MICD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1germinal center formation (GO:0002467)7.32811160
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.92703422
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.90367687
4regulation of memory T cell differentiation (GO:0043380)6.59500872
5antigen processing and presentation of endogenous antigen (GO:0019883)6.26780665
6negative regulation of T-helper cell differentiation (GO:0045623)6.22792071
7negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)6.22792071
8negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)5.65005387
9regulation of T-helper 2 cell differentiation (GO:0045628)5.63318359
10negative regulation of B cell apoptotic process (GO:0002903)5.43105213
11negative regulation of type 2 immune response (GO:0002829)5.34349210
12regulation of germinal center formation (GO:0002634)5.19728375
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.11739832
14negative regulation of immunoglobulin mediated immune response (GO:0002890)5.11476266
15negative regulation of B cell mediated immunity (GO:0002713)5.11476266
16growth hormone receptor signaling pathway (GO:0060396)4.83620543
17innate immune response in mucosa (GO:0002227)4.74757875
18phagocytosis, recognition (GO:0006910)4.70368868
19negative regulation of Rho protein signal transduction (GO:0035024)4.67135478
20negative regulation of viral entry into host cell (GO:0046597)4.65248967
21negative regulation of cell killing (GO:0031342)4.58191036
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.58191036
23fatty acid elongation (GO:0030497)4.56362573
24NIK/NF-kappaB signaling (GO:0038061)4.42639802
25regulation of hypersensitivity (GO:0002883)4.40510657
26mucosal immune response (GO:0002385)4.30088583
27regulation of viral entry into host cell (GO:0046596)4.27526498
28cellular response to growth hormone stimulus (GO:0071378)4.23934222
29antigen processing and presentation via MHC class Ib (GO:0002475)4.21827318
30negative regulation of lymphocyte mediated immunity (GO:0002707)4.21509089
31organ or tissue specific immune response (GO:0002251)4.18670481
32positive regulation by symbiont of host defense response (GO:0052509)4.18261166
33modulation by symbiont of host defense response (GO:0052031)4.18261166
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18261166
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18261166
36positive regulation by organism of defense response of other organism involved in symbiotic interact4.18261166
37modulation by symbiont of host immune response (GO:0052553)4.18261166
38regulation of B cell apoptotic process (GO:0002902)4.12165649
39negative regulation of alpha-beta T cell differentiation (GO:0046639)4.12011377
40immunoglobulin mediated immune response (GO:0016064)4.09756565
41positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.08229063
42neutrophil activation involved in immune response (GO:0002283)4.05809325
43positive regulation of antigen processing and presentation (GO:0002579)3.94395373
44detection of other organism (GO:0098543)3.88461084
45response to peptidoglycan (GO:0032494)3.84051566
46regulation of myeloid leukocyte mediated immunity (GO:0002886)3.76918776
47detection of bacterium (GO:0016045)3.76454549
48myeloid leukocyte mediated immunity (GO:0002444)3.76065198
49regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.72278071
50positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.65855483
51regulation of interferon-beta biosynthetic process (GO:0045357)3.56329200
52regulation of antigen processing and presentation (GO:0002577)3.55063425
53negative regulation of cytokine production involved in immune response (GO:0002719)3.54716630
54positive regulation of natural killer cell differentiation (GO:0032825)3.53688818
55negative regulation of leukocyte mediated immunity (GO:0002704)3.53460977
56necrotic cell death (GO:0070265)3.53447327
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.50808835
58neutrophil activation (GO:0042119)3.50475275
59positive regulation of T cell mediated cytotoxicity (GO:0001916)3.47554682
60antibacterial humoral response (GO:0019731)3.46033256
61interferon-gamma-mediated signaling pathway (GO:0060333)3.45666373
62detection of external biotic stimulus (GO:0098581)3.41943300
63detection of molecule of bacterial origin (GO:0032490)3.40501244
64positive regulation of gamma-delta T cell activation (GO:0046645)3.40167933
65negative regulation of alpha-beta T cell activation (GO:0046636)3.38066428
66type I interferon signaling pathway (GO:0060337)3.37485820
67cellular response to type I interferon (GO:0071357)3.37485820
68response to type I interferon (GO:0034340)3.35901981
69JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.35750047
70positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.33617084
71B cell mediated immunity (GO:0019724)3.31661500
72antimicrobial humoral response (GO:0019730)3.30889819
73regulation of T cell mediated cytotoxicity (GO:0001914)3.29411865
74regulation of T-helper cell differentiation (GO:0045622)3.28089161
75regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.23296371
76positive regulation of T cell mediated immunity (GO:0002711)3.21372878
77regulation of B cell receptor signaling pathway (GO:0050855)3.16953311
78regulation of mast cell degranulation (GO:0043304)3.13450253
79regulation of mast cell activation involved in immune response (GO:0033006)3.10745552
80macrophage activation involved in immune response (GO:0002281)3.10413029
81negative regulation of interleukin-12 production (GO:0032695)3.10287531
82regulation of type 2 immune response (GO:0002828)3.07727569
83programmed necrotic cell death (GO:0097300)3.07224302
84defense response to Gram-positive bacterium (GO:0050830)3.06897008
85regulation of B cell mediated immunity (GO:0002712)3.06690678
86granulocyte activation (GO:0036230)3.05870840
87regulation of immunoglobulin mediated immune response (GO:0002889)3.05107575
88regulation of viral release from host cell (GO:1902186)2.98702750
89positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.98135005
90negative regulation of defense response to virus (GO:0050687)2.97040537
91regulation of T-helper 1 cell differentiation (GO:0045625)2.95771343
92regulation of isotype switching (GO:0045191)2.94977856
93regulation of T cell mediated immunity (GO:0002709)2.94904491
94phagocytosis, engulfment (GO:0006911)2.94319475
95poly(A)+ mRNA export from nucleus (GO:0016973)2.93378727
96negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.91729635
97positive regulation of adaptive immune response (GO:0002821)2.89029710
98positive regulation of T-helper 1 type immune response (GO:0002827)2.88833948
99adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.88309751
100regulation of adaptive immune response based on somatic recombination of immune receptors built from2.87798273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.85620412
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.56235228
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.48019023
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.00284377
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95698078
6SPI1_23127762_ChIP-Seq_K562_Human2.85565853
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.81552176
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.70515878
9VDR_21846776_ChIP-Seq_THP-1_Human2.53159432
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51859960
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.50270424
12VDR_24763502_ChIP-Seq_THP-1_Human2.50199955
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49392363
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.48802014
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44714695
16SCL_19346495_ChIP-Seq_HPC-7_Human2.44150875
17CIITA_25753668_ChIP-Seq_RAJI_Human2.42953089
18MAF_26560356_Chip-Seq_TH1_Human2.41822942
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.40476828
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.38104992
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33228694
22VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.29437552
23RUNX1_22412390_ChIP-Seq_EML_Mouse2.25406261
24SPI1_23547873_ChIP-Seq_NB4_Human2.20563684
25GATA1_19941826_ChIP-Seq_K562_Human2.13036950
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01432001
27GATA3_27048872_Chip-Seq_THYMUS_Human2.00478811
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91686899
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79789904
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79164284
31UTX_26944678_Chip-Seq_JUKART_Human1.78778461
32MYB_26560356_Chip-Seq_TH2_Human1.77392841
33TCF7_22412390_ChIP-Seq_EML_Mouse1.73127101
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69474388
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.68956024
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68831481
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67072835
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60578186
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59393606
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.58738289
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58222698
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58089765
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57280527
44ETS1_22383799_ChIP-Seq_G1ME_Mouse1.56023408
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55932366
46GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55867204
47MYC_22102868_ChIP-Seq_BL_Human1.55859851
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.53342904
49MAF_26560356_Chip-Seq_TH2_Human1.53150534
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51414104
51BCOR_27268052_Chip-Seq_Bcells_Human1.48768621
52P68_20966046_ChIP-Seq_HELA_Human1.46115904
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44917113
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44024342
55MYB_26560356_Chip-Seq_TH1_Human1.43534920
56HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.41650645
57E2F1_20622854_ChIP-Seq_HELA_Human1.40964152
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.40222700
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38556189
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37854251
61KDM2B_26808549_Chip-Seq_DND41_Human1.36548460
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.34993356
63PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34513371
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30685197
65GATA3_26560356_Chip-Seq_TH2_Human1.28833632
66BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.28207395
67KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.26524788
68VDR_24787735_ChIP-Seq_THP-1_Human1.23787732
69GATA2_19941826_ChIP-Seq_K562_Human1.23601667
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22951186
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.22771843
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22216146
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19255607
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18175267
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16221985
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.15909110
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13941803
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12993531
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10304143
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09392672
81ZNF274_21170338_ChIP-Seq_K562_Hela1.09320178
82BCL6_27268052_Chip-Seq_Bcells_Human1.08971953
83NCOR1_26117541_ChIP-Seq_K562_Human1.07602853
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06738911
85TFEB_21752829_ChIP-Seq_HELA_Human1.05225467
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04363390
87PHF8_20622854_ChIP-Seq_HELA_Human1.04171844
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03486002
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02667804
90RUNX_20019798_ChIP-Seq_JUKART_Human1.01915331
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00624210
92TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99885650
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99513848
94FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97119484
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96932215
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96031784
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95123949
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94047822
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93108235
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90055697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system6.04319890
2MP0004381_abnormal_hair_follicle4.49227396
3MP0001835_abnormal_antigen_presentation4.20752014
4MP0003724_increased_susceptibility_to3.88191328
5MP0000685_abnormal_immune_system3.04506587
6MP0005075_abnormal_melanosome_morpholog3.03519136
7MP0008057_abnormal_DNA_replication2.92199727
8MP0002166_altered_tumor_susceptibility2.68076063
9MP0004858_abnormal_nervous_system2.63247574
10MP0003436_decreased_susceptibility_to2.59226168
11MP0009785_altered_susceptibility_to2.51268785
12MP0005167_abnormal_blood-brain_barrier2.45978729
13MP0001790_abnormal_immune_system2.23055083
14MP0005387_immune_system_phenotype2.23055083
15MP0003300_gastrointestinal_ulcer2.20171384
16MP0001800_abnormal_humoral_immune2.11959430
17MP0005025_abnormal_response_to2.07237438
18MP0002419_abnormal_innate_immunity2.04478525
19MP0002006_tumorigenesis2.02924859
20MP0001853_heart_inflammation1.97640434
21MP0004947_skin_inflammation1.88365579
22MP0002723_abnormal_immune_serum1.88243255
23MP0002405_respiratory_system_inflammati1.87761641
24MP0005000_abnormal_immune_tolerance1.84377981
25MP0003303_peritoneal_inflammation1.80226587
26MP0002254_reproductive_system_inflammat1.80027482
27MP0002420_abnormal_adaptive_immunity1.77072392
28MP0002452_abnormal_antigen_presenting1.76919094
29MP0001819_abnormal_immune_cell1.74478702
30MP0002277_abnormal_respiratory_mucosa1.71163286
31MP0002132_abnormal_respiratory_system1.68417235
32MP0005464_abnormal_platelet_physiology1.63023099
33MP0002398_abnormal_bone_marrow1.59110188
34MP0003172_abnormal_lysosome_physiology1.59025390
35MP0005310_abnormal_salivary_gland1.58738595
36MP0004510_myositis1.57099514
37MP0006082_CNS_inflammation1.51447671
38MP0003879_abnormal_hair_cell1.48853402
39MP0000716_abnormal_immune_system1.47307022
40MP0000465_gastrointestinal_hemorrhage1.46973269
41MP0002396_abnormal_hematopoietic_system1.46183434
42MP0003866_abnormal_defecation1.46111720
43MP0004147_increased_porphyrin_level1.45080936
44MP0002148_abnormal_hypersensitivity_rea1.44932549
45MP0001542_abnormal_bone_strength1.41107097
46MP0008875_abnormal_xenobiotic_pharmacok1.38503302
47MP0010155_abnormal_intestine_physiology1.36603600
48MP0002722_abnormal_immune_system1.33232077
49MP0001845_abnormal_inflammatory_respons1.32111940
50MP0000703_abnormal_thymus_morphology1.31689386
51MP0003763_abnormal_thymus_physiology1.31530251
52MP0003195_calcinosis1.28584165
53MP0005360_urolithiasis1.27506841
54MP0005535_abnormal_body_temperature1.27203389
55MP0000689_abnormal_spleen_morphology1.25219829
56MP0005671_abnormal_response_to1.24998866
57MP0009333_abnormal_splenocyte_physiolog1.21923307
58MP0002429_abnormal_blood_cell1.21183393
59MP0001545_abnormal_hematopoietic_system1.19684957
60MP0005397_hematopoietic_system_phenotyp1.19684957
61MP0001533_abnormal_skeleton_physiology1.14771382
62MP0003191_abnormal_cellular_cholesterol1.14391153
63MP0004130_abnormal_muscle_cell1.11933484
64MP0003828_pulmonary_edema1.10896988
65MP0001873_stomach_inflammation1.10630164
66MP0003646_muscle_fatigue1.08141007
67MP0001851_eye_inflammation1.08009697
68MP0004043_abnormal_pH_regulation1.06655127
69MP0010234_abnormal_vibrissa_follicle0.99379280
70MP0009764_decreased_sensitivity_to0.97909292
71MP0002638_abnormal_pupillary_reflex0.97753938
72MP0008004_abnormal_stomach_pH0.97416623
73MP0006054_spinal_hemorrhage0.96611824
74MP0008469_abnormal_protein_level0.94109981
75MP0004808_abnormal_hematopoietic_stem0.85094950
76MP0001849_ear_inflammation0.83317397
77MP0008961_abnormal_basal_metabolism0.82807130
78MP0009278_abnormal_bone_marrow0.82061468
79MP0003091_abnormal_cell_migration0.80923239
80MP0002998_abnormal_bone_remodeling0.80003297
81MP0003221_abnormal_cardiomyocyte_apopto0.79076433
82MP0002653_abnormal_ependyma_morphology0.77380993
83MP0000609_abnormal_liver_physiology0.69572298
84MP0002971_abnormal_brown_adipose0.67940064
85MP0003795_abnormal_bone_structure0.63036389
86MP0000858_altered_metastatic_potential0.62567511
87MP0003690_abnormal_glial_cell0.61251392
88MP0002089_abnormal_postnatal_growth/wei0.59000166
89MP0005164_abnormal_response_to0.58192925
90MP0009763_increased_sensitivity_to0.57930651
91MP0001986_abnormal_taste_sensitivity0.57319968
92MP0000613_abnormal_salivary_gland0.57254118
93MP0000313_abnormal_cell_death0.55496368
94MP0002796_impaired_skin_barrier0.54173227
95MP0004883_abnormal_blood_vessel0.53927543
96MP0003075_altered_response_to0.53905358
97MP0003453_abnormal_keratinocyte_physiol0.53502178
98MP0005377_hearing/vestibular/ear_phenot0.53251968
99MP0003878_abnormal_ear_physiology0.53251968
100MP0003183_abnormal_peptide_metabolism0.53053576

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)9.85778512
2Abnormality of the fingertips (HP:0001211)6.10627087
3Large eyes (HP:0001090)5.85120274
4Chronic otitis media (HP:0000389)5.66862009
5Orchitis (HP:0100796)4.54585773
6Retrobulbar optic neuritis (HP:0100654)4.53880877
7Optic neuritis (HP:0100653)4.53880877
8Myositis (HP:0100614)4.48326936
9Mediastinal lymphadenopathy (HP:0100721)4.37401078
10Eczematoid dermatitis (HP:0000976)4.37078478
11Abnormality of the peritoneum (HP:0002585)4.27210760
12Nasal polyposis (HP:0100582)4.21084543
13Reduced subcutaneous adipose tissue (HP:0003758)3.95781928
14Gastrointestinal infarctions (HP:0005244)3.88752268
15Chronic sinusitis (HP:0011109)3.76737287
16Prolonged bleeding time (HP:0003010)3.65839597
17Microcytic anemia (HP:0001935)3.63383150
18Meningitis (HP:0001287)3.45016821
19Increased IgE level (HP:0003212)3.44333894
20Recurrent bacterial skin infections (HP:0005406)3.42756146
21Encephalitis (HP:0002383)3.39716027
22Recurrent abscess formation (HP:0002722)3.35773531
23Hypergammaglobulinemia (HP:0010702)3.35421244
24Abnormality of the nasal mucosa (HP:0000433)3.33443826
25Basal ganglia calcification (HP:0002135)3.27557968
26Abnormality of macrophages (HP:0004311)3.12912135
27Keratoconjunctivitis sicca (HP:0001097)3.09029329
28Recurrent fungal infections (HP:0002841)3.04352472
29Abnormality of the pleura (HP:0002103)2.92067118
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.91326181
31Keratoconjunctivitis (HP:0001096)2.88860886
32Recurrent gram-negative bacterial infections (HP:0005420)2.86146053
33Chest pain (HP:0100749)2.79666537
34Hypochromic microcytic anemia (HP:0004840)2.79196765
35Recurrent bronchitis (HP:0002837)2.76841718
36Peritonitis (HP:0002586)2.76413736
37Hypertriglyceridemia (HP:0002155)2.72232615
38Epistaxis (HP:0000421)2.71551561
39Hypochromic anemia (HP:0001931)2.69850917
403-Methylglutaconic aciduria (HP:0003535)2.68129775
41Spontaneous hematomas (HP:0007420)2.64857838
42Vasculitis (HP:0002633)2.63379233
43Chronic obstructive pulmonary disease (HP:0006510)2.61368065
44Obstructive lung disease (HP:0006536)2.61368065
45Arterial thrombosis (HP:0004420)2.59833679
46Gingival bleeding (HP:0000225)2.58404719
47Abnormality of alanine metabolism (HP:0010916)2.57481858
48Hyperalaninemia (HP:0003348)2.57481858
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57481858
50Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.57221943
51Petechiae (HP:0000967)2.50492047
52Arthropathy (HP:0003040)2.45767158
53Stomatitis (HP:0010280)2.45010508
54Anorexia (HP:0002039)2.44895955
55Skin rash (HP:0000988)2.40369694
56Flat occiput (HP:0005469)2.38235752
57Leukocytosis (HP:0001974)2.35250616
58Chronic mucocutaneous candidiasis (HP:0002728)2.34908512
59Recurrent cutaneous fungal infections (HP:0011370)2.34908512
60Recurrent skin infections (HP:0001581)2.34647087
61Macroglossia (HP:0000158)2.33277122
62Granulocytopenia (HP:0001913)2.31927466
63Clubbing of toes (HP:0100760)2.29322258
64Autoimmune thrombocytopenia (HP:0001973)2.27031385
65Ileus (HP:0002595)2.25824637
66Hemoptysis (HP:0002105)2.22623620
67Eosinophilia (HP:0001880)2.22482785
68Abnormality of the endocardium (HP:0004306)2.21349072
69Urticaria (HP:0001025)2.21275710
70Menorrhagia (HP:0000132)2.19094842
71Erythema (HP:0010783)2.18050806
72Prominent nose (HP:0000448)2.17675400
73Inflammation of the large intestine (HP:0002037)2.12865456
74Emphysema (HP:0002097)2.10873257
75Pulmonary infiltrates (HP:0002113)2.10775081
76Cellulitis (HP:0100658)2.10101209
77Pulmonary embolism (HP:0002204)2.08288961
78Abnormal platelet volume (HP:0011876)2.05581531
79Abnormality of iron homeostasis (HP:0011031)2.01975081
80Polycythemia (HP:0001901)2.01946326
81Increased serum ferritin (HP:0003281)2.01460382
82Episodic fever (HP:0001954)1.99614071
83Sepsis (HP:0100806)1.98311513
84Cerebellar dysplasia (HP:0007033)1.97329188
85Gastrointestinal inflammation (HP:0004386)1.92892881
86Lymphedema (HP:0001004)1.92334842
87Cardiomegaly (HP:0001640)1.91698855
88Acute lymphatic leukemia (HP:0006721)1.89449746
89Abnormality of transition element cation homeostasis (HP:0011030)1.88881268
90Delayed CNS myelination (HP:0002188)1.87518814
91Amyloidosis (HP:0011034)1.85561499
92Gingivitis (HP:0000230)1.84631177
93Increased IgM level (HP:0003496)1.84429959
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81929299
95Bronchitis (HP:0012387)1.81013882
96Gangrene (HP:0100758)1.80945947
97Purpura (HP:0000979)1.80726703
98Testicular atrophy (HP:0000029)1.80537063
99Recurrent pneumonia (HP:0006532)1.75227131
100Abnormality of the basal ganglia (HP:0002134)1.74502191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.74848342
2SIK23.46932325
3IRAK12.85360200
4BLK2.50553945
5MAP4K12.36908535
6MAP3K142.33876929
7SIK32.31530364
8MARK32.24016645
9MAP3K132.21851302
10MAP3K22.19376545
11KSR22.15031841
12IRAK22.08368442
13TAOK11.94610632
14IRAK41.93179576
15CHUK1.91671578
16EPHB11.88154740
17MAP3K51.87964986
18IKBKB1.85525768
19TYK21.81749554
20ERN11.78622295
21MAP2K31.78213960
22ACVR1B1.74907098
23IKBKE1.73357528
24EPHA31.73010161
25KSR11.71874171
26AKT31.70033022
27DYRK31.51762299
28SIK11.47943815
29DYRK1B1.47024861
30CDK121.45318821
31MAP3K111.38599014
32FRK1.38493838
33JAK31.37654790
34TBK11.34699167
35TLK11.34572414
36CSK1.33891677
37GRK61.25942748
38TXK1.23516711
39JAK21.21125596
40TNK21.18719742
41MAP3K11.14209675
42HCK1.13282204
43NLK1.13201398
44SYK1.05797570
45MAP3K31.02663115
46PTK61.00130206
47MARK20.95434528
48ZAP700.94418324
49FGR0.92735257
50STK110.92517475
51FER0.92236632
52WNK40.92233380
53RAF10.92179582
54JAK10.91828751
55ARAF0.91018527
56BTK0.89223742
57DAPK20.85322066
58PDK10.85188551
59YES10.83822899
60PDPK10.82889073
61BRAF0.80846367
62TAOK30.80744522
63PIM10.77046973
64KIT0.77014704
65TAOK20.76287846
66WNK10.75317463
67PIK3CG0.75087997
68BMPR20.73127554
69LYN0.72189838
70RPS6KA50.67467156
71FES0.67231633
72PRKAA10.61751595
73ABL20.61280468
74RPS6KA10.61032922
75PKN10.59158774
76FGFR30.57360851
77MATK0.55994944
78DYRK1A0.54624845
79FGFR40.54423982
80TEC0.53622390
81SGK30.51968042
82MAPK110.51241568
83ZAK0.51147551
84CAMK1D0.51058803
85MAP3K80.50372132
86MAP3K90.49740100
87BRD40.48776193
88CDK90.46268580
89BMX0.45653323
90MAP3K70.45349191
91PAK10.44814131
92MAP2K10.43814735
93PRKCZ0.43276195
94MAPK120.42255558
95SGK20.41195076
96LCK0.40419104
97CSF1R0.37379843
98ADRBK20.35713542
99STK40.35663402
100CAMK10.34015041

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.06369287
2Alcoholism_Homo sapiens_hsa050343.36252998
3Staphylococcus aureus infection_Homo sapiens_hsa051502.99312437
4Viral carcinogenesis_Homo sapiens_hsa052032.90424147
5Leishmaniasis_Homo sapiens_hsa051402.53344540
6Osteoclast differentiation_Homo sapiens_hsa043802.48644640
7Allograft rejection_Homo sapiens_hsa053302.33759219
8Graft-versus-host disease_Homo sapiens_hsa053322.33364490
9SNARE interactions in vesicular transport_Homo sapiens_hsa041302.24385511
10Autoimmune thyroid disease_Homo sapiens_hsa053202.05806107
11Primary immunodeficiency_Homo sapiens_hsa053401.97792208
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.86086620
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80455251
14Tuberculosis_Homo sapiens_hsa051521.77739508
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73033231
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69907885
17Type I diabetes mellitus_Homo sapiens_hsa049401.69516415
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.63394338
19B cell receptor signaling pathway_Homo sapiens_hsa046621.61993453
20Herpes simplex infection_Homo sapiens_hsa051681.61218961
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56674010
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55718609
23Malaria_Homo sapiens_hsa051441.53401403
24Antigen processing and presentation_Homo sapiens_hsa046121.50268127
25Legionellosis_Homo sapiens_hsa051341.45707618
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44134332
27Measles_Homo sapiens_hsa051621.43910687
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43216774
29Hematopoietic cell lineage_Homo sapiens_hsa046401.40286028
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.32861104
31Chemokine signaling pathway_Homo sapiens_hsa040621.31545554
32Influenza A_Homo sapiens_hsa051641.27680442
33Acute myeloid leukemia_Homo sapiens_hsa052211.21629273
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16789583
35FoxO signaling pathway_Homo sapiens_hsa040681.15234292
36Toxoplasmosis_Homo sapiens_hsa051451.14792668
37Prolactin signaling pathway_Homo sapiens_hsa049171.14306722
38Phagosome_Homo sapiens_hsa041451.14151541
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12250540
40Viral myocarditis_Homo sapiens_hsa054161.11987635
41African trypanosomiasis_Homo sapiens_hsa051431.10317205
42TNF signaling pathway_Homo sapiens_hsa046681.09138346
43Hepatitis C_Homo sapiens_hsa051601.09061932
44Non-small cell lung cancer_Homo sapiens_hsa052231.03839692
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01516147
46Dorso-ventral axis formation_Homo sapiens_hsa043200.99212917
47Nitrogen metabolism_Homo sapiens_hsa009100.96385215
48Platelet activation_Homo sapiens_hsa046110.94688833
49ABC transporters_Homo sapiens_hsa020100.91979437
50T cell receptor signaling pathway_Homo sapiens_hsa046600.91662166
51Pancreatic cancer_Homo sapiens_hsa052120.81644874
52Shigellosis_Homo sapiens_hsa051310.78610764
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.78554895
54Hepatitis B_Homo sapiens_hsa051610.76615686
55Apoptosis_Homo sapiens_hsa042100.76252221
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75534835
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74401320
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.68966880
59Epstein-Barr virus infection_Homo sapiens_hsa051690.68727770
60Chronic myeloid leukemia_Homo sapiens_hsa052200.68195126
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68153140
62Fatty acid elongation_Homo sapiens_hsa000620.67753078
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.65955130
64Circadian rhythm_Homo sapiens_hsa047100.65906164
65Asthma_Homo sapiens_hsa053100.65207956
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59030526
67Endometrial cancer_Homo sapiens_hsa052130.58337292
68Type II diabetes mellitus_Homo sapiens_hsa049300.58049598
69p53 signaling pathway_Homo sapiens_hsa041150.57084107
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56609799
71Salmonella infection_Homo sapiens_hsa051320.54952127
72Renal cell carcinoma_Homo sapiens_hsa052110.53709280
73Rheumatoid arthritis_Homo sapiens_hsa053230.50740338
74MAPK signaling pathway_Homo sapiens_hsa040100.48379282
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47207050
76Endocytosis_Homo sapiens_hsa041440.45618685
77Bladder cancer_Homo sapiens_hsa052190.43488081
78Choline metabolism in cancer_Homo sapiens_hsa052310.42374481
79Thyroid cancer_Homo sapiens_hsa052160.41374554
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41350036
81Olfactory transduction_Homo sapiens_hsa047400.37845999
82Notch signaling pathway_Homo sapiens_hsa043300.36086702
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33169313
84Pertussis_Homo sapiens_hsa051330.32613796
85Insulin resistance_Homo sapiens_hsa049310.32349147
86HTLV-I infection_Homo sapiens_hsa051660.31788340
87Prostate cancer_Homo sapiens_hsa052150.31627524
88Taste transduction_Homo sapiens_hsa047420.30220841
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29923026
90VEGF signaling pathway_Homo sapiens_hsa043700.28686939
91Complement and coagulation cascades_Homo sapiens_hsa046100.28350230
92Rap1 signaling pathway_Homo sapiens_hsa040150.27856094
93Colorectal cancer_Homo sapiens_hsa052100.27483881
94Insulin signaling pathway_Homo sapiens_hsa049100.26821331
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.26764968
96Serotonergic synapse_Homo sapiens_hsa047260.26608273
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.26011860
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25090690
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23485463
100Long-term depression_Homo sapiens_hsa047300.20268406

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