MID1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Alternative promoter use, alternative splicing and alternative polyadenylation result in multiple transcript variants that have different tissue specificities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.27149784
2nuclear pore organization (GO:0006999)5.81556782
3pore complex assembly (GO:0046931)5.04886037
4paraxial mesoderm development (GO:0048339)4.83931703
5pre-miRNA processing (GO:0031054)4.32008623
6regulation of posttranscriptional gene silencing (GO:0060147)4.24456498
7regulation of gene silencing by miRNA (GO:0060964)4.24456498
8regulation of gene silencing by RNA (GO:0060966)4.24456498
9mitotic sister chromatid cohesion (GO:0007064)3.92469118
10negative regulation of translation, ncRNA-mediated (GO:0040033)3.85914504
11regulation of translation, ncRNA-mediated (GO:0045974)3.85914504
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.85914504
13negative regulation of histone methylation (GO:0031061)3.74455375
14positive regulation of SMAD protein import into nucleus (GO:0060391)3.59884000
15limb bud formation (GO:0060174)3.59674362
16histone H3-K36 demethylation (GO:0070544)3.46909448
17regulation of histone H3-K9 methylation (GO:0051570)3.40265886
18mitotic metaphase plate congression (GO:0007080)3.34085217
19chromatin remodeling at centromere (GO:0031055)3.31394378
20regulation of DNA damage checkpoint (GO:2000001)3.26444694
21neuron projection extension involved in neuron projection guidance (GO:1902284)3.22707731
22axon extension involved in axon guidance (GO:0048846)3.22707731
23positive regulation of cell cycle checkpoint (GO:1901978)3.21983423
24metaphase plate congression (GO:0051310)3.21325248
25CENP-A containing nucleosome assembly (GO:0034080)3.16960590
26presynaptic membrane assembly (GO:0097105)3.16954050
27RNA stabilization (GO:0043489)3.11075125
28mRNA stabilization (GO:0048255)3.11075125
29mitotic nuclear envelope disassembly (GO:0007077)3.10201752
30regulation of SMAD protein import into nucleus (GO:0060390)3.08473873
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07549926
32regulation of helicase activity (GO:0051095)3.05050775
33regulation of gene silencing (GO:0060968)2.99826092
34protein localization to chromosome, centromeric region (GO:0071459)2.98399601
35planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96940321
36negative regulation of osteoblast proliferation (GO:0033689)2.93002100
37glucocorticoid receptor signaling pathway (GO:0042921)2.90813135
38regulation of translational fidelity (GO:0006450)2.90339132
39positive regulation of gene expression, epigenetic (GO:0045815)2.89433306
40presynaptic membrane organization (GO:0097090)2.89168428
41cytoplasmic mRNA processing body assembly (GO:0033962)2.88706720
42membrane disassembly (GO:0030397)2.86958565
43nuclear envelope disassembly (GO:0051081)2.86958565
44regulation of mitotic spindle organization (GO:0060236)2.84796538
45regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84476801
46kinetochore organization (GO:0051383)2.83170547
47retinal ganglion cell axon guidance (GO:0031290)2.82660192
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.81749729
49DNA unwinding involved in DNA replication (GO:0006268)2.81444231
50microtubule depolymerization (GO:0007019)2.75843719
51wound healing, spreading of epidermal cells (GO:0035313)2.75428389
52ventricular cardiac muscle cell development (GO:0055015)2.75278355
53negative regulation of axon guidance (GO:1902668)2.74339402
54histone H3-K4 trimethylation (GO:0080182)2.73603719
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73291004
56post-anal tail morphogenesis (GO:0036342)2.72084807
57histone lysine demethylation (GO:0070076)2.71399084
58intraciliary transport (GO:0042073)2.68481405
59negative regulation of mRNA processing (GO:0050686)2.67693403
60epithelial cilium movement (GO:0003351)2.67536028
61forebrain neuron differentiation (GO:0021879)2.65755364
62DNA geometric change (GO:0032392)2.65104550
63negative regulation of RNA splicing (GO:0033119)2.64261753
64DNA duplex unwinding (GO:0032508)2.62694557
65kinetochore assembly (GO:0051382)2.62679658
66histone exchange (GO:0043486)2.62304314
67histone H3-K9 methylation (GO:0051567)2.62237298
68heterochromatin organization (GO:0070828)2.61975928
69artery development (GO:0060840)2.61693036
70regulation of hippo signaling (GO:0035330)2.61329874
713-UTR-mediated mRNA stabilization (GO:0070935)2.61118005
72positive regulation of RNA splicing (GO:0033120)2.61054606
73regulation of DNA endoreduplication (GO:0032875)2.60865855
74establishment of integrated proviral latency (GO:0075713)2.59832246
75regulation of stem cell maintenance (GO:2000036)2.58357376
76pyrimidine nucleobase catabolic process (GO:0006208)2.58305558
77regulation of spindle organization (GO:0090224)2.57875096
78positive regulation of gastrulation (GO:2000543)2.56443810
79axonal fasciculation (GO:0007413)2.55799369
80histone demethylation (GO:0016577)2.55402426
81establishment of planar polarity (GO:0001736)2.54224702
82establishment of tissue polarity (GO:0007164)2.54224702
83DNA replication-independent nucleosome organization (GO:0034724)2.53586939
84DNA replication-independent nucleosome assembly (GO:0006336)2.53586939
85regulation of chromatin silencing (GO:0031935)2.53374197
86anterior/posterior axis specification, embryo (GO:0008595)2.53240458
87notochord development (GO:0030903)2.52663366
88protein localization to kinetochore (GO:0034501)2.52130444
89histone H3-K9 modification (GO:0061647)2.51979190
90sister chromatid segregation (GO:0000819)2.50665906
91G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.50624502
92regulation of mRNA stability (GO:0043488)2.50473709
93spindle checkpoint (GO:0031577)2.50441448
94hippo signaling (GO:0035329)2.48048154
95somite development (GO:0061053)2.47983291
96meiotic chromosome segregation (GO:0045132)2.47214898
97regulation of telomere maintenance via telomerase (GO:0032210)2.47134161
98regulation of non-canonical Wnt signaling pathway (GO:2000050)2.46509114
99regulation of RNA export from nucleus (GO:0046831)2.45851261
100mitotic sister chromatid segregation (GO:0000070)2.45553763
101lateral sprouting from an epithelium (GO:0060601)2.45194572
102DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.43343528
103nonmotile primary cilium assembly (GO:0035058)2.43219113
104midbrain development (GO:0030901)2.42973934
105histone H2A monoubiquitination (GO:0035518)2.42492875
106mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.42469966
107apical protein localization (GO:0045176)2.41660841
108establishment of apical/basal cell polarity (GO:0035089)2.41461314
109NLS-bearing protein import into nucleus (GO:0006607)2.41425772
110DNA ligation (GO:0006266)2.39784130
111cilium movement (GO:0003341)2.39179516
112dosage compensation (GO:0007549)2.38382391
113regulation of centrosome cycle (GO:0046605)2.38209191
114establishment of chromosome localization (GO:0051303)2.37946210
115regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.37928479
116histone H3-K4 methylation (GO:0051568)2.37901331
117chromatin assembly (GO:0031497)2.37845125
118IMP biosynthetic process (GO:0006188)2.37742744
119negative regulation of mRNA metabolic process (GO:1903312)2.36414795
120otic vesicle formation (GO:0030916)2.36289765
121regulation of RNA stability (GO:0043487)2.36051112
122lung-associated mesenchyme development (GO:0060484)2.35528653
123cerebral cortex radially oriented cell migration (GO:0021799)2.35305015
124generation of neurons (GO:0048699)2.35019613
125nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.34992887
126cell surface receptor signaling pathway involved in heart development (GO:0061311)2.34230306
127neuron recognition (GO:0008038)2.33945700
128DNA strand renaturation (GO:0000733)2.33803646
129mRNA splice site selection (GO:0006376)2.33323266
130regulation of centrosome duplication (GO:0010824)2.32710788
131nodal signaling pathway (GO:0038092)2.32661716
132negative chemotaxis (GO:0050919)2.32501610
133corticosteroid receptor signaling pathway (GO:0031958)2.31752743
134positive regulation of neuroblast proliferation (GO:0002052)2.31441915
135peptidyl-lysine trimethylation (GO:0018023)2.31210358
136thalamus development (GO:0021794)2.31102194
137negative regulation of chromatin modification (GO:1903309)2.30848638
138regulation of mitotic spindle checkpoint (GO:1903504)2.30197952
139regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.30197952
140DNA replication-dependent nucleosome organization (GO:0034723)2.29015994
141DNA replication-dependent nucleosome assembly (GO:0006335)2.29015994
142regulation of integrin activation (GO:0033623)2.28758129
143response to pheromone (GO:0019236)2.28261793
144negative regulation of gene silencing (GO:0060969)2.27565231
145alternative mRNA splicing, via spliceosome (GO:0000380)2.27546799
146DNA damage response, detection of DNA damage (GO:0042769)2.26180113
147I-kappaB phosphorylation (GO:0007252)2.25066696
148mitotic spindle organization (GO:0007052)2.24915290
149DNA replication checkpoint (GO:0000076)2.23288456
150Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.22159418
151mitotic spindle checkpoint (GO:0071174)2.20788458
152convergent extension (GO:0060026)2.18512828
153axonemal dynein complex assembly (GO:0070286)2.16613287
154neuron fate determination (GO:0048664)2.15756611
155embryonic foregut morphogenesis (GO:0048617)2.15393623
156regulation of establishment of planar polarity (GO:0090175)2.14976676
157postsynaptic membrane organization (GO:0001941)2.12927228
158dorsal/ventral axis specification (GO:0009950)2.12459492
159regulation of axon guidance (GO:1902667)2.11280728
160smoothened signaling pathway (GO:0007224)2.11139484
161DNA double-strand break processing (GO:0000729)2.10492457
162ATP-dependent chromatin remodeling (GO:0043044)2.10361047
163resolution of meiotic recombination intermediates (GO:0000712)2.10329194
164sequestering of actin monomers (GO:0042989)2.09989666
165mitotic chromosome condensation (GO:0007076)2.09916171
166non-canonical Wnt signaling pathway (GO:0035567)2.09540643
167lens fiber cell development (GO:0070307)2.09117967
168hindbrain development (GO:0030902)2.09090340
169centriole replication (GO:0007099)2.08232745
170negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.07652372
171negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.07652372
172negative regulation of mitotic sister chromatid segregation (GO:0033048)2.07652372
173negative regulation of mitotic sister chromatid separation (GO:2000816)2.07652372
174negative regulation of sister chromatid segregation (GO:0033046)2.07652372
175protein localization to chromosome (GO:0034502)2.07554192
176outer ear morphogenesis (GO:0042473)2.06474957
177negative regulation of chromosome segregation (GO:0051985)2.06308341
178regulation of chromosome segregation (GO:0051983)2.05993237
179neuronal stem cell maintenance (GO:0097150)2.05970627
180tongue development (GO:0043586)2.05847034
181regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.05208521
182hindlimb morphogenesis (GO:0035137)2.04080509
183olfactory bulb development (GO:0021772)2.03923332
184attachment of spindle microtubules to kinetochore (GO:0008608)2.03498677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.82786240
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.90132865
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.40881512
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56511622
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.32546095
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.25964076
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.08810294
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.04804158
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.94378066
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.94331884
11EZH2_22144423_ChIP-Seq_EOC_Human2.91388495
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71316868
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65225918
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.52084566
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48295064
16MYC_22102868_ChIP-Seq_BL_Human2.47845843
