MIEF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an outer mitochondrial membrane protein that functions in the regulation of mitochondrial morphology. It can directly recruit the fission mediator dynamin-related protein 1 (Drp1) to the mitochondrial surface. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)5.93165979
2muscle filament sliding (GO:0030049)5.93165979
3regulation of skeletal muscle contraction (GO:0014819)5.09344499
4behavioral response to nicotine (GO:0035095)4.73474144
5actin-mediated cell contraction (GO:0070252)4.71217347
6daunorubicin metabolic process (GO:0044597)4.32416954
7polyketide metabolic process (GO:0030638)4.32416954
8doxorubicin metabolic process (GO:0044598)4.32416954
9* positive regulation of mitochondrial fission (GO:0090141)4.30271323
10skeletal muscle contraction (GO:0003009)4.25629199
11oxidative phosphorylation (GO:0006119)4.10058557
12sarcomere organization (GO:0045214)3.94200705
13heart contraction (GO:0060047)3.85169476
14heart process (GO:0003015)3.85169476
15pyrimidine nucleobase catabolic process (GO:0006208)3.82274899
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.72840574
17skeletal muscle adaptation (GO:0043501)3.71050071
18epithelial cilium movement (GO:0003351)3.61653980
19tricarboxylic acid cycle (GO:0006099)3.59057163
20NAD biosynthetic process (GO:0009435)3.57286165
21cytochrome complex assembly (GO:0017004)3.54926919
22myofibril assembly (GO:0030239)3.51739769
23branched-chain amino acid catabolic process (GO:0009083)3.46340277
24regulation of relaxation of muscle (GO:1901077)3.38943297
25valine metabolic process (GO:0006573)3.36363600
26response to interferon-beta (GO:0035456)3.36032782
27protein polyglutamylation (GO:0018095)3.35869522
28* regulation of mitochondrial fission (GO:0090140)3.34799056
29aerobic respiration (GO:0009060)3.34409705
30sarcoplasmic reticulum calcium ion transport (GO:0070296)3.31961917
31carnitine shuttle (GO:0006853)3.28344521
32glyoxylate metabolic process (GO:0046487)3.25842414
33axoneme assembly (GO:0035082)3.25786679
34branched-chain amino acid metabolic process (GO:0009081)3.25379123
35nonmotile primary cilium assembly (GO:0035058)3.25039308
36preassembly of GPI anchor in ER membrane (GO:0016254)3.24137722
37response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.24111574
38respiratory chain complex IV assembly (GO:0008535)3.24023323
39cytidine deamination (GO:0009972)3.23993943
40cytidine metabolic process (GO:0046087)3.23993943
41cytidine catabolic process (GO:0006216)3.23993943
42quinone biosynthetic process (GO:1901663)3.19480982
43ubiquinone biosynthetic process (GO:0006744)3.19480982
44synaptic transmission, cholinergic (GO:0007271)3.19166641
45fatty acid transmembrane transport (GO:1902001)3.16787380
46regulation of cilium movement (GO:0003352)3.16372197
47tryptophan catabolic process (GO:0006569)3.16238606
48indole-containing compound catabolic process (GO:0042436)3.16238606
49indolalkylamine catabolic process (GO:0046218)3.16238606
50substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.16166504
51substrate-independent telencephalic tangential migration (GO:0021826)3.16166504
52NAD metabolic process (GO:0019674)3.14993110
53pyrimidine ribonucleoside catabolic process (GO:0046133)3.13964363
54negative regulation of telomere maintenance (GO:0032205)3.13586108
55protein complex biogenesis (GO:0070271)3.12367385
56actin filament-based movement (GO:0030048)3.11603793
57nicotinamide nucleotide biosynthetic process (GO:0019359)3.09668989
58pyridine nucleotide biosynthetic process (GO:0019363)3.09668989
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.08757309
60purine nucleotide salvage (GO:0032261)3.05960533
61cornea development in camera-type eye (GO:0061303)3.05313384
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05258690
63succinate metabolic process (GO:0006105)3.05050817
64oxaloacetate metabolic process (GO:0006107)3.04811461
65skeletal muscle tissue regeneration (GO:0043403)3.04441998
66regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.03960432
67glycosphingolipid biosynthetic process (GO:0006688)3.00364072
68neuronal action potential propagation (GO:0019227)2.99386074
69cilium movement (GO:0003341)2.98464126
70nucleobase catabolic process (GO:0046113)2.97860885
71fatty acid beta-oxidation (GO:0006635)2.97645864
72auditory receptor cell stereocilium organization (GO:0060088)2.97150768
73striated muscle contraction (GO:0006941)2.96721090
74respiratory electron transport chain (GO:0022904)2.96712787
75metallo-sulfur cluster assembly (GO:0031163)2.95782452
76iron-sulfur cluster assembly (GO:0016226)2.95782452
77cellular response to zinc ion (GO:0071294)2.93101880
78protein-cofactor linkage (GO:0018065)2.93046213
79neuronal action potential (GO:0019228)2.92379575
80mitochondrial respiratory chain complex assembly (GO:0033108)2.91779382
81positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.90952253
82NADH metabolic process (GO:0006734)2.90839461
83purine-containing compound salvage (GO:0043101)2.90777407
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.89904831
85membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89781169
86skeletal muscle fiber development (GO:0048741)2.88672143
87electron transport chain (GO:0022900)2.88456388
88kynurenine metabolic process (GO:0070189)2.88043824
892-oxoglutarate metabolic process (GO:0006103)2.87005135
90axonemal dynein complex assembly (GO:0070286)2.86718713
91aldehyde catabolic process (GO:0046185)2.85612053
92ubiquinone metabolic process (GO:0006743)2.85179404
93striated muscle atrophy (GO:0014891)2.84894303
94detection of light stimulus involved in visual perception (GO:0050908)2.84355214
95detection of light stimulus involved in sensory perception (GO:0050962)2.84355214
96negative regulation of viral genome replication (GO:0045071)2.80796523
97ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.79079306
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78711500
99mitochondrial respiratory chain complex I assembly (GO:0032981)2.78711500
100NADH dehydrogenase complex assembly (GO:0010257)2.78711500
101phosphatidylglycerol biosynthetic process (GO:0006655)2.78509117
102muscle atrophy (GO:0014889)2.77305904
103regulation of acyl-CoA biosynthetic process (GO:0050812)2.76802740
104regulation of action potential (GO:0098900)2.76541878
105basic amino acid transport (GO:0015802)2.76475997
106aromatic amino acid family catabolic process (GO:0009074)2.76178209
107ribosomal small subunit assembly (GO:0000028)2.75771869
108cellular response to exogenous dsRNA (GO:0071360)2.74334863
109glucan biosynthetic process (GO:0009250)2.73951124
110glycogen biosynthetic process (GO:0005978)2.73951124
111cellular ketone body metabolic process (GO:0046950)2.72684496
112regulation of hippo signaling (GO:0035330)2.72494244
113response to interferon-alpha (GO:0035455)2.71504430
114quinone metabolic process (GO:1901661)2.68305189
115tryptophan metabolic process (GO:0006568)2.67503754
116protein localization to cilium (GO:0061512)2.64638011
117regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64385757
118lipid oxidation (GO:0034440)2.64122660
119negative regulation of synaptic transmission, GABAergic (GO:0032229)2.63910786
120fatty acid catabolic process (GO:0009062)2.63702708
121fatty acid oxidation (GO:0019395)2.63699271
122neuromuscular synaptic transmission (GO:0007274)2.63003903
123defense response to protozoan (GO:0042832)2.62887443
124pyrimidine nucleoside catabolic process (GO:0046135)2.60294171
125neurotransmitter catabolic process (GO:0042135)2.60083516
126cardiac myofibril assembly (GO:0055003)2.58349759
127RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.58237381
128tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.58237381
129positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.58018969
130energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.57721514
131ATP hydrolysis coupled proton transport (GO:0015991)2.57721514
132muscle adaptation (GO:0043500)2.55242336
133carnitine transmembrane transport (GO:1902603)2.54275285
134regulation of microtubule-based movement (GO:0060632)2.54232286
135myotube cell development (GO:0014904)2.53955922
136regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.53907528
137positive regulation of gamma-delta T cell activation (GO:0046645)2.53763399
138motile cilium assembly (GO:0044458)2.53467142
139amine catabolic process (GO:0009310)2.53351063
140cellular biogenic amine catabolic process (GO:0042402)2.53351063
141striated muscle adaptation (GO:0014888)2.52686136
142aspartate family amino acid catabolic process (GO:0009068)2.52462170
143cilium or flagellum-dependent cell motility (GO:0001539)2.50796973
144biotin metabolic process (GO:0006768)2.50737278
145positive regulation of natural killer cell differentiation (GO:0032825)2.50528390
146proteasome assembly (GO:0043248)2.49972544
147erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.49890173
148L-phenylalanine metabolic process (GO:0006558)2.49890173
149negative regulation of erythrocyte differentiation (GO:0045647)2.49494768
150creatine metabolic process (GO:0006600)2.48841499
151membrane depolarization during action potential (GO:0086010)2.48737182
152action potential (GO:0001508)2.45895087
153regulation of membrane repolarization (GO:0060306)2.44888265
154muscle fiber development (GO:0048747)2.44218998
155gamma-aminobutyric acid transport (GO:0015812)2.42618601
156regulation of glycogen (starch) synthase activity (GO:2000465)2.40660468
157response to inactivity (GO:0014854)2.39914197
158establishment of mitochondrion localization (GO:0051654)2.38479780
159somite development (GO:0061053)2.37672598
160synapse assembly (GO:0007416)2.37331174
161pyrimidine dimer repair (GO:0006290)2.36557238
162regulation of collateral sprouting (GO:0048670)2.35632307
163membrane tubulation (GO:0097320)2.34440213
164inositol phosphate catabolic process (GO:0071545)2.33492221
165inner ear receptor stereocilium organization (GO:0060122)2.33376973
166startle response (GO:0001964)2.33250754
167positive regulation of action potential (GO:0045760)2.31695757
168ketone body metabolic process (GO:1902224)2.31686455
169response to muscle activity (GO:0014850)2.31359386
170C-terminal protein amino acid modification (GO:0018410)2.30150561
171C-terminal protein lipidation (GO:0006501)2.28893759
172peroxisome fission (GO:0016559)2.27630054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.96061904
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.12129861
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.01555442
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.47398131
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.97600872
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.29027628
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.25189310
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.16123590
9ZNF274_21170338_ChIP-Seq_K562_Hela3.11114368
10SRF_21415370_ChIP-Seq_HL-1_Mouse2.94893533
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.94787795
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.93735931
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93014591
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.78618350
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.70853750
16EZH2_22144423_ChIP-Seq_EOC_Human2.56070574
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55515498
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46418582
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.42877995
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.42593318
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37457594
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37011915
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.36987771
24LXR_22158963_ChIP-Seq_LIVER_Mouse2.17952845
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.16281520
26IGF1R_20145208_ChIP-Seq_DFB_Human2.15345979
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.15256795
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.13818910
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97313703
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94573819
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93410713
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90792313
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89784575
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86484847
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.82196209
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79036237
37SCL_19346495_ChIP-Seq_HPC-7_Human1.78539740
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71782593
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71592196
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70494825
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.69612817
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69556733
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.68398705
44BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.66235142
45REST_21632747_ChIP-Seq_MESCs_Mouse1.64752601
46VDR_22108803_ChIP-Seq_LS180_Human1.63971740
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.63412598
48CTCF_27219007_Chip-Seq_Bcells_Human1.61850799
49P68_20966046_ChIP-Seq_HELA_Human1.61235686
50ERA_21632823_ChIP-Seq_H3396_Human1.59667137
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55789713
52TP53_22573176_ChIP-Seq_HFKS_Human1.52335381
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51905377
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51654535
55DROSHA_22980978_ChIP-Seq_HELA_Human1.51276155
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50149713
57OCT4_20526341_ChIP-Seq_ESCs_Human1.49527672
58E2F1_20622854_ChIP-Seq_HELA_Human1.48023606
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48003403
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46300461
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.45627133
62GBX2_23144817_ChIP-Seq_PC3_Human1.45465753
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44461393
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42932355
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42165980
66PHF8_20622854_ChIP-Seq_HELA_Human1.41170771
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39567524
68SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38434123
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36383684
70IRF1_19129219_ChIP-ChIP_H3396_Human1.35938280
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35470283
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34303147
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32904315
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32483263
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32053436
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31737540
77SPI1_23547873_ChIP-Seq_NB4_Human1.31416868
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.30989389
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.30924036
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30768083
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28952788
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28798463
83FOXP1_21924763_ChIP-Seq_HESCs_Human1.28018569
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26508329
85HOXB7_26014856_ChIP-Seq_BT474_Human1.26163748
86CTCF_20526341_ChIP-Seq_ESCs_Human1.25845833
87P53_21459846_ChIP-Seq_SAOS-2_Human1.25141776
88EED_16625203_ChIP-ChIP_MESCs_Mouse1.25000740
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24986679
90GATA4_21415370_ChIP-Seq_HL-1_Mouse1.24509171
91ETS1_20019798_ChIP-Seq_JURKAT_Human1.24037096
92MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23627754
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23337221
94EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.23319896
95E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21421145
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20786980
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20775156
98GABP_19822575_ChIP-Seq_HepG2_Human1.20156820
99JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19494022
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18272775
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18137158
102GATA1_22025678_ChIP-Seq_K562_Human1.17280215
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17182540
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.16981164
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15847660
106NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14619071
107BCOR_27268052_Chip-Seq_Bcells_Human1.14330895
108TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14011263
109RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13276147
110IRF8_27001747_Chip-Seq_BMDM_Mouse1.13031295
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12967353
112RAC3_21632823_ChIP-Seq_H3396_Human1.12594686
113MYC_19829295_ChIP-Seq_ESCs_Human1.12386673
114NANOG_20526341_ChIP-Seq_ESCs_Human1.12370578
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11479420
116GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11354435
117YY1_22570637_ChIP-Seq_MALME-3M_Human1.11246846
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09941066
119TAF2_19829295_ChIP-Seq_ESCs_Human1.09655569
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09497914
121VDR_23849224_ChIP-Seq_CD4+_Human1.09309287
122GATA3_21878914_ChIP-Seq_MCF-7_Human1.09048619
123BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07460328
124BCL6_27268052_Chip-Seq_Bcells_Human1.06709462
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06466334
126GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06315736
127ESR1_20079471_ChIP-ChIP_T-47D_Human1.05230591
128SA1_27219007_Chip-Seq_Bcells_Human1.05203104
129NCOR_22424771_ChIP-Seq_293T_Human1.04374841
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04336091
131ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03794523
132SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03784946
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03241977
134MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02416951
135RARB_24833708_ChIP-Seq_LIVER_Mouse1.00995743
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00307918
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.99450851
138ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99058095
139ESR1_21235772_ChIP-Seq_MCF-7_Human0.99007140
140SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98581108
141OCT4_19829295_ChIP-Seq_ESCs_Human0.98051400
142TP53_22127205_ChIP-Seq_IMR90_Human0.97921149
143RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97771280
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97401306
145NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97175293
146GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97131928
147P300_27268052_Chip-Seq_Bcells_Human0.96715594
148SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96119073
149TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95836176
150PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94980149
151CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94417606
152SMC4_20622854_ChIP-Seq_HELA_Human0.93773524
153RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92387974
154NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.92151520
155MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92023748
156EZH2_27304074_Chip-Seq_ESCs_Mouse0.91763300
157CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.90764204
158ER_23166858_ChIP-Seq_MCF-7_Human0.90210368
159SOX2_21211035_ChIP-Seq_LN229_Human0.90163963
160GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89311612
161MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88032604
162HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87673388
163FOXH1_21741376_ChIP-Seq_ESCs_Human0.87408453
164SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87141730
165TET1_21451524_ChIP-Seq_MESCs_Mouse0.86105034
166HTT_18923047_ChIP-ChIP_STHdh_Human0.85439731
167EGR1_19032775_ChIP-ChIP_M12_Human0.85294653
168RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85269155
169FOXP3_21729870_ChIP-Seq_TREG_Human0.85024330
170CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84937458
171SPI1_20517297_ChIP-Seq_HL60_Human0.84770895
172RUNX1_22412390_ChIP-Seq_EML_Mouse0.84674659
173PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84590467
174MAF_26560356_Chip-Seq_TH1_Human0.84524268
175EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84520283
176ERG_20517297_ChIP-Seq_VCAP_Human0.84455131
177BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81180428
178AR_20517297_ChIP-Seq_VCAP_Human0.81083877
179CTCF_26484167_Chip-Seq_Bcells_Mouse0.81057827
180PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80523738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.82911136
2MP0000749_muscle_degeneration4.64109833
3MP0002139_abnormal_hepatobiliary_system3.49123158
4MP0004145_abnormal_muscle_electrophysio3.48792664
5MP0003806_abnormal_nucleotide_metabolis3.04112939
6MP0002837_dystrophic_cardiac_calcinosis3.00589547
7MP0000751_myopathy2.61049125
8MP0004036_abnormal_muscle_relaxation2.55916888
9MP0006036_abnormal_mitochondrial_physio2.49474503
10MP0001835_abnormal_antigen_presentation2.43530400
11MP0005423_abnormal_somatic_nervous2.39459334
12MP0002106_abnormal_muscle_physiology2.35716490
13MP0001984_abnormal_olfaction2.26758115
14MP0009697_abnormal_copulation2.26250472
15MP0005330_cardiomyopathy2.24020582
16MP0005085_abnormal_gallbladder_physiolo2.19257219
17MP0001968_abnormal_touch/_nociception2.15084363
18MP0002332_abnormal_exercise_endurance2.14967875
19MP0004130_abnormal_muscle_cell2.14248752
20MP0004084_abnormal_cardiac_muscle2.10352963
21MP0002269_muscular_atrophy2.06940859
22MP0005360_urolithiasis2.04024422
23MP0001529_abnormal_vocalization2.02586878
24MP0002736_abnormal_nociception_after1.97122631
25MP0009785_altered_susceptibility_to1.96282872
26MP0004087_abnormal_muscle_fiber1.96200300
27MP0004510_myositis1.95998563
28MP0002102_abnormal_ear_morphology1.95514648
29MP0006035_abnormal_mitochondrial_morpho1.94531043
30MP0003186_abnormal_redox_activity1.93051434
31MP0000747_muscle_weakness1.92958395
32MP0005365_abnormal_bile_salt1.92606500
33MP0004270_analgesia1.86444722
34MP0008875_abnormal_xenobiotic_pharmacok1.85949718
35MP0001502_abnormal_circadian_rhythm1.85126389
36MP0000013_abnormal_adipose_tissue1.84696251
37MP0000759_abnormal_skeletal_muscle1.79791133
38MP0002653_abnormal_ependyma_morphology1.79133247
39MP0004233_abnormal_muscle_weight1.76472915
40MP0006276_abnormal_autonomic_nervous1.72960180
41MP0005369_muscle_phenotype1.71354038
42MP0002148_abnormal_hypersensitivity_rea1.70116949
43MP0005620_abnormal_muscle_contractility1.66262638
44MP0003191_abnormal_cellular_cholesterol1.65912289
45MP0001853_heart_inflammation1.63375408
46MP0009046_muscle_twitch1.63353567
47MP0004147_increased_porphyrin_level1.62850825
48MP0003724_increased_susceptibility_to1.61791197
49MP0009840_abnormal_foam_cell1.59779555
50MP0000685_abnormal_immune_system1.57900361
51MP0004215_abnormal_myocardial_fiber1.56869347
52MP0003011_delayed_dark_adaptation1.56286423
53MP0000750_abnormal_muscle_regeneration1.54127214
54MP0003195_calcinosis1.50578055
55MP0005319_abnormal_enzyme/_coenzyme1.48664772
56MP0005670_abnormal_white_adipose1.48652348
57MP0005551_abnormal_eye_electrophysiolog1.47719768
58MP0004043_abnormal_pH_regulation1.47716649
59MP0005332_abnormal_amino_acid1.47706641
60MP0003787_abnormal_imprinting1.47218418
61MP0005266_abnormal_metabolism1.44179738
62MP0002972_abnormal_cardiac_muscle1.43530568
63MP0009745_abnormal_behavioral_response1.39762249
64MP0004142_abnormal_muscle_tone1.38886082
65MP0005385_cardiovascular_system_phenoty1.37352250
66MP0001544_abnormal_cardiovascular_syste1.37352250
67MP0008789_abnormal_olfactory_epithelium1.36453144
68MP0002272_abnormal_nervous_system1.36106990
69MP0000427_abnormal_hair_cycle1.34420009
70MP0002822_catalepsy1.33571099
71MP0002876_abnormal_thyroid_physiology1.31549963
72MP0010329_abnormal_lipoprotein_level1.31330752
73MP0005025_abnormal_response_to1.31216881
74MP0003880_abnormal_central_pattern1.31155721
75MP0002572_abnormal_emotion/affect_behav1.29528057
76MP0003828_pulmonary_edema1.25427689
77MP0009764_decreased_sensitivity_to1.24618627
78MP0002734_abnormal_mechanical_nocicepti1.24452726
79MP0003635_abnormal_synaptic_transmissio1.22283933
80MP0001764_abnormal_homeostasis1.21463317
81MP0003436_decreased_susceptibility_to1.21016524
82MP0008872_abnormal_physiological_respon1.20722195
83MP0005671_abnormal_response_to1.20384988
84MP0010630_abnormal_cardiac_muscle1.19366331
85MP0006292_abnormal_olfactory_placode1.19315715
86MP0002064_seizures1.18813527
87MP0005451_abnormal_body_composition1.18351989
88MP0002063_abnormal_learning/memory/cond1.18047822
89MP0005645_abnormal_hypothalamus_physiol1.18006591
90MP0003122_maternal_imprinting1.16245066
91MP0003137_abnormal_impulse_conducting1.14225838
92MP0005584_abnormal_enzyme/coenzyme_acti1.13449476
93MP0005075_abnormal_melanosome_morpholog1.13370373
94MP0004133_heterotaxia1.12479708
95MP0005377_hearing/vestibular/ear_phenot1.12461234
96MP0003878_abnormal_ear_physiology1.12461234
97MP0004782_abnormal_surfactant_physiolog1.12170261
98MP0001486_abnormal_startle_reflex1.12080649
99MP0002234_abnormal_pharynx_morphology1.10684468
100MP0003221_abnormal_cardiomyocyte_apopto1.10466347
101MP0008775_abnormal_heart_ventricle1.09232797
102MP0008469_abnormal_protein_level1.08527370
103MP0000778_abnormal_nervous_system1.08074604
104MP0002419_abnormal_innate_immunity1.06126903
105MP0001800_abnormal_humoral_immune1.04749621
106MP0002735_abnormal_chemical_nociception1.04483554
107MP0004859_abnormal_synaptic_plasticity1.03823052
108MP0006138_congestive_heart_failure1.03744107
109MP0002557_abnormal_social/conspecific_i1.03243246
110MP0005499_abnormal_olfactory_system1.02590285
111MP0005394_taste/olfaction_phenotype1.02590285
112MP0002909_abnormal_adrenal_gland1.02135234
113MP0000609_abnormal_liver_physiology1.01777043
114MP0001790_abnormal_immune_system1.01083927
115MP0005387_immune_system_phenotype1.01083927
116MP0001905_abnormal_dopamine_level1.00766612
117MP0002132_abnormal_respiratory_system1.00366448
118MP0005253_abnormal_eye_physiology1.00077082
119MP0004085_abnormal_heartbeat0.98882661
120MP0003656_abnormal_erythrocyte_physiolo0.97474383
121MP0002067_abnormal_sensory_capabilities0.95965649
122MP0005464_abnormal_platelet_physiology0.95655596
123MP0002723_abnormal_immune_serum0.95027404
124MP0000372_irregular_coat_pigmentation0.94929282
125MP0000026_abnormal_inner_ear0.93436358
126MP0005647_abnormal_sex_gland0.93119383
127MP0002733_abnormal_thermal_nociception0.93048251
128MP0001970_abnormal_pain_threshold0.92633655
129MP0002452_abnormal_antigen_presenting0.91719556
130MP0002971_abnormal_brown_adipose0.91554591
131MP0004885_abnormal_endolymph0.91275381
132MP0000003_abnormal_adipose_tissue0.90757948
133MP0002184_abnormal_innervation0.90430159
134MP0009780_abnormal_chondrocyte_physiolo0.90262138
135MP0002118_abnormal_lipid_homeostasis0.90245071
136MP0004924_abnormal_behavior0.90016186
137MP0005386_behavior/neurological_phenoty0.90016186
138MP0005000_abnormal_immune_tolerance0.89830669
139MP0001986_abnormal_taste_sensitivity0.89667214
140MP0000343_altered_response_to0.88752935
141MP0006082_CNS_inflammation0.88544825
142MP0000049_abnormal_middle_ear0.88056308
143MP0003950_abnormal_plasma_membrane0.87908791
144MP0003879_abnormal_hair_cell0.86350627
145MP0008877_abnormal_DNA_methylation0.85491585
146MP0002752_abnormal_somatic_nervous0.84914229
147MP0001440_abnormal_grooming_behavior0.84222004
148MP0002166_altered_tumor_susceptibility0.83589329
149MP0001485_abnormal_pinna_reflex0.83093528
150MP0003279_aneurysm0.83008119
151MP0005083_abnormal_biliary_tract0.81306322
152MP0005376_homeostasis/metabolism_phenot0.81045497
153MP0002066_abnormal_motor_capabilities/c0.80239131
154MP0005666_abnormal_adipose_tissue0.78736842
155MP0001819_abnormal_immune_cell0.78064475
156MP0002420_abnormal_adaptive_immunity0.76284599
157MP0003763_abnormal_thymus_physiology0.73525451
158MP0009763_increased_sensitivity_to0.72909817
159MP0000598_abnormal_liver_morphology0.72730565
160MP0000689_abnormal_spleen_morphology0.72038009
161MP0003136_yellow_coat_color0.71998526
162MP0002277_abnormal_respiratory_mucosa0.70286618
163MP0004484_altered_response_of0.68778756
164MP0002006_tumorigenesis0.67612922
165MP0005535_abnormal_body_temperature0.67035146

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.69966059
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.47060805
3Exercise-induced myalgia (HP:0003738)5.35517627
4Nemaline bodies (HP:0003798)5.26503167
5Exercise-induced muscle cramps (HP:0003710)5.10934728
6Calf muscle hypertrophy (HP:0008981)4.28886877
7Muscle hypertrophy of the lower extremities (HP:0008968)4.28255994
8Hepatic necrosis (HP:0002605)3.92951898
9Myoglobinuria (HP:0002913)3.79673119
10Hepatocellular necrosis (HP:0001404)3.75784055
11Type 1 muscle fiber predominance (HP:0003803)3.64322512
12Distal arthrogryposis (HP:0005684)3.62021845
13Rhabdomyolysis (HP:0003201)3.41600445
14Abnormal mitochondria in muscle tissue (HP:0008316)3.28014135
15Acute necrotizing encephalopathy (HP:0006965)3.26553164
16Mitochondrial inheritance (HP:0001427)3.23210651
17Abnormality of the left ventricular outflow tract (HP:0011103)3.20277072
18Subaortic stenosis (HP:0001682)3.20277072
19Acute encephalopathy (HP:0006846)3.19716550
20Type 2 muscle fiber atrophy (HP:0003554)3.18654631
21Nonprogressive disorder (HP:0003680)3.17102447
22EMG: myopathic abnormalities (HP:0003458)3.05394701
23Abnormality of the calf musculature (HP:0001430)3.03533506
24Increased CSF lactate (HP:0002490)3.01156441
25Myopathic facies (HP:0002058)2.99792593
26Molar tooth sign on MRI (HP:0002419)2.99655635
27Abnormality of midbrain morphology (HP:0002418)2.99655635
28Medial flaring of the eyebrow (HP:0010747)2.95530234
29Cerebral edema (HP:0002181)2.92644773
30Type II lissencephaly (HP:0007260)2.87504662
31Nephronophthisis (HP:0000090)2.85418944
32Muscle stiffness (HP:0003552)2.83476561
33Muscle fiber splitting (HP:0003555)2.81452392
34Hyperglycinuria (HP:0003108)2.80585506
35Muscle fiber atrophy (HP:0100295)2.80027283
36Exercise intolerance (HP:0003546)2.76198995
37Increased muscle lipid content (HP:0009058)2.73877426
38Asymmetric septal hypertrophy (HP:0001670)2.73780127
39Lactic acidosis (HP:0003128)2.73773861
40Hyperglycinemia (HP:0002154)2.73379599
41Dicarboxylic aciduria (HP:0003215)2.72810020
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72810020
43Weak cry (HP:0001612)2.71193863
44Gait imbalance (HP:0002141)2.69081812
45Increased intramyocellular lipid droplets (HP:0012240)2.68473457
46Progressive macrocephaly (HP:0004481)2.66990723
47Sudden death (HP:0001699)2.59838591
48Abnormality of fatty-acid metabolism (HP:0004359)2.59762004
49Hyperventilation (HP:0002883)2.58896970
50Pancreatic cysts (HP:0001737)2.58534920
51Abnormality of the neuromuscular junction (HP:0003398)2.57817452
52Fatigable weakness (HP:0003473)2.57817452
53Myotonia (HP:0002486)2.54859599
54Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52521866
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52521866
56Nephrogenic diabetes insipidus (HP:0009806)2.51824695
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.51626096
58Hyporeflexia of lower limbs (HP:0002600)2.49518778
59Lipoatrophy (HP:0100578)2.49020113
60Abnormality of the renal medulla (HP:0100957)2.48340066
61Bulbar palsy (HP:0001283)2.47423717
62Pancreatic fibrosis (HP:0100732)2.46899437
63Congenital primary aphakia (HP:0007707)2.45942326
64Hyperammonemia (HP:0001987)2.41884044
65Ventricular tachycardia (HP:0004756)2.41840506
66Ragged-red muscle fibers (HP:0003200)2.41542519
67Areflexia of lower limbs (HP:0002522)2.41112451
68Dilated cardiomyopathy (HP:0001644)2.38875522
69Lethargy (HP:0001254)2.38866623
70Increased serum lactate (HP:0002151)2.38208098
71Abnormality of glycine metabolism (HP:0010895)2.37834704
72Abnormality of serine family amino acid metabolism (HP:0010894)2.37834704
73Increased connective tissue (HP:0009025)2.35877251
74Fetal akinesia sequence (HP:0001989)2.35227165
75Rimmed vacuoles (HP:0003805)2.33686214
76Lissencephaly (HP:0001339)2.31567864
77Round ear (HP:0100830)2.31484711
78Difficulty running (HP:0009046)2.30091106
79Congenital stationary night blindness (HP:0007642)2.30044530
803-Methylglutaconic aciduria (HP:0003535)2.29378290
81Left ventricular hypertrophy (HP:0001712)2.29110410
82Neck muscle weakness (HP:0000467)2.28913441
83Type I transferrin isoform profile (HP:0003642)2.28380850
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.27967702
85Abnormal respiratory motile cilium morphology (HP:0005938)2.27551595
86Abnormal respiratory epithelium morphology (HP:0012253)2.27551595
87Generalized aminoaciduria (HP:0002909)2.27226947
88Severe muscular hypotonia (HP:0006829)2.26953697
89Abnormality of serum amino acid levels (HP:0003112)2.26400435
90Ulnar deviation of the wrist (HP:0003049)2.25806887
91Malignant hyperthermia (HP:0002047)2.25179230
92Cerebellar dysplasia (HP:0007033)2.24792104
93Palpitations (HP:0001962)2.24564887
94Esophageal neoplasm (HP:0100751)2.20615531
95Neoplasm of head and neck (HP:0012288)2.20615531
96Autoimmune thrombocytopenia (HP:0001973)2.20561291
97Lipid accumulation in hepatocytes (HP:0006561)2.19303933
98EMG: neuropathic changes (HP:0003445)2.18942468
99Dynein arm defect of respiratory motile cilia (HP:0012255)2.17878569
100Absent/shortened dynein arms (HP:0200106)2.17878569
101Atrial fibrillation (HP:0005110)2.16597713
102Metabolic acidosis (HP:0001942)2.16380538
103Frequent falls (HP:0002359)2.14560278
104Distal lower limb muscle weakness (HP:0009053)2.12105496
105Hypoglycemic coma (HP:0001325)2.12004722
106True hermaphroditism (HP:0010459)2.09820097
107Abnormality of the renal cortex (HP:0011035)2.09743329
108Retinal dysplasia (HP:0007973)2.09633464
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09401237
110Abnormality of alanine metabolism (HP:0010916)2.09401237
111Hyperalaninemia (HP:0003348)2.09401237
112Atrioventricular block (HP:0001678)2.09027288
113Hypoplastic heart (HP:0001961)2.07168514
114Respiratory failure (HP:0002878)2.05732420
115Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05710948
116Increased hepatocellular lipid droplets (HP:0006565)2.03090360
117Progressive muscle weakness (HP:0003323)2.02938268
118Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02404482
119Limb-girdle muscle atrophy (HP:0003797)1.99471954
120Absent phalangeal crease (HP:0006109)1.99441161
121Heart block (HP:0012722)1.98922152
122Abnormal drinking behavior (HP:0030082)1.98391632
123Polydipsia (HP:0001959)1.98391632
124Abnormality of skeletal muscle fiber size (HP:0012084)1.98226178
125Easy fatigability (HP:0003388)1.97833863
126Prolonged partial thromboplastin time (HP:0003645)1.95912671
127Pendular nystagmus (HP:0012043)1.95892154
128Pachygyria (HP:0001302)1.95890264
129Hypoplastic left heart (HP:0004383)1.95651355
130Hypoplasia of the brainstem (HP:0002365)1.94857433
131Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94857433
132Abnormal finger flexion creases (HP:0006143)1.94765105
133Supraventricular tachycardia (HP:0004755)1.93962845
134Increased IgM level (HP:0003496)1.93931953
135Primary atrial arrhythmia (HP:0001692)1.92840991
136Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92734341
137Calcaneovalgus deformity (HP:0001848)1.92615830
138Ketosis (HP:0001946)1.92566426
139Absent speech (HP:0001344)1.86243874
140Concave nail (HP:0001598)1.84935723
141Congenital hepatic fibrosis (HP:0002612)1.84210270
142Prolonged QT interval (HP:0001657)1.83870621
143Inability to walk (HP:0002540)1.81248364
144Generalized muscle weakness (HP:0003324)1.80376411
145Tubulointerstitial nephritis (HP:0001970)1.78660311
146Broad-based gait (HP:0002136)1.77612329
147Attenuation of retinal blood vessels (HP:0007843)1.77407720
148Polyphagia (HP:0002591)1.74501860
149Delayed gross motor development (HP:0002194)1.74142140
150Cystic liver disease (HP:0006706)1.71646006
151Sclerocornea (HP:0000647)1.71007197
152Poor coordination (HP:0002370)1.70922028
153Vaginal atresia (HP:0000148)1.69657675
154Abnormal respiratory motile cilium physiology (HP:0012261)1.69571329
155Hip dysplasia (HP:0001385)1.69306071
156Genital tract atresia (HP:0001827)1.69170576
157Abnormal ciliary motility (HP:0012262)1.68677705
158Tented upper lip vermilion (HP:0010804)1.67886114

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK6.76607028
2OBSCN5.02797550
3MAP4K23.39155513
4BCKDK3.29818744
5NME22.63249314
6MARK12.60441288
7PINK12.47126767
8TTN2.43909527
9MAP3K142.37648263
10PHKG22.33503726
11PHKG12.33503726
12EPHA22.32338059
13MAPK152.18788468
14IRAK32.06464644
15MYLK2.04094461
16DAPK21.94229325
17TLK11.93284347
18MAP3K41.88429919
19PRPF4B1.83606209
20MAPK131.81598572
21ZAK1.78878954
22MAP3K111.72056389
23NEK91.69992759
24CSNK1G31.67132581
25TXK1.64553844
26CSNK1A1L1.64244324
27MAP2K31.60968865
28LIMK11.58884385
29CASK1.50410800
30PIK3CG1.48444380
31WNK41.48119567
32TRIM281.48056546
33CSNK1G21.47492066
34TIE11.44514272
35IKBKB1.41725671
36FRK1.40244418
37MAPK121.36836866
38TBK11.36336275
39CSNK1G11.34777032
40PIK3CA1.30869126
41PRKG21.30044503
42IKBKE1.29478229
43AKT31.26708867
44DYRK21.25632215
45GRK11.25035742
46MAPKAPK31.23055308
47NME11.22237478
48MAP4K11.21918746
49PDK41.21151712
50PDK31.21151712
51PIM21.21041973
52KIT1.18146095
53IRAK41.15903658
54STK241.15587122
55INSRR1.13780467
56BCR1.10394838
57PDK21.10251791
58PAK31.09115264
59PAK61.06277195
60SIK21.04878187
61WNK31.01953931
62MKNK21.01912228
63MAP2K70.97400656
64MAP2K60.92826979
65ACVR1B0.90380489
66TEC0.89667521
67FLT30.89257284
68ADRBK10.87653094
69MAP3K90.86327692
70PIM10.85416512
71TAOK20.84101257
72JAK30.82638946
73BLK0.82392984
74TGFBR10.81209871
75LMTK20.79824690
76BTK0.77615591
77BMPR1B0.76609218
78ZAP700.75453358
79PRKCG0.75062358
80TYK20.74997290
81VRK20.72980504
82TRPM70.71940987
83SGK20.71245846
84SRPK10.70894443
85DYRK1B0.69951234
86PRKCI0.69117421
87CHUK0.68711012
88MKNK10.68298096
89SYK0.68251661
90TGFBR20.67287104
91MAP3K70.66361470
92TRIB30.66348752
93YES10.65874571
94ERN10.65624212
95EIF2AK20.65281098
96PRKAA20.64979101
97MAPK110.64482485
98EPHA30.64292702
99GRK70.63875818
100CAMK2A0.63410068
101ABL20.63393479
102DAPK10.63235204
103RPS6KA60.62466806
104STK40.62015723
105EPHA40.61952455
106MAP2K10.61665884
107PRKCE0.60841745
108DAPK30.60503675
109BRSK20.59890614
110NUAK10.58774114
111LYN0.58119090
112RPS6KL10.56145000
113RPS6KC10.56145000
114MAP2K40.55527090
115STK160.55504204
116MAP3K120.54233390
117STK38L0.54060377
118ADRBK20.52870734
119PRKCZ0.52714135
120VRK10.52461246
121MINK10.50681409
122CAMK2D0.49303243
123MAP3K60.48353751
124KDR0.47840437
125TAOK30.47746624
126MARK20.47315236
127CDK190.47123468
128CSF1R0.45793279
129CSNK1A10.45641186
130MATK0.45303781
131PRKACA0.45214165
132CAMK2B0.44264337
133MAPK40.43785115
134MAPK70.43679830
135OXSR10.42973378
136AURKA0.42705823
137CDK80.42427002
138SGK30.42404555
139STK380.42330254
140BMPR20.42097442
141EPHB20.41365181
142PKN10.41214210
143ILK0.38955816
144TNIK0.38627446
145CAMK10.38604968
146SGK4940.38459775
147SGK2230.38459775
148CAMK40.38405150
149RPS6KA50.38236762
150CSNK1D0.37207978
151TAF10.36733346
152EIF2AK30.36668188
153GRK50.35925276
154CAMKK20.34898199
155PRKAA10.34813903
156RPS6KA20.34567769
157ERBB30.34428622
158TESK20.34125047
159RPS6KA40.33888804
160ERBB40.33515435
161PRKD20.33508771
162PTK2B0.33224520
163NEK10.32953317
164SIK10.32892864
165SIK30.32754152
166CAMK2G0.32639166
167PRKCD0.31647004

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.27651997
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.84291643
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.81567697
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.64273128
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.61207011
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56779582
7Propanoate metabolism_Homo sapiens_hsa006402.52121600
8Fatty acid degradation_Homo sapiens_hsa000712.51024982
9Phototransduction_Homo sapiens_hsa047442.42429978
10Oxidative phosphorylation_Homo sapiens_hsa001902.42026218
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.33062126
12Parkinsons disease_Homo sapiens_hsa050122.30525610
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18417071
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.17313480
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.14374012
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00504175
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95173201
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90551805
19Peroxisome_Homo sapiens_hsa041461.88405351
20Caffeine metabolism_Homo sapiens_hsa002321.86608042
21Carbon metabolism_Homo sapiens_hsa012001.85867955
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67459502
23Cardiac muscle contraction_Homo sapiens_hsa042601.66960930
24Nicotine addiction_Homo sapiens_hsa050331.65544483
25Proteasome_Homo sapiens_hsa030501.62487192
26Fatty acid metabolism_Homo sapiens_hsa012121.54538466
27Alzheimers disease_Homo sapiens_hsa050101.53363198
28Synaptic vesicle cycle_Homo sapiens_hsa047211.51689981
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51534218
30Linoleic acid metabolism_Homo sapiens_hsa005911.49501840
31Tryptophan metabolism_Homo sapiens_hsa003801.47273523
32Collecting duct acid secretion_Homo sapiens_hsa049661.47273145
33Nitrogen metabolism_Homo sapiens_hsa009101.44879329
34Graft-versus-host disease_Homo sapiens_hsa053321.43900464
35Huntingtons disease_Homo sapiens_hsa050161.43562775
36Arginine biosynthesis_Homo sapiens_hsa002201.41943918
37Fatty acid elongation_Homo sapiens_hsa000621.41628374
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37758034
39Allograft rejection_Homo sapiens_hsa053301.36015131
40Pyruvate metabolism_Homo sapiens_hsa006201.34482956
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34186667
42Staphylococcus aureus infection_Homo sapiens_hsa051501.32298411
43beta-Alanine metabolism_Homo sapiens_hsa004101.30538370
44Starch and sucrose metabolism_Homo sapiens_hsa005001.28809197
45Regulation of autophagy_Homo sapiens_hsa041401.26867668
46Chemical carcinogenesis_Homo sapiens_hsa052041.25806990
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.24837176
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24339180
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22854486
50PPAR signaling pathway_Homo sapiens_hsa033201.22810036
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.22102849
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20618557
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20174150
54Folate biosynthesis_Homo sapiens_hsa007901.19604793
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19000081
56Complement and coagulation cascades_Homo sapiens_hsa046101.18090494
57Galactose metabolism_Homo sapiens_hsa000521.15546185
58Fructose and mannose metabolism_Homo sapiens_hsa000511.14564181
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13854931
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13812198
61Biosynthesis of amino acids_Homo sapiens_hsa012301.13798016
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12710562
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12123396
64Insulin secretion_Homo sapiens_hsa049111.07130971
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02779728
66Ether lipid metabolism_Homo sapiens_hsa005651.01519444
67Phenylalanine metabolism_Homo sapiens_hsa003600.99431900
68Ribosome_Homo sapiens_hsa030100.96972823
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.96601033
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.96027350
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95283642
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94786297
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93045890
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92125803
75Butanoate metabolism_Homo sapiens_hsa006500.91585483
76RNA polymerase_Homo sapiens_hsa030200.90253231
77Calcium signaling pathway_Homo sapiens_hsa040200.89988950
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89283169
79ABC transporters_Homo sapiens_hsa020100.88053073
80Arginine and proline metabolism_Homo sapiens_hsa003300.86529417
81Sulfur relay system_Homo sapiens_hsa041220.84635826
82Primary immunodeficiency_Homo sapiens_hsa053400.82126996
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80544327
84GABAergic synapse_Homo sapiens_hsa047270.80174365
85Dilated cardiomyopathy_Homo sapiens_hsa054140.78898833
86Metabolic pathways_Homo sapiens_hsa011000.78470117
87Legionellosis_Homo sapiens_hsa051340.78467664
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.77722946
89Selenocompound metabolism_Homo sapiens_hsa004500.77222245
90Sulfur metabolism_Homo sapiens_hsa009200.76043109
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.75607065
92Taste transduction_Homo sapiens_hsa047420.74035345
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73883787
94Histidine metabolism_Homo sapiens_hsa003400.72971516
95Circadian entrainment_Homo sapiens_hsa047130.72892558
96Tyrosine metabolism_Homo sapiens_hsa003500.72754754
97Pyrimidine metabolism_Homo sapiens_hsa002400.72477198
98Base excision repair_Homo sapiens_hsa034100.71787756
99Glucagon signaling pathway_Homo sapiens_hsa049220.69723713
100Measles_Homo sapiens_hsa051620.68307342
101Dopaminergic synapse_Homo sapiens_hsa047280.68155286
102Autoimmune thyroid disease_Homo sapiens_hsa053200.67459859
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67400209
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65451640
105Retinol metabolism_Homo sapiens_hsa008300.64949386
106Basal transcription factors_Homo sapiens_hsa030220.63207159
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.62060730
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62040196
109Morphine addiction_Homo sapiens_hsa050320.61469140
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59957043
111Tight junction_Homo sapiens_hsa045300.58755617
112Axon guidance_Homo sapiens_hsa043600.57331070
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.57113195
114Ovarian steroidogenesis_Homo sapiens_hsa049130.57063777
115Protein export_Homo sapiens_hsa030600.56933968
116Leishmaniasis_Homo sapiens_hsa051400.56827470
117Oxytocin signaling pathway_Homo sapiens_hsa049210.55318041
118Pentose phosphate pathway_Homo sapiens_hsa000300.54104681
119Herpes simplex infection_Homo sapiens_hsa051680.52986287
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.52904302
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52619691
122Insulin resistance_Homo sapiens_hsa049310.51501774
123Glutamatergic synapse_Homo sapiens_hsa047240.51158773
124Serotonergic synapse_Homo sapiens_hsa047260.50315401
125One carbon pool by folate_Homo sapiens_hsa006700.48344513
126Influenza A_Homo sapiens_hsa051640.47830500
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46969868
128Purine metabolism_Homo sapiens_hsa002300.43937309
129Arachidonic acid metabolism_Homo sapiens_hsa005900.43176015
130Cocaine addiction_Homo sapiens_hsa050300.43004451
131Olfactory transduction_Homo sapiens_hsa047400.42929545
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42560994
133Salivary secretion_Homo sapiens_hsa049700.42147952
134Vibrio cholerae infection_Homo sapiens_hsa051100.39642630
135Glycerolipid metabolism_Homo sapiens_hsa005610.38488080
136Pertussis_Homo sapiens_hsa051330.37787618
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37464224
138AMPK signaling pathway_Homo sapiens_hsa041520.37112044
139Hippo signaling pathway_Homo sapiens_hsa043900.37064394
140Steroid biosynthesis_Homo sapiens_hsa001000.36951281
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36806450
142Viral myocarditis_Homo sapiens_hsa054160.36460602
143Sphingolipid metabolism_Homo sapiens_hsa006000.36398316
144Glutathione metabolism_Homo sapiens_hsa004800.34403052
145Circadian rhythm_Homo sapiens_hsa047100.32025409
146Fatty acid biosynthesis_Homo sapiens_hsa000610.29991963

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