ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	9.71632585
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	9.06471229
3	ATP synthesis coupled proton transport (GO:0015986)	9.06471229
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	8.65539501
5	respiratory electron transport chain (GO:0022904)	7.96628113
6	electron transport chain (GO:0022900)	7.77727591
7	ribosomal small subunit biogenesis (GO:0042274)	6.45694678
8	viral transcription (GO:0019083)	6.24032887
9	translational termination (GO:0006415)	6.00472945
10	ribosomal small subunit assembly (GO:0000028)	5.95926157
11	cotranslational protein targeting to membrane (GO:0006613)	5.83757707
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.82547639
13	protein targeting to ER (GO:0045047)	5.77846474
14	chaperone-mediated protein transport (GO:0072321)	5.62396068
15	protein localization to endoplasmic reticulum (GO:0070972)	5.53200738
16	protein complex biogenesis (GO:0070271)	5.52210446
17	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.51494592
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.43071196
19	NADH dehydrogenase complex assembly (GO:0010257)	5.43071196
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.43071196
21	protein neddylation (GO:0045116)	5.24136772
22	translational elongation (GO:0006414)	5.00777068
23	mitochondrial respiratory chain complex assembly (GO:0033108)	5.00106648
24	viral life cycle (GO:0019058)	4.81952567
25	cellular protein complex disassembly (GO:0043624)	4.80075138
26	hydrogen ion transmembrane transport (GO:1902600)	4.76606131
27	proteasome assembly (GO:0043248)	4.74310233
28	oxidative phosphorylation (GO:0006119)	4.69961963
29	ATP biosynthetic process (GO:0006754)	4.63488000
30	ribosomal large subunit biogenesis (GO:0042273)	4.62093981
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.59745372
32	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.55354711
33	maturation of SSU-rRNA (GO:0030490)	4.46960652
34	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.45520842
35	translation (GO:0006412)	4.36203807
36	regulation of mitochondrial translation (GO:0070129)	4.28792683
37	translational initiation (GO:0006413)	4.27305106
38	GTP biosynthetic process (GO:0006183)	4.26888200
39	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.18331112
40	proton transport (GO:0015992)	4.17314502
41	inner mitochondrial membrane organization (GO:0007007)	4.10780006
42	hydrogen transport (GO:0006818)	4.06919015
43	ribonucleoside triphosphate biosynthetic process (GO:0009201)	4.01818847
44	respiratory chain complex IV assembly (GO:0008535)	3.93788833
45	protein targeting to mitochondrion (GO:0006626)	3.93191807
46	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.93105433
47	termination of RNA polymerase III transcription (GO:0006386)	3.93105433
48	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.92754224
49	rRNA modification (GO:0000154)	3.92192793
50	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.91383703
51	protein complex disassembly (GO:0043241)	3.89425235
52	protein targeting to membrane (GO:0006612)	3.89022676
53	macromolecular complex disassembly (GO:0032984)	3.77465229
54	establishment of protein localization to mitochondrion (GO:0072655)	3.77149050
55	cytochrome complex assembly (GO:0017004)	3.73294036
56	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.60383239
57	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.60383239
58	pseudouridine synthesis (GO:0001522)	3.59243674
59	protein localization to mitochondrion (GO:0070585)	3.57991668
60	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.54466905
61	UTP biosynthetic process (GO:0006228)	3.53054632
62	peptidyl-histidine modification (GO:0018202)	3.52185734
63	nucleoside triphosphate biosynthetic process (GO:0009142)	3.49010095
64	aerobic respiration (GO:0009060)	3.47003251
65	cullin deneddylation (GO:0010388)	3.46153988
66	spliceosomal snRNP assembly (GO:0000387)	3.43153632
67	guanosine-containing compound biosynthetic process (GO:1901070)	3.41589199
68	mitochondrial transport (GO:0006839)	3.39742791
69	DNA deamination (GO:0045006)	3.38449317
70	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.38224651
71	regulation of cellular amino acid metabolic process (GO:0006521)	3.36694160
72	cellular component biogenesis (GO:0044085)	3.36322297
73	water-soluble vitamin biosynthetic process (GO:0042364)	3.35582380
74	chromatin remodeling at centromere (GO:0031055)	3.33370909
75	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.30422311
76	rRNA processing (GO:0006364)	3.30203061
77	7-methylguanosine mRNA capping (GO:0006370)	3.30198287
78	CENP-A containing nucleosome assembly (GO:0034080)	3.28848258
79	regulation of oxidative phosphorylation (GO:0002082)	3.28218396
80	intracellular protein transmembrane import (GO:0044743)	3.27416238
81	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.27041302
82	protein deneddylation (GO:0000338)	3.25222510
