MIEN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.60996557
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.36220927
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.29677679
4ATP synthesis coupled proton transport (GO:0015986)6.29677679
5respiratory electron transport chain (GO:0022904)5.54220544
6electron transport chain (GO:0022900)5.43038459
7protein neddylation (GO:0045116)5.02218038
8chaperone-mediated protein transport (GO:0072321)4.97783990
9negative regulation of T cell differentiation in thymus (GO:0033085)4.78577516
10DNA deamination (GO:0045006)4.44627677
11fatty acid elongation (GO:0030497)4.38304741
12protein complex biogenesis (GO:0070271)4.33725663
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.22577342
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.22577342
15NADH dehydrogenase complex assembly (GO:0010257)4.22577342
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.15291781
17pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.01013802
18proteasome assembly (GO:0043248)3.94029926
19hydrogen ion transmembrane transport (GO:1902600)3.82490910
20mitochondrial respiratory chain complex assembly (GO:0033108)3.81283960
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.75747091
22axon ensheathment in central nervous system (GO:0032291)3.74181763
23central nervous system myelination (GO:0022010)3.74181763
24water-soluble vitamin biosynthetic process (GO:0042364)3.69271761
25iron-sulfur cluster assembly (GO:0016226)3.67492405
26metallo-sulfur cluster assembly (GO:0031163)3.67492405
27positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.62110628
28respiratory chain complex IV assembly (GO:0008535)3.56709894
29regulation of cellular amino acid metabolic process (GO:0006521)3.54186360
30regulation of female receptivity (GO:0045924)3.52677592
31positive regulation of ligase activity (GO:0051351)3.50962302
32female mating behavior (GO:0060180)3.50696154
33proton transport (GO:0015992)3.50113255
34energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.47815508
35ATP hydrolysis coupled proton transport (GO:0015991)3.47815508
36signal peptide processing (GO:0006465)3.46952641
37base-excision repair, AP site formation (GO:0006285)3.45736284
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.42482657
39hydrogen transport (GO:0006818)3.42465010
40ATP biosynthetic process (GO:0006754)3.37242144
41cholesterol biosynthetic process (GO:0006695)3.29946631
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.28075917
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.26847006
44pyrimidine nucleotide catabolic process (GO:0006244)3.25249532
45pseudouridine synthesis (GO:0001522)3.24697811
46platelet dense granule organization (GO:0060155)3.22794382
47regulation of oxidative phosphorylation (GO:0002082)3.21128308
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.20371532
49long-chain fatty acid biosynthetic process (GO:0042759)3.18047984
50positive regulation of cell cycle arrest (GO:0071158)3.15818747
51dopamine transport (GO:0015872)3.12884038
52DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.12716727
53aldehyde catabolic process (GO:0046185)3.11074002
54regulation of ubiquitin-protein transferase activity (GO:0051438)3.09742272
55cytochrome complex assembly (GO:0017004)3.07464262
56GDP-mannose metabolic process (GO:0019673)3.06983100
57regulation of cellular amine metabolic process (GO:0033238)3.05289852
58transferrin transport (GO:0033572)3.03787806
59regulation of transcription from RNA polymerase I promoter (GO:0006356)3.03406133
60regulation of ligase activity (GO:0051340)3.02708105
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.02062729
62pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.97516299
63protein targeting to mitochondrion (GO:0006626)2.97219466
64GTP biosynthetic process (GO:0006183)2.95994120
65transcription elongation from RNA polymerase III promoter (GO:0006385)2.95489190
66termination of RNA polymerase III transcription (GO:0006386)2.95489190
67substantia nigra development (GO:0021762)2.95434636
68dopamine biosynthetic process (GO:0042416)2.93729772
69deoxyribonucleotide catabolic process (GO:0009264)2.93192173
70sterol biosynthetic process (GO:0016126)2.92998404
71cullin deneddylation (GO:0010388)2.90583931
72GPI anchor metabolic process (GO:0006505)2.90382378
73negative regulation of protein ubiquitination (GO:0031397)2.89911716
74RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88987491
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88987491
76negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.88850232
77regulation of catecholamine metabolic process (GO:0042069)2.88152252
78regulation of dopamine metabolic process (GO:0042053)2.88152252
79establishment of protein localization to mitochondrion (GO:0072655)2.87948409
80anterograde synaptic vesicle transport (GO:0048490)2.86346702
81oxidative phosphorylation (GO:0006119)2.86023982
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83320423
83ribonucleoside triphosphate biosynthetic process (GO:0009201)2.82069988
84antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80605485
85rRNA modification (GO:0000154)2.80283608
86dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.80274186
