MINOS1-NBL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring chromosome 1 open reading frame 151 (GeneID 440574) and neuroblastoma suppressor of tumorigenicity 1 (GeneID 4681) genes on chromosome 1. The read-through transcripts produce at least two proteins, each of which share identity with proteins translated from the downstream neuroblastoma suppressor of tumorigenicity 1 locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.08568927
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.53571893
3ATP synthesis coupled proton transport (GO:0015986)5.53571893
4proteasome assembly (GO:0043248)5.47903421
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.37751018
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.14105838
7chaperone-mediated protein transport (GO:0072321)5.08007000
8respiratory electron transport chain (GO:0022904)4.88608272
9electron transport chain (GO:0022900)4.74354700
10regulation of mitochondrial translation (GO:0070129)4.21183532
11transcription elongation from RNA polymerase III promoter (GO:0006385)4.01982876
12termination of RNA polymerase III transcription (GO:0006386)4.01982876
13deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.97747651
14ribosomal small subunit assembly (GO:0000028)3.93018778
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.80370195
16protein targeting to ER (GO:0045047)3.79846592
17cotranslational protein targeting to membrane (GO:0006613)3.78199938
18protein heterotrimerization (GO:0070208)3.74314242
19viral transcription (GO:0019083)3.74205717
20establishment of protein localization to endoplasmic reticulum (GO:0072599)3.60374698
21protein localization to endoplasmic reticulum (GO:0070972)3.57314245
22pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.57014220
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.56937157
24translational termination (GO:0006415)3.56269091
25ribosomal small subunit biogenesis (GO:0042274)3.50287526
26protein targeting to mitochondrion (GO:0006626)3.49028066
27pseudouridine synthesis (GO:0001522)3.36710488
28negative regulation of ligase activity (GO:0051352)3.36697938
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36697938
30ribosomal large subunit biogenesis (GO:0042273)3.35027165
31rRNA modification (GO:0000154)3.34874330
32establishment of protein localization to mitochondrion (GO:0072655)3.30525596
33regulation of cellular amino acid metabolic process (GO:0006521)3.29935851
34protein maturation by protein folding (GO:0022417)3.27697668
35spliceosomal snRNP assembly (GO:0000387)3.27499728
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27011715
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.26158809
38aerobic respiration (GO:0009060)3.25019540
39CENP-A containing nucleosome assembly (GO:0034080)3.23024031
40GDP-mannose metabolic process (GO:0019673)3.22242875
41translation (GO:0006412)3.21767888
42translational elongation (GO:0006414)3.20989265
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19752886
44maturation of SSU-rRNA (GO:0030490)3.19189556
45protein localization to mitochondrion (GO:0070585)3.17555868
46pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.16476882
47protein complex biogenesis (GO:0070271)3.09316804
48nucleobase-containing small molecule interconversion (GO:0015949)3.07835172
49chromatin remodeling at centromere (GO:0031055)3.06937073
50hydrogen ion transmembrane transport (GO:1902600)3.06348218
51cell migration involved in heart development (GO:0060973)3.04890843
527-methylguanosine mRNA capping (GO:0006370)2.99820761
53mitochondrial transport (GO:0006839)2.99493425
54deoxyribose phosphate biosynthetic process (GO:0046385)2.98539388
552-deoxyribonucleotide biosynthetic process (GO:0009265)2.98539388
56viral life cycle (GO:0019058)2.98475666
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97991922
58positive regulation of actin filament depolymerization (GO:0030836)2.97905719
59establishment of integrated proviral latency (GO:0075713)2.97178883
60protein neddylation (GO:0045116)2.91693473
61pyrimidine nucleotide catabolic process (GO:0006244)2.91453158
62signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89851148
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89851148
64RNA capping (GO:0036260)2.89573551
