MICAL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.10105403
2locomotory exploration behavior (GO:0035641)4.91632643
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.91524459
4synaptic vesicle maturation (GO:0016188)4.89492450
5glutamate secretion (GO:0014047)4.70921579
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.58155384
7cell adhesion mediated by integrin (GO:0033627)4.58043119
8vocalization behavior (GO:0071625)4.51932281
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.46729022
10cell communication by electrical coupling (GO:0010644)4.26952436
11skin morphogenesis (GO:0043589)4.26463334
12protein localization to endosome (GO:0036010)4.22055059
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.09357363
14synaptic vesicle exocytosis (GO:0016079)4.08642057
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.99105559
16regulation of glutamate receptor signaling pathway (GO:1900449)3.95795061
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.87476383
18endodermal cell differentiation (GO:0035987)3.86736058
19regulation of synaptic vesicle exocytosis (GO:2000300)3.81402799
20ionotropic glutamate receptor signaling pathway (GO:0035235)3.81222501
21sodium ion export (GO:0071436)3.70132906
22cell-substrate junction assembly (GO:0007044)3.62856312
23hypotonic response (GO:0006971)3.61584275
24regulation of neuronal synaptic plasticity (GO:0048168)3.60119923
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.54357388
26neuronal action potential propagation (GO:0019227)3.54336749
27hemidesmosome assembly (GO:0031581)3.53204663
28cellular potassium ion homeostasis (GO:0030007)3.50337685
29plasma membrane repair (GO:0001778)3.49202735
30regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.48256096
31regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.47609181
32positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.47104732
33mesodermal cell differentiation (GO:0048333)3.46937326
34glutamate receptor signaling pathway (GO:0007215)3.46068034
35exploration behavior (GO:0035640)3.45217343
36synaptic transmission, glutamatergic (GO:0035249)3.43717421
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.42604363
38regulation of synaptic vesicle transport (GO:1902803)3.41857703
39protein localization to synapse (GO:0035418)3.40522365
40substrate-dependent cell migration (GO:0006929)3.40001356
41cell communication involved in cardiac conduction (GO:0086065)3.32798173
42regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.31791166
43positive regulation of receptor recycling (GO:0001921)3.31709347
44regulation of synapse structural plasticity (GO:0051823)3.30287742
45collagen fibril organization (GO:0030199)3.27825712
46neurotransmitter-gated ion channel clustering (GO:0072578)3.24892994
47positive regulation of synapse maturation (GO:0090129)3.24606809
48stress fiber assembly (GO:0043149)3.23959810
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.22650879
50neurotransmitter secretion (GO:0007269)3.21954780
51regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.21549716
52long-term memory (GO:0007616)3.21203130
53activation of protein kinase A activity (GO:0034199)3.19648059
54cardiac myofibril assembly (GO:0055003)3.17190133
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.12852319
56positive regulation of blood vessel endothelial cell migration (GO:0043536)3.11916553
57positive regulation of fibroblast migration (GO:0010763)3.11609321
58dendritic spine morphogenesis (GO:0060997)3.09420961
59positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.06687157
60regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.06125610
61regulation of dendritic spine morphogenesis (GO:0061001)3.05341546
62cortical actin cytoskeleton organization (GO:0030866)3.01943863
63regulation of synaptic plasticity (GO:0048167)2.97958940
64membrane raft organization (GO:0031579)2.96674050
65extracellular fibril organization (GO:0043206)2.94854116
66proline transport (GO:0015824)2.94638344
67wound healing, spreading of epidermal cells (GO:0035313)2.94606852
68regulation of postsynaptic membrane potential (GO:0060078)2.93754662
69regulation of transforming growth factor beta1 production (GO:0032908)2.92792748
70neuron-neuron synaptic transmission (GO:0007270)2.92722851
71layer formation in cerebral cortex (GO:0021819)2.92550527
72establishment of nucleus localization (GO:0040023)2.92333079
73barbed-end actin filament capping (GO:0051016)2.91782532
74membrane depolarization during action potential (GO:0086010)2.91768646
75negative regulation of fatty acid transport (GO:2000192)2.90722350
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88249293
77protein targeting to plasma membrane (GO:0072661)2.87877409
78detection of calcium ion (GO:0005513)2.87832437
79cellular sodium ion homeostasis (GO:0006883)2.84675697
80COPI coating of Golgi vesicle (GO:0048205)2.84037609
81Golgi transport vesicle coating (GO:0048200)2.84037609
82regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.83820114
83cell-substrate adherens junction assembly (GO:0007045)2.82498660
84focal adhesion assembly (GO:0048041)2.82498660
85cytoskeletal anchoring at plasma membrane (GO:0007016)2.80618564
86membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.80581075
87positive regulation of membrane potential (GO:0045838)2.80093175
88regulation of membrane repolarization (GO:0060306)2.79403809
89sequestering of extracellular ligand from receptor (GO:0035581)2.78790240
90fibril organization (GO:0097435)2.78446573
91dendrite morphogenesis (GO:0048813)2.77284556
92adherens junction assembly (GO:0034333)2.76893022
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75612425
94chemosensory behavior (GO:0007635)2.74815553
95potassium ion import (GO:0010107)2.74069675
96cerebellar Purkinje cell differentiation (GO:0021702)2.73751073
97chondrocyte proliferation (GO:0035988)2.73331724
98dendritic spine organization (GO:0097061)2.72997474
99long-term synaptic potentiation (GO:0060291)2.72746618
