MIB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.23005756
2pore complex assembly (GO:0046931)4.10027759
3paraxial mesoderm development (GO:0048339)4.02949644
4insulin-like growth factor receptor signaling pathway (GO:0048009)3.85925856
5pre-miRNA processing (GO:0031054)3.70291099
6regulation of RNA export from nucleus (GO:0046831)3.55963859
7negative regulation of DNA repair (GO:0045738)3.48070216
8DNA unwinding involved in DNA replication (GO:0006268)3.46064655
9establishment of nucleus localization (GO:0040023)3.42338005
10locomotory exploration behavior (GO:0035641)3.30767358
11sister chromatid segregation (GO:0000819)3.27455024
12regulation of centriole replication (GO:0046599)3.24972358
13synaptic vesicle maturation (GO:0016188)3.19600821
14layer formation in cerebral cortex (GO:0021819)3.09506906
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.09340112
16negative regulation of neurotransmitter secretion (GO:0046929)3.04058240
17mitotic chromosome condensation (GO:0007076)3.03796756
18cytoplasmic mRNA processing body assembly (GO:0033962)2.99968789
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.97509866
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.91455484
21presynaptic membrane assembly (GO:0097105)2.89935052
22synaptic vesicle docking involved in exocytosis (GO:0016081)2.88345423
23DNA topological change (GO:0006265)2.82464254
24regulation of nucleobase-containing compound transport (GO:0032239)2.77442474
25regulation of histone H3-K9 methylation (GO:0051570)2.74280551
26dendrite morphogenesis (GO:0048813)2.73888524
27dendritic spine morphogenesis (GO:0060997)2.70333686
28mitotic sister chromatid segregation (GO:0000070)2.69479544
29neuron projection extension involved in neuron projection guidance (GO:1902284)2.68154851
30axon extension involved in axon guidance (GO:0048846)2.68154851
31morphogenesis of an epithelial sheet (GO:0002011)2.66754330
32glutamate secretion (GO:0014047)2.64699638
33retrograde transport, vesicle recycling within Golgi (GO:0000301)2.64317342
34nerve growth factor signaling pathway (GO:0038180)2.62666526
35establishment of protein localization to Golgi (GO:0072600)2.62045626
36regulation of growth hormone secretion (GO:0060123)2.60734881
37protein targeting to Golgi (GO:0000042)2.60173959
38nucleus localization (GO:0051647)2.60122842
39presynaptic membrane organization (GO:0097090)2.59578333
40vesicle transport along microtubule (GO:0047496)2.59463653
41regulation of transforming growth factor beta2 production (GO:0032909)2.58860562
42regulation of NFAT protein import into nucleus (GO:0051532)2.56332023
43regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.54163946
44notochord development (GO:0030903)2.53493928
45apical protein localization (GO:0045176)2.52678049
46innervation (GO:0060384)2.52175549
47proline transport (GO:0015824)2.51814371
48regulation of dendritic spine morphogenesis (GO:0061001)2.51388657
49negative regulation of fibroblast apoptotic process (GO:2000270)2.50161665
50glucocorticoid receptor signaling pathway (GO:0042921)2.49543418
51embryonic retina morphogenesis in camera-type eye (GO:0060059)2.49348215
52regulation of centrosome duplication (GO:0010824)2.46709976
53regulation of centrosome cycle (GO:0046605)2.46202835
54regulation of sister chromatid cohesion (GO:0007063)2.44899614
55regulation of DNA endoreduplication (GO:0032875)2.43976540
56mitotic sister chromatid cohesion (GO:0007064)2.43724258
57neuronal stem cell maintenance (GO:0097150)2.43586782
58kinetochore organization (GO:0051383)2.42991902
59exocrine pancreas development (GO:0031017)2.42885857
60regulation of glutamate receptor signaling pathway (GO:1900449)2.41472688
61protein localization to chromosome, centromeric region (GO:0071459)2.41286640
62hippo signaling (GO:0035329)2.40887309
63suckling behavior (GO:0001967)2.40766149
64ectodermal placode formation (GO:0060788)2.40313155
65cerebellar Purkinje cell differentiation (GO:0021702)2.40288905
66limb bud formation (GO:0060174)2.40178264
67regulation of clathrin-mediated endocytosis (GO:2000369)2.39449393
68negative regulation of vascular permeability (GO:0043116)2.39083378
69protein localization to kinetochore (GO:0034501)2.38907706
70cytoskeletal anchoring at plasma membrane (GO:0007016)2.37495580
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.37074327
72embryonic camera-type eye morphogenesis (GO:0048596)2.36461128
73convergent extension (GO:0060026)2.35078846
74positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.34737094
75planar cell polarity pathway involved in neural tube closure (GO:0090179)2.34470672
76stress granule assembly (GO:0034063)2.34227578
77DNA duplex unwinding (GO:0032508)2.33763114
78regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.33652072
79regulation of synaptic vesicle exocytosis (GO:2000300)2.33490845
80regulation of axon extension involved in axon guidance (GO:0048841)2.30479868
81regulation of long-term neuronal synaptic plasticity (GO:0048169)2.30214273
82activation of protein kinase A activity (GO:0034199)2.29641793
83sister chromatid cohesion (GO:0007062)2.29394203
84central nervous system projection neuron axonogenesis (GO:0021952)2.29035650
85NLS-bearing protein import into nucleus (GO:0006607)2.28476922
86axon extension (GO:0048675)2.28451293
87negative regulation of translation, ncRNA-mediated (GO:0040033)2.28237095
88regulation of translation, ncRNA-mediated (GO:0045974)2.28237095
89negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.28237095
90positive regulation of muscle hypertrophy (GO:0014742)2.27708130
91positive regulation of cardiac muscle hypertrophy (GO:0010613)2.27708130
92protein localization to microtubule (GO:0035372)2.27078243
93regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.26860769
94axonal fasciculation (GO:0007413)2.26658615
95vocalization behavior (GO:0071625)2.26491836
96negative regulation of histone methylation (GO:0031061)2.26152490
97DNA geometric change (GO:0032392)2.26108088
98genitalia morphogenesis (GO:0035112)2.25565937
99regulation of Rac protein signal transduction (GO:0035020)2.25033773
100membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.24558116
101non-recombinational repair (GO:0000726)2.24263539
102double-strand break repair via nonhomologous end joining (GO:0006303)2.24263539
103positive regulation of dendritic spine morphogenesis (GO:0061003)2.24155566
104regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.24046839
105mitotic spindle organization (GO:0007052)2.22880752
106regulation of ARF protein signal transduction (GO:0032012)2.21818766
107positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.21634314
108positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.21634314
109positive regulation of mitotic sister chromatid separation (GO:1901970)2.21634314
110heterochromatin organization (GO:0070828)2.21387703
111regulation of non-canonical Wnt signaling pathway (GO:2000050)2.20020050
112regulation of neuronal synaptic plasticity (GO:0048168)2.19916711
113midgut development (GO:0007494)2.19224854
114positive regulation of glycogen biosynthetic process (GO:0045725)2.18902255
115negative regulation of sodium ion transport (GO:0010766)2.18645019
116protein localization to synapse (GO:0035418)2.18442198
117clathrin coat assembly (GO:0048268)2.18246665
118regulation of chromosome segregation (GO:0051983)2.17960645
119lateral sprouting from an epithelium (GO:0060601)2.17940593
120body morphogenesis (GO:0010171)2.17849564
121peptidyl-threonine phosphorylation (GO:0018107)2.17380014
122macroautophagy (GO:0016236)2.17017668
123regulation of protein polyubiquitination (GO:1902914)2.16834216
124inner ear receptor cell development (GO:0060119)2.16579968
125peptidyl-threonine modification (GO:0018210)2.16291347
126ATP-dependent chromatin remodeling (GO:0043044)2.16187660
127mitotic cytokinesis (GO:0000281)2.15759330
128microtubule anchoring (GO:0034453)2.15014853
129phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.14156986
130embryonic viscerocranium morphogenesis (GO:0048703)2.14027686
131G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.13775785
132DNA synthesis involved in DNA repair (GO:0000731)2.13718430
133protein localization to microtubule cytoskeleton (GO:0072698)2.12083104
134protein localization to chromosome (GO:0034502)2.12042271
135negative regulation of neurotransmitter transport (GO:0051589)2.11822476
136neuromuscular process controlling balance (GO:0050885)2.11757713
137positive regulation of cell cycle checkpoint (GO:1901978)2.11004440
138neuron recognition (GO:0008038)2.11003201
139gastrulation with mouth forming second (GO:0001702)2.10889961
140spindle checkpoint (GO:0031577)2.10664441
141neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.10498565
142peptidyl-lysine dimethylation (GO:0018027)2.10488196
143positive regulation of catenin import into nucleus (GO:0035413)2.10217381
144asymmetric protein localization (GO:0008105)2.10109286
145dendritic spine organization (GO:0097061)2.09797620
146chemosensory behavior (GO:0007635)2.09522970
147synaptic vesicle exocytosis (GO:0016079)2.09487728
148mesenchymal cell differentiation (GO:0048762)2.08565017
149embryonic body morphogenesis (GO:0010172)2.08548296
150regulation of mitotic sister chromatid separation (GO:0010965)2.08531742
151regulation of mitotic sister chromatid segregation (GO:0033047)2.08531742
152regulation of sister chromatid segregation (GO:0033045)2.08531742
153corticosteroid receptor signaling pathway (GO:0031958)2.08186559
154artery development (GO:0060840)2.08148761
155exploration behavior (GO:0035640)2.07961815
156chondrocyte development (GO:0002063)2.07825213
157nuclear pore complex assembly (GO:0051292)2.07561946
158glial cell proliferation (GO:0014009)2.07134658
159growth hormone receptor signaling pathway (GO:0060396)2.05926470
160regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.05870219
161regulation of axon guidance (GO:1902667)2.04361582
162neurotransmitter secretion (GO:0007269)2.03249260
163regulation of dendritic spine development (GO:0060998)2.01935036
164alanine transport (GO:0032328)2.01757306
165protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.00432530
166monoubiquitinated protein deubiquitination (GO:0035520)1.98934339
167neurotransmitter-gated ion channel clustering (GO:0072578)1.98715620
168dorsal/ventral axis specification (GO:0009950)1.98615258
169positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.98284844
170neuron projection extension (GO:1990138)1.98271054
171embryonic foregut morphogenesis (GO:0048617)1.98197549
172interkinetic nuclear migration (GO:0022027)1.94261190
173histone H3-K9 demethylation (GO:0033169)1.93872889
174cell adhesion mediated by integrin (GO:0033627)1.93153938
175heart morphogenesis (GO:0003007)1.92302321
176regulation of excitatory postsynaptic membrane potential (GO:0060079)1.92243181
177negative regulation of dendrite morphogenesis (GO:0050774)1.92161900
178regulation of synapse structural plasticity (GO:0051823)1.91720767
179organelle transport along microtubule (GO:0072384)1.91247216
180positive regulation of glucose import (GO:0046326)1.91157867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.80240314
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.11305556
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89433298
4KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.74232295
5GBX2_23144817_ChIP-Seq_PC3_Human2.62227443
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.44713677
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40676689
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36746319
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.31119981
10EZH2_22144423_ChIP-Seq_EOC_Human2.28639974
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.21458428
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12289222
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.10175892
14AR_21909140_ChIP-Seq_LNCAP_Human1.94060662
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90096873
16SMAD_19615063_ChIP-ChIP_OVARY_Human1.88140108
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.86856508
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78717340
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78518397
20TP63_19390658_ChIP-ChIP_HaCaT_Human1.78067663
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.71816170
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70853876
23* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69103214
24TP53_16413492_ChIP-PET_HCT116_Human1.68204945
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66886906
26AR_21572438_ChIP-Seq_LNCaP_Human1.66092369
27SMAD4_21799915_ChIP-Seq_A2780_Human1.65445617
28* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61773260
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.59587344
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.58306228
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57842486
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57842486
33AHR_22903824_ChIP-Seq_MCF-7_Human1.57816712
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57502303
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56597604
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55592009
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53520269
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.51344135
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48248145
40* STAT3_23295773_ChIP-Seq_U87_Human1.47972849
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47041119
42DROSHA_22980978_ChIP-Seq_HELA_Human1.43958227
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42218563
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.41899202
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41314303
46* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40664277
47* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40439994
48P300_19829295_ChIP-Seq_ESCs_Human1.40177648
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38244068
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.37690190
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.36265301
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35996657
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35433861
54DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34543333
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.34359956
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.34258545
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.33553197
58SOX9_26525672_Chip-Seq_HEART_Mouse1.32999389
59TAF15_26573619_Chip-Seq_HEK293_Human1.32595933
60YAP1_20516196_ChIP-Seq_MESCs_Mouse1.31885684
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31545670
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31545670
63IGF1R_20145208_ChIP-Seq_DFB_Human1.30982414
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.30871150
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30738432
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.30140625
67STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29174740
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28849292
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.28567358
70* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28417583
71RNF2_27304074_Chip-Seq_NSC_Mouse1.27836851
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.26542631
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.26293271
74TCF4_18268006_ChIP-ChIP_LS174T_Human1.26185922
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25851202
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25806988
77TP53_18474530_ChIP-ChIP_U2OS_Human1.25270608
78FUS_26573619_Chip-Seq_HEK293_Human1.25231186
79AR_19668381_ChIP-Seq_PC3_Human1.25157452
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25100560
81FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24703591
82* TCF4_23295773_ChIP-Seq_U87_Human1.24543410
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24380487
84RXR_22108803_ChIP-Seq_LS180_Human1.23947602
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23375398
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23088996
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22114217
88EGR1_19374776_ChIP-ChIP_THP-1_Human1.21644927
89ZNF274_21170338_ChIP-Seq_K562_Hela1.20614480
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20580544
91TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20256518
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20221396
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19994374
94TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19799290
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19345161
96AR_25329375_ChIP-Seq_VCAP_Human1.18752922
97TRIM28_21343339_ChIP-Seq_HEK293_Human1.17814852
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17768668
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16549722
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15938407
101BCAT_22108803_ChIP-Seq_LS180_Human1.15673601
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14528959
103SOX2_16153702_ChIP-ChIP_HESCs_Human1.13097872
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12673684
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12540447
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.12140659
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12086044
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11730964
109ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10203985
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08703391
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08471572
112CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07978884
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05609348
114FOXA2_19822575_ChIP-Seq_HepG2_Human1.05212851
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04535337
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04473800
117SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03331988
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03184319
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02231148
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01031277
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00363866
122BRD4_25478319_ChIP-Seq_HGPS_Human1.00357510
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.00315360
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99444637
125EWS_26573619_Chip-Seq_HEK293_Human0.98885846
126ELK1_19687146_ChIP-ChIP_HELA_Human0.98671191
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98415526
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98415526
129* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98411727
130GATA1_22025678_ChIP-Seq_K562_Human0.97168720
131RING1B_27294783_Chip-Seq_NPCs_Mouse0.96976359
132NANOG_18555785_Chip-Seq_ESCs_Mouse0.96583403
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96509311
134GF1B_26923725_Chip-Seq_HPCs_Mouse0.94257112
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92302398
136CMYC_18555785_Chip-Seq_ESCs_Mouse0.90817466
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89955288
138NANOG_16153702_ChIP-ChIP_HESCs_Human0.89513954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.64202565
2MP0009780_abnormal_chondrocyte_physiolo3.75585741
3MP0004859_abnormal_synaptic_plasticity3.72658181
4MP0008057_abnormal_DNA_replication3.42457425
5MP0003705_abnormal_hypodermis_morpholog2.86061123
6MP0010234_abnormal_vibrissa_follicle2.68751045
7MP0001299_abnormal_eye_distance/2.35540302
8MP0004270_analgesia2.31940755
9MP0002877_abnormal_melanocyte_morpholog2.22392073
10MP0008438_abnormal_cutaneous_collagen2.18612939
11MP0005623_abnormal_meninges_morphology2.12427519
12MP0003787_abnormal_imprinting1.86835850
13MP0003635_abnormal_synaptic_transmissio1.84593220
14MP0001293_anophthalmia1.84266816
15MP0000537_abnormal_urethra_morphology1.76616995
16MP0003941_abnormal_skin_development1.76611399
17MP0003300_gastrointestinal_ulcer1.73668277
18MP0005409_darkened_coat_color1.73460945
19MP0002009_preneoplasia1.72502033
20MP0003122_maternal_imprinting1.70233869
21MP0001177_atelectasis1.66402397
22MP0005248_abnormal_Harderian_gland1.63524462
23MP0002063_abnormal_learning/memory/cond1.60498712
24* MP0002084_abnormal_developmental_patter1.58654161
25MP0010094_abnormal_chromosome_stability1.57784807
26MP0005187_abnormal_penis_morphology1.57725203
27MP0004272_abnormal_basement_membrane1.56746168
28MP0002938_white_spotting1.56348170
29MP0001286_abnormal_eye_development1.55917927
30MP0009697_abnormal_copulation1.54192864
31MP0002234_abnormal_pharynx_morphology1.51702941
32MP0005503_abnormal_tendon_morphology1.49587251
33MP0004957_abnormal_blastocyst_morpholog1.48747274
34MP0003045_fibrosis1.43865968
35MP0002896_abnormal_bone_mineralization1.43812229
36MP0004858_abnormal_nervous_system1.43283677
37MP0005076_abnormal_cell_differentiation1.42484124
38MP0000778_abnormal_nervous_system1.40691104
39* MP0003861_abnormal_nervous_system1.40180877
40MP0002092_abnormal_eye_morphology1.39972522
41MP0003115_abnormal_respiratory_system1.39832774
42MP0003283_abnormal_digestive_organ1.37463818
43MP0003119_abnormal_digestive_system1.37099871
44MP0003121_genomic_imprinting1.36540715
45MP0003077_abnormal_cell_cycle1.36483912
46MP0009053_abnormal_anal_canal1.35191481
47MP0005171_absent_coat_pigmentation1.34346597
48MP0010678_abnormal_skin_adnexa1.33781059
49* MP0002085_abnormal_embryonic_tissue1.31893741
50MP0003111_abnormal_nucleus_morphology1.30596904
51MP0000516_abnormal_urinary_system1.30086547
52MP0005367_renal/urinary_system_phenotyp1.30086547
53MP0008932_abnormal_embryonic_tissue1.27614437
54MP0006292_abnormal_olfactory_placode1.27128606
55MP0003890_abnormal_embryonic-extraembry1.26611440
56MP0003385_abnormal_body_wall1.25646713
57MP0009384_cardiac_valve_regurgitation1.25168824
58MP0000428_abnormal_craniofacial_morphol1.24807738
59* MP0001672_abnormal_embryogenesis/_devel1.24303013
60* MP0005380_embryogenesis_phenotype1.24303013
61MP0000566_synostosis1.23430259
62MP0002108_abnormal_muscle_morphology1.23113595
63MP0009745_abnormal_behavioral_response1.22080563
64* MP0003984_embryonic_growth_retardation1.21805305
65MP0010307_abnormal_tumor_latency1.20037738
66MP0009046_muscle_twitch1.19955089
67MP0006054_spinal_hemorrhage1.19659976
68* MP0002088_abnormal_embryonic_growth/wei1.19401769
69MP0004197_abnormal_fetal_growth/weight/1.19030040
70MP0005275_abnormal_skin_tensile1.17052942
71MP0002734_abnormal_mechanical_nocicepti1.14955314
72MP0003136_yellow_coat_color1.14469004
73* MP0003935_abnormal_craniofacial_develop1.14154832
74MP0001697_abnormal_embryo_size1.13049192
75MP0001486_abnormal_startle_reflex1.11715194
76MP0005646_abnormal_pituitary_gland1.10628869
77MP0003091_abnormal_cell_migration1.09651746
78MP0000534_abnormal_ureter_morphology1.07934626
79MP0001730_embryonic_growth_arrest1.07207030
80MP0002081_perinatal_lethality1.06576814
81MP0010352_gastrointestinal_tract_polyps1.06366739
82MP0002572_abnormal_emotion/affect_behav1.06263940
83MP0009703_decreased_birth_body1.06062458
84MP0000733_abnormal_muscle_development1.05083477
85MP0000049_abnormal_middle_ear1.04898515
86MP0000762_abnormal_tongue_morphology1.04802110
87* MP0004811_abnormal_neuron_physiology1.04801042
88MP0000350_abnormal_cell_proliferation1.03871017
89MP0005257_abnormal_intraocular_pressure1.03027653
90MP0002909_abnormal_adrenal_gland1.02716133
91MP0003567_abnormal_fetal_cardiomyocyte1.02491380
92* MP0002086_abnormal_extraembryonic_tissu1.02432884
93MP0000955_abnormal_spinal_cord1.00413721
94MP0000013_abnormal_adipose_tissue1.00074330
95MP0002396_abnormal_hematopoietic_system1.00007332
96MP0001879_abnormal_lymphatic_vessel0.99678347
97MP0002064_seizures0.99422424
98MP0003755_abnormal_palate_morphology0.98632339
99MP0003315_abnormal_perineum_morphology0.97462396
100MP0002111_abnormal_tail_morphology0.97108397
101MP0002928_abnormal_bile_duct0.96968766
102MP0010368_abnormal_lymphatic_system0.96608631
103MP0003690_abnormal_glial_cell0.96382112
104MP0004885_abnormal_endolymph0.96238018
105MP0000462_abnormal_digestive_system0.95687483
106MP0000579_abnormal_nail_morphology0.95304537
107MP0009250_abnormal_appendicular_skeleto0.92979569
108MP0003943_abnormal_hepatobiliary_system0.92512379
109MP0002114_abnormal_axial_skeleton0.89980743
110MP0003252_abnormal_bile_duct0.89322632
111MP0002822_catalepsy0.89062844
112MP0003880_abnormal_central_pattern0.88546244
113MP0003632_abnormal_nervous_system0.87226606
114MP0002177_abnormal_outer_ear0.87003518
115MP0001188_hyperpigmentation0.86601682
116MP0003633_abnormal_nervous_system0.86535013
117MP0003942_abnormal_urinary_system0.86249754
118MP0002697_abnormal_eye_size0.86189637
119MP0005391_vision/eye_phenotype0.86115354
120MP0002751_abnormal_autonomic_nervous0.84797966
121MP0003693_abnormal_embryo_hatching0.84364421
122* MP0003937_abnormal_limbs/digits/tail_de0.83981121
123MP0000003_abnormal_adipose_tissue0.83792050
124MP0010030_abnormal_orbit_morphology0.83772207
125MP0003938_abnormal_ear_development0.83103014
126MP0008007_abnormal_cellular_replicative0.81707681
127MP0002089_abnormal_postnatal_growth/wei0.80274772
128MP0001958_emphysema0.80017238
129MP0001915_intracranial_hemorrhage0.79985500
130MP0000432_abnormal_head_morphology0.79969270
131MP0004233_abnormal_muscle_weight0.79605446
132MP0008058_abnormal_DNA_repair0.78620895
133* MP0002080_prenatal_lethality0.78428688
134MP0002233_abnormal_nose_morphology0.77902521
135MP0003123_paternal_imprinting0.77195893
136MP0004808_abnormal_hematopoietic_stem0.76732082
137MP0003631_nervous_system_phenotype0.75158275
138* MP0002152_abnormal_brain_morphology0.74581144
139* MP0002925_abnormal_cardiovascular_devel0.74245102
140MP0002184_abnormal_innervation0.74064778
141MP0004130_abnormal_muscle_cell0.73998175
142MP0001346_abnormal_lacrimal_gland0.73993009
143MP0005167_abnormal_blood-brain_barrier0.73846844
144MP0000383_abnormal_hair_follicle0.73458732
145MP0002557_abnormal_social/conspecific_i0.72355900
146MP0008961_abnormal_basal_metabolism0.71750534
147MP0009672_abnormal_birth_weight0.71592278
148MP0004134_abnormal_chest_morphology0.71039004
149MP0001968_abnormal_touch/_nociception0.70627155
150MP0000631_abnormal_neuroendocrine_gland0.69239260
151MP0002116_abnormal_craniofacial_bone0.68416191

Predicted human phenotypes

RankGene SetZ-score
1Macroorchidism (HP:0000053)3.20639928
2Absent frontal sinuses (HP:0002688)2.82574610
3Subacute progressive viral hepatitis (HP:0006572)2.69332507
4Missing ribs (HP:0000921)2.56558451
5Focal motor seizures (HP:0011153)2.56182690
6Cutaneous finger syndactyly (HP:0010554)2.54515256
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.49486981
8Short 4th metacarpal (HP:0010044)2.49486981
9Increased nuchal translucency (HP:0010880)2.47693449
10Chromsome breakage (HP:0040012)2.46509829
11Aqueductal stenosis (HP:0002410)2.45178587
12Abnormality of the nasal septum (HP:0000419)2.42678735
13Nephroblastoma (Wilms tumor) (HP:0002667)2.40741183
14Cutaneous syndactyly (HP:0012725)2.38600581
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37613662
16Insidious onset (HP:0003587)2.37208642
17Termporal pattern (HP:0011008)2.37208642
18Embryonal renal neoplasm (HP:0011794)2.36692575
19Action tremor (HP:0002345)2.36514693
20Cortical dysplasia (HP:0002539)2.29341171
21Narrow palate (HP:0000189)2.27376567
22Asymmetry of the thorax (HP:0001555)2.25182201
23Buphthalmos (HP:0000557)2.22521128
24Papillary thyroid carcinoma (HP:0002895)2.19733739
25Shallow orbits (HP:0000586)2.19042553
26Vertebral arch anomaly (HP:0008438)2.17736817
27Aplasia/Hypoplasia of the sternum (HP:0006714)2.16947946
28Focal seizures (HP:0007359)2.13155332
29Papilledema (HP:0001085)2.10814144
30Spinal cord lesions (HP:0100561)2.09603553
31Syringomyelia (HP:0003396)2.09603553
32Volvulus (HP:0002580)2.08411124
33Excessive salivation (HP:0003781)2.07807523
34Drooling (HP:0002307)2.07807523
35Genetic anticipation (HP:0003743)2.07455544
36Overgrowth (HP:0001548)2.04750286
37Enlarged penis (HP:0000040)2.03703673
38Coronal craniosynostosis (HP:0004440)2.03167040
39Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.02880486
4011 pairs of ribs (HP:0000878)2.02096978
41Aplasia involving bones of the upper limbs (HP:0009823)2.02054622
42Aplasia of the phalanges of the hand (HP:0009802)2.02054622
43Aplasia involving bones of the extremities (HP:0009825)2.02054622
44High anterior hairline (HP:0009890)2.01251004
45Cerebral aneurysm (HP:0004944)2.00246574
46Exostoses (HP:0100777)1.98212369
47Lower limb amyotrophy (HP:0007210)1.96293119
48Abnormality of the 4th metacarpal (HP:0010012)1.96063687
49Midline defect of the nose (HP:0004122)1.93837975
50Lymphangioma (HP:0100764)1.93278246
51Mitral valve prolapse (HP:0001634)1.92661284
52Aortic aneurysm (HP:0004942)1.92331360
53Urethral obstruction (HP:0000796)1.90794376
54Hepatoblastoma (HP:0002884)1.89953800
55Urinary bladder sphincter dysfunction (HP:0002839)1.89342383
56Cystic hygroma (HP:0000476)1.87814880
57Obsessive-compulsive behavior (HP:0000722)1.87066998
58Impaired vibration sensation in the lower limbs (HP:0002166)1.86373631
59Inappropriate behavior (HP:0000719)1.86088070
60Hypoplastic ischia (HP:0003175)1.85986135
61Hematochezia (HP:0002573)1.85127064
62Abnormality of the frontal sinuses (HP:0002687)1.85006777
63Abnormality of chromosome segregation (HP:0002916)1.83811513
64Curly hair (HP:0002212)1.83747093
65Dysmetric saccades (HP:0000641)1.83744416
66Broad palm (HP:0001169)1.82734570
67Renovascular hypertension (HP:0100817)1.81488401
68Acute myeloid leukemia (HP:0004808)1.81112562
69Abnormality of the antihelix (HP:0009738)1.80392521
70Large earlobe (HP:0009748)1.79977391
71Abnormality of the ischium (HP:0003174)1.79280205
72Malignant gastrointestinal tract tumors (HP:0006749)1.79045283
73Gastrointestinal carcinoma (HP:0002672)1.79045283
74Resting tremor (HP:0002322)1.76990250
75Transitional cell carcinoma of the bladder (HP:0006740)1.76617874
76Medulloblastoma (HP:0002885)1.75251468
77Febrile seizures (HP:0002373)1.75240159
78Progressive cerebellar ataxia (HP:0002073)1.74878626
79Abnormality of the distal phalanx of the thumb (HP:0009617)1.74730844
80Sandal gap (HP:0001852)1.73553548
81Preaxial foot polydactyly (HP:0001841)1.72817638
82Esophageal atresia (HP:0002032)1.72397388
83Ankyloglossia (HP:0010296)1.72204828
84Elfin facies (HP:0004428)1.70763466
85Abnormal lung lobation (HP:0002101)1.68216354
86Overlapping toe (HP:0001845)1.67219175
87Omphalocele (HP:0001539)1.67112706
88Neonatal short-limb short stature (HP:0008921)1.66883813
89Abnormality of the labia majora (HP:0012881)1.66818587
90Vitreoretinal degeneration (HP:0000655)1.66707635
91Diastasis recti (HP:0001540)1.66278463
92Bowel diverticulosis (HP:0005222)1.66167214
93Arnold-Chiari malformation (HP:0002308)1.65283648
94Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63681042
95Blue irides (HP:0000635)1.62861478
96Bladder carcinoma (HP:0002862)1.62428337
97Bladder neoplasm (HP:0009725)1.62428337
98Embryonal neoplasm (HP:0002898)1.62334313
99Deviation of the hallux (HP:0010051)1.61515041
100Rhabdomyosarcoma (HP:0002859)1.61477426
101Renal duplication (HP:0000075)1.61184005
102Heterotopia (HP:0002282)1.60921009
103Truncal obesity (HP:0001956)1.60464822
104Skull defect (HP:0001362)1.59849219
105Abnormality of chromosome stability (HP:0003220)1.59766697
106Hallux valgus (HP:0001822)1.59192182
107Smooth philtrum (HP:0000319)1.59157403
108Abnormality of the calcaneus (HP:0008364)1.58683558
109Arterial tortuosity (HP:0005116)1.58234026
110Gaze-evoked nystagmus (HP:0000640)1.56961563
111Thick eyebrow (HP:0000574)1.55457208
112Pulmonic stenosis (HP:0001642)1.55204027
113Turricephaly (HP:0000262)1.54463919
114Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.54253471
115Myelomeningocele (HP:0002475)1.54245023
116Thyroid carcinoma (HP:0002890)1.53830890
117Duplication of thumb phalanx (HP:0009942)1.53777650
118Pheochromocytoma (HP:0002666)1.53613030
119Exotropia (HP:0000577)1.52965893
120Broad thumb (HP:0011304)1.52644815
121Abnormality of the parietal bone (HP:0002696)1.52571628
122Neoplasm of the adrenal cortex (HP:0100641)1.52235678
123Aneurysm (HP:0002617)1.52153592
124Protrusio acetabuli (HP:0003179)1.51777043
125Cubitus valgus (HP:0002967)1.51547771
126Long clavicles (HP:0000890)1.51313294
127Pointed chin (HP:0000307)1.50701344
128Lower limb asymmetry (HP:0100559)1.50666953
129Overriding aorta (HP:0002623)1.50553968
130Decreased lacrimation (HP:0000633)1.50018764
131Truncal ataxia (HP:0002078)1.49494701
132Relative macrocephaly (HP:0004482)1.49190249
133Hypoplastic labia majora (HP:0000059)1.48288829
134Deeply set eye (HP:0000490)1.48136346
135Hypoplasia of the maxilla (HP:0000327)1.48063999
136Dilatation of the ascending aorta (HP:0005111)1.47953914
137Distal lower limb amyotrophy (HP:0008944)1.47843430
138Ectopic kidney (HP:0000086)1.47470313
139Deep philtrum (HP:0002002)1.47363488
140Absent eyebrow (HP:0002223)1.47269167
141Bell-shaped thorax (HP:0001591)1.46948030
142Intellectual disability, profound (HP:0002187)1.46868560
143Gastrointestinal atresia (HP:0002589)1.46287773
144Vascular tortuosity (HP:0004948)1.46049311
145Cupped ear (HP:0000378)1.46028495
146Short middle phalanx of finger (HP:0005819)1.44953382
147Dental malocclusion (HP:0000689)1.44294697
148Colon cancer (HP:0003003)1.44278498
149Hypospadias (HP:0000047)1.44092190
150Subaortic stenosis (HP:0001682)1.44026364
151Impaired smooth pursuit (HP:0007772)1.43728460
152Uterine leiomyosarcoma (HP:0002891)1.43371056
153Leiomyosarcoma (HP:0100243)1.43371056
154Abnormality of the right ventricle (HP:0001707)1.42703604
155Generalized hypopigmentation of hair (HP:0011358)1.42347587
156Atonic seizures (HP:0010819)1.42284095
157Abnormality of the fingertips (HP:0001211)1.42114889
158Germ cell neoplasia (HP:0100728)1.41697644
159Megalencephaly (HP:0001355)1.40989675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.47711973
2FRK3.23302868
3PNCK2.64299477
4NTRK32.62543610
5RIPK12.41277358
6EPHA42.22820641
7CDC72.03421671
8CAMK1D2.01254117
9FGFR21.98819157
10CAMK1G1.98545980
11INSRR1.97458276
12PDGFRA1.89042871
13MKNK11.86566967
14NUAK11.80787936
15SGK21.77794351
16MAP3K41.74901914
17MAP3K21.73350924
18TNIK1.66540904
19PLK41.65166807
20TTK1.64955138
21KSR11.64298953
22SIK11.64154609
23CAMKK11.63978062
24PRKD31.63682212
25SGK31.63582923
26SCYL21.58887430
27ERBB31.55402971
28DAPK21.52732212
29TAF11.51450401
30STK38L1.49575038
31FGFR31.42878547
32WEE11.42297174
33BRSK21.38665099
34PLK21.37565419
35SRPK11.36566405
36RET1.33427764
37STK31.33034135
38PKN21.31624931
39PBK1.31103822
40NEK21.28326297
41PASK1.25121550
42ICK1.24778513
43CDK121.23814251
44PIK3CA1.23383385
45EIF2AK31.22814895
46NTRK11.21932750
47DMPK1.20573490
48DDR21.20525908
49SGK4941.20407676
50SGK2231.20407676
51MINK11.20090143
52PDGFRB1.19500647
53MAP3K91.18885250
54YES11.18664532
55PTK61.14226584
56MAP2K41.12253599
57AKT31.10085453
58CAMKK21.09316336
59PAK61.06484645
60NLK1.02350695
61PLK31.00525537
62MET0.97802463
63CDK60.96253850
64TRIB30.95899526
65NEK90.94269387
66SGK10.92777012
67FER0.91164485
68FGFR10.89944355
69WNK10.89351947
70TSSK60.88831544
71PRKCH0.87892564
72TTN0.87551869
73ATM0.86022792
74ZAK0.85966037
75SIK20.81999017
76EPHB20.81184934
77STK380.80461488
78WNK30.79690414
79CHEK20.77026196
80STK390.76404327
81MARK10.75431296
82NTRK20.74400820
83NEK60.73760876
84STK240.73517199
85CDK30.73406400
86CDK50.73200224
87TGFBR10.71514778
88MTOR0.71468795
89KSR20.71055754
90BMPR1B0.70224741
91RPS6KB10.69198431
92RPS6KB20.68947444
93EPHA30.66882946
94ATR0.66215715
95DYRK30.65236085
96MAP2K70.64083874
97CHEK10.63375295
98RPS6KA40.62933543
99PLK10.61452942
100BUB10.60893118
101MAPK100.60441607
102ERBB20.60024804
103RPS6KA20.59661765
104PAK30.59213466
105STK110.58517878
106ALK0.58462451
107MELK0.58250588
108PRPF4B0.57945665
109CSNK1G10.57421893
110PTK20.56682416
111CSNK1E0.56662906
112BCR0.56517952
113RPS6KA30.56380189
114EIF2AK20.56218694
115CDK10.54855718
116CAMK40.53820521
117NEK10.53387963
118RAF10.52920254
119LATS20.52408304
120ERBB40.52315285
121CDK20.51556568
122HIPK20.51197957
123TRPM70.51122255
124PRKDC0.50418200
125PRKAA10.49967586
126PDK10.49226948
127EEF2K0.49001749
128RIPK40.48409689
129PIK3CG0.46983907
130TYRO30.45891360
131PTK2B0.45045358
132PDPK10.44550743
133MAP3K60.44329175
134CASK0.44317658
135PRKCE0.44059728
136MKNK20.43809138
137MAP3K100.43171831
138CSNK1A1L0.43076601
139BRD40.42724877
140AURKB0.41369721
141JAK10.40881986
142ROCK10.40472284
143CDK70.40232377
144CSNK1G20.39811003
145LMTK20.39311920
146PAK20.38544280
147DAPK10.38513347

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.40881026
2Non-homologous end-joining_Homo sapiens_hsa034502.09753594
3Cell cycle_Homo sapiens_hsa041102.06526849
4Hedgehog signaling pathway_Homo sapiens_hsa043401.84287148
5mRNA surveillance pathway_Homo sapiens_hsa030151.74840593
6Type II diabetes mellitus_Homo sapiens_hsa049301.70563200
7Long-term potentiation_Homo sapiens_hsa047201.68675376
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65979897
9Glioma_Homo sapiens_hsa052141.62517293
10Thyroid cancer_Homo sapiens_hsa052161.59583252
11Olfactory transduction_Homo sapiens_hsa047401.57991905
12Circadian entrainment_Homo sapiens_hsa047131.47734038
13Insulin secretion_Homo sapiens_hsa049111.44743984
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44652620
15mTOR signaling pathway_Homo sapiens_hsa041501.42890885
16RNA transport_Homo sapiens_hsa030131.37760532
17Amphetamine addiction_Homo sapiens_hsa050311.37373941
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34620761
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33798472
20Glutamatergic synapse_Homo sapiens_hsa047241.33349338
21Endometrial cancer_Homo sapiens_hsa052131.32615483
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32060727
23Dorso-ventral axis formation_Homo sapiens_hsa043201.29191819
24Renin secretion_Homo sapiens_hsa049241.27078368
25Cholinergic synapse_Homo sapiens_hsa047251.26616655
26Dopaminergic synapse_Homo sapiens_hsa047281.25928974
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25837820
28GABAergic synapse_Homo sapiens_hsa047271.24495082
29Fanconi anemia pathway_Homo sapiens_hsa034601.24239923
30Nicotine addiction_Homo sapiens_hsa050331.22484890
31Morphine addiction_Homo sapiens_hsa050321.22294301
32Estrogen signaling pathway_Homo sapiens_hsa049151.20287597
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18482234
34Focal adhesion_Homo sapiens_hsa045101.17514428
35Salivary secretion_Homo sapiens_hsa049701.16130654
36Adherens junction_Homo sapiens_hsa045201.16046212
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15924715
38Gastric acid secretion_Homo sapiens_hsa049711.13548909
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13162537
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12687952
41Oocyte meiosis_Homo sapiens_hsa041141.11985559
42ErbB signaling pathway_Homo sapiens_hsa040121.10332999
43Proteoglycans in cancer_Homo sapiens_hsa052051.09534789
44Oxytocin signaling pathway_Homo sapiens_hsa049211.08087161
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07916462
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07059629
47Selenocompound metabolism_Homo sapiens_hsa004501.06264366
48Basal transcription factors_Homo sapiens_hsa030221.05285122
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05226629
50Mismatch repair_Homo sapiens_hsa034301.05223714
51cAMP signaling pathway_Homo sapiens_hsa040241.04672962
52Axon guidance_Homo sapiens_hsa043601.04283066
53ECM-receptor interaction_Homo sapiens_hsa045121.01574768
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01370373
55Pathways in cancer_Homo sapiens_hsa052001.01048760
56Melanogenesis_Homo sapiens_hsa049160.99711200
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98954134
58Non-small cell lung cancer_Homo sapiens_hsa052230.98907396
59Synaptic vesicle cycle_Homo sapiens_hsa047210.96414172
60Cocaine addiction_Homo sapiens_hsa050300.93985598
61Nucleotide excision repair_Homo sapiens_hsa034200.92326520
62Prostate cancer_Homo sapiens_hsa052150.91621899
63Chronic myeloid leukemia_Homo sapiens_hsa052200.91337293
64Melanoma_Homo sapiens_hsa052180.91181560
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90586265
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.90579169
67Thyroid hormone synthesis_Homo sapiens_hsa049180.90562872
68Dilated cardiomyopathy_Homo sapiens_hsa054140.89987470
69GnRH signaling pathway_Homo sapiens_hsa049120.89584882
70Glucagon signaling pathway_Homo sapiens_hsa049220.89410260
71Insulin resistance_Homo sapiens_hsa049310.89333473
72MicroRNAs in cancer_Homo sapiens_hsa052060.89183303
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88911046
74Long-term depression_Homo sapiens_hsa047300.87495210
75DNA replication_Homo sapiens_hsa030300.87340308
76Gap junction_Homo sapiens_hsa045400.86636600
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.84023795
78p53 signaling pathway_Homo sapiens_hsa041150.83379649
79Rap1 signaling pathway_Homo sapiens_hsa040150.82495469
80Lysine degradation_Homo sapiens_hsa003100.80795659
81Fatty acid biosynthesis_Homo sapiens_hsa000610.80718982
82Colorectal cancer_Homo sapiens_hsa052100.80463456
83Renal cell carcinoma_Homo sapiens_hsa052110.80409031
84Hippo signaling pathway_Homo sapiens_hsa043900.79583802
85Pancreatic secretion_Homo sapiens_hsa049720.78619937
86Spliceosome_Homo sapiens_hsa030400.78406688
87Calcium signaling pathway_Homo sapiens_hsa040200.78100451
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77939227
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77709029
90TGF-beta signaling pathway_Homo sapiens_hsa043500.77602723
91Wnt signaling pathway_Homo sapiens_hsa043100.76902360
92Amoebiasis_Homo sapiens_hsa051460.76758263
93Alcoholism_Homo sapiens_hsa050340.76656418
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76268688
95RNA degradation_Homo sapiens_hsa030180.75355923
96Choline metabolism in cancer_Homo sapiens_hsa052310.75142185
97Steroid biosynthesis_Homo sapiens_hsa001000.74588755
98Pancreatic cancer_Homo sapiens_hsa052120.74301080
99Insulin signaling pathway_Homo sapiens_hsa049100.74193083
100Prolactin signaling pathway_Homo sapiens_hsa049170.73519562
101FoxO signaling pathway_Homo sapiens_hsa040680.73293801
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.72468797
103Taste transduction_Homo sapiens_hsa047420.72380975
104Small cell lung cancer_Homo sapiens_hsa052220.72064570
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70599478
106Circadian rhythm_Homo sapiens_hsa047100.69241856
107Bile secretion_Homo sapiens_hsa049760.68435789
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68199657
109AMPK signaling pathway_Homo sapiens_hsa041520.67754001
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66771255
111Tight junction_Homo sapiens_hsa045300.66517819
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.66237581
113Notch signaling pathway_Homo sapiens_hsa043300.65840283
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65210438
115Basal cell carcinoma_Homo sapiens_hsa052170.65076287
116Platelet activation_Homo sapiens_hsa046110.64783183
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64016462
118Viral carcinogenesis_Homo sapiens_hsa052030.63822502
119Protein digestion and absorption_Homo sapiens_hsa049740.63722720
120Systemic lupus erythematosus_Homo sapiens_hsa053220.62911603
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62815041
122Serotonergic synapse_Homo sapiens_hsa047260.62694136
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62039012
124MAPK signaling pathway_Homo sapiens_hsa040100.61886570
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61766478
126Inositol phosphate metabolism_Homo sapiens_hsa005620.61472234
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56987050
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56512862
129One carbon pool by folate_Homo sapiens_hsa006700.55332781
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52592521
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52472115
132Propanoate metabolism_Homo sapiens_hsa006400.52224627

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