657-methylguanosine RNA capping (GO:0009452)2.89573551
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88651250
67signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88651250
68signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88651250
69mitochondrial respiratory chain complex assembly (GO:0033108)2.88509377
70translational initiation (GO:0006413)2.86680377
71mitochondrial respiratory chain complex I assembly (GO:0032981)2.84964946
72NADH dehydrogenase complex assembly (GO:0010257)2.84964946
73mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84964946
74mitochondrial calcium ion transport (GO:0006851)2.84275972
75cellular response to vitamin D (GO:0071305)2.83962632
76cellular protein complex disassembly (GO:0043624)2.83250871
77regulation of translational termination (GO:0006449)2.83125451
78signal transduction involved in DNA integrity checkpoint (GO:0072401)2.81444117
79signal transduction involved in DNA damage checkpoint (GO:0072422)2.81444117
80regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.81286665
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80174213
82nuclear envelope reassembly (GO:0031468)2.79366820
83mitotic nuclear envelope reassembly (GO:0007084)2.79366820
84muscle cell migration (GO:0014812)2.79361122
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78155241
86positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.77171193
87deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.76440490
88deoxyribonucleotide biosynthetic process (GO:0009263)2.75666593
89signal transduction involved in cell cycle checkpoint (GO:0072395)2.74043680
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.73820432
91positive regulation of calcium ion import (GO:0090280)2.73784940
92nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.73121599
93ATP biosynthetic process (GO:0006754)2.70446184
94proton transport (GO:0015992)2.69751489
95hydrogen transport (GO:0006818)2.66992299
96sequestering of actin monomers (GO:0042989)2.66256004
97hemidesmosome assembly (GO:0031581)2.64993960
98regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64885747
99protein targeting to membrane (GO:0006612)2.64570897
100positive regulation of ligase activity (GO:0051351)2.63179754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.40699149
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.36040954
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.25681949
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.84451905
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81183442
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66578406
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.24097074
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.19304308
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.16282375
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.06068080
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02139852
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.00406978
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.93580923
14E2F7_22180533_ChIP-Seq_HELA_Human2.62864206
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57204588
16E2F1_18555785_ChIP-Seq_MESCs_Mouse2.52278699
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49772171
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40682291
19ZNF263_19887448_ChIP-Seq_K562_Human2.40646713
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36648762
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35286123
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.29805442
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25329264
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.23343608
25AR_21909140_ChIP-Seq_LNCAP_Human2.22324302
26DCP1A_22483619_ChIP-Seq_HELA_Human2.20605639
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.19492192
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.18252990
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02024542
30XRN2_22483619_ChIP-Seq_HELA_Human1.97847337
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94072594
32TTF2_22483619_ChIP-Seq_HELA_Human1.91563308
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86422480
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.84891553
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78862393
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78301112
37ELK1_19687146_ChIP-ChIP_HELA_Human1.77008215
38GABP_19822575_ChIP-Seq_HepG2_Human1.76366321
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75782476
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73323749
41ELK1_22589737_ChIP-Seq_MCF10A_Human1.65765634
42FOXP3_21729870_ChIP-Seq_TREG_Human1.65226076
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.64963292
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63994174
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61753281
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.53158836
47VDR_23849224_ChIP-Seq_CD4+_Human1.51905341
48HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.47904871
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46466587
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39357669
51ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37806059
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35250408
53CTCF_18555785_ChIP-Seq_MESCs_Mouse1.34873399
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32681960
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29593066
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29061084
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25875738
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20387629
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.19747508
60CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19685905
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19105946
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16848257
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14991572
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14401092
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11375309
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10466335
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09943756
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09887634
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09528018
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09224092
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08408529
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03137455
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02315596
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01459908
75SA1_22415368_ChIP-Seq_MEFs_Mouse0.99978968
76ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99559604
77OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99419999
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98389673
79E2F1_21310950_ChIP-Seq_MCF-7_Human0.97395720
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97128545
81HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96888249
82MYC_18940864_ChIP-ChIP_HL60_Human0.96768948
83TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95938920
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95602719
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95067191
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94131515
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.93225429
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93015556
89CTCF_26484167_Chip-Seq_Bcells_Mouse0.91699491
90CDX2_20551321_ChIP-Seq_CACO-2_Human0.90467896
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89538578
92TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88370799
93KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88119093
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87949187
95SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87557799
96ELF5_23300383_ChIP-Seq_T47D_Human0.85881396
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84182973
98SMC3_22415368_ChIP-Seq_MEFs_Mouse0.83011109
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82069522
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.82040917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.51930649
2MP0005503_abnormal_tendon_morphology4.16580999
3MP0009379_abnormal_foot_pigmentation3.98270059
4MP0000678_abnormal_parathyroid_gland3.44935509
5MP0003941_abnormal_skin_development3.02939545
6MP0005275_abnormal_skin_tensile2.94174942
7MP0004272_abnormal_basement_membrane2.88238401
8MP0001542_abnormal_bone_strength2.77462745