83	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.25110927
84	negative regulation of ligase activity (GO:0051352)	3.25110927
85	RNA capping (GO:0036260)	3.24791294
86	7-methylguanosine RNA capping (GO:0009452)	3.24791294
87	mRNA catabolic process (GO:0006402)	3.19667627
88	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.19335086
89	rRNA metabolic process (GO:0016072)	3.18131208
90	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.17486379
91	positive regulation of ligase activity (GO:0051351)	3.16594506
92	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.14726376
93	rRNA methylation (GO:0031167)	3.08711141
94	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.08555206
95	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.06423460
96	UTP metabolic process (GO:0046051)	3.04080826
97	CTP biosynthetic process (GO:0006241)	3.03867384
98	CTP metabolic process (GO:0046036)	3.03867384
99	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.00676893
100	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.00676893
101	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.99002317
102	RNA catabolic process (GO:0006401)	2.98042106
103	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.97598092
104	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.97598092
105	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.97598092
106	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.96776253
107	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.96680826
108	ribonucleoprotein complex biogenesis (GO:0022613)	2.95780723
109	protein targeting (GO:0006605)	2.95609935
110	spliceosomal complex assembly (GO:0000245)	2.95446004
111	ubiquinone biosynthetic process (GO:0006744)	2.90172340
112	quinone biosynthetic process (GO:1901663)	2.90172340
113	establishment of protein localization to membrane (GO:0090150)	2.89246215
114	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.87404178
115	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.87404178
116	signal peptide processing (GO:0006465)	2.85382649
117	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.84372774
118	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.83726776
119	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.83726776
120	protein-cofactor linkage (GO:0018065)	2.83424568
121	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.83336524

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.49373207
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.06438863
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.99255949
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.35597788
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.09447503
6	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.86574203
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.77343897
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.64942545
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.58356514
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.40221533
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.35299487
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	3.28878604
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.18241700
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.17816906
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.08198574
16	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.66916300
17	DCP1A_22483619_ChIP-Seq_HELA_Human	2.59417905
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.56017711
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.43921348
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.39846777
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.37703462
22	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.35729589
23	ELK1_19687146_ChIP-ChIP_HELA_Human	2.29380274
24	XRN2_22483619_ChIP-Seq_HELA_Human	2.22503309
25	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.19262486
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.16915385
27	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.12955081
28	TTF2_22483619_ChIP-Seq_HELA_Human	2.12751628
29	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.11237389
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.92539865
31	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.88693838
32	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.85891319
33	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.79147693
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.78702152
35	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.76273980
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.71458988
37	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.61753573
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.52570225
39	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.44578290
40	VDR_22108803_ChIP-Seq_LS180_Human	1.38477022
41	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.37975142
42	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.36502045
