ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.75787832
2	fucose catabolic process (GO:0019317)	4.45414547
3	L-fucose metabolic process (GO:0042354)	4.45414547
4	L-fucose catabolic process (GO:0042355)	4.45414547
5	cellular response to interleukin-15 (GO:0071350)	4.19554743
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.19401258
7	protein-cofactor linkage (GO:0018065)	4.18547391
8	detection of light stimulus involved in sensory perception (GO:0050962)	4.17895526
9	detection of light stimulus involved in visual perception (GO:0050908)	4.17895526
10	tolerance induction (GO:0002507)	3.94871403
11	base-excision repair, AP site formation (GO:0006285)	3.85534976
12	interferon-gamma production (GO:0032609)	3.79393901
13	regulation of protein kinase A signaling (GO:0010738)	3.77929061
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.77778927
15	ATP synthesis coupled proton transport (GO:0015986)	3.77778927
16	positive regulation of humoral immune response (GO:0002922)	3.52107938
17	cellular response to ATP (GO:0071318)	3.51733860
18	preassembly of GPI anchor in ER membrane (GO:0016254)	3.47863690
19	negative regulation of cell killing (GO:0031342)	3.47518047
20	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	3.47518047
21	positive regulation of defense response to virus by host (GO:0002230)	3.32515986
22	regulation of T cell receptor signaling pathway (GO:0050856)	3.28055865
23	piRNA metabolic process (GO:0034587)	3.28032448
24	cAMP catabolic process (GO:0006198)	3.26894069
25	protein neddylation (GO:0045116)	3.26720126
26	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.25714662
27	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.24979557
28	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.19502536
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.16296934
30	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.16296934
31	gonadal mesoderm development (GO:0007506)	3.15361795
32	mast cell activation (GO:0045576)	3.14618821
33	lymph node development (GO:0048535)	3.08173655
34	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.05210480
35	negative regulation of T cell mediated immunity (GO:0002710)	3.03257101
36	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.03000762
37	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.99950997
38	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.98001696
39	platelet dense granule organization (GO:0060155)	2.97587414
40	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.97178560
41	one-carbon compound transport (GO:0019755)	2.95973417
42	cyclic nucleotide catabolic process (GO:0009214)	2.95703413
43	response to interleukin-15 (GO:0070672)	2.94944798
44	regulation of regulatory T cell differentiation (GO:0045589)	2.94862842
45	peptidyl-histidine modification (GO:0018202)	2.91835306
46	regulation of T cell mediated cytotoxicity (GO:0001914)	2.91608880
47	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.88896425
48	regulation of translation, ncRNA-mediated (GO:0045974)	2.88896425
49	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.88896425
50	regulation of gamma-delta T cell differentiation (GO:0045586)	2.86086198
51	pseudouridine synthesis (GO:0001522)	2.86041912
52	adenosine metabolic process (GO:0046085)	2.85155000
53	cellular response to exogenous dsRNA (GO:0071360)	2.84199613
54	GTP biosynthetic process (GO:0006183)	2.83981783
55	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.83239276
56	DNA methylation involved in gamete generation (GO:0043046)	2.82758121
57	tRNA processing (GO:0008033)	2.82654391
58	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.80527382
59	adaptation of signaling pathway (GO:0023058)	2.79903616
60	kynurenine metabolic process (GO:0070189)	2.77800177
61	mannosylation (GO:0097502)	2.77020935
62	respiratory electron transport chain (GO:0022904)	2.76524322
63	regulation of hypersensitivity (GO:0002883)	2.76393536
64	behavioral response to nicotine (GO:0035095)	2.75040537
65	magnesium ion transport (GO:0015693)	2.74504411
66	electron transport chain (GO:0022900)	2.73923339
67	protein peptidyl-prolyl isomerization (GO:0000413)	2.73757998
68	negative T cell selection (GO:0043383)	2.72879762
69	protein complex biogenesis (GO:0070271)	2.69949686
70	indolalkylamine metabolic process (GO:0006586)	2.69728784
71	negative regulation of telomere maintenance (GO:0032205)	2.69627214
