MICALL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.23829999
2mannose metabolic process (GO:0006013)4.82458406
3semaphorin-plexin signaling pathway (GO:0071526)4.79231340
4protoporphyrinogen IX biosynthetic process (GO:0006782)4.64568351
5erythrocyte maturation (GO:0043249)4.09303517
6angiotensin maturation (GO:0002003)4.04576510
7heme biosynthetic process (GO:0006783)4.01832600
8porphyrin-containing compound biosynthetic process (GO:0006779)3.87959552
9endothelial cell chemotaxis (GO:0035767)3.80284723
10desmosome organization (GO:0002934)3.53880609
11Golgi transport vesicle coating (GO:0048200)3.51152814
12COPI coating of Golgi vesicle (GO:0048205)3.51152814
13chondrocyte proliferation (GO:0035988)3.50651248
14adhesion of symbiont to host cell (GO:0044650)3.50106945
15virion attachment to host cell (GO:0019062)3.50106945
16cell adhesion mediated by integrin (GO:0033627)3.43861651
17adhesion of symbiont to host (GO:0044406)3.42529246
18tetrapyrrole biosynthetic process (GO:0033014)3.41092897
19antigen processing and presentation of endogenous antigen (GO:0019883)3.40928408
20hepatocyte apoptotic process (GO:0097284)3.34369024
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32044897
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32044897
23regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.27380958
24regulation of glucose import in response to insulin stimulus (GO:2001273)3.20076025
25protein retention in ER lumen (GO:0006621)3.19862162
26Arp2/3 complex-mediated actin nucleation (GO:0034314)3.19312104
27renal filtration (GO:0097205)3.18496760
28skin morphogenesis (GO:0043589)3.18106941
29actin filament depolymerization (GO:0030042)3.15247495
30heme metabolic process (GO:0042168)3.13035607
31cell volume homeostasis (GO:0006884)3.10394028
32positive regulation of Cdc42 GTPase activity (GO:0043089)3.08502862
33erythrocyte development (GO:0048821)3.08282724
34regulation of cholesterol homeostasis (GO:2000188)3.06234055
35regulation of cholesterol metabolic process (GO:0090181)3.02115159
36porphyrin-containing compound metabolic process (GO:0006778)3.00829302
37glycosphingolipid catabolic process (GO:0046479)3.00415653
38cell-cell junction maintenance (GO:0045217)2.98527195
39epithelial cell-cell adhesion (GO:0090136)2.97982493
40regulation of extracellular matrix disassembly (GO:0010715)2.96661626
41NADH metabolic process (GO:0006734)2.96184075
42positive regulation of p38MAPK cascade (GO:1900745)2.95139458
43regulation of ARF GTPase activity (GO:0032312)2.93669875
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90195545
45positive regulation by organism of defense response of other organism involved in symbiotic interact2.90195545
46modulation by symbiont of host immune response (GO:0052553)2.90195545
47positive regulation by symbiont of host defense response (GO:0052509)2.90195545
48modulation by symbiont of host defense response (GO:0052031)2.90195545
49modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.90195545
50regulation of integrin activation (GO:0033623)2.88708274
51negative regulation of fatty acid transport (GO:2000192)2.88528763
52peptide catabolic process (GO:0043171)2.86913193
53fat-soluble vitamin biosynthetic process (GO:0042362)2.85413757
54NIK/NF-kappaB signaling (GO:0038061)2.85198368
55retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.83953478
56positive regulation of receptor recycling (GO:0001921)2.80848318
57cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.80142262
58glucose 6-phosphate metabolic process (GO:0051156)2.80033125
59glycolipid catabolic process (GO:0019377)2.79956356
60vascular endothelial growth factor signaling pathway (GO:0038084)2.78769607
61GDP-mannose metabolic process (GO:0019673)2.78200162
62negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.78133026
63positive regulation of pseudopodium assembly (GO:0031274)2.78025969
64regulation of protein heterodimerization activity (GO:0043497)2.77034615
65regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76951940
66atrioventricular valve morphogenesis (GO:0003181)2.76800695
67vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76662908
68positive regulation of natural killer cell differentiation (GO:0032825)2.75670445
69regulation of cholesterol biosynthetic process (GO:0045540)2.75288853
70activation of Rac GTPase activity (GO:0032863)2.75181317
71hemoglobin metabolic process (GO:0020027)2.73818989
72regulation of interferon-beta biosynthetic process (GO:0045357)2.73014174
73glomerular filtration (GO:0003094)2.71150749
74proline biosynthetic process (GO:0006561)2.70335591
75branching involved in mammary gland duct morphogenesis (GO:0060444)2.69722635
76response to interferon-alpha (GO:0035455)2.68025436
77negative regulation of cell size (GO:0045792)2.65195739
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.65094824
79endodermal cell differentiation (GO:0035987)2.64083772
80basement membrane organization (GO:0071711)2.63190499
81decidualization (GO:0046697)2.62635333
82actin nucleation (GO:0045010)2.62280631
83regulation of erythrocyte differentiation (GO:0045646)2.61824386
84intestinal absorption (GO:0050892)2.61719904
85hemidesmosome assembly (GO:0031581)2.61383184
86positive regulation of histone deacetylation (GO:0031065)2.61201108
87adherens junction assembly (GO:0034333)2.58198710
88low-density lipoprotein particle clearance (GO:0034383)2.57941196
89hyaluronan catabolic process (GO:0030214)2.57699035
90fructose metabolic process (GO:0006000)2.57339774
91dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.57088306
92regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.56476079
93cell-substrate junction assembly (GO:0007044)2.55739462
94regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.54763833
95negative regulation of interleukin-8 production (GO:0032717)2.51908391
96planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50571711
97cytoskeletal anchoring at plasma membrane (GO:0007016)2.50399134
98barbed-end actin filament capping (GO:0051016)2.50324604
99positive regulation of lipoprotein lipase activity (GO:0051006)2.49783093
100positive regulation of triglyceride lipase activity (GO:0061365)2.49783093
101platelet aggregation (GO:0070527)2.49550006
102embryonic hemopoiesis (GO:0035162)2.49465730
103urea cycle (GO:0000050)2.49175104
104regulation of guanylate cyclase activity (GO:0031282)2.48832769
105renal system process involved in regulation of blood volume (GO:0001977)2.48800066
106positive regulation of endothelial cell apoptotic process (GO:2000353)2.48590836
107regulation of apoptotic cell clearance (GO:2000425)2.48195672
108modulation by symbiont of host cellular process (GO:0044068)2.48153668
109antigen processing and presentation via MHC class Ib (GO:0002475)2.46785028
110T cell apoptotic process (GO:0070231)2.46697091
111complement activation, classical pathway (GO:0006958)2.46111627
112peptidyl-tyrosine autophosphorylation (GO:0038083)2.46043948
113negative regulation of viral entry into host cell (GO:0046597)2.45968998
114actin filament capping (GO:0051693)2.44986855
115sequestering of metal ion (GO:0051238)2.44250735
116definitive hemopoiesis (GO:0060216)2.44197493
117regulation of endothelial cell chemotaxis (GO:2001026)2.41798884
118myeloid cell development (GO:0061515)2.41717639
119activation of MAPKKK activity (GO:0000185)2.41138308
120regulation of vitamin metabolic process (GO:0030656)2.41040357
121mesodermal cell differentiation (GO:0048333)2.41030551
122response to arsenic-containing substance (GO:0046685)2.40962184
123glutathione biosynthetic process (GO:0006750)2.40890270
124protein heterotrimerization (GO:0070208)2.38911685
125positive regulation of protein kinase C signaling (GO:0090037)2.38771492
126execution phase of apoptosis (GO:0097194)2.38005636
127axon extension involved in axon guidance (GO:0048846)2.37996049
128neuron projection extension involved in neuron projection guidance (GO:1902284)2.37996049
129regulation of response to osmotic stress (GO:0047484)2.37280200
130response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.37252968
131response to host immune response (GO:0052572)2.37252968
132positive regulation of blood vessel endothelial cell migration (GO:0043536)2.36262794
133platelet formation (GO:0030220)2.36159040
134wound healing, spreading of epidermal cells (GO:0035313)2.35884615
135urea metabolic process (GO:0019627)2.35447450
136activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.35318377
137regulation of pseudopodium assembly (GO:0031272)2.35125629
138cell-substrate adherens junction assembly (GO:0007045)2.34949886
139focal adhesion assembly (GO:0048041)2.34949886
140apoptotic cell clearance (GO:0043277)2.34501668
141negative regulation of bone mineralization (GO:0030502)2.34156700
142regulation of extracellular matrix organization (GO:1903053)2.33873025
143positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.33506872
144positive regulation of extracellular matrix organization (GO:1903055)2.33090108
145response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.32600850
146response to host (GO:0075136)2.32600850
147response to host defenses (GO:0052200)2.32600850
148regulation of early endosome to late endosome transport (GO:2000641)2.31349475
149myelin maintenance (GO:0043217)2.30762400
150protein localization to endosome (GO:0036010)2.30762368
151sodium ion export (GO:0071436)2.30630099
152positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.30577766
153multicellular organismal catabolic process (GO:0044243)2.29440910
154myeloid cell homeostasis (GO:0002262)2.29129179
155positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.29107107
156maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.28987612
157negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.28757323
158negative regulation of erythrocyte differentiation (GO:0045647)2.28737722
159positive regulation of natural killer cell activation (GO:0032816)2.28675278
160glutamine family amino acid biosynthetic process (GO:0009084)2.28409933
161proline metabolic process (GO:0006560)2.27811513
162ceramide catabolic process (GO:0046514)2.27802441
163response to muramyl dipeptide (GO:0032495)2.27539784
164negative regulation of viral release from host cell (GO:1902187)2.27452533
165granulocyte differentiation (GO:0030851)2.26551896
166immunoglobulin mediated immune response (GO:0016064)2.26422739
167actin filament bundle assembly (GO:0051017)2.26131607
168actin filament bundle organization (GO:0061572)2.26131607
169substrate-dependent cell migration (GO:0006929)2.25370426
170negative regulation of focal adhesion assembly (GO:0051895)2.25277867
171negative regulation of cell junction assembly (GO:1901889)2.25277867
172negative regulation of adherens junction organization (GO:1903392)2.25277867
173regulation of natural killer cell differentiation (GO:0032823)2.25117207
174neutrophil activation involved in immune response (GO:0002283)2.25033442
175negative regulation of biomineral tissue development (GO:0070168)2.24623314
176regulation of cholesterol storage (GO:0010885)2.24589026
177epoxygenase P450 pathway (GO:0019373)2.24556374
178natural killer cell differentiation (GO:0001779)2.23911194
1793-UTR-mediated mRNA stabilization (GO:0070935)2.23580209
180pentose-phosphate shunt (GO:0006098)2.23455915
181negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.23096494
182response to laminar fluid shear stress (GO:0034616)2.22026679
183response to UV-C (GO:0010225)2.21319767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.24269877
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.45236550
3E2F7_22180533_ChIP-Seq_HELA_Human3.39909061
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01193008
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99948673
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.89525295
7VDR_21846776_ChIP-Seq_THP-1_Human2.60262061
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55808061
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.49773427
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.49611703
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.46152470
12* SCL_19346495_ChIP-Seq_HPC-7_Human2.34117147
13* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20978762
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20296707
15* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19720359
16* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.12230043
17TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.11095882
18* ELK3_25401928_ChIP-Seq_HUVEC_Human2.08603529
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.05939412
20MYC_22102868_ChIP-Seq_BL_Human2.04151043
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01407627
22KDM2B_26808549_Chip-Seq_K562_Human1.97963364
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97918028
24VDR_24763502_ChIP-Seq_THP-1_Human1.95952227
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93794822
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92754861
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.88836318
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86777222
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84910990
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.83291028
31GATA1_19941826_ChIP-Seq_K562_Human1.82500650
32* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79624364
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79400654
34* TCF7_22412390_ChIP-Seq_EML_Mouse1.78726406
35* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.76659980
36* ERG_21242973_ChIP-ChIP_JURKAT_Human1.74596795
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71702833
38CLOCK_20551151_ChIP-Seq_293T_Human1.71357361
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70827232
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68899776
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.68470483
42* GATA1_19941827_ChIP-Seq_MEL_Mouse1.65714269
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65301038
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64378597
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.64089029
46* P68_20966046_ChIP-Seq_HELA_Human1.63781071
47* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.62649727
48LXR_22292898_ChIP-Seq_THP-1_Human1.59698564
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.59426257
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57753221
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57301067
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55867675
53SMC4_20622854_ChIP-Seq_HELA_Human1.55132030
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.54698888
55MAF_26560356_Chip-Seq_TH1_Human1.54212923
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52672806
57* RUNX1_27514584_Chip-Seq_MCF-7_Human1.52075886
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51400566
59* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.51064636
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.50946766
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50519843
62* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48953550
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48668216
64* CREB1_26743006_Chip-Seq_LNCaP_Human1.46375248
65* ATF3_27146783_Chip-Seq_COLON_Human1.45803708
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.44719213
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.43697189
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.43454692
69* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43321516
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42784069
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42704288
72* RACK7_27058665_Chip-Seq_MCF-7_Human1.42219858
73PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41053321
74* GATA2_19941826_ChIP-Seq_K562_Human1.40916928
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39423693
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38594895
77* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38545351
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37982605
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37955914
80CTCF_27219007_Chip-Seq_Bcells_Human1.37855148
81* RUNX1_22412390_ChIP-Seq_EML_Mouse1.37765440
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37743507
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35439237
84GATA1_22025678_ChIP-Seq_K562_Human1.35155071
85UTX_26944678_Chip-Seq_JUKART_Human1.33638483
86* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33350202
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32194458
88* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31448391
89* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31448391
90AR_21909140_ChIP-Seq_LNCAP_Human1.31388247
91KDM2B_26808549_Chip-Seq_DND41_Human1.31369385
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29418736
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29350127
94BCOR_27268052_Chip-Seq_Bcells_Human1.28318543
95GATA6_25053715_ChIP-Seq_YYC3_Human1.27979655
96* NCOR1_26117541_ChIP-Seq_K562_Human1.27073137
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23396896
98SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22561105
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20581809
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20287726
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.19323806
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19076696
103* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19010565
104TP63_22573176_ChIP-Seq_HFKS_Human1.18920604
105SPI1_23547873_ChIP-Seq_NB4_Human1.18364364
106BCL6_27268052_Chip-Seq_Bcells_Human1.16798379
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16285439
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16283812
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15479298
110ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14611551
111STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14348555
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14256163
113P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14223431
114KDM2B_26808549_Chip-Seq_JURKAT_Human1.13935308
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13654912
116NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13519445
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13221418
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12228145
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11518244
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11301318
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09031005
122ELF1_20517297_ChIP-Seq_JURKAT_Human1.08958126
123DROSHA_22980978_ChIP-Seq_HELA_Human1.08349564
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07323642
125TFEB_21752829_ChIP-Seq_HELA_Human1.07244192
126LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06744125
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06640600
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06323891
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06178597
130STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05492074
131MYB_26560356_Chip-Seq_TH2_Human1.05240887
132TP53_22127205_ChIP-Seq_IMR90_Human1.04071527
133SA1_27219007_Chip-Seq_Bcells_Human1.03777282
134KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.03006762
135SPI1_23127762_ChIP-Seq_K562_Human1.02942174
136* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02683380
137UBF1/2_26484160_Chip-Seq_HMECs_Human1.02215927
138* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02048518
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01958450
140TET1_21490601_ChIP-Seq_MESCs_Mouse1.01803565
141ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01706760
142ZNF263_19887448_ChIP-Seq_K562_Human1.01633513
143FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00757388
144JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99323427
145SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99305901
146FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98822486
147SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98515782
148KLF5_25053715_ChIP-Seq_YYC3_Human0.98086159
149* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97830841
150PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97748538
151E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97706058
152* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97372233
153* GATA4_25053715_ChIP-Seq_YYC3_Human0.97359354
154SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96813975
155TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95079343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.75988130
2MP0003656_abnormal_erythrocyte_physiolo3.55450899
3MP0003705_abnormal_hypodermis_morpholog3.32910733
4MP0010352_gastrointestinal_tract_polyps2.87433913
5MP0005409_darkened_coat_color2.79111716
6MP0004858_abnormal_nervous_system2.76543142
7MP0002254_reproductive_system_inflammat2.74189791
8MP0008438_abnormal_cutaneous_collagen2.70646318
9MP0003300_gastrointestinal_ulcer2.62668958
10MP0000685_abnormal_immune_system2.53532172
11MP0005397_hematopoietic_system_phenotyp2.32171416
12MP0001545_abnormal_hematopoietic_system2.32171416
13MP0009278_abnormal_bone_marrow2.31237760
14MP0000678_abnormal_parathyroid_gland2.23587081
15MP0003566_abnormal_cell_adhesion2.20076317
16MP0002139_abnormal_hepatobiliary_system2.15726804
17MP0001348_abnormal_lacrimal_gland2.15465487
18MP0003303_peritoneal_inflammation2.12882980
19MP0003172_abnormal_lysosome_physiology2.08714995
20MP0006054_spinal_hemorrhage2.08292378
21MP0002877_abnormal_melanocyte_morpholog2.05058792
22MP0004147_increased_porphyrin_level1.98955536
23MP0005451_abnormal_body_composition1.98845537
24MP0005275_abnormal_skin_tensile1.92411005
25MP0005023_abnormal_wound_healing1.87804400
26MP0003329_amyloid_beta_deposits1.85931467
27MP0003279_aneurysm1.85120192
28MP0008260_abnormal_autophagy1.80785967
29MP0003436_decreased_susceptibility_to1.77463102
30MP0004808_abnormal_hematopoietic_stem1.77264264
31MP0010307_abnormal_tumor_latency1.71950918
32MP0004019_abnormal_vitamin_homeostasis1.67696974
33MP0005076_abnormal_cell_differentiation1.67364711
34MP0004947_skin_inflammation1.66068994
35MP0001873_stomach_inflammation1.64522837
36MP0003091_abnormal_cell_migration1.62080080
37MP0000490_abnormal_crypts_of1.58728626
38MP0009785_altered_susceptibility_to1.58197089
39MP0003283_abnormal_digestive_organ1.54939489
40MP0005464_abnormal_platelet_physiology1.54887740
41MP0009840_abnormal_foam_cell1.52213938
42MP0005365_abnormal_bile_salt1.51420431
43MP0005083_abnormal_biliary_tract1.50288458
44MP0003448_altered_tumor_morphology1.49616177
45MP0002396_abnormal_hematopoietic_system1.47032873
46MP0003191_abnormal_cellular_cholesterol1.46002149
47MP0001666_abnormal_nutrient_absorption1.44271116
48MP0002796_impaired_skin_barrier1.42941947
49MP0000858_altered_metastatic_potential1.42806502
50MP0001664_abnormal_digestion1.38839644
51MP0002249_abnormal_larynx_morphology1.37468492
52MP0001849_ear_inflammation1.36271887
53MP0010155_abnormal_intestine_physiology1.35683389
54MP0000343_altered_response_to1.34113877
55MP0001835_abnormal_antigen_presentation1.33464217
56MP0001346_abnormal_lacrimal_gland1.33140046
57MP0002896_abnormal_bone_mineralization1.31355243
58MP0002060_abnormal_skin_morphology1.30740343
59MP0009379_abnormal_foot_pigmentation1.28052333
60MP0009333_abnormal_splenocyte_physiolog1.27022936
61MP0003879_abnormal_hair_cell1.26488774
62MP0005025_abnormal_response_to1.25729963
63MP0000566_synostosis1.24374599
64MP0003453_abnormal_keratinocyte_physiol1.23910582
65MP0001533_abnormal_skeleton_physiology1.23726694
66MP0000604_amyloidosis1.22264918
67MP0005310_abnormal_salivary_gland1.21654341
68MP0002419_abnormal_innate_immunity1.21175746
69MP0001958_emphysema1.19899284
70MP0003183_abnormal_peptide_metabolism1.17569496
71MP0004272_abnormal_basement_membrane1.16994445
72MP0000733_abnormal_muscle_development1.16452278
73MP0002405_respiratory_system_inflammati1.15018637
74MP0010030_abnormal_orbit_morphology1.13693865
75MP0005257_abnormal_intraocular_pressure1.13054718
76MP0000462_abnormal_digestive_system1.12171908
77MP0005666_abnormal_adipose_tissue1.11566938
78MP0005503_abnormal_tendon_morphology1.10917684
79MP0010234_abnormal_vibrissa_follicle1.09768385
80MP0006082_CNS_inflammation1.07955114
81MP0005000_abnormal_immune_tolerance1.06782738
82MP0002089_abnormal_postnatal_growth/wei1.06521552
83MP0000003_abnormal_adipose_tissue1.05731651
84MP0002998_abnormal_bone_remodeling1.04504998
85MP0002398_abnormal_bone_marrow1.04154386
86MP0000751_myopathy1.01487235
87MP0001790_abnormal_immune_system1.00778373
88MP0005387_immune_system_phenotype1.00778373
89MP0003878_abnormal_ear_physiology1.00708546
90MP0005377_hearing/vestibular/ear_phenot1.00708546
91MP0002098_abnormal_vibrissa_morphology1.00683326
92MP0002452_abnormal_antigen_presenting1.00590867
93MP0000537_abnormal_urethra_morphology0.99268729
94MP0005166_decreased_susceptibility_to0.98894100
95MP0002148_abnormal_hypersensitivity_rea0.98310997
96MP0005375_adipose_tissue_phenotype0.97517469
97MP0002166_altered_tumor_susceptibility0.96263133
98MP0002933_joint_inflammation0.95634291
99MP0005390_skeleton_phenotype0.95451813
100MP0009643_abnormal_urine_homeostasis0.95394833
101MP0009931_abnormal_skin_appearance0.94253871
102MP0005508_abnormal_skeleton_morphology0.93363390
103MP0008004_abnormal_stomach_pH0.91810686
104MP0001243_abnormal_dermal_layer0.91719455
105MP0009384_cardiac_valve_regurgitation0.91652909
106MP0001845_abnormal_inflammatory_respons0.91054198
107MP0004510_myositis0.90868461
108MP0005501_abnormal_skin_physiology0.90704261
109MP0005670_abnormal_white_adipose0.90374700
110MP0005058_abnormal_lysosome_morphology0.89420193
111MP0000467_abnormal_esophagus_morphology0.89392119
112MP0003634_abnormal_glial_cell0.88724161
113MP0000477_abnormal_intestine_morphology0.88679193
114MP0005623_abnormal_meninges_morphology0.88455452
115MP0008007_abnormal_cellular_replicative0.86862465
116MP0002429_abnormal_blood_cell0.85833664
117MP0001819_abnormal_immune_cell0.85579459
118MP0000350_abnormal_cell_proliferation0.85342283
119MP0005595_abnormal_vascular_smooth0.84189598
120MP0003111_abnormal_nucleus_morphology0.83944478
121MP0002722_abnormal_immune_system0.83835528
122MP0000767_abnormal_smooth_muscle0.83256318
123MP0005621_abnormal_cell_physiology0.83217971
124MP0002420_abnormal_adaptive_immunity0.82902514
125MP0001663_abnormal_digestive_system0.82552109
126MP0000681_abnormal_thyroid_gland0.82431666
127MP0005381_digestive/alimentary_phenotyp0.82257446
128MP0004264_abnormal_extraembryonic_tissu0.82059133
129MP0004782_abnormal_surfactant_physiolog0.82030389
130MP0000013_abnormal_adipose_tissue0.81442407
131MP0002723_abnormal_immune_serum0.78151248
132MP0003045_fibrosis0.78144736
133MP0005164_abnormal_response_to0.77306028
134MP0002006_tumorigenesis0.77243356
135MP0003866_abnormal_defecation0.77054879
136MP0001800_abnormal_humoral_immune0.77030530
137MP0001881_abnormal_mammary_gland0.76390044
138MP0001216_abnormal_epidermal_layer0.75806896
139MP0003724_increased_susceptibility_to0.75443423
140MP0000249_abnormal_blood_vessel0.75290513
141MP0003075_altered_response_to0.75140578
142MP0003795_abnormal_bone_structure0.75044626
143MP0002019_abnormal_tumor_incidence0.74500672
144MP0000579_abnormal_nail_morphology0.74449389
145MP0000689_abnormal_spleen_morphology0.74014296
146MP0004185_abnormal_adipocyte_glucose0.73348828
147MP0000538_abnormal_urinary_bladder0.71929327
148MP0001765_abnormal_ion_homeostasis0.70720627
149MP0005165_increased_susceptibility_to0.69498852
150MP0006138_congestive_heart_failure0.69488171
151MP0010329_abnormal_lipoprotein_level0.68633495

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.82700483
2Poikilocytosis (HP:0004447)4.15072816
3Premature rupture of membranes (HP:0001788)3.90805898
4Abnormality of the heme biosynthetic pathway (HP:0010472)3.90310774
5J-shaped sella turcica (HP:0002680)3.82630163
6Malnutrition (HP:0004395)3.75101488
7Reticulocytosis (HP:0001923)3.71184185
8Peritonitis (HP:0002586)3.65837631
9Systemic lupus erythematosus (HP:0002725)3.61450379
10Fragile skin (HP:0001030)3.52563471
11Obstructive sleep apnea (HP:0002870)3.50091929
12Vertebral compression fractures (HP:0002953)3.46047628
13Atrophic scars (HP:0001075)3.44756403
14Ankle contracture (HP:0006466)3.32783323
15Abnormality of glutamine family amino acid metabolism (HP:0010902)3.23891451
16Cervical subluxation (HP:0003308)3.19192288
17Pustule (HP:0200039)3.09013677
18Hemorrhage of the eye (HP:0011885)3.06852822
19Petechiae (HP:0000967)3.03065595
20Distal lower limb amyotrophy (HP:0008944)2.92197284
21Nuclear cataract (HP:0100018)2.82274911
22Abnormality of complement system (HP:0005339)2.79067751
23Abnormality of reticulocytes (HP:0004312)2.74756856
24Dysostosis multiplex (HP:0000943)2.73046751
25Hand muscle atrophy (HP:0009130)2.71917521
26Acanthocytosis (HP:0001927)2.70179136
27Shallow orbits (HP:0000586)2.66554418
28Cholelithiasis (HP:0001081)2.63306043
29Mildly elevated creatine phosphokinase (HP:0008180)2.61024609
30Increased density of long bones (HP:0006392)2.56700528
31Complement deficiency (HP:0004431)2.54403758
32Neurofibrillary tangles (HP:0002185)2.52658323
33Urinary glycosaminoglycan excretion (HP:0003541)2.52076243
34Mucopolysacchariduria (HP:0008155)2.52076243
35Eczematoid dermatitis (HP:0000976)2.51004287
36Cerebral aneurysm (HP:0004944)2.50379114
37Nonimmune hydrops fetalis (HP:0001790)2.50128481
38Increased mean platelet volume (HP:0011877)2.49935562
39Distal lower limb muscle weakness (HP:0009053)2.49696638
40Axonal loss (HP:0003447)2.48622413
41Dilatation of the ascending aorta (HP:0005111)2.47767672
42Abnormal platelet volume (HP:0011876)2.47266605
43Right ventricular cardiomyopathy (HP:0011663)2.44892053
44Abnormality of polysaccharide metabolism (HP:0011012)2.40785604
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40785604
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40785604
47Abnormality of the acetabulum (HP:0003170)2.39767806
48Increased serum ferritin (HP:0003281)2.39755526
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.36898165
50Osteolytic defects of the hand bones (HP:0009699)2.36898165
51Abnormality of the gastric mucosa (HP:0004295)2.34981530
52Glomerulonephritis (HP:0000099)2.34951893
53Interstitial pulmonary disease (HP:0006530)2.33526536
54Genu recurvatum (HP:0002816)2.33107293
55Radial bowing (HP:0002986)2.32137545
56Aortic dissection (HP:0002647)2.30857926
57Cupped ribs (HP:0000887)2.30607421
58Abnormal gallbladder physiology (HP:0012438)2.27625182
59Cholecystitis (HP:0001082)2.27625182
60Joint stiffness (HP:0001387)2.24904044
61Wrist flexion contracture (HP:0001239)2.23628755
62Neonatal short-limb short stature (HP:0008921)2.22618467
63Ileus (HP:0002595)2.22462619
64Cellulitis (HP:0100658)2.21501308
65Achilles tendon contracture (HP:0001771)2.20821356
66Flat acetabular roof (HP:0003180)2.19037674
67Aortic aneurysm (HP:0004942)2.18271690
68Bladder diverticulum (HP:0000015)2.18180667
69Hyperparathyroidism (HP:0000843)2.17628029
70Abnormal gallbladder morphology (HP:0012437)2.16503259
71Thrombocytosis (HP:0001894)2.15179753
72Abdominal distention (HP:0003270)2.13750886
73Urticaria (HP:0001025)2.12843258
74Recurrent abscess formation (HP:0002722)2.12773116
75Ulnar bowing (HP:0003031)2.12046017
76Insomnia (HP:0100785)2.09935034
77Mitral regurgitation (HP:0001653)2.09157328
78Milia (HP:0001056)2.09141170
79Increased connective tissue (HP:0009025)2.08697793
80Onycholysis (HP:0001806)2.08231026
81Autoimmune thrombocytopenia (HP:0001973)2.08003058
82Abnormality of the distal phalanx of the thumb (HP:0009617)2.07517176
83Gastrointestinal dysmotility (HP:0002579)2.07486096
84Cerebral inclusion bodies (HP:0100314)2.07236273
85Impaired platelet aggregation (HP:0003540)2.05781524
86Abnormal platelet function (HP:0011869)2.05781524
87Biconcave vertebral bodies (HP:0004586)2.05452826
88Coxa vara (HP:0002812)2.04197622
89Myositis (HP:0100614)2.04088767
90Abnormality of the Achilles tendon (HP:0005109)2.03879528
91Deformed sella turcica (HP:0002681)2.03379793
92Prolonged bleeding time (HP:0003010)2.03007754
93Bronchomalacia (HP:0002780)2.02958604
94Lower limb amyotrophy (HP:0007210)2.02830558
95Polycythemia (HP:0001901)2.02301377
96Aortic regurgitation (HP:0001659)1.99913792
97Lymphangioma (HP:0100764)1.99802178
98Slender build (HP:0001533)1.98208128
99Focal segmental glomerulosclerosis (HP:0000097)1.98099264
100Bowing of the arm (HP:0006488)1.97276306
101Bowed forearm bones (HP:0003956)1.97276306
102Tetraparesis (HP:0002273)1.96579206
103Recurrent bacterial skin infections (HP:0005406)1.96267980
104Xanthomatosis (HP:0000991)1.96174151
105Abnormality of iron homeostasis (HP:0011031)1.95873661
106Hypercortisolism (HP:0001578)1.95104169
107Disproportionate tall stature (HP:0001519)1.94132551
108Atelectasis (HP:0100750)1.93633387
109Elevated erythrocyte sedimentation rate (HP:0003565)1.93336055
110Abnormal number of erythroid precursors (HP:0012131)1.92974030
111Abnormality of the nasal mucosa (HP:0000433)1.92960044
112Spinal rigidity (HP:0003306)1.91320581
113Soft skin (HP:0000977)1.89931121
114Mitral valve prolapse (HP:0001634)1.89145249
115Deviation of the hallux (HP:0010051)1.88515192
116Increased cerebral lipofuscin (HP:0011813)1.88127583
117Segmental peripheral demyelination/remyelination (HP:0003481)1.87992235
118Diaphragmatic weakness (HP:0009113)1.87658787
119Nephritis (HP:0000123)1.86416354
120Increased IgE level (HP:0003212)1.85786772
121Hyperacusis (HP:0010780)1.85433849
122Distal upper limb amyotrophy (HP:0007149)1.85098267
123Upper limb amyotrophy (HP:0009129)1.85098267
124Blue sclerae (HP:0000592)1.83289374
125Short nail (HP:0001799)1.82881132
126Ankyloglossia (HP:0010296)1.82334540
127Bowel diverticulosis (HP:0005222)1.82258792
128Bone pain (HP:0002653)1.81117215
129Hydroxyprolinuria (HP:0003080)1.80391121
130Abnormality of proline metabolism (HP:0010907)1.80391121
131Hypophosphatemia (HP:0002148)1.80274602
132Neonatal death (HP:0003811)1.79921350
133Wormian bones (HP:0002645)1.79825661
134Abnormality of the peritoneum (HP:0002585)1.79741140
135Abnormality of transition element cation homeostasis (HP:0011030)1.79319280
136Onion bulb formation (HP:0003383)1.79215931
137Abnormality of cells of the erythroid lineage (HP:0012130)1.78768978
138Turricephaly (HP:0000262)1.78744535
139Aneurysm (HP:0002617)1.78387635
140Stridor (HP:0010307)1.78279683
141Recurrent fungal infections (HP:0002841)1.78031180
142Generalized amyotrophy (HP:0003700)1.77965612
143Broad face (HP:0000283)1.77952567
144Hallux valgus (HP:0001822)1.77316060
145Broad palm (HP:0001169)1.77087189
146Thin bony cortex (HP:0002753)1.76605333
147Supranuclear gaze palsy (HP:0000605)1.75325620
148Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75181622
149Arterial tortuosity (HP:0005116)1.75156884
150Periodontitis (HP:0000704)1.73617435
151Abnormality of the distal phalanges of the toes (HP:0010182)1.73474982
152Emphysema (HP:0002097)1.73113547
153Abnormality of liposaccharide metabolism (HP:0010968)1.72805553
154Abnormality of glycosphingolipid metabolism (HP:0004343)1.72805553
155Abnormality of glycolipid metabolism (HP:0010969)1.72805553
156Vascular tortuosity (HP:0004948)1.72583395
157Abnormal hair laboratory examination (HP:0003328)1.67594325
158Poikiloderma (HP:0001029)1.67335712
159Orchitis (HP:0100796)1.67308719
160Difficulty climbing stairs (HP:0003551)1.67000397
161Selective tooth agenesis (HP:0001592)1.66060732
162Broad metatarsal (HP:0001783)1.65672392
163Myopathic facies (HP:0002058)1.63051892
164Protuberant abdomen (HP:0001538)1.62636943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.76594385
2TRIB33.20574744
3EEF2K2.98465538
4PKN22.87945934
5CDK122.65527591
6IRAK32.56252670
7MST1R2.42907188
8TTN2.09118768
9TBK12.03842590
10PIM21.98179514
11PTK61.96018714
12PAK41.91442956
13BMX1.83355252
14LRRK21.80294134
15TAOK21.75310211
16NME21.73012196
17MAP3K101.72188886
18EPHA21.71562938
19SMG11.69222469
20SCYL21.68427678
21MAPKAPK31.67120820
22EPHB11.57565429
23MAP3K61.53389667
24DDR21.51634936
25CDC42BPA1.51534702
26PDGFRA1.50427247
27MAP3K111.47659313
28NEK21.42299120
29TYK21.37606778
30RPS6KA41.36806173
31NTRK11.35795957
32TRPM71.35244612
33STK101.34283118
34RIPK11.33894182
35MAP3K141.33228907
36JAK31.25110141
37TLK11.23802996
38KIT1.19317242
39PTK21.18092030
40MAP2K21.16983100
41MARK21.13567714
42SIK31.11463553
43MAP3K81.09643125
44FGFR41.06752753
45MAP2K61.06072227
46CHUK1.04996386
47TESK11.04102468
48IKBKE1.03515721
49RPS6KA21.01769650
50KDR1.00747838
51STK41.00702396
52DYRK1B0.97973557
53PRKD20.97830401
54PIM10.97355463
55SIK10.96807284
56RPS6KB20.96794823
57DYRK30.95238509
58PRKG20.95145759
59MATK0.94404064
60BLK0.94184086
61PAK20.93397679
62MAPK150.92124374
63MAP3K10.87896541
64CDK60.87067782
65PDPK10.86878880
66MAP3K20.86600497
67IKBKB0.84135257
68EPHA30.83880739
69TAOK30.81969635
70STK30.81738651
71MAP2K30.80420070
72TAOK10.78867501
73MTOR0.78801404
74MET0.77142684
75TYRO30.74192448
76TGFBR10.73984528
77MAP3K130.73954265
78EPHB20.73693366
79KSR20.72988880
80IRAK40.71281902
81HIPK20.69632827
82PRKD30.69467370
83RET0.69460287
84FLT30.69455428
85MAP3K70.68990753
86PRPF4B0.68870502
87ILK0.67253041
88ERBB20.66638882
89MAPKAPK20.66129546
90ZAP700.62594875
91JAK10.62477053
92RPS6KL10.62117727
93RPS6KC10.62117727
94BTK0.60712177
95MYLK0.60583549
96LATS20.60324113
97JAK20.57532872
98PAK10.56091473
99ICK0.56054175
100TESK20.55987364
101PDGFRB0.55412588
102DMPK0.54571543
103MAP4K10.53591649
104EPHA40.53284531
105LMTK20.53179419
106GRK60.52913778
107CDC70.50806602
108MAPK110.50542443
109CDK70.50538437
110LATS10.50197875
111AURKB0.50056020
112MAP2K10.49464017
113CAMK1D0.49348404
114TGFBR20.48978824
115RIPK40.47894401
116FER0.47369208
117HCK0.47006217
118RPS6KA50.45570075
119EGFR0.45082935
120CAMK2G0.44696600
121RPS6KA60.43633540
122CDK40.43276443
123SIK20.43253335
124MAP3K120.42891941
125FGFR30.42411913
126NME10.42097895
127NEK90.41301286
128MAP3K30.41153126
129EIF2AK10.40954622
130TNK20.40798058
131ABL20.39405611
132CDK90.37992296
133NTRK30.37801785
134SRC0.35318759
135ROCK10.35163572
136PRKD10.33702820
137IRAK20.33379381
138PRKAA20.33131303
139NEK60.32880331
140CAMK2B0.31447211
141PRKCI0.30681436
142DAPK20.30249535
143MAPK120.28731983
144PDK10.28463267
145ARAF0.28115184

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.75691898
2Leishmaniasis_Homo sapiens_hsa051402.52075627
3Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.50870495
4Fructose and mannose metabolism_Homo sapiens_hsa000512.50131591
5Chronic myeloid leukemia_Homo sapiens_hsa052202.13338485
6Malaria_Homo sapiens_hsa051442.12862739
7Small cell lung cancer_Homo sapiens_hsa052222.11068403
8Sulfur relay system_Homo sapiens_hsa041222.10193056
9Bladder cancer_Homo sapiens_hsa052191.97250918
10Apoptosis_Homo sapiens_hsa042101.74541800
11Toxoplasmosis_Homo sapiens_hsa051451.73274356
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.71309962
13ECM-receptor interaction_Homo sapiens_hsa045121.68393017
14TNF signaling pathway_Homo sapiens_hsa046681.66917503
15Legionellosis_Homo sapiens_hsa051341.63458204
16Osteoclast differentiation_Homo sapiens_hsa043801.62531935
17p53 signaling pathway_Homo sapiens_hsa041151.61582084
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.60628463
19Shigellosis_Homo sapiens_hsa051311.60606426
20Arginine biosynthesis_Homo sapiens_hsa002201.60117713
21Prion diseases_Homo sapiens_hsa050201.60117521
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56621327
23Systemic lupus erythematosus_Homo sapiens_hsa053221.56045185
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55540396
25Vitamin digestion and absorption_Homo sapiens_hsa049771.50525803
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.48105396
27Bile secretion_Homo sapiens_hsa049761.47643490
28Pancreatic cancer_Homo sapiens_hsa052121.46510547
29Amoebiasis_Homo sapiens_hsa051461.45105112
30Hepatitis B_Homo sapiens_hsa051611.42346198
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.40299671
32Influenza A_Homo sapiens_hsa051641.37193413
33Focal adhesion_Homo sapiens_hsa045101.37053214
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36831387
35Pertussis_Homo sapiens_hsa051331.36825212
36Proteoglycans in cancer_Homo sapiens_hsa052051.35643029
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.34786553
38Viral carcinogenesis_Homo sapiens_hsa052031.30643689
39Measles_Homo sapiens_hsa051621.29019000
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26339431
41MicroRNAs in cancer_Homo sapiens_hsa052061.26236922
42Histidine metabolism_Homo sapiens_hsa003401.25922517
43Acute myeloid leukemia_Homo sapiens_hsa052211.25418180
44Salmonella infection_Homo sapiens_hsa051321.25286040
45Caffeine metabolism_Homo sapiens_hsa002321.24764375
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21133061
47Hematopoietic cell lineage_Homo sapiens_hsa046401.20077210
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18627014
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18589215
50Tuberculosis_Homo sapiens_hsa051521.18290083
51Antigen processing and presentation_Homo sapiens_hsa046121.17630251
52Herpes simplex infection_Homo sapiens_hsa051681.14639971
53Cell cycle_Homo sapiens_hsa041101.09632888
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.09239887
55PPAR signaling pathway_Homo sapiens_hsa033201.07069502
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.05080217
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04449331
58GnRH signaling pathway_Homo sapiens_hsa049121.04439710
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02606554
60Sulfur metabolism_Homo sapiens_hsa009200.98508423
61Adherens junction_Homo sapiens_hsa045200.98208895
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96310933
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95874254
64ABC transporters_Homo sapiens_hsa020100.93614991
65Viral myocarditis_Homo sapiens_hsa054160.93342345
66B cell receptor signaling pathway_Homo sapiens_hsa046620.92045725
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.91556278
68Non-small cell lung cancer_Homo sapiens_hsa052230.90849376
69VEGF signaling pathway_Homo sapiens_hsa043700.90233107
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89610441
71Galactose metabolism_Homo sapiens_hsa000520.87721951
72HTLV-I infection_Homo sapiens_hsa051660.87302553
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.87181065
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86676964
75Platelet activation_Homo sapiens_hsa046110.86617426
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86513110
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85347117
78Hepatitis C_Homo sapiens_hsa051600.83998335
79Melanoma_Homo sapiens_hsa052180.83794798
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83153206
81Complement and coagulation cascades_Homo sapiens_hsa046100.83118542
82Renin-angiotensin system_Homo sapiens_hsa046140.80269327
83N-Glycan biosynthesis_Homo sapiens_hsa005100.79407393
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79369400
85Lysosome_Homo sapiens_hsa041420.78299572
86Mineral absorption_Homo sapiens_hsa049780.77717117
87HIF-1 signaling pathway_Homo sapiens_hsa040660.76249012
88Estrogen signaling pathway_Homo sapiens_hsa049150.76193706
89Prolactin signaling pathway_Homo sapiens_hsa049170.76020825
90Starch and sucrose metabolism_Homo sapiens_hsa005000.76012551
91Phagosome_Homo sapiens_hsa041450.74794839
92Phenylalanine metabolism_Homo sapiens_hsa003600.73905839
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73693625
94DNA replication_Homo sapiens_hsa030300.73217981
95Insulin signaling pathway_Homo sapiens_hsa049100.72520349
96Fat digestion and absorption_Homo sapiens_hsa049750.72154524
97Glioma_Homo sapiens_hsa052140.71621003
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.71491676
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70561934
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70202020
101Choline metabolism in cancer_Homo sapiens_hsa052310.69677262
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.68905795
103Arginine and proline metabolism_Homo sapiens_hsa003300.67828112
104ErbB signaling pathway_Homo sapiens_hsa040120.67534193
105Sphingolipid metabolism_Homo sapiens_hsa006000.66825274
106Endometrial cancer_Homo sapiens_hsa052130.66812299
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66722712
108Vibrio cholerae infection_Homo sapiens_hsa051100.66654866
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65921128
110Pentose phosphate pathway_Homo sapiens_hsa000300.64574619
111AMPK signaling pathway_Homo sapiens_hsa041520.64216066
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64215526
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.63626376
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62368048
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61990597
116Staphylococcus aureus infection_Homo sapiens_hsa051500.61723674
117Thyroid cancer_Homo sapiens_hsa052160.61653122
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.61573903
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60874992
120Prostate cancer_Homo sapiens_hsa052150.59410766
121Pathways in cancer_Homo sapiens_hsa052000.59214682
122Glycerolipid metabolism_Homo sapiens_hsa005610.58967997
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58854294
124mTOR signaling pathway_Homo sapiens_hsa041500.57825115
125Pancreatic secretion_Homo sapiens_hsa049720.55887480
126Chemokine signaling pathway_Homo sapiens_hsa040620.55236205
127Renal cell carcinoma_Homo sapiens_hsa052110.55060006
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.54392861
129Thyroid hormone synthesis_Homo sapiens_hsa049180.54008152
130Epstein-Barr virus infection_Homo sapiens_hsa051690.53186663
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50880273
132Protein digestion and absorption_Homo sapiens_hsa049740.50513104
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50240228
134Notch signaling pathway_Homo sapiens_hsa043300.49671914
135Other glycan degradation_Homo sapiens_hsa005110.49556029
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49078136
137Ribosome_Homo sapiens_hsa030100.49076802
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49003625
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48979236
140Axon guidance_Homo sapiens_hsa043600.47369771
141Biosynthesis of amino acids_Homo sapiens_hsa012300.46050079
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45803186
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45702463
144Endocytosis_Homo sapiens_hsa041440.45310799
145Glutathione metabolism_Homo sapiens_hsa004800.44088359
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43874681
147Insulin resistance_Homo sapiens_hsa049310.43585173
148Chemical carcinogenesis_Homo sapiens_hsa052040.43265531
149Tight junction_Homo sapiens_hsa045300.42678221
150Colorectal cancer_Homo sapiens_hsa052100.42009303
151Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41919858
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41516796

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