43	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34548088
44	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.33135326
45	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.28540378
46	EWS_26573619_Chip-Seq_HEK293_Human	1.27136664
47	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.25717862
48	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.25084155
49	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24929466
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.24560664
51	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.23419470
52	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.21868751
53	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.19797185
54	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.18786491
55	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.11617006
56	ZNF274_21170338_ChIP-Seq_K562_Hela	1.10926288
57	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.10381841
58	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.09808659
59	E2F7_22180533_ChIP-Seq_HELA_Human	1.08321281
60	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.07311747
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.06930630
62	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.06083063
63	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.03647836
64	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.03242243
65	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02835747
66	EZH2_22144423_ChIP-Seq_EOC_Human	1.02648880
67	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.02594670
68	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.00827264
69	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.00607747
70	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.99980296
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.99580915
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.99274845
73	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.97321652
74	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.97170852
75	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97094171
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.95645089
77	KDM5A_27292631_Chip-Seq_BREAST_Human	0.93664456
78	FUS_26573619_Chip-Seq_HEK293_Human	0.91067773
79	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.90498913
80	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89419156
81	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.89000333
82	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.87253000
83	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.87241827
84	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.86600254
85	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.85798970
86	ERG_20517297_ChIP-Seq_VCAP_Human	0.85344097
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.84186741
88	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.82393900
89	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.81995467
90	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.81168869
91	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.80790654
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.80602129
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.80602129
94	AR_20517297_ChIP-Seq_VCAP_Human	0.80380720
95	IRF1_19129219_ChIP-ChIP_H3396_Human	0.79262968
96	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.79187491
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.78389043
98	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.78199880
99	ELF5_23300383_ChIP-Seq_T47D_Human	0.77264269
100	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.74970735
101	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.73924511
102	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.73741537
103	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.73309948
104	NANOG_20526341_ChIP-Seq_ESCs_Human	0.73210977
105	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.73011430
106	STAT1_20625510_ChIP-Seq_HELA_Human	0.71806207
107	HTT_18923047_ChIP-ChIP_STHdh_Human	0.71643202
108	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.71262123
109	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.70916371
110	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.69438333
111	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.69292464
112	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.69099105
113	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.68724730
114	NANOG_19829295_ChIP-Seq_ESCs_Human	0.68369717
115	SOX2_19829295_ChIP-Seq_ESCs_Human	0.68369717
116	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.67516248
117	NCOR_22424771_ChIP-Seq_293T_Human	0.66787572
118	RBPJ_21746931_ChIP-Seq_IB4_Human	0.66259814
119	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.64860247
120	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.64052379
121	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.63928165
122	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.63884935
123	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.63252912
124	TP53_22573176_ChIP-Seq_HFKS_Human	0.63001012
125	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.62710814
126	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.61329597
127	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.60821748
128	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.60240726

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.23827776
2	MP0003806_abnormal_nucleotide_metabolis	4.66820588
3	MP0001529_abnormal_vocalization	3.18335740
4	MP0002837_dystrophic_cardiac_calcinosis	3.13077605
5	MP0006036_abnormal_mitochondrial_physio	3.09470773
6	MP0002638_abnormal_pupillary_reflex	3.01392353
7	MP0003646_muscle_fatigue	2.66427310
8	MP0003880_abnormal_central_pattern	2.59788938
9	MP0008058_abnormal_DNA_repair	2.58481259
10	MP0006276_abnormal_autonomic_nervous	2.46916402
11	MP0002163_abnormal_gland_morphology	2.44237253
12	MP0003136_yellow_coat_color	2.32713830
13	MP0001905_abnormal_dopamine_level	2.30383196
14	MP0004215_abnormal_myocardial_fiber	2.20785106
15	MP0000749_muscle_degeneration	2.08161213
16	MP0004043_abnormal_pH_regulation	2.06238267
17	MP0005379_endocrine/exocrine_gland_phen	2.01708836
18	MP0004142_abnormal_muscle_tone	1.93047152
19	MP0000372_irregular_coat_pigmentation	1.92408494
20	MP0010386_abnormal_urinary_bladder	1.90045837
21	MP0006035_abnormal_mitochondrial_morpho	1.89605552
22	MP0003315_abnormal_perineum_morphology	1.87085357
23	MP0001188_hyperpigmentation	1.85483809
24	MP0003186_abnormal_redox_activity	1.82290729
25	MP0003221_abnormal_cardiomyocyte_apopto	1.71743463
26	MP0010094_abnormal_chromosome_stability	1.68780551
27	MP0006072_abnormal_retinal_apoptosis	1.65761841
28	MP0000751_myopathy	1.54586033
29	MP0008995_early_reproductive_senescence	1.49182619
30	MP0008875_abnormal_xenobiotic_pharmacok	1.48968019
31	MP0003077_abnormal_cell_cycle	1.47423518
32	MP0003724_increased_susceptibility_to	1.46587370
33	MP0001764_abnormal_homeostasis	1.45506862
34	MP0008004_abnormal_stomach_pH	1.45428876
35	MP0008007_abnormal_cellular_replicative	1.42742446
36	MP0006292_abnormal_olfactory_placode	1.41368441
37	MP0004036_abnormal_muscle_relaxation	1.40665245
38	MP0004957_abnormal_blastocyst_morpholog	1.38627191
39	MP0004147_increased_porphyrin_level	1.38565461
40	MP0001986_abnormal_taste_sensitivity	1.37582824
41	MP0005330_cardiomyopathy	1.36651136
42	MP0008872_abnormal_physiological_respon	1.36416579
43	MP0008932_abnormal_embryonic_tissue	1.34801696
44	MP0003693_abnormal_embryo_hatching	1.34320195
45	MP0003111_abnormal_nucleus_morphology	1.31458035
46	MP0005551_abnormal_eye_electrophysiolog	1.30871072
47	MP0002095_abnormal_skin_pigmentation	1.30865230
48	MP0003786_premature_aging	1.29480688
49	MP0002751_abnormal_autonomic_nervous	1.28330400
50	MP0002736_abnormal_nociception_after	1.26850990
51	MP0003011_delayed_dark_adaptation	1.26681557
52	MP0000013_abnormal_adipose_tissue	1.26271303
53	MP0002277_abnormal_respiratory_mucosa	1.25902443
54	MP0004145_abnormal_muscle_electrophysio	1.21085239
55	MP0002160_abnormal_reproductive_system	1.19986802
56	MP0005636_abnormal_mineral_homeostasis	1.19672189
57	MP0005332_abnormal_amino_acid	1.18526825
58	MP0001485_abnormal_pinna_reflex	1.17258528
59	MP0003137_abnormal_impulse_conducting	1.16512973
60	MP0002102_abnormal_ear_morphology	1.16272298
61	MP0005646_abnormal_pituitary_gland	1.15226118
62	MP0005084_abnormal_gallbladder_morpholo	1.12852394
63	MP0001968_abnormal_touch/_nociception	1.11598727
64	MP0005408_hypopigmentation	1.11337462
65	MP0002938_white_spotting	1.10914561
66	MP0001970_abnormal_pain_threshold	1.10427803
67	MP0005389_reproductive_system_phenotype	1.10097059
68	MP0003195_calcinosis	1.06656225
69	MP0002972_abnormal_cardiac_muscle	1.06613059
70	MP0005075_abnormal_melanosome_morpholog	1.05202237
71	MP0005409_darkened_coat_color	1.04608451
72	MP0001984_abnormal_olfaction	1.04417075
73	MP0002148_abnormal_hypersensitivity_rea	1.03464695
74	MP0004084_abnormal_cardiac_muscle	1.02947063
75	MP0003718_maternal_effect	1.02391554
76	MP0010030_abnormal_orbit_morphology	1.01896933
77	MP0002272_abnormal_nervous_system	1.00671718
78	MP0001440_abnormal_grooming_behavior	1.00607634
79	MP0004742_abnormal_vestibular_system	1.00083790
80	MP0001727_abnormal_embryo_implantation	1.00066411
81	MP0000343_altered_response_to	0.99782988
82	MP0000631_abnormal_neuroendocrine_gland	0.99585905
83	MP0008877_abnormal_DNA_methylation	0.98682788
84	MP0001919_abnormal_reproductive_system	0.98363434
85	MP0002734_abnormal_mechanical_nocicepti	0.97532232
86	MP0004381_abnormal_hair_follicle	0.97226091
87	MP0002106_abnormal_muscle_physiology	0.97035213
88	MP0002735_abnormal_chemical_nociception	0.95574078
89	MP0002733_abnormal_thermal_nociception	0.95525781
90	MP0005410_abnormal_fertilization	0.95507197
91	MP0001664_abnormal_digestion	0.94953492
92	MP0002822_catalepsy	0.94584676
