MIA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.28659503
2L-phenylalanine catabolic process (GO:0006559)7.28659503
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.94395311
4L-phenylalanine metabolic process (GO:0006558)6.94395311
5aromatic amino acid family catabolic process (GO:0009074)6.56139323
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.20714464
7indole-containing compound catabolic process (GO:0042436)5.91458234
8indolalkylamine catabolic process (GO:0046218)5.91458234
9tryptophan catabolic process (GO:0006569)5.91458234
10kynurenine metabolic process (GO:0070189)5.77875504
11bile acid biosynthetic process (GO:0006699)5.77076115
12water-soluble vitamin biosynthetic process (GO:0042364)5.74671884
13tryptophan metabolic process (GO:0006568)5.59656255
14urea metabolic process (GO:0019627)5.57284738
15urea cycle (GO:0000050)5.57284738
16glyoxylate metabolic process (GO:0046487)5.56517179
17alpha-linolenic acid metabolic process (GO:0036109)5.54985817
18cysteine metabolic process (GO:0006534)5.43110288
19high-density lipoprotein particle remodeling (GO:0034375)5.32331031
20negative regulation of fibrinolysis (GO:0051918)5.21372526
21sulfur amino acid catabolic process (GO:0000098)5.19385516
22complement activation, alternative pathway (GO:0006957)5.15543214
23nitrogen cycle metabolic process (GO:0071941)5.11826733
24regulation of protein activation cascade (GO:2000257)5.11177545
25protein carboxylation (GO:0018214)5.07724551
26peptidyl-glutamic acid carboxylation (GO:0017187)5.07724551
27regulation of fibrinolysis (GO:0051917)5.02254406
28bile acid metabolic process (GO:0008206)5.02128861
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.97094451
30homocysteine metabolic process (GO:0050667)4.95621364
31serine family amino acid catabolic process (GO:0009071)4.92732731
32epithelial cell fate commitment (GO:0072148)4.80612789
33regulation of triglyceride catabolic process (GO:0010896)4.80188898
34regulation of complement activation (GO:0030449)4.78860568
35regulation of cholesterol esterification (GO:0010872)4.77188887
36aromatic amino acid family metabolic process (GO:0009072)4.77172583
37reverse cholesterol transport (GO:0043691)4.76289011
38lysine catabolic process (GO:0006554)4.73299146
39lysine metabolic process (GO:0006553)4.73299146
40plasma lipoprotein particle remodeling (GO:0034369)4.63112091
41protein-lipid complex remodeling (GO:0034368)4.63112091
42macromolecular complex remodeling (GO:0034367)4.63112091
43amino-acid betaine metabolic process (GO:0006577)4.59439402
44phospholipid efflux (GO:0033700)4.56300389
45bile acid and bile salt transport (GO:0015721)4.55492278
46tyrosine metabolic process (GO:0006570)4.55327100
47negative regulation of sterol transport (GO:0032372)4.49514226
48negative regulation of cholesterol transport (GO:0032375)4.49514226
49alpha-amino acid catabolic process (GO:1901606)4.48966208
50dopamine transport (GO:0015872)4.37081024
51* triglyceride homeostasis (GO:0070328)4.30494225
52* acylglycerol homeostasis (GO:0055090)4.30494225
53cellular ketone body metabolic process (GO:0046950)4.30222924
54drug catabolic process (GO:0042737)4.29443929
55cellular glucuronidation (GO:0052695)4.29076631
56cholesterol efflux (GO:0033344)4.26542042
57indolalkylamine metabolic process (GO:0006586)4.23324829
58intestinal cholesterol absorption (GO:0030299)4.22761826
59glycine metabolic process (GO:0006544)4.20992870
60plasma lipoprotein particle clearance (GO:0034381)4.20442323
61coenzyme catabolic process (GO:0009109)4.19630080
62glutamate metabolic process (GO:0006536)4.16672411
63cellular amino acid catabolic process (GO:0009063)4.16555793
64regulation of bile acid biosynthetic process (GO:0070857)4.12448173
65serine family amino acid metabolic process (GO:0009069)4.11682482
66plasma lipoprotein particle assembly (GO:0034377)4.09308159
67cellular biogenic amine catabolic process (GO:0042402)4.06106510
68amine catabolic process (GO:0009310)4.06106510
69cellular modified amino acid catabolic process (GO:0042219)4.04852898
70imidazole-containing compound metabolic process (GO:0052803)4.02713097
71astrocyte differentiation (GO:0048708)4.01717013
72benzene-containing compound metabolic process (GO:0042537)3.99596363
73ethanol oxidation (GO:0006069)3.98029931
74serine family amino acid biosynthetic process (GO:0009070)3.91017338
75dicarboxylic acid biosynthetic process (GO:0043650)3.87771215
76regulation of cholesterol homeostasis (GO:2000188)3.87691377
77positive regulation of lipoprotein lipase activity (GO:0051006)3.85276815
78positive regulation of triglyceride lipase activity (GO:0061365)3.85276815
79very-low-density lipoprotein particle assembly (GO:0034379)3.84222098
80phospholipid homeostasis (GO:0055091)3.83814201
81low-density lipoprotein particle remodeling (GO:0034374)3.83643710
82glucuronate metabolic process (GO:0019585)3.82017720
83uronic acid metabolic process (GO:0006063)3.82017720
84arginine metabolic process (GO:0006525)3.79720176
85* cholesterol homeostasis (GO:0042632)3.76571705
86endocrine pancreas development (GO:0031018)3.76348982
87drug transmembrane transport (GO:0006855)3.75616619
88fibrinolysis (GO:0042730)3.74918980
89insulin secretion (GO:0030073)3.73587110
90regulation of cytokine production involved in inflammatory response (GO:1900015)3.73021946
91positive regulation of lipid catabolic process (GO:0050996)3.72896230
92ketone body metabolic process (GO:1902224)3.71696848
93* sterol homeostasis (GO:0055092)3.71306544
94aldehyde catabolic process (GO:0046185)3.71254618
95protein-lipid complex assembly (GO:0065005)3.69770901
96short-chain fatty acid metabolic process (GO:0046459)3.68691898
97organic acid catabolic process (GO:0016054)3.67982638
98carboxylic acid catabolic process (GO:0046395)3.67982638
99flavonoid metabolic process (GO:0009812)3.67259376
100lipoprotein metabolic process (GO:0042157)3.65519735
101acetyl-CoA metabolic process (GO:0006084)3.62710070
102plasma lipoprotein particle organization (GO:0071827)3.57428185
103complement activation, classical pathway (GO:0006958)3.56258490
104urate metabolic process (GO:0046415)3.55649578
105lactate metabolic process (GO:0006089)3.55205507
106cofactor catabolic process (GO:0051187)3.55202262
107complement activation (GO:0006956)3.52834260
108blood coagulation, intrinsic pathway (GO:0007597)3.52829638
109regulation of glucokinase activity (GO:0033131)3.50087565
110regulation of hexokinase activity (GO:1903299)3.50087565
111alanine transport (GO:0032328)3.49172013
112regulation of type B pancreatic cell apoptotic process (GO:2000674)3.48883025
113glycerophospholipid catabolic process (GO:0046475)3.47408893
114inositol phosphate catabolic process (GO:0071545)3.46805671
115ubiquinone metabolic process (GO:0006743)3.40088744
116negative regulation of cytosolic calcium ion concentration (GO:0051481)3.36866161
117early endosome to late endosome transport (GO:0045022)3.36840440
118catecholamine transport (GO:0051937)3.34874056
119auditory receptor cell differentiation (GO:0042491)3.34209245
120regulation of acrosome reaction (GO:0060046)3.32860888
121L-ascorbic acid metabolic process (GO:0019852)3.29602326
122peptide hormone processing (GO:0016486)3.26426728
123detection of light stimulus involved in visual perception (GO:0050908)3.25953172
124detection of light stimulus involved in sensory perception (GO:0050962)3.25953172
125fucose catabolic process (GO:0019317)3.25682147
126L-fucose metabolic process (GO:0042354)3.25682147
127L-fucose catabolic process (GO:0042355)3.25682147
128proline transport (GO:0015824)3.23156491
129positive regulation of insulin secretion (GO:0032024)3.20329420
130inositol phosphate dephosphorylation (GO:0046855)3.17341167
131phosphorylated carbohydrate dephosphorylation (GO:0046838)3.17341167
132estrogen biosynthetic process (GO:0006703)3.12667908
133protein-chromophore linkage (GO:0018298)3.11103102
134kidney morphogenesis (GO:0060993)3.11095925
135positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.08842309
136signal peptide processing (GO:0006465)3.08505647
137toxin metabolic process (GO:0009404)3.08255806
138respiratory chain complex IV assembly (GO:0008535)3.07498523
139establishment of protein localization to Golgi (GO:0072600)3.06061584
140phenylpropanoid metabolic process (GO:0009698)3.04814009
141ubiquinone biosynthetic process (GO:0006744)3.04077302
142alkaloid metabolic process (GO:0009820)2.96692558
143protein targeting to Golgi (GO:0000042)2.93212433
144serotonin metabolic process (GO:0042428)2.89921101
145polyol catabolic process (GO:0046174)2.88744528
146vitamin biosynthetic process (GO:0009110)2.88373917
147positive regulation of peptide hormone secretion (GO:0090277)2.88124118
148primary amino compound metabolic process (GO:1901160)2.85396621
149cytochrome complex assembly (GO:0017004)2.80144529
150quinone biosynthetic process (GO:1901663)2.78696874
151xenobiotic catabolic process (GO:0042178)2.77344709
152axoneme assembly (GO:0035082)2.76478974
153glandular epithelial cell differentiation (GO:0002067)2.75965838
154positive regulation of peptide secretion (GO:0002793)2.74406774
155retrograde transport, vesicle recycling within Golgi (GO:0000301)2.71957695
156protein localization to Golgi apparatus (GO:0034067)2.70089024
157regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.67761414
158nitric oxide mediated signal transduction (GO:0007263)2.67616273
159organic cation transport (GO:0015695)2.67573993
160negative regulation of execution phase of apoptosis (GO:1900118)2.66212092
161nephron tubule morphogenesis (GO:0072078)2.66147662
162nephron epithelium morphogenesis (GO:0072088)2.66147662
163positive regulation of meiosis (GO:0045836)2.65817275
164regulation of glucocorticoid secretion (GO:2000849)2.64694104
165response to corticosterone (GO:0051412)2.64338731
166behavioral response to nicotine (GO:0035095)2.63753247
167calcium ion import (GO:0070509)2.63720929
168dopamine biosynthetic process (GO:0042416)2.62829209
169positive regulation of gluconeogenesis (GO:0045722)2.60490608
170positive regulation of glycolytic process (GO:0045821)2.59519047
171dorsal/ventral axis specification (GO:0009950)2.57784969
172intra-Golgi vesicle-mediated transport (GO:0006891)2.57056365
173macroautophagy (GO:0016236)2.53333915
174nodal signaling pathway (GO:0038092)2.51078047
175phospholipid catabolic process (GO:0009395)2.49488744
176protein complex biogenesis (GO:0070271)2.48401372
177estrogen metabolic process (GO:0008210)2.48090991
178positive regulation of meiotic cell cycle (GO:0051446)2.47624329
179regulation of neurotransmitter uptake (GO:0051580)2.46579434
180exogenous drug catabolic process (GO:0042738)2.46200947
181detection of calcium ion (GO:0005513)2.42270440
182indole-containing compound metabolic process (GO:0042430)2.41022332
183peptide hormone secretion (GO:0030072)2.38785442

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.20057271
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.06262492
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.76759079
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.45463997
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.11521209
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.83747746
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.51139182
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.07123912
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.80001058
10GBX2_23144817_ChIP-Seq_PC3_Human2.67869528
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.57691672
12ZNF274_21170338_ChIP-Seq_K562_Hela2.37940479
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.32054622
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26221775
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20745070
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.16761371
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04982554
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5069663
19IGF1R_20145208_ChIP-Seq_DFB_Human1.98592568
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91274886
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90124483
22VDR_22108803_ChIP-Seq_LS180_Human1.88649879
23FUS_26573619_Chip-Seq_HEK293_Human1.88415857
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83581200
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.81525873
26GATA1_22025678_ChIP-Seq_K562_Human1.76516953
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74406069
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.74160288
29P300_19829295_ChIP-Seq_ESCs_Human1.74140641
30CLOCK_20551151_ChIP-Seq_293T_Human1.68707048
31ER_23166858_ChIP-Seq_MCF-7_Human1.66284792
32SMAD4_21799915_ChIP-Seq_A2780_Human1.66251283
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62021481
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60759248
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.56199762
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51866628
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51684705
38* HNF4A_19822575_ChIP-Seq_HepG2_Human1.50772455
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.49013769
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.48669854
41HTT_18923047_ChIP-ChIP_STHdh_Human1.47032174
42STAT3_23295773_ChIP-Seq_U87_Human1.46274664
43AR_25329375_ChIP-Seq_VCAP_Human1.44344350
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43456452
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43434559
46SOX2_19829295_ChIP-Seq_ESCs_Human1.38477489
47NANOG_19829295_ChIP-Seq_ESCs_Human1.38477489
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36016442
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35767862
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35265396
51* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34726676
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.34635709
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33773164
54TCF4_23295773_ChIP-Seq_U87_Human1.33366733
55SOX2_18555785_Chip-Seq_ESCs_Mouse1.33308403
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33266779
57* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32337833
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.31637028
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31637028
60CBP_20019798_ChIP-Seq_JUKART_Human1.31097579
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31097579
62TP53_22573176_ChIP-Seq_HFKS_Human1.30245267
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.30205945
64P53_22387025_ChIP-Seq_ESCs_Mouse1.29955014
65EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.28779693
66STAT3_18555785_Chip-Seq_ESCs_Mouse1.27910468
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.27392080
68TCF4_22108803_ChIP-Seq_LS180_Human1.26743939
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26401144
70EWS_26573619_Chip-Seq_HEK293_Human1.26345557
71NMYC_18555785_Chip-Seq_ESCs_Mouse1.25181429
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.25070168
73P300_18555785_Chip-Seq_ESCs_Mouse1.21091811
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.19895371
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19158607
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18186930
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16984240
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16659386
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15944943
80* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15045849
81RUNX2_22187159_ChIP-Seq_PCA_Human1.14086705
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.13844459
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12584950
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12482245
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11988555
86REST_21632747_ChIP-Seq_MESCs_Mouse1.11579396
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.11486331
88CTCF_18555785_Chip-Seq_ESCs_Mouse1.11275612
89* GATA4_25053715_ChIP-Seq_YYC3_Human1.11198178
90RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11093989
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.10879068
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09574239
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.08897104
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.08339019
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07833388
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07627319
97PHF8_20622853_ChIP-Seq_HELA_Human1.07604120
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07071082
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07004915
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.05220361
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04592567
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04483238
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02202598
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02049636
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01966744
106IRF1_19129219_ChIP-ChIP_H3396_Human1.01843261
107NCOR_22424771_ChIP-Seq_293T_Human1.01652459
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01558285
109ZFX_18555785_Chip-Seq_ESCs_Mouse0.99608513
110NFYB_21822215_ChIP-Seq_K562_Human0.99539328
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97356655
112CDX2_20551321_ChIP-Seq_CACO-2_Human0.91696004
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89049906
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87194220
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86312693
116IRF8_22096565_ChIP-ChIP_GC-B_Human0.86225564
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85841795
118ESR2_21235772_ChIP-Seq_MCF-7_Human0.85638535
119RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82987600
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82092780
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81633588
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77842225
123KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76129458
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76039142
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74357100
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73850399
127RARA_24833708_ChIP-Seq_LIVER_Mouse0.73588274
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72322363
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71969187
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71071992
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71071992
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70849659
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70676985
134ESR1_21235772_ChIP-Seq_MCF-7_Human0.70380907
135ZNF263_19887448_ChIP-Seq_K562_Human0.70363181
136GATA6_25053715_ChIP-Seq_YYC3_Human0.70254743
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69265157
138FOXA1_25552417_ChIP-Seq_VCAP_Human0.66328429
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.65914048
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.62129370
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61772622
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.60674915
143RARB_24833708_ChIP-Seq_LIVER_Mouse0.59348405
144BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59269603
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58693416
146SOX2_20726797_ChIP-Seq_SW620_Human0.58672170
147EGR1_19032775_ChIP-ChIP_M12_Human0.57856988
148CEBPB_22108803_ChIP-Seq_LS180_Human0.56943204
149PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.56856963
150RAD21_21589869_ChIP-Seq_MESCs_Mouse0.55959051
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.54517751
152STAT1_17558387_ChIP-Seq_HELA_Human0.54232518
153AR_20517297_ChIP-Seq_VCAP_Human0.54086959
154NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.53265285
155MYC_19915707_ChIP-ChIP_AK7_Human0.52567443
156GATA2_19941826_ChIP-Seq_K562_Human0.51453705
157CBP_21632823_ChIP-Seq_H3396_Human0.51369898
158ESET_19884257_ChIP-Seq_ESCs_Mouse0.51356680
159FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.50252044
160GATA1_19941826_ChIP-Seq_K562_Human0.49877428
161LXR_22292898_ChIP-Seq_THP-1_Human0.49481255
162PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.48813877
163ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.48417917
164STAT3_1855785_ChIP-Seq_MESCs_Mouse0.47537327
165CDX2_22108803_ChIP-Seq_LS180_Human0.46715085
166PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46329558
167CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.45437913
168GATA3_24758297_ChIP-Seq_MCF-7_Human0.45163080
169P53_21459846_ChIP-Seq_SAOS-2_Human0.44022804
170BCAT_22108803_ChIP-Seq_LS180_Human0.43130550
171EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.41805246
172PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41771612
173GATA1_19941827_ChIP-Seq_MEL_Mouse0.40659677
174ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.40422608
175ERG_20517297_ChIP-Seq_VCAP_Human0.39723886
176TAF15_26573619_Chip-Seq_HEK293_Human0.39001442
177SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.38658349
178ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.38482360
179* TAF2_19829295_ChIP-Seq_ESCs_Human0.37432377
180PIAS1_25552417_ChIP-Seq_VCAP_Human0.37366286
181AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.37255574
182GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.35814004
183SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.35774073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.15169185
2MP0005360_urolithiasis7.81134637
3MP0005085_abnormal_gallbladder_physiolo6.38512932
4MP0005365_abnormal_bile_salt6.10249011
5MP0008875_abnormal_xenobiotic_pharmacok5.03680691
6MP0003252_abnormal_bile_duct4.12400561
7MP0003806_abnormal_nucleotide_metabolis3.98432953
8MP0002638_abnormal_pupillary_reflex3.65757118
9MP0005379_endocrine/exocrine_gland_phen3.56453929
10MP0010329_abnormal_lipoprotein_level3.50506530
11MP0002909_abnormal_adrenal_gland3.50159608
12MP0009840_abnormal_foam_cell3.21495742
13MP0001666_abnormal_nutrient_absorption3.08430068
14MP0005083_abnormal_biliary_tract2.99320720
15MP0002163_abnormal_gland_morphology2.85460794
16MP0003195_calcinosis2.78441438
17MP0005332_abnormal_amino_acid2.76898071
18MP0009780_abnormal_chondrocyte_physiolo2.76527729
19MP0009046_muscle_twitch2.62319417
20MP0005645_abnormal_hypothalamus_physiol2.58690691
21MP0003787_abnormal_imprinting2.35546404
22MP0002693_abnormal_pancreas_physiology2.35416100
23MP0004019_abnormal_vitamin_homeostasis2.32279802
24MP0002138_abnormal_hepatobiliary_system2.12856267
25MP0000609_abnormal_liver_physiology2.11687412
26MP0003191_abnormal_cellular_cholesterol2.08633064
27MP0002118_abnormal_lipid_homeostasis2.06960484
28MP0008877_abnormal_DNA_methylation2.05442583
29MP0000013_abnormal_adipose_tissue1.95997366
30MP0003868_abnormal_feces_composition1.95457812
31MP0005646_abnormal_pituitary_gland1.94553769
32MP0005551_abnormal_eye_electrophysiolog1.86978578
33MP0001501_abnormal_sleep_pattern1.83788555
34MP0006072_abnormal_retinal_apoptosis1.81111444
35MP0010386_abnormal_urinary_bladder1.80271952
36MP0005319_abnormal_enzyme/_coenzyme1.77223322
37MP0001502_abnormal_circadian_rhythm1.63081412
38MP0006276_abnormal_autonomic_nervous1.61968753
39MP0001764_abnormal_homeostasis1.60999749
40MP0005584_abnormal_enzyme/coenzyme_acti1.49106305
41MP0009697_abnormal_copulation1.48160770
42MP0000372_irregular_coat_pigmentation1.46236029
43MP0005253_abnormal_eye_physiology1.45961425
44MP0009745_abnormal_behavioral_response1.41061457
45MP0009643_abnormal_urine_homeostasis1.40887928
46MP0004885_abnormal_endolymph1.35481951
47MP0001968_abnormal_touch/_nociception1.32983980
48MP0005451_abnormal_body_composition1.27218273
49MP0001905_abnormal_dopamine_level1.27169943
50MP0003122_maternal_imprinting1.27075896
51MP0002557_abnormal_social/conspecific_i1.26094890
52MP0004147_increased_porphyrin_level1.20020779
53MP0001984_abnormal_olfaction1.19756772
54MP0000598_abnormal_liver_morphology1.14234983
55MP0003186_abnormal_redox_activity1.13901252
56MP0003011_delayed_dark_adaptation1.13439747
57MP0002938_white_spotting1.13346286
58MP0002272_abnormal_nervous_system1.13208326
59MP0003705_abnormal_hypodermis_morpholog1.12821485
60MP0003283_abnormal_digestive_organ1.12408463
61MP0002064_seizures1.11400058
62MP0001986_abnormal_taste_sensitivity1.10494770
63MP0004270_analgesia1.09970493
64MP0003879_abnormal_hair_cell1.09114075
65MP0005084_abnormal_gallbladder_morpholo1.08583218
66MP0003656_abnormal_erythrocyte_physiolo1.08210836
67MP0002572_abnormal_emotion/affect_behav1.07235552
68MP0003172_abnormal_lysosome_physiology1.07124604
69MP0002254_reproductive_system_inflammat1.06974931
70MP0004133_heterotaxia1.04554356
71MP0005174_abnormal_tail_pigmentation1.04132974
72MP0005636_abnormal_mineral_homeostasis1.03108627
73MP0002229_neurodegeneration1.02123661
74MP0005075_abnormal_melanosome_morpholog0.98783196
75MP0005647_abnormal_sex_gland0.97497664
76MP0001970_abnormal_pain_threshold0.97126147
77MP0002090_abnormal_vision0.97085329
78MP0009764_decreased_sensitivity_to0.96915867
79MP0000427_abnormal_hair_cycle0.96395431
80MP0008995_early_reproductive_senescence0.96114802
81MP0000604_amyloidosis0.96032212
82MP0000631_abnormal_neuroendocrine_gland0.94211096
83MP0005410_abnormal_fertilization0.93865796
84MP0002733_abnormal_thermal_nociception0.93844305
85MP0005386_behavior/neurological_phenoty0.93471346
86MP0004924_abnormal_behavior0.93471346
87MP0005220_abnormal_exocrine_pancreas0.93294133
88MP0009763_increased_sensitivity_to0.91615289
89MP0002736_abnormal_nociception_after0.91592535
90MP0001485_abnormal_pinna_reflex0.90970689
91MP0004085_abnormal_heartbeat0.89136127
92MP0005408_hypopigmentation0.87517666
93MP0003633_abnormal_nervous_system0.87158443
94MP0009642_abnormal_blood_homeostasis0.87115882
95MP0002078_abnormal_glucose_homeostasis0.86112459
96MP0000003_abnormal_adipose_tissue0.85932522
97MP0002734_abnormal_mechanical_nocicepti0.85279394
98MP0008469_abnormal_protein_level0.83369743
99MP0002876_abnormal_thyroid_physiology0.82594806
100MP0000569_abnormal_digit_pigmentation0.80585736
101MP0010368_abnormal_lymphatic_system0.77840181
102MP0009765_abnormal_xenobiotic_induced0.77451102
103MP0004142_abnormal_muscle_tone0.77427017
104MP0005376_homeostasis/metabolism_phenot0.75256600
105MP0006036_abnormal_mitochondrial_physio0.74585441
106MP0003121_genomic_imprinting0.73572999
107MP0001756_abnormal_urination0.72912330
108MP0005670_abnormal_white_adipose0.71538542
109MP0000015_abnormal_ear_pigmentation0.71238496
110MP0003045_fibrosis0.70603601
111MP0004264_abnormal_extraembryonic_tissu0.70348748
112MP0005334_abnormal_fat_pad0.68597489
113MP0002971_abnormal_brown_adipose0.67803277
114MP0005535_abnormal_body_temperature0.66292423
115MP0001661_extended_life_span0.66085917
116MP0005448_abnormal_energy_balance0.65757271
117MP0009053_abnormal_anal_canal0.65624528
118MP0004043_abnormal_pH_regulation0.64788130
119MP0005266_abnormal_metabolism0.62833737
120MP0002928_abnormal_bile_duct0.61151360
121MP0004130_abnormal_muscle_cell0.60597850
122MP0010234_abnormal_vibrissa_follicle0.59343976
123MP0002136_abnormal_kidney_physiology0.56989584
124MP0003329_amyloid_beta_deposits0.54926674
125MP0000639_abnormal_adrenal_gland0.54235202
126MP0002822_catalepsy0.52942080
127MP0003690_abnormal_glial_cell0.52694428
128MP0006035_abnormal_mitochondrial_morpho0.50243066
129MP0003638_abnormal_response/metabolism_0.49629914
130MP0005395_other_phenotype0.46965159
131MP0003953_abnormal_hormone_level0.46834213
132MP0004782_abnormal_surfactant_physiolog0.45097966
133MP0009384_cardiac_valve_regurgitation0.44427382
134MP0005464_abnormal_platelet_physiology0.44235938
135MP0003300_gastrointestinal_ulcer0.43556590
136MP0003718_maternal_effect0.43362237
137MP0005248_abnormal_Harderian_gland0.42384525
138MP0002796_impaired_skin_barrier0.41945245
139MP0008873_increased_physiological_sensi0.41112097
140MP0005666_abnormal_adipose_tissue0.40172675
141MP0000579_abnormal_nail_morphology0.39692613
142MP0001765_abnormal_ion_homeostasis0.38489529
143MP0000230_abnormal_systemic_arterial0.37279494
144MP0001944_abnormal_pancreas_morphology0.36809167
145MP0009672_abnormal_birth_weight0.36192181
146MP0005166_decreased_susceptibility_to0.35908582
147MP0000538_abnormal_urinary_bladder0.35705989
148MP0008874_decreased_physiological_sensi0.33983674
149MP0008872_abnormal_physiological_respon0.33094344
150MP0005058_abnormal_lysosome_morphology0.32912535
151MP0002168_other_aberrant_phenotype0.32473205
152MP0002837_dystrophic_cardiac_calcinosis0.32417625
153MP0003724_increased_susceptibility_to0.31657603
154MP0001881_abnormal_mammary_gland0.30984381
155MP0009115_abnormal_fat_cell0.30619669
156MP0003436_decreased_susceptibility_to0.30573213
157MP0003075_altered_response_to0.30114621
158MP0000249_abnormal_blood_vessel0.27823627
159MP0001845_abnormal_inflammatory_respons0.27467140
160MP0002970_abnormal_white_adipose0.27024874
161MP0002060_abnormal_skin_morphology0.26922847

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.34275384
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.03210755
3Deep venous thrombosis (HP:0002625)6.90913375
4Hypobetalipoproteinemia (HP:0003563)6.56039897
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.51145623
6Xanthomatosis (HP:0000991)6.19901596
7Prolonged partial thromboplastin time (HP:0003645)6.15513761
8Complement deficiency (HP:0004431)5.12830063
9Hyperlipoproteinemia (HP:0010980)5.00617488
10Hypolipoproteinemia (HP:0010981)4.77660357
11Epidermoid cyst (HP:0200040)4.59890859
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.57568953
13Hyperammonemia (HP:0001987)4.50687048
14Fat malabsorption (HP:0002630)4.43168863
15Joint hemorrhage (HP:0005261)4.40789199
16Abnormality of the common coagulation pathway (HP:0010990)4.39180672
17Hyperglycinemia (HP:0002154)4.35410430
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.32413121
19Conjugated hyperbilirubinemia (HP:0002908)4.29504939
20Ketosis (HP:0001946)4.25754146
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.17182916
22Hypothermia (HP:0002045)4.16667804
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.09663788
24Hyperglycinuria (HP:0003108)4.09548588
25Abnormal rod and cone electroretinograms (HP:0008323)4.08021030
26Hypoglycemic coma (HP:0001325)4.07046276
27Abnormality of glycine metabolism (HP:0010895)3.99108335
28Abnormality of serine family amino acid metabolism (HP:0010894)3.99108335
29Hypoalphalipoproteinemia (HP:0003233)3.92900900
30Abnormality of methionine metabolism (HP:0010901)3.92039614
31Abnormality of the intrinsic pathway (HP:0010989)3.75692549
32Hypoplasia of the fovea (HP:0007750)3.71658805
33Aplasia/Hypoplasia of the fovea (HP:0008060)3.71658805
34Abnormality of complement system (HP:0005339)3.71531204
35Hypercholesterolemia (HP:0003124)3.63804013
36Hyperventilation (HP:0002883)3.63099800
37Congenital stationary night blindness (HP:0007642)3.62407876
38Abnormality of pyrimidine metabolism (HP:0004353)3.59324403
39Hyperbilirubinemia (HP:0002904)3.35619430
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32704538
41Abnormality of fatty-acid metabolism (HP:0004359)3.30379487
42Limb dystonia (HP:0002451)3.27802621
43Ketoacidosis (HP:0001993)3.24908326
44Abnormality of nucleobase metabolism (HP:0010932)3.20251785
45Acanthocytosis (HP:0001927)3.13892983
46Steatorrhea (HP:0002570)3.08485986
47Mesangial abnormality (HP:0001966)3.07360450
48Abnormality of the renal cortex (HP:0011035)3.03102941
49Delayed CNS myelination (HP:0002188)3.02139950
50Abnormality of purine metabolism (HP:0004352)3.00715476
51Abnormality of the fovea (HP:0000493)2.93371224
52Hepatocellular carcinoma (HP:0001402)2.92338760
53Abnormality of serum amino acid levels (HP:0003112)2.91186883
54Skin nodule (HP:0200036)2.89749301
55Attenuation of retinal blood vessels (HP:0007843)2.87373730
56Myocardial infarction (HP:0001658)2.82798933
57Metabolic acidosis (HP:0001942)2.82132796
58Gout (HP:0001997)2.80904652
59Hypoglycemic seizures (HP:0002173)2.80368030
60Severe visual impairment (HP:0001141)2.79896795
61Spontaneous abortion (HP:0005268)2.77608855
62Hypochromic microcytic anemia (HP:0004840)2.73667434
63Hypomagnesemia (HP:0002917)2.71603475
64Diastasis recti (HP:0001540)2.69934068
65Albinism (HP:0001022)2.62988425
66Nephronophthisis (HP:0000090)2.60482785
67Congenital sensorineural hearing impairment (HP:0008527)2.60081144
68Double outlet right ventricle (HP:0001719)2.58589182
69Congenital malformation of the right heart (HP:0011723)2.58589182
70Systemic lupus erythematosus (HP:0002725)2.58532291
71Malnutrition (HP:0004395)2.58432292
72Vascular calcification (HP:0004934)2.55625096
73Lethargy (HP:0001254)2.54875946
74Intestinal atresia (HP:0011100)2.54030128
75Medial flaring of the eyebrow (HP:0010747)2.53539681
76Pancreatic fibrosis (HP:0100732)2.53150581
77Dicarboxylic aciduria (HP:0003215)2.52104362
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52104362
79Hemiparesis (HP:0001269)2.49581337
80Pancreatic cysts (HP:0001737)2.45273503
81Abnormality of midbrain morphology (HP:0002418)2.41184235
82Molar tooth sign on MRI (HP:0002419)2.41184235
83Abnormal gallbladder morphology (HP:0012437)2.41092525
84Agitation (HP:0000713)2.39729787
85Gaze-evoked nystagmus (HP:0000640)2.39522533
86Bony spicule pigmentary retinopathy (HP:0007737)2.39164628
87Abnormality of macular pigmentation (HP:0008002)2.39014061
88Large for gestational age (HP:0001520)2.38770696
89Spastic diplegia (HP:0001264)2.38361187
90Abnormality of vitamin B metabolism (HP:0004340)2.37090979
91Progressive macrocephaly (HP:0004481)2.36792445
92Irritability (HP:0000737)2.36650997
93Hyperinsulinemic hypoglycemia (HP:0000825)2.35931740
94Late onset (HP:0003584)2.34216308
95Microretrognathia (HP:0000308)2.33676652
96Cholecystitis (HP:0001082)2.33633110
97Abnormal gallbladder physiology (HP:0012438)2.33633110
98Aplasia/Hypoplasia of the macula (HP:0008059)2.32520603
99Glomerulonephritis (HP:0000099)2.31876796
100Cholelithiasis (HP:0001081)2.30916080
101Abnormality of the renal medulla (HP:0100957)2.30855027
102Tubular atrophy (HP:0000092)2.29219874
103Esophageal varix (HP:0002040)2.29154536
104Hydroxyprolinuria (HP:0003080)2.26209780
105Abnormality of proline metabolism (HP:0010907)2.26209780
106Sensorimotor neuropathy (HP:0007141)2.25795365
107Cardiovascular calcification (HP:0011915)2.25616279
108Generalized aminoaciduria (HP:0002909)2.24148640
109Cerebral edema (HP:0002181)2.23740639
110Poikilocytosis (HP:0004447)2.21740821
111Pancreatitis (HP:0001733)2.21106775
112Mitral stenosis (HP:0001718)2.20839010
113Acute necrotizing encephalopathy (HP:0006965)2.17725241
114Neonatal onset (HP:0003623)2.17678294
115Abnormality of magnesium homeostasis (HP:0004921)2.17236235
116Enlarged kidneys (HP:0000105)2.14983419
117Aplasia/Hypoplasia affecting the retina (HP:0008061)2.14187178
118Polydipsia (HP:0001959)2.12822015
119Abnormal drinking behavior (HP:0030082)2.12822015
120Recurrent gram-negative bacterial infections (HP:0005420)2.12094193
121Decreased circulating renin level (HP:0003351)2.10519718
122Mitochondrial inheritance (HP:0001427)2.06971661
123Limb hypertonia (HP:0002509)2.06716550
124Hepatic necrosis (HP:0002605)2.05154421
125Muscular hypotonia of the trunk (HP:0008936)2.05100522
126EEG with generalized epileptiform discharges (HP:0011198)2.04898470
127Amyloidosis (HP:0011034)2.04770304
128Menorrhagia (HP:0000132)2.04146935
129Increased CSF protein (HP:0002922)2.04093859
130Large eyes (HP:0001090)2.03040392
131Vomiting (HP:0002013)2.02751612
132Brushfield spots (HP:0001088)2.02536971
133Gingival bleeding (HP:0000225)2.02274025
134Glycosuria (HP:0003076)2.02029057
135Abnormality of urine glucose concentration (HP:0011016)2.02029057
136Rickets (HP:0002748)2.01769277
137True hermaphroditism (HP:0010459)2.01155753
138Hyperglycemia (HP:0003074)2.01148443
139Symptomatic seizures (HP:0011145)2.01136653
140Hypsarrhythmia (HP:0002521)2.00804399
141Type II lissencephaly (HP:0007260)2.00228959
142Alkalosis (HP:0001948)2.00218655
143Acute encephalopathy (HP:0006846)1.98896943
144Increased CSF lactate (HP:0002490)1.98245034
145Proximal tubulopathy (HP:0000114)1.97238161
146Epileptiform EEG discharges (HP:0011182)1.96734922
147Abnormality of the gallbladder (HP:0005264)1.96437933
148Abnormal enzyme/coenzyme activity (HP:0012379)1.96325783
149Abolished electroretinogram (ERG) (HP:0000550)1.96163150
150Nephrogenic diabetes insipidus (HP:0009806)1.95620014
151Metabolic alkalosis (HP:0200114)1.94823434
152Increased purine levels (HP:0004368)1.94672074
153Hyperuricemia (HP:0002149)1.94672074
154Abnormality of vitamin metabolism (HP:0100508)1.93209151
155Opisthotonus (HP:0002179)1.90130625
156Prominent supraorbital ridges (HP:0000336)1.88515428
157Abnormal cartilage morphology (HP:0002763)1.87950588
158Hemorrhage of the eye (HP:0011885)1.87795529
159Thrombophlebitis (HP:0004418)1.87508475
160Abnormality of endocrine pancreas physiology (HP:0012093)1.87446821
161Abnormality of the pancreatic islet cells (HP:0006476)1.87446821
162Insulin-resistant diabetes mellitus (HP:0000831)1.86675312
163Distal arthrogryposis (HP:0005684)1.85794868
164Renal cortical cysts (HP:0000803)1.84542236
165Abnormal pupillary function (HP:0007686)1.84405937
166Aplasia/hypoplasia of the uterus (HP:0008684)1.83973993
167Congenital primary aphakia (HP:0007707)1.83734841
1683-Methylglutaconic aciduria (HP:0003535)1.82494418
169Arthropathy (HP:0003040)1.81755566
170Gait imbalance (HP:0002141)1.79085523
171Nephrotic syndrome (HP:0000100)1.77804746
172Polyuria (HP:0000103)1.77733139
173Decreased central vision (HP:0007663)1.76889482
174Lipid accumulation in hepatocytes (HP:0006561)1.76855979
175Exocrine pancreatic insufficiency (HP:0001738)1.75412226
176Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74258919
177Protuberant abdomen (HP:0001538)1.72914079
178Furrowed tongue (HP:0000221)1.71854477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.23897260
2ERN14.28582874
3FGFR44.09359497
4SIK14.09292022
5INSRR3.68468778
6TAOK33.62972404
7FRK3.03646415
8ERBB42.91028610
9MST1R2.74000160
10CSNK1G32.56220913
11MST42.29430143
12ADRBK22.28396000
13CSNK1G22.24640604
14PHKG12.23794839
15PHKG22.23794839
16MAP4K22.11455575
17LATS12.11327138
18PIK3CG1.95246503
19ACVR1B1.95017678
20MAP2K41.94866990
21NTRK31.94577557
22PKN21.93577315
23FLT31.92334390
24MAPK111.82534409
25CASK1.81161707
26MAP3K121.80618596
27MAP3K41.76159050
28PTK61.74907275
29TRIB31.49510524
30TYK21.44920694
31PDK21.41935033
32NEK91.39927903
33MAP3K101.36021184
34MAPK151.25808094
35ZAK1.25317274
36MET1.25227772
37FGFR21.24725739
38MAP3K71.24454240
39ABL21.24082236
40GRK61.23979724
41RIPK11.22876751
42PRKAA21.21613728
43PRKCE1.21011927
44JAK21.15986948
45NLK1.12569351
46DAPK21.11585365
47ERBB21.09556466
48OXSR11.09364661
49BMPR1B1.08489161
50TNIK1.06362954
51STK38L1.05080135
52EPHA21.01550025
53KDR0.97887778
54CSNK1A1L0.97777487
55MAP3K30.95377500
56JAK10.93933456
57TBK10.93265823
58EPHB10.93177379
59TRPM70.89242420
60IRAK30.88410703
61MAP3K140.87860703
62TLK10.86103140
63PTK20.84658644
64STK390.83795162
65PRKCZ0.83236505
66PRKCG0.80603401
67EPHA30.80295124
68PINK10.79838077
69PTK2B0.79003342
70DYRK1B0.78748533
71PRKAA10.78570094
72MAP2K30.78478216
73MAPK40.78265040
74PNCK0.77605362
75CAMK2D0.77559648
76MAP3K20.76685681
77GSK3A0.76568737
78HIPK20.74111471
79MUSK0.73292810
80PRKACG0.72019080
81CSNK1A10.70762657
82CAMK1D0.70129944
83CDK60.69036678
84SGK30.68772896
85ERBB30.67977669
86MAPKAPK30.66131219
87CSK0.65661220
88STK160.65497941
89MAPK130.62508257
90PLK20.61628572
91CAMK2G0.61567637
92MAP2K20.61531358
93MAP2K60.61301701
94FGFR30.59837254
95TNK20.59130607
96WNK40.57778083
97AKT30.56953867
98CSNK1D0.55175498
99NUAK10.54271525
100MAP3K110.53095304
101PDPK10.52840022
102PRKCI0.52560481
103MAP3K10.50898587
104MYLK0.50522221
105ADRBK10.50138335
106MAP2K10.47463488
107CSNK1E0.47293652
108MKNK20.46939422
109MAP2K70.46865355
110TIE10.46471721
111PRKG10.45746888
112PRKACA0.45645702
113PRKG20.45304949
114SGK10.45251337
115GRK10.44816899
116WNK30.44774570
117IGF1R0.44671455
118STK240.44659235
119SGK20.44303274
120PRKCQ0.44217102
121IKBKB0.44197688
122MAPK120.43598382
123TRIM280.43582775
124DAPK10.43081042
125ITK0.42581409
126MTOR0.42044338
127RPS6KB10.41794277
128CAMK2A0.41192913
129RET0.40694212
130STK110.39976067
131EIF2AK30.38647158
132MAP3K50.38219611
133CSNK1G10.37483909
134IKBKE0.37207977
135PAK30.37095279
136CDK30.37015450
137SGK4940.36858250
138SGK2230.36858250
139MAPK70.36064851
140TGFBR20.35876547
141PRKCH0.35497590
142PDGFRA0.35480679
143PIK3CA0.34803054
144STK30.33343035
145TXK0.33003885
146PRKD20.32643671
147PDK40.32591490
148PDK30.32591490
149EGFR0.31694122
150PDK10.30945799
151ROCK10.29957320
152CHUK0.29941116
153CSF1R0.29850655
154PRKCA0.28658985
155IRAK10.28639357
156TAOK10.28098690
157FER0.26786955
158ICK0.24881252
159MAP3K130.24309196
160IRAK20.23694551
161CAMK1G0.22492562
162CDK40.21552333

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.31609755
2Nitrogen metabolism_Homo sapiens_hsa009103.63258677
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39240419
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19745147
5Arginine biosynthesis_Homo sapiens_hsa002202.96744606
6Tryptophan metabolism_Homo sapiens_hsa003802.70735552
7Complement and coagulation cascades_Homo sapiens_hsa046102.57217443
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56949990
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54373026
10Fatty acid degradation_Homo sapiens_hsa000712.50011866
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42647827
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39107270
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28480945
14Butanoate metabolism_Homo sapiens_hsa006502.17913215
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10299475
16Peroxisome_Homo sapiens_hsa041462.04367425
17Circadian rhythm_Homo sapiens_hsa047101.94679856
18Histidine metabolism_Homo sapiens_hsa003401.94065567
19Propanoate metabolism_Homo sapiens_hsa006401.90782506
20Insulin secretion_Homo sapiens_hsa049111.87867248
21PPAR signaling pathway_Homo sapiens_hsa033201.86568894
22Caffeine metabolism_Homo sapiens_hsa002321.84638179
23Chemical carcinogenesis_Homo sapiens_hsa052041.84196626
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83506492
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.83287938
26Protein export_Homo sapiens_hsa030601.79425118
27Fatty acid metabolism_Homo sapiens_hsa012121.78158058
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.74489331
29beta-Alanine metabolism_Homo sapiens_hsa004101.72045510
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68715537
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67445821
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66363782
33Retinol metabolism_Homo sapiens_hsa008301.64665957
34Selenocompound metabolism_Homo sapiens_hsa004501.61106292
35Bile secretion_Homo sapiens_hsa049761.60600293
36Sulfur metabolism_Homo sapiens_hsa009201.57690445
37Staphylococcus aureus infection_Homo sapiens_hsa051501.56948624
38Fat digestion and absorption_Homo sapiens_hsa049751.56914257
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51920096
40Phenylalanine metabolism_Homo sapiens_hsa003601.50752651
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49466608
42Starch and sucrose metabolism_Homo sapiens_hsa005001.49335108
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49239174
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.47065719
45Oxidative phosphorylation_Homo sapiens_hsa001901.43940435
46Ether lipid metabolism_Homo sapiens_hsa005651.42697850
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39372180
48Phototransduction_Homo sapiens_hsa047441.38317571
49Pyruvate metabolism_Homo sapiens_hsa006201.37233139
50Tyrosine metabolism_Homo sapiens_hsa003501.34013084
51Folate biosynthesis_Homo sapiens_hsa007901.33223749
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31820453
53ABC transporters_Homo sapiens_hsa020101.28575453
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26194901
55Fatty acid elongation_Homo sapiens_hsa000621.24563907
56Type I diabetes mellitus_Homo sapiens_hsa049401.24110671
57Collecting duct acid secretion_Homo sapiens_hsa049661.20516342
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.18977287
59Vitamin digestion and absorption_Homo sapiens_hsa049771.18817768
60Steroid biosynthesis_Homo sapiens_hsa001001.17025396
61Biosynthesis of amino acids_Homo sapiens_hsa012301.14291948
62Carbon metabolism_Homo sapiens_hsa012001.12769759
63Sphingolipid metabolism_Homo sapiens_hsa006001.09250488
64Serotonergic synapse_Homo sapiens_hsa047261.07217843
65Cyanoamino acid metabolism_Homo sapiens_hsa004601.06067245
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01474017
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98796635
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98242380
69Arginine and proline metabolism_Homo sapiens_hsa003300.98138630
70Amphetamine addiction_Homo sapiens_hsa050310.95084594
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90099416
72Cocaine addiction_Homo sapiens_hsa050300.86665776
73Lysine degradation_Homo sapiens_hsa003100.85677450
74Vitamin B6 metabolism_Homo sapiens_hsa007500.85133210
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83589106
76Renin secretion_Homo sapiens_hsa049240.81755178
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79356668
78Sulfur relay system_Homo sapiens_hsa041220.79335732
79Nicotine addiction_Homo sapiens_hsa050330.78616943
80Glycerolipid metabolism_Homo sapiens_hsa005610.78028841
81GABAergic synapse_Homo sapiens_hsa047270.76117245
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74134067
83Parkinsons disease_Homo sapiens_hsa050120.73911019
84Synaptic vesicle cycle_Homo sapiens_hsa047210.72313184
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71479546
86Glutathione metabolism_Homo sapiens_hsa004800.70382092
87Dopaminergic synapse_Homo sapiens_hsa047280.68490769
88Circadian entrainment_Homo sapiens_hsa047130.66289569
89Cardiac muscle contraction_Homo sapiens_hsa042600.65541688
90One carbon pool by folate_Homo sapiens_hsa006700.64035834
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59305878
92Pentose phosphate pathway_Homo sapiens_hsa000300.56822260
93Alzheimers disease_Homo sapiens_hsa050100.52230817
94Fatty acid biosynthesis_Homo sapiens_hsa000610.51465672
95Galactose metabolism_Homo sapiens_hsa000520.48600324
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46419537
97Basal transcription factors_Homo sapiens_hsa030220.46074321
98Metabolic pathways_Homo sapiens_hsa011000.45497987
99Glutamatergic synapse_Homo sapiens_hsa047240.45431634
100Morphine addiction_Homo sapiens_hsa050320.45073464
101N-Glycan biosynthesis_Homo sapiens_hsa005100.43275461
102Other glycan degradation_Homo sapiens_hsa005110.39771425
103Fructose and mannose metabolism_Homo sapiens_hsa000510.37234066
104Prion diseases_Homo sapiens_hsa050200.31694814
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28973147
106Insulin resistance_Homo sapiens_hsa049310.27131821
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.21560250
108Linoleic acid metabolism_Homo sapiens_hsa005910.21198997
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.19143852
110Renin-angiotensin system_Homo sapiens_hsa046140.17813686
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14344174
112Glucagon signaling pathway_Homo sapiens_hsa049220.11844578
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08743822
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03950296
115AMPK signaling pathway_Homo sapiens_hsa041520.02990156
116Mineral absorption_Homo sapiens_hsa049780.00917078
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2121966
118Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2089795
119Bladder cancer_Homo sapiens_hsa05219-0.1948278
120African trypanosomiasis_Homo sapiens_hsa05143-0.1782562
121Type II diabetes mellitus_Homo sapiens_hsa04930-0.1595760
122Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1557079
123Hepatitis C_Homo sapiens_hsa05160-0.1503007
124Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1469847
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1346737
126Regulation of autophagy_Homo sapiens_hsa04140-0.1303058
127Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1104876
128Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1019001
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0925166
130Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0894370
131Insulin signaling pathway_Homo sapiens_hsa04910-0.0856200
132Protein digestion and absorption_Homo sapiens_hsa04974-0.0537023
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0523866

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