87deoxyribose phosphate catabolic process (GO:0046386)2.79579137
88ferric iron transport (GO:0015682)2.79273019
89trivalent inorganic cation transport (GO:0072512)2.79273019
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.78781639
91L-phenylalanine metabolic process (GO:0006558)2.78781639
92regulation of cell cycle arrest (GO:0071156)2.78298116
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77872426
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77553770
95negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.76581930
96positive regulation of mitochondrial fission (GO:0090141)2.74843103
97keratinocyte development (GO:0003334)2.73163426
98lactate metabolic process (GO:0006089)2.71477466
99protein maturation by protein folding (GO:0022417)2.71005230
100isoprenoid biosynthetic process (GO:0008299)2.70393812
101protein localization to mitochondrion (GO:0070585)2.69648500
102protein deneddylation (GO:0000338)2.68088611
103signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67779414
104signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67779414
105signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67779414
106signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.67730326
107intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.67730326
108intracellular protein transmembrane import (GO:0044743)2.67598201
109regulation of mitochondrial translation (GO:0070129)2.65493081
110GPI anchor biosynthetic process (GO:0006506)2.64799401
111negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.63305222
112nucleotide transmembrane transport (GO:1901679)2.62199806
113phagosome maturation (GO:0090382)2.59851920
114peptidyl-histidine modification (GO:0018202)2.58994326
115mannosylation (GO:0097502)2.57942844
116L-methionine salvage (GO:0071267)2.57217557
117L-methionine biosynthetic process (GO:0071265)2.57217557
118amino acid salvage (GO:0043102)2.57217557
119nucleoside triphosphate biosynthetic process (GO:0009142)2.56862161
120signal transduction involved in DNA integrity checkpoint (GO:0072401)2.55452699
121signal transduction involved in DNA damage checkpoint (GO:0072422)2.55452699
122mitochondrial transport (GO:0006839)2.55319905
123negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.54907397
124negative regulation of ligase activity (GO:0051352)2.54907397
125positive regulation of cellular amine metabolic process (GO:0033240)2.54666319
126guanosine-containing compound biosynthetic process (GO:1901070)2.53591617
127signal transduction involved in cell cycle checkpoint (GO:0072395)2.52985946
128erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.52487298
129L-phenylalanine catabolic process (GO:0006559)2.52487298
130glutathione biosynthetic process (GO:0006750)2.49966598
131inner mitochondrial membrane organization (GO:0007007)2.49407874
132mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.49168576
133ER overload response (GO:0006983)2.46956724
1347-methylguanosine mRNA capping (GO:0006370)2.45498272
135positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44843079
136protein-cofactor linkage (GO:0018065)2.43846313
137amyloid precursor protein metabolic process (GO:0042982)2.42649065
138response to redox state (GO:0051775)2.41980345
1397-methylguanosine RNA capping (GO:0009452)2.41147511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.96742671
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.65771579
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65694014
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.52045186
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.46329723
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.19804680
7PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.04330318
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.92469848
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76792633
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.65103053
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.62463113
12VDR_22108803_ChIP-Seq_LS180_Human2.61499682
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45126353
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41031424
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.39200038
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.19328292
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.19005619
18FOXP3_21729870_ChIP-Seq_TREG_Human1.99923524
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99007365
20EZH2_22144423_ChIP-Seq_EOC_Human1.86776652
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81043580
22XRN2_22483619_ChIP-Seq_HELA_Human1.79740967
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78192122
24ZNF263_19887448_ChIP-Seq_K562_Human1.78067278
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72993356
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72003195
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69530160
28TAF15_26573619_Chip-Seq_HEK293_Human1.67381715
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.66243229
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.66028496
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63342215
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58020814
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57626625
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57570092
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.52918494
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52216352
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.51190601
38KDM5A_27292631_Chip-Seq_BREAST_Human1.49551355
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49464757
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45836406
41GBX2_23144817_ChIP-Seq_PC3_Human1.42175146
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.41558601
43TTF2_22483619_ChIP-Seq_HELA_Human1.38378665
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37670373
45DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36282222
46IRF1_19129219_ChIP-ChIP_H3396_Human1.36135112
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33723164
48VDR_23849224_ChIP-Seq_CD4+_Human1.32956952
49TFEB_21752829_ChIP-Seq_HELA_Human1.31010876
50ELF5_23300383_ChIP-Seq_T47D_Human1.29840062
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29435114
52CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.29418780
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.29055132
54FOXP1_21924763_ChIP-Seq_HESCs_Human1.27982121
55DCP1A_22483619_ChIP-Seq_HELA_Human1.22904116
56FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22174475
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22164284
58HTT_18923047_ChIP-ChIP_STHdh_Human1.19255579
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18908573
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18195069
61TBX5_21415370_ChIP-Seq_HL-1_Mouse1.17601684
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15167571
63REST_21632747_ChIP-Seq_MESCs_Mouse1.14853668
64ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14690408
65BCL6_27268052_Chip-Seq_Bcells_Human1.14624153
66MYC_18940864_ChIP-ChIP_HL60_Human1.13625332
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12059296
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11576347
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09731095
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09627733
71YY1_22570637_ChIP-Seq_MALME-3M_Human1.09388218
72IGF1R_20145208_ChIP-Seq_DFB_Human1.09165049
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08664373
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08373590
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07390681
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06229800
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.06003090
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05613814
79BCOR_27268052_Chip-Seq_Bcells_Human1.05554520
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.03717377
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03165203
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02134729
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02025160
84CTCF_20526341_ChIP-Seq_ESCs_Human1.01970266
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01447133
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01352130
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01012470
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00523231
89CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00200864
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00038722
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00001622
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99822836
93ELK1_19687146_ChIP-ChIP_HELA_Human0.99273120
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99060633
95ER_23166858_ChIP-Seq_MCF-7_Human0.97758235
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97159190
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96960667
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96728105
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95673042
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95615898
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95202703
102EZH2_27304074_Chip-Seq_ESCs_Mouse0.95174676
103CTCF_26484167_Chip-Seq_Bcells_Mouse0.94910558
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94480194
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93891097
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93198977
107MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92456671
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92367543
109RARB_24833708_ChIP-Seq_LIVER_Mouse0.92069600
110JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91963426
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90851246
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90598732
113LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90503145
114SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90471101
115GABP_19822575_ChIP-Seq_HepG2_Human0.90405328
116REST_19997604_ChIP-ChIP_NEURONS_Mouse0.90361132
117TP53_22573176_ChIP-Seq_HFKS_Human0.90286298
118SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89613864
119NCOR_22424771_ChIP-Seq_293T_Human0.89537249
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88741050
121P300_19829295_ChIP-Seq_ESCs_Human0.88719843
122EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88458026
123BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88375350
124ERA_21632823_ChIP-Seq_H3396_Human0.87290666
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87137746
126JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87113841
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87106581
128SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87040374
129SOX2_19829295_ChIP-Seq_ESCs_Human0.86221473
130NANOG_19829295_ChIP-Seq_ESCs_Human0.86221473
131P53_21459846_ChIP-Seq_SAOS-2_Human0.85416747
132E2F1_20622854_ChIP-Seq_HELA_Human0.85377671
133PHF8_20622854_ChIP-Seq_HELA_Human0.84189479
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84050174
135P68_20966046_ChIP-Seq_HELA_Human0.83982172
136HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83733665
137PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83617328
138EOMES_21245162_ChIP-Seq_HESCs_Human0.83314801
139NANOG_20526341_ChIP-Seq_ESCs_Human0.83229893
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83114990
141CBX2_27304074_Chip-Seq_ESCs_Mouse0.80909606
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80863206
143EZH2_27294783_Chip-Seq_ESCs_Mouse0.79638629
144MTF2_20144788_ChIP-Seq_MESCs_Mouse0.79529833
145SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78392028
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78242031
147FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.76941048
148RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76908256
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76525769
150PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76354144
151CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.75691405
152EED_16625203_ChIP-ChIP_MESCs_Mouse0.75235484
153CDX2_19796622_ChIP-Seq_MESCs_Mouse0.75060097
154FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.74919385
155BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74788519
156STAT1_20625510_ChIP-Seq_HELA_Human0.74684057
157SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.74576993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.61583648
2MP0001529_abnormal_vocalization2.99225437
3MP0001905_abnormal_dopamine_level2.92476887
4MP0003195_calcinosis2.79968428
5MP0003786_premature_aging2.48433132
6MP0006276_abnormal_autonomic_nervous2.39953045
7MP0004270_analgesia2.36663214
8MP0003806_abnormal_nucleotide_metabolis2.28369788
9MP0002653_abnormal_ependyma_morphology2.14828584
10MP0002132_abnormal_respiratory_system2.11562972
11MP0002876_abnormal_thyroid_physiology2.07930641
12MP0004043_abnormal_pH_regulation2.04126760
13MP0010386_abnormal_urinary_bladder2.02412537
14MP0002735_abnormal_chemical_nociception2.01262885
15MP0001986_abnormal_taste_sensitivity1.99989537
16MP0002734_abnormal_mechanical_nocicepti1.99281631
17MP0006036_abnormal_mitochondrial_physio1.98447191
18MP0000920_abnormal_myelination1.98199796
19MP0001984_abnormal_olfaction1.96527823
20MP0003186_abnormal_redox_activity1.95179139
21MP0002272_abnormal_nervous_system1.93016784
22MP0009780_abnormal_chondrocyte_physiolo1.90409927
23MP0001968_abnormal_touch/_nociception1.89644903
24MP0009379_abnormal_foot_pigmentation1.86004906
25MP0008058_abnormal_DNA_repair1.85432893
26MP0001970_abnormal_pain_threshold1.81454616
27MP0002736_abnormal_nociception_after1.78973945
28MP0004142_abnormal_muscle_tone1.78860191
29MP0002064_seizures1.71680277
30MP0008260_abnormal_autophagy1.67618729
31MP0002638_abnormal_pupillary_reflex1.67234085
32MP0002822_catalepsy1.66265647
33MP0003123_paternal_imprinting1.65046076
34MP0005379_endocrine/exocrine_gland_phen1.64098271
35MP0002733_abnormal_thermal_nociception1.63881084
36MP0002138_abnormal_hepatobiliary_system1.60586997
37MP0003136_yellow_coat_color1.57542518
38MP0002277_abnormal_respiratory_mucosa1.57485564
39MP0001440_abnormal_grooming_behavior1.55914985
40MP0005451_abnormal_body_composition1.54910922
41MP0009785_altered_susceptibility_to1.54834594
42MP0000372_irregular_coat_pigmentation1.54409751
43MP0008875_abnormal_xenobiotic_pharmacok1.54101478
44MP0009745_abnormal_behavioral_response1.53855922
45MP0002572_abnormal_emotion/affect_behav1.52535973
46MP0003693_abnormal_embryo_hatching1.50574096
47MP0003329_amyloid_beta_deposits1.49910016
48MP0002837_dystrophic_cardiac_calcinosis1.46587269
49MP0002139_abnormal_hepatobiliary_system1.44411216
50MP0005058_abnormal_lysosome_morphology1.42307543
51MP0006035_abnormal_mitochondrial_morpho1.41133272
52MP0002163_abnormal_gland_morphology1.40982010
53MP0004147_increased_porphyrin_level1.40875400
54MP0003635_abnormal_synaptic_transmissio1.39458626
55MP0005636_abnormal_mineral_homeostasis1.39219161
56MP0002282_abnormal_trachea_morphology1.39129951
57MP0003137_abnormal_impulse_conducting1.38649239
58MP0002102_abnormal_ear_morphology1.36798899
59MP0000358_abnormal_cell_content/1.36560748
60MP0004742_abnormal_vestibular_system1.35304796
61MP0000750_abnormal_muscle_regeneration1.33794144
62MP0008932_abnormal_embryonic_tissue1.33772231
63MP0005330_cardiomyopathy1.30690340
64MP0005646_abnormal_pituitary_gland1.30616959
65MP0005332_abnormal_amino_acid1.29717025
66MP0005535_abnormal_body_temperature1.28974027
67MP0001764_abnormal_homeostasis1.27307743
68MP0009046_muscle_twitch1.27298907
69MP0002063_abnormal_learning/memory/cond1.25514184
70MP0000613_abnormal_salivary_gland1.23866725
71MP0002229_neurodegeneration1.23383222
72MP0001486_abnormal_startle_reflex1.22075410
73MP0005408_hypopigmentation1.21907955
74MP0001501_abnormal_sleep_pattern1.21167759
75MP0004019_abnormal_vitamin_homeostasis1.19731847
76MP0001664_abnormal_digestion1.18826535
77MP0009333_abnormal_splenocyte_physiolog1.18276418
78MP0001919_abnormal_reproductive_system1.17221885
79MP0005386_behavior/neurological_phenoty1.16841362
80MP0004924_abnormal_behavior1.16841362
81MP0003011_delayed_dark_adaptation1.16002955
82MP0002751_abnormal_autonomic_nervous1.15794708
83MP0002067_abnormal_sensory_capabilities1.15015064
84MP0004084_abnormal_cardiac_muscle1.14514492
85MP0005645_abnormal_hypothalamus_physiol1.12362582
86MP0001270_distended_abdomen1.11469089
87MP0005423_abnormal_somatic_nervous1.11348811
88MP0001727_abnormal_embryo_implantation1.10519362
89MP0005085_abnormal_gallbladder_physiolo1.09109634
90MP0002160_abnormal_reproductive_system1.08486985
91MP0001873_stomach_inflammation1.07236956
92MP0002693_abnormal_pancreas_physiology1.07025572
93MP0002184_abnormal_innervation1.05388927
94MP0003879_abnormal_hair_cell1.05275109
95MP0001881_abnormal_mammary_gland1.04873028
96MP0005365_abnormal_bile_salt1.04528417
97MP0002909_abnormal_adrenal_gland1.04396745
98MP0009697_abnormal_copulation1.04157082
99MP0005389_reproductive_system_phenotype1.04019077
100MP0000778_abnormal_nervous_system1.03565474
101MP0004381_abnormal_hair_follicle1.03293829
102MP0005409_darkened_coat_color1.03037785
103MP0008995_early_reproductive_senescence1.02450112
104MP0000678_abnormal_parathyroid_gland1.02426500
105MP0005171_absent_coat_pigmentation1.02186364
106MP0005584_abnormal_enzyme/coenzyme_acti1.02140644
107MP0000013_abnormal_adipose_tissue1.00414755
108MP0005367_renal/urinary_system_phenotyp1.00123708
109MP0000516_abnormal_urinary_system1.00123708
110MP0005083_abnormal_biliary_tract0.99872204
111MP0002090_abnormal_vision0.98934705
112MP0001542_abnormal_bone_strength0.98406818
113MP0009643_abnormal_urine_homeostasis0.97322899
114MP0000681_abnormal_thyroid_gland0.96381441
115MP0000015_abnormal_ear_pigmentation0.95595705
116MP0004859_abnormal_synaptic_plasticity0.94537869
117MP0001963_abnormal_hearing_physiology0.93711312
118MP0001756_abnormal_urination0.92999459
119MP0003634_abnormal_glial_cell0.92950020
120MP0001666_abnormal_nutrient_absorption0.91628825
121MP0000538_abnormal_urinary_bladder0.91330349
122MP0008873_increased_physiological_sensi0.90621582
123MP0002066_abnormal_motor_capabilities/c0.90329809
124MP0001485_abnormal_pinna_reflex0.90313420
125MP0003718_maternal_effect0.88928666
126MP0005319_abnormal_enzyme/_coenzyme0.88715551
127MP0005075_abnormal_melanosome_morpholog0.88686336
128MP0009840_abnormal_foam_cell0.87165804
129MP0002557_abnormal_social/conspecific_i0.86628765
130MP0002148_abnormal_hypersensitivity_rea0.86613188
131MP0008007_abnormal_cellular_replicative0.86491570
132MP0008789_abnormal_olfactory_epithelium0.86266082
133MP0001765_abnormal_ion_homeostasis0.86182864
134MP0005084_abnormal_gallbladder_morpholo0.86158867
135MP0002938_white_spotting0.84960521
136MP0006082_CNS_inflammation0.84938852
137MP0000858_altered_metastatic_potential0.82190659
138MP0005410_abnormal_fertilization0.82166015
139MP0006072_abnormal_retinal_apoptosis0.81506097
140MP0001188_hyperpigmentation0.80705999
141MP0008872_abnormal_physiological_respon0.80680550
142MP0001502_abnormal_circadian_rhythm0.79944858
143MP0001944_abnormal_pancreas_morphology0.78846632
144MP0005551_abnormal_eye_electrophysiolog0.78754522
145MP0005671_abnormal_response_to0.77774380
146MP0000955_abnormal_spinal_cord0.77366363
147MP0003638_abnormal_response/metabolism_0.76770730
148MP0002882_abnormal_neuron_morphology0.76753041
149MP0003724_increased_susceptibility_to0.75723192
150MP0000639_abnormal_adrenal_gland0.74302536
151MP0000647_abnormal_sebaceous_gland0.73141797
152MP0003787_abnormal_imprinting0.72679016
153MP0005220_abnormal_exocrine_pancreas0.68577318

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.75735489
2Mitochondrial inheritance (HP:0001427)5.17911979
3Abnormal mitochondria in muscle tissue (HP:0008316)5.14292200
4Acute encephalopathy (HP:0006846)4.91790663
5Progressive macrocephaly (HP:0004481)4.72165070
6Hepatocellular necrosis (HP:0001404)4.56956679
7Increased CSF lactate (HP:0002490)4.38008845
8Hepatic necrosis (HP:0002605)4.16865222
9Renal Fanconi syndrome (HP:0001994)4.10899979
10Increased hepatocellular lipid droplets (HP:0006565)3.98748768
11Lipid accumulation in hepatocytes (HP:0006561)3.64389937
12Cerebral edema (HP:0002181)3.51784742
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.51427310
143-Methylglutaconic aciduria (HP:0003535)3.50102835
15Increased serum pyruvate (HP:0003542)3.49043023
16Abnormality of glycolysis (HP:0004366)3.49043023
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.48453352
18Parakeratosis (HP:0001036)3.42048274
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.36055702
20Leukodystrophy (HP:0002415)3.20954038
21Respiratory failure (HP:0002878)3.18174503
22Lactic acidosis (HP:0003128)3.17136878
23Ependymoma (HP:0002888)3.15875993
24Hypothermia (HP:0002045)3.12731822
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10349012
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10349012
27Increased intramyocellular lipid droplets (HP:0012240)3.03449662
28Abnormality of renal resorption (HP:0011038)3.03120760
