MICE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)8.18854172
2melanin metabolic process (GO:0006582)7.56724850
3secondary metabolite biosynthetic process (GO:0044550)6.58129061
4regulation of T cell tolerance induction (GO:0002664)5.56624303
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.49064003
6eosinophil chemotaxis (GO:0048245)5.33588585
7positive regulation of tolerance induction (GO:0002645)5.31144561
8regulation of tolerance induction (GO:0002643)4.95455736
9eosinophil migration (GO:0072677)4.70701238
10regulation of regulatory T cell differentiation (GO:0045589)4.63764451
11sphingosine metabolic process (GO:0006670)4.04983442
12regulation of memory T cell differentiation (GO:0043380)4.04248228
13barbed-end actin filament capping (GO:0051016)3.73574634
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73504575
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66159342
16regulation of translational termination (GO:0006449)3.63501089
17positive regulation of T cell mediated cytotoxicity (GO:0001916)3.48605011
18cellular response to thyroid hormone stimulus (GO:0097067)3.47514965
19melanosome organization (GO:0032438)3.43988395
20response to thyroid hormone (GO:0097066)3.42416511
21developmental pigmentation (GO:0048066)3.40637619
22tyrosine metabolic process (GO:0006570)3.33275988
23pigment granule organization (GO:0048753)3.31684482
24response to muscle activity (GO:0014850)3.28748193
25cellular response to ethanol (GO:0071361)3.27602042
26pyrimidine-containing compound salvage (GO:0008655)3.27530130
27pyrimidine nucleoside salvage (GO:0043097)3.27530130
28antigen processing and presentation of endogenous antigen (GO:0019883)3.24289809
29diol metabolic process (GO:0034311)3.21646546
30negative regulation of defense response to virus (GO:0050687)3.20883849
31response to type I interferon (GO:0034340)3.18896032
32regulation of lymphocyte chemotaxis (GO:1901623)3.18144214
33negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.16475565
34proteasome assembly (GO:0043248)3.15603582
35cellular response to type I interferon (GO:0071357)3.11663330
36type I interferon signaling pathway (GO:0060337)3.11663330
37regulation of T cell mediated cytotoxicity (GO:0001914)3.07009934
38pigment biosynthetic process (GO:0046148)3.02707690
39negative regulation of viral entry into host cell (GO:0046597)2.95297129
40negative regulation of response to biotic stimulus (GO:0002832)2.95217819
41positive regulation of lymphocyte migration (GO:2000403)2.90260960
42positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79364078
43hyaluronan catabolic process (GO:0030214)2.77839818
44sphingoid metabolic process (GO:0046519)2.77465018
45mRNA cleavage (GO:0006379)2.76112331
46necroptotic process (GO:0070266)2.72703972
47pigment metabolic process (GO:0042440)2.72403446
48regulation of superoxide anion generation (GO:0032928)2.71798748
49mitotic G2 DNA damage checkpoint (GO:0007095)2.68899885
50regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.68842569
51regulation of lymphocyte migration (GO:2000401)2.62891047
52regulation of oxidative phosphorylation (GO:0002082)2.58389791
53positive regulation of Cdc42 GTPase activity (GO:0043089)2.56548898
54negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.54457839
55regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.53837158
56hypotonic response (GO:0006971)2.52832605
57regulation of acyl-CoA biosynthetic process (GO:0050812)2.50987884
58negative regulation of interleukin-12 production (GO:0032695)2.47037261
59regulation of hydrogen peroxide metabolic process (GO:0010310)2.46924551
60mitotic G2/M transition checkpoint (GO:0044818)2.43417267
61immunoglobulin mediated immune response (GO:0016064)2.40526664
62phenol-containing compound biosynthetic process (GO:0046189)2.39173375
63positive regulation of cAMP-mediated signaling (GO:0043950)2.38214254
64regulation of superoxide metabolic process (GO:0090322)2.38030224
65negative regulation of organelle assembly (GO:1902116)2.36703329
66regulation of macrophage chemotaxis (GO:0010758)2.36147298
67coenzyme catabolic process (GO:0009109)2.34970752
68positive regulation of natural killer cell activation (GO:0032816)2.32576786
