MICAL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)4.96645899
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.92083706
3cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.91408796
4locomotory exploration behavior (GO:0035641)3.87966402
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.83230111
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.67388017
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.58757353
8negative regulation of potassium ion transmembrane transport (GO:1901380)3.54852926
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52359521
10cardiac myofibril assembly (GO:0055003)3.52313973
11positive regulation of synapse maturation (GO:0090129)3.52119668
12cell communication by electrical coupling (GO:0010644)3.49616679
13regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.49169920
14cellular response to epinephrine stimulus (GO:0071872)3.47626854
15cellular potassium ion homeostasis (GO:0030007)3.41335358
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.31965609
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.28385437
18cell communication involved in cardiac conduction (GO:0086065)3.26623654
19negative regulation of protein localization to cell surface (GO:2000009)3.25370882
20synaptic vesicle maturation (GO:0016188)3.25064704
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.24664223
22neuronal ion channel clustering (GO:0045161)3.24588934
23cerebellar granule cell differentiation (GO:0021707)3.21020103
24response to epinephrine (GO:0071871)3.17688068
25regulation of cell communication by electrical coupling (GO:0010649)3.16558791
26sarcomere organization (GO:0045214)3.15649225
27plasma membrane repair (GO:0001778)3.12040720
28vocalization behavior (GO:0071625)3.11120290
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.10831706
30semaphorin-plexin signaling pathway (GO:0071526)3.10241215
31myofibril assembly (GO:0030239)3.09935630
32cerebellar Purkinje cell differentiation (GO:0021702)3.02092610
33cytoskeletal anchoring at plasma membrane (GO:0007016)2.98908557
34transmission of nerve impulse (GO:0019226)2.95083740
35neuronal action potential propagation (GO:0019227)2.94109001
36dendritic spine morphogenesis (GO:0060997)2.93227366
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.91648903
38ionotropic glutamate receptor signaling pathway (GO:0035235)2.91062867
39regulation of synapse maturation (GO:0090128)2.90833252
40membrane depolarization during action potential (GO:0086010)2.90269308
41establishment of nucleus localization (GO:0040023)2.89561590
42ventricular cardiac muscle cell action potential (GO:0086005)2.89391015
43regulation of membrane repolarization (GO:0060306)2.88910340
44neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.88291932
45regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.87529811
46detection of calcium ion (GO:0005513)2.85530699
47positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.84575350
48cardiac muscle contraction (GO:0060048)2.84511127
49ensheathment of neurons (GO:0007272)2.83540375
50axon ensheathment (GO:0008366)2.83540375
51myelination (GO:0042552)2.82980950
52gamma-aminobutyric acid transport (GO:0015812)2.82810046
53layer formation in cerebral cortex (GO:0021819)2.81768312
54dendrite morphogenesis (GO:0048813)2.81400360
55regulation of ARF protein signal transduction (GO:0032012)2.81030554
56cellular response to catecholamine stimulus (GO:0071870)2.80772746
57cellular response to monoamine stimulus (GO:0071868)2.80772746
58regulation of actin filament-based movement (GO:1903115)2.79001952
59hemidesmosome assembly (GO:0031581)2.78753676
60cell migration in hindbrain (GO:0021535)2.78569657
61cell-substrate junction assembly (GO:0007044)2.76722100
62axon ensheathment in central nervous system (GO:0032291)2.76065055
63central nervous system myelination (GO:0022010)2.76065055
64positive regulation of action potential (GO:0045760)2.73942133
65peripheral nervous system axon ensheathment (GO:0032292)2.73927962
66myelination in peripheral nervous system (GO:0022011)2.73927962
67adherens junction assembly (GO:0034333)2.73212185
68glutamate secretion (GO:0014047)2.73143694
69negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70538577
70neuron cell-cell adhesion (GO:0007158)2.68845666
71activation of protein kinase A activity (GO:0034199)2.66831809
72regulation of synapse structural plasticity (GO:0051823)2.66256692
73sodium ion export (GO:0071436)2.65933549
74regulation of calcium ion transmembrane transporter activity (GO:1901019)2.65929306
75regulation of calcium ion transmembrane transport (GO:1903169)2.65929306
76cell-substrate adherens junction assembly (GO:0007045)2.65477255
77focal adhesion assembly (GO:0048041)2.65477255
78nerve growth factor signaling pathway (GO:0038180)2.65277434
79glutamate receptor signaling pathway (GO:0007215)2.62938726
80regulation of voltage-gated calcium channel activity (GO:1901385)2.62869687
81cardiac muscle hypertrophy (GO:0003300)2.62662373
82synaptic transmission, glutamatergic (GO:0035249)2.62350550
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62218128
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61235087
85neuromuscular junction development (GO:0007528)2.61072767
86peptidyl-tyrosine autophosphorylation (GO:0038083)2.60603473
87regulation of glutamate receptor signaling pathway (GO:1900449)2.60181823
88regulation of synaptic vesicle exocytosis (GO:2000300)2.59442075
89adult heart development (GO:0007512)2.58748920
90L-amino acid import (GO:0043092)2.57474201
91response to monoamine (GO:0071867)2.57376341
92response to catecholamine (GO:0071869)2.57376341
93insulin-like growth factor receptor signaling pathway (GO:0048009)2.56288736
94positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.55948597
95regulation of dendritic spine morphogenesis (GO:0061001)2.54809596
96multicellular organismal signaling (GO:0035637)2.54441961
97cellular sodium ion homeostasis (GO:0006883)2.54318247
98sarcoplasmic reticulum calcium ion transport (GO:0070296)2.53256675
99presynaptic membrane assembly (GO:0097105)2.52939371
100protein localization to synapse (GO:0035418)2.52864326
101synaptic vesicle exocytosis (GO:0016079)2.52326207
102adult walking behavior (GO:0007628)2.52221667
103positive regulation of sodium ion transport (GO:0010765)2.51310080
104amino acid import (GO:0043090)2.51039618
105positive regulation of potassium ion transmembrane transport (GO:1901381)2.50974630
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.50892776
107potassium ion import (GO:0010107)2.50710723
108carnitine shuttle (GO:0006853)2.50579524
109striated muscle hypertrophy (GO:0014897)2.50409087
110exploration behavior (GO:0035640)2.49769825
111neuron recognition (GO:0008038)2.48997651
112membrane tubulation (GO:0097320)2.48659468
113neuromuscular process controlling balance (GO:0050885)2.46898433
114regulation of cardiac muscle cell contraction (GO:0086004)2.45056386
115glucocorticoid receptor signaling pathway (GO:0042921)2.43278072
116regulation of neuronal synaptic plasticity (GO:0048168)2.42434829
117postsynaptic membrane organization (GO:0001941)2.42255695
118regulation of the force of heart contraction (GO:0002026)2.38851830
119regulation of NFAT protein import into nucleus (GO:0051532)2.37629654
120neurotransmitter secretion (GO:0007269)2.34832482
121relaxation of cardiac muscle (GO:0055119)2.31756961
122dendritic spine organization (GO:0097061)2.30477752
123auditory behavior (GO:0031223)2.29821939
124positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.29021347
125regulation of fatty acid beta-oxidation (GO:0031998)2.28960517
126cell volume homeostasis (GO:0006884)2.28432691
127negative regulation of myotube differentiation (GO:0010832)2.26026121
128potassium ion homeostasis (GO:0055075)2.23497793
129lung epithelium development (GO:0060428)2.22681684
130cardiac conduction (GO:0061337)2.21605288
131positive regulation of CREB transcription factor activity (GO:0032793)2.21327454
132cardiac muscle adaptation (GO:0014887)2.20877142
133cardiac muscle hypertrophy in response to stress (GO:0014898)2.20877142
134muscle hypertrophy in response to stress (GO:0003299)2.20877142
135positive regulation of dendrite development (GO:1900006)2.20096638
136neurotransmitter-gated ion channel clustering (GO:0072578)2.19091707
137neural tube development (GO:0021915)2.19028043
138protein targeting to plasma membrane (GO:0072661)2.17928722
139camera-type eye morphogenesis (GO:0048593)2.17578116
140desmosome organization (GO:0002934)2.17334275
141cell-cell junction maintenance (GO:0045217)2.17000727
142negative regulation of catenin import into nucleus (GO:0035414)2.16120861
143actomyosin structure organization (GO:0031032)2.15308010
144regulation of ARF GTPase activity (GO:0032312)2.14329710
145cell junction maintenance (GO:0034331)2.13689997
146negative regulation of fatty acid transport (GO:2000192)2.11429456
147regulation of sodium ion transport (GO:0002028)2.11176388
148metanephric nephron tubule development (GO:0072234)2.10325957
149metanephric tubule development (GO:0072170)2.10325957
150regulation of hippo signaling (GO:0035330)2.08802560
151regulation of axon extension involved in axon guidance (GO:0048841)2.08758277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.01028858
2GBX2_23144817_ChIP-Seq_PC3_Human2.64586016
3DROSHA_22980978_ChIP-Seq_HELA_Human2.59717577
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34895440
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31753137
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20867527
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15749139
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15749139
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05991109
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.00551537
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98765789
12EZH2_27304074_Chip-Seq_ESCs_Mouse1.95663086
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93891101
14RARB_27405468_Chip-Seq_BRAIN_Mouse1.93161957
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90520155
16* EP300_21415370_ChIP-Seq_HL-1_Mouse1.89140850
17* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88446007
18* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.86880284
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.85536390
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82974184
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.82577104
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82096432
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77746299
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77301299
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73433124
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73198752
27REST_21632747_ChIP-Seq_MESCs_Mouse1.72705850
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69296531
29LXR_22292898_ChIP-Seq_THP-1_Human1.66871910
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.65708237
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64388741
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.62737673
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53121861
34AR_21572438_ChIP-Seq_LNCaP_Human1.53033843
35AHR_22903824_ChIP-Seq_MCF-7_Human1.46118683
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45831940
37* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44420219
38* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.44285181
39* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43694665
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43559309
41SMC4_20622854_ChIP-Seq_HELA_Human1.43050981
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42025205
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41124222
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40706107
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39652248
46* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38934259
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38812472
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37670103
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.36837159
50TP53_23651856_ChIP-Seq_MEFs_Mouse1.34010738
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.32990706
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31946622
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.31353914
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30352741
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.30185327
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29970947
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29517451
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28612919
59* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27657525
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27271773
61KDM2B_26808549_Chip-Seq_K562_Human1.26580056
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25453512
63STAT3_23295773_ChIP-Seq_U87_Human1.25218132
64RACK7_27058665_Chip-Seq_MCF-7_Human1.23777619
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.22375470
66AR_19668381_ChIP-Seq_PC3_Human1.21847095
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21827143
68KDM2B_26808549_Chip-Seq_DND41_Human1.21800909
69TET1_21490601_ChIP-Seq_MESCs_Mouse1.21703948
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21391548
71TP53_16413492_ChIP-PET_HCT116_Human1.20863915
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.20294966
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.18982687
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16996054
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16828303
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16815076
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15475590
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14718345
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14296929
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14263594
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13566518
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.13466297
83* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13430966
84TAF15_26573619_Chip-Seq_HEK293_Human1.13068022
85* TCF4_23295773_ChIP-Seq_U87_Human1.12955127
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.12399097
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.12209842
88* TBX20_22080862_ChIP-Seq_HEART_Mouse1.11971002
89* TBX20_22328084_ChIP-Seq_HEART_Mouse1.11971002
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11640512
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10332660
92TP53_22127205_ChIP-Seq_IMR90_Human1.10230402
93CREB1_26743006_Chip-Seq_LNCaP_Human1.09795979
94* SMAD4_21741376_ChIP-Seq_HESCs_Human1.09793042
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09663632
96* ISL1_27105846_Chip-Seq_CPCs_Mouse1.09027437
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08798496
98TCF7_22412390_ChIP-Seq_EML_Mouse1.08736925
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.07964747
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.07610676
101ZNF274_21170338_ChIP-Seq_K562_Hela1.07289832
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07171364
103SMAD3_21741376_ChIP-Seq_HESCs_Human1.06841671
104* MITF_21258399_ChIP-Seq_MELANOMA_Human1.03919690
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.03880138
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03419025
107* TP63_22573176_ChIP-Seq_HFKS_Human1.02807463
108* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02776581
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02484092
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02478895
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02434365
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.02327038
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02056049
114OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00991860
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00950151
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00887444
117* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00742491
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00061851
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00061851
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00013580
121P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98125475
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.97407366
123TBL1_22424771_ChIP-Seq_293T_Human0.97046374
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96839092
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94939145
126EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94698058
127CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94385374
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94224532
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93644683
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93588292
131* FOXA2_19822575_ChIP-Seq_HepG2_Human0.93358369
132ELK3_25401928_ChIP-Seq_HUVEC_Human0.91110845
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90986631
134CBX2_27304074_Chip-Seq_ESCs_Mouse0.90953036
135GATA1_19941826_ChIP-Seq_K562_Human0.89953835
136CTCF_27219007_Chip-Seq_Bcells_Human0.87303279
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.86830609
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86796831
139TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85709711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.07414747
2MP0002837_dystrophic_cardiac_calcinosis3.66195894
3MP0000751_myopathy3.46228818
4MP0004270_analgesia2.78871285
5MP0004215_abnormal_myocardial_fiber2.78804904
6MP0004084_abnormal_cardiac_muscle2.72862169
7MP0003705_abnormal_hypodermis_morpholog2.69452137
8MP0009046_muscle_twitch2.62604179
9MP0003880_abnormal_central_pattern2.62125836
10MP0004145_abnormal_muscle_electrophysio2.49818498
11MP0003635_abnormal_synaptic_transmissio2.46692444
12MP0004036_abnormal_muscle_relaxation2.37582150
13MP0003137_abnormal_impulse_conducting2.04952777
14MP0001486_abnormal_startle_reflex2.01850887
15MP0003646_muscle_fatigue2.01728542
16MP0002064_seizures2.01355967
17MP0000749_muscle_degeneration1.97096267
18MP0009745_abnormal_behavioral_response1.95669242
19MP0002272_abnormal_nervous_system1.93245320
20MP0001348_abnormal_lacrimal_gland1.90540300
21MP0005330_cardiomyopathy1.86508680
22MP0003879_abnormal_hair_cell1.84718990
23MP0004087_abnormal_muscle_fiber1.81094510
24MP0002063_abnormal_learning/memory/cond1.80980871
25MP0004510_myositis1.74713314
26MP0000920_abnormal_myelination1.73919048
27MP0008775_abnormal_heart_ventricle1.72560503
28MP0004130_abnormal_muscle_cell1.71727265
29MP0002734_abnormal_mechanical_nocicepti1.66845787
30MP0000579_abnormal_nail_morphology1.64181281
31MP0002249_abnormal_larynx_morphology1.62463132
32MP0005623_abnormal_meninges_morphology1.62369142
33MP0005620_abnormal_muscle_contractility1.61591973
34MP0004885_abnormal_endolymph1.59171189
35MP0000747_muscle_weakness1.57777872
36MP0004085_abnormal_heartbeat1.56277910
37MP0001440_abnormal_grooming_behavior1.55986857
38MP0005423_abnormal_somatic_nervous1.55328707
39MP0002572_abnormal_emotion/affect_behav1.54740562
40MP0006138_congestive_heart_failure1.53612668
41MP0002972_abnormal_cardiac_muscle1.52862780
42MP0000778_abnormal_nervous_system1.52604701
43MP0005171_absent_coat_pigmentation1.51830791
44MP0008569_lethality_at_weaning1.51463267
45MP0003566_abnormal_cell_adhesion1.51374736
46MP0009780_abnormal_chondrocyte_physiolo1.49452141
47MP0001502_abnormal_circadian_rhythm1.43608915
48MP0002106_abnormal_muscle_physiology1.41636883
49MP0002269_muscular_atrophy1.41108406
50MP0000569_abnormal_digit_pigmentation1.40682339
51MP0005670_abnormal_white_adipose1.40587513
52MP0000733_abnormal_muscle_development1.38759746
53MP0003091_abnormal_cell_migration1.37812261
54MP0002067_abnormal_sensory_capabilities1.36538797
55MP0003690_abnormal_glial_cell1.36192447
56MP0003329_amyloid_beta_deposits1.35220095
57MP0004924_abnormal_behavior1.34039034
58MP0005386_behavior/neurological_phenoty1.34039034
59MP0003045_fibrosis1.32994171
60MP0010630_abnormal_cardiac_muscle1.29376614
61MP0005369_muscle_phenotype1.27406058
62MP0005076_abnormal_cell_differentiation1.26578145
63MP0009384_cardiac_valve_regurgitation1.24872419
64MP0000003_abnormal_adipose_tissue1.24147120
65MP0004233_abnormal_muscle_weight1.23700031
66MP0005257_abnormal_intraocular_pressure1.23692159
67MP0005666_abnormal_adipose_tissue1.22929101
68MP0000759_abnormal_skeletal_muscle1.22027087
69MP0004484_altered_response_of1.21487259
70MP0001968_abnormal_touch/_nociception1.20525079
71MP0003279_aneurysm1.19463629
72MP0005375_adipose_tissue_phenotype1.17632667
73MP0000534_abnormal_ureter_morphology1.17221051
74MP0005410_abnormal_fertilization1.15989637
75MP0000955_abnormal_spinal_cord1.15148229
76MP0002089_abnormal_postnatal_growth/wei1.14687294
77MP0005385_cardiovascular_system_phenoty1.14243166
78MP0001544_abnormal_cardiovascular_syste1.14243166
79MP0001485_abnormal_pinna_reflex1.13594812
80MP0000537_abnormal_urethra_morphology1.12848191
81MP0004185_abnormal_adipocyte_glucose1.11917241
82MP0002184_abnormal_innervation1.11737119
83MP0001958_emphysema1.11491303
84MP0001849_ear_inflammation1.10861654
85MP0002735_abnormal_chemical_nociception1.10012875
86MP0010368_abnormal_lymphatic_system1.09995371
87MP0003950_abnormal_plasma_membrane1.09064743
88MP0002882_abnormal_neuron_morphology1.08606868
89MP0000750_abnormal_muscle_regeneration1.08214460
90MP0002108_abnormal_muscle_morphology1.08016612
91MP0003634_abnormal_glial_cell1.07726271
92MP0002066_abnormal_motor_capabilities/c1.07569155
93MP0002733_abnormal_thermal_nociception1.06262465
94MP0004043_abnormal_pH_regulation1.06054550
95MP0003632_abnormal_nervous_system1.05284127
96MP0004742_abnormal_vestibular_system1.04000098
97MP0001501_abnormal_sleep_pattern1.03772823
98MP0005503_abnormal_tendon_morphology1.03062788
99MP0001299_abnormal_eye_distance/1.02752864
100MP0001970_abnormal_pain_threshold1.02515190
101MP0002822_catalepsy1.01172218
102MP0000566_synostosis1.00550350
103MP0000013_abnormal_adipose_tissue0.98273617
104MP0003787_abnormal_imprinting0.98102749
105MP0002909_abnormal_adrenal_gland0.96547030
106MP0004147_increased_porphyrin_level0.95618754
107MP0004272_abnormal_basement_membrane0.95405441
108MP0004811_abnormal_neuron_physiology0.93835178
109MP0004858_abnormal_nervous_system0.92005147
110MP0003631_nervous_system_phenotype0.91068040
111MP0002229_neurodegeneration0.90705667
112MP0003633_abnormal_nervous_system0.89434975
113MP0001984_abnormal_olfaction0.86856310
114MP0002152_abnormal_brain_morphology0.84514974
115MP0003283_abnormal_digestive_organ0.83342173
116MP0002557_abnormal_social/conspecific_i0.83119274
117MP0005023_abnormal_wound_healing0.81489431
118MP0001661_extended_life_span0.81108638
119MP0004142_abnormal_muscle_tone0.80585208
120MP0002168_other_aberrant_phenotype0.80352522
121MP0001270_distended_abdomen0.78075219
122MP0000762_abnormal_tongue_morphology0.76394605
123MP0002127_abnormal_cardiovascular_syste0.75211476
124MP0005360_urolithiasis0.75071253
125MP0008438_abnormal_cutaneous_collagen0.68688369
126MP0005187_abnormal_penis_morphology0.68056813
127MP0000462_abnormal_digestive_system0.65726437
128MP0003221_abnormal_cardiomyocyte_apopto0.65144901
129MP0008961_abnormal_basal_metabolism0.64441570
130MP0005409_darkened_coat_color0.63127545

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.26236711
2Obstructive sleep apnea (HP:0002870)4.14539425
3Hyporeflexia of lower limbs (HP:0002600)3.95566788
4Muscle fiber splitting (HP:0003555)3.58739962
5Action tremor (HP:0002345)3.55127823
6Bundle branch block (HP:0011710)3.53154282
7Syncope (HP:0001279)3.50907689
8Exercise-induced myalgia (HP:0003738)3.49675500
9Calf muscle hypertrophy (HP:0008981)3.48435178
10Atrial fibrillation (HP:0005110)3.47669414
11Prolonged QT interval (HP:0001657)3.46120926
12Muscle hypertrophy of the lower extremities (HP:0008968)3.40967046
13Difficulty running (HP:0009046)3.38183515
14Myokymia (HP:0002411)3.34780541
15Focal seizures (HP:0007359)3.32026042
16Primary atrial arrhythmia (HP:0001692)3.25195013
17Focal motor seizures (HP:0011153)3.24403502
18Abnormality of the calf musculature (HP:0001430)3.22774262
19Ventricular fibrillation (HP:0001663)3.05858457
20Abnormality of the corticospinal tract (HP:0002492)3.01219897
21Cerebral aneurysm (HP:0004944)3.00743793
22Supraventricular tachycardia (HP:0004755)2.99574932
23Hyperacusis (HP:0010780)2.97117093
24Broad face (HP:0000283)2.96584404
25Supraventricular arrhythmia (HP:0005115)2.96534880
26Dysmetric saccades (HP:0000641)2.96011203
27Progressive cerebellar ataxia (HP:0002073)2.91179838
28Ventricular tachycardia (HP:0004756)2.90398086
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.89288763
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.89288763
31Shallow orbits (HP:0000586)2.84899897
32Gaze-evoked nystagmus (HP:0000640)2.83088117
33Atonic seizures (HP:0010819)2.77296406
34Insidious onset (HP:0003587)2.76073198
35Termporal pattern (HP:0011008)2.76073198
36Dysmetria (HP:0001310)2.75362171
37Febrile seizures (HP:0002373)2.74196226
38Dysdiadochokinesis (HP:0002075)2.74184518
39Sensory axonal neuropathy (HP:0003390)2.72300102
40Ventricular arrhythmia (HP:0004308)2.65891395
41Urinary bladder sphincter dysfunction (HP:0002839)2.65156597
42Intention tremor (HP:0002080)2.64834434
43Ulnar bowing (HP:0003031)2.63146400
44Right ventricular cardiomyopathy (HP:0011663)2.62924073
45Abnormal EKG (HP:0003115)2.62286422
46Bronchomalacia (HP:0002780)2.61333865
47Spastic gait (HP:0002064)2.58408227
48Heart block (HP:0012722)2.51887696
49Scanning speech (HP:0002168)2.48975524
50Epileptic encephalopathy (HP:0200134)2.45521506
51Myotonia (HP:0002486)2.43204127
52Supranuclear gaze palsy (HP:0000605)2.43078130
53Genetic anticipation (HP:0003743)2.42404763
54Onion bulb formation (HP:0003383)2.40997035
55Broad-based gait (HP:0002136)2.40642292
56Distal upper limb amyotrophy (HP:0007149)2.40024538
57Upper limb amyotrophy (HP:0009129)2.40024538
58EMG: myopathic abnormalities (HP:0003458)2.38900398
59Lipoatrophy (HP:0100578)2.37381626
60Exercise-induced muscle cramps (HP:0003710)2.37182170
61Stridor (HP:0010307)2.34287520
62Neurofibrillary tangles (HP:0002185)2.33281786
63Subaortic stenosis (HP:0001682)2.30716031
64Abnormality of the left ventricular outflow tract (HP:0011103)2.30716031
65Impaired social interactions (HP:0000735)2.27840399
66Abnormal social behavior (HP:0012433)2.27840399
67Abnormal atrioventricular conduction (HP:0005150)2.27452999
68Atrioventricular block (HP:0001678)2.27293922
69Lower limb muscle weakness (HP:0007340)2.26941848
70Cerebral inclusion bodies (HP:0100314)2.24191938
71Pheochromocytoma (HP:0002666)2.23240394
72Visual hallucinations (HP:0002367)2.23032915
73Atrophic scars (HP:0001075)2.22887508
74Protrusio acetabuli (HP:0003179)2.22848340
75Hypoplasia of the iris (HP:0007676)2.22404358
76Impaired vibration sensation in the lower limbs (HP:0002166)2.19809100
77Increased variability in muscle fiber diameter (HP:0003557)2.18846098
78Poor eye contact (HP:0000817)2.18805904
79Distal lower limb amyotrophy (HP:0008944)2.18407203
80Ankle clonus (HP:0011448)2.17058067
81Lower limb amyotrophy (HP:0007210)2.15449501
82Steppage gait (HP:0003376)2.15215311
83Abnormality of the fingertips (HP:0001211)2.09530008
84Increased connective tissue (HP:0009025)2.09283252
85Postural instability (HP:0002172)2.08649281
86Broad metatarsal (HP:0001783)2.08052215
87Urinary urgency (HP:0000012)2.07525215
88Alacrima (HP:0000522)2.07227808
89Scapular winging (HP:0003691)2.06974534
90Dilated cardiomyopathy (HP:0001644)2.00175583
91Hypoplastic ischia (HP:0003175)1.98581665
92Generalized tonic-clonic seizures (HP:0002069)1.98569611
93Hammertoe (HP:0001765)1.98115040
94Foot dorsiflexor weakness (HP:0009027)1.96464006
95Hypopigmentation of the fundus (HP:0007894)1.96019263
96Abnormality of the foot musculature (HP:0001436)1.95710787
97Hemiplegia (HP:0002301)1.94003837
98Mildly elevated creatine phosphokinase (HP:0008180)1.93470682
99Aplasia involving bones of the extremities (HP:0009825)1.92031701
100Aplasia involving bones of the upper limbs (HP:0009823)1.92031701
101Aplasia of the phalanges of the hand (HP:0009802)1.92031701
102Hemiparesis (HP:0001269)1.91603461
103Insomnia (HP:0100785)1.89816526
104Type 1 muscle fiber predominance (HP:0003803)1.89071523
105Heterotopia (HP:0002282)1.88747654
106Hyperkalemia (HP:0002153)1.87822381
107Myoglobinuria (HP:0002913)1.87166542
108Laryngomalacia (HP:0001601)1.86977726
109Truncal ataxia (HP:0002078)1.86605068
110Turricephaly (HP:0000262)1.86231465
111Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.86214976
112Neoplasm of the heart (HP:0100544)1.84604434
113Urethral obstruction (HP:0000796)1.84165952
114Flat acetabular roof (HP:0003180)1.84034749
115Bell-shaped thorax (HP:0001591)1.83223175
116Vertebral arch anomaly (HP:0008438)1.82577230
117Aortic aneurysm (HP:0004942)1.82175827
118Renovascular hypertension (HP:0100817)1.81949884
119Diplopia (HP:0000651)1.81902741
120Abnormality of binocular vision (HP:0011514)1.81902741
121Blue irides (HP:0000635)1.81784255
122Limited hip movement (HP:0008800)1.80875259
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79162072
124Drooling (HP:0002307)1.78273978
125Excessive salivation (HP:0003781)1.78273978
126Hyperventilation (HP:0002883)1.78029119
127Hand muscle atrophy (HP:0009130)1.77546941
128Absence seizures (HP:0002121)1.76856811
129Depression (HP:0000716)1.76026015
130Macroorchidism (HP:0000053)1.75077581
131Pointed chin (HP:0000307)1.74839389
132EMG: neuropathic changes (HP:0003445)1.74661261
133Dislocated radial head (HP:0003083)1.74213557
134Aneurysm (HP:0002617)1.73873036
135Fragile skin (HP:0001030)1.72956054
136Slow progression (HP:0003677)1.72655659
137Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.71857071
138Neonatal short-limb short stature (HP:0008921)1.71741032
139Difficulty climbing stairs (HP:0003551)1.71652650
140Abnormality of the ischium (HP:0003174)1.71564019
141Sleep apnea (HP:0010535)1.70754835
142Gowers sign (HP:0003391)1.69548325
143Tracheomalacia (HP:0002779)1.69197848
144Long eyelashes (HP:0000527)1.68428219
145Distal lower limb muscle weakness (HP:0009053)1.67650568
146Impaired smooth pursuit (HP:0007772)1.65392759
147Bradycardia (HP:0001662)1.64329561
148Akinesia (HP:0002304)1.64211956
149Abnormality of the radial head (HP:0003995)1.64079732
150Abnormality of the distal phalanx of the thumb (HP:0009617)1.61898265
151Germ cell neoplasia (HP:0100728)1.58824413
152Wormian bones (HP:0002645)1.58082823
153Long toe (HP:0010511)1.56387507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK2.76681194
2STK392.66667405
3TNIK2.61637260
4EEF2K2.44141266
5NTRK32.40169701
6EPHA42.31195212
7PHKG12.20190280
8PHKG22.20190280
9OBSCN2.14588572
10PAK62.10010652
11MAP3K91.97455286
12CAMK1G1.96078456
13PRKD31.88333981
14WNK11.87458599
15MAP3K41.85561078
16DMPK1.83506507
17MARK11.80273293
18TYRO31.75586808
19PKN21.68473306
20EPHB11.68259659
21PKN11.59563990
22LMTK21.58902679
23OXSR11.58115234
24NTRK21.56325462
25TTN1.53968037
26PAK31.52583064
27MST1R1.47754577
28WNK41.47320128
29INSRR1.41098046
30NTRK11.39839051
31PNCK1.37033844
32FGFR21.30674007
33CAMK1D1.30564304
34BCR1.26336490
35DAPK21.25501057
36STK381.23722267
37RIPK11.22868641
38UHMK11.19910400
39EPHA21.19092812
40PDK41.18295644
41PDK31.18295644
42PRPF4B1.17071989
43SMG11.14961889
44CDC42BPA1.11529650
45MAPK121.10815622
46MARK21.10628655
47CDK51.08056963
48PTK2B1.07778051
49MAPK131.05186087
50CAMK2D1.04389812
51SGK4941.03355769
52SGK2231.03355769
53STK111.02730806
54KSR21.01058192
55FGFR40.99566666
56MINK10.98478509
57TRPM70.97468808
58RPS6KA20.97366154
59RET0.96940859
60MAPK110.94249517
61MAP2K40.91715428
62PRKAA20.91395631
63CASK0.89831984
64MAPKAPK30.89606525
65SGK10.89181695
66ROCK20.84814878
67MET0.83747846
68PRKD20.82884264
69CAMK2A0.82234927
70BRD40.82032154
71ROCK10.81219700
72MAP3K70.80033641
73SIK20.79784263
74PRKAA10.78925747
75PRKD10.78564823
76PAK20.78555352
77SGK30.76715994
78PDPK10.75603444
79MAPK100.75324459
80PDGFRA0.74528927
81PIK3CA0.74497670
82GRK50.71384336
83MUSK0.70360469
84ERN10.70165616
85SIK10.70108188
86CAMKK10.69677726
87CAMK10.69384371
88ERBB20.68388226
89PRKCH0.68278561
90MAP3K60.68024409
91MYLK0.67705507
92CAMK2B0.67668496
93TAOK10.66771950
94SGK20.66384271
95CAMK40.63717022
96LATS10.63407211
97NEK60.62902635
98LATS20.61915459
99PTK20.61315473
100BMX0.61149953
101PINK10.60962409
102AKT30.60375682
103MAP2K70.60366219
104ALK0.60044809
105KSR10.58664880
106TRIB30.58261120
107PDGFRB0.58163186
108RPS6KA30.56975960
109MAP2K60.56663998
110MAP3K100.56640475
111PDK10.56137121
112CDK120.55678649
113CSNK1A1L0.55581962
114MAP3K20.55109910
115PRKCE0.53064022
116CAMK2G0.52870558
117FRK0.52199189
118MAP2K10.52166764
119DDR20.51485352
120CDK190.50777118
121DYRK1A0.50507551
122FER0.50034049
123MAP3K130.48486762
124MELK0.48223941
125MTOR0.47501347
126PTK60.47311789
127MAPK150.46599940
128PRKCZ0.46361862
129FGFR30.43569327
130MAPK80.43125796
131MAPK70.42154133

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.23901028
2Glutamatergic synapse_Homo sapiens_hsa047242.03058575
3Nicotine addiction_Homo sapiens_hsa050332.02537343
4Circadian entrainment_Homo sapiens_hsa047132.00646275
5Cardiac muscle contraction_Homo sapiens_hsa042601.97615339
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.92688179
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.89064832
8GABAergic synapse_Homo sapiens_hsa047271.81970064
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.75094390
10Long-term potentiation_Homo sapiens_hsa047201.74444529
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72892555
12Morphine addiction_Homo sapiens_hsa050321.69308589
13Salivary secretion_Homo sapiens_hsa049701.68509719
14Fatty acid biosynthesis_Homo sapiens_hsa000611.61882152
15Type II diabetes mellitus_Homo sapiens_hsa049301.61462927
16Olfactory transduction_Homo sapiens_hsa047401.60567936
17Synaptic vesicle cycle_Homo sapiens_hsa047211.53008477
18Insulin secretion_Homo sapiens_hsa049111.52567104
19Oxytocin signaling pathway_Homo sapiens_hsa049211.49282212
20Axon guidance_Homo sapiens_hsa043601.49134101
21Amphetamine addiction_Homo sapiens_hsa050311.49100560
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.48982831
23Renin secretion_Homo sapiens_hsa049241.48432700
24Gastric acid secretion_Homo sapiens_hsa049711.47487507
25Dorso-ventral axis formation_Homo sapiens_hsa043201.43778761
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43111805
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43031398
28Cholinergic synapse_Homo sapiens_hsa047251.41976972
29Taste transduction_Homo sapiens_hsa047421.40399786
30Dopaminergic synapse_Homo sapiens_hsa047281.35943383
31Calcium signaling pathway_Homo sapiens_hsa040201.35411697
32cAMP signaling pathway_Homo sapiens_hsa040241.28741606
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27098866
34Long-term depression_Homo sapiens_hsa047301.24835570
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22225528
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19179511
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.17033330
38GnRH signaling pathway_Homo sapiens_hsa049121.13796252
39ABC transporters_Homo sapiens_hsa020101.12927208
40Serotonergic synapse_Homo sapiens_hsa047261.09274400
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09014363
42Adherens junction_Homo sapiens_hsa045201.08573991
43Gap junction_Homo sapiens_hsa045401.06532691
44Histidine metabolism_Homo sapiens_hsa003401.05968933
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.02442708
46Fatty acid metabolism_Homo sapiens_hsa012121.02049935
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.01624355
48Estrogen signaling pathway_Homo sapiens_hsa049151.00876425
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00857027
50Cocaine addiction_Homo sapiens_hsa050301.00479214
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99457081
52Notch signaling pathway_Homo sapiens_hsa043300.99394366
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98131193
54ErbB signaling pathway_Homo sapiens_hsa040120.96587166
55Propanoate metabolism_Homo sapiens_hsa006400.95416118
56Arginine biosynthesis_Homo sapiens_hsa002200.94542122
57Renal cell carcinoma_Homo sapiens_hsa052110.93877660
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91788554
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91787771
60Glucagon signaling pathway_Homo sapiens_hsa049220.90227692
61Tight junction_Homo sapiens_hsa045300.89111548
62Melanogenesis_Homo sapiens_hsa049160.86534996
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86504002
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86036162
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.85647715
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84766228
67AMPK signaling pathway_Homo sapiens_hsa041520.84188598
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83434413
69Pancreatic secretion_Homo sapiens_hsa049720.81174755
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.80271624
71Endometrial cancer_Homo sapiens_hsa052130.79573648
72Insulin signaling pathway_Homo sapiens_hsa049100.79000667
73Choline metabolism in cancer_Homo sapiens_hsa052310.78875557
74Ovarian steroidogenesis_Homo sapiens_hsa049130.78841669
75Glioma_Homo sapiens_hsa052140.78383834
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78161961
77ECM-receptor interaction_Homo sapiens_hsa045120.77492794
78Protein digestion and absorption_Homo sapiens_hsa049740.77300128
79Focal adhesion_Homo sapiens_hsa045100.76702586
80Vitamin B6 metabolism_Homo sapiens_hsa007500.76673213
81Insulin resistance_Homo sapiens_hsa049310.75184065
82MAPK signaling pathway_Homo sapiens_hsa040100.73868514
83MicroRNAs in cancer_Homo sapiens_hsa052060.71545503
84Butanoate metabolism_Homo sapiens_hsa006500.70468160
85Hippo signaling pathway_Homo sapiens_hsa043900.69777569
86Small cell lung cancer_Homo sapiens_hsa052220.69253241
87Chronic myeloid leukemia_Homo sapiens_hsa052200.68568114
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67929855
89PPAR signaling pathway_Homo sapiens_hsa033200.64541135
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63823328
91Prion diseases_Homo sapiens_hsa050200.63072646
92Phenylalanine metabolism_Homo sapiens_hsa003600.62860470
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62719350
94Thyroid hormone synthesis_Homo sapiens_hsa049180.62558133
95Bile secretion_Homo sapiens_hsa049760.62421011
96Ras signaling pathway_Homo sapiens_hsa040140.62082957
97Non-small cell lung cancer_Homo sapiens_hsa052230.61418908
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61345747
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.61024850
100Lysine degradation_Homo sapiens_hsa003100.60953538
101mTOR signaling pathway_Homo sapiens_hsa041500.60021471
102Inositol phosphate metabolism_Homo sapiens_hsa005620.59894096
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59708991
104Fatty acid elongation_Homo sapiens_hsa000620.58290480
105Arginine and proline metabolism_Homo sapiens_hsa003300.56877002
106Ether lipid metabolism_Homo sapiens_hsa005650.55092963
107Amoebiasis_Homo sapiens_hsa051460.53864655
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53826485
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.53645877
110Endocytosis_Homo sapiens_hsa041440.53377365
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52555753
112VEGF signaling pathway_Homo sapiens_hsa043700.51533979
113Fatty acid degradation_Homo sapiens_hsa000710.51518223
114Proteoglycans in cancer_Homo sapiens_hsa052050.50510203
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49906330
116Nitrogen metabolism_Homo sapiens_hsa009100.49309673
117Circadian rhythm_Homo sapiens_hsa047100.49104690
118Collecting duct acid secretion_Homo sapiens_hsa049660.47403856
119Hedgehog signaling pathway_Homo sapiens_hsa043400.47287588
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46054648
121Rap1 signaling pathway_Homo sapiens_hsa040150.45380023
122Glycerolipid metabolism_Homo sapiens_hsa005610.45195580
123Oocyte meiosis_Homo sapiens_hsa041140.44373458

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