29Optic disc pallor (HP:0000543)3.00275859
30Neuroendocrine neoplasm (HP:0100634)2.94289489
31Congenital ichthyosiform erythroderma (HP:0007431)2.92017303
32Astrocytoma (HP:0009592)2.91198788
33Abnormality of the astrocytes (HP:0100707)2.91198788
34Pheochromocytoma (HP:0002666)2.87021795
35Exercise intolerance (HP:0003546)2.81948817
36Increased serum lactate (HP:0002151)2.80839529
37Exertional dyspnea (HP:0002875)2.69760464
38Concave nail (HP:0001598)2.69273699
39Abnormality of aromatic amino acid family metabolism (HP:0004338)2.66273352
40Increased muscle lipid content (HP:0009058)2.61198157
41Myokymia (HP:0002411)2.59446899
42Abnormality of urine glucose concentration (HP:0011016)2.56722191
43Glycosuria (HP:0003076)2.56722191
44Hyperphosphaturia (HP:0003109)2.50733586
45Microretrognathia (HP:0000308)2.49637158
46Vacuolated lymphocytes (HP:0001922)2.44375326
47Cerebral hypomyelination (HP:0006808)2.40756340
48Abnormal protein N-linked glycosylation (HP:0012347)2.37605965
49Abnormal protein glycosylation (HP:0012346)2.37605965
50Abnormal glycosylation (HP:0012345)2.37605965
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37605965
52Neurofibrillary tangles (HP:0002185)2.34131091
53Stomach cancer (HP:0012126)2.31399033
54CNS demyelination (HP:0007305)2.29677072
55X-linked dominant inheritance (HP:0001423)2.28719433
56Degeneration of anterior horn cells (HP:0002398)2.28572449
57Abnormality of the anterior horn cell (HP:0006802)2.28572449
58Lethargy (HP:0001254)2.27739663
59Alveolar cell carcinoma (HP:0006519)2.25323923
60Reduced antithrombin III activity (HP:0001976)2.21552295
61Respiratory difficulties (HP:0002880)2.19207986
62Glioma (HP:0009733)2.18320033
63Congenital malformation of the right heart (HP:0011723)2.15604094
64Double outlet right ventricle (HP:0001719)2.15604094
65Sparse eyelashes (HP:0000653)2.14910907
66Hyperthyroidism (HP:0000836)2.14400517
67Abnormal urine phosphate concentration (HP:0012599)2.13714912
68Limb dystonia (HP:0002451)2.12689039
69Generalized aminoaciduria (HP:0002909)2.12396158
70Methylmalonic aciduria (HP:0012120)2.09700563
71Abnormal pupillary function (HP:0007686)2.09384973
72Petechiae (HP:0000967)2.09081485
73Aplasia/hypoplasia of the uterus (HP:0008684)2.08899633
74Emotional lability (HP:0000712)2.03220751
75Progressive microcephaly (HP:0000253)2.02160398
76Spastic paraparesis (HP:0002313)2.01247452
77Prolonged neonatal jaundice (HP:0006579)1.98953690
78Hypoplasia of the uterus (HP:0000013)1.96223391
79Abnormality of magnesium homeostasis (HP:0004921)1.92462661
80Sensory axonal neuropathy (HP:0003390)1.92300727
81Renal tubular dysfunction (HP:0000124)1.89964443
82Cerebral hemorrhage (HP:0001342)1.89718569
83Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89407817
84Degeneration of the lateral corticospinal tracts (HP:0002314)1.89407817
85Abnormal hair whorl (HP:0010721)1.87885988
86Aplastic anemia (HP:0001915)1.87618303
87Rough bone trabeculation (HP:0100670)1.87578583
88Delusions (HP:0000746)1.87029039
89Medial flaring of the eyebrow (HP:0010747)1.83659322
90Testicular atrophy (HP:0000029)1.83430961
91Tongue fasciculations (HP:0001308)1.83412526
92Abnormal autonomic nervous system physiology (HP:0012332)1.83159716
93Dysautonomia (HP:0002459)1.83025419
94Autoamputation (HP:0001218)1.82874297
95Poor suck (HP:0002033)1.80915686
96Focal motor seizures (HP:0011153)1.79650540
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79267787
98Abnormality of alanine metabolism (HP:0010916)1.79267787
99Hyperalaninemia (HP:0003348)1.79267787
100Hyperventilation (HP:0002883)1.79232229
101Retinal dysplasia (HP:0007973)1.78413791
102Hypomagnesemia (HP:0002917)1.77556595
103Abnormality of dental color (HP:0011073)1.77447829
104Opisthotonus (HP:0002179)1.76693279
105Flat capital femoral epiphysis (HP:0003370)1.74437589
106Pancytopenia (HP:0001876)1.73474328
107Epiphyseal stippling (HP:0010655)1.73445675
108Diminished movement (HP:0002374)1.71363504
109Methylmalonic acidemia (HP:0002912)1.71173339
110Neoplasm of the tracheobronchial system (HP:0100552)1.70546866
111Cerebral inclusion bodies (HP:0100314)1.69021774
112Vomiting (HP:0002013)1.68105969
113Microvesicular hepatic steatosis (HP:0001414)1.67828581
114Brushfield spots (HP:0001088)1.67282534
115Conjugated hyperbilirubinemia (HP:0002908)1.67281001
116Abnormality of dicarboxylic acid metabolism (HP:0010995)1.66834965
117Dicarboxylic aciduria (HP:0003215)1.66834965
118Ketosis (HP:0001946)1.66425387
119Ketoacidosis (HP:0001993)1.66005112
120Abnormal tarsal ossification (HP:0008369)1.65835542
121Amniotic constriction ring (HP:0009775)1.64561157
122Abnormality of placental membranes (HP:0011409)1.64561157
123Gliosis (HP:0002171)1.64155382
124Abnormality of midbrain morphology (HP:0002418)1.63724410
125Molar tooth sign on MRI (HP:0002419)1.63724410
126Blindness (HP:0000618)1.63346965
127Gait imbalance (HP:0002141)1.62210254
128Poor speech (HP:0002465)1.60617011
129CNS hypomyelination (HP:0003429)1.58972166
130Type I transferrin isoform profile (HP:0003642)1.56815475
131Hypokinesia (HP:0002375)1.56777906
132Polyphagia (HP:0002591)1.55240047
133Congenital primary aphakia (HP:0007707)1.53959420
134Nephrogenic diabetes insipidus (HP:0009806)1.53710570
135Split foot (HP:0001839)1.51647439
136Vaginal atresia (HP:0000148)1.51204961
137Muscular hypotonia of the trunk (HP:0008936)1.50895118
138Progressive neurologic deterioration (HP:0002344)1.50117156
139Supranuclear gaze palsy (HP:0000605)1.48903851
140Poor head control (HP:0002421)1.48466751
141Genital tract atresia (HP:0001827)1.48215822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.08078708
2MATK3.75980574
3ARAF3.67059423
4STK162.88018977
5MAP3K122.76985537
6STK392.67505782
7MST42.55023781
8CASK2.53127142
9TLK12.50261654
10OXSR12.36847689
11BCR2.32623612
12NME12.32359592
13WNK42.18727144
14PIM22.01607783
15NME21.81270098
16CDK191.80868136
17LIMK11.79388901
18STK241.76490610
19TRIM281.75169228
20GRK51.74947096
21MAPKAPK31.73457039
22PBK1.71437848
23KDR1.60761688
24MAP4K21.57259931
25EIF2AK31.54703050
26MARK11.54311324
27LMTK21.53148247
28GRK71.51231723
29ILK1.50873073
30DYRK21.49806246
31MYLK1.49662516
32ZAK1.43654920
33ADRBK21.41072900
34BMPR21.40936798
35TNIK1.36937903
36EIF2AK11.36311347
37MST1R1.35966641
38BRAF1.32118977
39WNK31.29298938
40BCKDK1.27269564
41MAP3K21.26719207
42CAMK2B1.26190504
43BUB11.25320846
44CSNK1G31.22253676
45MAPKAPK51.19818227
46NUAK11.18309825
47PNCK1.17007541
48MAP2K71.16650001
49BMPR1B1.16189108
50VRK11.13016355
51GRK11.10918433
52IRAK21.10034137
53MAPK151.09561815
54MUSK1.08781248
55PHKG21.04689995
56PHKG11.04689995
57CAMK2D1.04615266
58CAMK2G1.03320083
59PTK21.02784639
60NTRK11.01122835
61BRSK11.00083931
62IRAK10.99568754
63PINK10.95941647
64PLK20.95763257
65SCYL20.95067853
66UHMK10.94393888
67NEK60.93668658
68TESK10.93123744
69MET0.92935432
70PRKCE0.91645029
71PDK20.91143012
72ERBB30.89025976
73IRAK30.88263105
74NTRK30.87199664
75FRK0.85412443
76CAMK2A0.84103195
77CSNK1G10.81829942
78CSNK1G20.81596758
79LRRK20.79837371
80TESK20.78393418
81FGR0.77947533
82EPHA20.77097983
83TNK20.76968328
84IRAK40.76772687
85MAPK130.74756622
86PKN10.74631210
87SIK30.71025646
88ABL20.70245733
89PAK40.68367219
90AURKA0.67208739
91MINK10.66802314
92PRKCG0.65542288
93CSNK1A1L0.63947962
94EPHB10.63601321
95CDK140.63240288
96MAP3K30.62954934
97MAP2K20.62761147
98AKT30.62273860
99PIK3CA0.61920540
100FER0.61687007
101SRPK10.61256510
102RPS6KA50.60792778
103GRK60.59824060
104ERBB20.54890178
105DAPK30.54505772
106CSNK1A10.54011134
107PRKCI0.52850219
108EPHA40.51490718
109MAP3K110.51260781
110MAP3K130.50867445
111BLK0.50162552
112CDK50.50075643
113MAP2K60.49735556
114KSR20.48936092
115ADRBK10.47865250
116SYK0.46892872
117NEK10.46148203
118CSNK2A10.46133109
119RIPK40.45769923
120PAK10.45545208
121ROCK20.44706689
122CDK180.43819029
123CAMKK20.43747978
124IKBKB0.43609195
125DYRK1A0.43359335
126DAPK10.42319933
127SGK4940.42271213
128SGK2230.42271213
129PRKACA0.42180409
130INSRR0.41856872
131MAP2K10.41093822
132TAOK10.41049742
133TBK10.40974728
134PRKG20.40865216
135PAK30.40842378
136MAP3K90.40380187
137CSNK2A20.39387006
138PRKCQ0.39355019
139STK38L0.39102523
140CDK70.39097124
141CDK150.38174151
142RAF10.38075879
143CDK11A0.37142142
144RPS6KA40.35843368
145PLK10.31136733
146CCNB10.29927523

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.28682394
2Parkinsons disease_Homo sapiens_hsa050124.27574366
3Proteasome_Homo sapiens_hsa030503.78420452
4Protein export_Homo sapiens_hsa030603.67255653
5Alzheimers disease_Homo sapiens_hsa050103.26415446
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.87552695
7Huntingtons disease_Homo sapiens_hsa050162.79418091
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.68126534
9Collecting duct acid secretion_Homo sapiens_hsa049662.67511137
10Sulfur metabolism_Homo sapiens_hsa009202.59028410
11Fatty acid elongation_Homo sapiens_hsa000622.37688042
12Ribosome_Homo sapiens_hsa030102.25209451
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22053729
14Steroid biosynthesis_Homo sapiens_hsa001002.15282048
15Vibrio cholerae infection_Homo sapiens_hsa051101.94299942
16RNA polymerase_Homo sapiens_hsa030201.86338421
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74873544
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.55096824
19Cardiac muscle contraction_Homo sapiens_hsa042601.53359046
20Base excision repair_Homo sapiens_hsa034101.48843729
21Synaptic vesicle cycle_Homo sapiens_hsa047211.46507442
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.41483721
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39226306
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38423563
25Regulation of autophagy_Homo sapiens_hsa041401.36371865
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32273165
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27804397
28Histidine metabolism_Homo sapiens_hsa003401.27754198
29Rheumatoid arthritis_Homo sapiens_hsa053231.26539229
30Caffeine metabolism_Homo sapiens_hsa002321.17716180
31Folate biosynthesis_Homo sapiens_hsa007901.14693254
32Butanoate metabolism_Homo sapiens_hsa006501.13519727
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11658668
34Homologous recombination_Homo sapiens_hsa034401.10776235
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07616959
36Peroxisome_Homo sapiens_hsa041461.02890072
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01814390
38Glutathione metabolism_Homo sapiens_hsa004800.97284045
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96297252
40Phenylalanine metabolism_Homo sapiens_hsa003600.95590452
41Ether lipid metabolism_Homo sapiens_hsa005650.94075676
42Sphingolipid metabolism_Homo sapiens_hsa006000.93066737
43Metabolic pathways_Homo sapiens_hsa011000.92662598
44Pyruvate metabolism_Homo sapiens_hsa006200.92415032
45Tyrosine metabolism_Homo sapiens_hsa003500.90694189
46Nucleotide excision repair_Homo sapiens_hsa034200.89853080
47DNA replication_Homo sapiens_hsa030300.87469820
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87097869
49Arachidonic acid metabolism_Homo sapiens_hsa005900.87018925
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86337745
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85340061
52N-Glycan biosynthesis_Homo sapiens_hsa005100.80854500
53Propanoate metabolism_Homo sapiens_hsa006400.79898423
54Linoleic acid metabolism_Homo sapiens_hsa005910.79839774
55Mismatch repair_Homo sapiens_hsa034300.79537785
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79359429
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78982375
58Phagosome_Homo sapiens_hsa041450.78422801
59Pyrimidine metabolism_Homo sapiens_hsa002400.77745136
60Galactose metabolism_Homo sapiens_hsa000520.77679689
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77131771
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76023914
63Serotonergic synapse_Homo sapiens_hsa047260.74181322
64Chemical carcinogenesis_Homo sapiens_hsa052040.73067600
65Graft-versus-host disease_Homo sapiens_hsa053320.72042075
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.71220855
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71178476
68Vitamin B6 metabolism_Homo sapiens_hsa007500.67648179
69RNA degradation_Homo sapiens_hsa030180.64144357
70Taste transduction_Homo sapiens_hsa047420.63694480
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63049989
72Fanconi anemia pathway_Homo sapiens_hsa034600.62802008
73Arginine and proline metabolism_Homo sapiens_hsa003300.61742751
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61691018
75Other glycan degradation_Homo sapiens_hsa005110.61275927
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61125627
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60892943
78Lysosome_Homo sapiens_hsa041420.59884802
79Phototransduction_Homo sapiens_hsa047440.59654157
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58292639
81Shigellosis_Homo sapiens_hsa051310.55633318
82Autoimmune thyroid disease_Homo sapiens_hsa053200.55288652
83Sulfur relay system_Homo sapiens_hsa041220.54552687
84Nicotine addiction_Homo sapiens_hsa050330.53678915
85GABAergic synapse_Homo sapiens_hsa047270.52559030
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.49743185
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49264259
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48680664
89Pentose phosphate pathway_Homo sapiens_hsa000300.48344616
90Non-homologous end-joining_Homo sapiens_hsa034500.47661110
91One carbon pool by folate_Homo sapiens_hsa006700.47659403
92Type I diabetes mellitus_Homo sapiens_hsa049400.47008730
93Purine metabolism_Homo sapiens_hsa002300.46228007
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45265751
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.44934534
96Primary immunodeficiency_Homo sapiens_hsa053400.44299618
97Allograft rejection_Homo sapiens_hsa053300.44266561
98beta-Alanine metabolism_Homo sapiens_hsa004100.43567123
99Fatty acid degradation_Homo sapiens_hsa000710.43214921
100Fructose and mannose metabolism_Homo sapiens_hsa000510.42541386
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42292835
102RNA transport_Homo sapiens_hsa030130.42049567
103Mineral absorption_Homo sapiens_hsa049780.41071840
104Amphetamine addiction_Homo sapiens_hsa050310.39918558
105Cocaine addiction_Homo sapiens_hsa050300.38635487
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38319502
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.36705928
108Spliceosome_Homo sapiens_hsa030400.36118293
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.34474541
110Biosynthesis of amino acids_Homo sapiens_hsa012300.34415152
111Basal transcription factors_Homo sapiens_hsa030220.33163135
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31562076
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30995624
114Pancreatic secretion_Homo sapiens_hsa049720.30899345
115Selenocompound metabolism_Homo sapiens_hsa004500.30503149
116Tryptophan metabolism_Homo sapiens_hsa003800.30268897
117Retinol metabolism_Homo sapiens_hsa008300.28592422
118Dopaminergic synapse_Homo sapiens_hsa047280.27787290
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27484158
120Fatty acid metabolism_Homo sapiens_hsa012120.27350219
121Insulin secretion_Homo sapiens_hsa049110.27170209
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25331873
123Fat digestion and absorption_Homo sapiens_hsa049750.24826131
124Asthma_Homo sapiens_hsa053100.23389331
125Morphine addiction_Homo sapiens_hsa050320.22758131
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.22411725
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20076699
128Prion diseases_Homo sapiens_hsa050200.19985344
129Carbon metabolism_Homo sapiens_hsa012000.19867455
130Vitamin digestion and absorption_Homo sapiens_hsa049770.18569634

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