MID1IP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.99707904
2axon ensheathment in central nervous system (GO:0032291)4.15873270
3central nervous system myelination (GO:0022010)4.15873270
43-UTR-mediated mRNA stabilization (GO:0070935)3.90924864
5alpha-linolenic acid metabolic process (GO:0036109)3.87050782
6negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.84949653
7fatty acid elongation (GO:0030497)3.62121981
8regulation of cholesterol biosynthetic process (GO:0045540)3.54186776
9focal adhesion assembly (GO:0048041)3.49882136
10cell-substrate adherens junction assembly (GO:0007045)3.49882136
11mannose metabolic process (GO:0006013)3.46453290
12apoptotic process involved in morphogenesis (GO:0060561)3.45486865
13epithelial cell differentiation involved in prostate gland development (GO:0060742)3.43195125
14acyl-CoA biosynthetic process (GO:0071616)3.39467562
15thioester biosynthetic process (GO:0035384)3.39467562
16long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.39355965
17embryonic process involved in female pregnancy (GO:0060136)3.39321189
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.37246197
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.37246197
20modulation by symbiont of host immune response (GO:0052553)3.37246197
21positive regulation by symbiont of host defense response (GO:0052509)3.37246197
22modulation by symbiont of host defense response (GO:0052031)3.37246197
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.37246197
24proline biosynthetic process (GO:0006561)3.36080795
25pentose-phosphate shunt (GO:0006098)3.32329769
26adherens junction assembly (GO:0034333)3.31153140
27fatty-acyl-CoA biosynthetic process (GO:0046949)3.29541288
28very long-chain fatty acid metabolic process (GO:0000038)3.22383493
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.22156519
30L-phenylalanine catabolic process (GO:0006559)3.22156519
31surfactant homeostasis (GO:0043129)3.22016782
32ethanol oxidation (GO:0006069)3.20269810
33response to muramyl dipeptide (GO:0032495)3.19156960
34regulation of amyloid precursor protein catabolic process (GO:1902991)3.18515976
35myelin maintenance (GO:0043217)3.17549581
36response to laminar fluid shear stress (GO:0034616)3.15938257
37response to peptidoglycan (GO:0032494)3.15692849
38creatine metabolic process (GO:0006600)3.15677462
39regulation of NFAT protein import into nucleus (GO:0051532)3.14081337
40negative regulation of toll-like receptor signaling pathway (GO:0034122)3.13412653
41regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.10431147
42L-phenylalanine metabolic process (GO:0006558)3.10337438
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.10337438
44regulation of mammary gland epithelial cell proliferation (GO:0033599)3.05945081
45maternal placenta development (GO:0001893)3.05653849
46negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.02681163
47regulation of chromatin binding (GO:0035561)3.01911763
48regulation of early endosome to late endosome transport (GO:2000641)3.00122532
49regulation of cholesterol metabolic process (GO:0090181)2.99015309
50glycine transport (GO:0015816)2.96340373
51positive regulation of triglyceride biosynthetic process (GO:0010867)2.95772085
52intracellular estrogen receptor signaling pathway (GO:0030520)2.95134260
53RNA stabilization (GO:0043489)2.93019753
54mRNA stabilization (GO:0048255)2.93019753
55low-density lipoprotein particle clearance (GO:0034383)2.91063095
56cellular protein complex localization (GO:0034629)2.89468210
57positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.87542426
58protein complex localization (GO:0031503)2.87410803
59positive regulation of macrophage cytokine production (GO:0060907)2.86137223
60cholesterol catabolic process (GO:0006707)2.85877619
61sterol catabolic process (GO:0016127)2.85877619
62fatty-acyl-CoA metabolic process (GO:0035337)2.85680321
63positive regulation of myotube differentiation (GO:0010831)2.85627608
64regulation of beta-amyloid formation (GO:1902003)2.85042102
65negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.84407038
66NADPH regeneration (GO:0006740)2.84320667
67triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.84249701
68response to methylmercury (GO:0051597)2.83522059
69negative regulation of response to reactive oxygen species (GO:1901032)2.82989140
70regulation of cholesterol homeostasis (GO:2000188)2.82671502
71potassium ion import (GO:0010107)2.82597025
72cellular response to cholesterol (GO:0071397)2.80173930
73aspartate family amino acid catabolic process (GO:0009068)2.78390235
74long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.76158019
75NADH metabolic process (GO:0006734)2.73114097
76activation of Rac GTPase activity (GO:0032863)2.71008927
77regulation of hydrogen peroxide-induced cell death (GO:1903205)2.67458311
78regulation of ARF protein signal transduction (GO:0032012)2.67259520
79positive thymic T cell selection (GO:0045059)2.66912372
80activation of MAPKKK activity (GO:0000185)2.66290575
81dicarboxylic acid catabolic process (GO:0043649)2.66042336
82negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.65760793
83histone H3-K36 demethylation (GO:0070544)2.64151627
84sodium ion export (GO:0071436)2.63948491
85intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.63012838
86cellular hyperosmotic response (GO:0071474)2.61780555
87positive regulation of protein dephosphorylation (GO:0035307)2.60975457
88stress fiber assembly (GO:0043149)2.60339224
89modulation by virus of host process (GO:0019054)2.60220957
90glucose catabolic process (GO:0006007)2.57880997
91regulation of glucose import in response to insulin stimulus (GO:2001273)2.57856183
92positive regulation of histone deacetylation (GO:0031065)2.55707221
93ethanol metabolic process (GO:0006067)2.55119557
94cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.53611573
95planar cell polarity pathway involved in neural tube closure (GO:0090179)2.53412340
96regulation of macrophage cytokine production (GO:0010935)2.53294125
97peptidyl-tyrosine autophosphorylation (GO:0038083)2.53262087
98negative regulation of myotube differentiation (GO:0010832)2.52694848
99sulfur amino acid catabolic process (GO:0000098)2.52679277
100modulation by symbiont of host cellular process (GO:0044068)2.51504589
101positive regulation of gamma-delta T cell activation (GO:0046645)2.51290733
102positive regulation of triglyceride metabolic process (GO:0090208)2.51248138
103regulation of triglyceride biosynthetic process (GO:0010866)2.51173470
104detection of other organism (GO:0098543)2.51087464
105acetyl-CoA metabolic process (GO:0006084)2.50320661
106regulation of translational fidelity (GO:0006450)2.50312418
107DNA unwinding involved in DNA replication (GO:0006268)2.49622830
108negative regulation of skeletal muscle tissue development (GO:0048642)2.49183508
109cellular potassium ion homeostasis (GO:0030007)2.48974693
110short-chain fatty acid metabolic process (GO:0046459)2.47502276
111positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.46972125
112positive regulation of cellular amide metabolic process (GO:0034250)2.46766400
113negative regulation of necroptotic process (GO:0060546)2.46756925
114chemical homeostasis within a tissue (GO:0048875)2.46746299
115glucose 6-phosphate metabolic process (GO:0051156)2.45623773
116detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.44794816
117detection of temperature stimulus involved in sensory perception (GO:0050961)2.44794816
118positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.43887923
119cell communication by electrical coupling (GO:0010644)2.43653920
120fatty acid beta-oxidation (GO:0006635)2.43370021
121negative regulation of cell size (GO:0045792)2.43329930
122regulation of response to osmotic stress (GO:0047484)2.42905819
123detection of bacterium (GO:0016045)2.40651675
124negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.40509006
125negative regulation of cell killing (GO:0031342)2.40509006
126regulation of lipoprotein metabolic process (GO:0050746)2.40438662
127acyl-CoA metabolic process (GO:0006637)2.40192295
128thioester metabolic process (GO:0035383)2.40192295
129ensheathment of neurons (GO:0007272)2.39657144
130axon ensheathment (GO:0008366)2.39657144
131barbed-end actin filament capping (GO:0051016)2.38252654
132low-density lipoprotein particle remodeling (GO:0034374)2.37794272
133positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.37487667
134thymic T cell selection (GO:0045061)2.36674539
135negative regulation of striated muscle cell differentiation (GO:0051154)2.35760214
136myelination (GO:0042552)2.35385014
137cellular modified amino acid catabolic process (GO:0042219)2.35303280
138regulation of autophagic vacuole assembly (GO:2000785)2.34184606
139cell communication involved in cardiac conduction (GO:0086065)2.34167092
140reverse cholesterol transport (GO:0043691)2.33731580
141macrophage activation involved in immune response (GO:0002281)2.33573672
142tricarboxylic acid metabolic process (GO:0072350)2.33100009
143fatty acid homeostasis (GO:0055089)2.32479071
144triglyceride biosynthetic process (GO:0019432)2.32460623
145fatty acid catabolic process (GO:0009062)2.30651855
146negative regulation of potassium ion transmembrane transport (GO:1901380)2.30558472
147coenzyme catabolic process (GO:0009109)2.30358146
148cholesterol biosynthetic process (GO:0006695)2.30193367
149proline metabolic process (GO:0006560)2.29876793
150response to dietary excess (GO:0002021)2.29768659
151cellular response to sterol (GO:0036315)2.29585851
152macroautophagy (GO:0016236)2.29176130
153cysteine metabolic process (GO:0006534)2.28811290
154regulation of membrane repolarization (GO:0060306)2.28661386
155regulation of necrotic cell death (GO:0010939)2.28292452
156alanine transport (GO:0032328)2.28247394
157regulation of cholesterol esterification (GO:0010872)2.27168847
158protein localization to endosome (GO:0036010)2.26904553
159acylglycerol biosynthetic process (GO:0046463)2.26727442
160neutral lipid biosynthetic process (GO:0046460)2.26727442
161mRNA transcription from RNA polymerase II promoter (GO:0042789)2.26339387
162positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.25831784
163peptidyl-arginine omega-N-methylation (GO:0035247)2.25762054
164mitochondrial DNA metabolic process (GO:0032042)2.25660572
165modulation by virus of host morphology or physiology (GO:0019048)2.25511981
166regulation of gamma-delta T cell activation (GO:0046643)2.24729746
167negative regulation of protein localization to cell surface (GO:2000009)2.23920575
168monosaccharide biosynthetic process (GO:0046364)2.23712412
169retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.22579881
170response to mercury ion (GO:0046689)2.22389741
171fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.22053587
172membrane repolarization (GO:0086009)2.22013709
173cytoskeletal anchoring at plasma membrane (GO:0007016)2.21263939
174establishment of mitochondrion localization (GO:0051654)2.21117542
175positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.21083432
176cell-substrate junction assembly (GO:0007044)2.20982108
177lipid oxidation (GO:0034440)2.20177973
178skeletal muscle contraction (GO:0003009)2.18498784
179high-density lipoprotein particle remodeling (GO:0034375)2.18492735
180negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.17673320
181heterochromatin organization (GO:0070828)2.17298819
182positive regulation of Cdc42 GTPase activity (GO:0043089)2.16973875
183oligodendrocyte differentiation (GO:0048709)2.16554858
184glutamate metabolic process (GO:0006536)2.16388752
185fatty acid oxidation (GO:0019395)2.14954112
186L-serine transport (GO:0015825)2.14761365
187detection of temperature stimulus (GO:0016048)2.14041218
188linoleic acid metabolic process (GO:0043651)2.13595914
189protein-lipid complex assembly (GO:0065005)2.13292868
190plasma lipoprotein particle clearance (GO:0034381)2.12454622
191positive regulation of potassium ion transmembrane transport (GO:1901381)2.12166441
192monocarboxylic acid catabolic process (GO:0072329)2.12042984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.27061745
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.61833749
3* VDR_21846776_ChIP-Seq_THP-1_Human3.41789801
4MYC_22102868_ChIP-Seq_BL_Human3.28261761
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.95255692
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.73057090
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60497223
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.59892808
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.58991149
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.51481917
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42655842
12TCF7_22412390_ChIP-Seq_EML_Mouse2.36584278
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.30919252
14* ESR2_21235772_ChIP-Seq_MCF-7_Human2.23857485
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19042602
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.09130942
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.01667411
18* VDR_24763502_ChIP-Seq_THP-1_Human1.97785119
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.84769257
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82539713
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.81965100
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.81776407
23CLOCK_20551151_ChIP-Seq_293T_Human1.81228884
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80760683
25LXR_22292898_ChIP-Seq_THP-1_Human1.78980315
26* MAF_26560356_Chip-Seq_TH1_Human1.78852773
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75773433
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.74885190
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.70235258
30KDM2B_26808549_Chip-Seq_JURKAT_Human1.64906424
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.62489174
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62388809
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58732569
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58403503
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57653987
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53473833
37CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51744584
38UTX_26944678_Chip-Seq_JUKART_Human1.50713850
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50088801
40ZNF263_19887448_ChIP-Seq_K562_Human1.49155128
41MAF_26560356_Chip-Seq_TH2_Human1.48820501
42E2F7_22180533_ChIP-Seq_HELA_Human1.44206251
43GATA1_19941826_ChIP-Seq_K562_Human1.41234892
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41172613
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40557373
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40295237
47KDM2B_26808549_Chip-Seq_K562_Human1.39480151
48RACK7_27058665_Chip-Seq_MCF-7_Human1.39065846
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38983168
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38977730
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38045849
52* RUNX1_22412390_ChIP-Seq_EML_Mouse1.37251209
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.36798551
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36607429
55TBX20_22328084_ChIP-Seq_HEART_Mouse1.36558880
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.36558880
57* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36460693
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36087249
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35686679
60* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34657530
61* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34470286
62DROSHA_22980978_ChIP-Seq_HELA_Human1.34106375
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34045290
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32973438
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.32885357
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32661464
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32507830
68NCOR1_26117541_ChIP-Seq_K562_Human1.32376384
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32074325
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.27590523
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27435131
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27023289
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26109144
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26037889
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25552495
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25490283
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24614135
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24614135
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24366023
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21413654
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.20630443
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20125511
83FOXA2_19822575_ChIP-Seq_HepG2_Human1.19864411
84* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19855544
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19117462
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18204398
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17483855
88RARB_27405468_Chip-Seq_BRAIN_Mouse1.17459951
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17380792
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14374440
91* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13872072
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13863195
93ATF3_27146783_Chip-Seq_COLON_Human1.13657849
94CTCF_27219007_Chip-Seq_Bcells_Human1.11390166
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11212470
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.10734856
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10571677
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10210265
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09896605
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09608834
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08482853
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07161146
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.06125489
104FOXM1_23109430_ChIP-Seq_U2OS_Human1.06100720
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06048490
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05842677
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.05744708
108MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05131734
109GATA1_22025678_ChIP-Seq_K562_Human1.04864321
110* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03641270
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03363206
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03210543
113P68_20966046_ChIP-Seq_HELA_Human1.02852138
114P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02439326
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01887037
116AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01203765
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01045659
118BCOR_27268052_Chip-Seq_Bcells_Human1.00988935
119* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00842286
120RUNX1_27514584_Chip-Seq_MCF-7_Human0.99964773
121SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99917570
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99290117
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.99100045
124TP63_22573176_ChIP-Seq_HFKS_Human0.97452858
125TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97444858
126RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97359713
127TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97329695
128SCL_19346495_ChIP-Seq_HPC-7_Human0.96791880
129* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96008437
130P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95862764
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95073637
132KDM2B_26808549_Chip-Seq_DND41_Human0.94503673
133TET1_21490601_ChIP-Seq_MESCs_Mouse0.93665061
134CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93583192
135CTCF_21964334_Chip-Seq_Bcells_Human0.93540985
136STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93348159
137GATA1_19941827_ChIP-Seq_MEL_Mouse0.92755874
138SA1_27219007_Chip-Seq_Bcells_Human0.92627042
139* XRN2_22483619_ChIP-Seq_HELA_Human0.92499020
140MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92012313
141ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91396114
142* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90369610
143RNF2_27304074_Chip-Seq_ESCs_Mouse0.90278086
144* CREB1_26743006_Chip-Seq_LNCaP_Human0.90264430
145* SOX2_20726797_ChIP-Seq_SW620_Human0.89769516
146CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89628179
147WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89239684
148* GATA2_19941826_ChIP-Seq_K562_Human0.89231691
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88925285
150ESR1_21235772_ChIP-Seq_MCF-7_Human0.88883875
151SMC4_20622854_ChIP-Seq_HELA_Human0.88793950
152IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88038511
153PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87868508
154ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86246597
155CTCF_20526341_ChIP-Seq_ESCs_Human0.86089290
156REST_18959480_ChIP-ChIP_MESCs_Mouse0.85883554
157SA1_27219007_Chip-Seq_ERYTHROID_Human0.85653875
158EED_16625203_ChIP-ChIP_MESCs_Mouse0.84279191
159MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83811368
160GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83288654
161BCL6_27268052_Chip-Seq_Bcells_Human0.83069401
162JARID2_20064375_ChIP-Seq_MESCs_Mouse0.82750709
163CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81727744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell3.86662038
2MP0005451_abnormal_body_composition3.69764864
3MP0003329_amyloid_beta_deposits3.60273964
4MP0005083_abnormal_biliary_tract3.14648112
5MP0005076_abnormal_cell_differentiation3.06452699
6MP0002139_abnormal_hepatobiliary_system2.95378698
7MP0002837_dystrophic_cardiac_calcinosis2.89113620
8MP0009278_abnormal_bone_marrow2.66869505
9MP0003806_abnormal_nucleotide_metabolis2.45965950
10MP0003303_peritoneal_inflammation2.44648990
11MP0003690_abnormal_glial_cell2.34459387
12MP0000604_amyloidosis2.32651787
13MP0005058_abnormal_lysosome_morphology2.27241591
14MP0000751_myopathy2.26242628
15MP0004233_abnormal_muscle_weight2.25898098
16MP0004858_abnormal_nervous_system2.21362603
17MP0003436_decreased_susceptibility_to2.19107194
18MP0000920_abnormal_myelination2.18212858
19MP0008260_abnormal_autophagy2.11344276
20MP0005085_abnormal_gallbladder_physiolo2.06595369
21MP0002909_abnormal_adrenal_gland2.03001005
22MP0001849_ear_inflammation2.01277934
23MP0008875_abnormal_xenobiotic_pharmacok2.00633453
24MP0009672_abnormal_birth_weight1.99870258
25MP0005365_abnormal_bile_salt1.95875242
26MP0004270_analgesia1.91045611
27MP0004036_abnormal_muscle_relaxation1.84802491
28MP0004782_abnormal_surfactant_physiolog1.82304447
29MP0000749_muscle_degeneration1.75407293
30MP0003191_abnormal_cellular_cholesterol1.70167772
31MP0003075_altered_response_to1.67645054
32MP0005360_urolithiasis1.66170513
33MP0003634_abnormal_glial_cell1.63797288
34MP0001958_emphysema1.63591580
35MP0004130_abnormal_muscle_cell1.61597153
36MP0010329_abnormal_lipoprotein_level1.60911314
37MP0000747_muscle_weakness1.60644634
38MP0002118_abnormal_lipid_homeostasis1.59462868
39MP0002249_abnormal_larynx_morphology1.59395367
40MP0003453_abnormal_keratinocyte_physiol1.57860203
41MP0004947_skin_inflammation1.56515138
42MP0002009_preneoplasia1.53885344
43MP0000750_abnormal_muscle_regeneration1.50889897
44MP0003195_calcinosis1.50352637
45MP0005332_abnormal_amino_acid1.49738307
46MP0004084_abnormal_cardiac_muscle1.49285162
47MP0000685_abnormal_immune_system1.47285740
48MP0002733_abnormal_thermal_nociception1.46123203
49MP0005167_abnormal_blood-brain_barrier1.45590488
50MP0004043_abnormal_pH_regulation1.45448289
51MP0004885_abnormal_endolymph1.43659676
52MP0000678_abnormal_parathyroid_gland1.42969583
53MP0003656_abnormal_erythrocyte_physiolo1.42098457
54MP0002396_abnormal_hematopoietic_system1.41414652
55MP0000013_abnormal_adipose_tissue1.40176510
56MP0003633_abnormal_nervous_system1.35082559
57MP0010630_abnormal_cardiac_muscle1.32326841
58MP0003828_pulmonary_edema1.31729165
59MP0002877_abnormal_melanocyte_morpholog1.30288448
60MP0003950_abnormal_plasma_membrane1.28462651
61MP0003091_abnormal_cell_migration1.28406495
62MP0004215_abnormal_myocardial_fiber1.27929124
63MP0002971_abnormal_brown_adipose1.26344838
64MP0010234_abnormal_vibrissa_follicle1.24242045
65MP0002419_abnormal_innate_immunity1.23201000
66MP0009780_abnormal_chondrocyte_physiolo1.22108485
67MP0005584_abnormal_enzyme/coenzyme_acti1.21758944
68MP0000858_altered_metastatic_potential1.20259056
69MP0000733_abnormal_muscle_development1.19434108
70MP0003137_abnormal_impulse_conducting1.19002072
71MP0005330_cardiomyopathy1.18375219
72MP0002735_abnormal_chemical_nociception1.16552214
73MP0004808_abnormal_hematopoietic_stem1.16317844
74MP0002089_abnormal_postnatal_growth/wei1.15894226
75MP0003221_abnormal_cardiomyocyte_apopto1.15798944
76MP0003646_muscle_fatigue1.13938732
77MP0003183_abnormal_peptide_metabolism1.13314708
78MP0005623_abnormal_meninges_morphology1.13263709
79MP0001346_abnormal_lacrimal_gland1.12176241
80MP0004087_abnormal_muscle_fiber1.12103740
81MP0008004_abnormal_stomach_pH1.11644566
82MP0001970_abnormal_pain_threshold1.11076933
83MP0002972_abnormal_cardiac_muscle1.10221869
84MP0003631_nervous_system_phenotype1.09733676
85MP0002295_abnormal_pulmonary_circulatio1.09293838
86MP0002090_abnormal_vision1.08724825
87MP0001666_abnormal_nutrient_absorption1.08412505
88MP0001348_abnormal_lacrimal_gland1.06912401
89MP0002269_muscular_atrophy1.04876796
90MP0002132_abnormal_respiratory_system1.04652982
91MP0005165_increased_susceptibility_to1.04263344
92MP0005670_abnormal_white_adipose1.04260348
93MP0003763_abnormal_thymus_physiology1.02203266
94MP0004859_abnormal_synaptic_plasticity1.01473385
95MP0005025_abnormal_response_to1.01113571
96MP0003632_abnormal_nervous_system1.00845305
97MP0000003_abnormal_adipose_tissue1.00305631
98MP0000703_abnormal_thymus_morphology0.98796288
99MP0001730_embryonic_growth_arrest0.97895817
100MP0002796_impaired_skin_barrier0.97796808
101MP0003279_aneurysm0.97100824
102MP0009333_abnormal_splenocyte_physiolog0.95980261
103MP0002254_reproductive_system_inflammat0.95519445
104MP0003252_abnormal_bile_duct0.95219812
105MP0000343_altered_response_to0.93837203
106MP0008569_lethality_at_weaning0.93043830
107MP0004381_abnormal_hair_follicle0.92871591
108MP0002998_abnormal_bone_remodeling0.92696836
109MP0002272_abnormal_nervous_system0.92417429
110MP0002734_abnormal_mechanical_nocicepti0.92230126
111MP0000639_abnormal_adrenal_gland0.90526869
112MP0002229_neurodegeneration0.89899093
113MP0002398_abnormal_bone_marrow0.89611042
114MP0000350_abnormal_cell_proliferation0.88522981
115MP0001177_atelectasis0.88314308
116MP0005166_decreased_susceptibility_to0.88183919
117MP0003172_abnormal_lysosome_physiology0.87982813
118MP0005620_abnormal_muscle_contractility0.86873789
119MP0002106_abnormal_muscle_physiology0.86629480
120MP0003300_gastrointestinal_ulcer0.86382450
121MP0000490_abnormal_crypts_of0.86073825
122MP0002064_seizures0.85607275
123MP0004185_abnormal_adipocyte_glucose0.85441241
124MP0004145_abnormal_muscle_electrophysio0.85214759
125MP0001545_abnormal_hematopoietic_system0.85028866
126MP0005397_hematopoietic_system_phenotyp0.85028866
127MP0005000_abnormal_immune_tolerance0.84262289
128MP0005375_adipose_tissue_phenotype0.83857447
129MP0005621_abnormal_cell_physiology0.83593896
130MP0001968_abnormal_touch/_nociception0.81458855
131MP0009643_abnormal_urine_homeostasis0.81240728
132MP0002166_altered_tumor_susceptibility0.79328394
133MP0001790_abnormal_immune_system0.78789659
134MP0005387_immune_system_phenotype0.78789659
135MP0000579_abnormal_nail_morphology0.78527107
136MP0002420_abnormal_adaptive_immunity0.78204249
137MP0003111_abnormal_nucleus_morphology0.78184524
138MP0003635_abnormal_synaptic_transmissio0.77950407
139MP0001819_abnormal_immune_cell0.77927585
140MP0003705_abnormal_hypodermis_morpholog0.77803305
141MP0006138_congestive_heart_failure0.77617597
142MP0000609_abnormal_liver_physiology0.77267375
143MP0005385_cardiovascular_system_phenoty0.76847353
144MP0001544_abnormal_cardiovascular_syste0.76847353
145MP0002736_abnormal_nociception_after0.76841548
146MP0001533_abnormal_skeleton_physiology0.76519102
147MP0002078_abnormal_glucose_homeostasis0.76496787
148MP0006036_abnormal_mitochondrial_physio0.76113477
149MP0004510_myositis0.75679856
150MP0002722_abnormal_immune_system0.74460812
151MP0004142_abnormal_muscle_tone0.74341735
152MP0004085_abnormal_heartbeat0.74313694
153MP0001502_abnormal_circadian_rhythm0.73747927
154MP0001800_abnormal_humoral_immune0.71614791
155MP0004264_abnormal_extraembryonic_tissu0.71274396
156MP0002970_abnormal_white_adipose0.71193640
157MP0001664_abnormal_digestion0.71186427
158MP0001299_abnormal_eye_distance/0.71172811
159MP0005388_respiratory_system_phenotype0.70877935
160MP0002133_abnormal_respiratory_system0.70877935
161MP0003566_abnormal_cell_adhesion0.70862018
162MP0003984_embryonic_growth_retardation0.70792505
163MP0005501_abnormal_skin_physiology0.70475128
164MP0005666_abnormal_adipose_tissue0.70471615
165MP0000759_abnormal_skeletal_muscle0.70088762
166MP0002080_prenatal_lethality0.69028464
167MP0005334_abnormal_fat_pad0.68670611
168MP0002723_abnormal_immune_serum0.68092622

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.33181998
2Cerebral inclusion bodies (HP:0100314)4.23641406
3Centrally nucleated skeletal muscle fibers (HP:0003687)3.83518917
4Supranuclear gaze palsy (HP:0000605)3.60917802
5Megalencephaly (HP:0001355)3.59495964
6Myopathic facies (HP:0002058)3.42933952
7Hyperacusis (HP:0010780)3.42416179
8Xanthomatosis (HP:0000991)3.40121711
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.29127731
10Distal lower limb muscle weakness (HP:0009053)3.27350151
11Abnormality of skeletal muscle fiber size (HP:0012084)3.25454027
12Hyporeflexia of lower limbs (HP:0002600)3.12928632
13Muscle fiber inclusion bodies (HP:0100299)3.05386698
14Ketoacidosis (HP:0001993)3.03335778
15Obstructive sleep apnea (HP:0002870)2.99768937
16Late onset (HP:0003584)2.92849666
17Increased connective tissue (HP:0009025)2.92800474
18Type 1 muscle fiber predominance (HP:0003803)2.92482125
19Interstitial pulmonary disease (HP:0006530)2.90176184
20Nemaline bodies (HP:0003798)2.89628697
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.86844153
22Hypoglycemic coma (HP:0001325)2.80004125
23Axonal loss (HP:0003447)2.78742731
24Sudden death (HP:0001699)2.76773965
25Myokymia (HP:0002411)2.75891785
26Eczematoid dermatitis (HP:0000976)2.74768160
27Pheochromocytoma (HP:0002666)2.71735352
28Ketosis (HP:0001946)2.70867148
29Deep venous thrombosis (HP:0002625)2.67558673
30Hyperlipoproteinemia (HP:0010980)2.61199051
31Cellulitis (HP:0100658)2.59185182
32Exercise-induced myalgia (HP:0003738)2.57816183
33Ulnar bowing (HP:0003031)2.57699782
34Abnormality of the fingertips (HP:0001211)2.54982867
35Muscle fiber splitting (HP:0003555)2.54447354
36Dysmetric saccades (HP:0000641)2.52133054
37Asymmetric septal hypertrophy (HP:0001670)2.51274015
38Myoglobinuria (HP:0002913)2.50001180
39Intrahepatic cholestasis (HP:0001406)2.46499027
40Insomnia (HP:0100785)2.45734892
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.44140543
42Complement deficiency (HP:0004431)2.42228922
43Gout (HP:0001997)2.42222509
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.41549418
45Achilles tendon contracture (HP:0001771)2.41030227
46Distal lower limb amyotrophy (HP:0008944)2.40662511
47Cerebral hemorrhage (HP:0001342)2.39424754
48Action tremor (HP:0002345)2.38685275
49Progressive muscle weakness (HP:0003323)2.37985203
50Ankle clonus (HP:0011448)2.37638764
51Back pain (HP:0003418)2.35394862
52Neuroendocrine neoplasm (HP:0100634)2.31953976
53Rapidly progressive (HP:0003678)2.31739856
54Rhabdomyolysis (HP:0003201)2.31049720
55Turricephaly (HP:0000262)2.30849777
56Dysostosis multiplex (HP:0000943)2.27398620
57Aplasia involving bones of the upper limbs (HP:0009823)2.27303791
58Aplasia of the phalanges of the hand (HP:0009802)2.27303791
59Aplasia involving bones of the extremities (HP:0009825)2.27303791
60Polycythemia (HP:0001901)2.27033925
61Polygenic inheritance (HP:0010982)2.26765526
62Loss of speech (HP:0002371)2.26254716
63Hyperammonemia (HP:0001987)2.24912838
64Difficulty running (HP:0009046)2.24243772
65Insidious onset (HP:0003587)2.23937307
66Termporal pattern (HP:0011008)2.23937307
67Broad metatarsal (HP:0001783)2.23933158
68Amyloidosis (HP:0011034)2.21312024
69Exercise-induced muscle cramps (HP:0003710)2.20361735
70Respiratory distress (HP:0002098)2.20163513
71Foot dorsiflexor weakness (HP:0009027)2.19595485
72Long palpebral fissure (HP:0000637)2.17374980
73Recurrent abscess formation (HP:0002722)2.16450602
74Hyperinsulinemic hypoglycemia (HP:0000825)2.15381461
75Abnormality of fatty-acid metabolism (HP:0004359)2.13774393
76Increased cerebral lipofuscin (HP:0011813)2.13745416
77Bowel incontinence (HP:0002607)2.13247820
78Recurrent bacterial skin infections (HP:0005406)2.13173053
79Onion bulb formation (HP:0003383)2.12110328
80Tachypnea (HP:0002789)2.11915824
81Metaphyseal cupping (HP:0003021)2.11784039
82Lower limb amyotrophy (HP:0007210)2.10933606
83Large for gestational age (HP:0001520)2.10816090
84Abnormal gallbladder morphology (HP:0012437)2.10575193
85Segmental peripheral demyelination/remyelination (HP:0003481)2.09927578
86Bulbar palsy (HP:0001283)2.09017394
87Colitis (HP:0002583)2.08831612
88Gastrointestinal stroma tumor (HP:0100723)2.07979183
89Ventricular tachycardia (HP:0004756)2.06324120
90Abnormality of the salivary glands (HP:0010286)2.05771210
91Syncope (HP:0001279)2.05687990
92Ventricular fibrillation (HP:0001663)2.05009336
93Abnormality of glycine metabolism (HP:0010895)2.04291872
94Abnormality of serine family amino acid metabolism (HP:0010894)2.04291872
95Hypercortisolism (HP:0001578)2.03197620
96Ragged-red muscle fibers (HP:0003200)2.03045948
97Round ear (HP:0100830)2.02399620
98Abnormal gallbladder physiology (HP:0012438)2.01846907
99Cholecystitis (HP:0001082)2.01846907
100Right ventricular cardiomyopathy (HP:0011663)2.01439278
101Mesangial abnormality (HP:0001966)2.00507473
102Abnormality of the foot musculature (HP:0001436)1.99950921
103Diaphragmatic weakness (HP:0009113)1.99325516
104Bronchomalacia (HP:0002780)1.98146616
105Shallow orbits (HP:0000586)1.97692705
106Thin ribs (HP:0000883)1.97647467
107Cholelithiasis (HP:0001081)1.96041233
108Progressive neurologic deterioration (HP:0002344)1.95759822
109Abnormal large intestine physiology (HP:0012700)1.95529021
110EMG: myopathic abnormalities (HP:0003458)1.95516336
111Easy fatigability (HP:0003388)1.95411216
112Muscle stiffness (HP:0003552)1.94992490
113Hypoglycemic seizures (HP:0002173)1.94752328
114Atrioventricular block (HP:0001678)1.90220517
115Rigidity (HP:0002063)1.89918782
116Disproportionate tall stature (HP:0001519)1.88949912
117Intention tremor (HP:0002080)1.88516455
118Nasal polyposis (HP:0100582)1.88407957
119Myotonia (HP:0002486)1.88285403
120Persistence of primary teeth (HP:0006335)1.88103619
121Prolonged QT interval (HP:0001657)1.87508464
122Increased neuronal autofluorescent lipopigment (HP:0002074)1.87428395
123Bundle branch block (HP:0011710)1.86929820
124Progressive external ophthalmoplegia (HP:0000590)1.85869089
125Hypoalphalipoproteinemia (HP:0003233)1.85845213
126Sensorimotor neuropathy (HP:0007141)1.85786016
127Clumsiness (HP:0002312)1.85731279
128Increased variability in muscle fiber diameter (HP:0003557)1.84760545
129Broad distal phalanx of finger (HP:0009836)1.83413302
130Annular pancreas (HP:0001734)1.83205674
131Heart block (HP:0012722)1.82857745
132Calf muscle hypertrophy (HP:0008981)1.81981601
133Decreased motor nerve conduction velocity (HP:0003431)1.81195895
134Palpitations (HP:0001962)1.81180535
135Overriding aorta (HP:0002623)1.80406960
136Broad face (HP:0000283)1.80212087
137Peripheral hypomyelination (HP:0007182)1.79686353
138Stridor (HP:0010307)1.77425250
139Depression (HP:0000716)1.76227880
140Skin nodule (HP:0200036)1.76221838
141Subaortic stenosis (HP:0001682)1.75962804
142Abnormality of the left ventricular outflow tract (HP:0011103)1.75962804
143Hammertoe (HP:0001765)1.75673390
144Urinary glycosaminoglycan excretion (HP:0003541)1.75649906
145Mucopolysacchariduria (HP:0008155)1.75649906
146Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.74385396
147Systemic lupus erythematosus (HP:0002725)1.72809682
148Hypertriglyceridemia (HP:0002155)1.72475411
149Slow saccadic eye movements (HP:0000514)1.71933069
150Abnormality of complement system (HP:0005339)1.71751959
151Abnormal atrioventricular conduction (HP:0005150)1.71736891
152Hemorrhage of the eye (HP:0011885)1.71434425
153Abnormality of the Achilles tendon (HP:0005109)1.70876901
154Retinal atrophy (HP:0001105)1.70788162
155Germ cell neoplasia (HP:0100728)1.70550367
156Syringomyelia (HP:0003396)1.70104087
157Spinal cord lesions (HP:0100561)1.70104087
158Gastrointestinal inflammation (HP:0004386)1.67103570
159Abnormality of the calcaneus (HP:0008364)1.66783766
160Arnold-Chiari malformation (HP:0002308)1.65648708
161Increased IgE level (HP:0003212)1.65596953
162Truncus arteriosus (HP:0001660)1.65513828
163Chronic obstructive pulmonary disease (HP:0006510)1.64354233
164Obstructive lung disease (HP:0006536)1.64354233
165Hyperparathyroidism (HP:0000843)1.61933977
166Reticulocytosis (HP:0001923)1.61723331
167Vertebral compression fractures (HP:0002953)1.61690965
168Ulnar deviation of the wrist (HP:0003049)1.61250916
169Abnormality of macrophages (HP:0004311)1.61226269
170Hypertensive crisis (HP:0100735)1.60273920
171Calcaneovalgus deformity (HP:0001848)1.60261381
172Abnormality of the thoracic spine (HP:0100711)1.59292601
173Hypercalcemia (HP:0003072)1.59158659
174Recurrent gram-negative bacterial infections (HP:0005420)1.59152245
175Pointed chin (HP:0000307)1.59125491
176Cerebral aneurysm (HP:0004944)1.58486953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.50304898
2SMG14.13295708
3PRPF4B4.02490330
4EEF2K3.52193136
5TRIB33.34736057
6PHKG13.03995122
7PHKG23.03995122
8EPHB12.92807757
9RIPK42.28608778
10NTRK12.20993803
11MAP3K102.14914283
12BCKDK2.08970819
13CDK122.04647533
14ERN12.04430817
15TTN1.99142993
16KSR21.97409598
17SIK11.90674804
18MAP2K31.90476934
19LIMK11.83306060
20MAPK151.81890412
21MAP3K131.77306307
22RIPK11.75968879
23FGFR21.68263489
24PRKD31.60104890
25MAP3K21.50852828
26WNK41.47986162
27LRRK21.40469682
28STK391.40095484
29MAPKAPK51.38480322
30MAP4K11.36685598
31MAP3K91.34793239
32PKN21.31538862
33DMPK1.31359582
34EPHA41.27693273
35IRAK31.25753753
36PRKD11.22843977
37SGK2231.21776408
38SGK4941.21776408
39DAPK21.21456562
40PAK31.20502339
41MET1.16215258
42TESK21.15513026
43MAP2K21.15482669
44UHMK11.14796267
45TAOK21.14357491
46IRAK41.13942630
47LATS21.13907612
48ILK1.10211021
49MAP3K11.07169799
50PTK61.01799859
51MYLK1.00737501
52MTOR1.00587068
53PINK10.99760123
54ROCK20.99541360
55CAMK1G0.98190511
56DAPK30.93964407
57PAK60.93905704
58PKN10.92272468
59PTK20.91608018
60CAMK2D0.90995979
61RET0.89794567
62FER0.87615333
63PDPK10.87375487
64TNK20.86700776
65CAMK2G0.86432095
66WNK10.86152201
67BRAF0.84383082
68TESK10.84027100
69IRAK20.83932707
70PRKD20.83470709
71RPS6KA20.82271427
72RPS6KC10.79778236
73RPS6KL10.79778236
74MAP3K80.77776182
75TBK10.77709867
76CDK40.77428316
77MINK10.76408367
78MAPKAPK30.76327095
79TAOK30.76255275
80PRKCH0.76143637
81SCYL20.75928718
82ALK0.75788855
83ARAF0.75587981
84RPS6KB20.74498574
85CAMKK10.74332434
86PDGFRA0.73227045
87MAP2K10.72488198
88PRKG20.72474790
89MAPK70.70780281
90FGFR40.69323646
91ZAP700.68181858
92CDK60.68105306
93GRK60.66345206
94MAPK110.65482149
95TYK20.64920196
96WNK30.64853180
97MAP3K70.64568902
98TYRO30.64362923
99ROCK10.63535002
100CSK0.62909719
101CDK50.62750195
102CAMK2B0.62345153
103MAP3K140.60864285
104PIK3CG0.60685740
105RAF10.59823711
106MARK20.59053749
107ICK0.58808082
108SIK20.58243072
109NME20.58115483
110RPS6KA60.57941236
111HIPK20.57931513
112MOS0.57261218
113MAP3K110.56728131
114MAPK120.54739439
115OXSR10.54432496
116RPS6KA10.54282570
117MAP3K30.54075893
118BMX0.53828197
119FES0.52509592
120AKT20.51674912
121CAMKK20.51621346
122BLK0.51530341
123PDK30.50861201
124PDK40.50861201
125OBSCN0.50247934
126CDC42BPA0.49164214
127NTRK20.48873012
128TAOK10.48813393
129GRK50.47607473
130PIM10.47176719
131TIE10.47048515
132TGFBR20.46669321
133SGK30.46526395
134MAPK40.46284158
135STK110.45355732
136PDK10.44634018
137ERBB40.44389651
138CAMK1D0.43950798
139PRKACG0.43792818
140EPHA30.43277112
141DYRK1B0.43202467
142CAMK2A0.43108139
143YES10.41282019
144GSK3A0.40983351
145PRKCE0.40767163
146MST1R0.40678621
147MAPK100.39756812
148MUSK0.39567696
149JAK20.38272900
150MAP2K40.37656146
151HCK0.36651505
152PDGFRB0.36444582
153PIM20.36392821
154CDK70.35805950
155PAK40.35104068
156FGFR30.33970454

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.77105044
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.95350055
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.76157380
4Fatty acid degradation_Homo sapiens_hsa000712.57314393
5Fatty acid elongation_Homo sapiens_hsa000622.48462012
6Fatty acid metabolism_Homo sapiens_hsa012122.43699967
7Acute myeloid leukemia_Homo sapiens_hsa052212.16176059
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07564677
9Chronic myeloid leukemia_Homo sapiens_hsa052202.04136870
10Propanoate metabolism_Homo sapiens_hsa006402.00946738
11Fatty acid biosynthesis_Homo sapiens_hsa000611.95650797
12Steroid biosynthesis_Homo sapiens_hsa001001.95061094
13B cell receptor signaling pathway_Homo sapiens_hsa046621.93257736
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86114666
15Non-small cell lung cancer_Homo sapiens_hsa052231.80628858
16Central carbon metabolism in cancer_Homo sapiens_hsa052301.75271227
17Sulfur metabolism_Homo sapiens_hsa009201.73316942
18Butanoate metabolism_Homo sapiens_hsa006501.71207220
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70871372
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65091534
21Notch signaling pathway_Homo sapiens_hsa043301.64029649
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61715648
23Arginine biosynthesis_Homo sapiens_hsa002201.59876722
24VEGF signaling pathway_Homo sapiens_hsa043701.58305426
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.57836274
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56739963
27PPAR signaling pathway_Homo sapiens_hsa033201.54105712
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52103346
29Endometrial cancer_Homo sapiens_hsa052131.51966522
30Bladder cancer_Homo sapiens_hsa052191.50683103
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47561270
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44503972
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.43506053
34Thyroid cancer_Homo sapiens_hsa052161.42571157
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41156025
36Pyruvate metabolism_Homo sapiens_hsa006201.40435085
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35101737
38Pancreatic cancer_Homo sapiens_hsa052121.34172705
39Tryptophan metabolism_Homo sapiens_hsa003801.32442174
40Histidine metabolism_Homo sapiens_hsa003401.31857731
41Bile secretion_Homo sapiens_hsa049761.30584158
42Peroxisome_Homo sapiens_hsa041461.25905439
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25879283
44Fructose and mannose metabolism_Homo sapiens_hsa000511.25848436
45Osteoclast differentiation_Homo sapiens_hsa043801.25594244
46Carbon metabolism_Homo sapiens_hsa012001.23222472
47GnRH signaling pathway_Homo sapiens_hsa049121.21732421
48AMPK signaling pathway_Homo sapiens_hsa041521.20822273
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19306592
50Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16522969
51Glioma_Homo sapiens_hsa052141.15725610
52Lysosome_Homo sapiens_hsa041421.15553818
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15085660
54ErbB signaling pathway_Homo sapiens_hsa040121.14750839
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13814416
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11871380
57Long-term potentiation_Homo sapiens_hsa047201.11663215
58mTOR signaling pathway_Homo sapiens_hsa041501.07999813
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07007609
60Viral carcinogenesis_Homo sapiens_hsa052031.06888740
61Estrogen signaling pathway_Homo sapiens_hsa049151.04664977
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01598037
63Colorectal cancer_Homo sapiens_hsa052101.00995907
64Arginine and proline metabolism_Homo sapiens_hsa003300.98333365
65Complement and coagulation cascades_Homo sapiens_hsa046100.98113527
66ABC transporters_Homo sapiens_hsa020100.97418962
67Caffeine metabolism_Homo sapiens_hsa002320.97348096
68Prostate cancer_Homo sapiens_hsa052150.97243103
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.94489482
70Hepatitis C_Homo sapiens_hsa051600.93743626
71Leishmaniasis_Homo sapiens_hsa051400.92978420
72Systemic lupus erythematosus_Homo sapiens_hsa053220.92226831
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91838112
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91833070
75Biosynthesis of amino acids_Homo sapiens_hsa012300.91828681
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.91162978
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90070068
78Alcoholism_Homo sapiens_hsa050340.89633479
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88718029
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.88696588
81Hepatitis B_Homo sapiens_hsa051610.88481687
82beta-Alanine metabolism_Homo sapiens_hsa004100.87192433
83Apoptosis_Homo sapiens_hsa042100.87132438
84Starch and sucrose metabolism_Homo sapiens_hsa005000.86827457
85Choline metabolism in cancer_Homo sapiens_hsa052310.85662923
86Gastric acid secretion_Homo sapiens_hsa049710.84925652
87Prion diseases_Homo sapiens_hsa050200.81752535
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78874014
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78451223
90Insulin secretion_Homo sapiens_hsa049110.78423995
91Prolactin signaling pathway_Homo sapiens_hsa049170.78257382
92MAPK signaling pathway_Homo sapiens_hsa040100.78231158
93Inositol phosphate metabolism_Homo sapiens_hsa005620.77625854
94Fat digestion and absorption_Homo sapiens_hsa049750.76056698
95Cardiac muscle contraction_Homo sapiens_hsa042600.75686236
96Influenza A_Homo sapiens_hsa051640.74795867
97Galactose metabolism_Homo sapiens_hsa000520.72829382
98T cell receptor signaling pathway_Homo sapiens_hsa046600.72358064
99Tuberculosis_Homo sapiens_hsa051520.70771812
100Chemical carcinogenesis_Homo sapiens_hsa052040.70452076
101FoxO signaling pathway_Homo sapiens_hsa040680.70403162
102Dilated cardiomyopathy_Homo sapiens_hsa054140.69846782
103Staphylococcus aureus infection_Homo sapiens_hsa051500.69367266
104HIF-1 signaling pathway_Homo sapiens_hsa040660.68978479
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68471000
106GABAergic synapse_Homo sapiens_hsa047270.67640846
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66937942
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66617346
109HTLV-I infection_Homo sapiens_hsa051660.64811896
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64761304
111Type II diabetes mellitus_Homo sapiens_hsa049300.64721743
112MicroRNAs in cancer_Homo sapiens_hsa052060.64364604
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.63873853
114Glycerolipid metabolism_Homo sapiens_hsa005610.63310272
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61959789
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.60691151
117Toxoplasmosis_Homo sapiens_hsa051450.60674436
118Mineral absorption_Homo sapiens_hsa049780.60171885
119Sulfur relay system_Homo sapiens_hsa041220.59850239
120Proteoglycans in cancer_Homo sapiens_hsa052050.59166461
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59138574
122Lysine degradation_Homo sapiens_hsa003100.57415224
123Ether lipid metabolism_Homo sapiens_hsa005650.55261482
124Pancreatic secretion_Homo sapiens_hsa049720.54348559
125Pentose phosphate pathway_Homo sapiens_hsa000300.53248147
126Measles_Homo sapiens_hsa051620.52669772
127Folate biosynthesis_Homo sapiens_hsa007900.52410899
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52326160
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.51693733
130Amoebiasis_Homo sapiens_hsa051460.51419902
131Cocaine addiction_Homo sapiens_hsa050300.50642386
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50032945
133Salivary secretion_Homo sapiens_hsa049700.49795664
134Chemokine signaling pathway_Homo sapiens_hsa040620.49707863
135Melanogenesis_Homo sapiens_hsa049160.49383130
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48739759
137TNF signaling pathway_Homo sapiens_hsa046680.47704045
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.47555599
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47131556
140Oxytocin signaling pathway_Homo sapiens_hsa049210.47072696
141Insulin resistance_Homo sapiens_hsa049310.46856155
142Glutathione metabolism_Homo sapiens_hsa004800.46780412
143Phenylalanine metabolism_Homo sapiens_hsa003600.45684125
144Tyrosine metabolism_Homo sapiens_hsa003500.44329409
145Parkinsons disease_Homo sapiens_hsa050120.43431059
146Endocytosis_Homo sapiens_hsa041440.43138579
147Thyroid hormone synthesis_Homo sapiens_hsa049180.42449675
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41512078
149Alzheimers disease_Homo sapiens_hsa050100.41325565
150Olfactory transduction_Homo sapiens_hsa047400.40706823
151Circadian entrainment_Homo sapiens_hsa047130.40589606
152Insulin signaling pathway_Homo sapiens_hsa049100.39249041
153Synaptic vesicle cycle_Homo sapiens_hsa047210.38989876
154Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38329022
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.38158217
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38024210
157Vascular smooth muscle contraction_Homo sapiens_hsa042700.37324402
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.37303712
159Tight junction_Homo sapiens_hsa045300.35498000
160Oxidative phosphorylation_Homo sapiens_hsa001900.35419855
161Renin secretion_Homo sapiens_hsa049240.34204157
162Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34181083
163Sphingolipid metabolism_Homo sapiens_hsa006000.33211224
164Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32453363
165Gap junction_Homo sapiens_hsa045400.31351996
166Glutamatergic synapse_Homo sapiens_hsa047240.31307588
167Glucagon signaling pathway_Homo sapiens_hsa049220.31106043
168Dorso-ventral axis formation_Homo sapiens_hsa043200.30165908
169Renal cell carcinoma_Homo sapiens_hsa052110.30148153
170Other glycan degradation_Homo sapiens_hsa005110.29601721

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