MIIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.67733192
2DNA deamination (GO:0045006)4.47609481
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.09240119
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.09240119
5modulation by symbiont of host immune response (GO:0052553)4.09240119
6positive regulation by symbiont of host defense response (GO:0052509)4.09240119
7modulation by symbiont of host defense response (GO:0052031)4.09240119
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.09240119
9regulation of telomere maintenance via telomerase (GO:0032210)3.96524428
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.79143032
11DNA strand elongation involved in DNA replication (GO:0006271)3.77325216
12telomere maintenance via semi-conservative replication (GO:0032201)3.76738994
13neutrophil activation involved in immune response (GO:0002283)3.71534307
14protein localization to kinetochore (GO:0034501)3.66454423
15respiratory burst (GO:0045730)3.63335931
16DNA strand elongation (GO:0022616)3.62357579
17ribosomal large subunit biogenesis (GO:0042273)3.58517742
18response to peptidoglycan (GO:0032494)3.57002805
19immunoglobulin mediated immune response (GO:0016064)3.54641896
20viral transcription (GO:0019083)3.49732153
21negative regulation of erythrocyte differentiation (GO:0045647)3.44175163
22protein localization to chromosome, centromeric region (GO:0071459)3.43706416
23telomere maintenance via recombination (GO:0000722)3.41598540
24translational termination (GO:0006415)3.38134842
25maturation of SSU-rRNA (GO:0030490)3.37835715
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.36553475
27negative regulation of cell killing (GO:0031342)3.36553475
28DNA replication initiation (GO:0006270)3.36222549
29maturation of 5.8S rRNA (GO:0000460)3.30388827
30mitotic sister chromatid segregation (GO:0000070)3.30198388
31NIK/NF-kappaB signaling (GO:0038061)3.28469921
32positive regulation of gamma-delta T cell activation (GO:0046645)3.26514378
33ribosomal small subunit biogenesis (GO:0042274)3.25536489
34negative regulation of myeloid cell apoptotic process (GO:0033033)3.24542011
35mitotic recombination (GO:0006312)3.24300873
36negative regulation of gene silencing (GO:0060969)3.17254014
37kinetochore organization (GO:0051383)3.16130330
38translational elongation (GO:0006414)3.15718510
39negative regulation of B cell apoptotic process (GO:0002903)3.15259999
40negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.12099911
41regulation of mast cell degranulation (GO:0043304)3.11326471
42mitotic metaphase plate congression (GO:0007080)3.09425541
43histone H2A acetylation (GO:0043968)3.09183657
44DNA unwinding involved in DNA replication (GO:0006268)3.08502304
45telomere maintenance via telomere lengthening (GO:0010833)3.03926612
46CENP-A containing nucleosome assembly (GO:0034080)3.03620640
47negative regulation of interleukin-12 production (GO:0032695)3.02966840
48metaphase plate congression (GO:0051310)2.99427848
49protein localization to chromosome (GO:0034502)2.98393281
50regulation of RIG-I signaling pathway (GO:0039535)2.98150371
51kinetochore assembly (GO:0051382)2.95902521
52establishment of chromosome localization (GO:0051303)2.95470750
53meiotic chromosome segregation (GO:0045132)2.95140184
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92431129
55chromatin remodeling at centromere (GO:0031055)2.92172496
56mitotic nuclear envelope disassembly (GO:0007077)2.90910153
57sister chromatid segregation (GO:0000819)2.90710106
58spindle assembly checkpoint (GO:0071173)2.87856640
59somatic hypermutation of immunoglobulin genes (GO:0016446)2.87330638
60somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87330638
61negative regulation of mitotic sister chromatid separation (GO:2000816)2.87158828
62negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87158828
63negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87158828
64negative regulation of sister chromatid segregation (GO:0033046)2.87158828
65detection of bacterium (GO:0016045)2.86779647
66negative regulation of chromosome segregation (GO:0051985)2.86484664
67ribonucleoprotein complex biogenesis (GO:0022613)2.86241832
68formation of translation preinitiation complex (GO:0001731)2.85637138
69mitotic spindle assembly checkpoint (GO:0007094)2.85523324
70metallo-sulfur cluster assembly (GO:0031163)2.83869011
71iron-sulfur cluster assembly (GO:0016226)2.83869011
72regulation of superoxide anion generation (GO:0032928)2.83824086
73regulation of gamma-delta T cell activation (GO:0046643)2.83122160
74translational initiation (GO:0006413)2.82758157
75pentose metabolic process (GO:0019321)2.82050517
76Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81804742
77nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81627151
78mitotic chromosome condensation (GO:0007076)2.81066289
79regulation of spindle organization (GO:0090224)2.80260422
80regulation of myeloid leukocyte mediated immunity (GO:0002886)2.79844702
81rRNA modification (GO:0000154)2.79528911
82peptidyl-arginine omega-N-methylation (GO:0035247)2.79443296
83negative regulation of DNA-templated transcription, elongation (GO:0032785)2.79093530
84regulation of mitochondrial translation (GO:0070129)2.78426931
85response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77346049
86response to host immune response (GO:0052572)2.77346049
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76821220