100hemoglobin metabolic process (GO:0020027)2.72449073
101innervation (GO:0060384)2.71721240
102vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.71367295
103cerebellar granule cell differentiation (GO:0021707)2.70918552
104extracellular matrix assembly (GO:0085029)2.70782765
105synaptic vesicle endocytosis (GO:0048488)2.69126840
106venous blood vessel morphogenesis (GO:0048845)2.68848971
107regulation of early endosome to late endosome transport (GO:2000641)2.68800263
108neuromuscular process controlling balance (GO:0050885)2.68407022
109cardiac conduction (GO:0061337)2.67665775
110gamma-aminobutyric acid transport (GO:0015812)2.66928221
111regulation of calcium ion transmembrane transport (GO:1903169)2.66825623
112regulation of calcium ion transmembrane transporter activity (GO:1901019)2.66825623
113positive regulation of potassium ion transmembrane transport (GO:1901381)2.66304791
114positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.65734523
115regulation of neurotransmitter secretion (GO:0046928)2.65619945
116endocardial cushion development (GO:0003197)2.65578517
117cardiac muscle contraction (GO:0060048)2.65564351
118protein heterotrimerization (GO:0070208)2.65480604
119collagen metabolic process (GO:0032963)2.63968505
120negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.63818163
121cortical cytoskeleton organization (GO:0030865)2.63448673
122regulation of cell communication by electrical coupling (GO:0010649)2.62565791
123axonal fasciculation (GO:0007413)2.62078396
124maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61349789
125protein retention in ER lumen (GO:0006621)2.60734854
126membrane depolarization (GO:0051899)2.60529515
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60355857
128G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.58801131
129negative regulation of anoikis (GO:2000811)2.57665681
130regulation of dendritic spine development (GO:0060998)2.57047408
131myofibril assembly (GO:0030239)2.56731319
132regulation of synapse maturation (GO:0090128)2.56620320
133regulation of ARF protein signal transduction (GO:0032012)2.56503723
134neuron cell-cell adhesion (GO:0007158)2.55757226
135membrane repolarization (GO:0086009)2.55436962
136regulation of voltage-gated calcium channel activity (GO:1901385)2.55297499
137relaxation of cardiac muscle (GO:0055119)2.54468776
138basement membrane organization (GO:0071711)2.54368879
139pericardium development (GO:0060039)2.53486448
140regulation of ion transmembrane transporter activity (GO:0032412)2.52700051
141sarcomere organization (GO:0045214)2.52416246
142ventricular cardiac muscle cell action potential (GO:0086005)2.52330164
143long term synaptic depression (GO:0060292)2.51892578
144neuron recognition (GO:0008038)2.51574927
145membrane repolarization during action potential (GO:0086011)2.51245381
146regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.50506705
147positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.50444488
148regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.49372018
149collagen catabolic process (GO:0030574)2.46206316
150wound healing, spreading of cells (GO:0044319)2.45625397
151positive regulation of osteoblast proliferation (GO:0033690)2.45538049
152multicellular organismal macromolecule metabolic process (GO:0044259)2.42839185
153actin filament bundle organization (GO:0061572)2.42340283
154actin filament bundle assembly (GO:0051017)2.42340283
155positive regulation of axon extension (GO:0045773)2.41148178
156cell migration involved in heart development (GO:0060973)2.39376654
157extracellular matrix disassembly (GO:0022617)2.38526527
158import into cell (GO:0098657)2.38223893
159peptidyl-proline hydroxylation (GO:0019511)2.35996504
160sprouting angiogenesis (GO:0002040)2.35525323
161cellular response to vitamin (GO:0071295)2.33867555
162negative regulation of protein localization to plasma membrane (GO:1903077)2.33260625
163apoptotic cell clearance (GO:0043277)2.31116953
164epithelial cell-cell adhesion (GO:0090136)2.30595481
165endocytic recycling (GO:0032456)2.29521136
166negative regulation of focal adhesion assembly (GO:0051895)2.28666890
167negative regulation of cell junction assembly (GO:1901889)2.28666890
168negative regulation of adherens junction organization (GO:1903392)2.28666890
169multicellular organismal metabolic process (GO:0044236)2.28633211
170platelet aggregation (GO:0070527)2.27319532
171heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.26582176
172multicellular organismal catabolic process (GO:0044243)2.25559135
173regulation of macrophage cytokine production (GO:0010935)2.25223222
174regulation of anoikis (GO:2000209)2.24875957
175protein hydroxylation (GO:0018126)2.24715148
176retina vasculature morphogenesis in camera-type eye (GO:0061299)2.24685364
177regulation of transforming growth factor beta2 production (GO:0032909)2.24245842
178integrin-mediated signaling pathway (GO:0007229)2.22913807
179endothelial cell morphogenesis (GO:0001886)2.21439669
180peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.21255783
181substrate adhesion-dependent cell spreading (GO:0034446)2.20465629
182positive regulation of epithelial cell migration (GO:0010634)2.19774629
183regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.19584457
184chondroitin sulfate biosynthetic process (GO:0030206)2.17798991
185vascular endothelial growth factor signaling pathway (GO:0038084)2.17180683
186vesicle coating (GO:0006901)2.16632937
187pathway-restricted SMAD protein phosphorylation (GO:0060389)2.16210514
188regulation of fibroblast migration (GO:0010762)2.14247116
189atrioventricular valve morphogenesis (GO:0003181)2.13967612
190response to gravity (GO:0009629)2.13877480

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.00804086
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.12599777
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06551402
4GBX2_23144817_ChIP-Seq_PC3_Human2.90105149