72	positive regulation of T-helper 1 type immune response (GO:0002827)	2.66515037
73	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.65557127
74	maturation of 5.8S rRNA (GO:0000460)	2.63681893
75	hydrogen ion transmembrane transport (GO:1902600)	2.63009491
76	NADH dehydrogenase complex assembly (GO:0010257)	2.62000669
77	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.62000669
78	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.62000669
79	proton transport (GO:0015992)	2.61909648
80	respiratory chain complex IV assembly (GO:0008535)	2.60972865
81	hydrogen transport (GO:0006818)	2.60590214
82	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.60442575
83	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.59846889
84	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.57320786
85	positive regulation of antigen processing and presentation (GO:0002579)	2.56220943
86	establishment of protein localization to Golgi (GO:0072600)	2.55908194
87	GPI anchor metabolic process (GO:0006505)	2.55559168
88	mast cell degranulation (GO:0043303)	2.55124080
89	mast cell activation involved in immune response (GO:0002279)	2.55124080
90	cytidine deamination (GO:0009972)	2.52419065
91	cytidine metabolic process (GO:0046087)	2.52419065
92	cytidine catabolic process (GO:0006216)	2.52419065
93	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.52308677
94	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.51330549
95	inositol phosphate dephosphorylation (GO:0046855)	2.51330549
96	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.51299020
97	T cell differentiation involved in immune response (GO:0002292)	2.50520160
98	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.50520160
99	alpha-beta T cell activation involved in immune response (GO:0002287)	2.50520160
100	regulation of gamma-delta T cell activation (GO:0046643)	2.50130273

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.39394329
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.03104549
3	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.96849483
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.89102884
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.82367876
6	VDR_22108803_ChIP-Seq_LS180_Human	2.81715349
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.61336529
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.46439470
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.45320439
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.36033019
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.30727603
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.28980047
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.25264324
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.22517485
15	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.12965665
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.07909227
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.05804664
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.83315288
19	GATA3_26560356_Chip-Seq_TH2_Human	1.81884891
20	GBX2_23144817_ChIP-Seq_PC3_Human	1.81040452
21	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.80281504
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76601214
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.75585646
24	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.72707449
25	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.70114204
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.67165318
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.66582186
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.64424914
29	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.62576821
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.62207825
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.58040379
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.57285382
33	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56964285
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.55844533
35	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.53942707
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.51869140
37	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.49010267
38	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.46815679
39	MYC_19829295_ChIP-Seq_ESCs_Human	1.46062533
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43804983
41	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.41239606
42	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.40516182
43	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.40204718
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.39452252
45	RUNX_20019798_ChIP-Seq_JUKART_Human	1.38322153
46	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.37751637
47	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.37549846
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36227184
49	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.33617338
50	MYB_26560356_Chip-Seq_TH2_Human	1.28761980
51	NCOR_22424771_ChIP-Seq_293T_Human	1.27575794
52	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.27259070
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.23691802
54	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.23530899
55	P300_19829295_ChIP-Seq_ESCs_Human	1.22184059
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21657548
57	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.20621941
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19785585
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19498963
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17665696
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17665696
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15776188
63	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14907401
64	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14124658
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12062476
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11949020
67	AR_21572438_ChIP-Seq_LNCaP_Human	1.11257465
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11236193
69	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10086154
70	STAT1_20625510_ChIP-Seq_HELA_Human	1.09153323
71	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08459811
72	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.08049590
73	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.07217138
74	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.06861484
75	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.06791494
76	CBP_20019798_ChIP-Seq_JUKART_Human	1.06494348
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06494348
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06240611
79	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.05481675
80	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04025033
81	GABP_19822575_ChIP-Seq_HepG2_Human	1.04014491
82	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03048728
83	GATA3_27048872_Chip-Seq_THYMUS_Human	1.02960997
84	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02679125
85	TCF4_22108803_ChIP-Seq_LS180_Human	1.02050476
86	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01032647
87	OCT4_20526341_ChIP-Seq_ESCs_Human	1.00651971
88	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99835327
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99331316
90	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.99049774
91	TAF15_26573619_Chip-Seq_HEK293_Human	0.98347292
92	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.98295857
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.98219411
94	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.97907884
95	EWS_26573619_Chip-Seq_HEK293_Human	0.97469847
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97420167
97	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.96150611
98	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95883202
99	AR_20517297_ChIP-Seq_VCAP_Human	0.94896549
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.94253134

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.41784272
2	MP0005671_abnormal_response_to	3.22448325
3	MP0003806_abnormal_nucleotide_metabolis	2.82012682
4	MP0008872_abnormal_physiological_respon	2.41458734
5	MP0001835_abnormal_antigen_presentation	2.25453191
6	MP0003787_abnormal_imprinting	2.22514231
7	MP0002837_dystrophic_cardiac_calcinosis	2.14813069
8	MP0008875_abnormal_xenobiotic_pharmacok	2.10820654
9	MP0003436_decreased_susceptibility_to	2.10475505
10	MP0001501_abnormal_sleep_pattern	2.07898035
11	MP0005551_abnormal_eye_electrophysiolog	2.05576871
12	MP0001800_abnormal_humoral_immune	2.03982413
13	MP0000685_abnormal_immune_system	2.03787756
14	MP0001986_abnormal_taste_sensitivity	1.98592729
15	MP0008995_early_reproductive_senescence	1.97520931