69B cell mediated immunity (GO:0019724)2.32004001
70positive regulation of interleukin-12 production (GO:0032735)2.30525932
71regulation of coenzyme metabolic process (GO:0051196)2.28335707
72regulation of cofactor metabolic process (GO:0051193)2.28335707
73galactose metabolic process (GO:0006012)2.26512731
74response to peptidoglycan (GO:0032494)2.25750084
75detection of molecule of bacterial origin (GO:0032490)2.24168847
76pigment cell differentiation (GO:0050931)2.22043719
77T cell migration (GO:0072678)2.21657081
78negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.21528853
79mast cell activation (GO:0045576)2.19633562
80regulation of viral entry into host cell (GO:0046596)2.19365046
81interferon-gamma-mediated signaling pathway (GO:0060333)2.19339532
82regulation of mononuclear cell migration (GO:0071675)2.19004132
83positive regulation of gamma-delta T cell activation (GO:0046645)2.18417908
84AMP metabolic process (GO:0046033)2.15670260
85regulation of interleukin-12 production (GO:0032655)2.14292654
86nucleoside salvage (GO:0043174)2.13598441
87nucleobase-containing small molecule interconversion (GO:0015949)2.12873753
88positive regulation of T cell mediated immunity (GO:0002711)2.12690611
89regulation of sulfur metabolic process (GO:0042762)2.12438623
90phagocytosis, recognition (GO:0006910)2.12045069
91response to interferon-alpha (GO:0035455)2.11878147
92melanocyte differentiation (GO:0030318)2.10110838
93cofactor catabolic process (GO:0051187)2.09356539
94oxaloacetate metabolic process (GO:0006107)2.08730425
95response to protozoan (GO:0001562)2.08044201
96positive regulation of T cell migration (GO:2000406)2.07809076
97regulation of T cell migration (GO:2000404)2.06912476
98TOR signaling (GO:0031929)2.06711087
99mitotic chromosome condensation (GO:0007076)2.06181202
100antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.04678534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.98547645
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.47858940
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.41286310
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.52945904
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.10121493
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.87606905
7GATA1_22025678_ChIP-Seq_K562_Human2.54779598
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.49739471
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.48421804
10TFEB_21752829_ChIP-Seq_HELA_Human2.23455539
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20468095
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07732443
13STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86847035
14AR_21909140_ChIP-Seq_LNCAP_Human1.82812535
15MYB_21317192_ChIP-Seq_ERMYB_Mouse1.81270908
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76098453
17EGR1_23403033_ChIP-Seq_LIVER_Mouse1.73020639
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68390269
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68159647
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68144415
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65400248
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63123805
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61932091
24MYB_26560356_Chip-Seq_TH1_Human1.52566660
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50322564
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49054659
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48124720
28SPI1_23547873_ChIP-Seq_NB4_Human1.47553218
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47470386
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46640500
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.45931500
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44955338
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42563524
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.39162130
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37637744
36MYB_26560356_Chip-Seq_TH2_Human1.37466716
37CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35496747
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33260916
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32787031