88positive regulation of B cell differentiation (GO:0045579)2.76736648
89negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76473916
90detection of other organism (GO:0098543)2.76011425
91UV protection (GO:0009650)2.75400030
92purine deoxyribonucleotide catabolic process (GO:0009155)2.75122466
93protein insertion into membrane (GO:0051205)2.74690908
94response to muramyl dipeptide (GO:0032495)2.73200965
95SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.72909438
96leukocyte aggregation (GO:0070486)2.72729201
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.71807003
98nucleotide-excision repair, DNA gap filling (GO:0006297)2.70295409
99negative regulation of RNA splicing (GO:0033119)2.69568276
100anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68856057
101cellular protein complex disassembly (GO:0043624)2.68643098
102B cell mediated immunity (GO:0019724)2.68015378
103DNA replication-independent nucleosome assembly (GO:0006336)2.67831247
104DNA replication-independent nucleosome organization (GO:0034724)2.67831247
105regulation of mast cell activation involved in immune response (GO:0033006)2.66457201
106snRNA metabolic process (GO:0016073)2.65909253
107attachment of spindle microtubules to kinetochore (GO:0008608)2.65874754
108rRNA processing (GO:0006364)2.65814242
109viral mRNA export from host cell nucleus (GO:0046784)2.65270180
110spindle checkpoint (GO:0031577)2.64455503
111viral life cycle (GO:0019058)2.64424885
112cotranslational protein targeting to membrane (GO:0006613)2.64393013
113regulation of chromatin silencing (GO:0031935)2.63743853
114regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.62842220
115regulation of chromosome segregation (GO:0051983)2.62812321
116macrophage activation involved in immune response (GO:0002281)2.62803986
117snRNA processing (GO:0016180)2.62281558
118DNA replication checkpoint (GO:0000076)2.62093373
119regulation of interferon-beta biosynthetic process (GO:0045357)2.61315023
120telomere organization (GO:0032200)2.61199026
121antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.61103201
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61103201
123negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.61065252
124telomere maintenance (GO:0000723)2.60893004
125pentose-phosphate shunt (GO:0006098)2.60764478
126protein targeting to ER (GO:0045047)2.59979109
127regulation of leukocyte degranulation (GO:0043300)2.59740766
128rRNA metabolic process (GO:0016072)2.58629728
129negative regulation of phagocytosis (GO:0050765)2.58063638
130histone arginine methylation (GO:0034969)2.57570461
131nucleobase biosynthetic process (GO:0046112)2.57201312
132nuclear envelope disassembly (GO:0051081)2.57184925
133membrane disassembly (GO:0030397)2.57184925
134mannose metabolic process (GO:0006013)2.56519995
135mitotic spindle checkpoint (GO:0071174)2.56073202
136mismatch repair (GO:0006298)2.54892549
137ncRNA 3-end processing (GO:0043628)2.54777971
138protein complex disassembly (GO:0043241)2.54636140
139regulation of B cell apoptotic process (GO:0002902)2.54037216
140regulation of mitotic metaphase/anaphase transition (GO:0030071)2.54027263
141modulation by virus of host process (GO:0019054)2.53230290
142pyrimidine-containing compound salvage (GO:0008655)2.52552128
143pyrimidine nucleoside salvage (GO:0043097)2.52552128
144regulation of nuclear cell cycle DNA replication (GO:0033262)2.52465535
145ribosome biogenesis (GO:0042254)2.52046930
146mitochondrial fusion (GO:0008053)2.51910185
147regulation of mitotic sister chromatid segregation (GO:0033047)2.51835901
148regulation of sister chromatid segregation (GO:0033045)2.51835901
149regulation of mitotic sister chromatid separation (GO:0010965)2.51835901
150regulation of gamma-delta T cell differentiation (GO:0045586)2.51189707
151positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.50393512
152regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.50320760
1533-UTR-mediated mRNA stabilization (GO:0070935)2.49975444
154granulocyte differentiation (GO:0030851)2.49399272
155oxidative phosphorylation (GO:0006119)2.49343801
156pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.49188873
157GDP-mannose metabolic process (GO:0019673)2.48120876
158antigen processing and presentation of endogenous antigen (GO:0019883)2.48055218
159leukocyte degranulation (GO:0043299)2.47779387
160amino sugar catabolic process (GO:0046348)2.46736690
161positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.46702871
162regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.46523729
163negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.46269669
164reactive oxygen species biosynthetic process (GO:1903409)2.45974566
165positive regulation of gene expression, epigenetic (GO:0045815)2.45835396
166protein localization to endoplasmic reticulum (GO:0070972)2.45590613
167myeloid cell activation involved in immune response (GO:0002275)2.45492045
168regulation of B cell differentiation (GO:0045577)2.45450276
169positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.45163779
170chaperone mediated protein folding requiring cofactor (GO:0051085)2.42538844
171deoxyribonucleotide catabolic process (GO:0009264)2.40302232
172NADPH regeneration (GO:0006740)2.39760274
173negative regulation of innate immune response (GO:0045824)2.38323980
174heme biosynthetic process (GO:0006783)2.34908800
175neutrophil activation (GO:0042119)2.34573694
176mitochondrion transport along microtubule (GO:0047497)2.34252911
177establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.34252911
178response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.33547639
179response to host (GO:0075136)2.33547639
180response to host defenses (GO:0052200)2.33547639
181defense response to protozoan (GO:0042832)2.33533334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.45376589
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.33751418
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34196386
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17457400
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.17411675
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05012644
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70265035
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49983508
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.49684588
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43942935
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42534419
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40264736
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38820307
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.38633268
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33912489
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31793780
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27508562
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.27002736
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20499043
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18878521
21MYC_22102868_ChIP-Seq_BL_Human2.15567921
22VDR_23849224_ChIP-Seq_CD4+_Human2.13893986
23CIITA_25753668_ChIP-Seq_RAJI_Human2.07540433
24LXR_22292898_ChIP-Seq_THP-1_Human2.05691242
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03559225
26FOXP3_21729870_ChIP-Seq_TREG_Human2.02986785
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.98919835
28VDR_21846776_ChIP-Seq_THP-1_Human1.98490017
29XRN2_22483619_ChIP-Seq_HELA_Human1.98308594
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94881463
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94289678
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84022553
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.82929900
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80343287
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78982399
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78478758
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.77214899
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74048640
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70952642
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70404035
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67085603
42SCL_19346495_ChIP-Seq_HPC-7_Human1.66168110
43* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64635189
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.64462266
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.63708084
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63275496
47P68_20966046_ChIP-Seq_HELA_Human1.63234148
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62395120
49GABP_19822575_ChIP-Seq_HepG2_Human1.59903839
50DCP1A_22483619_ChIP-Seq_HELA_Human1.59857120
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59821134
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.59256636
53SPI1_23547873_ChIP-Seq_NB4_Human1.58765370
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57693346
55* TET1_21451524_ChIP-Seq_MESCs_Mouse1.55496477
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.55387113
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54367805
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.54251045
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52988485
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.51032488
61* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50447374
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.50383461
63* KDM2B_26808549_Chip-Seq_DND41_Human1.49415391
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.49155600
65BCL6_27268052_Chip-Seq_Bcells_Human1.48508007
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44593008
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44104533
68TTF2_22483619_ChIP-Seq_HELA_Human1.44086440
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42265665
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41386219
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41355942
72* SA1_27219007_Chip-Seq_ERYTHROID_Human1.40803965
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39713989
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39104952
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36237584
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35497232
77AR_21909140_ChIP-Seq_LNCAP_Human1.34399102
78BCOR_27268052_Chip-Seq_Bcells_Human1.34364285
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34136064
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33246004
81MYB_26560356_Chip-Seq_TH2_Human1.32510548
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29936211
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28897596
84NCOR1_26117541_ChIP-Seq_K562_Human1.28274664
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27726817
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27400462
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27255171
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24986268
89KDM5A_27292631_Chip-Seq_BREAST_Human1.24603662
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24322241
91PHF8_20622854_ChIP-Seq_HELA_Human1.24127936
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23762563
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.23474709
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23128915
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.22820185
96* MYB_26560356_Chip-Seq_TH1_Human1.21789857
97* MAF_26560356_Chip-Seq_TH1_Human1.21650783
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18268737
99* UTX_26944678_Chip-Seq_JUKART_Human1.17987990
100* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17914475
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17512088
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16891148
103* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15802470
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14956801
105STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14847527
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14697515
107* RACK7_27058665_Chip-Seq_MCF-7_Human1.14688630
108RUNX1_22412390_ChIP-Seq_EML_Mouse1.14376396
109FOXP1_21924763_ChIP-Seq_HESCs_Human1.14270716
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13968614
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13589196
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12558123
113* SA1_27219007_Chip-Seq_Bcells_Human1.11821607
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10519811
115YY1_22570637_ChIP-Seq_MALME-3M_Human1.10439078
116ELK1_19687146_ChIP-ChIP_HELA_Human1.09161346
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08813445
118GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08642004
119ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08495745
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06980510
121VDR_24763502_ChIP-Seq_THP-1_Human1.04504747
122CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04161865
123* MAF_26560356_Chip-Seq_TH2_Human1.03468907
124BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03468518
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01753115
126PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00797561
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96871779
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95342933
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93639758
130TCF7_22412390_ChIP-Seq_EML_Mouse0.93306363
131FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91769433
132PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88878218
133CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88741797
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87818457
135* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87490414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.77782661
2MP0003111_abnormal_nucleus_morphology3.74089552
3MP0002396_abnormal_hematopoietic_system3.71851027
4MP0010094_abnormal_chromosome_stability3.24831598
5MP0003077_abnormal_cell_cycle3.05993756
6MP0008058_abnormal_DNA_repair3.05310705
7MP0005058_abnormal_lysosome_morphology3.01763767
8MP0001835_abnormal_antigen_presentation2.91952551
9MP0008057_abnormal_DNA_replication2.70807171
10MP0000685_abnormal_immune_system2.59507360
11MP0004957_abnormal_blastocyst_morpholog2.52455340
12MP0005671_abnormal_response_to2.36657921
13MP0003763_abnormal_thymus_physiology2.35691657
14MP0003303_peritoneal_inflammation2.35357829
15MP0005397_hematopoietic_system_phenotyp2.34163675
16MP0001545_abnormal_hematopoietic_system2.34163675
17MP0008007_abnormal_cellular_replicative2.27779630
18MP0001800_abnormal_humoral_immune2.12807247
19MP0009278_abnormal_bone_marrow2.12744513
20MP0002398_abnormal_bone_marrow2.08277411
21MP0004147_increased_porphyrin_level2.05434492
22MP0005451_abnormal_body_composition2.02720913
23MP0000465_gastrointestinal_hemorrhage1.89111551
24MP0009785_altered_susceptibility_to1.85432975
25MP0001873_stomach_inflammation1.85276710
26MP0000689_abnormal_spleen_morphology1.84483173
27MP0002452_abnormal_antigen_presenting1.83937046
28MP0002420_abnormal_adaptive_immunity1.82823651
29MP0003172_abnormal_lysosome_physiology1.82729982
30MP0003786_premature_aging1.82008163
31MP0002722_abnormal_immune_system1.80986290
32MP0001819_abnormal_immune_cell1.80663564
33MP0004808_abnormal_hematopoietic_stem1.80523449
34MP0000490_abnormal_crypts_of1.79606382
35MP0003436_decreased_susceptibility_to1.79373368
36MP0002723_abnormal_immune_serum1.79185239
37MP0000716_abnormal_immune_system1.73563321
38MP0009333_abnormal_splenocyte_physiolog1.72599268
39MP0005025_abnormal_response_to1.72566975
40MP0000703_abnormal_thymus_morphology1.68361189
41MP0006035_abnormal_mitochondrial_morpho1.65697567
42MP0005000_abnormal_immune_tolerance1.64157090
43MP0002429_abnormal_blood_cell1.62250288
44MP0000015_abnormal_ear_pigmentation1.61553630
45MP0009840_abnormal_foam_cell1.60735749
46MP0009379_abnormal_foot_pigmentation1.60631277
47MP0010352_gastrointestinal_tract_polyps1.60140281
48MP0006292_abnormal_olfactory_placode1.59901644
49MP0002132_abnormal_respiratory_system1.59600239
50MP0005387_immune_system_phenotype1.55831349
51MP0001790_abnormal_immune_system1.55831349
52MP0006036_abnormal_mitochondrial_physio1.55584522
53MP0005464_abnormal_platelet_physiology1.50561827
54MP0006082_CNS_inflammation1.49974075
55MP0002095_abnormal_skin_pigmentation1.49385871