16	MP0009785_altered_susceptibility_to	1.96631966
17	MP0003763_abnormal_thymus_physiology	1.90471592
18	MP0002876_abnormal_thyroid_physiology	1.89824907
19	MP0005000_abnormal_immune_tolerance	1.87939179
20	MP0005379_endocrine/exocrine_gland_phen	1.85121928
21	MP0003195_calcinosis	1.84687439
22	MP0006072_abnormal_retinal_apoptosis	1.84447778
23	MP0002138_abnormal_hepatobiliary_system	1.74527571
24	MP0002723_abnormal_immune_serum	1.72446925
25	MP0009333_abnormal_splenocyte_physiolog	1.69533488
26	MP0002148_abnormal_hypersensitivity_rea	1.69481650
27	MP0005645_abnormal_hypothalamus_physiol	1.65744875
28	MP0003786_premature_aging	1.64300321
29	MP0002163_abnormal_gland_morphology	1.59759592
30	MP0001529_abnormal_vocalization	1.56654539
31	MP0002452_abnormal_antigen_presenting	1.55679686
32	MP0009764_decreased_sensitivity_to	1.53410063
33	MP0008775_abnormal_heart_ventricle	1.53168536
34	MP0003252_abnormal_bile_duct	1.49627646
35	MP0002420_abnormal_adaptive_immunity	1.48499121
36	MP0001819_abnormal_immune_cell	1.48414259
37	MP0005646_abnormal_pituitary_gland	1.48324767
38	MP0004043_abnormal_pH_regulation	1.44715554
39	MP0005387_immune_system_phenotype	1.42222396
40	MP0001790_abnormal_immune_system	1.42222396
41	MP0001765_abnormal_ion_homeostasis	1.37159863
42	MP0006036_abnormal_mitochondrial_physio	1.36866786
43	MP0001727_abnormal_embryo_implantation	1.35099049
44	MP0005377_hearing/vestibular/ear_phenot	1.33503295
45	MP0003878_abnormal_ear_physiology	1.33503295
46	MP0005075_abnormal_melanosome_morpholog	1.32440272
47	MP0000427_abnormal_hair_cycle	1.32329355
48	MP0003122_maternal_imprinting	1.30393653
49	MP0003011_delayed_dark_adaptation	1.28506579
50	MP0009046_muscle_twitch	1.26059343
51	MP0009745_abnormal_behavioral_response	1.23574284
52	MP0005025_abnormal_response_to	1.23428004
53	MP0005332_abnormal_amino_acid	1.22077897
54	MP0002102_abnormal_ear_morphology	1.21658553
55	MP0000372_irregular_coat_pigmentation	1.21465904
56	MP0002693_abnormal_pancreas_physiology	1.20470415
57	MP0002272_abnormal_nervous_system	1.19653890
58	MP0005253_abnormal_eye_physiology	1.19611091
59	MP0003866_abnormal_defecation	1.18353287
60	MP0004484_altered_response_of	1.16742392
61	MP0005365_abnormal_bile_salt	1.16178570
62	MP0004145_abnormal_muscle_electrophysio	1.15586352
63	MP0001845_abnormal_inflammatory_respons	1.15079861
64	MP0000716_abnormal_immune_system	1.13158180
65	MP0001968_abnormal_touch/_nociception	1.12839937
66	MP0002405_respiratory_system_inflammati	1.07971149
67	MP0000689_abnormal_spleen_morphology	1.07003827
68	MP0003724_increased_susceptibility_to	1.06499057
69	MP0003121_genomic_imprinting	1.06120713
70	MP0004142_abnormal_muscle_tone	1.04162129
71	MP0001873_stomach_inflammation	1.02916360
72	MP0002419_abnormal_innate_immunity	1.02043290
73	MP0002653_abnormal_ependyma_morphology	1.01880385
74	MP0000703_abnormal_thymus_morphology	1.00482634
75	MP0010155_abnormal_intestine_physiology	0.99529268
76	MP0004885_abnormal_endolymph	0.98801371
77	MP0002398_abnormal_bone_marrow	0.98489603
78	MP0003879_abnormal_hair_cell	0.96826599
79	MP0003186_abnormal_redox_activity	0.96507509
80	MP0001919_abnormal_reproductive_system	0.96213430
81	MP0003638_abnormal_response/metabolism_	0.95979470
82	MP0005636_abnormal_mineral_homeostasis	0.92530450
83	MP0001533_abnormal_skeleton_physiology	0.88711234
84	MP0004147_increased_porphyrin_level	0.88294693
85	MP0002722_abnormal_immune_system	0.87832266
86	MP0001905_abnormal_dopamine_level	0.87533739
87	MP0004381_abnormal_hair_follicle	0.87023823
88	MP0004742_abnormal_vestibular_system	0.86682160
89	MP0004924_abnormal_behavior	0.85453903
90	MP0005386_behavior/neurological_phenoty	0.85453903
91	MP0002429_abnormal_blood_cell	0.85289198
92	MP0003172_abnormal_lysosome_physiology	0.83993091
93	MP0002638_abnormal_pupillary_reflex	0.82979271
94	MP0005165_increased_susceptibility_to	0.82696109
95	MP0005389_reproductive_system_phenotype	0.80679516
96	MP0002572_abnormal_emotion/affect_behav	0.80424773
97	MP0010386_abnormal_urinary_bladder	0.80301129
98	MP0002166_altered_tumor_susceptibility	0.79682993
99	MP0002733_abnormal_thermal_nociception	0.77802971
100	MP0005085_abnormal_gallbladder_physiolo	0.76083997

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	6.05951706
2	Abnormal rod and cone electroretinograms (HP:0008323)	4.77632187
3	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.75256960