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.44382355
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.44382355
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.44382355
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40236660
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.34538000
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.24156429
23FUS_26573619_Chip-Seq_HEK293_Human2.18056768
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.14650163
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13385287
26ZFP281_27345836_Chip-Seq_ESCs_Mouse2.09774148
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.09307932
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08364646
29TCF3_18692474_ChIP-Seq_MEFs_Mouse2.06441658
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.03437408
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97405373
32* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97334713
33TCF3_18692474_ChIP-Seq_MESCs_Mouse1.96336469
34* EWS_26573619_Chip-Seq_HEK293_Human1.95460546
35GBX2_23144817_ChIP-Seq_PC3_Human1.92483623
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.85423488
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84491733
38TAF15_26573619_Chip-Seq_HEK293_Human1.83211834
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.82730909
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78836393
41NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.75961446
42SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.73932475
43* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72902821
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72242587
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.68229379
46AR_21909140_ChIP-Seq_LNCAP_Human1.67310032
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67239058
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63391155
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62295436
50P300_19829295_ChIP-Seq_ESCs_Human1.61382107
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59631094
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.59567144
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.59546635
54VDR_22108803_ChIP-Seq_LS180_Human1.58098442
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56780616
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55332196
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.55125284
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54589495
59GABP_17652178_ChIP-ChIP_JURKAT_Human1.50936643
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.50737492
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48872986
62ELK1_19687146_ChIP-ChIP_HELA_Human1.47588190
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.47209019
64ZNF274_21170338_ChIP-Seq_K562_Hela1.46912823
65NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.46755567
66RNF2_27304074_Chip-Seq_NSC_Mouse1.45988117
67FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.45179021
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42143882
69TCF7_22412390_ChIP-Seq_EML_Mouse1.42000603
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.41918914
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.41296345
72IGF1R_20145208_ChIP-Seq_DFB_Human1.41184139
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40659720
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40251038
75PKCTHETA_26484144_Chip-Seq_BREAST_Human1.36450698
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35341838
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33870904
78* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32248006
79SOX9_26525672_Chip-Seq_HEART_Mouse1.29204356
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29038090
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28167295
82POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.28054743
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27649458
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27612874
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27160142
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26042762
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25264234
88* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23241363
89* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.23152833
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23076682
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22742651
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.22494412
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21859109
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21337915
95* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.20270431
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20077360
97MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19506866
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19489387
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17141453
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16669101
101CIITA_25753668_ChIP-Seq_RAJI_Human1.15792583
102* SMAD4_21799915_ChIP-Seq_A2780_Human1.15311640
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15120337
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.14691704
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14587450
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14325407
107SOX2_18692474_ChIP-Seq_MESCs_Mouse1.13926126
108CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13897036
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12877491
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12877491
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11192924
112KDM2B_26808549_Chip-Seq_DND41_Human1.10879002
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10030137
114* XRN2_22483619_ChIP-Seq_HELA_Human1.09772671
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09685078
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09618407
117POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09354405
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09216042
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08610053
120ISL1_27105846_Chip-Seq_CPCs_Mouse1.07153435
121GATA1_26923725_Chip-Seq_HPCs_Mouse1.05690469
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05662143
123* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04676461
124MYC_18940864_ChIP-ChIP_HL60_Human1.04577182
125FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02681240
126SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02461519
127PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02125400
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02107326
129EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01834453
130RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01834453
131KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01136258
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99982412
133JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99745767
134VDR_21846776_ChIP-Seq_THP-1_Human0.99181692
135TTF2_22483619_ChIP-Seq_HELA_Human0.98837352
136KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97616026
137YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96508825
138ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96312789
139TP53_18474530_ChIP-ChIP_U2OS_Human0.95385344
140* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95300183
141SOX2_16153702_ChIP-ChIP_HESCs_Human0.95288253
142NANOG_18692474_ChIP-Seq_MESCs_Mouse0.95251146
143* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92615185
144SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92325641
145NCOR1_26117541_ChIP-Seq_K562_Human0.91657981
146* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90967513
147KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90821195
148ELK3_25401928_ChIP-Seq_HUVEC_Human0.90414158
149RNF2_27304074_Chip-Seq_ESCs_Mouse0.89199065
150PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.88940425
151RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88595436
152SOX17_20123909_ChIP-Seq_XEN_Mouse0.88472803
153KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87695363
154NANOG_21062744_ChIP-ChIP_HESCs_Human0.87601541
155KDM2B_26808549_Chip-Seq_JURKAT_Human0.87393246
156KAP1_27257070_Chip-Seq_ESCs_Mouse0.86674270
157MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83732157
158KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83200945
159HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82469069
160MAF_26560356_Chip-Seq_TH1_Human0.81984379
161STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79019588
162NANOG_16153702_ChIP-ChIP_HESCs_Human0.78985137
163SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78774089
164GATA6_25053715_ChIP-Seq_YYC3_Human0.78636080
165UTX_26944678_Chip-Seq_JUKART_Human0.78295533
166SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76907769
167BRD4_25478319_ChIP-Seq_HGPS_Human0.76518899
168P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75288253
169RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74420723
170TCF4_18268006_ChIP-ChIP_LS174T_Human0.74161356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology2.71526772
2MP0005076_abnormal_cell_differentiation2.67970095
3MP0010030_abnormal_orbit_morphology2.64493936
4MP0008057_abnormal_DNA_replication2.55492264
5MP0002653_abnormal_ependyma_morphology2.54495354
6MP0010094_abnormal_chromosome_stability2.42897296
7MP0003283_abnormal_digestive_organ2.33582927
8MP0005623_abnormal_meninges_morphology2.14959580
9MP0000778_abnormal_nervous_system2.10612233
10MP0003077_abnormal_cell_cycle2.07497227
11MP0003136_yellow_coat_color2.07196768
12MP0003693_abnormal_embryo_hatching2.03495729
13MP0003121_genomic_imprinting2.00753046
14MP0005257_abnormal_intraocular_pressure2.00321604
15MP0002938_white_spotting1.96534531
16MP0010352_gastrointestinal_tract_polyps1.96149669
17MP0008789_abnormal_olfactory_epithelium1.95640726
18MP0002396_abnormal_hematopoietic_system1.94139851
19MP0002102_abnormal_ear_morphology1.93503031
20MP0004197_abnormal_fetal_growth/weight/1.88867598
21MP0004957_abnormal_blastocyst_morpholog1.86635768
22MP0003941_abnormal_skin_development1.86000027
23MP0009053_abnormal_anal_canal1.84794704
24MP0000566_synostosis1.79692556
25MP0000733_abnormal_muscle_development1.73098089
26* MP0002084_abnormal_developmental_patter1.70994640
27MP0008007_abnormal_cellular_replicative1.70095955
28MP0008058_abnormal_DNA_repair1.66901766
29MP0001293_anophthalmia1.63146750
30MP0000579_abnormal_nail_morphology1.63062520
31MP0002085_abnormal_embryonic_tissue1.62710915
32MP0010307_abnormal_tumor_latency1.60843105
33MP0001529_abnormal_vocalization1.60689852
34MP0003938_abnormal_ear_development1.55484977
35MP0003385_abnormal_body_wall1.55153363
36MP0003705_abnormal_hypodermis_morpholog1.54839999
37MP0003119_abnormal_digestive_system1.54664475
38MP0002697_abnormal_eye_size1.54384457
39MP0008995_early_reproductive_senescence1.52958379
40MP0005499_abnormal_olfactory_system1.52446471
41MP0005394_taste/olfaction_phenotype1.52446471
42MP0004133_heterotaxia1.52015512
43MP0003566_abnormal_cell_adhesion1.51868596
44MP0000350_abnormal_cell_proliferation1.50824083
45MP0003122_maternal_imprinting1.48811175
46MP0001299_abnormal_eye_distance/1.48007959
47MP0002282_abnormal_trachea_morphology1.46044283
48* MP0005380_embryogenesis_phenotype1.44111494
49* MP0001672_abnormal_embryogenesis/_devel1.44111494
50MP0003567_abnormal_fetal_cardiomyocyte1.44063761
51MP0001849_ear_inflammation1.42260710
52MP0009250_abnormal_appendicular_skeleto1.38702044
53MP0005171_absent_coat_pigmentation1.38572050
54MP0002086_abnormal_extraembryonic_tissu1.38234681
55MP0005423_abnormal_somatic_nervous1.37639956
56MP0003828_pulmonary_edema1.36797436
57MP0001915_intracranial_hemorrhage1.35822836
58MP0003937_abnormal_limbs/digits/tail_de1.34937520
59MP0000631_abnormal_neuroendocrine_gland1.34324796
60* MP0003984_embryonic_growth_retardation1.33278533
61MP0000490_abnormal_crypts_of1.33058779
62* MP0002088_abnormal_embryonic_growth/wei1.33046054
63MP0000428_abnormal_craniofacial_morphol1.32551662
64MP0003942_abnormal_urinary_system1.32408183
65MP0001730_embryonic_growth_arrest1.30890751
66MP0008438_abnormal_cutaneous_collagen1.30844375
67MP0005187_abnormal_penis_morphology1.30733546
68MP0003315_abnormal_perineum_morphology1.30260976
69MP0004808_abnormal_hematopoietic_stem1.30034576
70MP0000432_abnormal_head_morphology1.28950055
71MP0002932_abnormal_joint_morphology1.27062884
72MP0002249_abnormal_larynx_morphology1.26666645
73MP0003890_abnormal_embryonic-extraembry1.24681635
74MP0003115_abnormal_respiratory_system1.24173999
75MP0002111_abnormal_tail_morphology1.24038049
76MP0003880_abnormal_central_pattern1.23469331
77MP0008932_abnormal_embryonic_tissue1.23429255
78MP0003123_paternal_imprinting1.21979713
79MP0003935_abnormal_craniofacial_develop1.20293141
80MP0001697_abnormal_embryo_size1.18106944
81MP0001286_abnormal_eye_development1.17828609
82MP0009278_abnormal_bone_marrow1.17555796
83MP0000516_abnormal_urinary_system1.17378187
84MP0005367_renal/urinary_system_phenotyp1.17378187
85MP0002925_abnormal_cardiovascular_devel1.17283316
86MP0006292_abnormal_olfactory_placode1.16494713
87MP0000462_abnormal_digestive_system1.15918943
88MP0001346_abnormal_lacrimal_gland1.14987054
89MP0000537_abnormal_urethra_morphology1.14114931
90MP0003718_maternal_effect1.13561300
91MP0000569_abnormal_digit_pigmentation1.13325312
92MP0002092_abnormal_eye_morphology1.12997365
93MP0005023_abnormal_wound_healing1.11814021
94MP0000762_abnormal_tongue_morphology1.10154463
95MP0000534_abnormal_ureter_morphology1.09343254
96MP0000049_abnormal_middle_ear1.08982664
97MP0001984_abnormal_olfaction1.08433518
98MP0008961_abnormal_basal_metabolism1.08304963
99MP0009384_cardiac_valve_regurgitation1.07239870
100MP0009672_abnormal_birth_weight1.07127609
101MP0005391_vision/eye_phenotype1.06659499
102MP0002751_abnormal_autonomic_nervous1.05609031
103MP0002116_abnormal_craniofacial_bone1.05598263
104MP0000026_abnormal_inner_ear1.03254190
105MP0009703_decreased_birth_body1.01259792
106MP0000383_abnormal_hair_follicle1.01013747
107MP0001177_atelectasis1.00810984
108MP0003755_abnormal_palate_morphology0.99059640
109MP0000647_abnormal_sebaceous_gland0.96373268
110MP0002233_abnormal_nose_morphology0.96333334
111* MP0002080_prenatal_lethality0.94729223
112MP0004185_abnormal_adipocyte_glucose0.93863146
113MP0002234_abnormal_pharynx_morphology0.93524840
114MP0005508_abnormal_skeleton_morphology0.92156129
115* MP0003861_abnormal_nervous_system0.92110072
116MP0005248_abnormal_Harderian_gland0.92079346
117MP0003172_abnormal_lysosome_physiology0.92049274
118MP0009697_abnormal_copulation0.91524278
119MP0006276_abnormal_autonomic_nervous0.91072981
120MP0000955_abnormal_spinal_cord0.90379467
121MP0004272_abnormal_basement_membrane0.89283029
122MP0005503_abnormal_tendon_morphology0.88065539
123MP0006072_abnormal_retinal_apoptosis0.87287917
124MP0002184_abnormal_innervation0.87281380
125MP0003786_premature_aging0.85842435
126MP0002109_abnormal_limb_morphology0.85774441
127MP0002113_abnormal_skeleton_development0.84209973
128MP0002081_perinatal_lethality0.83672803
129MP0005197_abnormal_uvea_morphology0.83387631
130* MP0002152_abnormal_brain_morphology0.82976337
131MP0002752_abnormal_somatic_nervous0.81381380
132MP0003787_abnormal_imprinting0.80255437
133MP0000313_abnormal_cell_death0.80036885
134MP0000767_abnormal_smooth_muscle0.79818243
135MP0002736_abnormal_nociception_after0.78788852
136MP0005195_abnormal_posterior_eye0.75419723
137MP0005253_abnormal_eye_physiology0.75355567
138MP0002177_abnormal_outer_ear0.75041890
139MP0001188_hyperpigmentation0.70397804

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49115273
2Chromsome breakage (HP:0040012)3.36167639
3Urethral obstruction (HP:0000796)3.04207863
4Short 4th metacarpal (HP:0010044)2.93938669
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.93938669
6Amaurosis fugax (HP:0100576)2.90630881
7Abnormal number of incisors (HP:0011064)2.90617373
8Neoplasm of the oral cavity (HP:0100649)2.88202714
9Long eyelashes (HP:0000527)2.84171599
10Ependymoma (HP:0002888)2.68425756
11Cerebral aneurysm (HP:0004944)2.53530771
12Pancreatic fibrosis (HP:0100732)2.52792684
13Shallow orbits (HP:0000586)2.47305315
14Cutaneous finger syndactyly (HP:0010554)2.45647544
15Ectopic kidney (HP:0000086)2.45622334
16Renal duplication (HP:0000075)2.42785079
17Supernumerary ribs (HP:0005815)2.41964725
18Septo-optic dysplasia (HP:0100842)2.40176775
19True hermaphroditism (HP:0010459)2.39548524
20Abnormality of the labia minora (HP:0012880)2.38201949
21Cortical dysplasia (HP:0002539)2.38001987
22Increased nuchal translucency (HP:0010880)2.37311878
23Anal stenosis (HP:0002025)2.28887124
24Abnormal lung lobation (HP:0002101)2.28462061
25Anophthalmia (HP:0000528)2.26376774
26Bifid tongue (HP:0010297)2.25808149
27Medulloblastoma (HP:0002885)2.22881323
28Hyperacusis (HP:0010780)2.21834130
29Preaxial hand polydactyly (HP:0001177)2.21682006
30Abnormality of the nasal septum (HP:0000419)2.19465618
31Pancreatic cysts (HP:0001737)2.18452608
32Skull defect (HP:0001362)2.17536666
33Abnormality of the astrocytes (HP:0100707)2.16726239
34Astrocytoma (HP:0009592)2.16726239
35Cutaneous syndactyly (HP:0012725)2.16533530
36Broad thumb (HP:0011304)2.15732178
37Supernumerary bones of the axial skeleton (HP:0009144)2.15729211
38Rib fusion (HP:0000902)2.14560447
39Vaginal atresia (HP:0000148)2.14160687
40Molar tooth sign on MRI (HP:0002419)2.13826546
41Abnormality of midbrain morphology (HP:0002418)2.13826546
42Genital tract atresia (HP:0001827)2.13345678
43Renal hypoplasia (HP:0000089)2.12494847
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.11768999
45Renovascular hypertension (HP:0100817)2.11593180
46Trigonocephaly (HP:0000243)2.11564505
47Coronal craniosynostosis (HP:0004440)2.11285286
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.10045623
49Vertebral fusion (HP:0002948)2.09096056
50Occipital encephalocele (HP:0002085)2.08408608
51Preaxial foot polydactyly (HP:0001841)2.08243581
52Deviation of the thumb (HP:0009603)2.08121599
53Pseudobulbar signs (HP:0002200)2.07367901
54Abnormality of the fingertips (HP:0001211)2.07131177
55Selective tooth agenesis (HP:0001592)2.04508864
56Abnormal ciliary motility (HP:0012262)2.01969401
57Heterotopia (HP:0002282)2.01522513
58Postaxial foot polydactyly (HP:0001830)2.01376250
59Abnormal respiratory motile cilium physiology (HP:0012261)2.01179086
60Midline defect of the nose (HP:0004122)2.01018601
61Prominent nose (HP:0000448)2.00940735
62Nephronophthisis (HP:0000090)2.00237791
63Genu recurvatum (HP:0002816)1.98113156
64Aplasia/Hypoplasia of the tongue (HP:0010295)1.97603487
65Absent septum pellucidum (HP:0001331)1.97227948
66Bilateral microphthalmos (HP:0007633)1.96967418
67Abnormality of the 4th metacarpal (HP:0010012)1.96760297
68Proximal placement of thumb (HP:0009623)1.96692171
69Elfin facies (HP:0004428)1.95753269
70Oligodactyly (hands) (HP:0001180)1.93616382
71Agnosia (HP:0010524)1.93177847
72Abnormality of abdominal situs (HP:0011620)1.92572457
73Abdominal situs inversus (HP:0003363)1.92572457
74Postaxial hand polydactyly (HP:0001162)1.92232085
75Abnormality of the intervertebral disk (HP:0005108)1.91208096
76Partial duplication of thumb phalanx (HP:0009944)1.91098195
77Anencephaly (HP:0002323)1.91020194
78Myelomeningocele (HP:0002475)1.90887233
79Sclerocornea (HP:0000647)1.90386376
80Spina bifida occulta (HP:0003298)1.90275066
81Oligodactyly (HP:0012165)1.89009464
82Hypoplastic labia majora (HP:0000059)1.88939262
83Hypoplastic pelvis (HP:0008839)1.88904661
84Abnormal respiratory motile cilium morphology (HP:0005938)1.88676700
85Abnormal respiratory epithelium morphology (HP:0012253)1.88676700
86Congenital primary aphakia (HP:0007707)1.88642122
87Mesomelia (HP:0003027)1.88498987
88Oligodontia (HP:0000677)1.88207110
89Gait imbalance (HP:0002141)1.87748628
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.86823952
91Distal lower limb amyotrophy (HP:0008944)1.86482624
92Hepatoblastoma (HP:0002884)1.85872805
93Partial duplication of the phalanx of hand (HP:0009999)1.84776990
94Supernumerary spleens (HP:0009799)1.84408108
95Gastrointestinal atresia (HP:0002589)1.84069688
96Meckel diverticulum (HP:0002245)1.83644323
97Medial flaring of the eyebrow (HP:0010747)1.83621645
98Abnormality of the carotid arteries (HP:0005344)1.83334287
99Labial hypoplasia (HP:0000066)1.81583579
100Facial cleft (HP:0002006)1.80418583
101Abnormality of the septum pellucidum (HP:0007375)1.79969342
102Hemivertebrae (HP:0002937)1.79633092
103Malignant gastrointestinal tract tumors (HP:0006749)1.79341233
104Gastrointestinal carcinoma (HP:0002672)1.79341233
105Glioma (HP:0009733)1.79220152
106Hypoplastic female external genitalia (HP:0012815)1.78295951
107Flat cornea (HP:0007720)1.78152187
108Optic nerve hypoplasia (HP:0000609)1.77511184
109Patellar aplasia (HP:0006443)1.77299853
110Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.76925989
111Rhinitis (HP:0012384)1.76548771
112Triphalangeal thumb (HP:0001199)1.75470845
113Persistence of primary teeth (HP:0006335)1.75337241
114Absent radius (HP:0003974)1.74800699
115Broad phalanges of the hand (HP:0009768)1.73949795
116Colon cancer (HP:0003003)1.73514680
117Protrusio acetabuli (HP:0003179)1.73432044
118Chronic hepatic failure (HP:0100626)1.73173504
119Drooling (HP:0002307)1.72154730
120Syringomyelia (HP:0003396)1.72135461
121Spinal cord lesions (HP:0100561)1.72135461
122Aortic aneurysm (HP:0004942)1.71831879
123Abnormality of the ileum (HP:0001549)1.71374425
124Limited elbow extension (HP:0001377)1.70765017
125Obsessive-compulsive behavior (HP:0000722)1.69219402
126Stenosis of the external auditory canal (HP:0000402)1.68164379
127Patellar dislocation (HP:0002999)1.67519425
128Prostate neoplasm (HP:0100787)1.67470640
129Abnormality of the labia majora (HP:0012881)1.67061749
130Abnormality of the middle phalanges of the toes (HP:0010183)1.66880200
131Ulnar bowing (HP:0003031)1.65959927
132Abnormality of the renal medulla (HP:0100957)1.64847584
133Dynein arm defect of respiratory motile cilia (HP:0012255)1.64729307
134Absent/shortened dynein arms (HP:0200106)1.64729307
135Nephrogenic diabetes insipidus (HP:0009806)1.64028826
136Esophageal atresia (HP:0002032)1.63999929
137Leiomyosarcoma (HP:0100243)1.63046617
138Uterine leiomyosarcoma (HP:0002891)1.63046617
139Dandy-Walker malformation (HP:0001305)1.62303753
140Abnormal sex determination (HP:0012244)1.62230723
141Sex reversal (HP:0012245)1.62230723
142Bladder diverticulum (HP:0000015)1.61894330
143Abnormality of the antihelix (HP:0009738)1.61642713
144Broad finger (HP:0001500)1.61314653
145Narrow palate (HP:0000189)1.61243595
146Broad palm (HP:0001169)1.60482321
147Maternal diabetes (HP:0009800)1.60335347
148Micropenis (HP:0000054)1.60162895
149Morphological abnormality of the middle ear (HP:0008609)1.60075623
150Abnormality of the distal phalanx of the thumb (HP:0009617)1.60023693
151Volvulus (HP:0002580)1.59410603
152Blepharophimosis (HP:0000581)1.58997694
153Aplasia involving forearm bones (HP:0009822)1.58926464
154Absent forearm bone (HP:0003953)1.58926464
155Broad foot (HP:0001769)1.58762269
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.58481804
157Abnormality of the diencephalon (HP:0010662)1.58452873
158Bowel diverticulosis (HP:0005222)1.57392846
159Dental crowding (HP:0000678)1.57135859
160Pendular nystagmus (HP:0012043)1.56927161
161Split foot (HP:0001839)1.56866233
162Cystic liver disease (HP:0006706)1.56700121
163Abnormality of the peritoneum (HP:0002585)1.56504424
164Renal dysplasia (HP:0000110)1.55991943
165Aplasia involving bones of the extremities (HP:0009825)1.55819537
166Aplasia involving bones of the upper limbs (HP:0009823)1.55819537
167Aplasia of the phalanges of the hand (HP:0009802)1.55819537
168Abnormality of the incisor (HP:0000676)1.55650493
169Overriding aorta (HP:0002623)1.55462012
170Tracheoesophageal fistula (HP:0002575)1.55318569
171Wrist flexion contracture (HP:0001239)1.55234572
172Aplasia/Hypoplasia of the patella (HP:0006498)1.54996246
173Holoprosencephaly (HP:0001360)1.54124696
174Duplication of thumb phalanx (HP:0009942)1.54055235
175Intestinal fistula (HP:0100819)1.53941729
176Ankle contracture (HP:0006466)1.53495359
177Hypoplastic ischia (HP:0003175)1.53425210
178Poor coordination (HP:0002370)1.53040308
179Shawl scrotum (HP:0000049)1.53022024
180Chorioretinal coloboma (HP:0000567)1.52978971
181Mitral valve prolapse (HP:0001634)1.52934728

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.78602105
2BRD44.77603559
3EPHA33.77908771
4BUB13.52372678
5EPHA23.29647861
6TNIK2.99961824
7PNCK2.75364166
8CASK2.54171224
9CDC72.51966099
10CAMK1D2.47451750
11EEF2K2.03914778
12WNK31.93957160
13LATS11.90061499
14PBK1.87627168
15MARK11.86085896
16TRIM281.85242637
17CAMK1G1.83207026
18BRSK21.81767628
19SRPK11.81690166
20SIK11.80144839
21MAP3K101.75461285
22NEK21.72922164
23PLK41.72702707
24CDK71.70920569
25SIK21.69918958
26RIPK11.69713812
27BCR1.65241957
28EPHA41.63526669
29ATR1.52566685
30MAP3K41.52136992
31SIK31.46497494
32ERBB21.45894126
33VRK21.40284719
34MKNK11.36772237
35STK38L1.36173378
36TTK1.34879151
37TGFBR21.34745854
38EPHB21.31815075
39DYRK21.31245003
40MTOR1.31024593
41EIF2AK21.29254245
42FGFR21.26256335
43ALK1.24553164
44BMPR1B1.23226005
45STK161.21591204
46RPS6KA41.19365597
47PKN21.18181243
48BRSK11.16043593
49MKNK21.15193812
50ERBB31.14112036
51PASK1.13131638
52ICK1.12902793
53MAP2K71.12110009
54TTN1.08665824
55CDK61.08567686
56NTRK21.08423143
57RPS6KB21.06805266
58CHEK11.04740090
59NEK11.03399558
60MAPK150.99967410
61STK40.99889332
62ERN10.96452069
63PLK20.95597426
64CSNK1G10.92835846
65PAK20.91686061
66STK30.91633609
67CDK40.90965225
68FGFR10.90863186
69CHEK20.89884089
70LATS20.89698208
71NUAK10.87324398
72CHUK0.87310736
73PLK30.87302564
74PAK40.87242362
75AKT20.85535726
76STK390.85000741
77CSNK1G20.84899702
78BMX0.84494923
79MAP3K80.83466546
80ZAK0.83008861
81ATM0.82573351
82STK100.82517169
83NME10.81881269
84CSNK1A1L0.81349814
85CSNK1G30.80602344
86TSSK60.80263288
87PLK10.76969672
88NTRK10.76669505
89CCNB10.75604805
90TAF10.75333985
91TGFBR10.74971336
92CDK20.73334088
93AURKB0.72113807
94DDR20.70606507
95ACVR1B0.70436675
96MAP3K140.70012740
97PTK60.69160713
98PIM10.68578585
99CDK90.67694814
100MAP3K130.67431394
101MINK10.66553542
102CDK30.63893076
103MAPK130.63846145
104CDK80.62826651
105CDK10.60446388
106AKT10.59083833
107KSR10.58576697
108FLT30.58235307
109PAK30.57938663
110PRKCG0.57285096
111UHMK10.56910762
112MAPK140.55458424
113PDGFRA0.54833170
114CAMK40.54100949
115CSNK1D0.53061939
116AURKA0.51349380
117MARK30.51213514
118EIF2AK10.49831825
119CDK180.49736060
120WNK40.49113010
121MAPK10.49040802
122RPS6KL10.48194983
123RPS6KC10.48194983
124PRKDC0.47885644
125NEK90.47160413
126LMTK20.47141871
127PINK10.46696627
128IRAK40.46450453
129INSRR0.46109499
130GRK10.45629037
131CDK150.45581225
132MAP4K20.44964445
133DYRK30.44414130
134MAPK100.43510144
135TBK10.43312195
136PRKCE0.43019371
137LIMK10.42963160
138MET0.42836671
139GSK3B0.42136921
140HCK0.41389875
141RPS6KA20.41148471
142RPS6KA60.40784851
143ERBB40.40656748
144CDK11A0.40180122
145CLK10.39734246
146CDK140.37275677
147RPS6KA10.37112918
148VRK10.37067077
149YES10.37022025
150CSNK1E0.36672904
151MELK0.36400499
152PDK20.36226398
153CDC42BPA0.36092325
154PKN10.35394089
155ITK0.35099785
156DMPK0.33882362
157WEE10.33201832
158IKBKB0.30033444

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.20793238
2Mismatch repair_Homo sapiens_hsa034302.18689761
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14306765
4Notch signaling pathway_Homo sapiens_hsa043302.09048809
5One carbon pool by folate_Homo sapiens_hsa006702.03986598
6Spliceosome_Homo sapiens_hsa030402.03934928
7mRNA surveillance pathway_Homo sapiens_hsa030152.01140567
8DNA replication_Homo sapiens_hsa030301.99749933
9Cell cycle_Homo sapiens_hsa041101.97534507
10MicroRNAs in cancer_Homo sapiens_hsa052061.94108294
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.89472401
12Protein export_Homo sapiens_hsa030601.88824368
13Steroid biosynthesis_Homo sapiens_hsa001001.88742399
14Proteasome_Homo sapiens_hsa030501.84461461
15Lysine degradation_Homo sapiens_hsa003101.78572833
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75371852
17RNA transport_Homo sapiens_hsa030131.74923606
18Homologous recombination_Homo sapiens_hsa034401.74658508
19Small cell lung cancer_Homo sapiens_hsa052221.63643916
20Adherens junction_Homo sapiens_hsa045201.59881251
21Hippo signaling pathway_Homo sapiens_hsa043901.56010711
22Huntingtons disease_Homo sapiens_hsa050161.53152045
23Fanconi anemia pathway_Homo sapiens_hsa034601.52128982
24Herpes simplex infection_Homo sapiens_hsa051681.50000934
25Chronic myeloid leukemia_Homo sapiens_hsa052201.49819230
26Parkinsons disease_Homo sapiens_hsa050121.49660698
27p53 signaling pathway_Homo sapiens_hsa041151.47421107
28Propanoate metabolism_Homo sapiens_hsa006401.47274043
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.46814986
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.43175197
31Oxidative phosphorylation_Homo sapiens_hsa001901.42991294
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42136164
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40679119
34HTLV-I infection_Homo sapiens_hsa051661.40556825
35TGF-beta signaling pathway_Homo sapiens_hsa043501.37042070
36Hedgehog signaling pathway_Homo sapiens_hsa043401.34419534
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30803192
38Non-homologous end-joining_Homo sapiens_hsa034501.25865793
39Ribosome_Homo sapiens_hsa030101.25592253
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19997633
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19586190
42Pyruvate metabolism_Homo sapiens_hsa006201.18475804
43Proteoglycans in cancer_Homo sapiens_hsa052051.16594097
44Viral carcinogenesis_Homo sapiens_hsa052031.16115504
45Base excision repair_Homo sapiens_hsa034101.13579596
46Colorectal cancer_Homo sapiens_hsa052101.13088461
47ECM-receptor interaction_Homo sapiens_hsa045121.10783038
48RNA degradation_Homo sapiens_hsa030181.10720888
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.10339156
50Nucleotide excision repair_Homo sapiens_hsa034201.09890323
51Osteoclast differentiation_Homo sapiens_hsa043801.09228937
52Oocyte meiosis_Homo sapiens_hsa041141.08667390
53Nicotine addiction_Homo sapiens_hsa050331.07195853
54Leishmaniasis_Homo sapiens_hsa051401.06664624
55Axon guidance_Homo sapiens_hsa043601.03893652
56Systemic lupus erythematosus_Homo sapiens_hsa053221.00676574
57Pathways in cancer_Homo sapiens_hsa052001.00237675
58TNF signaling pathway_Homo sapiens_hsa046680.99644351
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99041776
60* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98769471
61Wnt signaling pathway_Homo sapiens_hsa043100.98702452
62mTOR signaling pathway_Homo sapiens_hsa041500.98437101
63Cardiac muscle contraction_Homo sapiens_hsa042600.97809302
64Pancreatic cancer_Homo sapiens_hsa052120.97752156
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96793163
66Melanogenesis_Homo sapiens_hsa049160.96746597
67Hepatitis B_Homo sapiens_hsa051610.96687341
68Apoptosis_Homo sapiens_hsa042100.96363776
69Alzheimers disease_Homo sapiens_hsa050100.94264871
70Viral myocarditis_Homo sapiens_hsa054160.94010685
71Prostate cancer_Homo sapiens_hsa052150.90351615
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90070568
73Epstein-Barr virus infection_Homo sapiens_hsa051690.89976358
74Pyrimidine metabolism_Homo sapiens_hsa002400.89928974
75Influenza A_Homo sapiens_hsa051640.88560942
76Focal adhesion_Homo sapiens_hsa045100.87832555
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87293063
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87222061
79Amoebiasis_Homo sapiens_hsa051460.87033799
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85851018
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84919719
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84450603
83Biosynthesis of amino acids_Homo sapiens_hsa012300.84161140
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82665551
85Folate biosynthesis_Homo sapiens_hsa007900.82518291
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82434958
87Bladder cancer_Homo sapiens_hsa052190.82421682
88Endometrial cancer_Homo sapiens_hsa052130.81996955
89Selenocompound metabolism_Homo sapiens_hsa004500.81779607
90Hematopoietic cell lineage_Homo sapiens_hsa046400.81374458
91Melanoma_Homo sapiens_hsa052180.80250273
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79922980
93Toxoplasmosis_Homo sapiens_hsa051450.79699474
94Acute myeloid leukemia_Homo sapiens_hsa052210.78602983
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78518365
96Fatty acid elongation_Homo sapiens_hsa000620.76684327
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76398779
98Basal transcription factors_Homo sapiens_hsa030220.76390888
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75904164
100Phototransduction_Homo sapiens_hsa047440.75757175
101Measles_Homo sapiens_hsa051620.75417940
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.73228563
103Cocaine addiction_Homo sapiens_hsa050300.73203562
104Purine metabolism_Homo sapiens_hsa002300.73136333
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72279304
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.72137178
107RNA polymerase_Homo sapiens_hsa030200.71567406
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70686219
109Legionellosis_Homo sapiens_hsa051340.70659540
110B cell receptor signaling pathway_Homo sapiens_hsa046620.70586989
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69120190
112HIF-1 signaling pathway_Homo sapiens_hsa040660.68823364
113Butanoate metabolism_Homo sapiens_hsa006500.68075144
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67649631
115FoxO signaling pathway_Homo sapiens_hsa040680.65837901
116Renal cell carcinoma_Homo sapiens_hsa052110.65822627
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.63796778
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63108124
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62823381
120Dorso-ventral axis formation_Homo sapiens_hsa043200.62381459
121Non-small cell lung cancer_Homo sapiens_hsa052230.61896409
122Antigen processing and presentation_Homo sapiens_hsa046120.61849510
123Malaria_Homo sapiens_hsa051440.61699055
124Tight junction_Homo sapiens_hsa045300.61345469
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59728728
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.59014266
127Sulfur relay system_Homo sapiens_hsa041220.57838429
128Type II diabetes mellitus_Homo sapiens_hsa049300.57098285
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56595679
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55864527
131Nitrogen metabolism_Homo sapiens_hsa009100.55261084
132Gap junction_Homo sapiens_hsa045400.55126112
133Protein digestion and absorption_Homo sapiens_hsa049740.54742415
134Tuberculosis_Homo sapiens_hsa051520.54439179
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53855725
136Glutathione metabolism_Homo sapiens_hsa004800.53732925
137Vitamin B6 metabolism_Homo sapiens_hsa007500.53598053
138Asthma_Homo sapiens_hsa053100.52885588
139Rap1 signaling pathway_Homo sapiens_hsa040150.52171904
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51840322
141Glioma_Homo sapiens_hsa052140.51831036
142Arginine and proline metabolism_Homo sapiens_hsa003300.51021522
143Salmonella infection_Homo sapiens_hsa051320.49250690
144Taste transduction_Homo sapiens_hsa047420.48885982
145Carbon metabolism_Homo sapiens_hsa012000.48431423
146Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47825622
147beta-Alanine metabolism_Homo sapiens_hsa004100.47519398
148Dilated cardiomyopathy_Homo sapiens_hsa054140.46386964
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46329838
150Dopaminergic synapse_Homo sapiens_hsa047280.45798281
151Metabolic pathways_Homo sapiens_hsa011000.45234110
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39383319
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38934450
154Retinol metabolism_Homo sapiens_hsa008300.38739290
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38377948
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37844618
157Alcoholism_Homo sapiens_hsa050340.36869346
158Fatty acid metabolism_Homo sapiens_hsa012120.35143916
159Primary bile acid biosynthesis_Homo sapiens_hsa001200.33353361
160Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32813191
161Glutamatergic synapse_Homo sapiens_hsa047240.31889153

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