9MP0003950_abnormal_plasma_membrane2.72530040
10MP0003705_abnormal_hypodermis_morpholog2.70415634
11MP0003693_abnormal_embryo_hatching2.68840693
12MP0001958_emphysema2.43225541
13MP0005257_abnormal_intraocular_pressure2.32753690
14MP0010368_abnormal_lymphatic_system2.29764937
15MP0000013_abnormal_adipose_tissue2.22321462
16MP0002060_abnormal_skin_morphology2.21831610
17MP0005023_abnormal_wound_healing2.20904901
18MP0003806_abnormal_nucleotide_metabolis2.15754474
19MP0003283_abnormal_digestive_organ2.04877460
20MP0005508_abnormal_skeleton_morphology2.03997686
21MP0009053_abnormal_anal_canal2.00570498
22MP0003279_aneurysm1.85373056
23MP0000762_abnormal_tongue_morphology1.85151494
24MP0004782_abnormal_surfactant_physiolog1.84742842
25MP0003566_abnormal_cell_adhesion1.82529382
26MP0002796_impaired_skin_barrier1.76334846
27MP0004957_abnormal_blastocyst_morpholog1.67757295
28MP0008932_abnormal_embryonic_tissue1.65590602
29MP0009250_abnormal_appendicular_skeleto1.60806230
30MP0009384_cardiac_valve_regurgitation1.59022521
31MP0000467_abnormal_esophagus_morphology1.57397806
32MP0003186_abnormal_redox_activity1.53350084
33MP0001243_abnormal_dermal_layer1.51791527
34MP0000579_abnormal_nail_morphology1.49565968
35MP0002877_abnormal_melanocyte_morpholog1.36405360
36MP0002139_abnormal_hepatobiliary_system1.34379067
37MP0001881_abnormal_mammary_gland1.28165387
38MP0000534_abnormal_ureter_morphology1.27932184
39MP0000751_myopathy1.27126515
40MP0000372_irregular_coat_pigmentation1.25165992
41MP0005408_hypopigmentation1.24859572
42MP0005501_abnormal_skin_physiology1.24594857
43MP0000049_abnormal_middle_ear1.24030037
44MP0003786_premature_aging1.22808360
45MP0001879_abnormal_lymphatic_vessel1.19279303
46MP0008789_abnormal_olfactory_epithelium1.19014576
47MP0009697_abnormal_copulation1.17013835
48MP0005171_absent_coat_pigmentation1.15665784
49MP0003718_maternal_effect1.12399524
50MP0002108_abnormal_muscle_morphology1.12358803
51MP0003315_abnormal_perineum_morphology1.09017053
52MP0005595_abnormal_vascular_smooth1.07543741
53MP0005165_increased_susceptibility_to1.05898050
54MP0010771_integument_phenotype1.04708049
55MP0005390_skeleton_phenotype1.04469955
56MP0000627_abnormal_mammary_gland1.03453209
57MP0000163_abnormal_cartilage_morphology1.03263287
58MP0005451_abnormal_body_composition1.02818197
59MP0009840_abnormal_foam_cell0.99736561
60MP0008007_abnormal_cellular_replicative0.98821049
61MP0000566_synostosis0.96240900
62MP0001216_abnormal_epidermal_layer0.94975748
63MP0003111_abnormal_nucleus_morphology0.93631238
64MP0002098_abnormal_vibrissa_morphology0.93002341
65MP0002938_white_spotting0.92258021
66MP0000858_altered_metastatic_potential0.92017466
67MP0005164_abnormal_response_to0.91117724
68MP0000681_abnormal_thyroid_gland0.89987390
69MP0005360_urolithiasis0.89390712
70MP0010352_gastrointestinal_tract_polyps0.88545118
71MP0003385_abnormal_body_wall0.87240799
72MP0002282_abnormal_trachea_morphology0.86799782
73MP0010030_abnormal_orbit_morphology0.86286185
74MP0003638_abnormal_response/metabolism_0.85975891
75MP0000462_abnormal_digestive_system0.85697323
76MP0006292_abnormal_olfactory_placode0.84172406
77MP0003091_abnormal_cell_migration0.84044941
78MP0000537_abnormal_urethra_morphology0.83748131
79MP0006054_spinal_hemorrhage0.83690061
80MP0006072_abnormal_retinal_apoptosis0.82138744
81MP0002295_abnormal_pulmonary_circulatio0.80703980
82MP0001727_abnormal_embryo_implantation0.80364018
83MP0005623_abnormal_meninges_morphology0.79530313
84MP0001348_abnormal_lacrimal_gland0.79237982
85MP0000733_abnormal_muscle_development0.77361349
86MP0000350_abnormal_cell_proliferation0.77189881
87MP0006036_abnormal_mitochondrial_physio0.75856024
88MP0003448_altered_tumor_morphology0.75848675
89MP0002896_abnormal_bone_mineralization0.75082563
90MP0003077_abnormal_cell_cycle0.72147000
91MP0010094_abnormal_chromosome_stability0.68653201
92MP0005395_other_phenotype0.68450824
93MP0003795_abnormal_bone_structure0.67968232
94MP0000749_muscle_degeneration0.65682063
95MP0000490_abnormal_crypts_of0.63443258
96MP0002111_abnormal_tail_morphology0.62767087
97MP0000477_abnormal_intestine_morphology0.61489366
98MP0002234_abnormal_pharynx_morphology0.61079282
99MP0001905_abnormal_dopamine_level0.60951969
100MP0002113_abnormal_skeleton_development0.59236132

Predicted human phenotypes

RankGene SetZ-score
1Ankle contracture (HP:0006466)4.73444376
2Follicular hyperkeratosis (HP:0007502)4.52662695
3Acute necrotizing encephalopathy (HP:0006965)4.25549719
4Aplastic anemia (HP:0001915)4.21198470
5Premature rupture of membranes (HP:0001788)4.14875863
6Protrusio acetabuli (HP:0003179)4.12503561
7Renal Fanconi syndrome (HP:0001994)4.00875410
8Abnormal mitochondria in muscle tissue (HP:0008316)3.98856528
9Oral leukoplakia (HP:0002745)3.57137151
10Mitochondrial inheritance (HP:0001427)3.55937774
11Increased hepatocellular lipid droplets (HP:0006565)3.46487286
12Acute encephalopathy (HP:0006846)3.42333195
13Abnormal number of erythroid precursors (HP:0012131)3.39628041
14Type 1 muscle fiber predominance (HP:0003803)3.22945849
15Abnormality of placental membranes (HP:0011409)3.16374393
16Amniotic constriction ring (HP:0009775)3.16374393
17Abnormality of cells of the erythroid lineage (HP:0012130)3.16268324
18Progressive macrocephaly (HP:0004481)3.15911031
19Slender build (HP:0001533)3.14361700
20Lipid accumulation in hepatocytes (HP:0006561)3.13917562
21Rough bone trabeculation (HP:0100670)3.08792773
22Increased CSF lactate (HP:0002490)3.02759076
23Hepatocellular necrosis (HP:0001404)2.94592046
24Abnormality of dentin (HP:0010299)2.94287726
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.93865756
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.93865756
27Degeneration of anterior horn cells (HP:0002398)2.83346584
28Abnormality of the anterior horn cell (HP:0006802)2.83346584
29Atrophic scars (HP:0001075)2.81811619
30Neonatal short-limb short stature (HP:0008921)2.80577247
31Fragile skin (HP:0001030)2.77817117
32Cerebral edema (HP:0002181)2.71501683
33Spinal rigidity (HP:0003306)2.70526647
34Sparse eyelashes (HP:0000653)2.68957497
35Increased intramyocellular lipid droplets (HP:0012240)2.66046351
36Nasolacrimal duct obstruction (HP:0000579)2.61304233
37Generalized amyotrophy (HP:0003700)2.55752257
38Breech presentation (HP:0001623)2.47630334
39Achilles tendon contracture (HP:0001771)2.47238503
40Partial duplication of the phalanx of hand (HP:0009999)2.46894870
41Hepatic necrosis (HP:0002605)2.46157390
42Exertional dyspnea (HP:0002875)2.42929652
43Trismus (HP:0000211)2.40955974
44Respiratory failure (HP:0002878)2.40310033
45Vertebral compression fractures (HP:0002953)2.35253486
46Congenital, generalized hypertrichosis (HP:0004540)2.33827460
47Axonal loss (HP:0003447)2.32220064
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.31470724
49Type I transferrin isoform profile (HP:0003642)2.30437262
50Genu recurvatum (HP:0002816)2.29898130
51Macrocytic anemia (HP:0001972)2.29376200
52Increased muscle lipid content (HP:0009058)2.29030038
53Abnormal trabecular bone morphology (HP:0100671)2.27943616
54Mildly elevated creatine phosphokinase (HP:0008180)2.25731379
55Aortic dissection (HP:0002647)2.25020642
56Broad metatarsal (HP:0001783)2.24256735
57Abnormality of renal resorption (HP:0011038)2.23665014
58Selective tooth agenesis (HP:0001592)2.20591367
59Reduced antithrombin III activity (HP:0001976)2.19393468
60Generalized aminoaciduria (HP:0002909)2.15059336
61Intrahepatic cholestasis (HP:0001406)2.12078454
62Abnormality of the Achilles tendon (HP:0005109)2.09836695
63Vascular tortuosity (HP:0004948)2.08802722
64Elbow flexion contracture (HP:0002987)2.06403305
65Bladder diverticulum (HP:0000015)2.05801304
66Partial duplication of thumb phalanx (HP:0009944)2.03900933
67Fragile nails (HP:0001808)1.99604819
68Congenital ichthyosiform erythroderma (HP:0007431)1.99321954
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98996159
70Abnormality of the costochondral junction (HP:0000919)1.97028287
71Abnormality of skeletal muscle fiber size (HP:0012084)1.94434675
72Joint stiffness (HP:0001387)1.92744372
73Spinal cord compression (HP:0002176)1.92396896
74Abnormalities of placenta or umbilical cord (HP:0001194)1.91868232
75Microretrognathia (HP:0000308)1.90794896
76Soft skin (HP:0000977)1.90165505
77Nonimmune hydrops fetalis (HP:0001790)1.90121679
78Redundant skin (HP:0001582)1.88583702
79Lactic acidosis (HP:0003128)1.88475513
80Abnormality of the phalanges of the hallux (HP:0010057)1.84597721
81Abnormality of the lacrimal duct (HP:0011481)1.84160013
82Exercise intolerance (HP:0003546)1.83196377
83Abnormality of the nasolacrimal system (HP:0000614)1.82660020
84Shallow orbits (HP:0000586)1.80478486
85Symptomatic seizures (HP:0011145)1.77521319
86Increased variability in muscle fiber diameter (HP:0003557)1.76963515
87Opisthotonus (HP:0002179)1.76327042
88Reticulocytopenia (HP:0001896)1.75378505
89Abnormal delivery (HP:0001787)1.74982027
90Abnormality of the distal phalanges of the toes (HP:0010182)1.74547383
91Blue sclerae (HP:0000592)1.72794749
92Recurrent corneal erosions (HP:0000495)1.69558310
93Nail dystrophy (HP:0008404)1.68757648
94Onycholysis (HP:0001806)1.67825549
95Pancytopenia (HP:0001876)1.66737605
96Coxa vara (HP:0002812)1.66399624
97Dicarboxylic aciduria (HP:0003215)1.65954398
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.65954398
99Wrist flexion contracture (HP:0001239)1.65290435
100Single umbilical artery (HP:0001195)1.65118629

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.33901026
2NME23.66129859
3EPHA23.65141273
4PBK3.30943993
5TESK13.28251271
6MAP3K122.76676191
7BUB12.67753821
8MST1R2.64922819
9MST42.61974039
10TESK22.51184156
11MYLK2.46257833
12EPHB22.33295961
13PAK42.31903807
14SCYL22.30503688
15LIMK12.25773766
16LATS21.93426774
17KDR1.84515192
18ABL21.75784699
19STK161.70348607
20PRKG21.68916883
21LMTK21.67100533
22TAOK21.62633513
23FLT31.59748901
24NME11.57598850
25PDGFRA1.51423225
26KIT1.49550998
27RIPK11.45154522
28PIM21.40467092
29BCKDK1.30350697
30DDR21.30229311
31CDK81.28410758
32VRK11.23924743
33MET1.22813380
34ERN11.20115441
35WEE11.15887280
36IRAK31.13183622
37CDC71.10946005
38TTK1.07883399
39PTK21.03956607
40MAP4K21.01500028
41NEK10.95529664
42PAK20.95375741
43DYRK30.94686529
44EIF2AK10.92971864
45ERBB40.89677537
46AURKB0.89051753
47MAP3K110.88844714
48NTRK10.83989165
49CLK10.83351346
50BCR0.81777364
51ILK0.81075336
52MAPKAPK30.80409968
53SRPK10.75037639
54PRKD20.72969689
55MAP2K70.70151640
56MAP3K30.67479065
57GRK10.67042158
58ARAF0.63990377
59PLK10.63760150
60CDK70.63050409
61PAK10.60555754
62DYRK20.59673555
63AURKA0.59662200
64MOS0.58303622
65CSNK2A10.57429063
66PDK20.54784844
67TGFBR20.54394535
68DAPK30.53591388
69NEK20.51118033
70ADRBK20.45659802
71CSNK2A20.45309468
72CDK60.44784745
73CAMK2D0.44315369
74PTK60.40846953
75LATS10.40221285
76NEK90.38923387
77PNCK0.38516892
78CHEK20.37804169
79LRRK20.37405233
80MAP3K60.37221931
81MATK0.36957761
82TBK10.36382841
83PRKCI0.36037197
84SIK10.34736558
85CSNK1A10.34025102
86ADRBK10.33526799
87MUSK0.32944054
88CDK11A0.32232673
89STK38L0.31180887
90PIK3CA0.30348620
91CDK140.29425510
92ZAK0.29121576
93RPS6KA40.28896629
94STK40.28132943
95DAPK10.27438594
96CDK150.26622821
97CSF1R0.26454852
98WNK40.25529078
99TAOK10.25311483
100GSK3A0.24584804

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.47844375
2Oxidative phosphorylation_Homo sapiens_hsa001904.32552236
3Ribosome_Homo sapiens_hsa030104.01071055
4Parkinsons disease_Homo sapiens_hsa050123.68602858
5Protein export_Homo sapiens_hsa030603.27289065
6RNA polymerase_Homo sapiens_hsa030202.92150224
7Alzheimers disease_Homo sapiens_hsa050102.88815196
8DNA replication_Homo sapiens_hsa030302.71467882
9Huntingtons disease_Homo sapiens_hsa050162.62923546
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.55881215
11Sulfur relay system_Homo sapiens_hsa041222.15966597
12Sulfur metabolism_Homo sapiens_hsa009202.08442086
13Pyrimidine metabolism_Homo sapiens_hsa002402.08084249
14Spliceosome_Homo sapiens_hsa030402.02551011
15Folate biosynthesis_Homo sapiens_hsa007901.99576640
16Mismatch repair_Homo sapiens_hsa034301.98472961
17Cardiac muscle contraction_Homo sapiens_hsa042601.93517379
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85784006
19Nucleotide excision repair_Homo sapiens_hsa034201.83875868
20Glutathione metabolism_Homo sapiens_hsa004801.69965366
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62749906
22Base excision repair_Homo sapiens_hsa034101.60787277
23One carbon pool by folate_Homo sapiens_hsa006701.56573702
24Homologous recombination_Homo sapiens_hsa034401.47867274
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42932143
26Vitamin B6 metabolism_Homo sapiens_hsa007501.40449173
27Nitrogen metabolism_Homo sapiens_hsa009101.37019368
28Pyruvate metabolism_Homo sapiens_hsa006201.35589146
29ECM-receptor interaction_Homo sapiens_hsa045121.33634822
30Purine metabolism_Homo sapiens_hsa002301.11203594
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02197642
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01267902
33Cyanoamino acid metabolism_Homo sapiens_hsa004600.98011791
34Basal transcription factors_Homo sapiens_hsa030220.94048391
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89093561
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88291703
37Cysteine and methionine metabolism_Homo sapiens_hsa002700.84847821
38Tyrosine metabolism_Homo sapiens_hsa003500.84479724
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81988058
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81820512
41N-Glycan biosynthesis_Homo sapiens_hsa005100.81440760
42RNA transport_Homo sapiens_hsa030130.79296507
43Metabolic pathways_Homo sapiens_hsa011000.76699826
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75329161
45Protein digestion and absorption_Homo sapiens_hsa049740.72728934
46RNA degradation_Homo sapiens_hsa030180.72363286
47Mineral absorption_Homo sapiens_hsa049780.70507386
48Vibrio cholerae infection_Homo sapiens_hsa051100.69877225
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67769215
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67679299
51Chemical carcinogenesis_Homo sapiens_hsa052040.65667167
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.65026969
53Cell cycle_Homo sapiens_hsa041100.64719991
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.61973496
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60968335
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60592193
57Fructose and mannose metabolism_Homo sapiens_hsa000510.58732091
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57664263
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.56681655
60Propanoate metabolism_Homo sapiens_hsa006400.54784116
61Carbon metabolism_Homo sapiens_hsa012000.51649270
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50490811
63Shigellosis_Homo sapiens_hsa051310.49301142
64Small cell lung cancer_Homo sapiens_hsa052220.48695709
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48633156
66Fanconi anemia pathway_Homo sapiens_hsa034600.47949135
67Selenocompound metabolism_Homo sapiens_hsa004500.47394710
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44307442
69Retinol metabolism_Homo sapiens_hsa008300.43114817
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42639547
71Fatty acid elongation_Homo sapiens_hsa000620.42566397
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42283935
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42087512
74Fatty acid degradation_Homo sapiens_hsa000710.40660355
75Renin-angiotensin system_Homo sapiens_hsa046140.40636820
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37460718
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37338495
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36917999
79Arachidonic acid metabolism_Homo sapiens_hsa005900.35237659
80Focal adhesion_Homo sapiens_hsa045100.35007217
81Epstein-Barr virus infection_Homo sapiens_hsa051690.33262941
82Prion diseases_Homo sapiens_hsa050200.31461733
83Tryptophan metabolism_Homo sapiens_hsa003800.30152668
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29903777
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29357312
86Peroxisome_Homo sapiens_hsa041460.29270404
87Galactose metabolism_Homo sapiens_hsa000520.26924984
88Biosynthesis of amino acids_Homo sapiens_hsa012300.26686573
89Pertussis_Homo sapiens_hsa051330.25947148
90p53 signaling pathway_Homo sapiens_hsa041150.24446526
91Phototransduction_Homo sapiens_hsa047440.24276590
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23897175
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22989258
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22850150
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21267979
96Steroid biosynthesis_Homo sapiens_hsa001000.19244860
97Other glycan degradation_Homo sapiens_hsa005110.18207825
98Caffeine metabolism_Homo sapiens_hsa002320.17150261
99Complement and coagulation cascades_Homo sapiens_hsa046100.16305682
100Pentose phosphate pathway_Homo sapiens_hsa000300.14319963

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »