP0008569_lethality_at_weaning1.01660888
88MP0009379_abnormal_foot_pigmentation1.01589201
89MP0006138_congestive_heart_failure1.01319434
90MP0000778_abnormal_nervous_system1.00599500
91MP0003879_abnormal_hair_cell1.00357413
92MP0002184_abnormal_innervation1.00016589
93MP0000013_abnormal_adipose_tissue1.00003271
94MP0005369_muscle_phenotype0.99337276
95MP0000759_abnormal_skeletal_muscle0.98105427
96MP0010329_abnormal_lipoprotein_level0.98059409
97MP0000343_altered_response_to0.96352635
98MP0005646_abnormal_pituitary_gland0.96098116
99MP0004858_abnormal_nervous_system0.95827089
100MP0002557_abnormal_social/conspecific_i0.95644787
101MP0002066_abnormal_motor_capabilities/c0.94278324
102MP0000750_abnormal_muscle_regeneration0.91729204
103MP0005408_hypopigmentation0.90587620
104MP0001765_abnormal_ion_homeostasis0.85008267
105MP0002229_neurodegeneration0.84758890
106MP0000026_abnormal_inner_ear0.83729352
107MP0005165_increased_susceptibility_to0.83705123
108MP0003806_abnormal_nucleotide_metabolis0.82824113
109MP0005423_abnormal_somatic_nervous0.82802455
110MP0002269_muscular_atrophy0.82591300
111MP0003950_abnormal_plasma_membrane0.82589007
112MP0000462_abnormal_digestive_system0.81996875
113MP0001485_abnormal_pinna_reflex0.81812354
114MP0005503_abnormal_tendon_morphology0.81560045
115MP0000230_abnormal_systemic_arterial0.81286791
116MP0002653_abnormal_ependyma_morphology0.80981475
117MP0002102_abnormal_ear_morphology0.80318682
118MP0005394_taste/olfaction_phenotype0.79243414
119MP0005499_abnormal_olfactory_system0.79243414
120MP0002909_abnormal_adrenal_gland0.78604996
121MP0004133_heterotaxia0.78067204
122MP0002882_abnormal_neuron_morphology0.77090110
123MP0003718_maternal_effect0.74937958
124MP0005595_abnormal_vascular_smooth0.74127508
125MP0008789_abnormal_olfactory_epithelium0.74021783
126MP0002971_abnormal_brown_adipose0.73521740
127MP0002638_abnormal_pupillary_reflex0.72637867
128MP0005451_abnormal_body_composition0.72255114
129MP0003633_abnormal_nervous_system0.71974135
130MP0000920_abnormal_myelination0.70301370
131MP0003631_nervous_system_phenotype0.70156706
132MP0008875_abnormal_xenobiotic_pharmacok0.69955309
133MP0005381_digestive/alimentary_phenotyp0.67357485
134MP0000372_irregular_coat_pigmentation0.67356620

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.51018242
2Abnormal mitochondria in muscle tissue (HP:0008316)6.05256850
3Acute encephalopathy (HP:0006846)5.58827419
4Progressive macrocephaly (HP:0004481)5.54476161
5Mitochondrial inheritance (HP:0001427)5.33794622
6Hepatocellular necrosis (HP:0001404)4.65119508
7Increased CSF lactate (HP:0002490)4.55448758
8Abnormality of glycolysis (HP:0004366)4.20323249
9Increased serum pyruvate (HP:0003542)4.20323249
10Hepatic necrosis (HP:0002605)4.14955593
11Sudden death (HP:0001699)3.96763998
12Cerebral edema (HP:0002181)3.93759463
13Pheochromocytoma (HP:0002666)3.63512148
14Focal motor seizures (HP:0011153)3.56186512
15Muscle hypertrophy of the lower extremities (HP:0008968)3.54277030
16Respiratory failure (HP:0002878)3.48933365
17Neuroendocrine neoplasm (HP:0100634)3.44981736
18Myokymia (HP:0002411)3.44547768
19Calf muscle hypertrophy (HP:0008981)3.44135218
203-Methylglutaconic aciduria (HP:0003535)3.41844755
21Increased hepatocellular lipid droplets (HP:0006565)3.32096424
22Lactic acidosis (HP:0003128)3.28159451
23Optic disc pallor (HP:0000543)3.28025740
24Lipid accumulation in hepatocytes (HP:0006561)3.21514294
25Leukodystrophy (HP:0002415)3.20061436
26Exercise intolerance (HP:0003546)3.18742921
27Palpitations (HP:0001962)3.13668015
28Increased intramyocellular lipid droplets (HP:0012240)3.04799671
29Syncope (HP:0001279)3.00517606
30Exercise-induced myalgia (HP:0003738)2.98743829
31Increased muscle lipid content (HP:0009058)2.94431337
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.85083896
33Renal Fanconi syndrome (HP:0001994)2.81659357
34Congenital, generalized hypertrichosis (HP:0004540)2.78115097
35Abnormal number of erythroid precursors (HP:0012131)2.73986587
36Myotonia (HP:0002486)2.72966437
37Ventricular tachycardia (HP:0004756)2.72342149
38Conjunctival hamartoma (HP:0100780)2.71137291
39Abnormality of cells of the erythroid lineage (HP:0012130)2.70092517
40Abnormality of the heme biosynthetic pathway (HP:0010472)2.69683909
41Right ventricular cardiomyopathy (HP:0011663)2.64811250
42Abnormal gallbladder physiology (HP:0012438)2.61111715
43Cholecystitis (HP:0001082)2.61111715
44X-linked dominant inheritance (HP:0001423)2.60522059
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59940461
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59940461
47Abnormality of the calf musculature (HP:0001430)2.59718692
48Increased serum lactate (HP:0002151)2.59446807
49Muscle fiber splitting (HP:0003555)2.59057459
50Macrocytic anemia (HP:0001972)2.52974492
51Atonic seizures (HP:0010819)2.52658858
52Ileus (HP:0002595)2.49702078
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.46672687
54Hyperphosphaturia (HP:0003109)2.45142992
55Polyphagia (HP:0002591)2.44469302
56True hermaphroditism (HP:0010459)2.41061297
57Generalized aminoaciduria (HP:0002909)2.40671493
58Cholelithiasis (HP:0001081)2.38596167
59Molar tooth sign on MRI (HP:0002419)2.36022754
60Abnormality of midbrain morphology (HP:0002418)2.36022754
61Exercise-induced muscle cramps (HP:0003710)2.35792421
62Methylmalonic aciduria (HP:0012120)2.31872730
63Atrial fibrillation (HP:0005110)2.26446676
64Abnormal gallbladder morphology (HP:0012437)2.25722491
65Medial flaring of the eyebrow (HP:0010747)2.24843495
66Nausea (HP:0002018)2.24381954
67Pancreatic fibrosis (HP:0100732)2.23076725
68Prolonged QT interval (HP:0001657)2.21254096
69Myoglobinuria (HP:0002913)2.18837852
70Hyporeflexia of lower limbs (HP:0002600)2.17943833
71Primary atrial arrhythmia (HP:0001692)2.17461970
72Methylmalonic acidemia (HP:0002912)2.17270161
73Muscle stiffness (HP:0003552)2.16700989
74Lethargy (HP:0001254)2.15396836
75Abnormality of the vocal cords (HP:0008777)2.14379090
76Hypothermia (HP:0002045)2.13848558
77Ventricular fibrillation (HP:0001663)2.13387574
78CNS demyelination (HP:0007305)2.13012208
79Supraventricular tachycardia (HP:0004755)2.12033915
80Lipoatrophy (HP:0100578)2.11639665
81Focal seizures (HP:0007359)2.11347794
82Dicarboxylic aciduria (HP:0003215)2.10388247
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10388247
84Termporal pattern (HP:0011008)2.09752747
85Insidious onset (HP:0003587)2.09752747
86Cerebral hemorrhage (HP:0001342)2.09734130
87Pancreatic cysts (HP:0001737)2.08536407
88Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.07045526
89Degeneration of the lateral corticospinal tracts (HP:0002314)2.07045526
90Parakeratosis (HP:0001036)2.05460279
91Epileptic encephalopathy (HP:0200134)2.05273109
92Supraventricular arrhythmia (HP:0005115)2.04855681
93Nemaline bodies (HP:0003798)2.01302134
94Muscle fiber inclusion bodies (HP:0100299)2.01257448
95Renal tubular dysfunction (HP:0000124)2.00729548
96Emotional lability (HP:0000712)1.99337922
97Confusion (HP:0001289)1.98938678
98Oligomenorrhea (HP:0000876)1.97641961
99Gait imbalance (HP:0002141)1.97537840
100Limb dystonia (HP:0002451)1.95711251
101Respiratory difficulties (HP:0002880)1.95465156
102Anxiety (HP:0000739)1.95433695
103Nephronophthisis (HP:0000090)1.94894498
104Vomiting (HP:0002013)1.94327890
105Abnormality of renal resorption (HP:0011038)1.93708160
106Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.93325830
107Absence seizures (HP:0002121)1.92767703
108EMG: myopathic abnormalities (HP:0003458)1.92561434
109Hyperventilation (HP:0002883)1.90942084
110Abnormality of serum amino acid levels (HP:0003112)1.89383547
111Hyperglycinemia (HP:0002154)1.88475092
112Abnormality of vitamin B metabolism (HP:0004340)1.86283677
113Hypoglycemic coma (HP:0001325)1.85650845
114Generalized tonic-clonic seizures (HP:0002069)1.85371759
115Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85136321
116Fragile nails (HP:0001808)1.84233788
117Febrile seizures (HP:0002373)1.84190877
118Diaphragmatic weakness (HP:0009113)1.83283028
119Abnormal urine phosphate concentration (HP:0012599)1.82928013
120Ketoacidosis (HP:0001993)1.82149770
121Visual hallucinations (HP:0002367)1.81757905
122Abnormality of glutamine family amino acid metabolism (HP:0010902)1.81412024
123Congenital primary aphakia (HP:0007707)1.81407971
124Abnormality of the vitamin B12 metabolism (HP:0004341)1.81191231
125Glycosuria (HP:0003076)1.81028564
126Abnormality of urine glucose concentration (HP:0011016)1.81028564
127Exertional dyspnea (HP:0002875)1.79799339
128Nephrogenic diabetes insipidus (HP:0009806)1.75881102
129Abnormality of alanine metabolism (HP:0010916)1.75421494
130Hyperalaninemia (HP:0003348)1.75421494
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75421494
132Left ventricular hypertrophy (HP:0001712)1.74901971
133Rhabdomyolysis (HP:0003201)1.74387480
134Metabolic acidosis (HP:0001942)1.74324853
135Ventricular arrhythmia (HP:0004308)1.73693265
136Dialeptic seizures (HP:0011146)1.73533515
137Hyperglycinuria (HP:0003108)1.73515303
138Neoplasm of the peripheral nervous system (HP:0100007)1.72462574
139Male pseudohermaphroditism (HP:0000037)1.66848997
140Genital tract atresia (HP:0001827)1.64828189
141Blindness (HP:0000618)1.64146995
142Type I transferrin isoform profile (HP:0003642)1.62764802
143Vaginal atresia (HP:0000148)1.61897938
144Abnormal eating behavior (HP:0100738)1.61778776
145Reticulocytopenia (HP:0001896)1.61215647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.39490511
2MAP3K123.32333442
3NME13.04584908
4MYLK2.95621216
5STK162.46147494
6LMTK22.42484588
7ARAF2.39680358
8MAP3K42.31314191
9MAPKAPK52.26787595
10GRK72.22949521
11VRK22.19493009
12GRK52.15951104
13PHKG12.11147249
14PHKG22.11147249
15STK392.10642637
16MAP2K72.07128941
17OXSR12.06808179
18WNK42.03300722
19PDK41.93003290
20PDK31.93003290
21TNIK1.83859394
22FRK1.82939828
23ACVR1B1.79801388
24OBSCN1.76533618
25CDK191.69304867
26PIK3CA1.68264863
27MARK11.58252524
28EPHA41.57148482
29MAP2K41.57021070
30PLK21.56522220
31MUSK1.51459295
32MST41.48949930
33MAPK131.44985426
34ZAK1.41553479
35MAP4K21.40965411
36GRK11.38674781
37VRK11.37806718
38TTN1.36442606
39TIE11.33218556
40MINK11.32512932
41NTRK31.26993666
42CAMK2D1.26159708
43MST1R1.24336138
44TESK11.23872413
45DAPK21.23458142
46CAMK2A1.22832326
47MAP3K91.19283825
48LIMK11.18308367
49PDK21.16608570
50TLK11.15671642
51INSRR1.14231333
52CAMK2B1.13405959
53KSR21.13132572
54BRAF1.11846796
55BMPR21.06729873
56STK240.99316684
57PBK0.98826945
58MAP2K10.98065901
59SGK2230.97694260
60SGK4940.97694260
61DAPK30.96580561
62CSNK1G20.95705071
63PTK2B0.93826036
64ERBB40.92128982
65DYRK20.92048097
66PRKCE0.89355593
67CAMK2G0.89319087
68MAPKAPK30.88372956
69MAPK120.88028057
70CSNK1G10.87683734
71EPHB20.86393295
72NEK10.84974929
73BCKDK0.82696566
74CSNK1G30.81558617
75MAP3K60.80613607
76ADRBK10.77583851
77PAK30.77276769
78DAPK10.76983263
79FGR0.74707881
80NUAK10.74076053
81WNK30.73842410
82CAMK10.72983492
83CDK50.72684884
84ROCK20.71743969
85ILK0.71541653
86RIPK40.71331566
87UHMK10.68868667
88PINK10.68493637
89PRKG10.66309246
90MAP3K20.65565896
91ABL20.65424111
92MAPK150.64553043
93PNCK0.62772871
94PKN10.61817223
95DDR20.61510852
96PRKACA0.60540862
97GRK60.60311631
98NME20.60283934
99PRKG20.59428083
100PIM20.59128268
101DYRK30.58382568
102NTRK10.58221526
103FER0.56438404
104NTRK20.55923482
105CDK180.54618452
106CSNK1A1L0.54374671
107CDK140.53782344
108CDK150.53037293
109BRSK20.50715830
110BCR0.50625114
111MAP2K20.49441202
112ERBB30.49171987
113PRKCG0.49144109
114DMPK0.47980481
115STK38L0.47250306
116PLK30.46273128
117CAMKK20.45539491
118RPS6KA50.45417341
119CDK11A0.45058469
120CSNK1A10.44761278
121PRKACG0.44218466
122MAP3K110.43293274
123WNK10.42901618
124BMPR1B0.41183754
125PDPK10.40946674
126AKT30.40492929
127ROCK10.40198191
128EIF2AK10.39611955
129PAK60.38792862
130NLK0.36981048
131PRKD10.35362040
132PRKACB0.33387578
133ADRBK20.32557067
134MAPK40.31729493
135PRKCA0.31289386

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.50874352
2Parkinsons disease_Homo sapiens_hsa050124.64554207
3Alzheimers disease_Homo sapiens_hsa050103.66340927
4Huntingtons disease_Homo sapiens_hsa050163.12051502
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.10763762
6Cardiac muscle contraction_Homo sapiens_hsa042602.97031914
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.88130506
8Collecting duct acid secretion_Homo sapiens_hsa049662.81632984
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.59227211
10Protein export_Homo sapiens_hsa030602.36283954
11Pyruvate metabolism_Homo sapiens_hsa006202.05504939
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.95636734
13Sulfur metabolism_Homo sapiens_hsa009201.95323160
14Synaptic vesicle cycle_Homo sapiens_hsa047211.94977389
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91539936
16Fatty acid elongation_Homo sapiens_hsa000621.89631193
17Propanoate metabolism_Homo sapiens_hsa006401.78734595
18Folate biosynthesis_Homo sapiens_hsa007901.52070127
19Butanoate metabolism_Homo sapiens_hsa006501.46614751
20Tryptophan metabolism_Homo sapiens_hsa003801.44879378
21Vibrio cholerae infection_Homo sapiens_hsa051101.38722550
22Nicotine addiction_Homo sapiens_hsa050331.38060690
23Nitrogen metabolism_Homo sapiens_hsa009101.33778527
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.32506985
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32356394
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26006048
27RNA polymerase_Homo sapiens_hsa030201.23778952
28* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21259653
29* Chemical carcinogenesis_Homo sapiens_hsa052041.18718354
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16492007
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13043661
32Sulfur relay system_Homo sapiens_hsa041221.12933615
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11857581
34Olfactory transduction_Homo sapiens_hsa047401.10066298
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09004782
36Carbon metabolism_Homo sapiens_hsa012001.08185952
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07094192
38Serotonergic synapse_Homo sapiens_hsa047261.06878337
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06376405
40Gastric acid secretion_Homo sapiens_hsa049711.03392628
41Phenylalanine metabolism_Homo sapiens_hsa003601.01944767
42Retinol metabolism_Homo sapiens_hsa008301.01212515
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99339740
44GABAergic synapse_Homo sapiens_hsa047270.98921368
45Taste transduction_Homo sapiens_hsa047420.98126059
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97612341
47Circadian entrainment_Homo sapiens_hsa047130.97449134
48Fatty acid metabolism_Homo sapiens_hsa012120.94741545
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93945444
50Dopaminergic synapse_Homo sapiens_hsa047280.91554592
51Ether lipid metabolism_Homo sapiens_hsa005650.89838897
52Dilated cardiomyopathy_Homo sapiens_hsa054140.89777849
53Proteasome_Homo sapiens_hsa030500.88602112
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.88083311
55Salivary secretion_Homo sapiens_hsa049700.87339459
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87139226
57Renin secretion_Homo sapiens_hsa049240.86393346
58Fatty acid degradation_Homo sapiens_hsa000710.85203129
59Steroid biosynthesis_Homo sapiens_hsa001000.84698045
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83387122
61Morphine addiction_Homo sapiens_hsa050320.82767409
62Glutamatergic synapse_Homo sapiens_hsa047240.81947165
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81334155
64Amphetamine addiction_Homo sapiens_hsa050310.80793310
65Vitamin digestion and absorption_Homo sapiens_hsa049770.80790743
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80137910
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78507254
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78460601
69Tyrosine metabolism_Homo sapiens_hsa003500.78002885
70Histidine metabolism_Homo sapiens_hsa003400.77958771
71Caffeine metabolism_Homo sapiens_hsa002320.77499373
72Linoleic acid metabolism_Homo sapiens_hsa005910.75225517
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74929244
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72621319
75Cholinergic synapse_Homo sapiens_hsa047250.72567468
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71455595
77Long-term potentiation_Homo sapiens_hsa047200.71370435
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70118981
79Insulin secretion_Homo sapiens_hsa049110.69593093
80Calcium signaling pathway_Homo sapiens_hsa040200.67627182
81Mineral absorption_Homo sapiens_hsa049780.67622644
82Arginine biosynthesis_Homo sapiens_hsa002200.66730567
83Fat digestion and absorption_Homo sapiens_hsa049750.66656050
84Metabolic pathways_Homo sapiens_hsa011000.64793466
85Starch and sucrose metabolism_Homo sapiens_hsa005000.62836261
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.61851974
87Long-term depression_Homo sapiens_hsa047300.57408212
88beta-Alanine metabolism_Homo sapiens_hsa004100.54550784
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54238281
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53938380
91Gap junction_Homo sapiens_hsa045400.53424642
92Purine metabolism_Homo sapiens_hsa002300.52361270
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.52007716
94Rheumatoid arthritis_Homo sapiens_hsa053230.51188063
95Oxytocin signaling pathway_Homo sapiens_hsa049210.51130673
96Renin-angiotensin system_Homo sapiens_hsa046140.50108271
97Cocaine addiction_Homo sapiens_hsa050300.50048849
98GnRH signaling pathway_Homo sapiens_hsa049120.50037651
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.49101108
100Regulation of autophagy_Homo sapiens_hsa041400.48791195
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45913668
102Phototransduction_Homo sapiens_hsa047440.44892067
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43746544
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43111501
105Pancreatic secretion_Homo sapiens_hsa049720.42904120
106Arginine and proline metabolism_Homo sapiens_hsa003300.42555195
107PPAR signaling pathway_Homo sapiens_hsa033200.42310312
108Peroxisome_Homo sapiens_hsa041460.42267780
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41380800
110Homologous recombination_Homo sapiens_hsa034400.40803516
111Circadian rhythm_Homo sapiens_hsa047100.40764931
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.40755789
113* Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40751030
114Basal transcription factors_Homo sapiens_hsa030220.40004640
115Fructose and mannose metabolism_Homo sapiens_hsa000510.39333470
116Arachidonic acid metabolism_Homo sapiens_hsa005900.39267363
117Vitamin B6 metabolism_Homo sapiens_hsa007500.38876923
118Phagosome_Homo sapiens_hsa041450.38469670
119Protein digestion and absorption_Homo sapiens_hsa049740.37803984
120Ribosome_Homo sapiens_hsa030100.37476832
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35732756
122Nucleotide excision repair_Homo sapiens_hsa034200.34354263
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34205966
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31918095
125Galactose metabolism_Homo sapiens_hsa000520.30974436
126Tight junction_Homo sapiens_hsa045300.30694713
127* Glutathione metabolism_Homo sapiens_hsa004800.29869470
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29416588
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.28070440
130Bile secretion_Homo sapiens_hsa049760.27815572
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27076494
132Glycerolipid metabolism_Homo sapiens_hsa005610.26975698
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26373774

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