MICALCL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.55001232
2epithelial cilium movement (GO:0003351)9.35511737
3plasma membrane fusion (GO:0045026)9.31154674
4cilium or flagellum-dependent cell motility (GO:0001539)9.25036500
5cell-cell recognition (GO:0009988)9.19936059
6binding of sperm to zona pellucida (GO:0007339)9.12355808
7reproduction (GO:0000003)8.78065976
8motile cilium assembly (GO:0044458)8.71475486
9spermatid development (GO:0007286)8.62656698
10regulation of cilium movement (GO:0003352)8.25630899
11cilium movement (GO:0003341)7.80527446
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.52362142
13sperm capacitation (GO:0048240)7.23182429
14single fertilization (GO:0007338)6.90308232
15hemidesmosome assembly (GO:0031581)6.66573971
16piRNA metabolic process (GO:0034587)6.45571282
17male meiosis (GO:0007140)6.42313164
18organic cation transport (GO:0015695)6.21306956
19negative regulation of inclusion body assembly (GO:0090084)6.13741018
20synaptonemal complex organization (GO:0070193)6.09783537
21* spermatogenesis (GO:0007283)5.87034325
22* male gamete generation (GO:0048232)5.84275120
23fertilization (GO:0009566)5.73812226
24synaptonemal complex assembly (GO:0007130)5.73228737
25microtubule depolymerization (GO:0007019)5.62186932
26* gamete generation (GO:0007276)5.37294046
27regulation of inclusion body assembly (GO:0090083)5.20349663
28calcium ion-dependent exocytosis (GO:0017156)5.16882834
29establishment of skin barrier (GO:0061436)4.97654952
30regulation of microtubule-based movement (GO:0060632)4.94961100
31ventricular system development (GO:0021591)4.83773679
32cellular process involved in reproduction in multicellular organism (GO:0022412)4.76259401
33germ cell development (GO:0007281)4.73492319
34regulation of water loss via skin (GO:0033561)4.47498607
35cell recognition (GO:0008037)4.45151047
36glycerol ether metabolic process (GO:0006662)4.43356559
37left/right pattern formation (GO:0060972)4.39329815
38regulation of DNA methylation (GO:0044030)4.36986265
39spermatid nucleus differentiation (GO:0007289)4.31503949
40* multicellular organismal reproductive process (GO:0048609)4.25047937
41ether metabolic process (GO:0018904)4.13928030
42male meiosis I (GO:0007141)4.07906755
43microtubule severing (GO:0051013)4.04233485
44DNA methylation involved in gamete generation (GO:0043046)3.97893219
45desmosome organization (GO:0002934)3.95738380
46regulation of female gonad development (GO:2000194)3.92400851
47keratinization (GO:0031424)3.82926044
48modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.80891625
49positive regulation by organism of defense response of other organism involved in symbiotic interact3.80891625
50modulation by symbiont of host immune response (GO:0052553)3.80891625
51positive regulation by symbiont of host defense response (GO:0052509)3.80891625
52modulation by symbiont of host defense response (GO:0052031)3.80891625
53modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.80891625
54chromosome organization involved in meiosis (GO:0070192)3.74589857
55sexual reproduction (GO:0019953)3.68151539
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.62555311
57neutrophil activation involved in immune response (GO:0002283)3.56048073
58seminiferous tubule development (GO:0072520)3.55425306
59detection of other organism (GO:0098543)3.54117517
60chromosome condensation (GO:0030261)3.53633882
61keratinocyte proliferation (GO:0043616)3.53538331
62glycine transport (GO:0015816)3.51049474
63histone H3-K9 demethylation (GO:0033169)3.47990446
64meiotic nuclear division (GO:0007126)3.47923193
65* multicellular organismal development (GO:0007275)3.46300565
66DNA packaging (GO:0006323)3.44182540
67sequestering of actin monomers (GO:0042989)3.43172787
68macrophage activation involved in immune response (GO:0002281)3.43031456
69response to peptidoglycan (GO:0032494)3.41841179
70genitalia morphogenesis (GO:0035112)3.40494910
71chaperone-mediated protein complex assembly (GO:0051131)3.37837644
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33392289
73protein localization to cilium (GO:0061512)3.31114564
74alditol metabolic process (GO:0019400)3.28535956
75single strand break repair (GO:0000012)3.27245308
76histone H3-K36 demethylation (GO:0070544)3.27207655
77polyol catabolic process (GO:0046174)3.26477241
78carnitine transport (GO:0015879)3.26025920
79amino-acid betaine transport (GO:0015838)3.26025920
80axoneme assembly (GO:0035082)3.24442796
81regulation of meiosis I (GO:0060631)3.23749361
82oocyte development (GO:0048599)3.19762270
83detection of molecule of bacterial origin (GO:0032490)3.16258576
84erythrocyte development (GO:0048821)3.15742795
85meiosis I (GO:0007127)3.14903750
86detection of bacterium (GO:0016045)3.11615124
87hypotonic response (GO:0006971)3.11311681
88cellular extravasation (GO:0045123)3.11030270
89carnitine transmembrane transport (GO:1902603)3.10431055
90regulation of interferon-beta biosynthetic process (GO:0045357)3.10172530
91protein polyglutamylation (GO:0018095)3.10134755
92hormone catabolic process (GO:0042447)3.06672429
93interferon-gamma secretion (GO:0072643)3.05875603
94retrograde transport, vesicle recycling within Golgi (GO:0000301)3.05644657
95cell-substrate junction assembly (GO:0007044)3.05480480
96lactate metabolic process (GO:0006089)3.04418576
97protein targeting to Golgi (GO:0000042)3.03280222
98glycerol metabolic process (GO:0006071)3.01820458
99negative regulation of histone methylation (GO:0031061)3.00005309
100positive regulation of Cdc42 GTPase activity (GO:0043089)2.98688824
101response to muramyl dipeptide (GO:0032495)2.95789405
102detection of external biotic stimulus (GO:0098581)2.95088411
103regulation of T-helper 2 cell differentiation (GO:0045628)2.93434880
104negative regulation of cAMP-mediated signaling (GO:0043951)2.92744376
105histone lysine demethylation (GO:0070076)2.92051970
106cilium morphogenesis (GO:0060271)2.90847512
107cellular glucuronidation (GO:0052695)2.88772688
108cilium organization (GO:0044782)2.87747498
109glycolytic process (GO:0006096)2.87283961
110neutrophil mediated immunity (GO:0002446)2.85117115
111intraciliary transport (GO:0042073)2.84181287
112protein K11-linked deubiquitination (GO:0035871)2.84014016
113positive regulation of gamma-delta T cell activation (GO:0046645)2.82824313
114histone demethylation (GO:0016577)2.82561094
115regulation of cell maturation (GO:1903429)2.81709607
116cilium assembly (GO:0042384)2.80865808
117establishment of protein localization to Golgi (GO:0072600)2.80376240
118surfactant homeostasis (GO:0043129)2.78018657
119regulation of mast cell degranulation (GO:0043304)2.77890953
120bundle of His cell to Purkinje myocyte communication (GO:0086069)2.74672937
121fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.72585368
122cellular response to arsenic-containing substance (GO:0071243)2.72489031
123negative regulation of execution phase of apoptosis (GO:1900118)2.69407527
124multicellular organismal water homeostasis (GO:0050891)2.68324336
125microglial cell activation (GO:0001774)2.68016713
126glucuronate metabolic process (GO:0019585)2.66622985
127uronic acid metabolic process (GO:0006063)2.66622985
128regulation of mast cell activation involved in immune response (GO:0033006)2.66452308
129regulation of acrosome reaction (GO:0060046)2.66424237
130myeloid cell activation involved in immune response (GO:0002275)2.65494981
131regulation of histone H3-K9 methylation (GO:0051570)2.65390513
132peptide cross-linking (GO:0018149)2.65210738
133protein refolding (GO:0042026)2.64762685
134lipoxygenase pathway (GO:0019372)2.64501790
135regulation of RNA export from nucleus (GO:0046831)2.62155947
136macrophage activation (GO:0042116)2.61943432
137cellular component assembly involved in morphogenesis (GO:0010927)2.61526597
138neutrophil activation (GO:0042119)2.60495301
139positive regulation of humoral immune response (GO:0002922)2.60007898
140centriole assembly (GO:0098534)2.59969240
141positive regulation of glycolytic process (GO:0045821)2.58386884
142keratinocyte differentiation (GO:0030216)2.58345206
143granulocyte activation (GO:0036230)2.56046474
144detection of biotic stimulus (GO:0009595)2.55895801
145N-terminal protein amino acid acetylation (GO:0006474)2.55174850
146regulation of leukocyte degranulation (GO:0043300)2.54198542
147phosphatidylethanolamine biosynthetic process (GO:0006646)2.53572885
148monoubiquitinated protein deubiquitination (GO:0035520)2.52945136
149protein kinase C signaling (GO:0070528)2.52520544
150meiotic cell cycle (GO:0051321)2.50607081
151microtubule-based movement (GO:0007018)2.50157652
152microtubule polymerization or depolymerization (GO:0031109)2.48853131
153myeloid cell development (GO:0061515)2.47303980
154protein demethylation (GO:0006482)2.47067971
155protein dealkylation (GO:0008214)2.47067971
156nucleoside diphosphate phosphorylation (GO:0006165)2.45791139
157regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.45513725
158water homeostasis (GO:0030104)2.44956498
159centriole replication (GO:0007099)2.44695928
160fructose metabolic process (GO:0006000)2.44300430
161phosphatidylethanolamine metabolic process (GO:0046337)2.43426470
162negative regulation of T cell mediated immunity (GO:0002710)2.42275771
163cellular carbohydrate catabolic process (GO:0044275)2.42265953
164regulation of myeloid leukocyte mediated immunity (GO:0002886)2.41799628
165hepatocyte apoptotic process (GO:0097284)2.41695810
166negative regulation of interleukin-12 production (GO:0032695)2.41440084
167peptidyl-glutamic acid modification (GO:0018200)2.41115493
168sulfate transmembrane transport (GO:1902358)2.40926089
169regulation of gamma-delta T cell activation (GO:0046643)2.40196816
170interleukin-6-mediated signaling pathway (GO:0070102)2.39582667
171early endosome to late endosome transport (GO:0045022)2.39202504
172negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.38992965
173negative regulation of cell killing (GO:0031342)2.38992965
174response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.38835190
175response to host (GO:0075136)2.38835190
176response to host defenses (GO:0052200)2.38835190
177response to host immune response (GO:0052572)2.38498836
178response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.38498836
179iron ion import (GO:0097286)2.38344934
180positive regulation of macrophage activation (GO:0043032)2.37752205
181positive regulation of cellular amide metabolic process (GO:0034250)2.36761712
182oxygen transport (GO:0015671)2.36567353
183protein localization to endosome (GO:0036010)2.36382033
184polyol transport (GO:0015791)2.36315464
185polyamine biosynthetic process (GO:0006596)2.36279198
186RNA localization (GO:0006403)2.35359830
187calcium ion import (GO:0070509)2.34146663
188sperm motility (GO:0030317)12.6212828
189fusion of sperm to egg plasma membrane (GO:0007342)12.3563197
190cell wall macromolecule metabolic process (GO:0044036)12.2380951
191cell wall macromolecule catabolic process (GO:0016998)12.2380951
192acrosome reaction (GO:0007340)10.9095146
193acrosome assembly (GO:0001675)10.5709435
194sperm-egg recognition (GO:0035036)10.2817923
195multicellular organism reproduction (GO:0032504)10.2375581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.82412949
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.76964578
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.91492020
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.31001831
5EZH2_22144423_ChIP-Seq_EOC_Human3.25355508
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.21466479
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.89885440
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.86152445
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.62245851
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.62110270
11GATA1_19941826_ChIP-Seq_K562_Human2.60622664
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.57196105
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51947334
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45543815
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.41574716
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37353550
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34429880
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.31339906
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27765548
20VDR_22108803_ChIP-Seq_LS180_Human2.26962446
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.26667304
22* FOXO3_23340844_ChIP-Seq_DLD1_Human2.07372342
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.97273724
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94112349
25RUNX_20019798_ChIP-Seq_JUKART_Human1.94080719
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.93316708
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92477795
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.91251983
29GATA2_19941826_ChIP-Seq_K562_Human1.90858551
30SCL_19346495_ChIP-Seq_HPC-7_Human1.87360014
31VDR_24787735_ChIP-Seq_THP-1_Human1.84331908
32GATA1_22025678_ChIP-Seq_K562_Human1.81484389
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.80792885
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.80792885
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79380444
36SOX9_24532713_ChIP-Seq_HFSC_Mouse1.76249160
37TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.74089004
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73304061
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.71254306
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.70341427
41VDR_24763502_ChIP-Seq_THP-1_Human1.68244274
42SPI1_23127762_ChIP-Seq_K562_Human1.67172298
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.67124331
44KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.65101183
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.63821004
46TCF7_22412390_ChIP-Seq_EML_Mouse1.63280495
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.62682627
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61753443
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61500886
50TP63_23658742_ChIP-Seq_EP156T_Human1.60045607
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58725378
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.58169078
53KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.58027127
54MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.56621864
55ELK4_26923725_Chip-Seq_MESODERM_Mouse1.55823956
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.54835699
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54532744
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54183198
59STAT1_17558387_ChIP-Seq_HELA_Human1.53663829
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52512279
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50628732
62TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.50546096
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.50240538
64ZNF274_21170338_ChIP-Seq_K562_Hela1.50158139
65* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.49037271
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45402990
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.45253974
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43989966
69CBP_20019798_ChIP-Seq_JUKART_Human1.43989966
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39706091
71KDM2B_26808549_Chip-Seq_REH_Human1.39697131
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39011044
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38928410
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35163514
75GATA1_19941827_ChIP-Seq_MEL86_Mouse1.34184542
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34091664
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33584491
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32072978
79KAP1_22055183_ChIP-Seq_ESCs_Mouse1.31891957
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28173951
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.27649989
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27094638
83WDR5_24793694_ChIP-Seq_LNCAP_Human1.26960769
84SOX2_22085726_ChIP-Seq_NPCs_Mouse1.26914769
85GATA3_21867929_ChIP-Seq_CD8_Mouse1.26890171
86GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.26242653
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.25945285
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.25668015
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.25494591
90REST_21632747_ChIP-Seq_MESCs_Mouse1.24807767
91FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24668342
92AHR_22903824_ChIP-Seq_MCF-7_Human1.24668172
93TAF15_26573619_Chip-Seq_HEK293_Human1.23378907
94MYB_26560356_Chip-Seq_TH2_Human1.22444383
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22423341
96GF1_26923725_Chip-Seq_HPCs_Mouse1.22363032
97MYB_26560356_Chip-Seq_TH1_Human1.21472422
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21026504
99* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20923951
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19422543
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18778132
102* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18183308
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17954958
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17936891
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.16815849
106P53_22387025_ChIP-Seq_ESCs_Mouse1.16371561
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.15308085
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.14104737
109KLF5_25053715_ChIP-Seq_YYC3_Human1.13496413
110SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13374395
111RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13293533
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13281314
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13077909
114P53_21459846_ChIP-Seq_SAOS-2_Human1.12585715
115RNF2_27304074_Chip-Seq_NSC_Mouse1.12514326
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12314473
117KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11598427
118* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11145764
119CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10862643
120LXR_22158963_ChIP-Seq_LIVER_Mouse1.10744264
121LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.10137307
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10071423
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09879835
124OCT4_18555785_Chip-Seq_ESCs_Mouse1.09862001
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09382618
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09382618
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09284639
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09215387
129RUNX1_22412390_ChIP-Seq_EML_Mouse1.08957850
130EZH2_27294783_Chip-Seq_NPCs_Mouse1.08679268
131GATA3_21867929_ChIP-Seq_TH1_Mouse1.07926109
132CMYC_18555785_Chip-Seq_ESCs_Mouse1.07716982
133* ATF3_27146783_Chip-Seq_COLON_Human1.06147098
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05562411
135P300_18555785_Chip-Seq_ESCs_Mouse1.05238670
136NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04766712
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04667643
138PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03954801
139SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.03210841
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03112679
141EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03009558
142SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02483651
143CJUN_26792858_Chip-Seq_BT549_Human1.02154318
144ELK3_25401928_ChIP-Seq_HUVEC_Human1.02007203
145ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00926519
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00699198
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00664138
148KLF4_18555785_Chip-Seq_ESCs_Mouse1.00420133
149GF1B_26923725_Chip-Seq_HPCs_Mouse1.00122679
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99777443
151TP53_16413492_ChIP-PET_HCT116_Human0.99722970
152MAF_26560356_Chip-Seq_TH1_Human0.99486790
153NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98906403
154PU1_27457419_Chip-Seq_LIVER_Mouse0.98724639
155SMRT_27268052_Chip-Seq_Bcells_Human0.98423716
156FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98164904
157OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97958942
158ERG_20517297_ChIP-Seq_VCAP_Human0.97340872
159MYC_27129775_Chip-Seq_CORNEA_Mouse0.96882372
160EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96837969
161KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96836914
162RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96364109
163SOX2_18555785_Chip-Seq_ESCs_Mouse0.96086580
164SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96024381
165RUNX1_27514584_Chip-Seq_MCF-7_Human0.95696018
166TP63_22573176_ChIP-Seq_HFKS_Human0.95598448
167EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95313957
168KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95118376
169ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94466132
170GATA3_27048872_Chip-Seq_THYMUS_Human0.94413638
171ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94408443
172SMAD4_21799915_ChIP-Seq_A2780_Human0.94404303
173NCOR1_26117541_ChIP-Seq_K562_Human0.94276554
174STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93098881
175EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91861330
176KDM2B_26808549_Chip-Seq_DND41_Human0.91470416
177STAT3_18555785_Chip-Seq_ESCs_Mouse0.91454133
178TCF4_18268006_ChIP-ChIP_LS174T_Human0.91263892
179ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90632046
180E2F1_18555785_Chip-Seq_ESCs_Mouse0.90329878
181KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90173796
182KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90173796
183KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90173796
184UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90144979
185VDR_21846776_ChIP-Seq_THP-1_Human0.89929397
186* UBF1/2_26484160_Chip-Seq_HMECs_Human0.89784954
187LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89079963
188SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88755826
189RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88373613
190NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88312690
191GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88312256
192RARA_24833708_ChIP-Seq_LIVER_Mouse0.88205287
193CTCF_18555785_Chip-Seq_ESCs_Mouse0.87619687
194FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86482094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.13980272
2MP0001929_abnormal_gametogenesis4.46066859
3MP0001984_abnormal_olfaction3.56533578
4MP0003656_abnormal_erythrocyte_physiolo3.56074480
5MP0008877_abnormal_DNA_methylation3.25140049
6MP0008260_abnormal_autophagy3.06042824
7MP0002161_abnormal_fertility/fecundity2.72732864
8MP0003718_maternal_effect2.65802417
9MP0002210_abnormal_sex_determination2.65611816
10MP0003453_abnormal_keratinocyte_physiol2.53882873
11MP0004947_skin_inflammation2.51631830
12MP0005451_abnormal_body_composition2.50787374
13MP0002653_abnormal_ependyma_morphology2.50432192
14MP0005670_abnormal_white_adipose2.48567779
15MP0003878_abnormal_ear_physiology2.47528274
16MP0005377_hearing/vestibular/ear_phenot2.47528274
17MP0004381_abnormal_hair_follicle2.45143871
18MP0008875_abnormal_xenobiotic_pharmacok2.40082804
19MP0003191_abnormal_cellular_cholesterol2.28406258
20MP0001145_abnormal_male_reproductive2.20402462
21MP0010678_abnormal_skin_adnexa2.16436898
22MP0005501_abnormal_skin_physiology2.16188579
23MP0003566_abnormal_cell_adhesion2.09217550
24MP0003303_peritoneal_inflammation2.07224596
25MP0005409_darkened_coat_color2.04809292
26MP0002139_abnormal_hepatobiliary_system2.00096382
27MP0005410_abnormal_fertilization14.2412025
28MP0005499_abnormal_olfactory_system1.98365945
29MP0005394_taste/olfaction_phenotype1.98365945
30MP0003436_decreased_susceptibility_to1.98192878
31MP0000653_abnormal_sex_gland1.96101859
32MP0001216_abnormal_epidermal_layer1.93362658
33MP0003724_increased_susceptibility_to1.92884507
34MP0002060_abnormal_skin_morphology1.91854543
35MP0008789_abnormal_olfactory_epithelium1.80319632
36MP0005360_urolithiasis1.71439974
37MP0005397_hematopoietic_system_phenotyp1.70529331
38MP0001545_abnormal_hematopoietic_system1.70529331
39MP0005085_abnormal_gallbladder_physiolo1.59299982
40MP0005076_abnormal_cell_differentiation1.55332704
41MP0002234_abnormal_pharynx_morphology1.55144728
42MP0002419_abnormal_innate_immunity1.54532271
43MP0003828_pulmonary_edema1.54384705
44MP0003091_abnormal_cell_migration1.52699811
45MP0005365_abnormal_bile_salt1.50921648
46MP0005083_abnormal_biliary_tract1.50515202
47MP0002160_abnormal_reproductive_system1.48900074
48MP0005023_abnormal_wound_healing1.47922597
49MP0010234_abnormal_vibrissa_follicle1.45243578
50MP0008004_abnormal_stomach_pH1.45054222
51MP0002138_abnormal_hepatobiliary_system1.43777710
52MP0003950_abnormal_plasma_membrane1.40825627
53MP0005310_abnormal_salivary_gland1.38089670
54MP0000377_abnormal_hair_follicle1.37539878
55MP0000685_abnormal_immune_system1.37446029
56MP0000383_abnormal_hair_follicle1.37026248
57MP0003300_gastrointestinal_ulcer1.35696905
58MP0000015_abnormal_ear_pigmentation1.35342854
59MP0001765_abnormal_ion_homeostasis1.31385219
60MP0005395_other_phenotype1.28843008
61MP0010771_integument_phenotype1.28247348
62MP0005164_abnormal_response_to1.26364503
63MP0005647_abnormal_sex_gland1.24652411
64MP0005025_abnormal_response_to1.24116792
65MP0010352_gastrointestinal_tract_polyps1.22958700
66MP0009840_abnormal_foam_cell1.18219126
67MP0001851_eye_inflammation1.18070218
68MP0005464_abnormal_platelet_physiology1.17082888
69MP0009931_abnormal_skin_appearance1.16724305
70MP0004043_abnormal_pH_regulation1.16049272
71MP0009785_altered_susceptibility_to1.15529593
72MP0001835_abnormal_antigen_presentation1.14289879
73MP0006082_CNS_inflammation1.13378183
74MP0002452_abnormal_antigen_presenting1.10105023
75MP0000427_abnormal_hair_cycle1.09321049
76MP0001666_abnormal_nutrient_absorption1.05997041
77MP0005000_abnormal_immune_tolerance1.05629120
78MP0009278_abnormal_bone_marrow1.05407321
79MP0002420_abnormal_adaptive_immunity1.04993197
80MP0004782_abnormal_surfactant_physiolog1.04986775
81MP0004019_abnormal_vitamin_homeostasis1.03932739
82MP0008057_abnormal_DNA_replication1.03840366
83MP0010307_abnormal_tumor_latency1.03452417
84MP0001800_abnormal_humoral_immune1.03277112
85MP0001819_abnormal_immune_cell1.02726778
86MP0010329_abnormal_lipoprotein_level1.02225187
87MP0000678_abnormal_parathyroid_gland1.02220855
88MP0002006_tumorigenesis1.01685402
89MP0002723_abnormal_immune_serum1.01473994
90MP0003806_abnormal_nucleotide_metabolis1.01005697
91MP0000465_gastrointestinal_hemorrhage1.00198563
92MP0002405_respiratory_system_inflammati0.99947764
93MP0003252_abnormal_bile_duct0.99171429
94MP0003045_fibrosis0.97205190
95MP0000858_altered_metastatic_potential0.96931864
96MP0001790_abnormal_immune_system0.94339905
97MP0005387_immune_system_phenotype0.94339905
98MP0004883_abnormal_blood_vessel0.93066480
99MP0003941_abnormal_skin_development0.89711345
100MP0003172_abnormal_lysosome_physiology0.89473843
101MP0002396_abnormal_hematopoietic_system0.88981055
102MP0002282_abnormal_trachea_morphology0.88223076
103MP0005389_reproductive_system_phenotype0.86482810
104MP0002398_abnormal_bone_marrow0.86172681
105MP0002998_abnormal_bone_remodeling0.83419986
106MP0001533_abnormal_skeleton_physiology0.82120710
107MP0005636_abnormal_mineral_homeostasis0.82034341
108MP0002166_altered_tumor_susceptibility0.81467861
109MP0003448_altered_tumor_morphology0.81177462
110MP0005621_abnormal_cell_physiology0.80930105
111MP0002148_abnormal_hypersensitivity_rea0.79764882
112MP0005623_abnormal_meninges_morphology0.79462650
113MP0002254_reproductive_system_inflammat0.77790927
114MP0003763_abnormal_thymus_physiology0.76779978
115MP0002796_impaired_skin_barrier0.74600071
116MP0000462_abnormal_digestive_system0.72592367
117MP0004134_abnormal_chest_morphology0.71424487
118MP0003115_abnormal_respiratory_system0.66372295
119MP0001324_abnormal_eye_pigmentation0.64263383
120MP0005551_abnormal_eye_electrophysiolog0.64251376
121MP0001764_abnormal_homeostasis0.63020179
122MP0000579_abnormal_nail_morphology0.62156191
123MP0002233_abnormal_nose_morphology0.61782905
124MP0008995_early_reproductive_senescence0.61502882
125MP0002118_abnormal_lipid_homeostasis0.61376451
126MP0005187_abnormal_penis_morphology0.60843493
127MP0002132_abnormal_respiratory_system0.58571433
128MP0000647_abnormal_sebaceous_gland0.58555327
129MP0009115_abnormal_fat_cell0.56319847
130MP0001270_distended_abdomen0.55270319
131MP0005646_abnormal_pituitary_gland0.55206057
132MP0002009_preneoplasia0.53533139
133MP0005275_abnormal_skin_tensile0.53146008
134MP0004233_abnormal_muscle_weight0.53017037
135MP0002971_abnormal_brown_adipose0.51194357
136MP0004264_abnormal_extraembryonic_tissu0.50445383
137MP0003183_abnormal_peptide_metabolism0.49406295
138MP0005332_abnormal_amino_acid0.49048837
139MP0003329_amyloid_beta_deposits0.48757878
140MP0002928_abnormal_bile_duct0.48043833
141MP0008961_abnormal_basal_metabolism0.45344436
142MP0003646_muscle_fatigue0.43918504
143MP0003879_abnormal_hair_cell0.43286187
144MP0003705_abnormal_hypodermis_morpholog0.42371596
145MP0000566_synostosis0.41949957
146MP0001849_ear_inflammation0.41570626
147MP0009046_muscle_twitch0.41276170
148MP0002098_abnormal_vibrissa_morphology0.40508998
149MP0009250_abnormal_appendicular_skeleto0.40160694
150MP0002909_abnormal_adrenal_gland0.39936642
151MP0000534_abnormal_ureter_morphology0.39466258
152MP0002295_abnormal_pulmonary_circulatio0.39422665
153MP0005257_abnormal_intraocular_pressure0.38806278
154MP0004885_abnormal_endolymph0.37809085
155MP0001919_abnormal_reproductive_system0.37217617
156MP0009780_abnormal_chondrocyte_physiolo0.36063426
157MP0003942_abnormal_urinary_system0.35398287
158MP0000467_abnormal_esophagus_morphology0.34769367
159MP0003699_abnormal_female_reproductive0.34544244
160MP0005666_abnormal_adipose_tissue0.34186034
161MP0000049_abnormal_middle_ear0.34094792
162MP0001944_abnormal_pancreas_morphology0.33279786
163MP0005253_abnormal_eye_physiology0.33026903
164MP0003868_abnormal_feces_composition0.32473179
165MP0003633_abnormal_nervous_system0.32174979
166MP0001502_abnormal_circadian_rhythm0.31892488
167MP0002557_abnormal_social/conspecific_i0.30865664
168MP0000569_abnormal_digit_pigmentation0.29730627
169MP0005319_abnormal_enzyme/_coenzyme0.29575181
170MP0001293_anophthalmia0.29372336
171MP0003953_abnormal_hormone_level0.29318974
172MP0009643_abnormal_urine_homeostasis0.28592917
173MP0000762_abnormal_tongue_morphology0.28406162
174MP0009053_abnormal_anal_canal0.28374822
175MP0003195_calcinosis0.27507692
176MP0002822_catalepsy0.27204487

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.96162733
2Abnormal respiratory epithelium morphology (HP:0012253)8.53551850
3Abnormal respiratory motile cilium morphology (HP:0005938)8.53551850
4Chronic bronchitis (HP:0004469)7.19139403
5Abnormal ciliary motility (HP:0012262)7.07336915
6Rhinitis (HP:0012384)7.03863726
7Infertility (HP:0000789)6.10127871
8Milia (HP:0001056)5.85321156
9Nasal polyposis (HP:0100582)5.52736981
10Abnormality of nail color (HP:0100643)5.42072692
11Thick nail (HP:0001805)4.98032120
12Plantar hyperkeratosis (HP:0007556)4.60100146
13Abnormality of the nasal mucosa (HP:0000433)4.38588693
14Male infertility (HP:0003251)4.29328933
15Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.26399315
16Bronchiectasis (HP:0002110)4.21484076
17Bronchitis (HP:0012387)4.15870554
18Lip pit (HP:0100267)4.00948414
19Fragile nails (HP:0001808)3.92572228
20Tubulointerstitial nephritis (HP:0001970)3.79690119
21Nephronophthisis (HP:0000090)3.79199521
22Alopecia of scalp (HP:0002293)3.71469405
23Palmoplantar hyperkeratosis (HP:0000972)3.67901547
24Recurrent bacterial skin infections (HP:0005406)3.52827257
25Eczematoid dermatitis (HP:0000976)3.45168851
26Palmar hyperkeratosis (HP:0010765)3.42037289
27Abnormal spermatogenesis (HP:0008669)3.37868293
28Atrophic scars (HP:0001075)3.36143837
29Abnormality of the renal medulla (HP:0100957)3.29121435
30Abnormal blistering of the skin (HP:0008066)3.27202905
31Increased IgE level (HP:0003212)3.19185400
32Abnormality of macrophages (HP:0004311)2.98607252
33Recurrent otitis media (HP:0000403)2.93775601
34Nail dystrophy (HP:0008404)2.92598474
35Recurrent sinusitis (HP:0011108)2.88081094
36Medial flaring of the eyebrow (HP:0010747)2.87914060
37Recurrent abscess formation (HP:0002722)2.86574498
38Papillary thyroid carcinoma (HP:0002895)2.76827892
39Pustule (HP:0200039)2.76494227
40Tubulointerstitial abnormality (HP:0001969)2.76284576
41Tubular atrophy (HP:0000092)2.71410375
42Osteomalacia (HP:0002749)2.59328333
43Impulsivity (HP:0100710)2.56031351
44Erythema (HP:0010783)2.53058105
45Gingivitis (HP:0000230)2.52454590
46Pili torti (HP:0003777)2.51569472
47Hypochromic microcytic anemia (HP:0004840)2.50290812
48Poikilocytosis (HP:0004447)2.44789062
49Abnormality of midbrain morphology (HP:0002418)2.40833556
50Molar tooth sign on MRI (HP:0002419)2.40833556
51Periodontitis (HP:0000704)2.37840824
52Gastrointestinal infarctions (HP:0005244)2.37666028
53Abnormal gallbladder physiology (HP:0012438)2.36575089
54Cholecystitis (HP:0001082)2.36575089
55Orchitis (HP:0100796)2.36261605
56Myositis (HP:0100614)2.34112791
57Abnormality of the heme biosynthetic pathway (HP:0010472)2.32479496
58Abnormality of the salivary glands (HP:0010286)2.32303543
59Azoospermia (HP:0000027)2.29904130
60Subacute progressive viral hepatitis (HP:0006572)2.27130257
61Corneal erosion (HP:0200020)2.26246120
62Hypotrichosis (HP:0001006)2.25997262
63Ridged nail (HP:0001807)2.25198912
64Retrobulbar optic neuritis (HP:0100654)2.25100783
65Optic neuritis (HP:0100653)2.25100783
66Urticaria (HP:0001025)2.21977856
67Keratoconjunctivitis sicca (HP:0001097)2.21550367
68Congenital ichthyosiform erythroderma (HP:0007431)2.20505694
69Tubulointerstitial fibrosis (HP:0005576)2.15668009
70Severe visual impairment (HP:0001141)2.15055676
71Recurrent bronchitis (HP:0002837)2.13691321
72Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.13053532
73Sparse scalp hair (HP:0002209)2.11221433
74Ectropion (HP:0000656)2.10129499
75Abnormality of the renal cortex (HP:0011035)2.09895811
76Anhidrosis (HP:0000970)2.08657909
77Gonadotropin excess (HP:0000837)2.07449554
78Abnormality of the fingertips (HP:0001211)2.03683004
79Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.03486475
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03358071
81Cone-rod dystrophy (HP:0000548)2.02894939
82Oral leukoplakia (HP:0002745)2.00828653
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8281248
84Dynein arm defect of respiratory motile cilia (HP:0012255)12.5106984
85Absent/shortened dynein arms (HP:0200106)12.5106984
86Cheilitis (HP:0100825)1.97956873
87Slow saccadic eye movements (HP:0000514)1.97611044
88Stomatitis (HP:0010280)1.96894434
89Gingival bleeding (HP:0000225)1.96343066
90Hypercholesterolemia (HP:0003124)1.95903313
91Osteomyelitis (HP:0002754)1.95756706
92Recurrent skin infections (HP:0001581)1.94764263
93Microcytic anemia (HP:0001935)1.94167592
94Congenital hepatic fibrosis (HP:0002612)1.93682279
95Keratoconjunctivitis (HP:0001096)1.92427241
96Flat acetabular roof (HP:0003180)1.90819929
97Dyschromatopsia (HP:0007641)1.89573363
98Resting tremor (HP:0002322)1.88034882
99Skin ulcer (HP:0200042)1.87428711
100Renal dysplasia (HP:0000110)1.86672189
101Abnormal biliary tract physiology (HP:0012439)1.85874192
102Bile duct proliferation (HP:0001408)1.85874192
103Abnormality of secondary sexual hair (HP:0009888)1.85428282
104Abnormality of the axillary hair (HP:0100134)1.85428282
105Decreased central vision (HP:0007663)1.85423609
106Polycythemia (HP:0001901)1.84857604
107Ankyloglossia (HP:0010296)1.83580394
108Spastic tetraparesis (HP:0001285)1.83577525
109Potter facies (HP:0002009)1.82934582
110Facial shape deformation (HP:0011334)1.82934582
111Truncal obesity (HP:0001956)1.82764361
112Amyloidosis (HP:0011034)1.82532354
113Interstitial pulmonary disease (HP:0006530)1.82516726
114Chronic hepatic failure (HP:0100626)1.82446298
115Gangrene (HP:0100758)1.82050744
116Cholelithiasis (HP:0001081)1.81465759
117Hypoplastic labia majora (HP:0000059)1.80843208
118Abnormal hair laboratory examination (HP:0003328)1.80332907
119Stage 5 chronic kidney disease (HP:0003774)1.79055787
120Choroideremia (HP:0001139)1.78706096
121Congenital primary aphakia (HP:0007707)1.78159969
122Postaxial foot polydactyly (HP:0001830)1.78084422
123Bell-shaped thorax (HP:0001591)1.77068677
124Pruritus (HP:0000989)1.76048955
125Abnormality of renal excretion (HP:0011036)1.75490266
126Gait imbalance (HP:0002141)1.75462384
127Blepharitis (HP:0000498)1.74717211
128Aplasia/Hypoplasia of the lens (HP:0008063)1.72785832
129Amelogenesis imperfecta (HP:0000705)1.72654059
130Hemorrhage of the eye (HP:0011885)1.68748736
131Postural instability (HP:0002172)1.68276618
132Dehydration (HP:0001944)1.67836696
133Peritonitis (HP:0002586)1.67263026
134Loss of speech (HP:0002371)1.66557289
135Neurofibrillary tangles (HP:0002185)1.66549069
136Hypochromic anemia (HP:0001931)1.66035053
137Abnormality of the labia majora (HP:0012881)1.65999834
138Hypophosphatemic rickets (HP:0004912)1.62404625
139Recurrent gram-negative bacterial infections (HP:0005420)1.62324160
140Spontaneous hematomas (HP:0007420)1.61900018
141Median cleft lip (HP:0000161)1.60845861
142Osteolytic defects of the hand bones (HP:0009699)1.60595188
143Osteolytic defects of the phalanges of the hand (HP:0009771)1.60595188
144Glucose intolerance (HP:0000833)1.60097862
145Postaxial hand polydactyly (HP:0001162)1.60043321
146Prolonged bleeding time (HP:0003010)1.59404355
147Hypohidrosis (HP:0000966)1.58363112
148Cystic liver disease (HP:0006706)1.58318959
149Abnormality of dentin (HP:0010299)1.57842928
150Abnormality of permanent molar morphology (HP:0011071)1.53397044
151Abnormality of the dental root (HP:0006486)1.53397044
152Taurodontia (HP:0000679)1.53397044
153Nephrogenic diabetes insipidus (HP:0009806)1.52353959
154Right ventricular cardiomyopathy (HP:0011663)1.51728958
155Onycholysis (HP:0001806)1.51708833
156Short ribs (HP:0000773)1.51551147
157Retinal atrophy (HP:0001105)1.49499483
158Retinal dysplasia (HP:0007973)1.49327299
159Pancreatic fibrosis (HP:0100732)1.49202920
160Abnormality of molar (HP:0011077)1.48624640
161Abnormality of molar morphology (HP:0011070)1.48624640
162Abnormality of the dental pulp (HP:0006479)1.48451093
163Abnormal glucose tolerance (HP:0001952)1.47745005
164Malnutrition (HP:0004395)1.47382874
165Polydipsia (HP:0001959)1.47190711
166Abnormal drinking behavior (HP:0030082)1.47190711
167Hyperkalemia (HP:0002153)1.46961986
168Hypoplasia of dental enamel (HP:0006297)1.45112714
169Vascular calcification (HP:0004934)1.44150575
170Facial cleft (HP:0002006)1.43391006
171Abnormality of the neuromuscular junction (HP:0003398)1.42825487
172Fatigable weakness (HP:0003473)1.42825487
173Decreased electroretinogram (ERG) amplitude (HP:0000654)1.40426755
174Hemiparesis (HP:0001269)1.40347411
175Congenital malformation of the right heart (HP:0011723)1.40192230
176Double outlet right ventricle (HP:0001719)1.40192230
177Bundle branch block (HP:0011710)1.38870266
178Vaginal atresia (HP:0000148)1.38596546
179Absent eyebrow (HP:0002223)1.36247686
180Nephropathy (HP:0000112)1.35368450
181Poor coordination (HP:0002370)1.35314200
182Genital tract atresia (HP:0001827)1.35087731
183Abnormal urine output (HP:0012590)1.33461032
184True hermaphroditism (HP:0010459)1.31588129
185Cerebral inclusion bodies (HP:0100314)1.31325957
186Oculomotor apraxia (HP:0000657)1.30858017
187Cardiovascular calcification (HP:0011915)1.29788367
188Asymmetric septal hypertrophy (HP:0001670)1.26891058
189Heterotopia (HP:0002282)1.26743205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.58080349
2PDK47.58080349
3TESK16.29920416
4PRKD35.32539477
5PDK24.79805360
6ICK4.01990483
7MAP3K133.58779771
8ARAF3.30039154
9MAP3K93.19182363
10CDK122.78005076
11KSR22.72383210
12STK242.36108111
13PRPF4B2.31548022
14MAP2K32.11467209
15WNK41.97089705
16TAOK31.92746412
17PTK2B1.92306001
18NEK11.79748432
19STK381.76788124
20MET1.74212492
21DYRK1B1.63606403
22MAPK151.60075803
23MOS1.58553628
24RAF11.49173665
25CSK1.46967272
26STK391.46727257
27PIK3CG1.41546765
28CAMK1D1.41225629
29BLK1.41208069
30NEK21.40164375
31IRAK41.36075921
32TRPM71.35874995
33KSR11.34393882
34IKBKE1.32623948
35LMTK21.27933527
36ZAP701.27466104
37JAK31.24825007
38BMPR21.24015238
39ERBB31.23185790
40MAP3K141.22857047
41GRK61.20839428
42EIF2AK11.20837605
43IRAK11.18326783
44PIM11.14056982
45MAP3K61.13588300
46TAOK21.08283722
47IRAK31.07636999
48FGR1.01772705
49PNCK0.99071218
50FRK0.98130895
51MAP3K110.92959661
52BRD40.91664013
53MAP3K80.91336744
54PDK10.90828932
55CHUK0.90167688
56TYK20.89063012
57IKBKB0.86671448
58CDK90.85046692
59TGFBR20.84523516
60RIPK40.82037559
61WNK10.81759358
62MATK0.75234664
63PDPK10.71667411
64MAP3K50.71295552
65JAK20.68815797
66STK38L0.67933654
67MAP3K30.66654137
68SIK10.66521228
69INSRR0.64937622
70MAP2K60.62396334
71LRRK20.62314319
72PTK20.62300434
73NTRK20.62063339
74MAP3K20.61527377
75HCK0.59372894
76TYRO30.58380415
77RIPK10.57955445
78TBK10.56259067
79RET0.55577989
80MELK0.54730927
81AKT30.53582585
82PRKAA20.52078227
83TNK20.51950079
84PRKCI0.50777966
85STK40.49739486
86MAP4K10.49737581
87RPS6KA20.49667314
88BMPR1B0.49602032
89JAK10.49202148
90MST40.48785900
91FGFR30.48592014
92DYRK30.47384107
93IRAK20.46755527
94STK30.46692015
95FER0.46340222
96MST1R0.45932157
97SYK0.45415344
98PLK40.44864795
99PRKG20.42641571
100PRKCG0.42608622
101BMX0.42375830
102MAP2K10.39987790
103CSF1R0.39886197
104MUSK0.39704276
105TTK0.38492260
106MAPKAPK20.38362684
107STK100.38334540
108CDK70.37901027
109TNIK0.37689778
110NEK90.37651816
111CAMK1G0.35921988
112EPHB20.35785587
113MARK20.34124734
114LATS10.33624480
115SGK20.33384204
116TAOK10.31121462
117CASK0.30584556
118PASK0.30365013
119ERN10.30236659
120CHEK20.28591065
121PAK30.27272514
122PRKCZ0.26985422
123NEK60.26241208
124MAP3K10.25049787
125MARK30.23864279
126PINK10.22836014
127CDK30.22335562
128YES10.21142446
129MAP3K40.20877373
130SGK30.20407462
131CLK10.20320339
132CAMK2G0.20038093
133EPHB10.19947761
134TRIB30.19124598
135CAMK2D0.18465594
136SGK2230.18215524
137SGK4940.18215524
138PAK10.18038234
139EPHA20.17493144
140PBK0.16789360
141CAMK2A0.16703431
142GRK10.16650631
143ERBB40.14461545
144PRKAA10.14367556
145PIK3CA0.14143134
146RPS6KB10.13340686
147PRKCA0.12815757
148EPHA30.12482725
149CCNB10.11839331
150PRKCQ0.11610762
151DAPK20.10449693
152BRAF0.10014513
153PRKG10.09985246
154ATM0.09724766
155MTOR0.09686207
156WNK30.08939981
157PRKCE0.08904930
158PTK60.08309510
159GSK3A0.08275832
160PAK20.07210934
161CAMKK10.06706016
162CHEK10.06345453
163MAP2K70.06145907

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.50615203
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.29259333
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.86404500
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.78613746
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.71679348
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.65402889
7Sulfur metabolism_Homo sapiens_hsa009202.61314807
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.44178415
9Pyruvate metabolism_Homo sapiens_hsa006202.39509482
10Chemical carcinogenesis_Homo sapiens_hsa052042.34928037
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.25983037
12Mineral absorption_Homo sapiens_hsa049782.21973843
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16371256
14Propanoate metabolism_Homo sapiens_hsa006402.12553983
15PPAR signaling pathway_Homo sapiens_hsa033202.02479569
16Fatty acid degradation_Homo sapiens_hsa000712.01207359
17Fat digestion and absorption_Homo sapiens_hsa049751.99990513
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.95371823
19Linoleic acid metabolism_Homo sapiens_hsa005911.91614426
20Osteoclast differentiation_Homo sapiens_hsa043801.84952722
21Acute myeloid leukemia_Homo sapiens_hsa052211.83828592
22Non-small cell lung cancer_Homo sapiens_hsa052231.80330312
23Vitamin B6 metabolism_Homo sapiens_hsa007501.79754760
24Glucagon signaling pathway_Homo sapiens_hsa049221.73908649
25Malaria_Homo sapiens_hsa051441.70024668
26B cell receptor signaling pathway_Homo sapiens_hsa046621.67803672
27Fatty acid metabolism_Homo sapiens_hsa012121.67153552
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63743289
29Renal cell carcinoma_Homo sapiens_hsa052111.61260264
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60706656
31Pancreatic cancer_Homo sapiens_hsa052121.60589651
32Leishmaniasis_Homo sapiens_hsa051401.59602005
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.56279211
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.56183112
35Retinol metabolism_Homo sapiens_hsa008301.56097590
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52790466
37Thyroid cancer_Homo sapiens_hsa052161.50803777
38Selenocompound metabolism_Homo sapiens_hsa004501.47964280
39Toxoplasmosis_Homo sapiens_hsa051451.47822371
40Starch and sucrose metabolism_Homo sapiens_hsa005001.47519170
41Glycerolipid metabolism_Homo sapiens_hsa005611.46702572
42Chronic myeloid leukemia_Homo sapiens_hsa052201.45511402
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45371952
44Bile secretion_Homo sapiens_hsa049761.43789804
45Influenza A_Homo sapiens_hsa051641.42022850
46Small cell lung cancer_Homo sapiens_hsa052221.41278601
47Fructose and mannose metabolism_Homo sapiens_hsa000511.39591011
48Glutathione metabolism_Homo sapiens_hsa004801.37467514
49Amoebiasis_Homo sapiens_hsa051461.34879470
50VEGF signaling pathway_Homo sapiens_hsa043701.33991159
51Endometrial cancer_Homo sapiens_hsa052131.33278143
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32909561
53Tuberculosis_Homo sapiens_hsa051521.31901897
54TNF signaling pathway_Homo sapiens_hsa046681.30410787
55FoxO signaling pathway_Homo sapiens_hsa040681.25856390
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25178515
57ErbB signaling pathway_Homo sapiens_hsa040121.23607983
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22476080
59T cell receptor signaling pathway_Homo sapiens_hsa046601.20850075
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20807649
61Jak-STAT signaling pathway_Homo sapiens_hsa046301.19617374
62Hepatitis B_Homo sapiens_hsa051611.17434089
63Collecting duct acid secretion_Homo sapiens_hsa049661.17389514
64Measles_Homo sapiens_hsa051621.16851982
65Notch signaling pathway_Homo sapiens_hsa043301.14997280
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14577708
67Chemokine signaling pathway_Homo sapiens_hsa040621.13660660
68Sulfur relay system_Homo sapiens_hsa041221.13573035
69Pentose phosphate pathway_Homo sapiens_hsa000301.13139425
70NF-kappa B signaling pathway_Homo sapiens_hsa040641.12226493
71Glycerophospholipid metabolism_Homo sapiens_hsa005641.12087146
72ABC transporters_Homo sapiens_hsa020101.11658123
73Maturity onset diabetes of the young_Homo sapiens_hsa049501.10043726
74Adherens junction_Homo sapiens_hsa045201.09277495
75mTOR signaling pathway_Homo sapiens_hsa041501.09144368
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07181692
77Prolactin signaling pathway_Homo sapiens_hsa049171.06444214
78Legionellosis_Homo sapiens_hsa051341.06030680
79Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05794862
80Neurotrophin signaling pathway_Homo sapiens_hsa047221.05033836
81Glycosaminoglycan degradation_Homo sapiens_hsa005311.04676378
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02571644
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02240674
84Prostate cancer_Homo sapiens_hsa052151.01685685
85Primary bile acid biosynthesis_Homo sapiens_hsa001201.01343193
86Bladder cancer_Homo sapiens_hsa052191.00712452
87Amphetamine addiction_Homo sapiens_hsa050311.00402200
88Hematopoietic cell lineage_Homo sapiens_hsa046401.00317985
89HIF-1 signaling pathway_Homo sapiens_hsa040660.99379882
90Insulin secretion_Homo sapiens_hsa049110.99135173
91Hepatitis C_Homo sapiens_hsa051600.99057052
92Apoptosis_Homo sapiens_hsa042100.98686068
93Peroxisome_Homo sapiens_hsa041460.97233032
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.96303327
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95030944
96Carbon metabolism_Homo sapiens_hsa012000.94234466
97Galactose metabolism_Homo sapiens_hsa000520.93690234
98MicroRNAs in cancer_Homo sapiens_hsa052060.93622332
99Circadian rhythm_Homo sapiens_hsa047100.92559563
100Platelet activation_Homo sapiens_hsa046110.88873081
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.88713917
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.87845143
103Choline metabolism in cancer_Homo sapiens_hsa052310.85971892
104Phagosome_Homo sapiens_hsa041450.85931125
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85785050
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85377838
107Focal adhesion_Homo sapiens_hsa045100.84956222
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84409901
109Dorso-ventral axis formation_Homo sapiens_hsa043200.84401456
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84091045
111GnRH signaling pathway_Homo sapiens_hsa049120.84066732
112Olfactory transduction_Homo sapiens_hsa047400.83766379
113p53 signaling pathway_Homo sapiens_hsa041150.83733779
114Vitamin digestion and absorption_Homo sapiens_hsa049770.83720335
115Ether lipid metabolism_Homo sapiens_hsa005650.83651116
116Renin secretion_Homo sapiens_hsa049240.83450781
117Endocytosis_Homo sapiens_hsa041440.83309443
118Herpes simplex infection_Homo sapiens_hsa051680.83182285
119Proteoglycans in cancer_Homo sapiens_hsa052050.81816102
120Shigellosis_Homo sapiens_hsa051310.80445205
121ECM-receptor interaction_Homo sapiens_hsa045120.79875909
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79873991
123Glioma_Homo sapiens_hsa052140.78778588
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77890599
125Staphylococcus aureus infection_Homo sapiens_hsa051500.75566112
126Renin-angiotensin system_Homo sapiens_hsa046140.75133391
127African trypanosomiasis_Homo sapiens_hsa051430.74640513
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73935588
129Insulin resistance_Homo sapiens_hsa049310.73310876
130Gastric acid secretion_Homo sapiens_hsa049710.73229979
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.72536162
132Thyroid hormone synthesis_Homo sapiens_hsa049180.71733629
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71036418
134Viral carcinogenesis_Homo sapiens_hsa052030.70640752
135Ovarian steroidogenesis_Homo sapiens_hsa049130.70434593
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.69794434
137Cell cycle_Homo sapiens_hsa041100.69152338
138Histidine metabolism_Homo sapiens_hsa003400.68112393
139Basal transcription factors_Homo sapiens_hsa030220.65162433
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65161292
141Pertussis_Homo sapiens_hsa051330.64326150
142Butanoate metabolism_Homo sapiens_hsa006500.62697150
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62240549
144Salmonella infection_Homo sapiens_hsa051320.62171018
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61540135
146Type II diabetes mellitus_Homo sapiens_hsa049300.61267438
147Phenylalanine metabolism_Homo sapiens_hsa003600.61160988
148Insulin signaling pathway_Homo sapiens_hsa049100.60932318
149Pancreatic secretion_Homo sapiens_hsa049720.60295918
150MAPK signaling pathway_Homo sapiens_hsa040100.57894094
151Protein digestion and absorption_Homo sapiens_hsa049740.57891307
152Arachidonic acid metabolism_Homo sapiens_hsa005900.57202535
153Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55879211
154Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55205001
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.55087251
156Cardiac muscle contraction_Homo sapiens_hsa042600.54856211
157Synaptic vesicle cycle_Homo sapiens_hsa047210.54611727
158Pathways in cancer_Homo sapiens_hsa052000.54427875
159Central carbon metabolism in cancer_Homo sapiens_hsa052300.53309244
160Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51258914
161Salivary secretion_Homo sapiens_hsa049700.50048254
162beta-Alanine metabolism_Homo sapiens_hsa004100.47410744
163Tryptophan metabolism_Homo sapiens_hsa003800.46373993
164Nitrogen metabolism_Homo sapiens_hsa009100.45770004
165Taste transduction_Homo sapiens_hsa047420.44982696
166Metabolic pathways_Homo sapiens_hsa011000.43460013
167Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41803314
168Vibrio cholerae infection_Homo sapiens_hsa051100.39552327
169Steroid biosynthesis_Homo sapiens_hsa001000.37801509
170cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37703107
171Huntingtons disease_Homo sapiens_hsa050160.36848600
172Complement and coagulation cascades_Homo sapiens_hsa046100.35979196
173Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35134249
174cAMP signaling pathway_Homo sapiens_hsa040240.34301459
175Biosynthesis of amino acids_Homo sapiens_hsa012300.33205148
176Circadian entrainment_Homo sapiens_hsa047130.31984610
177Estrogen signaling pathway_Homo sapiens_hsa049150.30788881
178Calcium signaling pathway_Homo sapiens_hsa040200.30349405
179Purine metabolism_Homo sapiens_hsa002300.28495831
180Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28337265
181Long-term potentiation_Homo sapiens_hsa047200.27407192
182Sphingolipid metabolism_Homo sapiens_hsa006000.26173522
183Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25834795
184Cocaine addiction_Homo sapiens_hsa050300.23975694
185Tyrosine metabolism_Homo sapiens_hsa003500.23794814
186Oocyte meiosis_Homo sapiens_hsa041140.23790253
187Inositol phosphate metabolism_Homo sapiens_hsa005620.22496140

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