MICALL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.57642996
2central nervous system myelination (GO:0022010)4.57642996
3dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.39750414
4cell adhesion mediated by integrin (GO:0033627)4.33642339
5regulation of water loss via skin (GO:0033561)4.20600262
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.19497047
7regulation of vitamin D biosynthetic process (GO:0060556)4.08594717
8skin morphogenesis (GO:0043589)4.07629560
9establishment of skin barrier (GO:0061436)4.04241005
10endodermal cell differentiation (GO:0035987)4.03742721
11keratinocyte proliferation (GO:0043616)4.01691255
12negative regulation of potassium ion transmembrane transport (GO:1901380)3.90779822
13creatine metabolic process (GO:0006600)3.85137584
14planar cell polarity pathway involved in neural tube closure (GO:0090179)3.71624684
15sarcomere organization (GO:0045214)3.70954513
16cardiac myofibril assembly (GO:0055003)3.61398140
17regulation of early endosome to late endosome transport (GO:2000641)3.59417037
18positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.58826905
19plasma membrane repair (GO:0001778)3.55805021
20regulation of hair follicle development (GO:0051797)3.49693736
21cytoskeletal anchoring at plasma membrane (GO:0007016)3.48140795
22ensheathment of neurons (GO:0007272)3.43233785
23axon ensheathment (GO:0008366)3.43233785
24regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.40805467
25epithelial cell differentiation involved in prostate gland development (GO:0060742)3.38452355
26adherens junction assembly (GO:0034333)3.37279204
27epithelial cell-cell adhesion (GO:0090136)3.36989442
28myelination (GO:0042552)3.36303613
29positive regulation of hair follicle development (GO:0051798)3.35975183
30positive regulation of hair cycle (GO:0042635)3.35975183
31myelin maintenance (GO:0043217)3.35915531
32regulation of apoptotic process involved in morphogenesis (GO:1902337)3.33847624
33hemidesmosome assembly (GO:0031581)3.33694043
34positive regulation of epidermis development (GO:0045684)3.28975559
35negative regulation of keratinocyte proliferation (GO:0010839)3.28303715
36focal adhesion assembly (GO:0048041)3.24998616
37cell-substrate adherens junction assembly (GO:0007045)3.24998616
38myofibril assembly (GO:0030239)3.22138824
39vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.19146056
40regulation of membrane protein ectodomain proteolysis (GO:0051043)3.18148676
41regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.16752528
42negative regulation of protein localization to cell surface (GO:2000009)3.15489704
43adhesion of symbiont to host cell (GO:0044650)3.14204712
44virion attachment to host cell (GO:0019062)3.14204712
45activation of MAPKKK activity (GO:0000185)3.09713842
46peptidyl-tyrosine autophosphorylation (GO:0038083)3.06352412
47basement membrane organization (GO:0071711)3.03900799
48substrate-dependent cell migration (GO:0006929)3.02706955
49keratinization (GO:0031424)3.02317776
50heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.01058494
51regulation of vitamin metabolic process (GO:0030656)3.00699360
52apoptotic process involved in morphogenesis (GO:0060561)2.99134323
53regulation of integrin activation (GO:0033623)2.93977986
54barbed-end actin filament capping (GO:0051016)2.93280952
55wound healing, spreading of epidermal cells (GO:0035313)2.91968531
56polarized epithelial cell differentiation (GO:0030859)2.90050347
57* protein localization to endosome (GO:0036010)2.88992247
58negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.88517347
59positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.87920422
60positive regulation of keratinocyte differentiation (GO:0045618)2.86279131
61ventricular cardiac muscle cell action potential (GO:0086005)2.86097071
62actomyosin structure organization (GO:0031032)2.84147838
63surfactant homeostasis (GO:0043129)2.83835801
64cell communication involved in cardiac conduction (GO:0086065)2.83761368
65decidualization (GO:0046697)2.83622375
66myelination in peripheral nervous system (GO:0022011)2.83607194
67peripheral nervous system axon ensheathment (GO:0032292)2.83607194
68positive regulation of blood vessel endothelial cell migration (GO:0043536)2.81322392
69atrioventricular valve morphogenesis (GO:0003181)2.81320060
70gap junction assembly (GO:0016264)2.80591182
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80048897
72regulation of NFAT protein import into nucleus (GO:0051532)2.78191612
73bundle of His cell to Purkinje myocyte communication (GO:0086069)2.77288432
74asymmetric protein localization (GO:0008105)2.76877120
75mesodermal cell differentiation (GO:0048333)2.76141102
76vascular endothelial growth factor signaling pathway (GO:0038084)2.76001969
77nerve growth factor signaling pathway (GO:0038180)2.74511276
78regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.73292830
79hypotonic response (GO:0006971)2.70044356
80glial cell migration (GO:0008347)2.69519084
81branching involved in mammary gland duct morphogenesis (GO:0060444)2.68068650
82extracellular matrix disassembly (GO:0022617)2.68047331
83establishment of tissue polarity (GO:0007164)2.66049249
84establishment of planar polarity (GO:0001736)2.66049249
85regulation of actin filament-based movement (GO:1903115)2.65971937
86regulation of podosome assembly (GO:0071801)2.65442650
87cellular copper ion homeostasis (GO:0006878)2.65399149
88positive regulation of epidermal cell differentiation (GO:0045606)2.65253997
89sodium ion export (GO:0071436)2.64953606
90regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64535355
91endothelial cell chemotaxis (GO:0035767)2.64475731
92negative regulation of chondrocyte differentiation (GO:0032331)2.63580294
93actin-myosin filament sliding (GO:0033275)2.63229652
94muscle filament sliding (GO:0030049)2.63229652
95adhesion of symbiont to host (GO:0044406)2.63120730
96activation of Rac GTPase activity (GO:0032863)2.62378733
97regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.61095045
98cardiac muscle contraction (GO:0060048)2.60545604
99cell communication by electrical coupling (GO:0010644)2.60296043
100keratinocyte differentiation (GO:0030216)2.58969186
101wound healing, spreading of cells (GO:0044319)2.57706874
102collagen metabolic process (GO:0032963)2.57704596
103modulation by symbiont of host cellular process (GO:0044068)2.56621052
104low-density lipoprotein particle clearance (GO:0034383)2.56198349
105cellular response to epinephrine stimulus (GO:0071872)2.55654467
106stress fiber assembly (GO:0043149)2.54666437
107collagen catabolic process (GO:0030574)2.54611630
108positive regulation of Cdc42 GTPase activity (GO:0043089)2.54202440
109Golgi transport vesicle coating (GO:0048200)2.53646899
110COPI coating of Golgi vesicle (GO:0048205)2.53646899
111cell junction assembly (GO:0034329)2.53099163
112apical protein localization (GO:0045176)2.52968195
113cortical actin cytoskeleton organization (GO:0030866)2.52695663
114trophoblast giant cell differentiation (GO:0060707)2.51464992
115mammary gland epithelial cell proliferation (GO:0033598)2.50567211
116regulation of p38MAPK cascade (GO:1900744)2.49255676
117semaphorin-plexin signaling pathway (GO:0071526)2.48040804
118cell-substrate junction assembly (GO:0007044)2.46820292
119intermediate filament organization (GO:0045109)2.46632493
120cell junction organization (GO:0034330)2.45406439
121pinocytosis (GO:0006907)2.43322334
122establishment of nucleus localization (GO:0040023)2.42246698
123negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.42188845
124positive regulation of p38MAPK cascade (GO:1900745)2.42015308
125growth hormone receptor signaling pathway (GO:0060396)2.41765821
126serine transport (GO:0032329)2.41545809
127Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.40966508
128lipopolysaccharide-mediated signaling pathway (GO:0031663)2.40944962
129negative regulation of erythrocyte differentiation (GO:0045647)2.40641978
130response to laminar fluid shear stress (GO:0034616)2.40378344
131potassium ion import (GO:0010107)2.39832855
132heart trabecula formation (GO:0060347)2.39679530
133axon extension involved in axon guidance (GO:0048846)2.39592885
134neuron projection extension involved in neuron projection guidance (GO:1902284)2.39592885
135response to progesterone (GO:0032570)2.39426936
136lymph vessel development (GO:0001945)2.39352023
137cellular response to catecholamine stimulus (GO:0071870)2.39037147
138cellular response to monoamine stimulus (GO:0071868)2.39037147
139ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.38956740
140negative regulation of fatty acid transport (GO:2000192)2.38707361
141establishment of apical/basal cell polarity (GO:0035089)2.37246015
142adult heart development (GO:0007512)2.37133895
143regulation of membrane repolarization (GO:0060306)2.37040305
144regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.36889268
145regulation of cardioblast differentiation (GO:0051890)2.35631403
146carnitine shuttle (GO:0006853)2.35304243
147protein targeting to plasma membrane (GO:0072661)2.34702844
148positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.33447084
149* membrane tubulation (GO:0097320)2.33176307
150renal filtration (GO:0097205)2.31705667
151astrocyte development (GO:0014002)2.30520968
152response to epinephrine (GO:0071871)2.30500594
153fatty acid elongation (GO:0030497)2.30067608
154cardiac muscle tissue morphogenesis (GO:0055008)2.29441089
155neuromuscular junction development (GO:0007528)2.29272562
156cardiac muscle cell development (GO:0055013)2.28922863
157actin-mediated cell contraction (GO:0070252)2.27749820
158regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.26906179
159regulation of ARF GTPase activity (GO:0032312)2.26453746
160regulation of skeletal muscle contraction (GO:0014819)2.25759107
161regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.22618771
162regulation of cardiac muscle cell contraction (GO:0086004)2.22145298
163photoreceptor cell differentiation (GO:0046530)2.22023785
164eye photoreceptor cell differentiation (GO:0001754)2.22023785
165desmosome organization (GO:0002934)2.21699548
166response to catecholamine (GO:0071869)2.21467246
167response to monoamine (GO:0071867)2.21467246
168cellular response to growth hormone stimulus (GO:0071378)2.21416919
169response to nerve growth factor (GO:1990089)2.20644877
170cellular response to nerve growth factor stimulus (GO:1990090)2.20644877
171cortical cytoskeleton organization (GO:0030865)2.19520990
172cardiac cell development (GO:0055006)2.18127827
173actin filament-based movement (GO:0030048)2.18072738
174negative regulation of neurotransmitter secretion (GO:0046929)2.17866427
175response to lipoprotein particle (GO:0055094)2.17761481
176membrane raft organization (GO:0031579)2.17379821
177regulation of striated muscle contraction (GO:0006942)2.14550916
178positive regulation of potassium ion transport (GO:0043268)2.11576101
179muscle tissue morphogenesis (GO:0060415)2.10728621
180regulation of relaxation of muscle (GO:1901077)2.09741293
181camera-type eye morphogenesis (GO:0048593)2.09244397
182establishment of mitochondrion localization (GO:0051654)2.09097715
183negative regulation of potassium ion transport (GO:0043267)2.08867756
184negative regulation of cytosolic calcium ion concentration (GO:0051481)2.08649025
185regulation of cell communication by electrical coupling (GO:0010649)2.08502700
186regulation of heart rate by cardiac conduction (GO:0086091)2.08013642
187dendrite morphogenesis (GO:0048813)2.07608137
188regulation of the force of heart contraction (GO:0002026)2.07418219
189glomerular filtration (GO:0003094)2.07255195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73994572
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.61722711
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15558933
4EP300_21415370_ChIP-Seq_HL-1_Mouse2.08843633
5DROSHA_22980978_ChIP-Seq_HELA_Human2.07619385
6TRIM28_21343339_ChIP-Seq_HEK293_Human1.97106930
7VDR_21846776_ChIP-Seq_THP-1_Human1.95779226
8ESR2_21235772_ChIP-Seq_MCF-7_Human1.89511673
9* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.87139094
10* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.87139094
11UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.83871043
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83650478
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83063530
14KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.80837716
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.78517597
16* UBF1/2_26484160_Chip-Seq_HMECs_Human1.76468346
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74754177
18EGR1_19374776_ChIP-ChIP_THP-1_Human1.74682505
19* ATF3_27146783_Chip-Seq_COLON_Human1.69015679
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67406746
21TBX20_22328084_ChIP-Seq_HEART_Mouse1.67362862
22TBX20_22080862_ChIP-Seq_HEART_Mouse1.67362862
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66702186
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66702186
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63847374
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62437585
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.61772201
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61244628
29* TP53_22127205_ChIP-Seq_IMR90_Human1.60216598
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60019791
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59722461
32* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59600670
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55628836
34KDM2B_26808549_Chip-Seq_K562_Human1.53478970
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53068491
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52808404
37* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52477650
38TCF7_22412390_ChIP-Seq_EML_Mouse1.51590133
39MYC_22102868_ChIP-Seq_BL_Human1.51077875
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50980845
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48641073
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48501001
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44906766
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.44534981
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42993003
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42325855
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41461599
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39484551
49AR_21572438_ChIP-Seq_LNCaP_Human1.38058142
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.37659050
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37196981
52EZH2_22144423_ChIP-Seq_EOC_Human1.36522546
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.35433691
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34818868
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34698346
56KDM2B_26808549_Chip-Seq_DND41_Human1.34105515
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.33909273
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.30564202
59* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29342715
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28714406
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28292783
62AHR_22903824_ChIP-Seq_MCF-7_Human1.27411562
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26585069
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26423636
65CLOCK_20551151_ChIP-Seq_293T_Human1.25753114
66* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25008537
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.24375910
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.24344987
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23187343
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22921614
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21254319
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.19084286
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18519041
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16878130
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16697889
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13972742
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13907091
78VDR_24763502_ChIP-Seq_THP-1_Human1.13291277
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12108681
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11676892
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11558413
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09737481
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.09362986
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.09338607
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08817007
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08148747
87FOXA2_19822575_ChIP-Seq_HepG2_Human1.07602404
88CJUN_26792858_Chip-Seq_BT549_Human1.07234955
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06405968
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.06043719
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05878039
92* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04745995
93* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04582216
94RACK7_27058665_Chip-Seq_MCF-7_Human1.03567140
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03435581
96* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03306857
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03102369
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02908289
99LXR_22292898_ChIP-Seq_THP-1_Human1.02475225
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.02413640
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02171081
102* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01355363
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01142622
104ELK3_25401928_ChIP-Seq_HUVEC_Human1.01052587
105ZNF263_19887448_ChIP-Seq_K562_Human1.00756961
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00540423
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00516812
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00268185
109GATA1_19941826_ChIP-Seq_K562_Human0.99855562
110ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99615914
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99041151
112TP53_16413492_ChIP-PET_HCT116_Human0.98801032
113* SMC4_20622854_ChIP-Seq_HELA_Human0.98657139
114SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98460881
115EED_16625203_ChIP-ChIP_MESCs_Mouse0.98032568
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97583020
117CREB1_26743006_Chip-Seq_LNCaP_Human0.97543470
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97291663
119* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97276170
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97004863
121RUNX1_27514584_Chip-Seq_MCF-7_Human0.96380110
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95708803
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95708803
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95596671
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95338432
126* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94989193
127P68_20966046_ChIP-Seq_HELA_Human0.94731381
128TP53_23651856_ChIP-Seq_MEFs_Mouse0.94143385
129TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94038817
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93732351
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92718585
132* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92375364
133ISL1_27105846_Chip-Seq_CPCs_Mouse0.92339512
134* KLF5_25053715_ChIP-Seq_YYC3_Human0.91985763
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.91655232
136STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91651113
137TET1_21490601_ChIP-Seq_MESCs_Mouse0.91605370
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90883112
139* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89986044
140KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89497757
141KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89284220
142WT1_19549856_ChIP-ChIP_CCG9911_Human0.89027740
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88760950
144P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88740118
145TP63_22573176_ChIP-Seq_HFKS_Human0.88147559
146RXR_22108803_ChIP-Seq_LS180_Human0.87689192
147BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87539227
148* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85986230
149TP53_20018659_ChIP-ChIP_R1E_Mouse0.85576904
150SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84828430
151SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84507663
152NCOR1_26117541_ChIP-Seq_K562_Human0.83632028
153SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82753180
154POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81954406
155* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80754173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle3.56217111
2MP0000751_myopathy3.38510262
3MP0002837_dystrophic_cardiac_calcinosis3.21782911
4MP0003941_abnormal_skin_development2.78352540
5MP0010234_abnormal_vibrissa_follicle2.69723555
6MP0004036_abnormal_muscle_relaxation2.66899173
7MP0000920_abnormal_myelination2.65438220
8MP0005623_abnormal_meninges_morphology2.61966654
9MP0003950_abnormal_plasma_membrane2.48936530
10MP0005330_cardiomyopathy2.45896321
11MP0005257_abnormal_intraocular_pressure2.27365638
12MP0004087_abnormal_muscle_fiber2.26083194
13MP0008438_abnormal_cutaneous_collagen2.25682252
14MP0005023_abnormal_wound_healing2.24567224
15MP0004215_abnormal_myocardial_fiber2.17893567
16MP0000749_muscle_degeneration2.15165744
17MP0003303_peritoneal_inflammation2.14923852
18MP0001216_abnormal_epidermal_layer2.13878321
19MP0005501_abnormal_skin_physiology2.07326805
20MP0005409_darkened_coat_color1.97887086
21MP0005058_abnormal_lysosome_morphology1.96558834
22MP0002972_abnormal_cardiac_muscle1.96011052
23MP0002254_reproductive_system_inflammat1.95728297
24MP0004272_abnormal_basement_membrane1.93981869
25MP0008775_abnormal_heart_ventricle1.91314272
26MP0004130_abnormal_muscle_cell1.90915315
27MP0009053_abnormal_anal_canal1.88068090
28MP0003705_abnormal_hypodermis_morpholog1.87363148
29MP0000750_abnormal_muscle_regeneration1.85126643
30MP0010678_abnormal_skin_adnexa1.81891337
31MP0009840_abnormal_foam_cell1.80182097
32MP0006138_congestive_heart_failure1.79499303
33MP0005076_abnormal_cell_differentiation1.79343263
34MP0003329_amyloid_beta_deposits1.78242934
35MP0000678_abnormal_parathyroid_gland1.76984324
36MP0010630_abnormal_cardiac_muscle1.76379663
37MP0000747_muscle_weakness1.75706605
38MP0005620_abnormal_muscle_contractility1.74645380
39MP0000383_abnormal_hair_follicle1.73897365
40MP0003690_abnormal_glial_cell1.73769636
41MP0003137_abnormal_impulse_conducting1.73049151
42MP0000733_abnormal_muscle_development1.72354871
43MP0010352_gastrointestinal_tract_polyps1.72244296
44MP0004947_skin_inflammation1.71418319
45MP0004510_myositis1.70723640
46MP0000003_abnormal_adipose_tissue1.69572844
47MP0004185_abnormal_adipocyte_glucose1.68792296
48MP0005275_abnormal_skin_tensile1.67646865
49MP0002098_abnormal_vibrissa_morphology1.64344072
50MP0006054_spinal_hemorrhage1.63572064
51MP0004859_abnormal_synaptic_plasticity1.63522211
52MP0005375_adipose_tissue_phenotype1.55793394
53MP0001348_abnormal_lacrimal_gland1.53660629
54MP0003646_muscle_fatigue1.50924977
55MP0001544_abnormal_cardiovascular_syste1.50109076
56MP0005385_cardiovascular_system_phenoty1.50109076
57MP0002106_abnormal_muscle_physiology1.49659294
58MP0003566_abnormal_cell_adhesion1.49579411
59MP0005666_abnormal_adipose_tissue1.49219063
60MP0003045_fibrosis1.43948580
61MP0000759_abnormal_skeletal_muscle1.42187003
62MP0004233_abnormal_muscle_weight1.41859386
63MP0001299_abnormal_eye_distance/1.41369774
64MP0000858_altered_metastatic_potential1.41010833
65MP0009780_abnormal_chondrocyte_physiolo1.39436603
66MP0010771_integument_phenotype1.38431024
67MP0004085_abnormal_heartbeat1.37617244
68MP0004885_abnormal_endolymph1.36634300
69MP0001346_abnormal_lacrimal_gland1.36235663
70MP0001958_emphysema1.36074002
71MP0003091_abnormal_cell_migration1.35688237
72MP0004484_altered_response_of1.35419784
73MP0000767_abnormal_smooth_muscle1.31573506
74MP0010030_abnormal_orbit_morphology1.29499413
75MP0003279_aneurysm1.28924670
76MP0002234_abnormal_pharynx_morphology1.28546273
77MP0005369_muscle_phenotype1.28311832
78MP0003191_abnormal_cellular_cholesterol1.27022529
79MP0004270_analgesia1.24288955
80MP0003634_abnormal_glial_cell1.23660354
81MP0008260_abnormal_autophagy1.21980251
82MP0004145_abnormal_muscle_electrophysio1.21120823
83MP0000377_abnormal_hair_follicle1.16304098
84MP0003448_altered_tumor_morphology1.14739602
85MP0010368_abnormal_lymphatic_system1.11980687
86MP0002269_muscular_atrophy1.10262005
87MP0005670_abnormal_white_adipose1.09995858
88MP0000013_abnormal_adipose_tissue1.09518341
89MP0003300_gastrointestinal_ulcer1.08596968
90MP0000579_abnormal_nail_morphology1.07973189
91MP0009931_abnormal_skin_appearance1.07493000
92MP0005171_absent_coat_pigmentation1.07271433
93MP0003828_pulmonary_edema1.07149272
94MP0000566_synostosis1.07024509
95MP0002796_impaired_skin_barrier1.05940412
96MP0002896_abnormal_bone_mineralization1.05398782
97MP0004381_abnormal_hair_follicle1.04982258
98MP0008569_lethality_at_weaning1.03513332
99MP0002089_abnormal_postnatal_growth/wei1.03314088
100MP0003221_abnormal_cardiomyocyte_apopto0.99847229
101MP0001915_intracranial_hemorrhage0.99727985
102MP0001243_abnormal_dermal_layer0.97719014
103MP0003453_abnormal_keratinocyte_physiol0.96766954
104MP0002108_abnormal_muscle_morphology0.96447594
105MP0009384_cardiac_valve_regurgitation0.93242986
106MP0003436_decreased_susceptibility_to0.90516616
107MP0004858_abnormal_nervous_system0.89889862
108MP0008961_abnormal_basal_metabolism0.89331506
109MP0005508_abnormal_skeleton_morphology0.86555170
110MP0000778_abnormal_nervous_system0.83446760
111MP0005197_abnormal_uvea_morphology0.82946833
112MP0002998_abnormal_bone_remodeling0.82383591
113MP0001849_ear_inflammation0.82075825
114MP0001191_abnormal_skin_condition0.81938763
115MP0001851_eye_inflammation0.81851174
116MP0001542_abnormal_bone_strength0.81333757
117MP0000604_amyloidosis0.80389811
118MP0002295_abnormal_pulmonary_circulatio0.79690470
119MP0000467_abnormal_esophagus_morphology0.79461491
120MP0005410_abnormal_fertilization0.77157768
121MP0005595_abnormal_vascular_smooth0.76486261
122MP0003632_abnormal_nervous_system0.75636456
123MP0003075_altered_response_to0.74951524
124MP0004742_abnormal_vestibular_system0.74230781
125MP0003172_abnormal_lysosome_physiology0.74007521
126MP0002133_abnormal_respiratory_system0.73742012
127MP0005388_respiratory_system_phenotype0.73742012
128MP0005621_abnormal_cell_physiology0.73495565
129MP0002128_abnormal_blood_circulation0.73394293
130MP0000537_abnormal_urethra_morphology0.73275488
131MP0005451_abnormal_body_composition0.73058247
132MP0005167_abnormal_blood-brain_barrier0.72113015
133MP0000762_abnormal_tongue_morphology0.71869342
134MP0000627_abnormal_mammary_gland0.71334281
135MP0009278_abnormal_bone_marrow0.70971335
136MP0000266_abnormal_heart_morphology0.68815672
137MP0001533_abnormal_skeleton_physiology0.68724463
138MP0003633_abnormal_nervous_system0.68674799
139MP0000534_abnormal_ureter_morphology0.68069168
140MP0000367_abnormal_coat/_hair0.67965912
141MP0005390_skeleton_phenotype0.67323240
142MP0002877_abnormal_melanocyte_morpholog0.67285463
143MP0004264_abnormal_extraembryonic_tissu0.67227723
144MP0001879_abnormal_lymphatic_vessel0.67162228
145MP0003635_abnormal_synaptic_transmissio0.67154483
146MP0003631_nervous_system_phenotype0.66715826
147MP0005193_abnormal_anterior_eye0.66435278
148MP0001486_abnormal_startle_reflex0.66345650
149MP0002060_abnormal_skin_morphology0.66039060
150MP0002148_abnormal_hypersensitivity_rea0.65852390
151MP0000343_altered_response_to0.65413672
152MP0002332_abnormal_exercise_endurance0.64214232
153MP0004782_abnormal_surfactant_physiolog0.60402731
154MP0003755_abnormal_palate_morphology0.58913127
155MP0010307_abnormal_tumor_latency0.58004790
156MP0001614_abnormal_blood_vessel0.56843126
157MP0005164_abnormal_response_to0.56345518
158MP0005165_increased_susceptibility_to0.56270662
159MP0002697_abnormal_eye_size0.56155896
160MP0000432_abnormal_head_morphology0.55705239

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)4.83273937
2Fragile nails (HP:0001808)4.67589956
3Hyporeflexia of lower limbs (HP:0002600)4.63856811
4Muscle fiber splitting (HP:0003555)4.57278665
5Sudden death (HP:0001699)4.48987679
6Plantar hyperkeratosis (HP:0007556)4.34669264
7Difficulty running (HP:0009046)4.01798640
8Alopecia of scalp (HP:0002293)3.81709324
9Right ventricular cardiomyopathy (HP:0011663)3.73595877
10Ventricular tachycardia (HP:0004756)3.58795455
11Nail dystrophy (HP:0008404)3.46773493
12Exercise-induced myalgia (HP:0003738)3.33285081
13Natal tooth (HP:0000695)3.32700150
14Atrial fibrillation (HP:0005110)3.29942156
15Palmoplantar hyperkeratosis (HP:0000972)3.27547460
16Abnormality of the calf musculature (HP:0001430)3.19350466
17Neurofibrillary tangles (HP:0002185)3.12727301
18Calf muscle hypertrophy (HP:0008981)3.08819115
19Increased connective tissue (HP:0009025)3.05477446
20Scapular winging (HP:0003691)3.04554313
21Primary atrial arrhythmia (HP:0001692)3.03917064
22Broad metatarsal (HP:0001783)3.03832694
23Palmar hyperkeratosis (HP:0010765)2.99773054
24Muscle hypertrophy of the lower extremities (HP:0008968)2.93412323
25Selective tooth agenesis (HP:0001592)2.90582113
26Prolonged QT interval (HP:0001657)2.89400610
27Onion bulb formation (HP:0003383)2.88532762
28Ridged nail (HP:0001807)2.84664304
29EMG: myopathic abnormalities (HP:0003458)2.84402562
30Supraventricular arrhythmia (HP:0005115)2.83385835
31Increased variability in muscle fiber diameter (HP:0003557)2.83101875
32Supraventricular tachycardia (HP:0004755)2.81358044
33Ventricular fibrillation (HP:0001663)2.77813296
34Premature rupture of membranes (HP:0001788)2.77771335
35Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.77352100
36Degeneration of the lateral corticospinal tracts (HP:0002314)2.77352100
37Abnormality of the left ventricular outflow tract (HP:0011103)2.73941450
38Subaortic stenosis (HP:0001682)2.73941450
39Bundle branch block (HP:0011710)2.73541796
40Cerebral inclusion bodies (HP:0100314)2.73153017
41Type 1 muscle fiber predominance (HP:0003803)2.70199487
42Abnormal blistering of the skin (HP:0008066)2.69827685
43Exercise-induced muscle cramps (HP:0003710)2.65936163
44Syncope (HP:0001279)2.65524359
45Shallow orbits (HP:0000586)2.64813103
46Lipoatrophy (HP:0100578)2.63757206
47Supranuclear gaze palsy (HP:0000605)2.62808054
48Cervical subluxation (HP:0003308)2.61840140
49Atrophic scars (HP:0001075)2.59891490
50Ventricular arrhythmia (HP:0004308)2.59102368
51Short nail (HP:0001799)2.54478294
52Advanced eruption of teeth (HP:0006288)2.50564992
53Abnormality of glycolipid metabolism (HP:0010969)2.45982981
54Abnormality of liposaccharide metabolism (HP:0010968)2.45982981
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.45982981
56Termporal pattern (HP:0011008)2.40475359
57Insidious onset (HP:0003587)2.40475359
58Abnormality of skeletal muscle fiber size (HP:0012084)2.39774626
59Milia (HP:0001056)2.38011192
60Dilated cardiomyopathy (HP:0001644)2.37267998
61Pterygium (HP:0001059)2.36823819
62Broad face (HP:0000283)2.36102461
63Abnormality of the foot musculature (HP:0001436)2.35049674
64Foot dorsiflexor weakness (HP:0009027)2.33472075
65Thin bony cortex (HP:0002753)2.31552645
66Gowers sign (HP:0003391)2.30814927
67Lower limb amyotrophy (HP:0007210)2.30460921
68Abnormal auditory evoked potentials (HP:0006958)2.29002407
69Difficulty climbing stairs (HP:0003551)2.28397257
70Abnormality of the distal phalanges of the toes (HP:0010182)2.27882277
71Atrioventricular block (HP:0001678)2.27737109
72Vertebral compression fractures (HP:0002953)2.26477752
73Aplasia involving bones of the extremities (HP:0009825)2.26268142
74Aplasia involving bones of the upper limbs (HP:0009823)2.26268142
75Aplasia of the phalanges of the hand (HP:0009802)2.26268142
76Pili torti (HP:0003777)2.25282845
77Trismus (HP:0000211)2.23080372
78Abnormality of the corticospinal tract (HP:0002492)2.22997908
79Genu recurvatum (HP:0002816)2.21517061
80Asymmetric septal hypertrophy (HP:0001670)2.21273232
81Cerebral aneurysm (HP:0004944)2.21038293
82Achilles tendon contracture (HP:0001771)2.19324295
83Hypoplastic ischia (HP:0003175)2.19057497
84Hypoplasia of dental enamel (HP:0006297)2.18967281
85Abnormal atrioventricular conduction (HP:0005150)2.17844317
86Distal lower limb amyotrophy (HP:0008944)2.17484988
87Heart block (HP:0012722)2.17445619
88Ankyloglossia (HP:0010296)2.14183166
89Sparse scalp hair (HP:0002209)2.13886469
90Ankle contracture (HP:0006466)2.13452867
91Distal upper limb amyotrophy (HP:0007149)2.11058577
92Upper limb amyotrophy (HP:0009129)2.11058577
93Axonal loss (HP:0003447)2.07805866
94Hypotrichosis (HP:0001006)2.04418666
95Mildly elevated creatine phosphokinase (HP:0008180)2.02988396
96Round ear (HP:0100830)2.02714696
97Aplasia cutis congenita (HP:0001057)2.01411363
98Sensory axonal neuropathy (HP:0003390)2.01049775
99Follicular hyperkeratosis (HP:0007502)2.00613851
100Myoglobinuria (HP:0002913)1.99008557
101Spinal rigidity (HP:0003306)1.98359887
102Aortic dissection (HP:0002647)1.98015988
103Ankle clonus (HP:0011448)1.97013802
104Macroorchidism (HP:0000053)1.96868515
105Flat acetabular roof (HP:0003180)1.96411356
106Overriding aorta (HP:0002623)1.95584243
107Abnormal hair laboratory examination (HP:0003328)1.95054525
108Lip pit (HP:0100267)1.94502817
109Stridor (HP:0010307)1.93913126
110Distal lower limb muscle weakness (HP:0009053)1.93497224
111Aortic aneurysm (HP:0004942)1.92895806
112Abnormality of oral frenula (HP:0000190)1.92260807
113Blue sclerae (HP:0000592)1.91475564
114Bladder diverticulum (HP:0000015)1.91247917
115Intention tremor (HP:0002080)1.90009987
116Protrusio acetabuli (HP:0003179)1.89514170
117Centrally nucleated skeletal muscle fibers (HP:0003687)1.89406718
118Ulnar bowing (HP:0003031)1.89062819
119Neonatal short-limb short stature (HP:0008921)1.87743034
120Hypoplasia of the iris (HP:0007676)1.87482573
121Abnormality of the salivary glands (HP:0010286)1.86833785
122Abnormality of the ischium (HP:0003174)1.86651088
123Elbow flexion contracture (HP:0002987)1.85717522
124Hyperparathyroidism (HP:0000843)1.85496791
125Premature skin wrinkling (HP:0100678)1.84187414
126Neck muscle weakness (HP:0000467)1.83738540
127Onycholysis (HP:0001806)1.83390326
128Fragile skin (HP:0001030)1.83275004
129Mitral regurgitation (HP:0001653)1.82301979
130Arterial tortuosity (HP:0005116)1.81763816
131Myotonia (HP:0002486)1.81369596
132Sudden cardiac death (HP:0001645)1.81095340
133Absent eyelashes (HP:0000561)1.80709915
134Abnormality of the Achilles tendon (HP:0005109)1.80052747
135Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80043154
136Bell-shaped thorax (HP:0001591)1.79908589
137Loss of speech (HP:0002371)1.78869796
138Hyperacusis (HP:0010780)1.78855760
139Vascular tortuosity (HP:0004948)1.78686722
140Buphthalmos (HP:0000557)1.78455090
141Lymphangioma (HP:0100764)1.78105246
142Anonychia (HP:0001798)1.77995669
143Spastic gait (HP:0002064)1.77909458
144Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.77730076
145Urinary urgency (HP:0000012)1.77656725
146Abnormal EKG (HP:0003115)1.77359138
147Thick nail (HP:0001805)1.75937304
148Nuclear cataract (HP:0100018)1.75850435
149Hamartoma of the eye (HP:0010568)1.75401586
150Wormian bones (HP:0002645)1.75125069
151Rapidly progressive (HP:0003678)1.74915896
152Lower limb muscle weakness (HP:0007340)1.73250660
153Abnormality of the distal phalanx of the thumb (HP:0009617)1.72434553
154Large for gestational age (HP:0001520)1.72434123
155Disproportionate tall stature (HP:0001519)1.71538688
156Osteolytic defects of the hand bones (HP:0009699)1.70927385
157Osteolytic defects of the phalanges of the hand (HP:0009771)1.70927385
158Interstitial pulmonary disease (HP:0006530)1.70357738
159Ectropion (HP:0000656)1.69791575
160Bowing of the arm (HP:0006488)1.67049581
161Bowed forearm bones (HP:0003956)1.67049581
162Abnormal ossification of hand bones (HP:0005921)1.66490211
163Breast hypoplasia (HP:0003187)1.66027717
164Tibial bowing (HP:0002982)1.65761160
165Abnormality of carpal bone ossification (HP:0006257)1.64168436
166Increased cerebral lipofuscin (HP:0011813)1.64018419
167Long palpebral fissure (HP:0000637)1.63752493
168Corneal erosion (HP:0200020)1.63698452
169Popliteal pterygium (HP:0009756)1.61710250
170Dysostosis multiplex (HP:0000943)1.60848410
171Sparse eyelashes (HP:0000653)1.59735913
172Dilatation of the ascending aorta (HP:0005111)1.58290349
173Obstructive sleep apnea (HP:0002870)1.57711267
174Congenital ichthyosiform erythroderma (HP:0007431)1.55177915
175Oral leukoplakia (HP:0002745)1.53833144
176Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.52777339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.54729942
2EPHB13.57325115
3STK393.38467706
4NME23.34574727
5TTN3.24551077
6EPHA23.12583355
7TRIB32.75479702
8SMG12.49927295
9DMPK2.44065363
10MST1R2.24208723
11PRKD32.20009009
12WNK42.02783919
13LMTK21.98528548
14PHKG21.94654243
15PHKG11.94654243
16WNK11.94051314
17CDK121.92983959
18ICK1.90995505
19MAP3K31.85605974
20PAK41.84795532
21PIM21.81745371
22FGFR21.80031920
23PKN21.76714858
24EEF2K1.72288092
25OXSR11.69090328
26PAK61.67038736
27RIPK11.64477148
28PKN11.64321826
29TAOK21.62158393
30MOS1.50848130
31ARAF1.48634310
32PAK31.44142537
33MET1.35284888
34PDGFRA1.32336965
35PRKD11.31278896
36CAMK1G1.30040687
37MAP3K71.29234379
38ROCK21.29073653
39LATS11.28583404
40TYRO31.28006893
41BMX1.27613061
42TGFBR21.25142487
43PTK61.23553484
44SIK11.21573450
45PRPF4B1.19675205
46DDR21.17580139
47MAP3K141.15251780
48PRKCH1.14417374
49TESK11.13878205
50PTK2B1.12210905
51TRPM71.10690505
52PDGFRB1.08450494
53TIE11.07756944
54PTK21.05063124
55PIK3CA1.04470772
56OBSCN1.03988843
57MARK21.02671363
58UHMK11.01279927
59MAP2K31.01076739
60RPS6KA21.00720576
61MAP3K110.98470428
62ABL20.97089849
63PAK20.96884101
64NTRK10.95851095
65CDC42BPA0.95473542
66TGFBR10.94645997
67ROCK10.93185674
68RET0.91510273
69TBK10.89839683
70CAMK2D0.89537239
71IRAK20.87200893
72MARK10.86589540
73CAMK1D0.84712050
74MYLK0.84042754
75LIMK10.82410388
76PDPK10.82175229
77KDR0.81902817
78STK240.80182350
79PDK30.78304362
80PDK40.78304362
81ILK0.77715330
82MAP3K60.77686570
83EPHB20.76930463
84BCR0.76848454
85MAP3K10.76781213
86SGK4940.75461579
87SGK2230.75461579
88CHUK0.74305840
89FGFR40.74240139
90MTOR0.73406243
91IRAK40.73386234
92EPHA30.71926880
93JAK30.71124105
94STK380.71097285
95FER0.70490092
96MAP3K80.70182222
97PDK20.69181515
98BRAF0.67165064
99RPS6KC10.66816948
100RPS6KL10.66816948
101IKBKB0.66173751
102MAPKAPK50.66141984
103CSNK1A1L0.64222487
104MATK0.62963452
105STK110.62052002
106FLT30.61744331
107GRK70.61264702
108ALK0.61156846
109MAP3K100.60740193
110LRRK20.59577657
111PRKD20.59043698
112SIK20.58978765
113KSR20.58879173
114ERN10.58323728
115CDK50.57976999
116PDK10.57939132
117TAOK10.54945272
118CAMK2B0.54729119
119STK100.52904616
120NEK60.51328511
121MAPK120.51257896
122FYN0.51053437
123MAP3K130.50710429
124ERBB40.50678996
125LATS20.49778789
126JAK10.49743371
127MAP3K90.49562572
128RPS6KA60.48560984
129CAMK2G0.48373902
130PRKAA20.48227389
131PRKCE0.48141000
132PRKCQ0.47941955
133CSK0.47309506
134FGFR10.45587892
135CLK10.43417356
136GSK3A0.43171519
137ZAP700.43152392
138CAMK2A0.43008838
139SRC0.42834684
140CAMKK10.41231527
141MAP3K20.40574008
142SIK30.39365536
143SGK30.39303808
144CDK60.37738072
145DAPK30.37587552
146PRKG20.37162899
147SGK10.36804591
148HIPK20.35987846
149FGR0.35718299
150MAPKAPK30.35163206
151RPS6KA10.32850197
152MAPKAPK20.31709386
153NEK90.31399467

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.07227487
2Bladder cancer_Homo sapiens_hsa052192.43548974
3Dilated cardiomyopathy_Homo sapiens_hsa054142.34911682
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.08738773
5Other glycan degradation_Homo sapiens_hsa005112.06743716
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.01930730
7Notch signaling pathway_Homo sapiens_hsa043301.84783790
8TNF signaling pathway_Homo sapiens_hsa046681.73580056
9ECM-receptor interaction_Homo sapiens_hsa045121.72103053
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.68343124
11Prion diseases_Homo sapiens_hsa050201.68251179
12Lysosome_Homo sapiens_hsa041421.58124858
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56452295
14Focal adhesion_Homo sapiens_hsa045101.55079455
15Acute myeloid leukemia_Homo sapiens_hsa052211.54096138
16Malaria_Homo sapiens_hsa051441.50362477
17Salmonella infection_Homo sapiens_hsa051321.49992523
18Axon guidance_Homo sapiens_hsa043601.49122344
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.48517238
20Fatty acid elongation_Homo sapiens_hsa000621.45563010
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43365241
22MicroRNAs in cancer_Homo sapiens_hsa052061.40483615
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39396319
24Renal cell carcinoma_Homo sapiens_hsa052111.37731025
25Shigellosis_Homo sapiens_hsa051311.33406144
26Fatty acid metabolism_Homo sapiens_hsa012121.27236705
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.25483543
28Cardiac muscle contraction_Homo sapiens_hsa042601.25116873
29Tight junction_Homo sapiens_hsa045301.24623468
30Dorso-ventral axis formation_Homo sapiens_hsa043201.23903226
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22922285
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.21729285
33Gastric acid secretion_Homo sapiens_hsa049711.21226955
34Osteoclast differentiation_Homo sapiens_hsa043801.20647617
35Apoptosis_Homo sapiens_hsa042101.16694454
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16562474
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11928425
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11687368
39Viral myocarditis_Homo sapiens_hsa054161.11272501
40Fatty acid biosynthesis_Homo sapiens_hsa000611.11187977
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11151311
42Hepatitis C_Homo sapiens_hsa051601.10001591
43Pertussis_Homo sapiens_hsa051331.09150002
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08853421
45Proteoglycans in cancer_Homo sapiens_hsa052051.08825302
46p53 signaling pathway_Homo sapiens_hsa041151.07314195
47Propanoate metabolism_Homo sapiens_hsa006401.06667322
48Amoebiasis_Homo sapiens_hsa051461.05291508
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04111669
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01410412
51Thyroid cancer_Homo sapiens_hsa052161.00691393
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00592934
53Nitrogen metabolism_Homo sapiens_hsa009101.00336977
54Galactose metabolism_Homo sapiens_hsa000521.00174658
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00071806
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99894885
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.99594539
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98614289
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98344054
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.98095217
61Influenza A_Homo sapiens_hsa051640.97480032
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97202102
63Circadian entrainment_Homo sapiens_hsa047130.95696781
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.94607937
65Pathways in cancer_Homo sapiens_hsa052000.94501776
66Fatty acid degradation_Homo sapiens_hsa000710.93946517
67Renin secretion_Homo sapiens_hsa049240.93778774
68Sphingolipid metabolism_Homo sapiens_hsa006000.93138212
69Hepatitis B_Homo sapiens_hsa051610.93104451
70Type II diabetes mellitus_Homo sapiens_hsa049300.91907055
71Endocytosis_Homo sapiens_hsa041440.91588626
72Prolactin signaling pathway_Homo sapiens_hsa049170.90877899
73VEGF signaling pathway_Homo sapiens_hsa043700.90137403
74Prostate cancer_Homo sapiens_hsa052150.89985347
75Oxytocin signaling pathway_Homo sapiens_hsa049210.89375411
76Salivary secretion_Homo sapiens_hsa049700.89069529
77ErbB signaling pathway_Homo sapiens_hsa040120.88298105
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.87678337
79Insulin resistance_Homo sapiens_hsa049310.86819211
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86106867
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86094102
82cAMP signaling pathway_Homo sapiens_hsa040240.83724647
83Glutamatergic synapse_Homo sapiens_hsa047240.83433525
84Non-small cell lung cancer_Homo sapiens_hsa052230.83415818
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82936068
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82629190
87Cholinergic synapse_Homo sapiens_hsa047250.82421986
88Gap junction_Homo sapiens_hsa045400.80453697
89Protein digestion and absorption_Homo sapiens_hsa049740.80089101
90PPAR signaling pathway_Homo sapiens_hsa033200.80044439
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78487316
92Vibrio cholerae infection_Homo sapiens_hsa051100.77808669
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77696143
94Tuberculosis_Homo sapiens_hsa051520.77572677
95GnRH signaling pathway_Homo sapiens_hsa049120.77293884
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77120029
97GABAergic synapse_Homo sapiens_hsa047270.76904882
98Pancreatic secretion_Homo sapiens_hsa049720.76819851
99Adherens junction_Homo sapiens_hsa045200.75929192
100Basal cell carcinoma_Homo sapiens_hsa052170.75693282
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74927629
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74061481
103Rap1 signaling pathway_Homo sapiens_hsa040150.73864618
104Estrogen signaling pathway_Homo sapiens_hsa049150.73831057
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73469357
106Ras signaling pathway_Homo sapiens_hsa040140.73336784
107Steroid biosynthesis_Homo sapiens_hsa001000.73286127
108Ether lipid metabolism_Homo sapiens_hsa005650.72379588
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71561174
110Melanoma_Homo sapiens_hsa052180.71534712
111Hippo signaling pathway_Homo sapiens_hsa043900.71339699
112MAPK signaling pathway_Homo sapiens_hsa040100.71019370
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70878634
114Morphine addiction_Homo sapiens_hsa050320.70861316
115Butanoate metabolism_Homo sapiens_hsa006500.70836230
116Small cell lung cancer_Homo sapiens_hsa052220.70538288
117AMPK signaling pathway_Homo sapiens_hsa041520.70214194
118HTLV-I infection_Homo sapiens_hsa051660.70174334
119African trypanosomiasis_Homo sapiens_hsa051430.70033828
120Platelet activation_Homo sapiens_hsa046110.69336616
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.69190251
122Leishmaniasis_Homo sapiens_hsa051400.68315757
123Chronic myeloid leukemia_Homo sapiens_hsa052200.68017555
124Glioma_Homo sapiens_hsa052140.67618579
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65198723
126B cell receptor signaling pathway_Homo sapiens_hsa046620.65052024
127Choline metabolism in cancer_Homo sapiens_hsa052310.64032758
128Melanogenesis_Homo sapiens_hsa049160.63653693
129Lysine degradation_Homo sapiens_hsa003100.62998539
130Toxoplasmosis_Homo sapiens_hsa051450.62495499
131Ovarian steroidogenesis_Homo sapiens_hsa049130.62436518
132Calcium signaling pathway_Homo sapiens_hsa040200.62295976
133Measles_Homo sapiens_hsa051620.62274140
134Pancreatic cancer_Homo sapiens_hsa052120.61044789
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60856770
136Insulin signaling pathway_Homo sapiens_hsa049100.60764970
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60651543
138Legionellosis_Homo sapiens_hsa051340.60160466
139Viral carcinogenesis_Homo sapiens_hsa052030.59245128
140Cocaine addiction_Homo sapiens_hsa050300.59092338
141Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58950268
142HIF-1 signaling pathway_Homo sapiens_hsa040660.57305412
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56400809
144mTOR signaling pathway_Homo sapiens_hsa041500.55873882
145Insulin secretion_Homo sapiens_hsa049110.54844440
146Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54392769
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54291128
148Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53946873
149Fructose and mannose metabolism_Homo sapiens_hsa000510.53857627
150Long-term depression_Homo sapiens_hsa047300.53794330
151Sulfur relay system_Homo sapiens_hsa041220.53221585
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.53052964
153Endometrial cancer_Homo sapiens_hsa052130.52930722
154Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52240570
155Long-term potentiation_Homo sapiens_hsa047200.52062339
156Rheumatoid arthritis_Homo sapiens_hsa053230.51075108

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