56MP0002019_abnormal_tumor_incidence1.48887291
57MP0001853_heart_inflammation1.45558285
58MP0005075_abnormal_melanosome_morpholog1.45067990
59MP0002419_abnormal_innate_immunity1.41657847
60MP0008877_abnormal_DNA_methylation1.40335479
61MP0002653_abnormal_ependyma_morphology1.35762828
62MP0008995_early_reproductive_senescence1.34122210
63MP0000350_abnormal_cell_proliferation1.30758477
64MP0005174_abnormal_tail_pigmentation1.30324348
65MP0000313_abnormal_cell_death1.28348406
66MP0002405_respiratory_system_inflammati1.27964292
67MP0001730_embryonic_growth_arrest1.26362769
68MP0001533_abnormal_skeleton_physiology1.25829922
69MP0002148_abnormal_hypersensitivity_rea1.25747628
70MP0010155_abnormal_intestine_physiology1.22089738
71MP0002166_altered_tumor_susceptibility1.20357754
72MP0008932_abnormal_embryonic_tissue1.17570582
73MP0003191_abnormal_cellular_cholesterol1.11748303
74MP0003787_abnormal_imprinting1.09447519
75MP0001845_abnormal_inflammatory_respons1.08702163
76MP0003866_abnormal_defecation1.08532735
77MP0009764_decreased_sensitivity_to1.08214752
78MP0002006_tumorigenesis1.07401216
79MP0003806_abnormal_nucleotide_metabolis1.06645978
80MP0003724_increased_susceptibility_to1.06498507
81MP0000343_altered_response_to1.04456284
82MP0005083_abnormal_biliary_tract1.03564850
83MP0000858_altered_metastatic_potential1.02427135
84MP0002210_abnormal_sex_determination1.01814818
85MP0004381_abnormal_hair_follicle1.00077053
86MP0003136_yellow_coat_color0.97989828
87MP0000371_diluted_coat_color0.96164442
88MP0003656_abnormal_erythrocyte_physiolo0.95569020
89MP0000358_abnormal_cell_content/0.94846061
90MP0001849_ear_inflammation0.94749532
91MP0001929_abnormal_gametogenesis0.92286403
92MP0000604_amyloidosis0.91911843
93MP0000678_abnormal_parathyroid_gland0.89811881
94MP0001986_abnormal_taste_sensitivity0.87855664
95MP0010307_abnormal_tumor_latency0.87104049
96MP0004185_abnormal_adipocyte_glucose0.86092999
97MP0001764_abnormal_homeostasis0.84830884
98MP0002080_prenatal_lethality0.84787532
99MP0003646_muscle_fatigue0.84778350
100MP0001145_abnormal_male_reproductive0.83991569
101MP0008469_abnormal_protein_level0.81437415
102MP0002160_abnormal_reproductive_system0.80536879
103MP0003123_paternal_imprinting0.80470806
104MP0008260_abnormal_autophagy0.80137639
105MP0005380_embryogenesis_phenotype0.79310485
106MP0001672_abnormal_embryogenesis/_devel0.79310485
107MP0003329_amyloid_beta_deposits0.77523543
108MP0005310_abnormal_salivary_gland0.76079445
109MP0002254_reproductive_system_inflammat0.74147017
110MP0004858_abnormal_nervous_system0.73105705
111MP0002075_abnormal_coat/hair_pigmentati0.72897858
112MP0004947_skin_inflammation0.72034763
113MP0003075_altered_response_to0.71770832
114MP0003984_embryonic_growth_retardation0.69983456
115MP0005410_abnormal_fertilization0.69730767
116MP0000747_muscle_weakness0.69709760
117MP0001697_abnormal_embryo_size0.68913041
118MP0005394_taste/olfaction_phenotype0.68878715
119MP0005499_abnormal_olfactory_system0.68878715
120MP0001661_extended_life_span0.68577388
121MP0000653_abnormal_sex_gland0.68142493
122MP0005584_abnormal_enzyme/coenzyme_acti0.67088276
123MP0001663_abnormal_digestive_system0.65910188
124MP0002088_abnormal_embryonic_growth/wei0.65746556
125MP0001119_abnormal_female_reproductive0.64600575
126MP0002086_abnormal_extraembryonic_tissu0.64312985
127MP0005389_reproductive_system_phenotype0.63890293
128MP0001188_hyperpigmentation0.62819725
129MP0003300_gastrointestinal_ulcer0.62434890
130MP0000477_abnormal_intestine_morphology0.60399440
131MP0005377_hearing/vestibular/ear_phenot0.60392511
132MP0003878_abnormal_ear_physiology0.60392511
133MP0003186_abnormal_redox_activity0.58210223
134MP0003718_maternal_effect0.57016871

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)3.94371359
2Abnormality of macrophages (HP:0004311)3.94276422
3Abnormality of cells of the erythroid lineage (HP:0012130)3.88425330
4Abnormal number of erythroid precursors (HP:0012131)3.88287557
5Colon cancer (HP:0003003)3.77383112
6Reticulocytopenia (HP:0001896)3.69984371
7Thrombocytosis (HP:0001894)3.46382040
8Myositis (HP:0100614)3.38539387
9Entropion (HP:0000621)3.37165564
10Abnormality of reticulocytes (HP:0004312)3.31652093
11Elevated erythrocyte sedimentation rate (HP:0003565)3.28107670
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15125667
13Chromsome breakage (HP:0040012)3.13830169
14Chronic otitis media (HP:0000389)3.12361594
15Panhypogammaglobulinemia (HP:0003139)3.12277805
16Hypertensive crisis (HP:0100735)3.10437794
17Reticulocytosis (HP:0001923)3.08755726
18Increased cerebral lipofuscin (HP:0011813)3.03649364
19IgM deficiency (HP:0002850)3.01806477
20Microvesicular hepatic steatosis (HP:0001414)2.93874132
21Increased neuronal autofluorescent lipopigment (HP:0002074)2.83638496
22Increased serum ferritin (HP:0003281)2.80411729
23Recurrent viral infections (HP:0004429)2.79619261
24Recurrent abscess formation (HP:0002722)2.77659000
25Medulloblastoma (HP:0002885)2.76334051
26Petechiae (HP:0000967)2.75100725
27Recurrent gram-negative bacterial infections (HP:0005420)2.72642017
28Recurrent bronchitis (HP:0002837)2.71143279
29Cerebellar dysplasia (HP:0007033)2.66219624
30Myelodysplasia (HP:0002863)2.65066140
31Ragged-red muscle fibers (HP:0003200)2.64701694
32Birth length less than 3rd percentile (HP:0003561)2.61815827
33Nasal polyposis (HP:0100582)2.61349507
34Abnormal gallbladder physiology (HP:0012438)2.54932953
35Cholecystitis (HP:0001082)2.54932953
36Recurrent fungal infections (HP:0002841)2.53473635
37Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.52678793
38Stomatitis (HP:0010280)2.51731520
39Type I transferrin isoform profile (HP:0003642)2.50513591
40Abnormality of B cell number (HP:0010975)2.50241587
41B lymphocytopenia (HP:0010976)2.50241587
42Recurrent bacterial skin infections (HP:0005406)2.50190685
43Truncus arteriosus (HP:0001660)2.49451715
44Oral leukoplakia (HP:0002745)2.47801779
45Meningitis (HP:0001287)2.47357615
46Hepatocellular necrosis (HP:0001404)2.45825197
47Agnosia (HP:0010524)2.44460445
48Pallor (HP:0000980)2.44237730
49Hepatosplenomegaly (HP:0001433)2.43759719
50Agammaglobulinemia (HP:0004432)2.43267044
51IgG deficiency (HP:0004315)2.42824827
52Cutaneous photosensitivity (HP:0000992)2.42441852
53Abnormality of T cells (HP:0002843)2.41522358
54Granulocytopenia (HP:0001913)2.41018984
55Increased IgE level (HP:0003212)2.40187877
56Pancytopenia (HP:0001876)2.40073313
57Bone marrow hypocellularity (HP:0005528)2.38625366
58Optic neuritis (HP:0100653)2.37794568
59Retrobulbar optic neuritis (HP:0100654)2.37794568
60Abnormality of T cell physiology (HP:0011840)2.37155066
61Abnormality of the nasal mucosa (HP:0000433)2.35210840
62Lymphoma (HP:0002665)2.34874722
63Increased IgM level (HP:0003496)2.34785396
64Orchitis (HP:0100796)2.33129668
65Optic nerve coloboma (HP:0000588)2.31845884
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31790437
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31790437
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.30719976
69Urticaria (HP:0001025)2.30716275
70Abnormality of DNA repair (HP:0003254)2.30213206
71Aplasia/Hypoplasia of the thymus (HP:0010515)2.29198293
72Encephalitis (HP:0002383)2.28580852
73Basal cell carcinoma (HP:0002671)2.28562002
74Seborrheic dermatitis (HP:0001051)2.27751818
75Abnormality of the preputium (HP:0100587)2.27085465
76Deep palmar crease (HP:0006191)2.24277461
77Abnormality of the heme biosynthetic pathway (HP:0010472)2.24212770
78Selective tooth agenesis (HP:0001592)2.24203914
79Lymphopenia (HP:0001888)2.23476581
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.22245688
81Combined immunodeficiency (HP:0005387)2.21538915
82Clubbing of toes (HP:0100760)2.20168646
83Amaurosis fugax (HP:0100576)2.19348943
84Recurrent sinusitis (HP:0011108)2.15386994
85Abnormal mitochondria in muscle tissue (HP:0008316)2.14599831
86Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14435317
87Severe combined immunodeficiency (HP:0004430)2.13444608
88Vacuolated lymphocytes (HP:0001922)2.12206905
89Abnormality of chromosome stability (HP:0003220)2.12055025
90Breast hypoplasia (HP:0003187)2.11770526
91Cellular immunodeficiency (HP:0005374)2.10997433
92Recurrent skin infections (HP:0001581)2.10644272
9311 pairs of ribs (HP:0000878)2.10276963
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.09647823
95Leukopenia (HP:0001882)2.09614417
96Hypochromic anemia (HP:0001931)2.08415240
97Abnormality of iron homeostasis (HP:0011031)2.07592520
98Mediastinal lymphadenopathy (HP:0100721)2.06216689
99Meckel diverticulum (HP:0002245)2.05716307
100Pustule (HP:0200039)2.05637803
101Abnormality of the ileum (HP:0001549)2.05539494
102Stomach cancer (HP:0012126)2.04743111
103Abnormality of the fingertips (HP:0001211)2.04731705
104Patellar aplasia (HP:0006443)2.04399622
105Poikiloderma (HP:0001029)2.03993949
106Multiple enchondromatosis (HP:0005701)2.03355531
107Rough bone trabeculation (HP:0100670)2.03200938
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01706700
109Prolonged bleeding time (HP:0003010)2.00999711
110Cellulitis (HP:0100658)2.00829522
111Hyperthyroidism (HP:0000836)2.00536340
112Severe visual impairment (HP:0001141)1.98870177
113Thoracic kyphosis (HP:0002942)1.98867938
114Neoplasm of the adrenal cortex (HP:0100641)1.98437599
115Abnormality of glycolipid metabolism (HP:0010969)1.98433580
116Abnormality of liposaccharide metabolism (HP:0010968)1.98433580
117Abnormality of glycosphingolipid metabolism (HP:0004343)1.98433580
118T lymphocytopenia (HP:0005403)1.97853864
119Centrally nucleated skeletal muscle fibers (HP:0003687)1.97707073
120Inflammation of the large intestine (HP:0002037)1.97588541
121Macrocytic anemia (HP:0001972)1.97307388
122Myopathic facies (HP:0002058)1.97090331
123Mitochondrial inheritance (HP:0001427)1.97014117
124Reduced antithrombin III activity (HP:0001976)1.95494379
125Chest pain (HP:0100749)1.95235916
126Colitis (HP:0002583)1.94998122
127Premature graying of hair (HP:0002216)1.94840994
128Chronic obstructive pulmonary disease (HP:0006510)1.94621298
129Obstructive lung disease (HP:0006536)1.94621298
130Retinal atrophy (HP:0001105)1.94592383
131Gastrointestinal inflammation (HP:0004386)1.94567033
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.93396731
133Ectopic kidney (HP:0000086)1.92035534
134Eczematoid dermatitis (HP:0000976)1.91858466
135Abnormality of T cell number (HP:0011839)1.91093146
136Horseshoe kidney (HP:0000085)1.91081357
137Increased CSF lactate (HP:0002490)1.90653846
138Acute necrotizing encephalopathy (HP:0006965)1.90605728
139Microretrognathia (HP:0000308)1.89842841
140Sepsis (HP:0100806)1.88992326
141Abnormality of the prostate (HP:0008775)1.88936212
142Eosinophilia (HP:0001880)1.88751170
143Loss of speech (HP:0002371)1.87420621
144Neutropenia (HP:0001875)1.87300914
145Abnormality of the renal collecting system (HP:0004742)1.86627771
146Anomalous pulmonary venous return (HP:0010772)1.86610044
147Tented upper lip vermilion (HP:0010804)1.86177383
148Abnormal spermatogenesis (HP:0008669)1.85563596
149Gastrointestinal stroma tumor (HP:0100723)1.85239817
150Aplasia/Hypoplasia of the patella (HP:0006498)1.85205219
151Epistaxis (HP:0000421)1.84702580
152Abnormality of eosinophils (HP:0001879)1.84362225
153Premature loss of primary teeth (HP:0006323)1.84139407
154Respiratory difficulties (HP:0002880)1.83951433
155Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83320913
156Purpura (HP:0000979)1.82358270
157Gastrointestinal infarctions (HP:0005244)1.81392514
158Polycythemia (HP:0001901)1.80570248
159Broad distal phalanx of finger (HP:0009836)1.80262073
160Hepatic necrosis (HP:0002605)1.79106361
161Cerebral palsy (HP:0100021)1.76251354
162Progressive muscle weakness (HP:0003323)1.75554001
163Progressive external ophthalmoplegia (HP:0000590)1.73416146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.57171795
2WEE13.31662929
3MAP3K113.09720179
4MAP4K13.02034752
5RIPK42.66412295
6NEK22.63302973
7EEF2K2.47847441
8STK162.18475254
9EIF2AK12.07718555
10CDK192.03305848
11TSSK61.99238150
12TNK21.95495954
13PRPF4B1.91506034
14STK101.90918614
15PDK21.89866570
16CDC71.83929448
17SMG11.74093968
18BTK1.73101793
19TRIB31.72191499
20IRAK41.66108995
21TXK1.64057575
22RPS6KB21.64055792
23BRSK21.54041141
24TBK11.53578012
25SRPK11.52854511
26KIT1.52259006
27NME21.50802789
28ZAP701.50514726
29IKBKE1.50109687
30ATR1.49707335
31TEC1.48241182
32PLK11.44211981
33TYK21.43805190
34TTK1.42103285
35TLK11.41410979
36MAP3K101.40669974
37MAP2K31.40511171
38BLK1.40009363
39BCKDK1.36202701
40VRK21.35222500
41VRK11.34509891
42GRK61.31963634
43CDK71.31781672
44EIF2AK31.29462333
45PASK1.27443378
46CCNB11.27376770
47CSF1R1.26263235
48CDK41.25864536
49BRSK11.24141141
50CLK11.23984478
51TAOK21.23335290
52TESK11.22503325
53MARK21.21519450
54NME11.20309311
55STK41.18070035
56AURKB1.17354088
57ARAF1.17279613
58FLT31.17036564
59DYRK31.16255135
60RPS6KA41.16131422
61FES1.15672892
62IKBKB1.14828501
63MAP3K81.12100341
64TAOK11.11767024
65RAF11.08614855
66PLK41.07785975
67IRAK31.06983795
68PIM21.06940803
69PIM11.05211737
70ZAK1.04605298
71SIK21.04233953
72BRAF1.03930786
73SYK0.99794184
74JAK30.98229167
75ICK0.97063436
76BMX0.91506392
77NEK10.90228444
78SIK10.89989001
79ITK0.88687465
80PAK40.88428030
81FGR0.88289672
82CDK120.87993569
83MAPKAPK30.87683717
84MATK0.87560869
85ACVR1B0.86203672
86CHEK20.85929666
87LYN0.84518936
88TGFBR10.82861625
89MAP3K10.79602214
90CHEK10.78968029
91LRRK20.78328654
92TNIK0.75893273
93MAP2K60.73687797
94TAOK30.72034430
95AURKA0.71985779
96DMPK0.71519236
97PAK10.71517541
98MKNK10.71066830
99NLK0.70922731
100DYRK20.70733553
101LCK0.70561658
102EIF2AK20.69954540
103ERN10.68216301
104MAP2K20.66838654
105EPHA20.66475190
106TESK20.65821826
107MAP3K140.65638624
108KDR0.63326049
109MARK30.62439273
110MAP4K20.58047606
111MAPK120.56873266
112HCK0.55785199
113JAK20.55169462
114RPS6KL10.55105518
115RPS6KC10.55105518
116CHUK0.54425275
117ABL20.53959551
118RPS6KA60.53239670
119PLK30.53158343
120MKNK20.52172133
121PTK60.50671326
122MAPK110.50176525
123PDPK10.50137112
124CSK0.48693963
125YES10.47608995
126SCYL20.47192816
127MAPKAPK20.45948894
128ATM0.44088405
129CSNK1G30.44079138
130CSNK2A10.43875737
131RPS6KA10.43308945
132RPS6KA50.43113554
133CDK20.43029995
134RPS6KB10.41699096
135EPHB10.41386221
136PDK10.41293029
137MAP3K30.40914603
138MAP3K60.40369796
139PRKCQ0.40322518
140ILK0.39763595
141ALK0.39002632
142SIK30.38731602
143CSNK1A1L0.37675828
144PRKD20.36028206
145FGFR40.34286628
146PRKCI0.31066796
147DYRK1B0.30647807

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.24747872
2Mismatch repair_Homo sapiens_hsa034303.67229362
3Base excision repair_Homo sapiens_hsa034103.35408581
4Ribosome_Homo sapiens_hsa030103.32280992
5Spliceosome_Homo sapiens_hsa030402.85100961
6Homologous recombination_Homo sapiens_hsa034402.78642936
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.52678268
8Primary immunodeficiency_Homo sapiens_hsa053402.50251915
9Proteasome_Homo sapiens_hsa030502.41857679
10RNA polymerase_Homo sapiens_hsa030202.38606676
11RNA transport_Homo sapiens_hsa030132.26990149
12Nucleotide excision repair_Homo sapiens_hsa034202.21596138
13Pyrimidine metabolism_Homo sapiens_hsa002402.14122695
14Fanconi anemia pathway_Homo sapiens_hsa034602.10256428
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07604017
16Cell cycle_Homo sapiens_hsa041102.07204389
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05556341
18Non-homologous end-joining_Homo sapiens_hsa034502.00790214
19One carbon pool by folate_Homo sapiens_hsa006702.00202506
20Herpes simplex infection_Homo sapiens_hsa051681.63909027
21Parkinsons disease_Homo sapiens_hsa050121.52241756
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50155810
23p53 signaling pathway_Homo sapiens_hsa041151.46713215
24Measles_Homo sapiens_hsa051621.46696186
25RNA degradation_Homo sapiens_hsa030181.44535989
26Basal transcription factors_Homo sapiens_hsa030221.43044854
27Antigen processing and presentation_Homo sapiens_hsa046121.42866075
28Staphylococcus aureus infection_Homo sapiens_hsa051501.38233689
29Selenocompound metabolism_Homo sapiens_hsa004501.37121207
30Oxidative phosphorylation_Homo sapiens_hsa001901.36690585
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.28257236
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25720163
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.22658178
34Purine metabolism_Homo sapiens_hsa002301.21638613
35Epstein-Barr virus infection_Homo sapiens_hsa051691.18654213
36mRNA surveillance pathway_Homo sapiens_hsa030151.14554491
37Pentose phosphate pathway_Homo sapiens_hsa000301.13558261
38Salmonella infection_Homo sapiens_hsa051321.12223588
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10662050
40Lysosome_Homo sapiens_hsa041421.09278991
41Hematopoietic cell lineage_Homo sapiens_hsa046401.05575075
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03306082
43Phagosome_Homo sapiens_hsa041451.02128237
44Influenza A_Homo sapiens_hsa051641.01609677
45Leishmaniasis_Homo sapiens_hsa051401.01035344
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98694187
47Legionellosis_Homo sapiens_hsa051340.95953291
48Systemic lupus erythematosus_Homo sapiens_hsa053220.95794044
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95334934
50B cell receptor signaling pathway_Homo sapiens_hsa046620.93800462
51Viral carcinogenesis_Homo sapiens_hsa052030.91383495
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.86684919
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.86114018
54Huntingtons disease_Homo sapiens_hsa050160.85378825
55Rheumatoid arthritis_Homo sapiens_hsa053230.85230638
56Other glycan degradation_Homo sapiens_hsa005110.82821442
57Malaria_Homo sapiens_hsa051440.81904339
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81327429
59Vitamin B6 metabolism_Homo sapiens_hsa007500.80765028
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.79622450
61Fructose and mannose metabolism_Homo sapiens_hsa000510.79306172
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79267695
63VEGF signaling pathway_Homo sapiens_hsa043700.78344375
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76673401
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76261463
66Allograft rejection_Homo sapiens_hsa053300.76107979
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75934638
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75608032
69HTLV-I infection_Homo sapiens_hsa051660.74454287
70Apoptosis_Homo sapiens_hsa042100.73484136
71Type I diabetes mellitus_Homo sapiens_hsa049400.73026320
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72802359
73Sulfur relay system_Homo sapiens_hsa041220.72133716
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.70787309
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.70315148
76Biosynthesis of amino acids_Homo sapiens_hsa012300.68734115
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67762505
78Chemokine signaling pathway_Homo sapiens_hsa040620.67135265
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65106409
80Hepatitis B_Homo sapiens_hsa051610.64746239
81Shigellosis_Homo sapiens_hsa051310.64712004
82Acute myeloid leukemia_Homo sapiens_hsa052210.61491852
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61025396
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.59895351
85Folate biosynthesis_Homo sapiens_hsa007900.59760633
86Non-small cell lung cancer_Homo sapiens_hsa052230.59161534
87Collecting duct acid secretion_Homo sapiens_hsa049660.58865402
88T cell receptor signaling pathway_Homo sapiens_hsa046600.57255522
89Osteoclast differentiation_Homo sapiens_hsa043800.55667797
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55333617
91Autoimmune thyroid disease_Homo sapiens_hsa053200.54720673
92Alzheimers disease_Homo sapiens_hsa050100.52750144
93Endocytosis_Homo sapiens_hsa041440.51527168
94Glutathione metabolism_Homo sapiens_hsa004800.51304448
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50718760
96Bladder cancer_Homo sapiens_hsa052190.50330494
97N-Glycan biosynthesis_Homo sapiens_hsa005100.50207233
98Galactose metabolism_Homo sapiens_hsa000520.49349241
99Notch signaling pathway_Homo sapiens_hsa043300.48596365
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47409242
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47384963
102African trypanosomiasis_Homo sapiens_hsa051430.45804364
103Vibrio cholerae infection_Homo sapiens_hsa051100.44641817
104Toxoplasmosis_Homo sapiens_hsa051450.43875513
105Synaptic vesicle cycle_Homo sapiens_hsa047210.42929525
106Hepatitis C_Homo sapiens_hsa051600.39952608
107Regulation of autophagy_Homo sapiens_hsa041400.39721203
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39589869
109Asthma_Homo sapiens_hsa053100.36960224
110Small cell lung cancer_Homo sapiens_hsa052220.35757021
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35347834
112Thyroid cancer_Homo sapiens_hsa052160.35224874
113Tuberculosis_Homo sapiens_hsa051520.35138917
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33510387
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33466480
116Carbon metabolism_Homo sapiens_hsa012000.30152001
117Viral myocarditis_Homo sapiens_hsa054160.26444908
118Graft-versus-host disease_Homo sapiens_hsa053320.26073579
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25212032
120Oocyte meiosis_Homo sapiens_hsa041140.24673108
121Colorectal cancer_Homo sapiens_hsa052100.23993338
122ABC transporters_Homo sapiens_hsa020100.23050050
123Pertussis_Homo sapiens_hsa051330.22845240
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22790447
125Chronic myeloid leukemia_Homo sapiens_hsa052200.21112709
126TNF signaling pathway_Homo sapiens_hsa046680.20836798

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »