MICU1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1barbed-end actin filament capping (GO:0051016)4.16218367
2negative regulation of protein localization to cell surface (GO:2000009)4.00699997
3positive regulation of osteoblast proliferation (GO:0033690)3.85641993
4cellular response to thyroid hormone stimulus (GO:0097067)3.69877982
5regulation of integrin-mediated signaling pathway (GO:2001044)3.60377982
6response to thyroid hormone (GO:0097066)3.51377356
7glutamate secretion (GO:0014047)3.51186195
8synaptic vesicle maturation (GO:0016188)3.48906034
9protein neddylation (GO:0045116)3.47363440
10negative regulation of protein localization to plasma membrane (GO:1903077)3.47115547
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.46604369
12L-phenylalanine metabolic process (GO:0006558)3.46604369
13platelet aggregation (GO:0070527)3.43662445
14synaptic vesicle docking involved in exocytosis (GO:0016081)3.42949665
15synaptic vesicle exocytosis (GO:0016079)3.40545474
16positive regulation of receptor recycling (GO:0001921)3.33086896
17regulation of receptor recycling (GO:0001919)3.24357996
18L-phenylalanine catabolic process (GO:0006559)3.22404731
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.22404731
20regulation of synapse structural plasticity (GO:0051823)3.21565635
21regulation of short-term neuronal synaptic plasticity (GO:0048172)3.20535221
22positive regulation of vesicle fusion (GO:0031340)3.19515186
23regulation of synaptic vesicle exocytosis (GO:2000300)3.18444246
24cellular potassium ion homeostasis (GO:0030007)3.10285152
25erythrocyte development (GO:0048821)3.09895251
26beta-amyloid metabolic process (GO:0050435)3.06248909
27glycosphingolipid catabolic process (GO:0046479)2.97085426
28positive regulation of insulin receptor signaling pathway (GO:0046628)2.93180002
29protoporphyrinogen IX metabolic process (GO:0046501)2.92251038
30locomotory exploration behavior (GO:0035641)2.92133120
31regulation of vesicle fusion (GO:0031338)2.89583812
32vocalization behavior (GO:0071625)2.88878788
33neuronal action potential propagation (GO:0019227)2.86096492
34positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85916302
35postsynaptic membrane organization (GO:0001941)2.85751947
36oligosaccharide catabolic process (GO:0009313)2.85659175
37membrane invagination (GO:0010324)2.82219789
38negative regulation of dendrite morphogenesis (GO:0050774)2.81910359
39* positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.81058781
40clathrin coat assembly (GO:0048268)2.78794255
41energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.78776904
42ATP hydrolysis coupled proton transport (GO:0015991)2.78776904
43vesicle docking involved in exocytosis (GO:0006904)2.78615522
44regulation of synaptic vesicle transport (GO:1902803)2.78253187
45tricarboxylic acid cycle (GO:0006099)2.71693071
46negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.71134131
47regulation of platelet aggregation (GO:0090330)2.70284698
48neurotransmitter secretion (GO:0007269)2.69497567
49adenosine receptor signaling pathway (GO:0001973)2.69316500
50positive regulation of neurotransmitter secretion (GO:0001956)2.66758985
51* mitochondrial calcium ion transport (GO:0006851)2.66612702
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65220360
53granulocyte differentiation (GO:0030851)2.63754105
54blood coagulation, intrinsic pathway (GO:0007597)2.63360723
55negative regulation of bone mineralization (GO:0030502)2.62699958
56long-term synaptic potentiation (GO:0060291)2.61602453
57regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.61149875
58regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.60996404
59positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.59839539
60neutrophil activation involved in immune response (GO:0002283)2.59093273
61negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.57885044
62glycolipid catabolic process (GO:0019377)2.57240852
63deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56900999
64platelet degranulation (GO:0002576)2.56569233
65phagosome maturation (GO:0090382)2.55549974
66gamma-aminobutyric acid transport (GO:0015812)2.52686195
67* mitochondrial calcium ion homeostasis (GO:0051560)2.52630787
68regulation of oxidative phosphorylation (GO:0002082)2.50028391
69response to auditory stimulus (GO:0010996)2.48230380
70neurotransmitter catabolic process (GO:0042135)2.47842120
71vesicle docking (GO:0048278)2.47389027
72substantia nigra development (GO:0021762)2.47251509
73succinate metabolic process (GO:0006105)2.47139913
74regulation of voltage-gated calcium channel activity (GO:1901385)2.46905706
75virion attachment to host cell (GO:0019062)2.42185372
76adhesion of symbiont to host cell (GO:0044650)2.42185372
77triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.42122767
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.40345962
79ceramide catabolic process (GO:0046514)2.40078314
80fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.38823318
81regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.37818255
82negative regulation of biomineral tissue development (GO:0070168)2.37248434
83regulation of protein localization to cell surface (GO:2000008)2.36566904
84regulation of early endosome to late endosome transport (GO:2000641)2.36337376
85sodium ion export (GO:0071436)2.35613171
86regulation of metalloenzyme activity (GO:0048552)2.35346765
87neurotransmitter-gated ion channel clustering (GO:0072578)2.34437505
88response to methylmercury (GO:0051597)2.34176599
89negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.34096060
90positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.33611886
91regulation of protein targeting to membrane (GO:0090313)2.33561552
92negative regulation of dendrite development (GO:2000171)2.33138507
93protein targeting to plasma membrane (GO:0072661)2.32781294
94regulation of vacuole organization (GO:0044088)2.32482526
95negative regulation of receptor-mediated endocytosis (GO:0048261)2.31235522
96macroautophagy (GO:0016236)2.30940488
97iron ion transport (GO:0006826)2.30866886
98regulation of neuronal synaptic plasticity (GO:0048168)2.28822066
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.28643260
100valine metabolic process (GO:0006573)2.28425348
101regulation of cAMP-dependent protein kinase activity (GO:2000479)2.28295614
102peptidyl-cysteine modification (GO:0018198)2.28012081
103COPI coating of Golgi vesicle (GO:0048205)2.27310678
104Golgi transport vesicle coating (GO:0048200)2.27310678
105transferrin transport (GO:0033572)2.27088319
106innervation (GO:0060384)2.26591000
107positive regulation of cellular response to insulin stimulus (GO:1900078)2.26379927
108positive regulation of glycolytic process (GO:0045821)2.25876922
109negative regulation of JAK-STAT cascade (GO:0046426)2.25835706
110exploration behavior (GO:0035640)2.24386076
111regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.24313661
112glycine transport (GO:0015816)2.23161737
113nuclear envelope reassembly (GO:0031468)2.21967215
114mitotic nuclear envelope reassembly (GO:0007084)2.21967215
115peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.21870058
116relaxation of smooth muscle (GO:0044557)2.21718563
117alpha-linolenic acid metabolic process (GO:0036109)2.20809679
118membrane depolarization during action potential (GO:0086010)2.19894296
119cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.19735004
120positive regulation of synapse maturation (GO:0090129)2.19716477
121platelet formation (GO:0030220)2.18229367
122peroxisome fission (GO:0016559)2.18222268
123positive regulation of neurotransmitter transport (GO:0051590)2.17977355
124activation of protein kinase A activity (GO:0034199)2.17924592
125regulation of glutamate receptor signaling pathway (GO:1900449)2.17641701
126plasma membrane repair (GO:0001778)2.17490443
127ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.17278584
128oxaloacetate metabolic process (GO:0006107)2.17256120
129negative regulation of heart rate (GO:0010459)2.17135235
130glomerular epithelial cell development (GO:0072310)2.16512713
131glomerular visceral epithelial cell development (GO:0072015)2.16444107
132ferric iron transport (GO:0015682)2.15475427
133trivalent inorganic cation transport (GO:0072512)2.15475427
134regulation of neurotransmitter uptake (GO:0051580)2.15055694
135actin filament depolymerization (GO:0030042)2.14587177
136adhesion of symbiont to host (GO:0044406)2.13011921
137regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.12912844
138regulation of amyloid precursor protein catabolic process (GO:1902991)2.12550163
139regulation of long-term neuronal synaptic plasticity (GO:0048169)2.12320212
140response to gravity (GO:0009629)2.11616839
141regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.11375993
142membrane hyperpolarization (GO:0060081)2.11328859
143prepulse inhibition (GO:0060134)2.10047247
144regulation of neurotransmitter transport (GO:0051588)2.09781909
145negative regulation of cation channel activity (GO:2001258)2.09581674
146regulation of sodium ion transmembrane transporter activity (GO:2000649)2.09271529
147regulation of synaptic plasticity (GO:0048167)2.08504253
148regulation of neurotransmitter secretion (GO:0046928)2.07790056
149striatum development (GO:0021756)2.07726117
150positive regulation of synaptic transmission (GO:0050806)2.05826039
151neuromuscular process controlling balance (GO:0050885)2.05563087
152regulation of synaptic transmission, glutamatergic (GO:0051966)2.05015399
153synaptic vesicle endocytosis (GO:0048488)2.04886876
154neurotransmitter transport (GO:0006836)2.03474086
155regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.02793540
156proline transport (GO:0015824)2.02348898
157regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.01607788
158regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.01607788
159negative regulation of synaptic transmission, GABAergic (GO:0032229)2.01406890
160potassium ion homeostasis (GO:0055075)2.00919955
161fatty acid elongation (GO:0030497)2.00889119
162behavioral response to cocaine (GO:0048148)2.00755624
163neuromuscular synaptic transmission (GO:0007274)2.00437974
164neuron cell-cell adhesion (GO:0007158)1.99945613
165dopamine receptor signaling pathway (GO:0007212)1.98874898
166dendrite morphogenesis (GO:0048813)1.97686746
167neuron-neuron synaptic transmission (GO:0007270)1.97375102
168positive regulation of axon extension (GO:0045773)1.97335014
169auditory behavior (GO:0031223)1.96296346
170L-glutamate transport (GO:0015813)1.95932030
171regulation of beta-amyloid formation (GO:1902003)1.95718414
172cytoskeletal anchoring at plasma membrane (GO:0007016)1.95413795
173angiotensin maturation (GO:0002003)1.94693872
174protein localization to synapse (GO:0035418)1.94232245
175acidic amino acid transport (GO:0015800)1.91830709
176chemosensory behavior (GO:0007635)1.91774810
177phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)1.91169649
178regulation of neurotransmitter levels (GO:0001505)1.90731645
179neuron projection extension involved in neuron projection guidance (GO:1902284)1.89935742
180axon extension involved in axon guidance (GO:0048846)1.89935742
181positive regulation of p38MAPK cascade (GO:1900745)1.89888466
182negative regulation of sodium ion transport (GO:0010766)1.89086301
183axonal fasciculation (GO:0007413)1.88860836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.19588088
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.04129079
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.79915642
4GATA1_19941826_ChIP-Seq_K562_Human2.69707865
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.47925365
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46093605
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.45240095
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40083773
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.22576027
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15064849
11EOMES_21245162_ChIP-Seq_HESCs_Human2.12778034
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09186459
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08656213
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07001889
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07001889
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06556107
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05078678
18GBX2_23144817_ChIP-Seq_PC3_Human2.04678750
19LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.04585842
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03901589
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.03001016
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01212367
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96735360
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.95987007
25GATA2_19941826_ChIP-Seq_K562_Human1.95303686
26HTT_18923047_ChIP-ChIP_STHdh_Human1.92181006
27DROSHA_22980978_ChIP-Seq_HELA_Human1.91783558
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90651453
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88880179
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.83236902
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81546779
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81539491
33AR_21572438_ChIP-Seq_LNCaP_Human1.79862094
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79375019
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75284789
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.70027719
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68901330
38GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68054657
39GATA1_19941827_ChIP-Seq_MEL_Mouse1.67424911
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.66467381
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65447693
42ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.61257349
43GATA4_21415370_ChIP-Seq_HL-1_Mouse1.60451552
44SPI1_23127762_ChIP-Seq_K562_Human1.58947415
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.57910603
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57603043
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56126875
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.55739644
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.55528230
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52873967
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.51662560
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50692232
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.49444986
54EZH2_22144423_ChIP-Seq_EOC_Human1.48997388
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43804365
56MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.41834506
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.38189169
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37963711
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37854856
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36908488
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36873943
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34011497
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34011497
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.33958263
65KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.32958019
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.32456761
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30026850
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29252222
69TFEB_21752829_ChIP-Seq_HELA_Human1.25866419
70IGF1R_20145208_ChIP-Seq_DFB_Human1.25784424
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25120689
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.25004571
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24809539
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.24754623
75TET1_21490601_ChIP-Seq_MESCs_Mouse1.24432237
76SOX2_20726797_ChIP-Seq_SW620_Human1.23586398
77REST_21632747_ChIP-Seq_MESCs_Mouse1.23204494
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22565136
79TBX5_21415370_ChIP-Seq_HL-1_Mouse1.22552537
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21659714
81RXR_22108803_ChIP-Seq_LS180_Human1.21538801
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.21478886
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19291233
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18358560
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17167932
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16688629
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15568332
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15005180
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14632890
90AHR_22903824_ChIP-Seq_MCF-7_Human1.11823234
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11727241
92CJUN_26792858_Chip-Seq_BT549_Human1.11191811
93LXR_22158963_ChIP-Seq_LIVER_Mouse1.10403685
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10271736
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09387922
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.06748443
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.06585960
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06517715
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05469890
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04937524
101SMAD4_21799915_ChIP-Seq_A2780_Human1.04001531
102KDM2B_26808549_Chip-Seq_K562_Human1.03299478
103TP53_18474530_ChIP-ChIP_U2OS_Human1.02906457
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02596039
105TP53_16413492_ChIP-PET_HCT116_Human1.02417267
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02326637
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02087826
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01349351
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01043661
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98044986
111EP300_21415370_ChIP-Seq_HL-1_Mouse0.97468971
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97405649
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96226167
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95740837
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95151498
116CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95074737
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93606707
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93183254
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92633002
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.92621366
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92607553
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.92536675
123GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92477886
124AR_25329375_ChIP-Seq_VCAP_Human0.92292673
125CDX2_20551321_ChIP-Seq_CACO-2_Human0.91796047
126SOX2_21211035_ChIP-Seq_LN229_Gbm0.90864608
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90470135
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89927897
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88907837
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88824096
131* BRD4_25478319_ChIP-Seq_HGPS_Human0.88257794
132SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86667239
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.86437270
134HNF4A_19822575_ChIP-Seq_HepG2_Human0.84553544
135TP53_20018659_ChIP-ChIP_R1E_Mouse0.84194186
136SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83615685
137BCAT_22108803_ChIP-Seq_LS180_Human0.82231363
138CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82123473
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81995548
140KLF5_25053715_ChIP-Seq_YYC3_Human0.81984206
141AR_19668381_ChIP-Seq_PC3_Human0.81816953
142EGR1_19032775_ChIP-ChIP_M12_Human0.81814057
143LXR_22292898_ChIP-Seq_THP-1_Human0.81673434
144E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.81073772
145NCOR1_26117541_ChIP-Seq_K562_Human0.80873770
146MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.80546858
147CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80429467
148GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80297377
149POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79825768
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79620644
151JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79457955
152TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78810296
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.78743603
154SMAD3_21741376_ChIP-Seq_EPCs_Human0.78300728
155CLOCK_20551151_ChIP-Seq_293T_Human0.78277592
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77916010
157STAT1_20625510_ChIP-Seq_HELA_Human0.77506668
158P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75305808
159TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.74033730
160CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.73977143
161ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73796834
162Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73662014
163TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.72698853
164TP53_23651856_ChIP-Seq_MEFs_Mouse0.72649866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.04606479
2MP0005464_abnormal_platelet_physiology3.71095679
3MP0004858_abnormal_nervous_system3.14178966
4MP0002132_abnormal_respiratory_system3.11291863
5MP0004270_analgesia2.82285144
6MP0002736_abnormal_nociception_after2.81883046
7MP0001968_abnormal_touch/_nociception2.74478691
8MP0003329_amyloid_beta_deposits2.57047282
9MP0009780_abnormal_chondrocyte_physiolo2.49632288
10MP0003183_abnormal_peptide_metabolism2.47731430
11MP0005058_abnormal_lysosome_morphology2.44793162
12MP0003635_abnormal_synaptic_transmissio2.39367723
13MP0002734_abnormal_mechanical_nocicepti2.34276182
14MP0002822_catalepsy2.33161733
15MP0004147_increased_porphyrin_level2.27927130
16MP0000569_abnormal_digit_pigmentation2.26636590
17MP0003880_abnormal_central_pattern2.16501558
18MP0008004_abnormal_stomach_pH2.05789742
19MP0002063_abnormal_learning/memory/cond2.00832701
20MP0002064_seizures1.99658671
21MP0009745_abnormal_behavioral_response1.97946024
22MP0002735_abnormal_chemical_nociception1.91142506
23MP0005623_abnormal_meninges_morphology1.86984889
24MP0002733_abnormal_thermal_nociception1.84245958
25MP0005365_abnormal_bile_salt1.83479364
26MP0005083_abnormal_biliary_tract1.83443861
27MP0000751_myopathy1.82389512
28MP0008438_abnormal_cutaneous_collagen1.79201783
29MP0001661_extended_life_span1.78995296
30MP0001970_abnormal_pain_threshold1.76847065
31MP0005275_abnormal_skin_tensile1.75954623
32MP0009046_muscle_twitch1.75755300
33MP0000749_muscle_degeneration1.74966534
34MP0003186_abnormal_redox_activity1.71185120
35MP0000604_amyloidosis1.70484202
36MP0001958_emphysema1.69871829
37MP0002090_abnormal_vision1.65049255
38MP0002909_abnormal_adrenal_gland1.64086291
39MP0003879_abnormal_hair_cell1.63874672
40MP0006036_abnormal_mitochondrial_physio1.60829714
41MP0005503_abnormal_tendon_morphology1.59756872
42MP0001984_abnormal_olfaction1.57773167
43MP0000343_altered_response_to1.57076800
44MP0004036_abnormal_muscle_relaxation1.55999020
45MP0002272_abnormal_nervous_system1.55216415
46MP0005451_abnormal_body_composition1.54838024
47MP0000013_abnormal_adipose_tissue1.53005524
48MP0008875_abnormal_xenobiotic_pharmacok1.52950471
49MP0003075_altered_response_to1.51889036
50MP0002295_abnormal_pulmonary_circulatio1.50978296
51MP0001545_abnormal_hematopoietic_system1.49423586
52MP0005397_hematopoietic_system_phenotyp1.49423586
53MP0004130_abnormal_muscle_cell1.46183188
54MP0002572_abnormal_emotion/affect_behav1.45034588
55MP0002139_abnormal_hepatobiliary_system1.44911783
56MP0008569_lethality_at_weaning1.39174672
57MP0002089_abnormal_postnatal_growth/wei1.38385379
58MP0001542_abnormal_bone_strength1.35169752
59MP0001501_abnormal_sleep_pattern1.30142105
60MP0001440_abnormal_grooming_behavior1.29460114
61MP0003633_abnormal_nervous_system1.29455678
62MP0005332_abnormal_amino_acid1.28554239
63MP0005584_abnormal_enzyme/coenzyme_acti1.26331805
64MP0001502_abnormal_circadian_rhythm1.24477668
65MP0003091_abnormal_cell_migration1.23697680
66MP0001299_abnormal_eye_distance/1.22204189
67MP0001346_abnormal_lacrimal_gland1.21552322
68MP0005636_abnormal_mineral_homeostasis1.19712479
69MP0003045_fibrosis1.19312091
70MP0005551_abnormal_eye_electrophysiolog1.18802060
71MP0004145_abnormal_muscle_electrophysio1.18688669
72MP0004084_abnormal_cardiac_muscle1.18078142
73MP0001486_abnormal_startle_reflex1.17348568
74MP0003656_abnormal_erythrocyte_physiolo1.16283246
75MP0002269_muscular_atrophy1.16015104
76MP0010329_abnormal_lipoprotein_level1.13326545
77MP0010234_abnormal_vibrissa_follicle1.12340029
78MP0003122_maternal_imprinting1.10933404
79MP0002067_abnormal_sensory_capabilities1.10820133
80MP0009384_cardiac_valve_regurgitation1.09997616
81MP0004811_abnormal_neuron_physiology1.09942206
82MP0005646_abnormal_pituitary_gland1.08550792
83MP0000358_abnormal_cell_content/1.08509819
84MP0004233_abnormal_muscle_weight1.07297336
85MP0008775_abnormal_heart_ventricle1.05644429
86MP0004134_abnormal_chest_morphology1.04702388
87MP0010386_abnormal_urinary_bladder1.03219711
88MP0002971_abnormal_brown_adipose1.01962682
89MP0005084_abnormal_gallbladder_morpholo1.01830230
90MP0003172_abnormal_lysosome_physiology1.01189085
91MP0003566_abnormal_cell_adhesion1.00388514
92MP0009840_abnormal_foam_cell0.98726807
93MP0002108_abnormal_muscle_morphology0.97696897
94MP0002184_abnormal_innervation0.97465698
95MP0002653_abnormal_ependyma_morphology0.97237405
96MP0003632_abnormal_nervous_system0.96870620
97MP0006035_abnormal_mitochondrial_morpho0.95912002
98MP0003631_nervous_system_phenotype0.95909064
99MP0000955_abnormal_spinal_cord0.95499107
100MP0002332_abnormal_exercise_endurance0.94859225
101MP0003634_abnormal_glial_cell0.94767420
102MP0003828_pulmonary_edema0.94743190
103MP0000759_abnormal_skeletal_muscle0.94608278
104MP0001533_abnormal_skeleton_physiology0.94047321
105MP0002102_abnormal_ear_morphology0.94000921
106MP0000920_abnormal_myelination0.93194775
107MP0002972_abnormal_cardiac_muscle0.92923557
108MP0001177_atelectasis0.92134549
109MP0002118_abnormal_lipid_homeostasis0.91855446
110MP0008260_abnormal_autophagy0.91600296
111MP0003690_abnormal_glial_cell0.91393419
112MP0002837_dystrophic_cardiac_calcinosis0.90947086
113MP0004885_abnormal_endolymph0.90497642
114MP0001664_abnormal_digestion0.90122575
115MP0004883_abnormal_blood_vessel0.89838979
116MP0003646_muscle_fatigue0.89692371
117MP0006054_spinal_hemorrhage0.89196874
118MP0000015_abnormal_ear_pigmentation0.88895304
119MP0000747_muscle_weakness0.88185156
120MP0000681_abnormal_thyroid_gland0.86601522
121MP0002796_impaired_skin_barrier0.84364905
122MP0005167_abnormal_blood-brain_barrier0.83577692
123MP0002882_abnormal_neuron_morphology0.82691594
124MP0002066_abnormal_motor_capabilities/c0.82634151
125MP0003950_abnormal_plasma_membrane0.82439867
126MP0010771_integument_phenotype0.82306993
127MP0001666_abnormal_nutrient_absorption0.81892737
128MP0005164_abnormal_response_to0.81335232
129MP0003283_abnormal_digestive_organ0.80745768
130MP0006276_abnormal_autonomic_nervous0.78764163
131MP0001529_abnormal_vocalization0.77954967
132MP0003959_abnormal_lean_body0.77318891
133MP0008872_abnormal_physiological_respon0.76748369
134MP0003191_abnormal_cellular_cholesterol0.75696403
135MP0004947_skin_inflammation0.75542604
136MP0002229_neurodegeneration0.75405673
137MP0005595_abnormal_vascular_smooth0.75013771
138MP0002557_abnormal_social/conspecific_i0.74935977
139MP0003300_gastrointestinal_ulcer0.74493931
140MP0003638_abnormal_response/metabolism_0.74297869
141MP0008874_decreased_physiological_sensi0.73287064
142MP0001188_hyperpigmentation0.72706523
143MP0002078_abnormal_glucose_homeostasis0.71295051
144MP0002998_abnormal_bone_remodeling0.70807536
145MP0005410_abnormal_fertilization0.70700305
146MP0000230_abnormal_systemic_arterial0.69693240
147MP0005620_abnormal_muscle_contractility0.67306228
148MP0005166_decreased_susceptibility_to0.66051958
149MP0002876_abnormal_thyroid_physiology0.65933641

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)5.68346821
2Prolonged bleeding time (HP:0003010)4.84892990
3Type 1 muscle fiber predominance (HP:0003803)4.03001257
4Abnormal platelet function (HP:0011869)4.00861822
5Impaired platelet aggregation (HP:0003540)4.00861822
6Abnormality of the heme biosynthetic pathway (HP:0010472)3.76119685
7Acanthocytosis (HP:0001927)3.61479100
8Ileus (HP:0002595)3.54762325
9Purpura (HP:0000979)3.54560660
10Menorrhagia (HP:0000132)3.53722513
11Increased mean platelet volume (HP:0011877)3.52268293
12Muscle fiber inclusion bodies (HP:0100299)3.51605733
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.46345014
14Nemaline bodies (HP:0003798)3.44487104
15Myokymia (HP:0002411)3.43293677
16Abnormal platelet volume (HP:0011876)3.28177510
17Poikilocytosis (HP:0004447)3.27840564
18Fetal akinesia sequence (HP:0001989)3.26851764
19Reticulocytosis (HP:0001923)3.20804876
20Ankle clonus (HP:0011448)3.09391147
21Polycythemia (HP:0001901)3.07169986
22Distal arthrogryposis (HP:0005684)3.03181568
23Hyperinsulinemic hypoglycemia (HP:0000825)3.00121530
24Focal motor seizures (HP:0011153)2.90457162
25Hyperthyroidism (HP:0000836)2.89881479
26Gingival bleeding (HP:0000225)2.85762080
27Epistaxis (HP:0000421)2.79244865
28Short middle phalanx of the 5th finger (HP:0004220)2.74560523
29Neonatal short-limb short stature (HP:0008921)2.71396108
30Hyperlipoproteinemia (HP:0010980)2.68989079
31Cholecystitis (HP:0001082)2.61107546
32Abnormal gallbladder physiology (HP:0012438)2.61107546
33Increased variability in muscle fiber diameter (HP:0003557)2.60150350
34Supranuclear gaze palsy (HP:0000605)2.59842792
35Akinesia (HP:0002304)2.58910843
36Epileptic encephalopathy (HP:0200134)2.58890876
37Abnormality of glycolipid metabolism (HP:0010969)2.58888382
38Abnormality of liposaccharide metabolism (HP:0010968)2.58888382
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.58888382
40Abnormality of skeletal muscle fiber size (HP:0012084)2.58877337
41Cupped ribs (HP:0000887)2.56863898
42Exercise-induced myalgia (HP:0003738)2.56407452
43Focal seizures (HP:0007359)2.49371835
44Myopathic facies (HP:0002058)2.48292459
45Atonic seizures (HP:0010819)2.48259887
46Epiphyseal dysplasia (HP:0002656)2.46442786
47Mildly elevated creatine phosphokinase (HP:0008180)2.44873637
48Premature rupture of membranes (HP:0001788)2.43237074
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.40667043
50Protrusio acetabuli (HP:0003179)2.35758288
51Complete atrioventricular canal defect (HP:0001674)2.34690132
52Ulnar deviation of the wrist (HP:0003049)2.31663854
53Torticollis (HP:0000473)2.31615633
54Xanthomatosis (HP:0000991)2.29661881
55Absent phalangeal crease (HP:0006109)2.29405075
56Hydroxyprolinuria (HP:0003080)2.25774171
57Abnormality of proline metabolism (HP:0010907)2.25774171
58Scapular winging (HP:0003691)2.24101617
59Irregular epiphyses (HP:0010582)2.23670326
60Microglossia (HP:0000171)2.22331084
61Broad metatarsal (HP:0001783)2.22040091
62Vertebral compression fractures (HP:0002953)2.21197909
63Abnormality of glycolysis (HP:0004366)2.19878458
64Delusions (HP:0000746)2.18716423
65Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.18677505
66Mitral stenosis (HP:0001718)2.18456014
67Central scotoma (HP:0000603)2.17493847
68Increased serum pyruvate (HP:0003542)2.16793548
69Hypoventilation (HP:0002791)2.16543320
70Mutism (HP:0002300)2.16263940
71Neurofibrillary tangles (HP:0002185)2.15416267
72Hypoplastic iliac wings (HP:0002866)2.15343904
73Pheochromocytoma (HP:0002666)2.15004249
74Round ear (HP:0100830)2.13446696
75Congenital stationary night blindness (HP:0007642)2.12963065
76Aplasia involving bones of the extremities (HP:0009825)2.11208554
77Aplasia involving bones of the upper limbs (HP:0009823)2.11208554
78Aplasia of the phalanges of the hand (HP:0009802)2.11208554
79Hypokinesia (HP:0002375)2.10990935
80Lumbar hyperlordosis (HP:0002938)2.10566929
81Lower limb amyotrophy (HP:0007210)2.09885534
82Vacuolated lymphocytes (HP:0001922)2.09873718
83Abnormality of dental color (HP:0011073)2.08841978
84Calcaneovalgus deformity (HP:0001848)2.08601616
85Upper limb muscle weakness (HP:0003484)2.08320285
86Cholelithiasis (HP:0001081)2.06769931
87Visual hallucinations (HP:0002367)2.05546249
88Abnormality of magnesium homeostasis (HP:0004921)2.03914444
89Hyporeflexia of lower limbs (HP:0002600)2.00951358
90Febrile seizures (HP:0002373)1.99856245
91Gowers sign (HP:0003391)1.97836249
92Ovoid vertebral bodies (HP:0003300)1.97701432
93Atrioventricular canal defect (HP:0006695)1.97008030
94Acute necrotizing encephalopathy (HP:0006965)1.96427630
95Abnormal gallbladder morphology (HP:0012437)1.96138792
96Dysostosis multiplex (HP:0000943)1.95363105
97Bruising susceptibility (HP:0000978)1.95200058
98Hip contracture (HP:0003273)1.94996632
99Abnormality of the common coagulation pathway (HP:0010990)1.94829428
100Hypomagnesemia (HP:0002917)1.94643824
101Action tremor (HP:0002345)1.94509590
102Slender build (HP:0001533)1.93494571
103Vascular tortuosity (HP:0004948)1.93442576
104Abnormal mitochondria in muscle tissue (HP:0008316)1.93441465
105Distal lower limb amyotrophy (HP:0008944)1.93144340
106Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92384818
107Degeneration of the lateral corticospinal tracts (HP:0002314)1.92384818
108Craniofacial dystonia (HP:0012179)1.90301590
109Osteoarthritis (HP:0002758)1.88978917
110Deformed tarsal bones (HP:0008119)1.88738164
111Aortic aneurysm (HP:0004942)1.88708642
112Hepatic necrosis (HP:0002605)1.88617164
113Focal dystonia (HP:0004373)1.88048399
114Neuroendocrine neoplasm (HP:0100634)1.87328957
115Absence seizures (HP:0002121)1.87215029
116Frequent falls (HP:0002359)1.86488512
117Upper limb amyotrophy (HP:0009129)1.85830441
118Distal upper limb amyotrophy (HP:0007149)1.85830441
119Difficulty running (HP:0009046)1.85602468
120Dilatation of the ascending aorta (HP:0005111)1.85522639
121Brushfield spots (HP:0001088)1.85356242
122Lower limb muscle weakness (HP:0007340)1.85247174
123Muscle stiffness (HP:0003552)1.84400493
124Weak cry (HP:0001612)1.83749051
125Cervical subluxation (HP:0003308)1.83149234
126Flat acetabular roof (HP:0003180)1.83124857
127Pterygium (HP:0001059)1.82774971
128Abnormality of macular pigmentation (HP:0008002)1.82564432
129Skin nodule (HP:0200036)1.81711749
130Acute encephalopathy (HP:0006846)1.80666668
131Mild short stature (HP:0003502)1.79486707
132Distal lower limb muscle weakness (HP:0009053)1.78988533
133Abnormal finger flexion creases (HP:0006143)1.78934892
134Hypercortisolism (HP:0001578)1.78655401
135Vitreoretinal degeneration (HP:0000655)1.78034837
136Ventricular fibrillation (HP:0001663)1.77174237
137Abnormality of the corticospinal tract (HP:0002492)1.77064226
138Peritonitis (HP:0002586)1.76253989
139Arterial tortuosity (HP:0005116)1.75539728
140Ankle contracture (HP:0006466)1.75030253
141Symphalangism affecting the phalanges of the hand (HP:0009773)1.74333245
142Popliteal pterygium (HP:0009756)1.74113715
143Abnormal eating behavior (HP:0100738)1.74039607
144Megalencephaly (HP:0001355)1.73749423
145Flat capital femoral epiphysis (HP:0003370)1.72916831
146Hammertoe (HP:0001765)1.72335602
147Abnormality of the acetabulum (HP:0003170)1.72167774
148Hemiparesis (HP:0001269)1.71622522
149Urinary urgency (HP:0000012)1.70630115
150Abnormality of polysaccharide metabolism (HP:0011012)1.70511362
151Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70511362
152Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70511362
153Increased CSF lactate (HP:0002490)1.70434987
154Shallow orbits (HP:0000586)1.70273699
155Spinal canal stenosis (HP:0003416)1.69376854
156Ketoacidosis (HP:0001993)1.68901154
157Dialeptic seizures (HP:0011146)1.68617703
158Progressive macrocephaly (HP:0004481)1.68563040
159Abnormality of the calcaneus (HP:0008364)1.68492930
160Diminished movement (HP:0002374)1.67518421
161Depression (HP:0000716)1.67400155
162Hyperalaninemia (HP:0003348)1.66828934
163Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66828934
164Abnormality of alanine metabolism (HP:0010916)1.66828934
165Cerebral inclusion bodies (HP:0100314)1.66355624
166Clonus (HP:0002169)1.65992151
167EMG: myopathic abnormalities (HP:0003458)1.65832396
168Limited hip movement (HP:0008800)1.65804986
169Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.65197939
170Delayed gross motor development (HP:0002194)1.64651627
171Progressive microcephaly (HP:0000253)1.64451641
172Hepatocellular necrosis (HP:0001404)1.64230545
173Increased cerebral lipofuscin (HP:0011813)1.63747514
174Spinal rigidity (HP:0003306)1.63266102
175Right ventricular cardiomyopathy (HP:0011663)1.62687403
176Abnormality of the calf musculature (HP:0001430)1.61364072
177Generalized tonic-clonic seizures (HP:0002069)1.60668659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.41775880
2PDK22.31464810
3MYLK2.30974215
4DDR22.30357167
5NTRK32.29044108
6MAP3K122.25626883
7EPHA42.16126010
8LIMK12.06493454
9NTRK12.02584797
10MAP3K92.01460334
11DAPK21.98374048
12MAPK131.93177060
13PIM21.89832876
14TRIB31.80350860
15LMTK21.80185152
16MARK11.79894280
17MINK11.78798855
18PNCK1.75995888
19KSR21.74133852
20STK101.71252327
21CAMKK21.66826607
22ARAF1.64975817
23EPHB11.63536180
24PAK61.63319071
25MAP4K21.61319760
26NTRK21.59012851
27WNK41.51893639
28CASK1.51771559
29MAP3K21.51203438
30CAMKK11.51200776
31MST1R1.42159379
32TAOK11.39633441
33SGK2231.38363981
34SGK4941.38363981
35SIK31.33002799
36MOS1.32812200
37FER1.32187200
38TAOK31.31838129
39RIPK11.30540771
40RIPK41.28436923
41MAP3K41.27671991
42CDK51.27438746
43MAP2K11.26543752
44TESK11.23356286
45SIK21.16398105
46ERN11.15955069
47CAMK2G1.13386510
48PRKD31.11710086
49CAMK11.07080381
50PIK3CG1.06748203
51KSR11.06545155
52RAF11.03558446
53TYRO31.02993292
54BRSK11.00171732
55EPHB20.99162004
56TRPM70.99110766
57PLK20.99022398
58PTK2B0.98341727
59CDK80.97769515
60ROCK20.97755887
61ERBB30.97436150
62MAP2K30.97209857
63RET0.96665470
64MAP2K70.94848634
65IRAK30.93361195
66FES0.92901523
67MAP3K10.92632472
68PKN10.91652331
69GRK50.91507213
70PRKG20.91389206
71SGK20.91369009
72ROCK10.89472848
73TTN0.88385179
74SGK30.87317355
75PHKG20.87108138
76PHKG10.87108138
77ABL20.84665421
78AKT30.83308023
79MAP3K130.83212206
80PTK20.82907740
81EPHA30.81954542
82PRPF4B0.81710941
83CDK180.81338991
84MAPKAPK50.80755483
85PRKCH0.78921700
86CDK140.77965504
87FGFR20.77857338
88OBSCN0.77265511
89ILK0.76901087
90OXSR10.76634482
91PRKD10.76522118
92DAPK10.76379691
93TRIM280.75265339
94FRK0.75053815
95PINK10.74669375
96CAMK2D0.73612230
97CAMK2B0.72965087
98CDK150.72723957
99PDGFRA0.71839899
100BMPR20.70520205
101PAK10.70055013
102PDPK10.69937883
103MAP2K60.69471924
104PDK10.69188654
105BMX0.68822816
106PRKCE0.68365892
107FGFR40.67987476
108CDK190.67701348
109MAP2K40.67631828
110MAP3K80.67064902
111TNK20.66228789
112PRKCZ0.65105456
113ADRBK10.59933620
114PRKCG0.59330764
115DAPK30.59145202
116BRAF0.58838405
117MET0.57990580
118MAP3K30.57163485
119LRRK20.56095552
120CDK11A0.55595506
121MST40.55293196
122NEK20.54978877
123MARK20.54156860
124FGR0.54108839
125PAK30.53580682
126JAK10.52282684
127PTK60.51628912
128PAK40.50451506
129BCR0.49819839
130RPS6KA20.49607390
131CAMK2A0.48662972
132CCNB10.48168316
133PRKACG0.47721721
134WNK10.46476695
135BCKDK0.46291737
136DMPK0.45892626
137GRK70.43819532
138DYRK20.41970210

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.88213117
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.54218198
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.51331102
4Olfactory transduction_Homo sapiens_hsa047402.01996807
5Glycosaminoglycan degradation_Homo sapiens_hsa005311.81901384
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77796018
7Other glycan degradation_Homo sapiens_hsa005111.69993745
8Circadian entrainment_Homo sapiens_hsa047131.69257864
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64217088
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63846756
11GABAergic synapse_Homo sapiens_hsa047271.63225903
12Collecting duct acid secretion_Homo sapiens_hsa049661.55347527
13Salivary secretion_Homo sapiens_hsa049701.51340545
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.50722670
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49306324
16Butanoate metabolism_Homo sapiens_hsa006501.46065501
17Vibrio cholerae infection_Homo sapiens_hsa051101.45879873
18Nicotine addiction_Homo sapiens_hsa050331.45752116
19Morphine addiction_Homo sapiens_hsa050321.39969825
20Cholinergic synapse_Homo sapiens_hsa047251.39755391
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38591885
22Renin secretion_Homo sapiens_hsa049241.35168969
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33247209
24Insulin secretion_Homo sapiens_hsa049111.30667760
25Dopaminergic synapse_Homo sapiens_hsa047281.30115032
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29248043
27Arginine and proline metabolism_Homo sapiens_hsa003301.27765726
28Carbon metabolism_Homo sapiens_hsa012001.25147137
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25015707
30Glutamatergic synapse_Homo sapiens_hsa047241.21448278
31Gastric acid secretion_Homo sapiens_hsa049711.21119281
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19716217
33Oxytocin signaling pathway_Homo sapiens_hsa049211.19346560
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16850701
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.15103697
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13460053
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12526583
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12470114
39Gap junction_Homo sapiens_hsa045401.11374649
40GnRH signaling pathway_Homo sapiens_hsa049121.10891326
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07662261
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06441243
43Cocaine addiction_Homo sapiens_hsa050301.06375894
44Arginine biosynthesis_Homo sapiens_hsa002201.06029048
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05994083
46Amphetamine addiction_Homo sapiens_hsa050311.05900655
47Phagosome_Homo sapiens_hsa041451.05881943
48Pentose phosphate pathway_Homo sapiens_hsa000301.05026369
49Serotonergic synapse_Homo sapiens_hsa047261.04821979
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04367490
51Fatty acid metabolism_Homo sapiens_hsa012121.04354994
52Lysosome_Homo sapiens_hsa041421.00142956
53Sulfur metabolism_Homo sapiens_hsa009200.99954298
54Regulation of autophagy_Homo sapiens_hsa041400.99068777
55Axon guidance_Homo sapiens_hsa043600.98129384
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96994137
57Long-term potentiation_Homo sapiens_hsa047200.96692406
58Dilated cardiomyopathy_Homo sapiens_hsa054140.96571924
59Caffeine metabolism_Homo sapiens_hsa002320.95964593
60Long-term depression_Homo sapiens_hsa047300.95648685
61Phototransduction_Homo sapiens_hsa047440.93529157
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93065253
63Mineral absorption_Homo sapiens_hsa049780.91597568
64Peroxisome_Homo sapiens_hsa041460.91317389
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91064192
66Glioma_Homo sapiens_hsa052140.90450944
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90263247
68Renin-angiotensin system_Homo sapiens_hsa046140.89619905
69Pyruvate metabolism_Homo sapiens_hsa006200.86527245
70beta-Alanine metabolism_Homo sapiens_hsa004100.86478719
71ECM-receptor interaction_Homo sapiens_hsa045120.86424081
72Complement and coagulation cascades_Homo sapiens_hsa046100.85518984
73Sphingolipid metabolism_Homo sapiens_hsa006000.85175336
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84563245
75Glutathione metabolism_Homo sapiens_hsa004800.84115085
76Calcium signaling pathway_Homo sapiens_hsa040200.81379314
77Protein digestion and absorption_Homo sapiens_hsa049740.81362415
78ErbB signaling pathway_Homo sapiens_hsa040120.80362339
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80226467
80Biosynthesis of amino acids_Homo sapiens_hsa012300.78980561
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78224877
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77218425
83Endocytosis_Homo sapiens_hsa041440.73507871
84Bile secretion_Homo sapiens_hsa049760.72933873
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.72872840
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.72796254
87cAMP signaling pathway_Homo sapiens_hsa040240.72278737
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71637710
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70655345
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.70164289
91Focal adhesion_Homo sapiens_hsa045100.70082814
92Salmonella infection_Homo sapiens_hsa051320.69702730
93Fatty acid degradation_Homo sapiens_hsa000710.69646493
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68185787
95Taste transduction_Homo sapiens_hsa047420.67703330
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67633711
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67497797
98Cardiac muscle contraction_Homo sapiens_hsa042600.66267338
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65559515
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65416265
101Bladder cancer_Homo sapiens_hsa052190.65083428
102Nitrogen metabolism_Homo sapiens_hsa009100.64526333
103Thyroid hormone synthesis_Homo sapiens_hsa049180.63877383
104VEGF signaling pathway_Homo sapiens_hsa043700.63683257
105Fatty acid elongation_Homo sapiens_hsa000620.62978891
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62333262
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61578513
108Oxidative phosphorylation_Homo sapiens_hsa001900.61402578
109Propanoate metabolism_Homo sapiens_hsa006400.59235768
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58975853
111Rheumatoid arthritis_Homo sapiens_hsa053230.58748381
112PPAR signaling pathway_Homo sapiens_hsa033200.57777598
113Amoebiasis_Homo sapiens_hsa051460.55500767
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55482467
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54989169
116Estrogen signaling pathway_Homo sapiens_hsa049150.54189308
117Glucagon signaling pathway_Homo sapiens_hsa049220.54075793
118Glycerolipid metabolism_Homo sapiens_hsa005610.53749145
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53010741
120Type II diabetes mellitus_Homo sapiens_hsa049300.52892797
121Proteoglycans in cancer_Homo sapiens_hsa052050.52734083
122Galactose metabolism_Homo sapiens_hsa000520.50937757
123Circadian rhythm_Homo sapiens_hsa047100.50677382
124MAPK signaling pathway_Homo sapiens_hsa040100.50014362
125Tyrosine metabolism_Homo sapiens_hsa003500.49592121
126Platelet activation_Homo sapiens_hsa046110.49304351
127Starch and sucrose metabolism_Homo sapiens_hsa005000.48928096
128Fatty acid biosynthesis_Homo sapiens_hsa000610.46729066
129Insulin signaling pathway_Homo sapiens_hsa049100.46629674
130Pancreatic secretion_Homo sapiens_hsa049720.46557075
131Fructose and mannose metabolism_Homo sapiens_hsa000510.46545657
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46538277
133AMPK signaling pathway_Homo sapiens_hsa041520.46051774
134Tuberculosis_Homo sapiens_hsa051520.45234558
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44833578
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44520606
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.43367171
138Rap1 signaling pathway_Homo sapiens_hsa040150.42699282
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42293094
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41760348
141Tight junction_Homo sapiens_hsa045300.41102706
142Chemical carcinogenesis_Homo sapiens_hsa052040.39135031

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