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32282142
41DCP1A_22483619_ChIP-Seq_HELA_Human1.32019408
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27441218
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26778436
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26202428
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25172656
46SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25172656
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24834433
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23274419
49FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22602415
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22048171
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21424631
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19765642
53SPI1_23127762_ChIP-Seq_K562_Human1.18544511
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16418508
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.15834721
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14292462
57HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14184699
58ZNF263_19887448_ChIP-Seq_K562_Human1.08260681
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06753570
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.05984571
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05836045
62FOXP3_21729870_ChIP-Seq_TREG_Human1.05740454
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03889623
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01608690
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.01556860
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.00255162
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00219816
68VDR_24787735_ChIP-Seq_THP-1_Human0.99089778
69MAF_26560356_Chip-Seq_TH2_Human0.98911454
70RXR_22158963_ChIP-Seq_LIVER_Mouse0.98658346
71PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97545669
72GABP_17652178_ChIP-ChIP_JURKAT_Human0.97376203
73RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96025934
74HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95646334
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95602106
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93813233
77ELK1_19687146_ChIP-ChIP_HELA_Human0.91632853
78JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91169926
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89986390
80GATA6_25053715_ChIP-Seq_YYC3_Human0.89935438
81NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89620290
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89239966
83PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88288560
84SMAD_19615063_ChIP-ChIP_OVARY_Human0.87253393
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87192727
86VDR_24763502_ChIP-Seq_THP-1_Human0.86642149
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86489478
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84755727
89EST1_17652178_ChIP-ChIP_JURKAT_Human0.84724996
90MAF_26560356_Chip-Seq_TH1_Human0.84392523
91GATA3_26560356_Chip-Seq_TH2_Human0.83965906
92NCOR1_26117541_ChIP-Seq_K562_Human0.83737001
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83719187
94GATA1_19941826_ChIP-Seq_K562_Human0.83704968
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83368870
96NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83113170
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81932349
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80903977
99ETS1_20019798_ChIP-Seq_JURKAT_Human0.80197942
100PU_27001747_Chip-Seq_BMDM_Mouse0.78643353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation6.16041812
2MP0005408_hypopigmentation4.43807788
3MP0005171_absent_coat_pigmentation4.24812342
4MP0003136_yellow_coat_color4.11628755
5MP0004381_abnormal_hair_follicle3.91513603
6MP0005075_abnormal_melanosome_morpholog3.77222195
7MP0000015_abnormal_ear_pigmentation3.59158863
8MP0003806_abnormal_nucleotide_metabolis3.37041269
9MP0002877_abnormal_melanocyte_morpholog3.05961880
10MP0000371_diluted_coat_color2.63978409
11MP0005174_abnormal_tail_pigmentation2.49929517
12MP0002095_abnormal_skin_pigmentation2.18791119
13MP0001835_abnormal_antigen_presentation1.85273004
14MP0003172_abnormal_lysosome_physiology1.82152492
15MP0005058_abnormal_lysosome_morphology1.74421180
16MP0003646_muscle_fatigue1.64089914
17MP0002090_abnormal_vision1.59411382
18MP0004233_abnormal_muscle_weight1.58247989
19MP0002148_abnormal_hypersensitivity_rea1.56935180
20MP0000569_abnormal_digit_pigmentation1.54176520
21MP0005671_abnormal_response_to1.49511969
22MP0003950_abnormal_plasma_membrane1.49501861
23MP0005451_abnormal_body_composition1.45722845
24MP0002075_abnormal_coat/hair_pigmentati1.45577067
25MP0001324_abnormal_eye_pigmentation1.43227873
26MP0003763_abnormal_thymus_physiology1.41896841
27MP0009785_altered_susceptibility_to1.39976181
28MP0003186_abnormal_redox_activity1.38215875
29MP0000749_muscle_degeneration1.36209178
30MP0001851_eye_inflammation1.35472122
31MP0003195_calcinosis1.33326757
32MP0010094_abnormal_chromosome_stability1.32206424
33MP0009840_abnormal_foam_cell1.27055512
34MP0009333_abnormal_splenocyte_physiolog1.25783696
35MP0001186_pigmentation_phenotype1.25059892
36MP0002132_abnormal_respiratory_system1.24288603
37MP0004084_abnormal_cardiac_muscle1.23248152
38MP0005387_immune_system_phenotype1.22871670
39MP0001790_abnormal_immune_system1.22871670
40MP0003111_abnormal_nucleus_morphology1.19432776
41MP0002419_abnormal_innate_immunity1.17903244
42MP0000343_altered_response_to1.16607033
43MP0002837_dystrophic_cardiac_calcinosis1.15820164
44MP0000685_abnormal_immune_system1.13962576
45MP0003693_abnormal_embryo_hatching1.13076131
46MP0002452_abnormal_antigen_presenting1.12968667
47MP0010234_abnormal_vibrissa_follicle1.12691463
48MP0003191_abnormal_cellular_cholesterol1.12298609
49MP0005257_abnormal_intraocular_pressure1.11958844
50MP0001800_abnormal_humoral_immune1.11932999
51MP0002102_abnormal_ear_morphology1.11688818
52MP0006082_CNS_inflammation1.11231727
53MP0004272_abnormal_basement_membrane1.09284576
54MP0009697_abnormal_copulation1.09085899
55MP0005000_abnormal_immune_tolerance1.08284487
56MP0005025_abnormal_response_to1.07805708
57MP0005464_abnormal_platelet_physiology1.04729912
58MP0002723_abnormal_immune_serum1.02032378
59MP0003656_abnormal_erythrocyte_physiolo0.97696069
60MP0002420_abnormal_adaptive_immunity0.97544592
61MP0001819_abnormal_immune_cell0.97292633
62MP0005360_urolithiasis0.95925492
63MP0006036_abnormal_mitochondrial_physio0.92481552
64MP0003077_abnormal_cell_cycle0.89565530
65MP0001661_extended_life_span0.89555176
66MP0005670_abnormal_white_adipose0.88832184
67MP0008057_abnormal_DNA_replication0.87253342
68MP0005330_cardiomyopathy0.86851822
69MP0001845_abnormal_inflammatory_respons0.85901181
70MP0003878_abnormal_ear_physiology0.83762644
71MP0005377_hearing/vestibular/ear_phenot0.83762644
72MP0002269_muscular_atrophy0.82600952
73MP0005197_abnormal_uvea_morphology0.81805159
74MP0004484_altered_response_of0.78952876
75MP0000678_abnormal_parathyroid_gland0.77659039
76MP0002998_abnormal_bone_remodeling0.77560800
77MP0002398_abnormal_bone_marrow0.74609230
78MP0003045_fibrosis0.73981483
79MP0004036_abnormal_muscle_relaxation0.73582359
80MP0000716_abnormal_immune_system0.73341176
81MP0003786_premature_aging0.73211565
82MP0008058_abnormal_DNA_repair0.72401250
83MP0005164_abnormal_response_to0.71572521
84MP0002405_respiratory_system_inflammati0.70370048
85MP0000920_abnormal_myelination0.70251322
86MP0002722_abnormal_immune_system0.67400130
87MP0002396_abnormal_hematopoietic_system0.66883815
88MP0008469_abnormal_protein_level0.66734457
89MP0002429_abnormal_blood_cell0.66429679
90MP0004957_abnormal_blastocyst_morpholog0.65920789
91MP0003436_decreased_susceptibility_to0.65821674
92MP0002139_abnormal_hepatobiliary_system0.65707465
93MP0008007_abnormal_cellular_replicative0.65577320
94MP0000689_abnormal_spleen_morphology0.64084309
95MP0008260_abnormal_autophagy0.60426889
96MP0003315_abnormal_perineum_morphology0.60024814
97MP0000703_abnormal_thymus_morphology0.60009525
98MP0009764_decreased_sensitivity_to0.59727301
99MP0004264_abnormal_extraembryonic_tissu0.59352288
100MP0009763_increased_sensitivity_to0.58480856

Predicted human phenotypes

RankGene SetZ-score
1Ocular albinism (HP:0001107)5.79802327
2Aplasia/Hypoplasia of the macula (HP:0008059)4.84207874
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.82830482
4Abnormality of glycolipid metabolism (HP:0010969)4.82830482
5Abnormality of liposaccharide metabolism (HP:0010968)4.82830482
6Iris hypopigmentation (HP:0007730)4.77079604
7Aplasia/Hypoplasia affecting the retina (HP:0008061)4.43361964
8Albinism (HP:0001022)4.20162942
9Cutaneous melanoma (HP:0012056)4.15246374
10Aplasia/Hypoplasia of the fovea (HP:0008060)3.82532507
11Hypoplasia of the fovea (HP:0007750)3.82532507
12Pustule (HP:0200039)3.80415670
13Cholecystitis (HP:0001082)3.79378317
14Abnormal gallbladder physiology (HP:0012438)3.79378317
15Blue irides (HP:0000635)3.61184214
16Generalized hypopigmentation (HP:0007513)3.58791878
17White forelock (HP:0002211)3.42112963
18Poor head control (HP:0002421)3.25592821
19Patchy hypopigmentation of hair (HP:0011365)3.25419346
20Abnormality of the fovea (HP:0000493)3.22922897
21Freckling (HP:0001480)3.08971522
22Glomerulonephritis (HP:0000099)2.82234099
23Abnormal auditory evoked potentials (HP:0006958)2.77389984
24Hypopigmentation of the fundus (HP:0007894)2.67389087
25Premature graying of hair (HP:0002216)2.64471734
26Systemic lupus erythematosus (HP:0002725)2.63465595
27Vascular calcification (HP:0004934)2.51779238
28Horizontal nystagmus (HP:0000666)2.51644912
29Hyporeflexia of lower limbs (HP:0002600)2.47168340
30Myocardial infarction (HP:0001658)2.43644327
31Squamous cell carcinoma (HP:0002860)2.34721069
32Right ventricular cardiomyopathy (HP:0011663)2.34686219
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.32035493
34Abnormality of glycolysis (HP:0004366)2.25824912
35Recurrent bacterial skin infections (HP:0005406)2.23602539
36Autoimmune hemolytic anemia (HP:0001890)2.20621537
37Recurrent abscess formation (HP:0002722)2.19366011
38Pulmonary infiltrates (HP:0002113)2.18030231
39Colitis (HP:0002583)2.17923962
40Vacuolated lymphocytes (HP:0001922)2.17505162
41Chromsome breakage (HP:0040012)2.17234426
42Cardiovascular calcification (HP:0011915)2.16784798
43Reduced antithrombin III activity (HP:0001976)2.12455878
44Retrobulbar optic neuritis (HP:0100654)2.09826422
45Optic neuritis (HP:0100653)2.09826422
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06504309
47Granulocytopenia (HP:0001913)2.04908712
48Congenital stationary night blindness (HP:0007642)2.03823034
49Orchitis (HP:0100796)1.99109599
50Entropion (HP:0000621)1.97689968
51Onycholysis (HP:0001806)1.95459665
52Generalized hypopigmentation of hair (HP:0011358)1.95418269
53Prolonged partial thromboplastin time (HP:0003645)1.95216758
54Abnormality of the preputium (HP:0100587)1.94294049
55Enlarged kidneys (HP:0000105)1.92955776
56T lymphocytopenia (HP:0005403)1.91235751
57Aplasia cutis congenita (HP:0001057)1.89777730
58Abnormality of T cell number (HP:0011839)1.89541235
59Segmental peripheral demyelination/remyelination (HP:0003481)1.89387188
60Keratoconjunctivitis sicca (HP:0001097)1.85971687
61Osteolytic defects of the hand bones (HP:0009699)1.84128957
62Osteolytic defects of the phalanges of the hand (HP:0009771)1.84128957
63Ileus (HP:0002595)1.83033494
64Poikiloderma (HP:0001029)1.81637931
65Centrally nucleated skeletal muscle fibers (HP:0003687)1.81345422
66Dysostosis multiplex (HP:0000943)1.81013027
67Pancreatic islet-cell hyperplasia (HP:0004510)1.80919387
68Increased serum pyruvate (HP:0003542)1.80815225
69Melanoma (HP:0002861)1.79254364
70Eosinophilia (HP:0001880)1.79012798
71Fatigue (HP:0012378)1.78395390
72Hypoplasia of the iris (HP:0007676)1.76888943
73Decreased central vision (HP:0007663)1.74742265
74Abnormal platelet function (HP:0011869)1.73748485
75Impaired platelet aggregation (HP:0003540)1.73748485
76Nonimmune hydrops fetalis (HP:0001790)1.73586485
77Abnormality of macrophages (HP:0004311)1.71952241
78Abnormality of the alveolar ridges (HP:0006477)1.71537947
79Joint hemorrhage (HP:0005261)1.71531722
80Cholelithiasis (HP:0001081)1.68906732
81Chronic mucocutaneous candidiasis (HP:0002728)1.68484423
82Recurrent cutaneous fungal infections (HP:0011370)1.68484423
83Bilateral sensorineural hearing impairment (HP:0008619)1.67812110
84Polycythemia (HP:0001901)1.67809664
85Abnormality of the ileum (HP:0001549)1.66146325
86Recurrent skin infections (HP:0001581)1.66016397
87Myositis (HP:0100614)1.64592014
88Birth length less than 3rd percentile (HP:0003561)1.63936359
89Lower limb hyperreflexia (HP:0002395)1.62236514
90Slow saccadic eye movements (HP:0000514)1.62127570
91Abnormality of polysaccharide metabolism (HP:0011012)1.61790327
92Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61790327
93Abnormality of mucopolysaccharide metabolism (HP:0011020)1.61790327
94Axonal loss (HP:0003447)1.60785374
95Abnormality of the intrinsic pathway (HP:0010989)1.60773348
96Abnormality of T cells (HP:0002843)1.60684417
97Abnormality of chromosome stability (HP:0003220)1.60081883
98Thyroid-stimulating hormone excess (HP:0002925)1.59233366
99Gangrene (HP:0100758)1.59095700
100Congenital ichthyosiform erythroderma (HP:0007431)1.58652470

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK34.09145085
2BLK3.51024332
3MAP3K33.38396688
4WEE12.96510333
5LATS12.92047711
6BRSK12.77262738
7NEK22.74863503
8SIK32.59853384
9PINK12.59175430
10MST1R2.56734662
11NME22.40384190
12LATS22.09233155
13EIF2AK31.86648736
14WNK41.83594048
15EIF2AK11.74157535
16BUB11.62406238
17IRAK31.60995682
18MELK1.53502542
19BRSK21.45046291
20TYK21.44969394
21TXK1.44763463
22ADRBK21.39708319
23STK391.34004599
24MYLK1.33950398
25TAOK31.30891021
26MAPK111.24074118
27PBK1.23059643
28KSR11.20456409
29TRIM281.18480979
30MAP4K11.18101047
31CCNB11.17832542
32STK38L1.16735637
33PDK21.16267561
34MAP3K141.14837261
35STK31.14391568
36ZAP701.11928286
37GRK61.11726585
38CLK11.08975168
39STK381.06825807
40WNK11.05251256
41TGFBR21.03945028
42MAP3K21.03397293
43FGR0.94713968
44PTK2B0.93543961
45ERN10.89116389
46JAK10.88174492
47MAP3K10.87858781
48TRPM70.87654451
49MAP3K80.84563653
50STK100.83994825
51MAP3K130.81872558
52ACVR1B0.79152521
53IRAK20.77539744
54BMPR20.76881016
55IKBKE0.76602512
56PRPF4B0.76202195
57CDC42BPA0.72286875
58BTK0.71928429
59STK40.71872638
60JAK30.71752996
61PAK40.70692488
62PRKCQ0.68771991
63BCR0.66040038
64TBK10.64655931
65CDK30.63629323
66OBSCN0.63266054
67FGFR40.62816583
68TTK0.60548599
69TAOK20.56485578
70ARAF0.54607963
71MST40.53399425
72BMPR1B0.52267072
73CDK70.48898027
74SYK0.48659291
75MET0.48258830
76AURKB0.47621032
77MAP2K30.47485821
78IKBKB0.47437390
79RIPK40.46661569
80MAPKAPK20.46650426
81PIK3CG0.46364180
82FER0.45038768
83CDC70.44652352
84CSNK1A1L0.43141868
85LYN0.42720771
86FGFR30.42265650
87KSR20.41720861
88AKT20.41107990
89CSK0.40225804
90MUSK0.37719008
91PIM10.37501896
92MAPKAPK30.36828755
93NLK0.35874464
94ATR0.35520376
95PLK10.35169517
96EGFR0.34692884
97ATM0.34514555
98IGF1R0.34096618
99EIF2AK20.33648895
100PRKAA20.29950599

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31331946
2Graft-versus-host disease_Homo sapiens_hsa053323.12880383
3Allograft rejection_Homo sapiens_hsa053303.06043945
4Autoimmune thyroid disease_Homo sapiens_hsa053202.89055263
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.66450583
6Staphylococcus aureus infection_Homo sapiens_hsa051502.59844424
7Other glycan degradation_Homo sapiens_hsa005112.58773845
8Viral myocarditis_Homo sapiens_hsa054162.18155054
9Proteasome_Homo sapiens_hsa030502.08716733
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.03207473
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.01005446
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95593845
13Non-homologous end-joining_Homo sapiens_hsa034501.85264821
14Type I diabetes mellitus_Homo sapiens_hsa049401.85154633
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.71947755
16Antigen processing and presentation_Homo sapiens_hsa046121.64402677
17Sphingolipid metabolism_Homo sapiens_hsa006001.60672471
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58484705
19Herpes simplex infection_Homo sapiens_hsa051681.52802447
20Lysosome_Homo sapiens_hsa041421.51010959
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50135925
22Tyrosine metabolism_Homo sapiens_hsa003501.47451707
23Asthma_Homo sapiens_hsa053101.43528317
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42424240
25Complement and coagulation cascades_Homo sapiens_hsa046101.36510667
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.34798264
27DNA replication_Homo sapiens_hsa030301.26448232
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25904266
29Homologous recombination_Homo sapiens_hsa034401.19878461
30Phagosome_Homo sapiens_hsa041451.17754602
31Glutathione metabolism_Homo sapiens_hsa004801.17727185
32Measles_Homo sapiens_hsa051621.16615103
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16400196
34Rheumatoid arthritis_Homo sapiens_hsa053231.15763667
35Pentose phosphate pathway_Homo sapiens_hsa000301.14578100
36Influenza A_Homo sapiens_hsa051641.11101650
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08825867
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07068888
39Leishmaniasis_Homo sapiens_hsa051401.06948319
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05774518
41One carbon pool by folate_Homo sapiens_hsa006701.04920552
42Osteoclast differentiation_Homo sapiens_hsa043801.04211367
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04055115
44Apoptosis_Homo sapiens_hsa042101.02906859
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01131022
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98873813
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98364717
48Tuberculosis_Homo sapiens_hsa051520.98353362
49Primary immunodeficiency_Homo sapiens_hsa053400.96372877
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.93512356
51Galactose metabolism_Homo sapiens_hsa000520.91102635
52Hematopoietic cell lineage_Homo sapiens_hsa046400.89885138
53Fructose and mannose metabolism_Homo sapiens_hsa000510.89559519
54Systemic lupus erythematosus_Homo sapiens_hsa053220.89243617
55Legionellosis_Homo sapiens_hsa051340.88809620
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87458977
57Toxoplasmosis_Homo sapiens_hsa051450.79823508
58Malaria_Homo sapiens_hsa051440.78431857
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.76414158
60Cell cycle_Homo sapiens_hsa041100.74950275
61Small cell lung cancer_Homo sapiens_hsa052220.74055734
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72186039
63Epstein-Barr virus infection_Homo sapiens_hsa051690.69994051
64TNF signaling pathway_Homo sapiens_hsa046680.69740452
65p53 signaling pathway_Homo sapiens_hsa041150.69672162
66Pyrimidine metabolism_Homo sapiens_hsa002400.68629138
67B cell receptor signaling pathway_Homo sapiens_hsa046620.67696544
68Pyruvate metabolism_Homo sapiens_hsa006200.66396278
69Viral carcinogenesis_Homo sapiens_hsa052030.64902443
70Phenylalanine metabolism_Homo sapiens_hsa003600.61675671
71Fanconi anemia pathway_Homo sapiens_hsa034600.59747731
72Hepatitis B_Homo sapiens_hsa051610.59683067
73Basal transcription factors_Homo sapiens_hsa030220.57405677
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56294051
75Mismatch repair_Homo sapiens_hsa034300.53826005
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53601056
77Acute myeloid leukemia_Homo sapiens_hsa052210.52821741
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52551152
79Starch and sucrose metabolism_Homo sapiens_hsa005000.51666742
80N-Glycan biosynthesis_Homo sapiens_hsa005100.50118096
81HTLV-I infection_Homo sapiens_hsa051660.48250840
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.47530559
83Carbon metabolism_Homo sapiens_hsa012000.46128968
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45844467
85Chemokine signaling pathway_Homo sapiens_hsa040620.44810625
86Non-small cell lung cancer_Homo sapiens_hsa052230.43644715
87Base excision repair_Homo sapiens_hsa034100.43182573
88Thyroid cancer_Homo sapiens_hsa052160.42606806
89Hepatitis C_Homo sapiens_hsa051600.41425496
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40758438
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40616577
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36368019
93Pertussis_Homo sapiens_hsa051330.35323096
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34669282
95Pancreatic cancer_Homo sapiens_hsa052120.34302831
96Nucleotide excision repair_Homo sapiens_hsa034200.33941994
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33113246
98Prostate cancer_Homo sapiens_hsa052150.32450418
99Shigellosis_Homo sapiens_hsa051310.30537931
100Olfactory transduction_Homo sapiens_hsa047400.29998411

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »