MIEF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)4.98382585
2purine nucleobase biosynthetic process (GO:0009113)4.59180096
3peptidyl-arginine omega-N-methylation (GO:0035247)4.54626711
4intra-S DNA damage checkpoint (GO:0031573)4.52304088
5mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.47733437
6positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.47733437
7regulation of translational fidelity (GO:0006450)4.36938853
8nucleobase biosynthetic process (GO:0046112)4.24928639
9membrane disassembly (GO:0030397)4.08938162
10nuclear envelope disassembly (GO:0051081)4.08938162
11spliceosomal tri-snRNP complex assembly (GO:0000244)4.04634819
12positive regulation of protein sumoylation (GO:0033235)3.98728704
13microtubule depolymerization (GO:0007019)3.98267838
14negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.94094282
15ribosome assembly (GO:0042255)3.94006047
16cullin deneddylation (GO:0010388)3.92631507
17DNA ligation (GO:0006266)3.89084692
18peptidyl-arginine methylation (GO:0018216)3.87865073
19peptidyl-arginine N-methylation (GO:0035246)3.87865073
20nuclear pore complex assembly (GO:0051292)3.85970330
21nuclear pore organization (GO:0006999)3.83958187
22regulation of centriole replication (GO:0046599)3.82947433
23protein K6-linked ubiquitination (GO:0085020)3.77862668
24rRNA methylation (GO:0031167)3.74271772
25regulation of translational termination (GO:0006449)3.74235694
26protein complex localization (GO:0031503)3.73188066
27positive regulation of mitochondrial membrane permeability (GO:0035794)3.73050102
28histone H2A acetylation (GO:0043968)3.72642722
29IMP biosynthetic process (GO:0006188)3.72469428
30metaphase plate congression (GO:0051310)3.72181654
31regulation of RNA export from nucleus (GO:0046831)3.69589555
32single strand break repair (GO:0000012)3.67421360
33positive regulation of RNA splicing (GO:0033120)3.62846155
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.60348516
35mitotic sister chromatid segregation (GO:0000070)3.59771726
36ribosomal small subunit biogenesis (GO:0042274)3.59515744
37DNA replication checkpoint (GO:0000076)3.58905467
38regulation of mammary gland epithelial cell proliferation (GO:0033599)3.58712161
39rRNA modification (GO:0000154)3.57231195
40protein deneddylation (GO:0000338)3.56768029
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.56583863
42viral mRNA export from host cell nucleus (GO:0046784)3.56366403
43histone arginine methylation (GO:0034969)3.53554143
44establishment of chromosome localization (GO:0051303)3.51729297
45cellular protein complex localization (GO:0034629)3.51407774
46DNA conformation change (GO:0071103)3.50543413
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.50485386
48positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.50485386
49positive regulation of mitotic sister chromatid separation (GO:1901970)3.50485386
50kinetochore organization (GO:0051383)3.47678606
51DNA double-strand break processing (GO:0000729)3.41260931
52mitotic metaphase plate congression (GO:0007080)3.41163644
53somatic hypermutation of immunoglobulin genes (GO:0016446)3.38437233
54somatic diversification of immune receptors via somatic mutation (GO:0002566)3.38437233
55protein-DNA complex disassembly (GO:0032986)3.36498791
56nucleosome disassembly (GO:0006337)3.36498791
57negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.36298647
58negative regulation of phagocytosis (GO:0050765)3.36200970
59sister chromatid segregation (GO:0000819)3.36054963
60ribonucleoprotein complex biogenesis (GO:0022613)3.33908645
61negative regulation of DNA repair (GO:0045738)3.33770092
62tooth mineralization (GO:0034505)3.31867545
63proline biosynthetic process (GO:0006561)3.30739023
64protein localization to kinetochore (GO:0034501)3.29976978
65meiotic chromosome segregation (GO:0045132)3.29871201
66nuclear envelope organization (GO:0006998)3.28346140
67DNA replication initiation (GO:0006270)3.28035910
68positive regulation of chromosome segregation (GO:0051984)3.27603716
69folic acid-containing compound biosynthetic process (GO:0009396)3.24986851
70L-serine metabolic process (GO:0006563)3.23891010
71establishment of integrated proviral latency (GO:0075713)3.23510053
72negative regulation of mRNA processing (GO:0050686)3.23020247
73heterochromatin organization (GO:0070828)3.22394101
74DNA strand elongation involved in DNA replication (GO:0006271)3.19203371
75pre-miRNA processing (GO:0031054)3.18914109
76mitotic chromosome condensation (GO:0007076)3.18232173
77regulation of sister chromatid cohesion (GO:0007063)3.17234534
78formation of translation preinitiation complex (GO:0001731)3.13761001
79DNA duplex unwinding (GO:0032508)3.12657547
80regulation of mitotic spindle checkpoint (GO:1903504)3.12355098
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12355098
82rRNA transcription (GO:0009303)3.10970813
83DNA replication-dependent nucleosome organization (GO:0034723)3.10170553
84DNA replication-dependent nucleosome assembly (GO:0006335)3.10170553
85telomere maintenance via recombination (GO:0000722)3.09416357
86transcription from mitochondrial promoter (GO:0006390)3.09277669
87IMP metabolic process (GO:0046040)3.06962108
88negative regulation of mRNA metabolic process (GO:1903312)3.06123791
89maturation of SSU-rRNA (GO:0030490)3.05313500
90regulation of centrosome cycle (GO:0046605)3.05145723
91mitotic sister chromatid cohesion (GO:0007064)3.04158477
92regulation of nucleobase-containing compound transport (GO:0032239)3.04092852
93telomere maintenance via semi-conservative replication (GO:0032201)3.03778610
94mitotic recombination (GO:0006312)3.03534120
95DNA strand elongation (GO:0022616)3.03177074
96negative regulation of RNA splicing (GO:0033119)3.02413247
97negative regulation of dendrite morphogenesis (GO:0050774)3.01481433
98kinetochore assembly (GO:0051382)3.00575563
99transcription initiation from RNA polymerase I promoter (GO:0006361)3.00322702
100regulation of chromatin binding (GO:0035561)3.00169713
101DNA geometric change (GO:0032392)2.97948214
102spliceosomal snRNP assembly (GO:0000387)2.97494516
103poly(A)+ mRNA export from nucleus (GO:0016973)2.97382628
104RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.95851887
105snRNA processing (GO:0016180)2.95446490
106binding of sperm to zona pellucida (GO:0007339)2.94736334
107DNA unwinding involved in DNA replication (GO:0006268)2.94421822
108pore complex assembly (GO:0046931)2.94401624
109regulation of chromosome segregation (GO:0051983)2.94332944
110regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.94140238
111termination of RNA polymerase I transcription (GO:0006363)2.93901562
112negative regulation of histone methylation (GO:0031061)2.93686474
113mRNA transport (GO:0051028)2.91552223
114tRNA aminoacylation for protein translation (GO:0006418)2.87133254
115regulation of centrosome duplication (GO:0010824)2.87121477
116DNA synthesis involved in DNA repair (GO:0000731)2.86543093
117chromatin remodeling at centromere (GO:0031055)2.86342220
118positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.86289356
119RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85660492
120tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85660492
121CENP-A containing nucleosome assembly (GO:0034080)2.85417132
122amino acid activation (GO:0043038)2.83972597
123tRNA aminoacylation (GO:0043039)2.83972597
124transcription elongation from RNA polymerase I promoter (GO:0006362)2.82930676
125RNA stabilization (GO:0043489)2.82919554
126mRNA stabilization (GO:0048255)2.82919554
127regulation of NFAT protein import into nucleus (GO:0051532)2.81906155
128protein localization to chromosome, centromeric region (GO:0071459)2.81305944
129regulation of spindle organization (GO:0090224)2.81276231
130regulation of protein sumoylation (GO:0033233)2.78066404
131chromosome segregation (GO:0007059)2.77825975
132positive regulation of DNA-dependent DNA replication (GO:2000105)2.77822710
133Golgi transport vesicle coating (GO:0048200)2.77667443
134COPI coating of Golgi vesicle (GO:0048205)2.77667443
135DNA topological change (GO:0006265)2.76299516
136RNA localization (GO:0006403)2.76083245
137regulation of gene expression by genetic imprinting (GO:0006349)2.75404976
138resolution of meiotic recombination intermediates (GO:0000712)2.74739458
139recombinational repair (GO:0000725)2.74359965
140rRNA processing (GO:0006364)2.74327061
141replication fork processing (GO:0031297)2.73493590
142regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.72996381
143serine family amino acid biosynthetic process (GO:0009070)2.72916060
144mitotic nuclear envelope disassembly (GO:0007077)2.69955494
145protein export from nucleus (GO:0006611)2.69264158
146mismatch repair (GO:0006298)2.69146867
147transcription from RNA polymerase I promoter (GO:0006360)2.68104861
148regulation of translational elongation (GO:0006448)2.67740525
149nucleic acid transport (GO:0050657)2.67517915
150RNA transport (GO:0050658)2.67517915
151establishment of RNA localization (GO:0051236)2.67517915
152termination of RNA polymerase II transcription (GO:0006369)2.67120231
153ATP-dependent chromatin remodeling (GO:0043044)2.66922948
154snRNA metabolic process (GO:0016073)2.66262220
155double-strand break repair via homologous recombination (GO:0000724)2.65978893
156RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.64006857
157mRNA splicing, via spliceosome (GO:0000398)2.64006857
158regulation of histone H3-K9 methylation (GO:0051570)2.63591120
159DNA catabolic process, exonucleolytic (GO:0000738)2.63424984
160nucleotide-excision repair, DNA gap filling (GO:0006297)2.62534800
161ribosome biogenesis (GO:0042254)2.62142369
162maturation of 5.8S rRNA (GO:0000460)2.61274726
163positive regulation of protein import into nucleus, translocation (GO:0033160)2.59382591
164protein K11-linked deubiquitination (GO:0035871)2.56788065
165monoubiquitinated protein deubiquitination (GO:0035520)2.56096978
166regulation of DNA endoreduplication (GO:0032875)2.55738068
167maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55655697
168DNA packaging (GO:0006323)2.54602498
169attachment of spindle microtubules to kinetochore (GO:0008608)2.54534342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.51933351
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.57774171
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31019462
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25022190
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.07398530
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07072301
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.91161833
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.82485518
9MYC_22102868_ChIP-Seq_BL_Human2.81471500
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.80648782
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.80250166
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.71051903
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.40372776
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38934745
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38187496
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33860544
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.32439290
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30890155
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30820026
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22164404
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.21769631
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.18630668
23YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12853523
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.11118825
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09790434
26HOXB4_20404135_ChIP-ChIP_EML_Mouse2.06733835
27CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.06292757
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05948891
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03976104
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00932719
31E2F1_21310950_ChIP-Seq_MCF-7_Human2.00735920
32FOXP3_21729870_ChIP-Seq_TREG_Human1.97307227
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94259496
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93285860
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92396500
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90421374
37VDR_23849224_ChIP-Seq_CD4+_Human1.89036055
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.87756823
39ELK1_19687146_ChIP-ChIP_HELA_Human1.83777888
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82566325
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79783028
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78496764
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72825278
44VDR_21846776_ChIP-Seq_THP-1_Human1.63754118
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.62611316
46CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.62338365
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61468983
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61092036
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60939873
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59292076
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.59019116
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58831066
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.54422253
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54322048
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51847386
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.50767035
57GABP_19822575_ChIP-Seq_HepG2_Human1.48114962
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47861231
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43968494
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43416690
61DCP1A_22483619_ChIP-Seq_HELA_Human1.43192296
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43108507
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42384074
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41868138
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40513774
66AR_21909140_ChIP-Seq_LNCAP_Human1.39757574
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38984689
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.37960964
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37894027
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33213842
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.32241961
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30253582
73ZNF263_19887448_ChIP-Seq_K562_Human1.25831327
74KDM5A_27292631_Chip-Seq_BREAST_Human1.24874381
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24416623
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23937986
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21640018
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20044827
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19965168
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19553816
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16799656
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.15369241
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14836123
84XRN2_22483619_ChIP-Seq_HELA_Human1.14442929
85LXR_22292898_ChIP-Seq_THP-1_Human1.11803289
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11601163
87CIITA_25753668_ChIP-Seq_RAJI_Human1.11513377
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10345872
89CHD1_26751641_Chip-Seq_LNCaP_Human1.09519973
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.08814085
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05111361
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02999152
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01811723
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01279210
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01158971
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01070421
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00362124
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00159694
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99726911
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.99693501
101STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99534120
102GATA4_21415370_ChIP-Seq_HL-1_Mouse0.99226516
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98600364
104TTF2_22483619_ChIP-Seq_HELA_Human0.97832607
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97820391
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97234572
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97196303
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95748337
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.95737830
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93534983
111BP1_19119308_ChIP-ChIP_Hs578T_Human0.93467256
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93118029
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92514796
114TFEB_21752829_ChIP-Seq_HELA_Human0.91729680
115TET1_21451524_ChIP-Seq_MESCs_Mouse0.91447091
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90302473
117RACK7_27058665_Chip-Seq_MCF-7_Human0.88985905
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88798278
119NANOG_16153702_ChIP-ChIP_HESCs_Human0.88393720
120SALL4_22934838_ChIP-ChIP_CD34+_Human0.87720127
121FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.86495761
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86076865
123ATF3_27146783_Chip-Seq_COLON_Human0.84914303
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83639274
125CLOCK_20551151_ChIP-Seq_293T_Human0.83248237
126SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82993774
127EWS_26573619_Chip-Seq_HEK293_Human0.82719719
128NCOR1_26117541_ChIP-Seq_K562_Human0.82705184
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82651002
130TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82411690
131MYC_18940864_ChIP-ChIP_HL60_Human0.81805762
132ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80261350
133NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78840710
134POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76469150
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74683702
136POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73797198
137CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73201338

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.42561218
2MP0008057_abnormal_DNA_replication3.53175508
3MP0008877_abnormal_DNA_methylation3.23781114
4MP0003077_abnormal_cell_cycle3.22092358
5MP0008058_abnormal_DNA_repair3.18866664
6MP0003111_abnormal_nucleus_morphology3.00571771
7MP0005084_abnormal_gallbladder_morpholo2.80544705
8MP0008961_abnormal_basal_metabolism2.77017905
9MP0008007_abnormal_cellular_replicative2.61739193
10MP0004957_abnormal_blastocyst_morpholog2.59249050
11MP0005451_abnormal_body_composition2.54355659
12MP0006292_abnormal_olfactory_placode2.30780746
13MP0003693_abnormal_embryo_hatching2.26991156
14MP0003121_genomic_imprinting2.26897070
15MP0002877_abnormal_melanocyte_morpholog2.26577915
16MP0003806_abnormal_nucleotide_metabolis2.20382197
17MP0009697_abnormal_copulation2.19797127
18MP0010030_abnormal_orbit_morphology2.15542714
19MP0000015_abnormal_ear_pigmentation2.12605496
20MP0005623_abnormal_meninges_morphology2.11156323
21MP0004233_abnormal_muscle_weight2.09997087
22MP0005408_hypopigmentation2.06369537
23MP0010307_abnormal_tumor_latency2.06064247
24MP0002396_abnormal_hematopoietic_system2.04541022
25MP0003123_paternal_imprinting1.93670173
26MP0003787_abnormal_imprinting1.86470348
27MP0003950_abnormal_plasma_membrane1.75288491
28MP0001348_abnormal_lacrimal_gland1.74718183
29MP0003984_embryonic_growth_retardation1.73167207
30MP0005380_embryogenesis_phenotype1.71568274
31MP0001672_abnormal_embryogenesis/_devel1.71568274
32MP0002088_abnormal_embryonic_growth/wei1.71026456
33MP0004264_abnormal_extraembryonic_tissu1.70237192
34MP0002139_abnormal_hepatobiliary_system1.63541847
35MP0005076_abnormal_cell_differentiation1.59779202
36MP0004808_abnormal_hematopoietic_stem1.58964100
37MP0003718_maternal_effect1.58813687
38MP0003656_abnormal_erythrocyte_physiolo1.55345665
39MP0003705_abnormal_hypodermis_morpholog1.54678250
40MP0001764_abnormal_homeostasis1.53141418
41MP0001730_embryonic_growth_arrest1.50673364
42MP0004185_abnormal_adipocyte_glucose1.45690949
43MP0009672_abnormal_birth_weight1.43208988
44MP0005410_abnormal_fertilization1.39493943
45MP0002132_abnormal_respiratory_system1.37521431
46MP0003786_premature_aging1.36079009
47MP0005397_hematopoietic_system_phenotyp1.35823032
48MP0001545_abnormal_hematopoietic_system1.35823032
49MP0003943_abnormal_hepatobiliary_system1.35210526
50MP0001986_abnormal_taste_sensitivity1.35060955
51MP0000350_abnormal_cell_proliferation1.33995244
52MP0008932_abnormal_embryonic_tissue1.32973681
53MP0008260_abnormal_autophagy1.32720058
54MP0010352_gastrointestinal_tract_polyps1.31798836
55MP0002210_abnormal_sex_determination1.31218174
56MP0001697_abnormal_embryo_size1.31216760
57MP0005360_urolithiasis1.28344059
58MP0002086_abnormal_extraembryonic_tissu1.24173069
59MP0004147_increased_porphyrin_level1.23471414
60MP0002160_abnormal_reproductive_system1.22927759
61MP0001661_extended_life_span1.22674899
62MP0006035_abnormal_mitochondrial_morpho1.21809008
63MP0002876_abnormal_thyroid_physiology1.21800010
64MP0001929_abnormal_gametogenesis1.21303028
65MP0002697_abnormal_eye_size1.17627290
66MP0002249_abnormal_larynx_morphology1.17002016
67MP0005085_abnormal_gallbladder_physiolo1.16423276
68MP0001119_abnormal_female_reproductive1.16374655
69MP0001346_abnormal_lacrimal_gland1.10992719
70MP0005083_abnormal_biliary_tract1.08974972
71MP0000313_abnormal_cell_death1.07835522
72MP0000358_abnormal_cell_content/1.06469075
73MP0003011_delayed_dark_adaptation1.06112792
74MP0000003_abnormal_adipose_tissue1.06003215
75MP0003890_abnormal_embryonic-extraembry1.05992206
76MP0003186_abnormal_redox_activity1.04319682
77MP0004197_abnormal_fetal_growth/weight/1.03479940
78MP0002080_prenatal_lethality1.03320624
79MP0000537_abnormal_urethra_morphology1.02908545
80MP0003183_abnormal_peptide_metabolism1.02344772
81MP0001186_pigmentation_phenotype1.02238361
82MP0001849_ear_inflammation1.02126676
83MP0005389_reproductive_system_phenotype1.02035329
84MP0000372_irregular_coat_pigmentation1.01904356
85MP0002075_abnormal_coat/hair_pigmentati1.01839874
86MP0005075_abnormal_melanosome_morpholog1.00144756
87MP0002019_abnormal_tumor_incidence0.99606339
88MP0000678_abnormal_parathyroid_gland0.99537766
89MP0002398_abnormal_bone_marrow0.98322204
90MP0000689_abnormal_spleen_morphology0.98238300
91MP0001915_intracranial_hemorrhage0.96868238
92MP0001919_abnormal_reproductive_system0.96636872
93MP0001270_distended_abdomen0.95946396
94MP0000516_abnormal_urinary_system0.95888584
95MP0005367_renal/urinary_system_phenotyp0.95888584
96MP0002938_white_spotting0.94348814
97MP0002092_abnormal_eye_morphology0.94298197
98MP0004782_abnormal_surfactant_physiolog0.93435494
99MP0005220_abnormal_exocrine_pancreas0.93114938
100MP0001145_abnormal_male_reproductive0.93072235
101MP0009053_abnormal_anal_canal0.92366956
102MP0003115_abnormal_respiratory_system0.91683229
103MP0002085_abnormal_embryonic_tissue0.91067383
104MP0005670_abnormal_white_adipose0.90592922
105MP0000598_abnormal_liver_morphology0.89998216
106MP0002653_abnormal_ependyma_morphology0.89033808
107MP0003698_abnormal_male_reproductive0.88099956
108MP0003122_maternal_imprinting0.87615102
109MP0005409_darkened_coat_color0.87266919
110MP0010234_abnormal_vibrissa_follicle0.87095476
111MP0005501_abnormal_skin_physiology0.86796902
112MP0003136_yellow_coat_color0.86494290
113MP0003861_abnormal_nervous_system0.86069626
114MP0000653_abnormal_sex_gland0.85483277
115MP0005666_abnormal_adipose_tissue0.85289458
116MP0005384_cellular_phenotype0.85019176
117MP0003329_amyloid_beta_deposits0.84748429
118MP0003315_abnormal_perineum_morphology0.83840226
119MP0006036_abnormal_mitochondrial_physio0.81670825
120MP0000490_abnormal_crypts_of0.80997650
121MP0003221_abnormal_cardiomyocyte_apopto0.80191407
122MP0005375_adipose_tissue_phenotype0.79233311
123MP0005621_abnormal_cell_physiology0.78267049
124MP0000858_altered_metastatic_potential0.77719250
125MP0003385_abnormal_body_wall0.77044121
126MP0002009_preneoplasia0.76855150
127MP0005365_abnormal_bile_salt0.76435200
128MP0000465_gastrointestinal_hemorrhage0.75746944
129MP0000703_abnormal_thymus_morphology0.74839243
130MP0005266_abnormal_metabolism0.74782541
131MP0001286_abnormal_eye_development0.74120819
132MP0000371_diluted_coat_color0.73787476
133MP0002111_abnormal_tail_morphology0.72737609
134MP0003942_abnormal_urinary_system0.71942554
135MP0009333_abnormal_splenocyte_physiolog0.71385812
136MP0003566_abnormal_cell_adhesion0.71269900
137MP0000609_abnormal_liver_physiology0.71125377
138MP0002098_abnormal_vibrissa_morphology0.70989386
139MP0005646_abnormal_pituitary_gland0.70279434
140MP0002722_abnormal_immune_system0.69968308
141MP0001529_abnormal_vocalization0.69425366
142MP0002161_abnormal_fertility/fecundity0.69069781
143MP0002429_abnormal_blood_cell0.67309578
144MP0002084_abnormal_developmental_patter0.67111127
145MP0003763_abnormal_thymus_physiology0.66699861
146MP0003959_abnormal_lean_body0.66205290
147MP0002095_abnormal_skin_pigmentation0.64960736
148MP0005257_abnormal_intraocular_pressure0.64332831
149MP0009115_abnormal_fat_cell0.63703534
150MP0002970_abnormal_white_adipose0.62885055

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.06355251
2Cutaneous melanoma (HP:0012056)4.06011636
3Abnormal hair whorl (HP:0010721)3.47008112
4Chromsome breakage (HP:0040012)3.45713769
5Microvesicular hepatic steatosis (HP:0001414)3.44460186
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34778284
7Thrombocytosis (HP:0001894)3.31812572
8Progressive muscle weakness (HP:0003323)3.29410580
9Multiple enchondromatosis (HP:0005701)3.28752909
10Proximal placement of thumb (HP:0009623)3.24823417
11Hyperacusis (HP:0010780)3.11982058
12Asymmetry of the thorax (HP:0001555)3.09583269
13Increased nuchal translucency (HP:0010880)3.08893788
14Abnormal lung lobation (HP:0002101)3.08777727
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.08115580
16Ragged-red muscle fibers (HP:0003200)3.02819795
17Deep philtrum (HP:0002002)2.95585483
18Abnormality of chromosome stability (HP:0003220)2.95367438
19Abnormality of the ileum (HP:0001549)2.90337137
20Cortical dysplasia (HP:0002539)2.89391265
21Myelodysplasia (HP:0002863)2.79293049
22Meckel diverticulum (HP:0002245)2.78574980
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.77670405
24Septate vagina (HP:0001153)2.77660601
25Nephroblastoma (Wilms tumor) (HP:0002667)2.74532975
26Upper limb muscle weakness (HP:0003484)2.72654603
27Abnormality of the preputium (HP:0100587)2.70924792
28Abnormality of pyrimidine metabolism (HP:0004353)2.69388666
29Amaurosis fugax (HP:0100576)2.64453947
30Embryonal renal neoplasm (HP:0011794)2.63358163
31Termporal pattern (HP:0011008)2.63090985
32Insidious onset (HP:0003587)2.63090985
33Agnosia (HP:0010524)2.60535089
34Neonatal hypoglycemia (HP:0001998)2.58220234
35Insomnia (HP:0100785)2.56461000
36Spinal cord lesions (HP:0100561)2.48734735
37Syringomyelia (HP:0003396)2.48734735
38Long palpebral fissure (HP:0000637)2.48329200
39Abnormality of the labia minora (HP:0012880)2.43689614
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.38629977
41Progressive external ophthalmoplegia (HP:0000590)2.38056777
42Bone marrow hypocellularity (HP:0005528)2.34597739
43Intestinal atresia (HP:0011100)2.32393721
44Medulloblastoma (HP:0002885)2.30871732
45Trismus (HP:0000211)2.29272197
46Abnormality of the carotid arteries (HP:0005344)2.28253971
47Squamous cell carcinoma (HP:0002860)2.26050853
48Tongue fasciculations (HP:0001308)2.25169568
49Abnormality of lateral ventricle (HP:0030047)2.24525424
50Anal stenosis (HP:0002025)2.23854636
51Sparse lateral eyebrow (HP:0005338)2.22037695
52Renal duplication (HP:0000075)2.21042259
53Ectopic kidney (HP:0000086)2.19728699
54Neoplasm of the adrenal gland (HP:0100631)2.19628607
55Breast hypoplasia (HP:0003187)2.18640582
56Upper motor neuron abnormality (HP:0002127)2.17809917
57Sloping forehead (HP:0000340)2.17459005
58Impulsivity (HP:0100710)2.16408985
59Impaired proprioception (HP:0010831)2.14903518
60Abnormality of alanine metabolism (HP:0010916)2.13951052
61Hyperalaninemia (HP:0003348)2.13951052
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13951052
63High anterior hairline (HP:0009890)2.11889255
64Protruding tongue (HP:0010808)2.11299556
65Abnormal number of incisors (HP:0011064)2.10578413
66Abnormality of the fetal cardiovascular system (HP:0010948)2.09274390
67Abnormal umbilical cord blood vessels (HP:0011403)2.09274390
68Single umbilical artery (HP:0001195)2.09274390
69Obsessive-compulsive behavior (HP:0000722)2.09200774
70Glossoptosis (HP:0000162)2.07222073
71Personality changes (HP:0000751)2.05579129
72Hypoparathyroidism (HP:0000829)2.05022114
73Dysmetric saccades (HP:0000641)2.04984681
74Truncus arteriosus (HP:0001660)2.04879668
75Small intestinal stenosis (HP:0012848)2.02882097
76Duodenal stenosis (HP:0100867)2.02882097
77Abnormal gallbladder physiology (HP:0012438)2.02572231
78Cholecystitis (HP:0001082)2.02572231
79Missing ribs (HP:0000921)2.02036552
80Clubbing of toes (HP:0100760)2.01030053
81Ankyloglossia (HP:0010296)2.00735282
82Abnormality of the umbilical cord (HP:0010881)2.00673699
83Gonadotropin excess (HP:0000837)2.00477064
84Hypobetalipoproteinemia (HP:0003563)1.99517182
85Type 2 muscle fiber atrophy (HP:0003554)1.98819498
86Long eyelashes (HP:0000527)1.98712658
87Deviation of the thumb (HP:0009603)1.97482181
88Overriding aorta (HP:0002623)1.97224924
89Broad distal phalanx of finger (HP:0009836)1.97138129
90Enlarged kidneys (HP:0000105)1.96580907
91Spontaneous abortion (HP:0005268)1.96440418
92Renovascular hypertension (HP:0100817)1.96122985
93Patellar aplasia (HP:0006443)1.94353193
94Deep palmar crease (HP:0006191)1.93724465
95Curly hair (HP:0002212)1.92774220
96Neoplasm of the adrenal cortex (HP:0100641)1.92511653
97Abnormality of the duodenum (HP:0002246)1.92354310
98Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92218429
99Long foot (HP:0001833)1.92165923
100Large earlobe (HP:0009748)1.92004028
101Osteomalacia (HP:0002749)1.90258401
102Self-mutilation (HP:0000742)1.90014861
103Thyroid carcinoma (HP:0002890)1.89760605
104Acute myeloid leukemia (HP:0004808)1.89209206
105Intestinal fistula (HP:0100819)1.88825044
106Unilateral renal agenesis (HP:0000122)1.86971535
107Renal cortical cysts (HP:0000803)1.86931312
108Spastic diplegia (HP:0001264)1.85253133
109Long clavicles (HP:0000890)1.85196261
110Preauricular skin tag (HP:0000384)1.84856925
111Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84821078
112Short 4th metacarpal (HP:0010044)1.84821078
113Muscle fibrillation (HP:0010546)1.84247509
114Patellar dislocation (HP:0002999)1.83806429
115Trigonocephaly (HP:0000243)1.83771370
116Meningioma (HP:0002858)1.82707700
117Rhabdomyosarcoma (HP:0002859)1.82287548
118Arterial thrombosis (HP:0004420)1.82066836
119Fatigue (HP:0012378)1.81934481
120Abnormality of the distal phalanx of the thumb (HP:0009617)1.81755966
12111 pairs of ribs (HP:0000878)1.81493347
122Abnormality of the anterior horn cell (HP:0006802)1.81453474
123Degeneration of anterior horn cells (HP:0002398)1.81453474
124Urethral obstruction (HP:0000796)1.81412669
125Choanal atresia (HP:0000453)1.80277021
126Complete atrioventricular canal defect (HP:0001674)1.79405604
127Overlapping toe (HP:0001845)1.79013059
128Atresia of the external auditory canal (HP:0000413)1.78115077
129Elfin facies (HP:0004428)1.76980622
130Generalized hypotonia (HP:0001290)1.76904541
131Hypothermia (HP:0002045)1.76525006
132Premature ovarian failure (HP:0008209)1.76337195
133Skin tags (HP:0010609)1.74380063
134Reticulocytosis (HP:0001923)1.73289906
135Abnormality of incisor morphology (HP:0011063)1.72724205
136Progressive sensorineural hearing impairment (HP:0000408)1.72021216
137Pointed chin (HP:0000307)1.71057658
138Cystic hygroma (HP:0000476)1.70662761
139Anomalous pulmonary venous return (HP:0010772)1.70449614
140Progressive hearing impairment (HP:0001730)1.70205462
141Delayed closure of the anterior fontanelle (HP:0001476)1.69607783
142Papillary thyroid carcinoma (HP:0002895)1.69535571
143Rough bone trabeculation (HP:0100670)1.69203523
144Supernumerary spleens (HP:0009799)1.69085793
145Spastic paraparesis (HP:0002313)1.67465983
146Abnormality of the fingertips (HP:0001211)1.66996858
147Muscle fiber atrophy (HP:0100295)1.66555155
148Poikiloderma (HP:0001029)1.65918433
149Secondary amenorrhea (HP:0000869)1.65581913
150Aplasia/Hypoplasia of the patella (HP:0006498)1.65469893
151Hepatitis (HP:0012115)1.65448197
152Selective tooth agenesis (HP:0001592)1.64720039
153Volvulus (HP:0002580)1.64283070
154Depressed nasal tip (HP:0000437)1.63863625
155Hypoplastic left heart (HP:0004383)1.63856559
156Hammertoe (HP:0001765)1.62899364
157Radioulnar synostosis (HP:0002974)1.62835664
158Achilles tendon contracture (HP:0001771)1.62683485
159Submucous cleft hard palate (HP:0000176)1.62349259
160Reduced antithrombin III activity (HP:0001976)1.62076986
161Congenital malformation of the right heart (HP:0011723)1.62025886
162Double outlet right ventricle (HP:0001719)1.62025886
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.61980790
164Absent epiphyses (HP:0010577)1.61980790
165Hypergonadotropic hypogonadism (HP:0000815)1.61954788
166Disproportionate tall stature (HP:0001519)1.61619758
167Hypochromic microcytic anemia (HP:0004840)1.61422792
168Abnormal large intestine physiology (HP:0012700)1.60572257
169Cafe-au-lait spot (HP:0000957)1.60320935
170Freckling (HP:0001480)1.60018511
171Abnormality of the phalanges of the hallux (HP:0010057)1.59688011
172Abnormalities of placenta or umbilical cord (HP:0001194)1.59638060
173Abnormality of reticulocytes (HP:0004312)1.59599533
174Increased serum pyruvate (HP:0003542)1.58864966
175Abnormality of glycolysis (HP:0004366)1.58864966
176Abnormality of B cell number (HP:0010975)1.58127665
177B lymphocytopenia (HP:0010976)1.58127665
178Diastasis recti (HP:0001540)1.57889952
179Abnormality of oral frenula (HP:0000190)1.57700027
180Type I transferrin isoform profile (HP:0003642)1.56785188
181Abnormal connection of the cardiac segments (HP:0011545)1.56365438
182Abnormal ventriculo-arterial connection (HP:0011563)1.56365438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.48799152
2PASK3.44661087
3PRPF4B3.38429435
4CASK3.33280322
5TSSK63.28203447
6VRK13.26423991
7AKT32.70950286
8BRSK22.56243681
9PLK32.53764728
10SIK32.47708562
11STK38L2.40410757
12ICK2.37753561
13NME22.32214778
14BUB12.17235884
15FRK2.16809037
16ZAK2.16359294
17WEE12.13158474
18YES12.06229358
19NTRK22.05516168
20TRIB32.03067436
21BRD42.02620404
22CDC72.00678165
23PDK31.98772759
24PDK41.98772759
25SRPK11.96898940
26MKNK11.92473667
27IRAK31.80195344
28MKNK21.78417237
29TRPM71.71777972
30SGK21.66458745
31CDK81.56504991
32MAP3K141.50685839
33PBK1.46610809
34SCYL21.35019290
35CAMK1D1.33267543
36CCNB11.33166517
37PRKD31.32341401
38MAP3K91.29755551
39MAP3K81.29712576
40ERBB31.26746210
41CAMK1G1.26467033
42LATS21.25214572
43BRSK11.23135718
44PLK11.20431520
45NEK11.16906409
46ATR1.15058357
47STK241.12680055
48TXK1.10919380
49KSR21.10731046
50PIM21.09810144
51TTK1.06905413
52FGFR21.06567240
53SIK21.05558604
54CDK61.05004522
55CHEK21.03029401
56STK41.02973676
57TAOK31.01171943
58TLK11.00885365
59VRK21.00191252
60PLK40.99754597
61MTOR0.99690284
62PDK20.97852302
63NEK90.96899824
64BCR0.96151927
65MAPK130.94571179
66PIM10.93575309
67PLK20.93023409
68ALK0.91939828
69RPS6KB10.91475518
70RPS6KB20.91257733
71SGK30.89981253
72RPS6KA60.89524037
73RPS6KC10.87429174
74RPS6KL10.87429174
75TAOK20.85777582
76AURKA0.85315242
77STK30.84643649
78EIF2AK10.84252870
79CDK70.82938990
80AURKB0.82198579
81AKT20.81141093
82BRAF0.80436951
83MAPK110.77922936
84STK160.77853484
85ATM0.77441865
86FGFR30.76851783
87IRAK40.72911244
88TESK10.71521542
89EIF2AK20.71337697
90DDR20.70697700
91CHEK10.70376655
92CLK10.68246614
93CDK40.67752154
94MST1R0.66351057
95FGFR40.65930003
96MAP3K120.64602019
97MAP4K10.64390417
98ERBB40.63939462
99LATS10.63162824
100CDK120.63150607
101RAF10.62245247
102PNCK0.61408608
103CDK90.60521264
104SIK10.60165233
105MYLK0.59709659
106RPS6KA20.59639944
107FLT30.58612474
108ARAF0.58428782
109TRIM280.55516316
110NEK20.55435978
111CHUK0.54888349
112PKN20.54734717
113ACVR1B0.54100630
114TNIK0.52971335
115SGK4940.52603185
116SGK2230.52603185
117IRAK20.52533572
118PIK3CA0.52426765
119ADRBK20.52039452
120TESK20.49899912
121CDK11A0.49795150
122PDGFRA0.49331165
123TEC0.47615077
124MAP3K100.47036792
125PDPK10.45462927
126CSNK2A10.45383717
127BMPR1B0.44805650
128GRK70.44621204
129CDK20.43722904
130MAP2K30.43638677
131EPHA20.43614648
132ZAP700.43208061
133STK100.43059717
134CDK140.42445966
135TAF10.42169678
136MAPK140.41957579
137GSK3B0.41739542
138RPS6KA40.40757488
139CDK150.40527895
140RIPK40.39621217
141CDK180.39400723
142CDK10.38834041
143EIF2AK30.38569448
144DAPK10.38221743
145EEF2K0.37915407
146KSR10.37875546
147MAP2K70.37561540
148MARK30.34278617
149MAPK30.34005518
150BTK0.32187291
151PAK40.31699402
152BCKDK0.31308909
153CSNK2A20.31209068

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.50037987
2Mismatch repair_Homo sapiens_hsa034303.49051900
3Sulfur relay system_Homo sapiens_hsa041223.28264420
4Base excision repair_Homo sapiens_hsa034103.18927110
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01203663
6Homologous recombination_Homo sapiens_hsa034402.91492852
7One carbon pool by folate_Homo sapiens_hsa006702.82197671
8Basal transcription factors_Homo sapiens_hsa030222.64265873
9Non-homologous end-joining_Homo sapiens_hsa034502.52567861
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41656340
11RNA transport_Homo sapiens_hsa030132.38883357
12Nucleotide excision repair_Homo sapiens_hsa034202.36407596
13Cell cycle_Homo sapiens_hsa041102.27604953
14RNA degradation_Homo sapiens_hsa030182.10009809
15Spliceosome_Homo sapiens_hsa030402.02632067
16Fanconi anemia pathway_Homo sapiens_hsa034601.94310333
17Proteasome_Homo sapiens_hsa030501.92304577
18RNA polymerase_Homo sapiens_hsa030201.80152195
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73915882
20Pyrimidine metabolism_Homo sapiens_hsa002401.72538140
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68814357
22Selenocompound metabolism_Homo sapiens_hsa004501.56176720
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53952145
24Ribosome_Homo sapiens_hsa030101.48899015
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.44826048
26mRNA surveillance pathway_Homo sapiens_hsa030151.42327539
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.42274287
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40472435
29Biosynthesis of amino acids_Homo sapiens_hsa012301.35934115
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35493088
31Steroid biosynthesis_Homo sapiens_hsa001001.35043480
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34036176
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31860730
34Systemic lupus erythematosus_Homo sapiens_hsa053221.29894990
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29892563
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.25163500
37Protein export_Homo sapiens_hsa030601.24256459
38Bladder cancer_Homo sapiens_hsa052191.21289387
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19532100
40Chronic myeloid leukemia_Homo sapiens_hsa052201.18939697
41Fatty acid elongation_Homo sapiens_hsa000621.16524604
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15743714
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14734470
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12069910
45Vitamin B6 metabolism_Homo sapiens_hsa007501.08960713
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06781276
47Purine metabolism_Homo sapiens_hsa002301.04169407
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.03703676
49Pyruvate metabolism_Homo sapiens_hsa006200.99944603
50p53 signaling pathway_Homo sapiens_hsa041150.99275066
51Epstein-Barr virus infection_Homo sapiens_hsa051690.97571971
52Carbon metabolism_Homo sapiens_hsa012000.97445444
53Herpes simplex infection_Homo sapiens_hsa051680.93242060
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92606490
55Viral carcinogenesis_Homo sapiens_hsa052030.91998284
56Arginine biosynthesis_Homo sapiens_hsa002200.90316606
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89166054
58Vibrio cholerae infection_Homo sapiens_hsa051100.87360857
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84505567
60Oocyte meiosis_Homo sapiens_hsa041140.83992932
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83002162
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81959550
63Legionellosis_Homo sapiens_hsa051340.80040969
64Peroxisome_Homo sapiens_hsa041460.79409429
65Pancreatic cancer_Homo sapiens_hsa052120.78895497
66N-Glycan biosynthesis_Homo sapiens_hsa005100.77776655
67Prostate cancer_Homo sapiens_hsa052150.77180400
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75484910
69Fatty acid metabolism_Homo sapiens_hsa012120.73774332
70Measles_Homo sapiens_hsa051620.72797766
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72421206
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.71397541
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69984936
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69881638
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67070479
76Acute myeloid leukemia_Homo sapiens_hsa052210.66889549
77Fructose and mannose metabolism_Homo sapiens_hsa000510.63176398
78Galactose metabolism_Homo sapiens_hsa000520.62577005
79Colorectal cancer_Homo sapiens_hsa052100.61893795
80Folate biosynthesis_Homo sapiens_hsa007900.61458700
81Complement and coagulation cascades_Homo sapiens_hsa046100.58983724
82MicroRNAs in cancer_Homo sapiens_hsa052060.57290134
83Pentose phosphate pathway_Homo sapiens_hsa000300.55957090
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55120512
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54949193
86Propanoate metabolism_Homo sapiens_hsa006400.54418702
87Small cell lung cancer_Homo sapiens_hsa052220.54277697
88Fat digestion and absorption_Homo sapiens_hsa049750.53184064
89Apoptosis_Homo sapiens_hsa042100.52359044
90Prion diseases_Homo sapiens_hsa050200.52211938
91Fatty acid degradation_Homo sapiens_hsa000710.51562148
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51288518
93Insulin signaling pathway_Homo sapiens_hsa049100.50647833
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.50346306
95Lysine degradation_Homo sapiens_hsa003100.49946812
96Endometrial cancer_Homo sapiens_hsa052130.46515908
97AMPK signaling pathway_Homo sapiens_hsa041520.45908339
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.44999567
99Arginine and proline metabolism_Homo sapiens_hsa003300.44720700
100Renal cell carcinoma_Homo sapiens_hsa052110.43591917
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42657545
102Adherens junction_Homo sapiens_hsa045200.42478524
103Phenylalanine metabolism_Homo sapiens_hsa003600.41994380
104Renin-angiotensin system_Homo sapiens_hsa046140.41955161
105Tryptophan metabolism_Homo sapiens_hsa003800.41535918
106Allograft rejection_Homo sapiens_hsa053300.41266789
107Metabolic pathways_Homo sapiens_hsa011000.41106829
108Thyroid cancer_Homo sapiens_hsa052160.41017047
109Butanoate metabolism_Homo sapiens_hsa006500.40610756
110Hippo signaling pathway_Homo sapiens_hsa043900.40195104
111Influenza A_Homo sapiens_hsa051640.39974437
112Starch and sucrose metabolism_Homo sapiens_hsa005000.39965996
113Antigen processing and presentation_Homo sapiens_hsa046120.38937686
114Glioma_Homo sapiens_hsa052140.38594902
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.37998801
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37759412
117Hepatitis B_Homo sapiens_hsa051610.36633875
118Staphylococcus aureus infection_Homo sapiens_hsa051500.35643711
119Sulfur metabolism_Homo sapiens_hsa009200.34372534
120beta-Alanine metabolism_Homo sapiens_hsa004100.33266941
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33172891
122Thyroid hormone synthesis_Homo sapiens_hsa049180.32779291
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32248445
124Arachidonic acid metabolism_Homo sapiens_hsa005900.32048887
125Retinol metabolism_Homo sapiens_hsa008300.31602290
126Estrogen signaling pathway_Homo sapiens_hsa049150.31522896
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.31154173
128HTLV-I infection_Homo sapiens_hsa051660.30020641
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30000477
130Tyrosine metabolism_Homo sapiens_hsa003500.29581883
131Hepatitis C_Homo sapiens_hsa051600.29077106
132Fatty acid biosynthesis_Homo sapiens_hsa000610.28703671
133ErbB signaling pathway_Homo sapiens_hsa040120.28616844
134Primary immunodeficiency_Homo sapiens_hsa053400.28291084
135Olfactory transduction_Homo sapiens_hsa047400.28062316
136Phagosome_Homo sapiens_hsa041450.26254535
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25727761
138Non-small cell lung cancer_Homo sapiens_hsa052230.25431430

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