93	MP0002009_preneoplasia	0.94480765
94	MP0000750_abnormal_muscle_regeneration	0.93318833
95	MP0002332_abnormal_exercise_endurance	0.92229811
96	MP0005171_absent_coat_pigmentation	0.91431995
97	MP0009697_abnormal_copulation	0.90922485
98	MP0005266_abnormal_metabolism	0.89531368
99	MP0001293_anophthalmia	0.89327158
100	MP0002210_abnormal_sex_determination	0.88077073
101	MP0002876_abnormal_thyroid_physiology	0.87694940
102	MP0005174_abnormal_tail_pigmentation	0.86987039
103	MP0004019_abnormal_vitamin_homeostasis	0.85740549
104	MP0002653_abnormal_ependyma_morphology	0.84426796
105	MP0005645_abnormal_hypothalamus_physiol	0.84407311
106	MP0008789_abnormal_olfactory_epithelium	0.83979261
107	MP0005620_abnormal_muscle_contractility	0.82712974
108	MP0000358_abnormal_cell_content/	0.82639670
109	MP0003941_abnormal_skin_development	0.82326659
110	MP0004924_abnormal_behavior	0.81893433
111	MP0005386_behavior/neurological_phenoty	0.81893433
112	MP0009046_muscle_twitch	0.81450357
113	MP0000049_abnormal_middle_ear	0.81086294
114	MP0003123_paternal_imprinting	0.80509504
115	MP0000230_abnormal_systemic_arterial	0.80094537
116	MP0000538_abnormal_urinary_bladder	0.78715264
117	MP0002693_abnormal_pancreas_physiology	0.77955584
118	MP0003638_abnormal_response/metabolism_	0.77936525
119	MP0005369_muscle_phenotype	0.77190038
120	MP0008775_abnormal_heart_ventricle	0.77021672
121	MP0002132_abnormal_respiratory_system	0.76327091
122	MP0009745_abnormal_behavioral_response	0.75967815
123	MP0005535_abnormal_body_temperature	0.75651638
124	MP0001542_abnormal_bone_strength	0.75531726
125	MP0003122_maternal_imprinting	0.73958806
126	MP0003121_genomic_imprinting	0.72816715
127	MP0002090_abnormal_vision	0.71672476
128	MP0005253_abnormal_eye_physiology	0.70429538
129	MP0004484_altered_response_of	0.69874429
130	MP0003283_abnormal_digestive_organ	0.69848727
131	MP0001929_abnormal_gametogenesis	0.69817144
132	MP0002067_abnormal_sensory_capabilities	0.69509314
133	MP0009785_altered_susceptibility_to	0.68959103
134	MP0001756_abnormal_urination	0.68951612
135	MP0001881_abnormal_mammary_gland	0.68889912
136	MP0002064_seizures	0.68342064
137	MP0000653_abnormal_sex_gland	0.68339451
138	MP0000462_abnormal_digestive_system	0.68278391
139	MP0004133_heterotaxia	0.66929529
140	MP0002234_abnormal_pharynx_morphology	0.66777740
141	MP0001145_abnormal_male_reproductive	0.64519206
142	MP0005195_abnormal_posterior_eye	0.64464941
143	MP0003938_abnormal_ear_development	0.60866865

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	7.66862872
2	Abnormal mitochondria in muscle tissue (HP:0008316)	6.99300511
3	Mitochondrial inheritance (HP:0001427)	6.80358529
4	Progressive macrocephaly (HP:0004481)	6.39631608
5	Acute encephalopathy (HP:0006846)	6.28752399
6	Hepatocellular necrosis (HP:0001404)	5.96024012
7	Increased CSF lactate (HP:0002490)	5.77088135
8	Hepatic necrosis (HP:0002605)	5.54388607
9	Increased hepatocellular lipid droplets (HP:0006565)	5.41844542
10	Lipid accumulation in hepatocytes (HP:0006561)	5.05346801
11	Abnormality of cells of the erythroid lineage (HP:0012130)	4.55237036
12	Renal Fanconi syndrome (HP:0001994)	4.50525528
13	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	4.49026381
14	Abnormal number of erythroid precursors (HP:0012131)	4.33088273
15	Increased intramyocellular lipid droplets (HP:0012240)	4.29936883
16	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.27370363
17	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.27370363
18	Cerebral edema (HP:0002181)	4.15962097
19	Exercise intolerance (HP:0003546)	4.15332291
20	Respiratory failure (HP:0002878)	4.07146552
21	Optic disc pallor (HP:0000543)	3.99460834
22	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.95351143
23	Reticulocytopenia (HP:0001896)	3.86941604
24	Increased muscle lipid content (HP:0009058)	3.85214282
25	Lactic acidosis (HP:0003128)	3.83761057
26	Exertional dyspnea (HP:0002875)	3.79601645
27	Increased serum lactate (HP:0002151)	3.74110227
28	3-Methylglutaconic aciduria (HP:0003535)	3.64445211
29	Macrocytic anemia (HP:0001972)	3.42070223
30	Leukodystrophy (HP:0002415)	3.34899654
31	Increased serum pyruvate (HP:0003542)	3.30881889
32	Abnormality of glycolysis (HP:0004366)	3.30881889
33	Respiratory difficulties (HP:0002880)	3.03410391
34	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.02894970
35	Abnormality of renal resorption (HP:0011038)	2.99241238
36	Pallor (HP:0000980)	2.90685256
37	Abnormal hemoglobin (HP:0011902)	2.88772295
38	Glycosuria (HP:0003076)	2.74730971
39	Abnormality of urine glucose concentration (HP:0011016)	2.74730971
40	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.71594378
41	Hyperphosphaturia (HP:0003109)	2.65459253
42	Neuroendocrine neoplasm (HP:0100634)	2.61878280
43	CNS demyelination (HP:0007305)	2.53312316
44	Pheochromocytoma (HP:0002666)	2.44382760
45	Molar tooth sign on MRI (HP:0002419)	2.43224031
46	Abnormality of midbrain morphology (HP:0002418)	2.43224031
47	X-linked dominant inheritance (HP:0001423)	2.41786809
48	Emotional lability (HP:0000712)	2.39262397
49	Pancreatic fibrosis (HP:0100732)	2.36856533
50	Aplasia/hypoplasia of the uterus (HP:0008684)	2.27615939
51	Hypothermia (HP:0002045)	2.24373954
52	Parakeratosis (HP:0001036)	2.18408455
53	Abnormality of the anterior horn cell (HP:0006802)	2.18370158
54	Degeneration of anterior horn cells (HP:0002398)	2.18370158
55	Lethargy (HP:0001254)	2.17837748
56	Abnormality of alanine metabolism (HP:0010916)	2.16707683
57	Hyperalaninemia (HP:0003348)	2.16707683
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.16707683
59	Oral leukoplakia (HP:0002745)	2.13279706
60	Abnormal urine phosphate concentration (HP:0012599)	2.12824188
61	Pancytopenia (HP:0001876)	2.11766961
62	Abnormal pupillary function (HP:0007686)	2.08019673
63	True hermaphroditism (HP:0010459)	2.04444908
64	Aplastic anemia (HP:0001915)	2.04290591
65	Abnormality of methionine metabolism (HP:0010901)	1.99814468
66	Myokymia (HP:0002411)	1.99631162
67	Microvesicular hepatic steatosis (HP:0001414)	1.99346460
68	Renal tubular dysfunction (HP:0000124)	1.99253178
69	Type I transferrin isoform profile (HP:0003642)	1.97527155
70	Generalized aminoaciduria (HP:0002909)	1.95139010
71	Congenital ichthyosiform erythroderma (HP:0007431)	1.94417764
72	Reduced antithrombin III activity (HP:0001976)	1.91450909
73	Gliosis (HP:0002171)	1.90181762
74	Sclerocornea (HP:0000647)	1.88723822
75	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.88555983
76	Abnormality of serum amino acid levels (HP:0003112)	1.88429227
77	Palpitations (HP:0001962)	1.87265095
78	Cleft eyelid (HP:0000625)	1.84471230
79	Absent thumb (HP:0009777)	1.80680927
80	Megaloblastic anemia (HP:0001889)	1.80617427
81	Hypoplasia of the uterus (HP:0000013)	1.80491966
82	Congenital sensorineural hearing impairment (HP:0008527)	1.79093477
83	Muscle hypertrophy of the lower extremities (HP:0008968)	1.77883810
84	Hyperglycinemia (HP:0002154)	1.74623527
85	Nephronophthisis (HP:0000090)	1.73573709
86	Congenital stationary night blindness (HP:0007642)	1.71080298
87	Amniotic constriction ring (HP:0009775)	1.70880811
88	Abnormality of placental membranes (HP:0011409)	1.70880811
89	Conjunctival hamartoma (HP:0100780)	1.70489810
90	Methylmalonic aciduria (HP:0012120)	1.70475072
91	Congenital, generalized hypertrichosis (HP:0004540)	1.69797356
92	Blindness (HP:0000618)	1.67159856
93	Sparse eyelashes (HP:0000653)	1.66450657
94	Abnormality of vitamin B metabolism (HP:0004340)	1.66387174
95	Dicarboxylic aciduria (HP:0003215)	1.65129016
96	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.65129016
97	Vomiting (HP:0002013)	1.63376215
98	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.61884199
99	Hepatosplenomegaly (HP:0001433)	1.61642651
100	Medial flaring of the eyebrow (HP:0010747)	1.61284579
101	Calf muscle hypertrophy (HP:0008981)	1.60967392
102	Colon cancer (HP:0003003)	1.60089744
103	Meckel diverticulum (HP:0002245)	1.55717456
104	Male pseudohermaphroditism (HP:0000037)	1.54822988
105	Cerebral hypomyelination (HP:0006808)	1.53487234
106	Sudden death (HP:0001699)	1.53293619
107	Methylmalonic acidemia (HP:0002912)	1.53127870
108	Pendular nystagmus (HP:0012043)	1.51345051
109	Neoplasm of head and neck (HP:0012288)	1.49317113
110	Esophageal neoplasm (HP:0100751)	1.49317113
111	Secondary amenorrhea (HP:0000869)	1.48250421
112	Progressive external ophthalmoplegia (HP:0000590)	1.47222182
113	Nausea (HP:0002018)	1.44578050
114	Testicular atrophy (HP:0000029)	1.43388955
115	Unsteady gait (HP:0002317)	1.41953600
116	Abnormal protein N-linked glycosylation (HP:0012347)	1.41543979
117	Abnormal protein glycosylation (HP:0012346)	1.41543979
118	Abnormal glycosylation (HP:0012345)	1.41543979
119	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.41543979
120	Proximal tubulopathy (HP:0000114)	1.40686614
121	Rough bone trabeculation (HP:0100670)	1.35700956
122	Progressive microcephaly (HP:0000253)	1.34674853
123	Myotonia (HP:0002486)	1.30833967
124	Ragged-red muscle fibers (HP:0003200)	1.30033564
125	Pancreatic cysts (HP:0001737)	1.29930729
126	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.29763664

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.62125054
2	NME2	4.21393746
3	NME1	3.86577618
4	PBK	3.75468143
5	MAP3K12	3.26327917
6	STK16	2.82866835
7	BUB1	2.53661751
8	CDC7	2.42223150
9	TLK1	2.35146574
10	EIF2AK1	2.32892022
11	MYLK	2.13524417
12	VRK1	2.07534098
13	MAP2K7	2.01783037
14	PIM2	1.99884805
15	MST4	1.96722462
16	ARAF	1.94235832
17	STK39	1.92739964
18	WNK4	1.89098832
19	NEK1	1.87161874
20	GRK7	1.75777578
21	LIMK1	1.74197058
22	EIF2AK3	1.70097197
23	MAP4K2	1.68953254
24	NUAK1	1.68670037
25	MUSK	1.57555690
26	IRAK3	1.56555494
27	GRK1	1.50998174
28	OBSCN	1.42469964
29	CDK19	1.39808294
30	PDK2	1.38576937
31	PLK3	1.37300091
32	WNK3	1.34932279
33	BCR	1.31104101
34	WEE1	1.29028842
35	TESK2	1.27087358
36	BMPR2	1.23309164
37	SRPK1	1.22491602
38	PINK1	1.19980310
39	ABL2	1.19708972
40	OXSR1	1.17589031
41	CASK	1.14835576
42	PLK4	1.14253542
43	MAP3K4	1.12096343
44	MAP3K11	1.10672259
45	BRAF	1.08405156
46	GRK5	1.08131761
47	IRAK4	1.04884271
48	TESK1	1.02497429
49	MAP3K6	1.01704953
50	TTK	1.01614492
51	INSRR	0.97830190
52	TNIK	0.97634437
53	CSNK1G2	0.93728296
54	DYRK2	0.93475906
55	ADRBK1	0.92716637
56	ADRBK2	0.92523879
57	PIK3CG	0.92060456
58	BMPR1B	0.90660793
59	MAPKAPK5	0.89849436
60	CCNB1	0.88789968
61	IRAK1	0.88564047
62	CSNK1G1	0.87892977
63	FRK	0.85724911
64	MAPK15	0.84986479
65	ACVR1B	0.83437319
66	CDK8	0.82691418
67	RIPK4	0.82418640
68	UHMK1	0.79782323
69	CAMK2D	0.77157344
70	CHEK2	0.76788775
71	TAF1	0.75919133
72	LMTK2	0.75877541
73	BCKDK	0.70633958
74	MKNK1	0.68937275
75	CSNK1A1L	0.68513352
76	ILK	0.68041564
77	DAPK3	0.67672885
78	MKNK2	0.67610987
79	AURKA	0.67327623
80	PRKCG	0.66025886
81	IRAK2	0.65783157
82	DAPK1	0.64273774
83	TIE1	0.62503295
84	PNCK	0.61154630
85	ZAK	0.60762423
86	CDK14	0.60493028
87	TRIM28	0.59888393
88	PASK	0.59166419
89	CAMK2B	0.57995275
90	CSNK2A1	0.57284312
91	MAP2K4	0.56466168
92	ATR	0.56089609
93	RPS6KA5	0.55314634
94	BRSK1	0.52520084
95	CAMK2G	0.51277912
96	KDR	0.51241528
97	DYRK3	0.50746725
98	CDK11A	0.50100807
99	CAMK2A	0.49365030
100	STK24	0.48256358
101	PRKCE	0.47356690
102	STK38L	0.47321665
103	AURKB	0.47313228
104	TXK	0.47258194
105	PAK4	0.46590399
106	CSNK2A2	0.46518198
107	PLK2	0.45950310
108	YES1	0.45615566
109	CDK18	0.45129478
110	STK4	0.44376726
111	BLK	0.44202485
112	MAP3K5	0.44140130
113	CDK15	0.43853111
114	CDK3	0.43693565
115	EIF2AK2	0.43528760
116	IKBKB	0.43058749
117	PRKACA	0.41874936
118	CSNK1A1	0.41699474
119	MINK1	0.41678401
120	MAPK4	0.41214231
121	CSNK1G3	0.40977574
122	TAOK3	0.39444535
123	PHKG2	0.39418311
124	PHKG1	0.39418311
125	MAPKAPK3	0.37380736
126	PIK3CA	0.37267862
127	CSNK1E	0.36853628
128	PRKCI	0.35598734
129	NEK9	0.34636907
130	TEC	0.33381073
131	PLK1	0.32472654
132	PAK1	0.32233221
133	FES	0.32223522
134	BRSK2	0.30655958

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	6.29447355
2	Parkinsons disease_Homo sapiens_hsa05012	5.48400466
3	Ribosome_Homo sapiens_hsa03010	5.15054687
4	Alzheimers disease_Homo sapiens_hsa05010	4.09929498
5	Huntingtons disease_Homo sapiens_hsa05016	3.98840262
6	Proteasome_Homo sapiens_hsa03050	3.61800453
7	Protein export_Homo sapiens_hsa03060	3.52367381
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	3.51104005
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.79335704
10	RNA polymerase_Homo sapiens_hsa03020	2.77790127
11	DNA replication_Homo sapiens_hsa03030	1.96238294
12	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.68727073
13	Pyrimidine metabolism_Homo sapiens_hsa00240	1.64766359
14	One carbon pool by folate_Homo sapiens_hsa00670	1.43771356
15	Homologous recombination_Homo sapiens_hsa03440	1.42599247
16	Collecting duct acid secretion_Homo sapiens_hsa04966	1.39999710
17	Mismatch repair_Homo sapiens_hsa03430	1.36631845
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.32072511
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30414962
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.30340316
21	Sulfur metabolism_Homo sapiens_hsa00920	1.24690965
22	Fatty acid elongation_Homo sapiens_hsa00062	1.24556566
23	Spliceosome_Homo sapiens_hsa03040	1.22599141
24	Vibrio cholerae infection_Homo sapiens_hsa05110	1.22582416
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.18934729
26	Basal transcription factors_Homo sapiens_hsa03022	1.07263067
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.07234290
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.06086862
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.00630686
30	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.98417344
31	Purine metabolism_Homo sapiens_hsa00230	0.97433677
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.85536267
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.84296089
34	Glutathione metabolism_Homo sapiens_hsa00480	0.81509215
35	Metabolic pathways_Homo sapiens_hsa01100	0.81382984
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78881938
37	Folate biosynthesis_Homo sapiens_hsa00790	0.77926071
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.75568481
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71215656
40	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69646413
41	Base excision repair_Homo sapiens_hsa03410	0.65682721
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.65024936
43	Sulfur relay system_Homo sapiens_hsa04122	0.64723420
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63334730
45	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.61621218
46	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61581649
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.59886772
48	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.58618682
49	RNA degradation_Homo sapiens_hsa03018	0.57222516
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.56158216
51	Pyruvate metabolism_Homo sapiens_hsa00620	0.55900410
52	Sphingolipid metabolism_Homo sapiens_hsa00600	0.55731353
53	Propanoate metabolism_Homo sapiens_hsa00640	0.55375347
54	Linoleic acid metabolism_Homo sapiens_hsa00591	0.51955462
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.50678957
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50129581
57	RNA transport_Homo sapiens_hsa03013	0.49020062
58	Serotonergic synapse_Homo sapiens_hsa04726	0.48687285
59	Fanconi anemia pathway_Homo sapiens_hsa03460	0.44099508
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.44029747
61	Phagosome_Homo sapiens_hsa04145	0.43554544
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.43034343
63	Carbon metabolism_Homo sapiens_hsa01200	0.42436066
64	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.41810168
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40868851
66	Phototransduction_Homo sapiens_hsa04744	0.40169227
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37131666
68	Tyrosine metabolism_Homo sapiens_hsa00350	0.35448011
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35097038
70	Graft-versus-host disease_Homo sapiens_hsa05332	0.34648580
71	Retinol metabolism_Homo sapiens_hsa00830	0.34512088
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.34107560
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.33853390
74	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.32825154
75	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.32597995
76	Fatty acid degradation_Homo sapiens_hsa00071	0.32513640
77	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.31724249
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30354984
79	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.29985809
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.29864887
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.29767118
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.29238329
83	Cell cycle_Homo sapiens_hsa04110	0.28777869
84	Caffeine metabolism_Homo sapiens_hsa00232	0.28502794
85	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.28444323
86	Type I diabetes mellitus_Homo sapiens_hsa04940	0.28260849
87	Asthma_Homo sapiens_hsa05310	0.27336146
88	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.27122895
89	Regulation of autophagy_Homo sapiens_hsa04140	0.26140334
90	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.26095147
91	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.24784674
92	Other glycan degradation_Homo sapiens_hsa00511	0.24019759
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.23089861
94	Phenylalanine metabolism_Homo sapiens_hsa00360	0.22802768
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22765633
96	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.21041952
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.20983711
98	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.20502308
99	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.19979704
100	Pentose phosphate pathway_Homo sapiens_hsa00030	0.19365024
101	Taste transduction_Homo sapiens_hsa04742	0.19050796
102	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.18811691
103	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.16726443
104	Fatty acid metabolism_Homo sapiens_hsa01212	0.16243521
105	p53 signaling pathway_Homo sapiens_hsa04115	0.16193078
106	Olfactory transduction_Homo sapiens_hsa04740	0.15845604
107	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.15549415
108	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.15080922
109	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.14951784
110	Alcoholism_Homo sapiens_hsa05034	0.14157098
111	Steroid biosynthesis_Homo sapiens_hsa00100	0.12173625
112	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.12054783
113	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.11986628
114	Allograft rejection_Homo sapiens_hsa05330	0.11870515
115	Histidine metabolism_Homo sapiens_hsa00340	0.11664162
116	Nicotine addiction_Homo sapiens_hsa05033	0.11573942
117	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.11147399
118	Oocyte meiosis_Homo sapiens_hsa04114	0.10912537
119	Dopaminergic synapse_Homo sapiens_hsa04728	0.10649933
120	Galactose metabolism_Homo sapiens_hsa00052	0.10033540
121	Mineral absorption_Homo sapiens_hsa04978	0.09086899
122	Peroxisome_Homo sapiens_hsa04146	0.08698825
123	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.07736289
124	Pertussis_Homo sapiens_hsa05133	0.07703002
125	Pancreatic secretion_Homo sapiens_hsa04972	0.07497254
126	Malaria_Homo sapiens_hsa05144	0.07228126
127	Butanoate metabolism_Homo sapiens_hsa00650	0.06166926
128	Legionellosis_Homo sapiens_hsa05134	0.05011177
129	GABAergic synapse_Homo sapiens_hsa04727	0.04830391
130	Long-term depression_Homo sapiens_hsa04730	0.04407031
131	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.03235034

MINOS1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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