MICAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.56920186
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.21302689
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.21302689
4antigen processing and presentation of endogenous antigen (GO:0019883)5.18314845
5leukocyte aggregation (GO:0070486)4.65758934
6regulation of B cell receptor signaling pathway (GO:0050855)4.60989360
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.58034702
8positive thymic T cell selection (GO:0045059)4.48693352
9regulation of gamma-delta T cell differentiation (GO:0045586)4.48080776
10positive regulation by symbiont of host defense response (GO:0052509)4.38942631
11modulation by symbiont of host defense response (GO:0052031)4.38942631
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.38942631
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.38942631
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.38942631
15modulation by symbiont of host immune response (GO:0052553)4.38942631
16negative T cell selection (GO:0043383)4.36778018
17negative thymic T cell selection (GO:0045060)4.36612710
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.31762450
19negative regulation of cell killing (GO:0031342)4.31762450
20negative regulation of erythrocyte differentiation (GO:0045647)4.26475211
21response to peptidoglycan (GO:0032494)4.26090875
22detection of other organism (GO:0098543)4.23092884
23detection of bacterium (GO:0016045)4.22404362
24regulation of gamma-delta T cell activation (GO:0046643)4.16869392
25B cell receptor signaling pathway (GO:0050853)3.96107484
26mannose metabolic process (GO:0006013)3.93464639
27thymic T cell selection (GO:0045061)3.93148672
28macrophage activation involved in immune response (GO:0002281)3.90642163
29Arp2/3 complex-mediated actin nucleation (GO:0034314)3.80057718
30regulation of B cell differentiation (GO:0045577)3.75637338
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.68972543
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.63025501
33response to interleukin-15 (GO:0070672)3.61503536
34negative regulation of phagocytosis (GO:0050765)3.59325046
35positive T cell selection (GO:0043368)3.55970776
36regulation of dendritic cell antigen processing and presentation (GO:0002604)3.53944338
37interferon-gamma production (GO:0032609)3.52186521
38T cell selection (GO:0045058)3.49786456
39detection of external biotic stimulus (GO:0098581)3.45792425
40T cell migration (GO:0072678)3.43128908
41regulation of mast cell degranulation (GO:0043304)3.41528841
42regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.36963321
43defense response to protozoan (GO:0042832)3.34340675
44positive regulation of B cell differentiation (GO:0045579)3.29763332
45regulation of interleukin-12 biosynthetic process (GO:0045075)3.29490117
46regulation of myeloid leukocyte mediated immunity (GO:0002886)3.27911817
47cellular response to interleukin-15 (GO:0071350)3.27571890
48germinal center formation (GO:0002467)3.23521288
49regulation of leukocyte degranulation (GO:0043300)3.21884234
50leukocyte cell-cell adhesion (GO:0007159)3.17011118
51immunoglobulin mediated immune response (GO:0016064)3.16279570
52negative regulation of lymphocyte mediated immunity (GO:0002707)3.12395263
53regulation of antigen processing and presentation (GO:0002577)3.12359577
54positive regulation of antigen processing and presentation (GO:0002579)3.09759222
55regulation of mast cell activation involved in immune response (GO:0033006)3.09063253
56cellular extravasation (GO:0045123)3.08888823
57detection of biotic stimulus (GO:0009595)3.08278166
58antigen receptor-mediated signaling pathway (GO:0050851)3.07445914
59cellular response to zinc ion (GO:0071294)3.05238027
60positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05035166
61negative regulation of toll-like receptor signaling pathway (GO:0034122)3.04953542
62tolerance induction (GO:0002507)3.04328637
63response to type I interferon (GO:0034340)3.03704271
64response to protozoan (GO:0001562)3.02499719
65cellular response to type I interferon (GO:0071357)3.01659257
66type I interferon signaling pathway (GO:0060337)3.01659257
67myeloid cell activation involved in immune response (GO:0002275)2.98935335
68T cell costimulation (GO:0031295)2.98322247
69negative regulation of leukocyte mediated immunity (GO:0002704)2.97126315
70detection of molecule of bacterial origin (GO:0032490)2.94514031
71regulation of T cell receptor signaling pathway (GO:0050856)2.93520433
72NIK/NF-kappaB signaling (GO:0038061)2.91257700
73lymphocyte costimulation (GO:0031294)2.91173010
74positive regulation of lamellipodium assembly (GO:0010592)2.90333960
75regulation of T-helper 2 cell differentiation (GO:0045628)2.90229379
76respiratory burst (GO:0045730)2.90135785
77regulation of mast cell activation (GO:0033003)2.88649236
78neutrophil activation involved in immune response (GO:0002283)2.88621538
79actin nucleation (GO:0045010)2.88411469
80negative regulation of T cell mediated immunity (GO:0002710)2.87733603
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86223601
82response to host immune response (GO:0052572)2.85909817
83response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85909817
84antigen processing and presentation via MHC class Ib (GO:0002475)2.85855432
85T cell receptor signaling pathway (GO:0050852)2.85499723
86endothelial tube morphogenesis (GO:0061154)2.85303210
87morphogenesis of an endothelium (GO:0003159)2.85303210
88negative regulation of innate immune response (GO:0045824)2.84546660
89sequestering of actin monomers (GO:0042989)2.83595280
90regulation of alpha-beta T cell proliferation (GO:0046640)2.82509470
91regulation of T cell tolerance induction (GO:0002664)2.82168930
92positive regulation of mast cell activation (GO:0033005)2.81155158
93regulation of regulated secretory pathway (GO:1903305)2.80870664
94neutrophil activation (GO:0042119)2.80452594
95negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.80367240
96regulation of response to interferon-gamma (GO:0060330)2.76823614
97regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.76609287
98B cell mediated immunity (GO:0019724)2.72732061
99negative regulation of interleukin-12 production (GO:0032695)2.72597945
100positive regulation of interleukin-2 production (GO:0032743)2.72510491
101natural killer cell differentiation (GO:0001779)2.72316438
102response to host (GO:0075136)2.70395165
103response to host defenses (GO:0052200)2.70395165
104response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.70395165
105positive regulation of isotype switching (GO:0045830)2.69553152
106immune response-activating cell surface receptor signaling pathway (GO:0002429)2.69362691
107JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.69233989
108regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.67817263
109regulation of type I interferon-mediated signaling pathway (GO:0060338)2.66914734
110regulation of toll-like receptor signaling pathway (GO:0034121)2.62780228
111macrophage activation (GO:0042116)2.61988740
112negative regulation of interleukin-6 production (GO:0032715)2.61814330
113T cell homeostasis (GO:0043029)2.61613633
114negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61594323
115positive regulation of lamellipodium organization (GO:1902745)2.60756550
116lymphocyte homeostasis (GO:0002260)2.59993474
117positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59861620
118negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.59740257
119response to muramyl dipeptide (GO:0032495)2.59302649
120CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.58931293
121granulocyte activation (GO:0036230)2.58334466
122regulation of protein heterodimerization activity (GO:0043497)2.57080133
123positive regulation of mast cell degranulation (GO:0043306)2.56616945
124positive regulation of mast cell activation involved in immune response (GO:0033008)2.56616945
125ribosomal small subunit assembly (GO:0000028)2.56258072
126leukocyte degranulation (GO:0043299)2.54962075
127activated T cell proliferation (GO:0050798)2.54918008
128negative regulation of glycoprotein biosynthetic process (GO:0010561)2.53911939
129positive regulation of tolerance induction (GO:0002645)2.53856303
130regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.53757142
131negative regulation of T cell receptor signaling pathway (GO:0050860)2.53671483
132positive regulation of type 2 immune response (GO:0002830)2.52733000
133interferon-gamma-mediated signaling pathway (GO:0060333)2.51369953
134DNA unwinding involved in DNA replication (GO:0006268)2.50514090
135positive regulation of histone deacetylation (GO:0031065)2.50053542
136T cell proliferation (GO:0042098)2.49705994
137mast cell activation (GO:0045576)2.48302300
138positive regulation of alpha-beta T cell proliferation (GO:0046641)2.44412451
139mature B cell differentiation (GO:0002335)2.44319558
140regulation of interferon-beta biosynthetic process (GO:0045357)2.44099254
141natural killer cell activation (GO:0030101)2.44059096
142regulation of interleukin-2 biosynthetic process (GO:0045076)2.43310850
143T cell apoptotic process (GO:0070231)2.41363861
144B cell homeostasis (GO:0001782)2.41254268
145response to laminar fluid shear stress (GO:0034616)2.40816709
146pinocytosis (GO:0006907)2.40748630
147barbed-end actin filament capping (GO:0051016)2.39242767
148myeloid dendritic cell activation (GO:0001773)2.38922960
149negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.38138815
150angiogenesis involved in wound healing (GO:0060055)2.36806315
151negative regulation of stress fiber assembly (GO:0051497)2.34247320
152positive regulation of macrophage differentiation (GO:0045651)2.31641597
153regulation of tolerance induction (GO:0002643)2.30014231
154mononuclear cell proliferation (GO:0032943)2.29048745
155Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.28796224
156viral transcription (GO:0019083)2.28784321
157positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.27780453
158Fc-gamma receptor signaling pathway (GO:0038094)2.27681976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.76283974
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.89783702
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.75151570
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.67511431
5MYC_22102868_ChIP-Seq_BL_Human3.49751700
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.30408351
7* VDR_21846776_ChIP-Seq_THP-1_Human2.95625102
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92237969
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.85377563
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.76719624
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.74966253
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69404682
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.62000635
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.61380094
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58299127
16MAF_26560356_Chip-Seq_TH1_Human2.42404200
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38334621
18* MYB_26560356_Chip-Seq_TH2_Human2.34213416
19UTX_26944678_Chip-Seq_JUKART_Human2.24040154
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.19160976
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17597006
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17557426
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10783609
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09576373
25RUNX_20019798_ChIP-Seq_JUKART_Human2.07184355
26MYB_26560356_Chip-Seq_TH1_Human2.06677077
27* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03529792
28* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03284195
29* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02051628
30SPI1_23547873_ChIP-Seq_NB4_Human2.01670175
31TCF7_22412390_ChIP-Seq_EML_Mouse2.00632556
32* VDR_24763502_ChIP-Seq_THP-1_Human2.00110316
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99213475
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.97448490
35* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95823238
36* RUNX1_22412390_ChIP-Seq_EML_Mouse1.91339811
37* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89035698
38SCL_19346495_ChIP-Seq_HPC-7_Human1.86139762
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84017871
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82392008
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81048128
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.77794645
43KDM2B_26808549_Chip-Seq_DND41_Human1.72108992
44* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66891751
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66747003
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65599705
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65204304
48SPI1_23127762_ChIP-Seq_K562_Human1.60411827
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60212958
50MAF_26560356_Chip-Seq_TH2_Human1.60205870
51KDM2B_26808549_Chip-Seq_K562_Human1.54968649
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54561421
53* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54269380
54CIITA_25753668_ChIP-Seq_RAJI_Human1.53693203
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48776949
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48154852
57VDR_24787735_ChIP-Seq_THP-1_Human1.45459403
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45017217
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44183200
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40101238
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36571005
62DROSHA_22980978_ChIP-Seq_HELA_Human1.35047658
63BCOR_27268052_Chip-Seq_Bcells_Human1.34442633
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33702483
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.33234138
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31645659
67P68_20966046_ChIP-Seq_HELA_Human1.29072396
68GATA3_27048872_Chip-Seq_THYMUS_Human1.29003980
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27560847
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26600405
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25584258
72* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22784184
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22750241
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22143006
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21684922
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.19951577
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18386464
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17082747
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.16613520
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15062083
81GATA1_19941826_ChIP-Seq_K562_Human1.14263856
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13122502
83* PU_27001747_Chip-Seq_BMDM_Mouse1.13098801
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.12833993
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10350957
86SMC4_20622854_ChIP-Seq_HELA_Human1.10012895
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09789669
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08293073
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07677076
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07546261
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05927704
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05304790
93MYC_18555785_ChIP-Seq_MESCs_Mouse1.04649500
94* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04489300
95* LXR_22292898_ChIP-Seq_THP-1_Human1.03582232
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03210652
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02883972
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02855114
99NCOR1_26117541_ChIP-Seq_K562_Human1.02398548
100MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01595117
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01502344
102TFEB_21752829_ChIP-Seq_HELA_Human0.98939268
103* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96789618
104TET1_21451524_ChIP-Seq_MESCs_Mouse0.96644731
105E2F1_21310950_ChIP-Seq_MCF-7_Human0.95887571
106KDM2B_26808549_Chip-Seq_JURKAT_Human0.94417188
107CREB1_26743006_Chip-Seq_LNCaP_Human0.94350186
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94235744
109* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93215413
110GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93028897
111SA1_27219007_Chip-Seq_Bcells_Human0.93002796
112VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92982890
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92909614
114XRN2_22483619_ChIP-Seq_HELA_Human0.92042410
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91561679
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88844183
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85873790
118PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85195300
119FOXP3_21729870_ChIP-Seq_TREG_Human0.85173194
120VDR_23849224_ChIP-Seq_CD4+_Human0.84839121
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.83716552
122RACK7_27058665_Chip-Seq_MCF-7_Human0.80222117
123BCL6_27268052_Chip-Seq_Bcells_Human0.79294717
124GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77897007
125* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77821686
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77739850
127RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.77306228
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76563465
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.76392519
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75327969
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75243750
132* GATA3_26560356_Chip-Seq_TH2_Human0.74395234
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73960733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.41875728
2MP0000685_abnormal_immune_system3.03003761
3MP0003763_abnormal_thymus_physiology2.91706110
4MP0001800_abnormal_humoral_immune2.91691214
5MP0005671_abnormal_response_to2.77206368
6MP0005387_immune_system_phenotype2.69150444
7MP0001790_abnormal_immune_system2.69150444
8MP0003436_decreased_susceptibility_to2.65354314
9MP0003303_peritoneal_inflammation2.59038556
10MP0002452_abnormal_antigen_presenting2.58263572
11MP0005000_abnormal_immune_tolerance2.52202298
12MP0002396_abnormal_hematopoietic_system2.52007948
13MP0002420_abnormal_adaptive_immunity2.48314405
14MP0001819_abnormal_immune_cell2.44794099
15MP0002398_abnormal_bone_marrow2.37227560
16MP0002723_abnormal_immune_serum2.35591249
17MP0009785_altered_susceptibility_to2.24876754
18MP0003300_gastrointestinal_ulcer2.22108921
19MP0010352_gastrointestinal_tract_polyps2.20342542
20MP0002166_altered_tumor_susceptibility2.15554327
21MP0005025_abnormal_response_to2.15055334
22MP0002405_respiratory_system_inflammati2.12574926
23MP0009278_abnormal_bone_marrow2.11454623
24MP0002419_abnormal_innate_immunity2.11403110
25MP0000716_abnormal_immune_system2.10429343
26MP0008260_abnormal_autophagy2.01642757
27MP0009333_abnormal_splenocyte_physiolog1.97580001
28MP0000689_abnormal_spleen_morphology1.97536308
29MP0002722_abnormal_immune_system1.96982522
30MP0004808_abnormal_hematopoietic_stem1.91881094
31MP0002148_abnormal_hypersensitivity_rea1.82326829
32MP0002429_abnormal_blood_cell1.82213393
33MP0000703_abnormal_thymus_morphology1.81233602
34MP0002933_joint_inflammation1.80157276
35MP0010155_abnormal_intestine_physiology1.79742698
36MP0001873_stomach_inflammation1.79243890
37MP0002006_tumorigenesis1.76577905
38MP0005464_abnormal_platelet_physiology1.74648885
39MP0003191_abnormal_cellular_cholesterol1.74203775
40MP0001853_heart_inflammation1.66631108
41MP0000858_altered_metastatic_potential1.66002338
42MP0004947_skin_inflammation1.65473028
43MP0003566_abnormal_cell_adhesion1.64769151
44MP0003866_abnormal_defecation1.62269850
45MP0005397_hematopoietic_system_phenotyp1.61344939
46MP0001545_abnormal_hematopoietic_system1.61344939
47MP0009840_abnormal_foam_cell1.57456483
48MP0004510_myositis1.52466270
49MP0001845_abnormal_inflammatory_respons1.51731463
50MP0003693_abnormal_embryo_hatching1.49290487
51MP0003279_aneurysm1.48198185
52MP0006082_CNS_inflammation1.47129240
53MP0000490_abnormal_crypts_of1.47094447
54MP0003448_altered_tumor_morphology1.46877413
55MP0000465_gastrointestinal_hemorrhage1.45413962
56MP0005076_abnormal_cell_differentiation1.40963445
57MP0001533_abnormal_skeleton_physiology1.34905244
58MP0005023_abnormal_wound_healing1.34390259
59MP0004381_abnormal_hair_follicle1.32389541
60MP0003077_abnormal_cell_cycle1.31586221
61MP0003705_abnormal_hypodermis_morpholog1.31448381
62MP0005451_abnormal_body_composition1.30881525
63MP0010307_abnormal_tumor_latency1.28803084
64MP0005174_abnormal_tail_pigmentation1.25147817
65MP0006054_spinal_hemorrhage1.24439852
66MP0008438_abnormal_cutaneous_collagen1.24031483
67MP0002019_abnormal_tumor_incidence1.17407407
68MP0003724_increased_susceptibility_to1.15855564
69MP0010094_abnormal_chromosome_stability1.15392100
70MP0003111_abnormal_nucleus_morphology1.15253584
71MP0005409_darkened_coat_color1.14977144
72MP0003183_abnormal_peptide_metabolism1.10943773
73MP0001958_emphysema1.06332168
74MP0000604_amyloidosis1.05635525
75MP0009764_decreased_sensitivity_to1.04849879
76MP0008057_abnormal_DNA_replication1.04093034
77MP0003690_abnormal_glial_cell1.03699331
78MP0001348_abnormal_lacrimal_gland1.02895246
79MP0004957_abnormal_blastocyst_morpholog1.02492120
80MP0003091_abnormal_cell_migration1.00536682
81MP0000569_abnormal_digit_pigmentation1.00490166
82MP0002138_abnormal_hepatobiliary_system1.00334672
83MP0003075_altered_response_to0.99934539
84MP0003172_abnormal_lysosome_physiology0.99559598
85MP0004858_abnormal_nervous_system0.91280485
86MP0001849_ear_inflammation0.90466253
87MP0000350_abnormal_cell_proliferation0.89792839
88MP0005166_decreased_susceptibility_to0.88793566
89MP0002998_abnormal_bone_remodeling0.88285666
90MP0000343_altered_response_to0.87746854
91MP0003828_pulmonary_edema0.86766544
92MP0004883_abnormal_blood_vessel0.86012741
93MP0002254_reproductive_system_inflammat0.83901259
94MP0008469_abnormal_protein_level0.83353939
95MP0001986_abnormal_taste_sensitivity0.82515724
96MP0001730_embryonic_growth_arrest0.79227619
97MP0003045_fibrosis0.79063346
98MP0000767_abnormal_smooth_muscle0.78107616
99MP0005390_skeleton_phenotype0.76306522
100MP0008007_abnormal_cellular_replicative0.74771749
101MP0000733_abnormal_muscle_development0.74605187
102MP0000477_abnormal_intestine_morphology0.73954661
103MP0005058_abnormal_lysosome_morphology0.72494194
104MP0000313_abnormal_cell_death0.71185916
105MP0005310_abnormal_salivary_gland0.70085879
106MP0003453_abnormal_keratinocyte_physiol0.69186620
107MP0005381_digestive/alimentary_phenotyp0.68440002
108MP0001243_abnormal_dermal_layer0.66893281
109MP0003795_abnormal_bone_structure0.64381896
110MP0001851_eye_inflammation0.63698724
111MP0008004_abnormal_stomach_pH0.63321525
112MP0005621_abnormal_cell_physiology0.62928075
113MP0005075_abnormal_melanosome_morpholog0.62434943
114MP0000015_abnormal_ear_pigmentation0.60869571
115MP0000249_abnormal_blood_vessel0.60867767
116MP0002132_abnormal_respiratory_system0.60853622
117MP0002086_abnormal_extraembryonic_tissu0.60410443
118MP0005360_urolithiasis0.59578980
119MP0000371_diluted_coat_color0.58907326
120MP0008874_decreased_physiological_sensi0.58806596
121MP0002653_abnormal_ependyma_morphology0.57864346
122MP0001542_abnormal_bone_strength0.57536312
123MP0002925_abnormal_cardiovascular_devel0.56659628
124MP0001663_abnormal_digestive_system0.55567442

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.52712231
2Recurrent abscess formation (HP:0002722)4.20416713
3Recurrent fungal infections (HP:0002841)3.85698869
4IgM deficiency (HP:0002850)3.84120730
5Recurrent viral infections (HP:0004429)3.75504235
6Cellulitis (HP:0100658)3.70234149
7Recurrent bronchitis (HP:0002837)3.68961441
8T lymphocytopenia (HP:0005403)3.68487265
9Abnormality of T cell number (HP:0011839)3.55389784
10Elevated erythrocyte sedimentation rate (HP:0003565)3.54990658
11Recurrent bacterial skin infections (HP:0005406)3.47381220
12Myositis (HP:0100614)3.31148795
13Agammaglobulinemia (HP:0004432)3.17078695
14Thin bony cortex (HP:0002753)3.14241925
15Meningitis (HP:0001287)3.12569926
16Spontaneous hematomas (HP:0007420)3.10937772
17Autoimmune thrombocytopenia (HP:0001973)3.10732736
18Abnormality of T cells (HP:0002843)3.07792437
19Gastrointestinal infarctions (HP:0005244)3.01404468
20Increased cerebral lipofuscin (HP:0011813)3.01206699
21Chronic otitis media (HP:0000389)3.00435060
22Mediastinal lymphadenopathy (HP:0100721)2.97909696
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.94698774
24Dysostosis multiplex (HP:0000943)2.93754208
25Panhypogammaglobulinemia (HP:0003139)2.91822120
26Chronic obstructive pulmonary disease (HP:0006510)2.91441223
27Obstructive lung disease (HP:0006536)2.91441223
28Inflammation of the large intestine (HP:0002037)2.87861640
29Gastrointestinal inflammation (HP:0004386)2.87821606
30Abnormality of glycolipid metabolism (HP:0010969)2.86057145
31Abnormality of liposaccharide metabolism (HP:0010968)2.86057145
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.86057145
33Pustule (HP:0200039)2.85776622
34Lymphopenia (HP:0001888)2.85082232
35Abnormality of B cell number (HP:0010975)2.83419860
36B lymphocytopenia (HP:0010976)2.83419860
37Abnormality of cells of the lymphoid lineage (HP:0012140)2.82919591
38Recurrent cutaneous fungal infections (HP:0011370)2.75591103
39Chronic mucocutaneous candidiasis (HP:0002728)2.75591103
40Thrombocytosis (HP:0001894)2.74281631
41Combined immunodeficiency (HP:0005387)2.73414877
42Verrucae (HP:0200043)2.71449513
43Papilloma (HP:0012740)2.71449513
44Increased IgE level (HP:0003212)2.69412134
45Thyroiditis (HP:0100646)2.68797940
46Nasal polyposis (HP:0100582)2.68183074
47Severe combined immunodeficiency (HP:0004430)2.63640603
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.61115590
49Emphysema (HP:0002097)2.60357507
50Abnormality of the nasal mucosa (HP:0000433)2.60039765
51Gastrointestinal stroma tumor (HP:0100723)2.59912578
52Abnormality of the fingertips (HP:0001211)2.59249845
53Vasculitis (HP:0002633)2.57066407
54Eosinophilia (HP:0001880)2.56957119
55Recurrent skin infections (HP:0001581)2.54961368
56Abnormality of the peritoneum (HP:0002585)2.54767158
57Colitis (HP:0002583)2.53083846
58Stomatitis (HP:0010280)2.50141047
59Gingivitis (HP:0000230)2.50092130
60Systemic lupus erythematosus (HP:0002725)2.49866982
61Leukocytosis (HP:0001974)2.46909853
62Loss of speech (HP:0002371)2.44915260
63Cerebral aneurysm (HP:0004944)2.43740546
64Abnormality of macrophages (HP:0004311)2.42412642
65Abnormality of T cell physiology (HP:0011840)2.41219061
66Osteomyelitis (HP:0002754)2.37200129
67Increased density of long bones (HP:0006392)2.35987224
68Recurrent gram-negative bacterial infections (HP:0005420)2.34047196
69Abnormality of eosinophils (HP:0001879)2.33783668
70Abnormality of polysaccharide metabolism (HP:0011012)2.31082814
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31082814
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31082814
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28413904
74Aortic aneurysm (HP:0004942)2.28382910
75Mucopolysacchariduria (HP:0008155)2.27006423
76Urinary glycosaminoglycan excretion (HP:0003541)2.27006423
77Epistaxis (HP:0000421)2.26896863
78Abnormal platelet volume (HP:0011876)2.25883556
79IgA deficiency (HP:0002720)2.25864109
80Granulocytopenia (HP:0001913)2.25185081
81Ocular albinism (HP:0001107)2.24738117
82Peritonitis (HP:0002586)2.24046292
83Orchitis (HP:0100796)2.22144562
84Malnutrition (HP:0004395)2.21704996
85Chest pain (HP:0100749)2.20426996
86Hematochezia (HP:0002573)2.20345193
87Amyloidosis (HP:0011034)2.20079297
88IgG deficiency (HP:0004315)2.18513870
89Interstitial pulmonary disease (HP:0006530)2.18033966
90Obstructive sleep apnea (HP:0002870)2.16414878
91Lymphoma (HP:0002665)2.13575015
92Gingival bleeding (HP:0000225)2.13183189
93Skin ulcer (HP:0200042)2.12623210
94Restrictive lung disease (HP:0002091)2.12268125
95Sepsis (HP:0100806)2.11834281
96Periodontitis (HP:0000704)2.09741334
97Premature loss of primary teeth (HP:0006323)2.06300073
98Hemoptysis (HP:0002105)2.05148039
99Petechiae (HP:0000967)2.02928475
100Basal cell carcinoma (HP:0002671)2.02733160
101Recurrent sinusitis (HP:0011108)2.02417299
102Purpura (HP:0000979)2.01834666
103Bicuspid aortic valve (HP:0001647)2.01334996
104Spondylolisthesis (HP:0003302)1.99650439
105Aortic dissection (HP:0002647)1.99597702
106Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99512271
107Short 4th metacarpal (HP:0010044)1.99512271
108Recurrent lower respiratory tract infections (HP:0002783)1.98773147
109Thoracic kyphosis (HP:0002942)1.96346594
110Keratoconjunctivitis sicca (HP:0001097)1.96152543
111Pulmonary infiltrates (HP:0002113)1.94415429
112Arterial thrombosis (HP:0004420)1.93942669
113Protrusio acetabuli (HP:0003179)1.93895222
114Chronic diarrhea (HP:0002028)1.92361158
115Metaphyseal cupping (HP:0003021)1.92018142
116Optic neuritis (HP:0100653)1.91001503
117Retrobulbar optic neuritis (HP:0100654)1.91001503
118Broad face (HP:0000283)1.90781303
119Recurrent pneumonia (HP:0006532)1.90738193
120Dilatation of the ascending aorta (HP:0005111)1.90482695
121Encephalitis (HP:0002383)1.87739116
122Polygenic inheritance (HP:0010982)1.85971141
123Increased mean platelet volume (HP:0011877)1.85787485
124Prolonged bleeding time (HP:0003010)1.83321224
125Episodic fever (HP:0001954)1.82729511
126Chronic sinusitis (HP:0011109)1.81470920
127Keratoconjunctivitis (HP:0001096)1.80856467
128Bronchitis (HP:0012387)1.80463375
129Hypochromic anemia (HP:0001931)1.79437905
130Iris hypopigmentation (HP:0007730)1.79436268
131Ankle contracture (HP:0006466)1.79424611
132Vacuolated lymphocytes (HP:0001922)1.75226844
133Ulnar bowing (HP:0003031)1.75145307
134Persistence of primary teeth (HP:0006335)1.74543470
135Hyperacusis (HP:0010780)1.72744216
136Hypergammaglobulinemia (HP:0010702)1.72475304
137Urticaria (HP:0001025)1.71758002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.10556719
2MAP3K103.13553509
3PRPF4B2.83721463
4EEF2K2.76675007
5STK102.72975505
6GRK62.41403090
7TRIB32.40945750
8PKN22.27567526
9BLK2.23423129
10JAK32.21112549
11TXK2.17426328
12ZAP702.15975021
13ITK2.09017483
14ERN12.06954498
15LRRK21.98398440
16TYK21.93279880
17BTK1.89910944
18KIT1.65992302
19TTN1.63874918
20CSK1.62940091
21IRAK41.57537789
22CDK121.56687077
23CSF1R1.55198525
24CDC42BPA1.53395829
25TEC1.52538890
26TBK11.52262135
27JAK11.51265395
28MARK21.50471666
29SYK1.43258316
30FGFR41.41085353
31PRKD21.40147419
32HCK1.36557488
33TESK21.34831618
34MAP3K141.27583854
35LCK1.27484472
36EPHB11.26586875
37FGFR31.25978978
38SIK21.22526012
39RPS6KA41.21942800
40IKBKE1.19806515
41CLK11.19707532
42RIPK41.18776431
43MAP2K31.16876784
44PIM11.16198281
45NEK21.13860849
46MAP3K61.13791640
47MARK31.12893139
48TGFBR21.11008150
49KSR21.04056629
50PTK61.01372844
51MAP3K30.99715493
52MAPK70.98456120
53KDR0.96107320
54IKBKB0.95569385
55FLT30.95288137
56MAP3K10.94230387
57TRPM70.92613827
58CDK40.91223347
59MST40.89370229
60SMG10.88650899
61CDC70.87810114
62LYN0.87246717
63MAPK120.86830211
64MAP3K80.86801424
65RPS6KA20.86518600
66NLK0.85007769
67PAK40.84607987
68CAMKK10.82682371
69FES0.82664615
70MAP3K130.80523805
71PDPK10.80322221
72ICK0.79770374
73RPS6KB20.77131613
74IRAK30.76643705
75STK40.74144968
76CHUK0.70367413
77TYRO30.68537524
78DYRK1B0.67777739
79HIPK20.66936107
80NME20.66578214
81SGK30.66356651
82TESK10.65196937
83CDK60.65195007
84ALK0.65088240
85EPHA30.63733554
86DDR20.63014581
87DAPK20.61910079
88TGFBR10.61626252
89MATK0.60906707
90MOS0.60708093
91MAP3K110.59031526
92JAK20.58530711
93MAP2K60.57934094
94PRKCH0.56921825
95PRKCQ0.56075787
96PDGFRB0.54311181
97RPS6KA60.54001644
98TAOK20.53911525
99SCYL20.53503866
100DMPK0.53421599
101MAPKAPK20.52986449
102NEK90.52782547
103RET0.50862170
104IRAK10.50682922
105MAP3K70.48867034
106SGK20.48646937
107ILK0.48363327
108RPS6KL10.47508540
109RPS6KC10.47508540
110PDGFRA0.46280874
111CDK190.46036051
112RIPK10.44544889
113CDK70.44532724
114MAPKAPK30.43431897
115TAOK10.42996906
116IRAK20.42991060
117YES10.42573472
118MAPK110.41746773
119FGR0.40585199
120SIK30.40305518
121PTK2B0.39334335
122PRKG20.38664599
123STK110.38568611
124MELK0.38192819
125ARAF0.38181399
126SIK10.37783572
127ATR0.36796335
128BMX0.36395522
129STK240.36226689
130TNK20.35337514
131PIM20.34460779
132PDK10.32638983
133FYN0.32279264

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.53247457
2B cell receptor signaling pathway_Homo sapiens_hsa046622.49261487
3Leishmaniasis_Homo sapiens_hsa051402.39081905
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.11500191
5Autoimmune thyroid disease_Homo sapiens_hsa053202.08150355
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.00833652
7Osteoclast differentiation_Homo sapiens_hsa043802.00487190
8T cell receptor signaling pathway_Homo sapiens_hsa046601.98436986
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88164608
10Measles_Homo sapiens_hsa051621.87655202
11Antigen processing and presentation_Homo sapiens_hsa046121.87487234
12Hematopoietic cell lineage_Homo sapiens_hsa046401.87148143
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83937035
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.81493736
15DNA replication_Homo sapiens_hsa030301.80341939
16Viral myocarditis_Homo sapiens_hsa054161.74585616
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.70417882
18Shigellosis_Homo sapiens_hsa051311.61077658
19Type I diabetes mellitus_Homo sapiens_hsa049401.59382205
20Base excision repair_Homo sapiens_hsa034101.56358295
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49665268
22Chronic myeloid leukemia_Homo sapiens_hsa052201.46321298
23Toxoplasmosis_Homo sapiens_hsa051451.44708869
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44229918
25Apoptosis_Homo sapiens_hsa042101.39233716
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.36529156
27Acute myeloid leukemia_Homo sapiens_hsa052211.36181814
28Mismatch repair_Homo sapiens_hsa034301.35852570
29Herpes simplex infection_Homo sapiens_hsa051681.35841281
30Hepatitis B_Homo sapiens_hsa051611.27308326
31Graft-versus-host disease_Homo sapiens_hsa053321.26813900
32Tuberculosis_Homo sapiens_hsa051521.23264465
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23255754
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22987891
35Pancreatic cancer_Homo sapiens_hsa052121.22816619
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21510819
37Chemokine signaling pathway_Homo sapiens_hsa040621.20272848
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20089383
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16668758
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15102168
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14637696
42Phagosome_Homo sapiens_hsa041451.13220474
43Legionellosis_Homo sapiens_hsa051341.12773512
44Platelet activation_Homo sapiens_hsa046111.12627361
45Salmonella infection_Homo sapiens_hsa051321.12451924
46Influenza A_Homo sapiens_hsa051641.12407550
47HTLV-I infection_Homo sapiens_hsa051661.11712855
48Epstein-Barr virus infection_Homo sapiens_hsa051691.09793535
49p53 signaling pathway_Homo sapiens_hsa041151.07668602
50Viral carcinogenesis_Homo sapiens_hsa052031.06602046
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.05929580
52TNF signaling pathway_Homo sapiens_hsa046681.05469457
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.01897073
54Ribosome_Homo sapiens_hsa030101.00642141
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99991375
56Small cell lung cancer_Homo sapiens_hsa052220.99465286
57Malaria_Homo sapiens_hsa051440.98244872
58Non-small cell lung cancer_Homo sapiens_hsa052230.96283959
59Rheumatoid arthritis_Homo sapiens_hsa053230.96181201
60Notch signaling pathway_Homo sapiens_hsa043300.95541117
61Colorectal cancer_Homo sapiens_hsa052100.94971973
62Spliceosome_Homo sapiens_hsa030400.94480563
63VEGF signaling pathway_Homo sapiens_hsa043700.93096030
64Cell cycle_Homo sapiens_hsa041100.92932006
65Pertussis_Homo sapiens_hsa051330.92725176
66Allograft rejection_Homo sapiens_hsa053300.92552887
67GnRH signaling pathway_Homo sapiens_hsa049120.88544014
68MicroRNAs in cancer_Homo sapiens_hsa052060.87485103
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86844476
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86326192
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84761478
72Choline metabolism in cancer_Homo sapiens_hsa052310.80626971
73Proteoglycans in cancer_Homo sapiens_hsa052050.79705187
74African trypanosomiasis_Homo sapiens_hsa051430.79459819
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78195199
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77909306
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76021863
78Focal adhesion_Homo sapiens_hsa045100.74177324
79Other glycan degradation_Homo sapiens_hsa005110.72339154
80Adherens junction_Homo sapiens_hsa045200.72038323
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71364126
82HIF-1 signaling pathway_Homo sapiens_hsa040660.70650177
83Dorso-ventral axis formation_Homo sapiens_hsa043200.68912881
84Renin-angiotensin system_Homo sapiens_hsa046140.67659261
85mTOR signaling pathway_Homo sapiens_hsa041500.67654365
86Non-homologous end-joining_Homo sapiens_hsa034500.66585168
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66276299
88Homologous recombination_Homo sapiens_hsa034400.66021333
89Renal cell carcinoma_Homo sapiens_hsa052110.65710633
90Thyroid cancer_Homo sapiens_hsa052160.65075074
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.64816489
92Hepatitis C_Homo sapiens_hsa051600.64019500
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.63685252
94MAPK signaling pathway_Homo sapiens_hsa040100.61038588
95Endocytosis_Homo sapiens_hsa041440.59431722
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59311878
97Inositol phosphate metabolism_Homo sapiens_hsa005620.58707953
98Pathways in cancer_Homo sapiens_hsa052000.58008840
99Prolactin signaling pathway_Homo sapiens_hsa049170.57482426
100RNA transport_Homo sapiens_hsa030130.57278423
101Nucleotide excision repair_Homo sapiens_hsa034200.55225082
102Estrogen signaling pathway_Homo sapiens_hsa049150.54449541
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.52882852
104FoxO signaling pathway_Homo sapiens_hsa040680.51351795
105Endometrial cancer_Homo sapiens_hsa052130.50988525
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.50771530
107Bladder cancer_Homo sapiens_hsa052190.50581401
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50381419
109Lysosome_Homo sapiens_hsa041420.49993441
110Amoebiasis_Homo sapiens_hsa051460.49786985
111mRNA surveillance pathway_Homo sapiens_hsa030150.48499575
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.47858508
113ErbB signaling pathway_Homo sapiens_hsa040120.47830185
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47565265
115Asthma_Homo sapiens_hsa053100.46820608
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46158628
117Prostate cancer_Homo sapiens_hsa052150.45830652
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45631444
119Staphylococcus aureus infection_Homo sapiens_hsa051500.45039770
120Insulin resistance_Homo sapiens_hsa049310.44229468
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43820779
122Type II diabetes mellitus_Homo sapiens_hsa049300.43809811
123Rap1 signaling pathway_Homo sapiens_hsa040150.43801316
124Prion diseases_Homo sapiens_hsa050200.43243357
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39178064
126Glioma_Homo sapiens_hsa052140.38716186

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »