ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA replication-dependent nucleosome assembly (GO:0006335)	7.81916362
2	DNA replication-dependent nucleosome organization (GO:0034723)	7.81916362
3	positive regulation of digestive system process (GO:0060456)	6.52944404
4	innate immune response in mucosa (GO:0002227)	5.66657487
5	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	5.51460688
6	negative regulation of systemic arterial blood pressure (GO:0003085)	5.49064461
7	positive regulation of cardiac muscle cell differentiation (GO:2000727)	5.21438543
8	tryptophan metabolic process (GO:0006568)	5.12667831
9	plasma membrane repair (GO:0001778)	5.12179122
10	mucosal immune response (GO:0002385)	5.08910011
11	pyrimidine dimer repair (GO:0006290)	4.88358224
12	hemidesmosome assembly (GO:0031581)	4.86939030
13	regulation of metalloenzyme activity (GO:0048552)	4.74104291
14	organ or tissue specific immune response (GO:0002251)	4.66058265
15	sequestering of extracellular ligand from receptor (GO:0035581)	4.56074679
16	positive regulation of cAMP-mediated signaling (GO:0043950)	4.44886489
17	negative regulation of multicellular organism growth (GO:0040015)	4.44004783
18	replicative senescence (GO:0090399)	4.37836401
19	positive regulation of systemic arterial blood pressure (GO:0003084)	4.25600465
20	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.24964139
21	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.23217932
22	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.23217932
23	transcription elongation from RNA polymerase I promoter (GO:0006362)	4.15585749
24	desmosome organization (GO:0002934)	4.14791326
25	antibacterial humoral response (GO:0019731)	4.13418002
26	positive regulation of muscle hypertrophy (GO:0014742)	4.12929855
27	positive regulation of cardiac muscle hypertrophy (GO:0010613)	4.12929855
28	tyrosine metabolic process (GO:0006570)	4.08424414
29	antimicrobial humoral response (GO:0019730)	4.02101835
30	extracellular matrix assembly (GO:0085029)	3.99300124
31	positive regulation of heart rate (GO:0010460)	3.98301322
32	adrenergic receptor signaling pathway (GO:0071875)	3.92826190
33	epithelial cell differentiation involved in kidney development (GO:0035850)	3.84675270
34	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.70727146
35	indolalkylamine metabolic process (GO:0006586)	3.66100305
36	regulation of cardiac muscle cell contraction (GO:0086004)	3.60512667
37	cardiac muscle hypertrophy in response to stress (GO:0014898)	3.60088321
38	muscle hypertrophy in response to stress (GO:0003299)	3.60088321
39	cardiac muscle adaptation (GO:0014887)	3.60088321
40	negative regulation of smooth muscle contraction (GO:0045986)	3.54075929
41	nucleosome assembly (GO:0006334)	3.47800130
42	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.36085159
43	striated muscle atrophy (GO:0014891)	3.28248723
44	mesonephros development (GO:0001823)	3.27124614
45	cytidine deamination (GO:0009972)	3.27075744
46	cytidine metabolic process (GO:0046087)	3.27075744
47	cytidine catabolic process (GO:0006216)	3.27075744
48	sulfation (GO:0051923)	3.26954462
49	negative regulation of peptidyl-lysine acetylation (GO:2000757)	3.23648696
50	negative regulation of mast cell activation (GO:0033004)	3.21060514
51	positive regulation of cardiac muscle tissue growth (GO:0055023)	3.19543520
52	forebrain neuron development (GO:0021884)	3.19336624
53	tryptophan catabolic process (GO:0006569)	3.16220575
54	indole-containing compound catabolic process (GO:0042436)	3.16220575
55	indolalkylamine catabolic process (GO:0046218)	3.16220575
56	T-helper cell differentiation (GO:0042093)	3.13980019
57	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	3.13980019
58	norepinephrine metabolic process (GO:0042415)	3.11923914
59	striated muscle adaptation (GO:0014888)	3.09637588
60	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	3.08585604
61	kynurenine metabolic process (GO:0070189)	3.05007300
62	cell differentiation involved in embryonic placenta development (GO:0060706)	3.01896183
63	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.99779628
64	muscle atrophy (GO:0014889)	2.99143776
65	regulation of hippo signaling (GO:0035330)	2.98679062
66	intestinal cholesterol absorption (GO:0030299)	2.98269897
67	protein-DNA complex assembly (GO:0065004)	2.97102535
68	response to oxygen radical (GO:0000305)	2.95475775
69	trophoblast giant cell differentiation (GO:0060707)	2.95165157
70	pharyngeal system development (GO:0060037)	2.94601855
71	heparin metabolic process (GO:0030202)	2.94263600
72	heparin biosynthetic process (GO:0030210)	2.94263600
73	regulation of cell proliferation involved in kidney development (GO:1901722)	2.93852411
74	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.91962460
75	response to superoxide (GO:0000303)	2.91489364
76	regulation of cardiac muscle hypertrophy (GO:0010611)	2.86354688
77	protein prenylation (GO:0018342)	2.85610736
78	prenylation (GO:0097354)	2.85610736
79	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.84516479
80	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.84516479
81	regulation of cardiac muscle cell differentiation (GO:2000725)	2.83025027
82	regulation of muscle hypertrophy (GO:0014743)	2.81731089
83	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.80481525
84	pattern specification involved in kidney development (GO:0061004)	2.78998759
85	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.78730903
86	regulation of somitogenesis (GO:0014807)	2.76819319
87	peptidyl-proline hydroxylation (GO:0019511)	2.76803095
88	regulation of megakaryocyte differentiation (GO:0045652)	2.73937859
89	endocardial cushion development (GO:0003197)	2.72072859
90	response to UV-C (GO:0010225)	2.69072004
91	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.68021463
92	alpha-beta T cell activation involved in immune response (GO:0002287)	2.68021463
93	T cell differentiation involved in immune response (GO:0002292)	2.68021463
94	glycoprotein biosynthetic process (GO:0009101)	2.67738908
95	negative regulation of protein acetylation (GO:1901984)	2.67666049
96	termination of RNA polymerase I transcription (GO:0006363)	2.67115503
97	cardiac muscle hypertrophy (GO:0003300)	2.66719095
98	positive regulation of heart growth (GO:0060421)	2.64160056
99	molting cycle (GO:0042303)	10.2315298
100	hair cycle (GO:0042633)	10.2315298

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	8.09174337
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.27332167
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.63878790
4	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.59195551
5	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.39963252
6	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.23180960
7	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.01254040
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	18.1954119
9	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.98709313
10	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.84604920
11	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.80353729
12	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.54333806
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.47224923
14	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.43352694
15	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.42712168
16	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.40763530
17	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.39801860
18	AHR_22903824_ChIP-Seq_MCF-7_Human	1.38734910
19	* TP53_16413492_ChIP-PET_HCT116_Human	1.36324794
20	GATA1_22025678_ChIP-Seq_K562_Human	1.34238996
21	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.33066386
22	* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.32454458
23	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.30813643
24	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.30813643
25	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.26782122
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26159245
27	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.17880903
28	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.12823615
29	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.10691506
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05960277
31	* CJUN_26792858_Chip-Seq_BT549_Human	1.05639982
32	ZNF274_21170338_ChIP-Seq_K562_Hela	1.01230235
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99060627
34	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.98903538
35	* NANOG_16153702_ChIP-ChIP_HESCs_Human	0.98214495
36	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.96319467
37	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.96163107
38	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.95033420
39	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.94341276
40	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.92685562
41	BRD4_25478319_ChIP-Seq_HGPS_Human	0.91535032
42	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.91306600
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.90548070
44	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.86907746
45	VDR_23849224_ChIP-Seq_CD4+_Human	0.84307241
46	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.83284345
47	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.83087643
48	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.82995196
49	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.82487804
50	ER_23166858_ChIP-Seq_MCF-7_Human	0.81050862
51	FUS_26573619_Chip-Seq_HEK293_Human	0.78180243
52	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.77622478
53	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.73777529
54	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.73457285
55	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.71759171
56	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.71115145
57	GATA4_25053715_ChIP-Seq_YYC3_Human	0.71054758
58	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.69858389
59	GATA6_25053715_ChIP-Seq_YYC3_Human	0.69388025
60	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.67404472
61	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.66043880
62	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.65198288
63	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.64451444
64	* PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.64341162
65	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.64276975
66	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.64030808
67	AR_21909140_ChIP-Seq_LNCAP_Human	0.63051156
68	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.61448534
69	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.61315860
70	ETS1_22383799_ChIP-Seq_G1ME_Mouse	0.61274619
71	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.59917816
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.58757882
73	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.56938612
74	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.56860914
75	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.56632102
76	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.55991772
77	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.55861576
78	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.54110961
79	* TP53_18474530_ChIP-ChIP_U2OS_Human	0.53198067
80	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.53035265
81	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.53023292
82	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.52449386
83	SOX2_18692474_ChIP-Seq_MESCs_Mouse	0.51333353
84	SOX2_20726797_ChIP-Seq_SW620_Human	0.50517866
85	* EWS_26573619_Chip-Seq_HEK293_Human	0.49934441
86	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.48200543
87	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.47911019
88	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.47545640
89	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.47250372
90	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.46413907
91	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.46002463
92	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.45522141
93	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.45495800
94	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.44117877
95	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.43969844
96	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.43495066
97	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.43495066
98	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.43349474
99	STAT3_23295773_ChIP-Seq_U87_Human	0.42629080
100	MYC_18940864_ChIP-ChIP_HL60_Human	0.42386887

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008438_abnormal_cutaneous_collagen	7.62159771
2	MP0005275_abnormal_skin_tensile	6.21258277
3	MP0005171_absent_coat_pigmentation	5.10664242
4	MP0005083_abnormal_biliary_tract	3.62954146
5	MP0005503_abnormal_tendon_morphology	3.45894741
6	MP0000569_abnormal_digit_pigmentation	3.43033526
7	MP0003950_abnormal_plasma_membrane	3.11368631
8	MP0002060_abnormal_skin_morphology	3.02966865
9	MP0009697_abnormal_copulation	2.98946429
10	MP0001243_abnormal_dermal_layer	2.92308731
11	MP0003279_aneurysm	2.41890148
12	MP0002138_abnormal_hepatobiliary_system	2.23788410
13	MP0000383_abnormal_hair_follicle	2.14586792
14	MP0001958_emphysema	2.10672553
15	MP0004134_abnormal_chest_morphology	1.99982052
16	MP0000372_irregular_coat_pigmentation	1.91014305
17	MP0002295_abnormal_pulmonary_circulatio	1.88733838
18	MP0002160_abnormal_reproductive_system	1.87392182
19	MP0009384_cardiac_valve_regurgitation	1.82302498
20	MP0001216_abnormal_epidermal_layer	1.76009805
21	MP0002282_abnormal_trachea_morphology	1.69002998
22	MP0005023_abnormal_wound_healing	1.66319196
23	MP0002166_altered_tumor_susceptibility	1.60164353
24	MP0002933_joint_inflammation	1.55822701
25	MP0000371_diluted_coat_color	1.53419706
26	MP0008872_abnormal_physiological_respon	1.53307147
27	MP0000003_abnormal_adipose_tissue	1.50064466
28	MP0002163_abnormal_gland_morphology	1.39578779
29	MP0003195_calcinosis	1.39161496
30	MP0003786_premature_aging	1.38499734
31	MP0004272_abnormal_basement_membrane	1.36225503
32	MP0003705_abnormal_hypodermis_morpholog	1.35175823
33	MP0001191_abnormal_skin_condition	1.35064126
34	MP0010771_integument_phenotype	1.34090692
35	MP0005389_reproductive_system_phenotype	1.31567590
36	MP0010678_abnormal_skin_adnexa	1.28458592
37	MP0002006_tumorigenesis	1.20460263
38	MP0002139_abnormal_hepatobiliary_system	1.16858269
39	MP0010386_abnormal_urinary_bladder	1.14459013
40	MP0004381_abnormal_hair_follicle	1.13264216
41	MP0000427_abnormal_hair_cycle	1.11849883
42	MP0000762_abnormal_tongue_morphology	1.08502731
43	MP0010094_abnormal_chromosome_stability	1.08332337
44	MP0003183_abnormal_peptide_metabolism	0.99246924
45	MP0000163_abnormal_cartilage_morphology	0.99174080
46	MP0000358_abnormal_cell_content/	0.99074920
47	MP0005076_abnormal_cell_differentiation	0.94634445
48	MP0008057_abnormal_DNA_replication	0.93834179
49	MP0002876_abnormal_thyroid_physiology	0.92827525
50	MP0002108_abnormal_muscle_morphology	0.92065627
51	MP0001879_abnormal_lymphatic_vessel	0.91051418
52	MP0000013_abnormal_adipose_tissue	0.87970607
53	MP0001764_abnormal_homeostasis	0.86121269
54	MP0003941_abnormal_skin_development	0.85904247
55	MP0000367_abnormal_coat/_hair	0.85680106
56	MP0006054_spinal_hemorrhage	0.83919516
57	MP0002971_abnormal_brown_adipose	0.83117967
58	MP0009764_decreased_sensitivity_to	0.82177767
59	MP0002332_abnormal_exercise_endurance	0.81518712
60	MP0002254_reproductive_system_inflammat	0.80697714
61	MP0000538_abnormal_urinary_bladder	0.76016629
62	MP0009250_abnormal_appendicular_skeleto	0.75840616
63	MP0004264_abnormal_extraembryonic_tissu	0.74662137
64	MP0005508_abnormal_skeleton_morphology	0.74611752
65	MP0003868_abnormal_feces_composition	0.73962928
66	MP0004947_skin_inflammation	0.70999600
67	MP0000639_abnormal_adrenal_gland	0.69180845
68	MP0003638_abnormal_response/metabolism_	0.68812165
69	MP0000733_abnormal_muscle_development	0.68000762
70	MP0003252_abnormal_bile_duct	0.67791038
71	MP0003959_abnormal_lean_body	0.66764391
72	MP0003453_abnormal_keratinocyte_physiol	0.66371062
73	MP0002075_abnormal_coat/hair_pigmentati	0.64592727
74	MP0005410_abnormal_fertilization	0.64036436
75	MP0009053_abnormal_anal_canal	0.63970464
76	MP0008007_abnormal_cellular_replicative	0.60740008
77	MP0001919_abnormal_reproductive_system	0.59706432
78	MP0001542_abnormal_bone_strength	0.59637696
79	MP0001666_abnormal_nutrient_absorption	0.59388657
80	MP0009931_abnormal_skin_appearance	0.58470241
81	MP0005501_abnormal_skin_physiology	0.57349100
82	MP0009115_abnormal_fat_cell	0.56990214
83	MP0003566_abnormal_cell_adhesion	0.56938253
84	MP0000767_abnormal_smooth_muscle	0.55522904
85	MP0003942_abnormal_urinary_system	0.54856259
86	MP0004142_abnormal_muscle_tone	0.54201957
87	MP0005379_endocrine/exocrine_gland_phen	0.53978114
88	MP0001348_abnormal_lacrimal_gland	0.52886281
89	MP0005388_respiratory_system_phenotype	0.52356035
90	MP0002133_abnormal_respiratory_system	0.52356035
91	MP0002135_abnormal_kidney_morphology	0.51301134
92	MP0002928_abnormal_bile_duct	0.51225108
93	MP0000613_abnormal_salivary_gland	0.50814667
94	MP0009780_abnormal_chondrocyte_physiolo	0.50725073
95	MP0002115_abnormal_skeleton_extremities	0.50582700
96	MP0001175_abnormal_lung_morphology	0.50528259
97	MP0005334_abnormal_fat_pad	0.50206864
98	MP0002136_abnormal_kidney_physiology	0.50011549
99	MP0008058_abnormal_DNA_repair	0.47516158
100	MP0002109_abnormal_limb_morphology	0.46500496

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Neoplasm of the heart (HP:0100544)	7.91959398
2	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	7.10471206
3	Short 4th metacarpal (HP:0010044)	7.10471206
4	Milia (HP:0001056)	6.50994106
5	Deformed sella turcica (HP:0002681)	6.48751459
6	Down-sloping shoulders (HP:0200021)	6.01442118
7	Abnormality of the parietal bone (HP:0002696)	5.93492193
8	Short phalanx of the thumb (HP:0009660)	5.27945726
9	Medulloblastoma (HP:0002885)	5.13183236
10	Abnormality of the 4th metacarpal (HP:0010012)	4.99214359
11	Abnormality of the sella turcica (HP:0002679)	4.84911655
12	Abnormality of the distal phalanx of the thumb (HP:0009617)	4.50778597
13	Supernumerary ribs (HP:0005815)	4.30783256
14	Abnormality of the renal collecting system (HP:0004742)	4.13134431
15	Supernumerary bones of the axial skeleton (HP:0009144)	4.12267962
16	Neoplasm of the oral cavity (HP:0100649)	4.11001141
17	Duplicated collecting system (HP:0000081)	3.97731613
18	Entropion (HP:0000621)	3.96255578
19	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	3.86753142
20	Abnormal hand bone ossification (HP:0010660)	3.82554621
21	Hypoplastic pelvis (HP:0008839)	3.73857905
22	Abnormality of DNA repair (HP:0003254)	3.73489815
23	Abnormal ossification of hand bones (HP:0005921)	3.59367329
24	Cerebellar dysplasia (HP:0007033)	3.54317052
25	Neoplasm of striated muscle (HP:0009728)	3.45815417
26	Soft skin (HP:0000977)	3.26477378
27	Vertebral fusion (HP:0002948)	3.26358817
28	Oral leukoplakia (HP:0002745)	3.23160576
29	Arterial tortuosity (HP:0005116)	3.13000900
30	Broad ribs (HP:0000885)	3.11523091
31	Basal cell carcinoma (HP:0002671)	3.11007886
32	Hemivertebrae (HP:0002937)	3.00698656
33	Vascular tortuosity (HP:0004948)	2.76174803
34	Hypothermia (HP:0002045)	2.64465179
35	Abnormal auditory evoked potentials (HP:0006958)	2.63267416
36	Poikiloderma (HP:0001029)	2.62328053
37	Concave nail (HP:0001598)	2.60264734
38	Dry hair (HP:0011359)	2.59590307
39	Reduced subcutaneous adipose tissue (HP:0003758)	2.52770150
40	IgA deficiency (HP:0002720)	2.48768221
41	Ureteral duplication (HP:0000073)	2.46871382
42	Hamartoma (HP:0010566)	2.44886726
43	Hypoplasia of the pons (HP:0012110)	2.38857877
44	Type II lissencephaly (HP:0007260)	2.35430604
45	Skin pits (HP:0100276)	2.32350776
46	Sensory axonal neuropathy (HP:0003390)	2.32144468
47	Abnormality of the pons (HP:0007361)	2.30192294
48	Death in childhood (HP:0003819)	2.29351740
49	Kyphoscoliosis (HP:0002751)	2.24550319
50	Short thumb (HP:0009778)	2.24096566
51	Right ventricular cardiomyopathy (HP:0011663)	2.17483611
52	Spinal muscular atrophy (HP:0007269)	2.13260868
53	Fibroma (HP:0010614)	2.07626716
54	Woolly hair (HP:0002224)	2.05583421
55	Short ribs (HP:0000773)	2.04595578
56	Rough bone trabeculation (HP:0100670)	2.04482831
57	Prominent nose (HP:0000448)	2.03089608
58	Increased corneal curvature (HP:0100692)	2.03042261
59	Keratoconus (HP:0000563)	2.03042261
60	Fibrous tissue neoplasm (HP:0012316)	2.00118359
61	Atrophic scars (HP:0001075)	1.95746530
62	Ectropion (HP:0000656)	1.95014795
63	Hypoplasia of the iris (HP:0007676)	1.90538121
64	Increased connective tissue (HP:0009025)	1.90505259
65	Abnormality of the carotid arteries (HP:0005344)	1.90001618
66	Onycholysis (HP:0001806)	1.89547534
67	Ureteral obstruction (HP:0006000)	1.87881253
68	Abnormality of the odontoid process (HP:0003310)	1.85750573
69	Flat acetabular roof (HP:0003180)	1.82454266
70	Redundant skin (HP:0001582)	1.81866737
71	Striae distensae (HP:0001065)	1.80478000
72	Sloping forehead (HP:0000340)	1.78315803
73	Natal tooth (HP:0000695)	1.78065510
74	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.76974197
75	Hypoplastic iliac wings (HP:0002866)	1.76202235
76	Sprengel anomaly (HP:0000912)	1.74207906
77	Short nail (HP:0001799)	1.74012846
78	Coxa valga (HP:0002673)	1.73726986
79	Wormian bones (HP:0002645)	1.73559799
80	Severe short stature (HP:0003510)	1.73378883
81	Abnormality of the pulmonary veins (HP:0011718)	1.71724577
82	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.71705210
83	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.71271413
84	Aortic regurgitation (HP:0001659)	1.71250516
85	Abnormality of the preputium (HP:0100587)	1.65778583
86	Dilatation of the ascending aorta (HP:0005111)	1.65711028
87	Thickened calvaria (HP:0002684)	1.65169029
88	Abnormality of chromosome stability (HP:0003220)	1.65132824
89	Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)	1.64832229
90	Pendular nystagmus (HP:0012043)	1.64219397
91	Spontaneous hematomas (HP:0007420)	1.62963651
92	Abnormality of the nasal septum (HP:0000419)	1.62823948
93	Anomalous pulmonary venous return (HP:0010772)	1.61930860
94	Cardiovascular calcification (HP:0011915)	1.59326320
95	3-Methylglutaconic aciduria (HP:0003535)	1.59277756
96	Tubular atrophy (HP:0000092)	1.58475501
97	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.58081770
98	Skin tags (HP:0010609)	1.56581342
99	Abnormal trabecular bone morphology (HP:0100671)	1.55734808
100	Wide intermamillary distance (HP:0006610)	1.55666448

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	7.19488406
2	ZAK	7.02718361
3	VRK1	4.39325156
4	PBK	2.61830481
5	DAPK3	2.58789795
6	RPS6KA5	2.57786630
7	ADRBK2	2.19978331
8	STK4	2.18217089
9	MST4	2.11655459
10	MST1R	2.09419344
11	EPHA2	1.86320161
12	FRK	1.76827115
13	EPHA3	1.63329339
14	EIF2AK3	1.57827462
15	NEK9	1.55928529
16	PRKCI	1.51109759
17	DAPK2	1.50011370
18	ACVR1B	1.48160966
19	MAP3K4	1.41051764
20	BUB1	1.36805727
21	PKN2	1.35091738
22	MAP2K7	1.34727543
23	MAPKAPK5	1.33230964
24	MET	1.27107817
25	BMPR1B	1.24942548
26	MAP2K4	1.24354323
27	LATS1	1.20473129
28	GRK1	1.19575924
29	AURKA	1.18762649
30	TAF1	1.18488162
31	BRSK2	1.14513949
32	AKT3	1.12002076
33	MAP3K12	1.10546953
34	WNK1	1.09959846
35	NME2	1.08443441
36	PKN1	1.02563396
37	PTK2B	1.01772064
38	AURKB	0.98217871
39	PLK4	0.97154603
40	TRPM7	0.96372270
41	FLT3	0.95877113
42	MAP3K8	0.93101741
43	STK38L	0.91254289
44	MAP2K3	0.90289401
45	MELK	0.89908464
46	PIM1	0.85652041
47	IKBKB	0.85641587
48	PRKCH	0.82144978
49	PRKAA1	0.79500059
50	ADRBK1	0.78080503
51	GRK7	0.64337857
52	MAPK11	0.63412042
53	PDGFRB	0.63321040
54	MYLK	0.62921452
55	PRKCQ	0.61028298
56	MAP3K6	0.59038470
57	CHEK2	0.55839943
58	CSNK1A1L	0.54542550
59	STK24	0.54217502
60	CAMK4	0.49659939
61	STK16	0.49119421
62	CCNB1	0.46508277
63	BTK	0.45937205
64	TGFBR2	0.45681030
65	STK3	0.45643848
66	MAP2K6	0.44299716
67	ABL2	0.41918541
68	TAOK3	0.40998406
69	PTK2	0.39027732
70	CHUK	0.38072014
71	BLK	0.37548310
72	PINK1	0.37254801
73	NLK	0.37138120
74	MAP3K3	0.36314296
75	SCYL2	0.36082149
76	RPS6KA6	0.35888755
77	AKT2	0.35428818
78	STK38	0.34974730
79	CAMKK2	0.34684332
80	PIM2	0.33996096
81	PRKCE	0.33509573
82	BRAF	0.29580660
83	MAP3K11	0.28107687
84	RET	0.25808808
85	MUSK	0.25402561
86	SIK1	0.25312976
87	NEK6	0.25013771
88	RPS6KL1	0.22333519
89	RPS6KC1	0.22333519
90	WEE1	0.22127888
91	BRD4	0.22126365
92	RPS6KA2	0.20290846
93	DAPK1	0.19651858
94	MAP2K1	0.19264947
95	MARK3	0.18402706
96	ABL1	0.16460545
97	MAPKAPK3	0.15684712
98	FER	0.15648828
99	NUAK1	0.14694319
100	NEK2	0.13946027

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Alcoholism_Homo sapiens_hsa05034	7.15632496
2	Viral carcinogenesis_Homo sapiens_hsa05203	3.64027346
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.32217976
4	Basal cell carcinoma_Homo sapiens_hsa05217	2.27126290
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.19711444
6	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.09161776
7	Systemic lupus erythematosus_Homo sapiens_hsa05322	10.1216518
8	Selenocompound metabolism_Homo sapiens_hsa00450	1.74375984
9	Fanconi anemia pathway_Homo sapiens_hsa03460	1.47915933
10	Nucleotide excision repair_Homo sapiens_hsa03420	1.46750874
11	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.36947119
12	ECM-receptor interaction_Homo sapiens_hsa04512	1.35536336
13	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.35504047
14	Homologous recombination_Homo sapiens_hsa03440	1.34574908
15	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.32458265
16	Protein digestion and absorption_Homo sapiens_hsa04974	1.26523497
17	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.22890095
18	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.11244224
19	Pancreatic secretion_Homo sapiens_hsa04972	1.08700434
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.07687105
21	Melanoma_Homo sapiens_hsa05218	1.00494639
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.98166542
23	p53 signaling pathway_Homo sapiens_hsa04115	0.94967679
24	Small cell lung cancer_Homo sapiens_hsa05222	0.87923854
25	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.79190362
26	Bladder cancer_Homo sapiens_hsa05219	0.77726615
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.73523532
28	Basal transcription factors_Homo sapiens_hsa03022	0.73248131
29	Tryptophan metabolism_Homo sapiens_hsa00380	0.72278412
30	Fat digestion and absorption_Homo sapiens_hsa04975	0.71803821
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.70764754
32	Primary immunodeficiency_Homo sapiens_hsa05340	0.68808801
33	TNF signaling pathway_Homo sapiens_hsa04668	0.64535748
34	Sphingolipid metabolism_Homo sapiens_hsa00600	0.63524498
35	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.62478929
36	One carbon pool by folate_Homo sapiens_hsa00670	0.62355650
37	Pathways in cancer_Homo sapiens_hsa05200	0.62298790
38	RNA polymerase_Homo sapiens_hsa03020	0.60642285
39	Sulfur metabolism_Homo sapiens_hsa00920	0.58222375
40	Focal adhesion_Homo sapiens_hsa04510	0.57002286
41	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56158895
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.56044782
43	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55693108
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52274907
45	Proteoglycans in cancer_Homo sapiens_hsa05205	0.51613103
46	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.50738089
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47665705
48	MicroRNAs in cancer_Homo sapiens_hsa05206	0.47653454
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.47240811
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.43835326
51	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43741681
52	Oxidative phosphorylation_Homo sapiens_hsa00190	0.41571452
53	Mineral absorption_Homo sapiens_hsa04978	0.41303781
54	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.39665959
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36943822
56	HTLV-I infection_Homo sapiens_hsa05166	0.35956719
57	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.35097753
58	Regulation of autophagy_Homo sapiens_hsa04140	0.34694595
59	DNA replication_Homo sapiens_hsa03030	0.34316331
60	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.33981449
61	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.33104304
62	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.32715033
63	Hippo signaling pathway_Homo sapiens_hsa04390	0.31021959
64	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.30743542
65	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.29026704
66	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.27763131
67	Linoleic acid metabolism_Homo sapiens_hsa00591	0.27393630
68	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.27345384
69	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.27001541
70	Circadian rhythm_Homo sapiens_hsa04710	0.26780026
71	Lysosome_Homo sapiens_hsa04142	0.26678451
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.26099965
73	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.25865974
74	Cell cycle_Homo sapiens_hsa04110	0.25844110
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.24753356
76	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.23738794
77	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.22224971
78	Other glycan degradation_Homo sapiens_hsa00511	0.20843620
79	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.20655236
80	Renin-angiotensin system_Homo sapiens_hsa04614	0.20264569
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.19677254
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.19132661
83	Ribosome_Homo sapiens_hsa03010	0.18512462
84	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.17625583
85	Insulin resistance_Homo sapiens_hsa04931	0.16378520
86	Thyroid cancer_Homo sapiens_hsa05216	0.16068340
87	Alzheimers disease_Homo sapiens_hsa05010	0.15766283
88	Salivary secretion_Homo sapiens_hsa04970	0.15508242
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.15116700
90	Gap junction_Homo sapiens_hsa04540	0.14560463
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.14460499
92	MAPK signaling pathway_Homo sapiens_hsa04010	0.13985717
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.13949594
94	Huntingtons disease_Homo sapiens_hsa05016	0.13846941
95	Prolactin signaling pathway_Homo sapiens_hsa04917	0.12266981
96	Caffeine metabolism_Homo sapiens_hsa00232	0.12117092
97	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.10380467
98	Sulfur relay system_Homo sapiens_hsa04122	0.10060113
99	Renin secretion_Homo sapiens_hsa04924	0.09963646
100	Purine metabolism_Homo sapiens_hsa00230	0.09855930

MICA

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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