4	Hypoplasia of the fovea (HP:0007750)	4.75256960
5	Elevated erythrocyte sedimentation rate (HP:0003565)	4.24291188
6	Abnormality of the fovea (HP:0000493)	4.08803315
7	Abnormality of macular pigmentation (HP:0008002)	3.76363134
8	Severe visual impairment (HP:0001141)	3.53128972
9	Albinism (HP:0001022)	3.44423108
10	Agitation (HP:0000713)	3.37334463
11	Renal cortical cysts (HP:0000803)	3.28228230
12	Type II lissencephaly (HP:0007260)	3.27031906
13	Severe combined immunodeficiency (HP:0004430)	3.25209971
14	IgG deficiency (HP:0004315)	3.21503678
15	Acute necrotizing encephalopathy (HP:0006965)	3.15864069
16	Aplasia/Hypoplasia of the macula (HP:0008059)	2.93841416
17	Stomatitis (HP:0010280)	2.92934014
18	Central scotoma (HP:0000603)	2.92815100
19	Hepatic necrosis (HP:0002605)	2.81278984
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.79528801
21	Abnormality of the renal cortex (HP:0011035)	2.77986799
22	Congenital, generalized hypertrichosis (HP:0004540)	2.77836968
23	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.76646818
24	Generalized aminoaciduria (HP:0002909)	2.74135144
25	Mitochondrial inheritance (HP:0001427)	2.73946777
26	3-Methylglutaconic aciduria (HP:0003535)	2.73594669
27	Increased CSF lactate (HP:0002490)	2.69185444
28	Molar tooth sign on MRI (HP:0002419)	2.68099020
29	Abnormality of midbrain morphology (HP:0002418)	2.68099020
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.65884413
31	Opisthotonus (HP:0002179)	2.58672227
32	Acute encephalopathy (HP:0006846)	2.58355330
33	Progressive macrocephaly (HP:0004481)	2.57467443
34	Progressive microcephaly (HP:0000253)	2.55407645
35	Chronic diarrhea (HP:0002028)	2.51959161
36	Inability to walk (HP:0002540)	2.50729415
37	Hepatocellular necrosis (HP:0001404)	2.48246342
38	Abnormal number of erythroid precursors (HP:0012131)	2.47717492
39	Hypoproteinemia (HP:0003075)	2.43076836
40	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.43038236
41	Combined immunodeficiency (HP:0005387)	2.42642532
42	Thyroiditis (HP:0100646)	2.41795453
43	Nephronophthisis (HP:0000090)	2.41505536
44	Retinal dysplasia (HP:0007973)	2.41504638
45	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.31924576
46	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.31924576
47	Optic disc pallor (HP:0000543)	2.30279297
48	Cerebral hypomyelination (HP:0006808)	2.27913322
49	Abnormality of eosinophils (HP:0001879)	2.26716128
50	Hypoalbuminemia (HP:0003073)	2.26278062
51	Abnormal albumin level (HP:0012116)	2.26278062
52	Attenuation of retinal blood vessels (HP:0007843)	2.25544493
53	Abolished electroretinogram (ERG) (HP:0000550)	2.17093211
54	Mesangial abnormality (HP:0001966)	2.15976954
55	Scotoma (HP:0000575)	2.08936440
56	Prostate neoplasm (HP:0100787)	2.08935140
57	Progressive inability to walk (HP:0002505)	2.05479391
58	Abnormality of T cells (HP:0002843)	2.04097436
59	Abnormal drinking behavior (HP:0030082)	2.04044815
60	Polydipsia (HP:0001959)	2.04044815
61	Abnormality of cells of the erythroid lineage (HP:0012130)	2.02400293
62	T lymphocytopenia (HP:0005403)	2.01687624
63	Generalized hypopigmentation (HP:0007513)	2.00928332
64	Myositis (HP:0100614)	1.98391338
65	Increased corneal curvature (HP:0100692)	1.98323577
66	Keratoconus (HP:0000563)	1.98323577
67	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.97819658
68	Severe muscular hypotonia (HP:0006829)	1.96656743
69	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.95441989
70	Abnormality of the prostate (HP:0008775)	1.94930205
71	Broad-based gait (HP:0002136)	1.92300386
72	Abnormality of the pons (HP:0007361)	1.90767801
73	Chronic mucocutaneous candidiasis (HP:0002728)	1.89947978
74	Recurrent cutaneous fungal infections (HP:0011370)	1.89947978
75	Abnormality of T cell number (HP:0011839)	1.89577830
76	Ketosis (HP:0001946)	1.88519851
77	Increased serum lactate (HP:0002151)	1.88395876
78	Pustule (HP:0200039)	1.88181811
79	Abnormality of B cell number (HP:0010975)	1.88045256
80	Neonatal respiratory distress (HP:0002643)	1.87817823
81	B lymphocytopenia (HP:0010976)	1.86615794
82	Lactic acidosis (HP:0003128)	1.85765261
83	Hypomagnesemia (HP:0002917)	1.82567526
84	Abnormality of the renal medulla (HP:0100957)	1.82068539
85	Hypothermia (HP:0002045)	1.81862877
86	Aplasia/hypoplasia of the uterus (HP:0008684)	1.81047312
87	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.80447188
88	Pancreatic cysts (HP:0001737)	1.80195107
89	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.78447096
90	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.78447096
91	Tubular atrophy (HP:0000092)	1.78131210
92	Abnormality of T cell physiology (HP:0011840)	1.77359893
93	Lipid accumulation in hepatocytes (HP:0006561)	1.76468105
94	Methylmalonic acidemia (HP:0002912)	1.75625776
95	Limb dystonia (HP:0002451)	1.75173176
96	Restlessness (HP:0000711)	1.74758178
97	Pachygyria (HP:0001302)	1.74314776
98	Oligomenorrhea (HP:0000876)	1.73133256
99	Tongue fasciculations (HP:0001308)	1.71426288
100	Polyuria (HP:0000103)	1.70458241

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.73446439
2	MAP4K2	4.50301851
3	VRK2	2.85462097
4	TLK1	2.79318976
5	WNK4	2.69872170
6	TAOK3	2.49848581
7	MUSK	2.46130119
8	NEK1	2.10225152
9	ADRBK2	2.10115878
10	NUAK1	2.04666049
11	FRK	2.00841060
12	PINK1	1.94450502
13	TSSK6	1.86355531
14	IKBKE	1.78289021
15	GRK6	1.72283197
16	CSNK1G3	1.67178347
17	EIF2AK3	1.64984827
18	GRK1	1.61677560
19	TESK2	1.60287928
20	CSNK1G2	1.53981229
21	IKBKB	1.49334828
22	KIT	1.47793601
23	CSNK1A1L	1.45696818
24	PHKG1	1.44508092
25	PHKG2	1.44508092
26	BCKDK	1.38108449
27	MAP3K14	1.30718132
28	GRK7	1.28943204
29	CSNK1G1	1.27987184
30	ZAK	1.22458785
31	WNK3	1.22361471
32	SCYL2	1.21202042
33	TEC	1.19354423
34	TRPM7	1.19184839
35	MAP4K1	1.14946873
36	CAMKK2	1.12105654
37	SIK2	1.11432978
38	OXSR1	1.11299716
39	MAP3K12	1.08111115
40	STK39	1.07942711
41	MAP3K11	1.07595714
42	ITK	1.04695152
43	MAP2K2	1.02458320
44	SYK	0.99454660
45	TYK2	0.92019548
46	EIF2AK2	0.90518611
47	MAPKAPK5	0.90041128
48	TBK1	0.88554320
49	MAPKAPK3	0.87964910
50	PAK3	0.87267768
51	JAK1	0.77133880
52	MAP3K13	0.76811596
53	EPHA3	0.74844844
54	PRKCQ	0.73744328
55	PTK2B	0.72395141
56	CSF1R	0.71797225
57	DAPK2	0.71649137
58	VRK1	0.70274384
59	BTK	0.69041836
60	DAPK1	0.68257065
61	ALK	0.67796963
62	LCK	0.67122868
63	ADRBK1	0.66485820
64	TAF1	0.65203395
65	JAK3	0.64536504
66	GRK5	0.62012525
67	MAP2K6	0.60378854
68	HCK	0.59190295
69	PLK2	0.59059049
70	LYN	0.55801171
71	ATR	0.55626949
72	MYLK	0.53616126
73	LIMK1	0.53543005
74	CCNB1	0.53446086
75	NLK	0.53411617
76	STK38L	0.49177344
77	ILK	0.47615395
78	MST4	0.46436774
79	MAP3K4	0.45513602
80	CAMK2D	0.45385817
81	ERBB3	0.44216714
82	CHUK	0.43922319
83	ARAF	0.41983626
84	IGF1R	0.41042105
85	FES	0.41037121
86	INSRR	0.41009998
87	CSNK1A1	0.40496554
88	MAPK13	0.40056499
89	HIPK2	0.39543718
90	PASK	0.39329292
91	PRKCE	0.38219642
92	TGFBR2	0.36804089
93	ZAP70	0.36679364
94	EPHA4	0.36092197
95	NTRK3	0.35811654
96	MATK	0.35713605
97	ABL2	0.34332323
98	PRKACA	0.33954987
99	MARK3	0.32119484
100	CSNK1D	0.31825251

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.35231624
2	Sulfur metabolism_Homo sapiens_hsa00920	2.80049132
3	Proteasome_Homo sapiens_hsa03050	2.72379000
4	Parkinsons disease_Homo sapiens_hsa05012	2.51718154
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.39772409
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.29421327
7	RNA polymerase_Homo sapiens_hsa03020	2.27078490
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.15374512
9	Alzheimers disease_Homo sapiens_hsa05010	2.14929747
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.06304366
11	Protein export_Homo sapiens_hsa03060	1.97369628
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.97052706
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.95583071
14	RNA degradation_Homo sapiens_hsa03018	1.83148997
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.76482053
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74886365
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.68609957
18	One carbon pool by folate_Homo sapiens_hsa00670	1.57196303
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.55653925
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.54184383
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.54180728
22	Huntingtons disease_Homo sapiens_hsa05016	1.53788167
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.53442164
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.53165552
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.51695123
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.46079939
27	Allograft rejection_Homo sapiens_hsa05330	1.42849901
28	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.41859335
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.40193673
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.38381865
31	Phototransduction_Homo sapiens_hsa04744	1.38114125
32	Caffeine metabolism_Homo sapiens_hsa00232	1.36085780
33	Asthma_Homo sapiens_hsa05310	1.33922247
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23275441
35	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.22483688
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.21907053
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.20364376
38	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.19692442
39	Morphine addiction_Homo sapiens_hsa05032	1.18881512
40	Antigen processing and presentation_Homo sapiens_hsa04612	1.16642360
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.14586926
42	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.09114175
43	Salivary secretion_Homo sapiens_hsa04970	1.08765630
44	Renin secretion_Homo sapiens_hsa04924	1.07037365
45	Insulin secretion_Homo sapiens_hsa04911	1.06943292
46	GABAergic synapse_Homo sapiens_hsa04727	1.04933573
47	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.01063054
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99517693
49	Regulation of autophagy_Homo sapiens_hsa04140	0.97024066
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96917103
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.96796371
52	Purine metabolism_Homo sapiens_hsa00230	0.94933026
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.92998966
54	Butanoate metabolism_Homo sapiens_hsa00650	0.91724154
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.87003481
56	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.84795106
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.83405993
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81223634
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.81010964
60	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.80732936
61	Rheumatoid arthritis_Homo sapiens_hsa05323	0.79196314
62	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.77578109
63	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.76573038
64	Homologous recombination_Homo sapiens_hsa03440	0.75288154
65	Spliceosome_Homo sapiens_hsa03040	0.70735623
66	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.70647057
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.70125305
68	Peroxisome_Homo sapiens_hsa04146	0.67919577
69	Circadian rhythm_Homo sapiens_hsa04710	0.67184569
70	Propanoate metabolism_Homo sapiens_hsa00640	0.66633309
71	Sulfur relay system_Homo sapiens_hsa04122	0.65844827
72	Legionellosis_Homo sapiens_hsa05134	0.64056710
73	Serotonergic synapse_Homo sapiens_hsa04726	0.62859905
74	Circadian entrainment_Homo sapiens_hsa04713	0.62262921
75	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.61516709
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.59833221
77	Metabolic pathways_Homo sapiens_hsa01100	0.59463426
78	Folate biosynthesis_Homo sapiens_hsa00790	0.55138876
79	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.54198343
80	Mineral absorption_Homo sapiens_hsa04978	0.54196635
81	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.53874598
82	Basal transcription factors_Homo sapiens_hsa03022	0.52038377
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50188331
84	Measles_Homo sapiens_hsa05162	0.47306475
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45942049
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.45808976
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45674104
88	Olfactory transduction_Homo sapiens_hsa04740	0.45450349
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44860674
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44749178
91	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.44000161
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43316428
93	ABC transporters_Homo sapiens_hsa02010	0.42668872
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.42260696
95	Amphetamine addiction_Homo sapiens_hsa05031	0.40316326
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39134765
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39091884
98	Chemical carcinogenesis_Homo sapiens_hsa05204	0.39082646
99	Taste transduction_Homo sapiens_hsa04742	0.36682124
100	Ribosome_Homo sapiens_hsa03010	0.36351773

MINOS1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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