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85879885
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75847791
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59490701
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59490701
9DROSHA_22980978_ChIP-Seq_HELA_Human2.59165172
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57206398
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42464009
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34720976
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33334874
14* GATA2_21666600_ChIP-Seq_HMVEC_Human2.32749238
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32663090
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31791005
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.23627053
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.20833238
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20014856
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.16885555
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.12953192
22* ELK3_25401928_ChIP-Seq_HUVEC_Human2.07616054
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.02154946
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.00353949
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.96098400
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.88664821
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84397237
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81571408
29REST_21632747_ChIP-Seq_MESCs_Mouse1.80070787
30* EP300_21415370_ChIP-Seq_HL-1_Mouse1.74666504
31* GATA1_19941826_ChIP-Seq_K562_Human1.74520543
32CLOCK_20551151_ChIP-Seq_293T_Human1.73544021
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70882124
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70882124
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70774731
36* BRD4_25478319_ChIP-Seq_HGPS_Human1.70218523
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.69704631
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68140383
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.64495718
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61999213
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58494012
42* CJUN_26792858_Chip-Seq_BT549_Human1.58161372
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.57334557
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56163863
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55751659
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54988566
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52139636
48JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48971702
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48819632
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48669253
51* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48210193
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47859095
53* SMAD4_21799915_ChIP-Seq_A2780_Human1.47477028
54AR_21572438_ChIP-Seq_LNCaP_Human1.46105266
55* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46010018
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45283434
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45114246
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44392006
59TP53_16413492_ChIP-PET_HCT116_Human1.44105947
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44049163
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.42917738
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42051548
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41118324
64* SMAD_19615063_ChIP-ChIP_OVARY_Human1.40430905
65LXR_22292898_ChIP-Seq_THP-1_Human1.39314515
66* TBX20_22080862_ChIP-Seq_HEART_Mouse1.37840390
67* TBX20_22328084_ChIP-Seq_HEART_Mouse1.37840390
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37705533
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36969836
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36508691
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.35987862
72TP53_22127205_ChIP-Seq_IMR90_Human1.34811286
73* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32041444
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31627416
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31200005
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30136099
77KDM2B_26808549_Chip-Seq_DND41_Human1.29794134
78TCF7_22412390_ChIP-Seq_EML_Mouse1.28641870
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28445880
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27348549
81RACK7_27058665_Chip-Seq_MCF-7_Human1.25619639
82* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24976567
83* UBF1/2_26484160_Chip-Seq_HMECs_Human1.24095419
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24017688
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23985659
86* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23059952
87AHR_22903824_ChIP-Seq_MCF-7_Human1.22918672
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22821842
89ZNF274_21170338_ChIP-Seq_K562_Hela1.22632140
90* AR_19668381_ChIP-Seq_PC3_Human1.22155552
91SMC1_22415368_ChIP-Seq_MEFs_Mouse1.22029834
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21764000
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21348112
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21073787
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.21072745
96* GATA2_19941826_ChIP-Seq_K562_Human1.20635857
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.20449199
98* TP53_23651856_ChIP-Seq_MEFs_Mouse1.20432022
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.20423124
100RING1B_27294783_Chip-Seq_ESCs_Mouse1.20303429
101KDM2B_26808549_Chip-Seq_JURKAT_Human1.17686689
102KDM2B_26808549_Chip-Seq_K562_Human1.17363712
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16846024
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.16284581
105* TP53_18474530_ChIP-ChIP_U2OS_Human1.15950695
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.15594769
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15574307
108* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15391363
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14957267
110HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14708987
111ESR1_20079471_ChIP-ChIP_T-47D_Human1.13931300
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11879813
113AR_25329375_ChIP-Seq_VCAP_Human1.10423086
114* SMAD3_21741376_ChIP-Seq_HESCs_Human1.10175474
115ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09214020
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09069663
117NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09069663
118STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08259165
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07869146
120CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07813720
121SPI1_23127762_ChIP-Seq_K562_Human1.07581821
122NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07562757
123EGR1_19374776_ChIP-ChIP_THP-1_Human1.07320683
124SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07241457
125ATF3_27146783_Chip-Seq_COLON_Human1.06813429
126* STAT3_23295773_ChIP-Seq_U87_Human1.06336811
127* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05162834
128* SMAD3_21741376_ChIP-Seq_EPCs_Human1.04870214
129SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04832574
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04421510
131TET1_21490601_ChIP-Seq_MESCs_Mouse1.03922242
132* SMAD4_21741376_ChIP-Seq_HESCs_Human1.03801477
133CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03745524
134DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03692434
135EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03580420
136CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03300885
137ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02048463
138ESR2_21235772_ChIP-Seq_MCF-7_Human1.01653118
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99072303
140* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98815728
141P300_19829295_ChIP-Seq_ESCs_Human0.98642277
142* RXR_22108803_ChIP-Seq_LS180_Human0.98087973
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97619537
144RING1B_27294783_Chip-Seq_NPCs_Mouse0.97530465
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97501566
146TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97402009
147ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96753172
148BCAT_22108803_ChIP-Seq_LS180_Human0.96711645
149STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96623660
150CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95771610
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95303087
152P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94979319
153RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94747601
154PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94438006
155* TCF4_23295773_ChIP-Seq_U87_Human0.94397390
156TP53_20018659_ChIP-ChIP_R1E_Mouse0.91676443
157VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91647081
158* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89873361
159TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89626625
160ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89134597
161SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88990209
162DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88331746
163TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87549219
164TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86495882
165RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86112229
166ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83963344
167KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83749818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.68607317
2MP0003635_abnormal_synaptic_transmissio3.45499185
3MP0004270_analgesia3.07606001
4MP0003880_abnormal_central_pattern3.05987334
5MP0000751_myopathy2.77212257
6MP0005257_abnormal_intraocular_pressure2.75858029
7MP0002063_abnormal_learning/memory/cond2.64407714
8MP0009780_abnormal_chondrocyte_physiolo2.59683960
9MP0009745_abnormal_behavioral_response2.58057668
10MP0002837_dystrophic_cardiac_calcinosis2.39106386
11MP0003950_abnormal_plasma_membrane2.35809149
12MP0009046_muscle_twitch2.33857076
13MP0002064_seizures2.33709203
14MP0005023_abnormal_wound_healing2.25364361
15MP0003191_abnormal_cellular_cholesterol2.25078640
16MP0004084_abnormal_cardiac_muscle2.24592502
17MP0004215_abnormal_myocardial_fiber2.10001016
18MP0002572_abnormal_emotion/affect_behav2.08956232
19MP0005623_abnormal_meninges_morphology2.07245506
20MP0001968_abnormal_touch/_nociception2.00245247
21MP0010352_gastrointestinal_tract_polyps1.94016939
22MP0008438_abnormal_cutaneous_collagen1.92336663
23MP0002877_abnormal_melanocyte_morpholog1.89433729
24MP0000767_abnormal_smooth_muscle1.89360331
25MP0004858_abnormal_nervous_system1.85964160
26MP0004145_abnormal_muscle_electrophysio1.84812550
27MP0002272_abnormal_nervous_system1.79441285
28MP0002734_abnormal_mechanical_nocicepti1.78735427
29MP0001348_abnormal_lacrimal_gland1.78477966
30MP0003300_gastrointestinal_ulcer1.77220091
31MP0000749_muscle_degeneration1.77029193
32MP0001486_abnormal_startle_reflex1.74137053
33MP0008569_lethality_at_weaning1.71592237
34MP0004036_abnormal_muscle_relaxation1.71264673
35MP0001501_abnormal_sleep_pattern1.70189076
36MP0002060_abnormal_skin_morphology1.62946815
37MP0002736_abnormal_nociception_after1.62666926
38MP0003828_pulmonary_edema1.60131047
39MP0001440_abnormal_grooming_behavior1.57115673
40MP0005409_darkened_coat_color1.56474089
41MP0002735_abnormal_chemical_nociception1.54715042
42MP0004484_altered_response_of1.52189985
43MP0005620_abnormal_muscle_contractility1.51765126
44MP0004510_myositis1.51503442
45MP0002972_abnormal_cardiac_muscle1.48501307
46MP0004085_abnormal_heartbeat1.47788957
47MP0003137_abnormal_impulse_conducting1.47477087
48MP0003329_amyloid_beta_deposits1.46138737
49MP0001542_abnormal_bone_strength1.45882262
50MP0000013_abnormal_adipose_tissue1.43464487
51MP0005275_abnormal_skin_tensile1.42576339
52MP0005451_abnormal_body_composition1.38327472
53MP0003279_aneurysm1.37770411
54MP0002909_abnormal_adrenal_gland1.37160167
55MP0004087_abnormal_muscle_fiber1.36621086
56MP0005330_cardiomyopathy1.35616890
57MP0003879_abnormal_hair_cell1.35442657
58MP0008260_abnormal_autophagy1.33884674
59MP0004233_abnormal_muscle_weight1.32331170
60MP0005164_abnormal_response_to1.32223018
61MP0005503_abnormal_tendon_morphology1.31025317
62MP0004811_abnormal_neuron_physiology1.30274590
63MP0002067_abnormal_sensory_capabilities1.30206424
64MP0006054_spinal_hemorrhage1.28319277
65MP0003656_abnormal_erythrocyte_physiolo1.27591568
66MP0006138_congestive_heart_failure1.26843610
67MP0001849_ear_inflammation1.26006936
68MP0002896_abnormal_bone_mineralization1.25311723
69MP0003705_abnormal_hypodermis_morpholog1.22049236
70MP0008775_abnormal_heart_ventricle1.21116816
71MP0002822_catalepsy1.20844376
72MP0003283_abnormal_digestive_organ1.19741986
73MP0002184_abnormal_innervation1.18596891
74MP0001958_emphysema1.17889201
75MP0003436_decreased_susceptibility_to1.15096295
76MP0005423_abnormal_somatic_nervous1.15081767
77MP0004130_abnormal_muscle_cell1.14050301
78MP0001970_abnormal_pain_threshold1.12788638
79MP0001177_atelectasis1.12594566
80MP0002234_abnormal_pharynx_morphology1.11712888
81MP0002557_abnormal_social/conspecific_i1.11023138
82MP0002733_abnormal_thermal_nociception1.10804867
83MP0009840_abnormal_foam_cell1.10083896
84MP0002998_abnormal_bone_remodeling1.09156016
85MP0003448_altered_tumor_morphology1.08001613
86MP0003646_muscle_fatigue1.07151458
87MP0003045_fibrosis1.06031457
88MP0000747_muscle_weakness1.05291410
89MP0000778_abnormal_nervous_system1.05124104
90MP0003122_maternal_imprinting1.04819096
91MP0005165_increased_susceptibility_to1.03907512
92MP0000733_abnormal_muscle_development1.03483673
93MP0001879_abnormal_lymphatic_vessel1.03474931
94MP0004947_skin_inflammation1.02904779
95MP0002332_abnormal_exercise_endurance1.02781027
96MP0000534_abnormal_ureter_morphology1.01732084
97MP0003633_abnormal_nervous_system1.00821254
98MP0005388_respiratory_system_phenotype0.99517819
99MP0002133_abnormal_respiratory_system0.99517819
100MP0002106_abnormal_muscle_physiology0.99508366
101MP0003787_abnormal_imprinting0.99285942
102MP0003075_altered_response_to0.99020589
103MP0000858_altered_metastatic_potential0.98779781
104MP0004924_abnormal_behavior0.98665393
105MP0005386_behavior/neurological_phenoty0.98665393
106MP0004272_abnormal_basement_membrane0.98317635
107MP0003172_abnormal_lysosome_physiology0.97247012
108MP0002066_abnormal_motor_capabilities/c0.97144277
109MP0005369_muscle_phenotype0.96955497
110MP0005508_abnormal_skeleton_morphology0.96804469
111MP0002269_muscular_atrophy0.96397615
112MP0001299_abnormal_eye_distance/0.95676598
113MP0000759_abnormal_skeletal_muscle0.95615374
114MP0005646_abnormal_pituitary_gland0.95361570
115MP0001533_abnormal_skeleton_physiology0.95293557
116MP0000955_abnormal_spinal_cord0.94500748
117MP0002168_other_aberrant_phenotype0.94499539
118MP0000569_abnormal_digit_pigmentation0.93884253
119MP0002295_abnormal_pulmonary_circulatio0.93706627
120MP0001915_intracranial_hemorrhage0.93459663
121MP0001243_abnormal_dermal_layer0.92303341
122MP0003453_abnormal_keratinocyte_physiol0.91397739
123MP0002882_abnormal_neuron_morphology0.90731157
124MP0005390_skeleton_phenotype0.90246182
125MP0009384_cardiac_valve_regurgitation0.89470243
126MP0000750_abnormal_muscle_regeneration0.89452301
127MP0001544_abnormal_cardiovascular_syste0.89411773
128MP0005385_cardiovascular_system_phenoty0.89411773
129MP0002108_abnormal_muscle_morphology0.89192491
130MP0005621_abnormal_cell_physiology0.88235362
131MP0005595_abnormal_vascular_smooth0.88016065
132MP0005076_abnormal_cell_differentiation0.87902022
133MP0003091_abnormal_cell_migration0.87126035
134MP0001502_abnormal_circadian_rhythm0.85819229
135MP0010630_abnormal_cardiac_muscle0.85025794
136MP0003566_abnormal_cell_adhesion0.84831965
137MP0003631_nervous_system_phenotype0.82806559
138MP0000003_abnormal_adipose_tissue0.82670297
139MP0010368_abnormal_lymphatic_system0.82636424
140MP0000604_amyloidosis0.81721555
141MP0005166_decreased_susceptibility_to0.81023280
142MP0008961_abnormal_basal_metabolism0.80987854
143MP0000920_abnormal_myelination0.79857128
144MP0002128_abnormal_blood_circulation0.78233662
145MP0002089_abnormal_postnatal_growth/wei0.77966233
146MP0000343_altered_response_to0.77265368
147MP0001614_abnormal_blood_vessel0.76806457
148MP0004883_abnormal_blood_vessel0.75891074
149MP0004134_abnormal_chest_morphology0.73473492
150MP0001851_eye_inflammation0.72211208
151MP0008874_decreased_physiological_sensi0.72181212
152MP0010386_abnormal_urinary_bladder0.71189831
153MP0005464_abnormal_platelet_physiology0.70927846
154MP0002933_joint_inflammation0.70120967
155MP0008004_abnormal_stomach_pH0.70047946
156MP0000537_abnormal_urethra_morphology0.67578511
157MP0003795_abnormal_bone_structure0.67085613
158MP0000762_abnormal_tongue_morphology0.67045167
159MP0000249_abnormal_blood_vessel0.65952985
160MP0002925_abnormal_cardiovascular_devel0.65700203
161MP0005083_abnormal_biliary_tract0.63110073
162MP0005058_abnormal_lysosome_morphology0.61505543
163MP0003634_abnormal_glial_cell0.58473590
164MP0009053_abnormal_anal_canal0.58414113

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.65134696
2Myokymia (HP:0002411)4.45793274
3Focal seizures (HP:0007359)4.35618379
4Sudden death (HP:0001699)4.28769668
5Arterial tortuosity (HP:0005116)4.17118059
6Epileptic encephalopathy (HP:0200134)3.71467468
7Visual hallucinations (HP:0002367)3.56262774
8Atonic seizures (HP:0010819)3.47131187
9Febrile seizures (HP:0002373)3.41748420
10Progressive cerebellar ataxia (HP:0002073)3.31884179
11Spondylolisthesis (HP:0003302)3.29666277
12Bundle branch block (HP:0011710)3.26718862
13Peritonitis (HP:0002586)3.25605671
14Ventricular fibrillation (HP:0001663)3.22788972
15Atrial fibrillation (HP:0005110)3.20047899
16Action tremor (HP:0002345)3.18473521
17Right ventricular cardiomyopathy (HP:0011663)3.16179901
18Syncope (HP:0001279)3.15724575
19Wormian bones (HP:0002645)3.13683655
20Primary atrial arrhythmia (HP:0001692)3.10431634
21Ankle contracture (HP:0006466)3.08922825
22Osteolytic defects of the hand bones (HP:0009699)3.00500566
23Osteolytic defects of the phalanges of the hand (HP:0009771)3.00500566
24Protrusio acetabuli (HP:0003179)2.99725118
25Exercise-induced myalgia (HP:0003738)2.91293882
26Abnormality of the calf musculature (HP:0001430)2.91273618
27Supraventricular tachycardia (HP:0004755)2.88329348
28Supraventricular arrhythmia (HP:0005115)2.87599461
29Ventricular arrhythmia (HP:0004308)2.87154595
30Genu recurvatum (HP:0002816)2.86775773
31Mitral valve prolapse (HP:0001634)2.82797094
32Cervical subluxation (HP:0003308)2.81949843
33Spinal rigidity (HP:0003306)2.80149517
34Generalized tonic-clonic seizures (HP:0002069)2.80052709
35Premature rupture of membranes (HP:0001788)2.79122051
36Absence seizures (HP:0002121)2.78342472
37Prolonged QT interval (HP:0001657)2.74545714
38Broad metatarsal (HP:0001783)2.72373538
39Soft skin (HP:0000977)2.69505018
40Dysmetric saccades (HP:0000641)2.68638562
41Gaze-evoked nystagmus (HP:0000640)2.68632462
42Follicular hyperkeratosis (HP:0007502)2.65514662
43Shallow orbits (HP:0000586)2.65461959
44Vertebral compression fractures (HP:0002953)2.62648184
45Aneurysm (HP:0002617)2.57679777
46Blue sclerae (HP:0000592)2.57281304
47Abnormal EKG (HP:0003115)2.53112275
48Mildly elevated creatine phosphokinase (HP:0008180)2.52661194
49Type 1 muscle fiber predominance (HP:0003803)2.52007404
50Dysdiadochokinesis (HP:0002075)2.51803301
51Short nail (HP:0001799)2.51223325
52Dialeptic seizures (HP:0011146)2.50630091
53Impaired vibration sensation in the lower limbs (HP:0002166)2.49857842
54Genetic anticipation (HP:0003743)2.49712851
55Hemiplegia (HP:0002301)2.46369623
56Mitral stenosis (HP:0001718)2.44954454
57Abnormality of the left ventricular outflow tract (HP:0011103)2.43337438
58Subaortic stenosis (HP:0001682)2.43337438
59Lower limb amyotrophy (HP:0007210)2.39669505
60Broad-based gait (HP:0002136)2.39354673
61Poor eye contact (HP:0000817)2.38558853
62Neonatal short-limb short stature (HP:0008921)2.37703367
63Hyperextensible skin (HP:0000974)2.37539591
64Broad face (HP:0000283)2.32602146
65Increased variability in muscle fiber diameter (HP:0003557)2.31165740
66Ventricular tachycardia (HP:0004756)2.30248885
67Calf muscle hypertrophy (HP:0008981)2.30147487
68Mitral regurgitation (HP:0001653)2.29788600
69Depression (HP:0000716)2.26711418
70Obstructive sleep apnea (HP:0002870)2.26526311
71Abnormality of the lower motor neuron (HP:0002366)2.26469796
72Hyporeflexia of lower limbs (HP:0002600)2.25749331
73Exercise-induced muscle cramps (HP:0003710)2.25663500
74Abnormality of dentin (HP:0010299)2.25575860
75Joint laxity (HP:0001388)2.25232504
76Aortic regurgitation (HP:0001659)2.21695083
77EMG: myopathic abnormalities (HP:0003458)2.20379040
78Dysmetria (HP:0001310)2.20354969
79Difficulty climbing stairs (HP:0003551)2.19228985
80Cerebral aneurysm (HP:0004944)2.18471801
81Impaired social interactions (HP:0000735)2.18171517
82Abnormal social behavior (HP:0012433)2.18171517
83Disproportionate tall stature (HP:0001519)2.16045499
84Muscle fiber splitting (HP:0003555)2.15930713
85Hyperventilation (HP:0002883)2.15890105
86Cerebral inclusion bodies (HP:0100314)2.15292671
87Bradycardia (HP:0001662)2.15166070
88Ulnar bowing (HP:0003031)2.15004817
89Impaired smooth pursuit (HP:0007772)2.14571612
90Abnormal atrioventricular conduction (HP:0005150)2.12264214
91Distal lower limb amyotrophy (HP:0008944)2.11986906
92Myotonia (HP:0002486)2.11587362
93Slender build (HP:0001533)2.11518384
94Muscle hypertrophy of the lower extremities (HP:0008968)2.11212518
95Increased connective tissue (HP:0009025)2.09110158
96Heart block (HP:0012722)2.08977418
97Amblyopia (HP:0000646)2.06472143
98Absent frontal sinuses (HP:0002688)2.04551592
99Aplasia involving bones of the upper limbs (HP:0009823)2.00784154
100Aplasia of the phalanges of the hand (HP:0009802)2.00784154
101Aplasia involving bones of the extremities (HP:0009825)2.00784154
102Overgrowth (HP:0001548)1.99311818
103Postural instability (HP:0002172)1.99030183
104Neurofibrillary tangles (HP:0002185)1.98694326
105Syringomyelia (HP:0003396)1.97934897
106Spinal cord lesions (HP:0100561)1.97934897
107Atrophic scars (HP:0001075)1.97097462
108Cardiovascular calcification (HP:0011915)1.96915643
109Aortic dissection (HP:0002647)1.96221578
110Bowel diverticulosis (HP:0005222)1.95286300
111Difficulty running (HP:0009046)1.95276654
112Dilatation of the ascending aorta (HP:0005111)1.93990878
113Aortic aneurysm (HP:0004942)1.93883877
114Urinary bladder sphincter dysfunction (HP:0002839)1.92842021
115Abnormality of skeletal muscle fiber size (HP:0012084)1.92365745
116Truncal ataxia (HP:0002078)1.91633903
117Abnormality of the acetabulum (HP:0003170)1.90174927
118Anxiety (HP:0000739)1.89937383
119Hand muscle atrophy (HP:0009130)1.88201775
120Vascular tortuosity (HP:0004948)1.86473803
121Hypoventilation (HP:0002791)1.86433314
122Bladder diverticulum (HP:0000015)1.85503726
123Asymmetric septal hypertrophy (HP:0001670)1.83495486
124Abnormality of oral frenula (HP:0000190)1.83093677
125Lipoatrophy (HP:0100578)1.82840041
126Coxa vara (HP:0002812)1.82579609
127Fragile skin (HP:0001030)1.81931461
128Elbow flexion contracture (HP:0002987)1.81540949
129Supranuclear gaze palsy (HP:0000605)1.81442049
130Scanning speech (HP:0002168)1.81142770
131Interstitial pulmonary disease (HP:0006530)1.80965240
132Insomnia (HP:0100785)1.80328559
133Polycythemia (HP:0001901)1.78547930
134Pointed chin (HP:0000307)1.78333048
135Hemiparesis (HP:0001269)1.78165248
136Papilledema (HP:0001085)1.77861736
137Thin bony cortex (HP:0002753)1.76682975
138Abnormality of ocular smooth pursuit (HP:0000617)1.76659279
139Striae distensae (HP:0001065)1.74757005
140Mild short stature (HP:0003502)1.73880309
141Biconcave vertebral bodies (HP:0004586)1.73669893
142Stereotypic behavior (HP:0000733)1.73614454
143Impaired vibratory sensation (HP:0002495)1.73567271
144Abnormal delivery (HP:0001787)1.73271747
145Epileptiform EEG discharges (HP:0011182)1.71511459
146Ankle clonus (HP:0011448)1.71411084
147Ankyloglossia (HP:0010296)1.71205021
148Scapular winging (HP:0003691)1.71121876
149Increased mean platelet volume (HP:0011877)1.70801854
150Fetal akinesia sequence (HP:0001989)1.70108242
151Aortic valve stenosis (HP:0001650)1.70095469
152Distal upper limb amyotrophy (HP:0007149)1.69609670
153Upper limb amyotrophy (HP:0009129)1.69609670
154Wrist flexion contracture (HP:0001239)1.69135225
155Distal lower limb muscle weakness (HP:0009053)1.68634996
156Hyperacusis (HP:0010780)1.68080696
157Ectopia lentis (HP:0001083)1.66359022
158Round ear (HP:0100830)1.65530783
159Tibial bowing (HP:0002982)1.64927706
160Spinal cord compression (HP:0002176)1.64557441
161Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63484967
162Hypoplasia of the iris (HP:0007676)1.62913189
163Abnormal platelet volume (HP:0011876)1.62533219
164Osteoarthritis (HP:0002758)1.60708171
165Bowing of the arm (HP:0006488)1.60645597
166Bowed forearm bones (HP:0003956)1.60645597
167Achilles tendon contracture (HP:0001771)1.60288078
168Relative macrocephaly (HP:0004482)1.59187454
169Long toe (HP:0010511)1.58825801
170Radial bowing (HP:0002986)1.58150539
171Myocardial infarction (HP:0001658)1.56636412
172Joint stiffness (HP:0001387)1.56359538
173Diplopia (HP:0000651)1.55067569
174Abnormality of binocular vision (HP:0011514)1.55067569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.23083408
2EPHA43.80068154
3PRKD32.75722424
4MAP3K92.74919660
5DAPK22.58486642
6PAK62.25643155
7MAP3K42.22226657
8MINK12.04495712
9CAMKK12.00236912
10ERN11.97291112
11TGFBR21.92994653
12MST1R1.89755926
13DMPK1.89684527
14PRPF4B1.89009131
15RIPK11.86122750
16MAP2K71.84075753
17KSR21.79568822
18STK381.75791411
19MAP2K31.74570041
20TTN1.68593262
21TRPM71.68355814
22PTK2B1.64409769
23ICK1.64358643
24TESK11.61439571
25LMTK21.60793409
26EPHB11.59439475
27MAP3K31.51682167
28MET1.51267566
29EPHA21.50437684
30MAP2K41.48482220
31PAK31.48403420
32PLK21.44968424
33PAK21.44125157
34TRIB31.40457812
35NEK91.38440721
36IRAK31.37120102
37KSR11.34194093
38CAMK11.33777469
39NTRK11.31301128
40DAPK11.29029876
41PAK41.25673395
42CDK51.24950612
43LIMK11.24199214
44LATS21.22935141
45PHKG21.22750131
46PHKG11.22750131
47CDC42BPA1.22646206
48CASK1.20460625
49DDR21.19691772
50PRKD21.19287770
51MAP3K61.18746138
52NTRK21.15150689
53PDGFRA1.14831890
54PKN21.14027396
55FER1.12842682
56MAP3K21.11842152
57PRKCH1.09662376
58PDGFRB1.09420050
59PRKG21.09030712
60MARK11.08157862
61CAMKK21.06819892
62SIK11.05974538
63CAMK2A1.05140761
64ZAP701.04113820
65MAP3K71.02580104
66PRKCG1.01292982
67RIPK40.99015792
68MYLK0.98921367
69EPHB20.94541686
70RPS6KA20.92347115
71OBSCN0.92269948
72JAK10.91489597
73SGK30.91202625
74TAOK10.89472391
75TNIK0.89377516
76PIK3CA0.89201529
77MAP3K120.87998200
78CDK120.87277820
79LATS10.86963071
80SGK20.85820083
81SCYL20.84474015
82CAMK2D0.83628628
83AKT30.83540326
84GRK50.83232817
85CAMK2B0.82062435
86DAPK30.80972648
87MAP3K130.80018469
88RET0.79496899
89MTOR0.79079188
90MAP3K110.78558481
91STK110.76767974
92MAPK130.76475058
93CDK190.75255390
94PTK20.75096497
95TYRO30.74781530
96CDK180.73905937
97PTK60.73431507
98MAP2K10.73039669
99CDK150.73036994
100SGK4940.72166979
101SGK2230.72166979
102PIK3CG0.71610032
103BMX0.71053659
104PDPK10.70852399
105ROCK10.70234184
106PDK10.70007672
107SGK10.69581945
108CAMK40.68322206
109ERBB40.67319259
110CAMK1G0.67015597
111MAP3K10.64362647
112SIK20.64024203
113ARAF0.63479681
114CDK140.61734004
115PRKCE0.61551360
116PINK10.61440199
117CDK11A0.60559273
118TAOK20.59763296
119MELK0.58782498
120CAMK2G0.58605000
121NEK10.57921015
122UHMK10.57231397
123SMG10.56257981
124BMPR20.56049793
125MOS0.54614681
126ALK0.54408877
127INSRR0.53587381
128MAPK70.51925075
129STK100.51916502
130RAF10.51204206
131STK240.47301134
132RPS6KA30.46855513
133PRKD10.46506367
134MARK20.46045100
135MAPK120.45736451
136WNK10.45499640
137ROCK20.45429525
138JAK30.44706856
139FGFR40.44365257
140HIPK20.44310503
141PDK40.43758955
142PDK30.43758955
143NME10.42978522
144CLK10.41122264
145MAP3K80.40762674

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.75926158
2Circadian entrainment_Homo sapiens_hsa047132.52509302
3Long-term potentiation_Homo sapiens_hsa047202.42365453
4Synaptic vesicle cycle_Homo sapiens_hsa047212.32204214
5Glutamatergic synapse_Homo sapiens_hsa047242.20043530
6Olfactory transduction_Homo sapiens_hsa047402.18710896
7Amphetamine addiction_Homo sapiens_hsa050312.17123585
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.14973756
9Insulin secretion_Homo sapiens_hsa049112.10030876
10Dilated cardiomyopathy_Homo sapiens_hsa054142.04059979
11Salivary secretion_Homo sapiens_hsa049702.01303050
12GABAergic synapse_Homo sapiens_hsa047271.94667667
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.93361424
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92894418
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91573050
16Gastric acid secretion_Homo sapiens_hsa049711.89303337
17Morphine addiction_Homo sapiens_hsa050321.85153870
18Oxytocin signaling pathway_Homo sapiens_hsa049211.74408262
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.72695682
20Dopaminergic synapse_Homo sapiens_hsa047281.64478112
21Cholinergic synapse_Homo sapiens_hsa047251.62508741
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.58794672
23Calcium signaling pathway_Homo sapiens_hsa040201.58038188
24GnRH signaling pathway_Homo sapiens_hsa049121.52003413
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48222467
26Chronic myeloid leukemia_Homo sapiens_hsa052201.47265852
27Renin secretion_Homo sapiens_hsa049241.43498477
28Long-term depression_Homo sapiens_hsa047301.42179444
29Taste transduction_Homo sapiens_hsa047421.41673383
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38526180
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.34200894
32Small cell lung cancer_Homo sapiens_hsa052221.31453411
33Cardiac muscle contraction_Homo sapiens_hsa042601.31318606
34Type II diabetes mellitus_Homo sapiens_hsa049301.29948904
35cAMP signaling pathway_Homo sapiens_hsa040241.29188587
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.28179626
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28148345
38Pancreatic cancer_Homo sapiens_hsa052121.25066873
39Malaria_Homo sapiens_hsa051441.25048012
40Renal cell carcinoma_Homo sapiens_hsa052111.23279062
41Glioma_Homo sapiens_hsa052141.20816181
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19275957
43Gap junction_Homo sapiens_hsa045401.18281564
44Non-small cell lung cancer_Homo sapiens_hsa052231.15787694
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.15598823
46Nitrogen metabolism_Homo sapiens_hsa009101.14602478
47Cocaine addiction_Homo sapiens_hsa050301.14467672
48Estrogen signaling pathway_Homo sapiens_hsa049151.12745095
49Serotonergic synapse_Homo sapiens_hsa047261.11479195
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11369940
51Melanogenesis_Homo sapiens_hsa049161.08311934
52Prion diseases_Homo sapiens_hsa050201.07807558
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06609475
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05819091
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99812534
56ErbB signaling pathway_Homo sapiens_hsa040120.97281950
57Axon guidance_Homo sapiens_hsa043600.95970185
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.93715010
59Focal adhesion_Homo sapiens_hsa045100.92347068
60Pancreatic secretion_Homo sapiens_hsa049720.92316758
61Glucagon signaling pathway_Homo sapiens_hsa049220.91878913
62Thyroid hormone synthesis_Homo sapiens_hsa049180.90563541
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88834326
64TNF signaling pathway_Homo sapiens_hsa046680.88084046
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87137716
66Shigellosis_Homo sapiens_hsa051310.86678617
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85275415
68Salmonella infection_Homo sapiens_hsa051320.84784481
69Osteoclast differentiation_Homo sapiens_hsa043800.84493840
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.84462607
71Acute myeloid leukemia_Homo sapiens_hsa052210.84175841
72Thyroid cancer_Homo sapiens_hsa052160.82485418
73MicroRNAs in cancer_Homo sapiens_hsa052060.80992677
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80312100
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75628880
76Toxoplasmosis_Homo sapiens_hsa051450.74873441
77Dorso-ventral axis formation_Homo sapiens_hsa043200.74734267
78Rap1 signaling pathway_Homo sapiens_hsa040150.73726246
79Melanoma_Homo sapiens_hsa052180.73440170
80ECM-receptor interaction_Homo sapiens_hsa045120.73273167
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.72951120
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71599535
83Pathways in cancer_Homo sapiens_hsa052000.70015110
84Proteoglycans in cancer_Homo sapiens_hsa052050.69162421
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69159957
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68846014
87MAPK signaling pathway_Homo sapiens_hsa040100.68777394
88Hepatitis B_Homo sapiens_hsa051610.67455439
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67120015
90Bile secretion_Homo sapiens_hsa049760.67094662
91VEGF signaling pathway_Homo sapiens_hsa043700.66732338
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66709176
93Amoebiasis_Homo sapiens_hsa051460.66245836
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65453162
95Circadian rhythm_Homo sapiens_hsa047100.65451594
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64845789
97Collecting duct acid secretion_Homo sapiens_hsa049660.64750861
98Prolactin signaling pathway_Homo sapiens_hsa049170.64139633
99Choline metabolism in cancer_Homo sapiens_hsa052310.63499934
100Apoptosis_Homo sapiens_hsa042100.63101283
101Prostate cancer_Homo sapiens_hsa052150.62073695
102Tight junction_Homo sapiens_hsa045300.62027573
103FoxO signaling pathway_Homo sapiens_hsa040680.61535783
104Vibrio cholerae infection_Homo sapiens_hsa051100.60721020
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60457903
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60271195
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.60233348
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60054829
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59858786
110Phagosome_Homo sapiens_hsa041450.59369600
111TGF-beta signaling pathway_Homo sapiens_hsa043500.59006945
112Insulin signaling pathway_Homo sapiens_hsa049100.56849097
113mTOR signaling pathway_Homo sapiens_hsa041500.54369236
114Ras signaling pathway_Homo sapiens_hsa040140.53908307
115Adherens junction_Homo sapiens_hsa045200.53792171
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52030884
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51671927
118Ovarian steroidogenesis_Homo sapiens_hsa049130.51204591
119Inositol phosphate metabolism_Homo sapiens_hsa005620.50867872
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50112432
121Oocyte meiosis_Homo sapiens_hsa041140.47575887
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46922703
123Wnt signaling pathway_Homo sapiens_hsa043100.46714554
124HIF-1 signaling pathway_Homo sapiens_hsa040660.44979412
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44582352
126Endocytosis_Homo sapiens_hsa041440.43722223
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43290320
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42833550
129Platelet activation_Homo sapiens_hsa046110.42500791
130Endometrial cancer_Homo sapiens_hsa052130.42094337
131Protein digestion and absorption_Homo sapiens_hsa049740.39970853
132Mineral absorption_Homo sapiens_hsa049780.38750954
133Bladder cancer_Homo sapiens_hsa052190.38319299
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.37608687
135Insulin resistance_Homo sapiens_hsa049310.37284425

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