MINPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.38182817
2heme biosynthetic process (GO:0006783)5.07704294
3DNA deamination (GO:0045006)4.95927025
4folic acid metabolic process (GO:0046655)4.90757665
5protoporphyrinogen IX metabolic process (GO:0046501)4.79749448
6protoporphyrinogen IX biosynthetic process (GO:0006782)4.66062372
7DNA unwinding involved in DNA replication (GO:0006268)4.49623812
8DNA strand elongation involved in DNA replication (GO:0006271)4.47725693
9heme metabolic process (GO:0042168)4.43915208
10ribosomal small subunit assembly (GO:0000028)4.40770059
11lysine catabolic process (GO:0006554)4.40728491
12lysine metabolic process (GO:0006553)4.40728491
13DNA replication initiation (GO:0006270)4.38549996
14hemoglobin metabolic process (GO:0020027)4.37702524
15telomere maintenance via semi-conservative replication (GO:0032201)4.27502642
16DNA strand elongation (GO:0022616)4.20206693
17porphyrin-containing compound biosynthetic process (GO:0006779)4.19155688
18viral transcription (GO:0019083)4.13465910
19translational termination (GO:0006415)4.10036909
20pteridine-containing compound biosynthetic process (GO:0042559)3.89627782
21protein autoprocessing (GO:0016540)3.86154101
22formation of translation preinitiation complex (GO:0001731)3.85015711
23pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.83169402
24translational elongation (GO:0006414)3.82455371
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.79436695
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77918228
27proline biosynthetic process (GO:0006561)3.77243878
28DNA ligation (GO:0006266)3.76561949
29porphyrin-containing compound metabolic process (GO:0006778)3.69956268
30tetrapyrrole biosynthetic process (GO:0033014)3.62864253
31DNA replication checkpoint (GO:0000076)3.62755893
32regulation of mitochondrial translation (GO:0070129)3.62091618
33deoxyribose phosphate biosynthetic process (GO:0046385)3.61641015
342-deoxyribonucleotide biosynthetic process (GO:0009265)3.61641015
35deoxyribonucleotide biosynthetic process (GO:0009263)3.58295342
36one-carbon metabolic process (GO:0006730)3.55385644
37DNA topological change (GO:0006265)3.53017824
38maturation of SSU-rRNA (GO:0030490)3.48987985
39translational initiation (GO:0006413)3.48318959
40pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.47497868
41telomere maintenance via recombination (GO:0000722)3.47386341
42granulocyte differentiation (GO:0030851)3.45832514
43tetrahydrofolate metabolic process (GO:0046653)3.44784759
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.44220994
45IMP biosynthetic process (GO:0006188)3.44209945
46Golgi transport vesicle coating (GO:0048200)3.41441956
47COPI coating of Golgi vesicle (GO:0048205)3.41441956
48establishment of viral latency (GO:0019043)3.39500771
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.37577701
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35327487
51positive regulation of megakaryocyte differentiation (GO:0045654)3.34613518
52mitotic nuclear envelope disassembly (GO:0007077)3.34576552
53protein targeting to ER (GO:0045047)3.32726772
54cotranslational protein targeting to membrane (GO:0006613)3.32631946
55folic acid-containing compound metabolic process (GO:0006760)3.32585021
56protein maturation by protein folding (GO:0022417)3.28512067
57cysteine metabolic process (GO:0006534)3.25251589
58positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.23980422
59nucleobase biosynthetic process (GO:0046112)3.21996666
60pyrimidine nucleotide catabolic process (GO:0006244)3.21255186
61glycine metabolic process (GO:0006544)3.20406030
62definitive hemopoiesis (GO:0060216)3.19758815
63pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.19674450
64protein localization to endoplasmic reticulum (GO:0070972)3.18397197
65mitotic recombination (GO:0006312)3.17043853
66tetrapyrrole metabolic process (GO:0033013)3.16962002
67viral life cycle (GO:0019058)3.16422210
68pentose-phosphate shunt (GO:0006098)3.16059505
69nuclear pore complex assembly (GO:0051292)3.15438858
70establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15417251
71cellular protein complex disassembly (GO:0043624)3.13436479
72serine family amino acid biosynthetic process (GO:0009070)3.11968991
73nuclear envelope disassembly (GO:0051081)3.10525681
74membrane disassembly (GO:0030397)3.10525681
75IMP metabolic process (GO:0046040)3.09804568
76translesion synthesis (GO:0019985)3.05891862
77ribosome biogenesis (GO:0042254)3.05704371
78regulation of translational termination (GO:0006449)3.04825883
79pseudouridine synthesis (GO:0001522)3.04578610
80negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03347317
81proteasome assembly (GO:0043248)3.01915610
82protein localization to kinetochore (GO:0034501)3.01401795
83DNA replication-dependent nucleosome assembly (GO:0006335)3.00152173
84DNA replication-dependent nucleosome organization (GO:0034723)3.00152173
85telomere maintenance via telomere lengthening (GO:0010833)2.99476419
86erythrocyte maturation (GO:0043249)2.98169144
87mitotic chromosome condensation (GO:0007076)2.97060523
88erythrocyte development (GO:0048821)2.95006344
89pteridine-containing compound metabolic process (GO:0042558)2.94498890
90viral mRNA export from host cell nucleus (GO:0046784)2.94322871
91negative regulation of RNA splicing (GO:0033119)2.93205547
92ribosomal small subunit biogenesis (GO:0042274)2.92973492
93ribonucleoprotein complex biogenesis (GO:0022613)2.92081428
94regulation of protein heterodimerization activity (GO:0043497)2.91888016
95nucleoside salvage (GO:0043174)2.91788733
96nuclear pore organization (GO:0006999)2.90742919
97spliceosomal snRNP assembly (GO:0000387)2.88349397
98mitotic metaphase plate congression (GO:0007080)2.85708617
99DNA replication-independent nucleosome assembly (GO:0006336)2.80933653
100protein localization to chromosome, centromeric region (GO:0071459)2.80390620
101protein complex disassembly (GO:0043241)2.79264286
102mitotic sister chromatid segregation (GO:0000070)2.78972241
103ribosomal large subunit biogenesis (GO:0042273)2.78678540
104CENP-A containing nucleosome assembly (GO:0034080)2.78547646
105NADPH regeneration (GO:0006740)2.77720477
106very-low-density lipoprotein particle assembly (GO:0034379)2.75247142
107purine nucleobase biosynthetic process (GO:0009113)2.74633776
108purine ribonucleotide transport (GO:0015868)2.74092835
109oxidative phosphorylation (GO:0006119)2.73616429
110nucleotide-excision repair, DNA gap filling (GO:0006297)2.72806575
111ribosome assembly (GO:0042255)2.71991764
112translation (GO:0006412)2.71777258
113serine family amino acid metabolic process (GO:0009069)2.71447949
114chromatin remodeling at centromere (GO:0031055)2.70625628
115nucleoside diphosphate biosynthetic process (GO:0009133)2.70590339
116nucleobase-containing small molecule interconversion (GO:0015949)2.70198058
117non-recombinational repair (GO:0000726)2.69863505
118double-strand break repair via nonhomologous end joining (GO:0006303)2.69863505
119maternal placenta development (GO:0001893)2.69407676
120regulation of translational fidelity (GO:0006450)2.68808982
121sister chromatid segregation (GO:0000819)2.67803028
122regulation of double-strand break repair via homologous recombination (GO:0010569)2.67035593
123pigment biosynthetic process (GO:0046148)2.66914551
124purine-containing compound salvage (GO:0043101)2.65281189
125pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.64351806
126UMP biosynthetic process (GO:0006222)2.64351806
127pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.64351806
128UMP metabolic process (GO:0046049)2.64351806
129macromolecular complex disassembly (GO:0032984)2.63455468
130mitotic G1 DNA damage checkpoint (GO:0031571)2.59554082
131establishment of integrated proviral latency (GO:0075713)2.58239435
132oxygen transport (GO:0015671)2.58023865
133DNA replication-independent nucleosome organization (GO:0034724)2.57595509
134regulation of histone H3-K9 methylation (GO:0051570)2.56333555
135negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55808099
136L-alpha-amino acid transmembrane transport (GO:1902475)2.55317730
137tRNA aminoacylation for protein translation (GO:0006418)2.55214164
138proline metabolic process (GO:0006560)2.53853988
139histone exchange (GO:0043486)2.53155415
140regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.50202775
141anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.49046930
142pigment metabolic process (GO:0042440)2.49013486
143base-excision repair (GO:0006284)2.48356049
144mitotic G2/M transition checkpoint (GO:0044818)2.46206309
145negative regulation of chromosome segregation (GO:0051985)2.46071758
146iron ion import (GO:0097286)2.43861935
147tRNA aminoacylation (GO:0043039)2.43426498
148amino acid activation (GO:0043038)2.43426498
149negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.43076831
150negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.43076831
151negative regulation of mitotic sister chromatid segregation (GO:0033048)2.43076831
152negative regulation of mitotic sister chromatid separation (GO:2000816)2.43076831
153negative regulation of sister chromatid segregation (GO:0033046)2.43076831
154mitotic G2 DNA damage checkpoint (GO:0007095)2.42986198
155kinetochore organization (GO:0051383)2.41478289
156blood coagulation, intrinsic pathway (GO:0007597)2.38892493
157regulation of response to osmotic stress (GO:0047484)2.37893565
158positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.37829753
159nuclear envelope reassembly (GO:0031468)2.36864093
160mitotic nuclear envelope reassembly (GO:0007084)2.36864093
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.36683860
162negative regulation of ligase activity (GO:0051352)2.34699017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.39483222
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.98700443
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.06243995
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.10886740
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81681177
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72759395
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69746443
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.65371385
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46590194
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39016408
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.34279670
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33010023
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28223376
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27020449
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.26711263
16AR_21909140_ChIP-Seq_LNCAP_Human2.21839694
17MYC_22102868_ChIP-Seq_BL_Human2.16631766
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16452154
19XRN2_22483619_ChIP-Seq_HELA_Human2.14735255
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.12921075
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05546482
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.02473628
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98128014
24* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97757629
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.97501545
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93969063
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.86432956
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85947919
29VDR_23849224_ChIP-Seq_CD4+_Human1.85218503
30ZFX_18555785_ChIP-Seq_MESCs_Mouse1.84475778
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.83813998
32* DCP1A_22483619_ChIP-Seq_HELA_Human1.80866976
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79054147
34* GABP_19822575_ChIP-Seq_HepG2_Human1.75977110
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72531392
36GATA1_22025678_ChIP-Seq_K562_Human1.72504339
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.69360214
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68356181
39* RXR_22158963_ChIP-Seq_LIVER_Mouse1.67218856
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62924836
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62297915
42FOXP3_21729870_ChIP-Seq_TREG_Human1.59507776
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54621760
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.53815781
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52581010
46VDR_21846776_ChIP-Seq_THP-1_Human1.49985192
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49404363
48GATA1_19941826_ChIP-Seq_K562_Human1.48923053
49TTF2_22483619_ChIP-Seq_HELA_Human1.48263389
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44764445
51* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43456870
52* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40771884
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40658440
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37677025
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35522467
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33957652
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33709502
58CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33072005
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32549613
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32484726
61ZNF263_19887448_ChIP-Seq_K562_Human1.32046984
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32031754
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31297182
64CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.31290527
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.30873825
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30376104
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30183169
68CIITA_25753668_ChIP-Seq_RAJI_Human1.29002805
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27096112
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25762065
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25424152
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25398145
73* KDM5A_27292631_Chip-Seq_BREAST_Human1.23855738
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23681116
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23584664
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22849613
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22039000
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20650769
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19597640
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19341762
81CLOCK_20551151_ChIP-Seq_293T_Human1.18173940
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18156693
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17781412
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17692583
85TFEB_21752829_ChIP-Seq_HELA_Human1.16729904
86TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.15708770
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15025607
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.13455339
89SCL_19346495_ChIP-Seq_HPC-7_Human1.11889310
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10021865
91* SOX17_20123909_ChIP-Seq_XEN_Mouse1.08652451
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07498056
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.07275106
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06522563
95* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05415451
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04291113
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03709577
98ELK1_19687146_ChIP-ChIP_HELA_Human1.02682642
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02464904
100NANOG_16153702_ChIP-ChIP_HESCs_Human1.01633191
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.01198367
102MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01123270
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00627824
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00527186
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00435941
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00047497
107* GATA1_19941827_ChIP-Seq_MEL_Mouse0.98539575
108TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98245696
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98034535
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97253315
111MYC_18940864_ChIP-ChIP_HL60_Human0.96382822
112SOX2_16153702_ChIP-ChIP_HESCs_Human0.94161045
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94160064
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.93719260
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93589597
116RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92916954
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92447502
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91987249
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91384917
120MAF_26560356_Chip-Seq_TH1_Human0.89337515
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89278190
122* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88515345
123ATF3_27146783_Chip-Seq_COLON_Human0.88447139
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87837860
125RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87310193
126SPI1_23547873_ChIP-Seq_NB4_Human0.87224008
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86290334
128GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85527573
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85121782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo5.00112638
2MP0002139_abnormal_hepatobiliary_system4.22157946
3MP0003806_abnormal_nucleotide_metabolis4.18966192
4MP0006054_spinal_hemorrhage4.17002178
5MP0004147_increased_porphyrin_level3.94533118
6MP0005360_urolithiasis3.72781401
7MP0003693_abnormal_embryo_hatching3.16622653
8MP0004957_abnormal_blastocyst_morpholog3.00986996
9MP0009697_abnormal_copulation2.98505838
10MP0003111_abnormal_nucleus_morphology2.74011883
11MP0005397_hematopoietic_system_phenotyp2.58875967
12MP0001545_abnormal_hematopoietic_system2.58875967
13MP0010094_abnormal_chromosome_stability2.58466721
14MP0005085_abnormal_gallbladder_physiolo2.54461620
15MP0002396_abnormal_hematopoietic_system2.38531124
16MP0009840_abnormal_foam_cell2.34443102
17MP0003077_abnormal_cell_cycle2.30941853
18MP0005365_abnormal_bile_salt2.10619219
19MP0003186_abnormal_redox_activity2.05727213
20MP0001529_abnormal_vocalization1.96397116
21MP0000490_abnormal_crypts_of1.88542755
22MP0003315_abnormal_perineum_morphology1.84722655
23MP0008875_abnormal_xenobiotic_pharmacok1.83699359
24MP0010352_gastrointestinal_tract_polyps1.80472688
25MP0003705_abnormal_hypodermis_morpholog1.76369038
26MP0008057_abnormal_DNA_replication1.73589221
27MP0004272_abnormal_basement_membrane1.73318312
28MP0008789_abnormal_olfactory_epithelium1.71402767
29MP0003941_abnormal_skin_development1.64253148
30MP0003191_abnormal_cellular_cholesterol1.61174745
31MP0010329_abnormal_lipoprotein_level1.60557883
32MP0008007_abnormal_cellular_replicative1.60318420
33MP0008995_early_reproductive_senescence1.58651696
34MP0010307_abnormal_tumor_latency1.55577200
35MP0003890_abnormal_embryonic-extraembry1.55191222
36MP0003566_abnormal_cell_adhesion1.54899825
37MP0006036_abnormal_mitochondrial_physio1.53834853
38MP0001730_embryonic_growth_arrest1.51344518
39MP0005499_abnormal_olfactory_system1.48952916
40MP0005394_taste/olfaction_phenotype1.48952916
41MP0009333_abnormal_splenocyte_physiolog1.47379002
42MP0008058_abnormal_DNA_repair1.46281823
43MP0003252_abnormal_bile_duct1.45612272
44MP0005083_abnormal_biliary_tract1.43290178
45MP0005451_abnormal_body_composition1.42805094
46MP0005636_abnormal_mineral_homeostasis1.42078202
47MP0000609_abnormal_liver_physiology1.39120004
48MP0004808_abnormal_hematopoietic_stem1.37554385
49MP0001666_abnormal_nutrient_absorption1.35433140
50MP0000350_abnormal_cell_proliferation1.34963108
51MP0005319_abnormal_enzyme/_coenzyme1.31308976
52MP0008438_abnormal_cutaneous_collagen1.26899824
53MP0000598_abnormal_liver_morphology1.26427501
54MP0005332_abnormal_amino_acid1.25251486
55MP0001293_anophthalmia1.24978453
56MP0002084_abnormal_developmental_patter1.24550335
57MP0002398_abnormal_bone_marrow1.24086186
58MP0009384_cardiac_valve_regurgitation1.21868939
59MP0002085_abnormal_embryonic_tissue1.19354452
60MP0002019_abnormal_tumor_incidence1.16359638
61MP0002080_prenatal_lethality1.15371234
62MP0006035_abnormal_mitochondrial_morpho1.15370593
63MP0002722_abnormal_immune_system1.13568158
64MP0001915_intracranial_hemorrhage1.12607014
65MP0000689_abnormal_spleen_morphology1.12240899
66MP0003123_paternal_imprinting1.11853008
67MP0000313_abnormal_cell_death1.11840902
68MP0005584_abnormal_enzyme/coenzyme_acti1.11527481
69MP0010234_abnormal_vibrissa_follicle1.10803998
70MP0001853_heart_inflammation1.08182088
71MP0000358_abnormal_cell_content/1.07271578
72MP0001661_extended_life_span1.07172200
73MP0008932_abnormal_embryonic_tissue1.06989775
74MP0000685_abnormal_immune_system1.06762951
75MP0005464_abnormal_platelet_physiology1.06036625
76MP0001727_abnormal_embryo_implantation1.04706352
77MP0003221_abnormal_cardiomyocyte_apopto1.04466813
78MP0000516_abnormal_urinary_system1.03988574
79MP0005367_renal/urinary_system_phenotyp1.03988574
80MP0001764_abnormal_homeostasis1.03407362
81MP0002877_abnormal_melanocyte_morpholog1.03183052
82MP0005623_abnormal_meninges_morphology1.02340086
83MP0002429_abnormal_blood_cell1.01187591
84MP0001697_abnormal_embryo_size1.00047875
85MP0000465_gastrointestinal_hemorrhage0.99645762
86MP0008469_abnormal_protein_level0.99517967
87MP0002086_abnormal_extraembryonic_tissu0.97547566
88MP0002697_abnormal_eye_size0.94284001
89MP0002132_abnormal_respiratory_system0.92754993
90MP0005384_cellular_phenotype0.91350314
91MP0003436_decreased_susceptibility_to0.91253938
92MP0000537_abnormal_urethra_morphology0.90898518
93MP0009643_abnormal_urine_homeostasis0.88209677
94MP0002234_abnormal_pharynx_morphology0.87191510
95MP0009764_decreased_sensitivity_to0.87026079
96MP0000703_abnormal_thymus_morphology0.86483113
97MP0002938_white_spotting0.86215202
98MP0003763_abnormal_thymus_physiology0.85922809
99MP0010030_abnormal_orbit_morphology0.85049097
100MP0000428_abnormal_craniofacial_morphol0.84847424
101MP0008260_abnormal_autophagy0.82810191
102MP0004947_skin_inflammation0.81141623
103MP0003567_abnormal_fetal_cardiomyocyte0.80891278
104MP0005075_abnormal_melanosome_morpholog0.80160209
105MP0005023_abnormal_wound_healing0.79985298
106MP0003121_genomic_imprinting0.79107610
107MP0010368_abnormal_lymphatic_system0.78519777
108MP0001243_abnormal_dermal_layer0.78418434
109MP0000604_amyloidosis0.78140978
110MP0005266_abnormal_metabolism0.77959880
111MP0005621_abnormal_cell_physiology0.77754103
112MP0005380_embryogenesis_phenotype0.76377634
113MP0001672_abnormal_embryogenesis/_devel0.76377634
114MP0003172_abnormal_lysosome_physiology0.76276916
115MP0009763_increased_sensitivity_to0.76186803
116MP0003385_abnormal_body_wall0.75626267
117MP0009703_decreased_birth_body0.75323021
118MP0008004_abnormal_stomach_pH0.74925635
119MP0003984_embryonic_growth_retardation0.74561414
120MP0009672_abnormal_birth_weight0.74235272
121MP0002092_abnormal_eye_morphology0.73695990
122MP0003942_abnormal_urinary_system0.72617649
123MP0002088_abnormal_embryonic_growth/wei0.72605268
124MP0000716_abnormal_immune_system0.72253890
125MP0000477_abnormal_intestine_morphology0.71937471
126MP0003786_premature_aging0.71802030
127MP0003943_abnormal_hepatobiliary_system0.71753949
128MP0009931_abnormal_skin_appearance0.71186929
129MP0009379_abnormal_foot_pigmentation0.70973151
130MP0000858_altered_metastatic_potential0.70949479
131MP0004197_abnormal_fetal_growth/weight/0.70840190
132MP0002233_abnormal_nose_morphology0.69523584
133MP0003718_maternal_effect0.68393747
134MP0003195_calcinosis0.68085975
135MP0003011_delayed_dark_adaptation0.67987060
136MP0000467_abnormal_esophagus_morphology0.67174723
137MP0003868_abnormal_feces_composition0.66986126
138MP0000566_synostosis0.66810399
139MP0004019_abnormal_vitamin_homeostasis0.66425072
140MP0008873_increased_physiological_sensi0.66407265
141MP0005501_abnormal_skin_physiology0.66186733
142MP0008770_decreased_survivor_rate0.66181891
143MP0003300_gastrointestinal_ulcer0.66120597
144MP0009785_altered_susceptibility_to0.65072938
145MP0005084_abnormal_gallbladder_morpholo0.64616664
146MP0001286_abnormal_eye_development0.64123674
147MP0005376_homeostasis/metabolism_phenot0.63639744
148MP0005025_abnormal_response_to0.63382739
149MP0008775_abnormal_heart_ventricle0.62446739
150MP0005220_abnormal_exocrine_pancreas0.61388028

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)8.53794598
2Abnormal number of erythroid precursors (HP:0012131)6.44981217
3Abnormality of cells of the erythroid lineage (HP:0012130)6.19707935
4Poikilocytosis (HP:0004447)4.46336403
5Reticulocytosis (HP:0001923)4.46314291
6Acanthocytosis (HP:0001927)4.37382964
7Increased mean platelet volume (HP:0011877)4.04903183
8Abnormality of reticulocytes (HP:0004312)3.92066705
9Increased serum ferritin (HP:0003281)3.62162251
10Hyperbilirubinemia (HP:0002904)3.53564423
11Abnormal platelet volume (HP:0011876)3.45381155
12Hypobetalipoproteinemia (HP:0003563)3.33537108
13Pallor (HP:0000980)3.31203000
14Abnormality of iron homeostasis (HP:0011031)3.27603790
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.23483289
16Spastic diplegia (HP:0001264)3.16318231
17Abnormality of transition element cation homeostasis (HP:0011030)3.13935303
18Oral leukoplakia (HP:0002745)3.13862295
19Birth length less than 3rd percentile (HP:0003561)3.10329118
20Microretrognathia (HP:0000308)2.99196317
21Reticulocytopenia (HP:0001896)2.95626552
22Abnormality of pyrimidine metabolism (HP:0004353)2.90820457
23Macrocytic anemia (HP:0001972)2.86618211
24Abnormality of aromatic amino acid family metabolism (HP:0004338)2.81647383
25Microvesicular hepatic steatosis (HP:0001414)2.79937402
26Petechiae (HP:0000967)2.78123888
27Aplastic anemia (HP:0001915)2.74115723
28Deep venous thrombosis (HP:0002625)2.73443711
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66719771
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66719771
31Intrahepatic cholestasis (HP:0001406)2.64048465
32Polycythemia (HP:0001901)2.63788818
33Cholecystitis (HP:0001082)2.62792052
34Abnormal gallbladder physiology (HP:0012438)2.62792052
35Vertebral compression fractures (HP:0002953)2.62565380
36Hyperammonemia (HP:0001987)2.62235320
37Increased hepatocellular lipid droplets (HP:0006565)2.60383428
38Menorrhagia (HP:0000132)2.59346470
39Hepatocellular carcinoma (HP:0001402)2.57738025
40Degeneration of anterior horn cells (HP:0002398)2.57416840
41Abnormality of the anterior horn cell (HP:0006802)2.57416840
42Abnormal hemoglobin (HP:0011902)2.51168019
43Xanthomatosis (HP:0000991)2.45270388
44Ragged-red muscle fibers (HP:0003200)2.44100035
45Cholelithiasis (HP:0001081)2.42304809
46Cortical dysplasia (HP:0002539)2.33796271
47Prolonged bleeding time (HP:0003010)2.31372306
48Nausea (HP:0002018)2.31109510
49Secondary amenorrhea (HP:0000869)2.23518408
50Diaphragmatic weakness (HP:0009113)2.22980838
51Megaloblastic anemia (HP:0001889)2.22948944
52Abnormal platelet function (HP:0011869)2.21213523
53Impaired platelet aggregation (HP:0003540)2.21213523
54Hypolipoproteinemia (HP:0010981)2.21196054
55Hyperglycinemia (HP:0002154)2.19284289
56Onycholysis (HP:0001806)2.19059490
57Paralysis (HP:0003470)2.18906109
58Shoulder girdle muscle weakness (HP:0003547)2.17991191
59Abnormal umbilical cord blood vessels (HP:0011403)2.17928864
60Single umbilical artery (HP:0001195)2.17928864
61Abnormality of the fetal cardiovascular system (HP:0010948)2.17928864
62Epistaxis (HP:0000421)2.14273115
63Abnormality of sulfur amino acid metabolism (HP:0004339)2.12412190
64Hypoplasia of the pons (HP:0012110)2.12402030
65Chromsome breakage (HP:0040012)2.12242224
66Brushfield spots (HP:0001088)2.11556614
67Pancreatic islet-cell hyperplasia (HP:0004510)2.10715238
68Hypoglycemic coma (HP:0001325)2.10450842
69Abnormality of alanine metabolism (HP:0010916)2.10131314
70Hyperalaninemia (HP:0003348)2.10131314
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10131314
72Abnormality of nucleobase metabolism (HP:0010932)2.09094569
73Abnormal gallbladder morphology (HP:0012437)2.08562681
74Multiple enchondromatosis (HP:0005701)2.08126431
75Reduced antithrombin III activity (HP:0001976)2.07197182
76Medulloblastoma (HP:0002885)2.05046883
77Cerebral palsy (HP:0100021)2.04169921
78Abnormal protein glycosylation (HP:0012346)2.02423501
79Abnormal glycosylation (HP:0012345)2.02423501
80Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02423501
81Abnormal protein N-linked glycosylation (HP:0012347)2.02423501
82Gonadal dysgenesis (HP:0000133)2.02219900
83Global brain atrophy (HP:0002283)2.01837925
84Thrombocytosis (HP:0001894)2.00555498
85Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99727818
86Increased serum lactate (HP:0002151)1.98329824
87Orthostatic hypotension (HP:0001278)1.97965180
88Type I transferrin isoform profile (HP:0003642)1.97833685
89Premature rupture of membranes (HP:0001788)1.97457996
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.97308676
91Abnormality of chromosome stability (HP:0003220)1.95387675
92Short middle phalanx of the 5th finger (HP:0004220)1.95353418
93Hypochromic microcytic anemia (HP:0004840)1.94179138
94Abnormality of the Achilles tendon (HP:0005109)1.91746563
95Delayed CNS myelination (HP:0002188)1.91039631
96Increased serum pyruvate (HP:0003542)1.90945340
97Ileus (HP:0002595)1.89801629
98Poor head control (HP:0002421)1.88041658
99Hypoglycemic seizures (HP:0002173)1.87864524
100Atrophy/Degeneration involving motor neurons (HP:0007373)1.87007932
101Renal Fanconi syndrome (HP:0001994)1.85968972
102Microcytic anemia (HP:0001935)1.85785250
103Autoimmune thrombocytopenia (HP:0001973)1.84826309
104Gout (HP:0001997)1.84413186
105Increased muscle lipid content (HP:0009058)1.81844414
106Postnatal microcephaly (HP:0005484)1.80931370
107Cutaneous photosensitivity (HP:0000992)1.80853794
108Myelodysplasia (HP:0002863)1.80660700
109Ketosis (HP:0001946)1.80249504
110Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80024338
111Abnormality of endocrine pancreas physiology (HP:0012093)1.76451770
112Abnormality of the pancreatic islet cells (HP:0006476)1.76451770
113Basal cell carcinoma (HP:0002671)1.75676440
114Insomnia (HP:0100785)1.75580744
115Overlapping toe (HP:0001845)1.73851960
116Selective tooth agenesis (HP:0001592)1.72824176
117Abnormality of the pons (HP:0007361)1.72690780
118Increased intramyocellular lipid droplets (HP:0012240)1.72261632
119Abnormal hair whorl (HP:0010721)1.72191324
120Achilles tendon contracture (HP:0001771)1.71884941
121Pancytopenia (HP:0001876)1.71855974
122Abnormality of the gallbladder (HP:0005264)1.71821419
123Abnormality of the umbilical cord (HP:0010881)1.71747784
124Protrusio acetabuli (HP:0003179)1.71449891
125Nephroblastoma (Wilms tumor) (HP:0002667)1.69092306
126Meckel diverticulum (HP:0002245)1.68711990
127Abnormality of purine metabolism (HP:0004352)1.68231626
128Hepatocellular necrosis (HP:0001404)1.66546567
129Hypoparathyroidism (HP:0000829)1.65944935
130Symptomatic seizures (HP:0011145)1.65591595
131Abnormality of glutamine family amino acid metabolism (HP:0010902)1.65584854
132Abnormality of methionine metabolism (HP:0010901)1.64955828
133Cerebellar dysplasia (HP:0007033)1.64513630
134Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64137317
135Abnormality of fatty-acid metabolism (HP:0004359)1.64078787
136Abnormality of the thoracic spine (HP:0100711)1.63589244
137Nonimmune hydrops fetalis (HP:0001790)1.63533355
138Progressive muscle weakness (HP:0003323)1.63371485
139Duodenal stenosis (HP:0100867)1.63112356
140Small intestinal stenosis (HP:0012848)1.63112356
141Thrombophlebitis (HP:0004418)1.62799287
142Lipid accumulation in hepatocytes (HP:0006561)1.61815109
143Prolonged partial thromboplastin time (HP:0003645)1.61787148
144Ankle contracture (HP:0006466)1.61746949
145Abnormality of the common coagulation pathway (HP:0010990)1.61436362
146Delusions (HP:0000746)1.61374180
147Hyperlipoproteinemia (HP:0010980)1.61111966
148CNS demyelination (HP:0007305)1.60921834
149Abnormality of the tricuspid valve (HP:0001702)1.60881759
150Abnormality of serum amino acid levels (HP:0003112)1.60871693
151Hepatic necrosis (HP:0002605)1.60746462
152Pelvic girdle muscle weakness (HP:0003749)1.60175654
153Abnormalities of placenta or umbilical cord (HP:0001194)1.58143702
154Abnormality of glycolysis (HP:0004366)1.58024130
155Neoplasm of the liver (HP:0002896)1.57689797
156Tetraparesis (HP:0002273)1.56766590
157Hypertensive crisis (HP:0100735)1.56109711
158Missing ribs (HP:0000921)1.54096146
159Termporal pattern (HP:0011008)1.53648439

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.15093329
2CDC73.63167246
3SCYL23.49364963
4WEE13.40785016
5BUB13.28879622
6EIF2AK13.18876926
7PKN22.80387529
8MAP3K102.59649877
9VRK22.53742699
10EEF2K2.23901681
11NEK22.18009660
12NEK12.07413862
13BCKDK2.00332736
14TRIB31.92735152
15FLT31.88756031
16EIF2AK31.87021964
17ERN11.81591889
18ACVR1B1.81045000
19MAP3K111.79807260
20TAF11.78551065
21KDR1.70868246
22PLK41.70620417
23RPS6KA41.69059735
24PIM21.67543858
25BCR1.66599494
26DYRK31.66587843
27BRSK21.61383572
28VRK11.59200609
29TESK21.58103087
30ZAK1.52608816
31CCNB11.47942051
32MAP2K71.46482935
33MAP3K81.43875795
34TRIM281.40661680
35CDK41.39881491
36LRRK21.39485918
37BRSK11.36984217
38STK101.33685823
39TIE11.31845247
40MAP4K21.30980423
41MST41.26285145
42MAP4K11.24492929
43TYK21.23238020
44CDK191.21138511
45TGFBR11.21040804
46PAK41.18332102
47MKNK11.17768464
48PLK11.12450252
49CSNK1G31.11344169
50ATR1.09355741
51TLK11.04573259
52AURKB1.04459397
53ZAP701.04354734
54RPS6KB21.04244689
55TTK1.02830444
56CLK11.02253215
57RAF10.98841092
58GRK60.96542771
59MAP3K50.95749346
60PASK0.95239341
61CSNK1G10.94815593
62TBK10.92753803
63CDK70.92606324
64AURKA0.92426764
65ABL20.92178286
66MAP2K30.90253299
67JAK30.85531326
68DAPK10.85352906
69ERBB40.84430835
70CSNK1A1L0.84409906
71TAOK20.83388357
72TESK10.82545887
73PRPF4B0.79650274
74JAK20.78809688
75CSNK1G20.78312969
76MAPK110.76641894
77MAP3K120.74961287
78CDK80.73644271
79IRAK30.72956735
80PIM10.70302890
81KSR20.70057184
82DYRK20.69399899
83STK30.69210577
84CDK60.67045215
85SIK10.65496612
86EIF2AK20.65354340
87ERBB30.65288894
88TSSK60.63905266
89STK40.63390727
90NUAK10.62186540
91LATS10.61674754
92CHEK20.61644590
93MAP3K40.59593055
94MAP3K60.57402744
95CHEK10.56294062
96KSR10.56281379
97DYRK1B0.56251655
98SRPK10.55278644
99MAPKAPK30.54222093
100PTK60.53568897
101STK160.53496045
102RPS6KA50.52453666
103PBK0.51788487
104TGFBR20.51240718
105BMX0.49942339
106CSNK2A20.49468295
107MET0.48701732
108CSNK2A10.46627289
109BRD40.46511594
110KIT0.46328162
111CDK10.45997045
112PRKDC0.45831026
113FGFR40.45812143
114CDK140.44832597
115TAOK10.42842678
116MATK0.42757535
117CDK20.41743415
118RET0.41647987
119CDK180.41596005
120PLK20.41586185
121NEK90.40285580
122ATM0.39246081
123CDK90.39170271
124CDK150.38144515
125EPHA20.37908751
126AKT20.36650170
127CDK11A0.36164060
128PAK10.35860130
129CDK120.35426520
130LIMK10.35202139
131PAK20.34737746
132MAP3K130.34364561
133BRAF0.31861483
134CAMKK10.30452935
135BTK0.30339044
136MINK10.30275533
137PLK30.28682082
138LYN0.27543796
139DAPK20.27442868
140CSF1R0.27132710
141SYK0.26965405
142ARAF0.25260579
143ALK0.24423747
144ERBB20.23919233

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79934244
2Ribosome_Homo sapiens_hsa030103.23283591
3One carbon pool by folate_Homo sapiens_hsa006703.03124117
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.02435359
5Mismatch repair_Homo sapiens_hsa034302.81085122
6Proteasome_Homo sapiens_hsa030502.29948196
7Pyrimidine metabolism_Homo sapiens_hsa002402.26219129
8Base excision repair_Homo sapiens_hsa034102.23623472
9Fatty acid elongation_Homo sapiens_hsa000622.20682072
10Sulfur relay system_Homo sapiens_hsa041222.16512234
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14599003
12Folate biosynthesis_Homo sapiens_hsa007902.14116523
13Spliceosome_Homo sapiens_hsa030402.08752790
14Cysteine and methionine metabolism_Homo sapiens_hsa002702.02599036
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02210582
16Selenocompound metabolism_Homo sapiens_hsa004501.98514044
17Protein export_Homo sapiens_hsa030601.94040609
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.92495491
19RNA transport_Homo sapiens_hsa030131.88215372
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.86890597
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84139819
22Nucleotide excision repair_Homo sapiens_hsa034201.80896076
23Biosynthesis of amino acids_Homo sapiens_hsa012301.78993554
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.75745242
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75119949
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72558563
27Cell cycle_Homo sapiens_hsa041101.72506305
28Caffeine metabolism_Homo sapiens_hsa002321.66343042
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65868903
30Steroid biosynthesis_Homo sapiens_hsa001001.63692216
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.57714421
32Pentose phosphate pathway_Homo sapiens_hsa000301.46754125
33Homologous recombination_Homo sapiens_hsa034401.43340578
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42824392
35Arginine biosynthesis_Homo sapiens_hsa002201.42380752
36RNA polymerase_Homo sapiens_hsa030201.40600870
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37977219
38Carbon metabolism_Homo sapiens_hsa012001.37292758
39Systemic lupus erythematosus_Homo sapiens_hsa053221.33840773
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.29495981
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29238956
42Nitrogen metabolism_Homo sapiens_hsa009101.26252275
43Fatty acid degradation_Homo sapiens_hsa000711.21999306
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21858291
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20569006
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18827017
47p53 signaling pathway_Homo sapiens_hsa041151.17986273
48Basal transcription factors_Homo sapiens_hsa030221.10478967
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99619953
50Peroxisome_Homo sapiens_hsa041460.99292012
51Sulfur metabolism_Homo sapiens_hsa009200.95638349
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94482266
53N-Glycan biosynthesis_Homo sapiens_hsa005100.94442481
54Glutathione metabolism_Homo sapiens_hsa004800.92647892
55Pyruvate metabolism_Homo sapiens_hsa006200.90888567
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89456762
57Fat digestion and absorption_Homo sapiens_hsa049750.87504859
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.85422166
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84926571
60RNA degradation_Homo sapiens_hsa030180.84539236
61Complement and coagulation cascades_Homo sapiens_hsa046100.84200207
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84042243
63* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81776563
64Purine metabolism_Homo sapiens_hsa002300.79069003
65Non-homologous end-joining_Homo sapiens_hsa034500.77926847
66Tryptophan metabolism_Homo sapiens_hsa003800.77416649
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75339841
68Oxidative phosphorylation_Homo sapiens_hsa001900.74144344
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68212245
70Herpes simplex infection_Homo sapiens_hsa051680.67857263
71Bile secretion_Homo sapiens_hsa049760.66563346
72Viral carcinogenesis_Homo sapiens_hsa052030.66560496
73Huntingtons disease_Homo sapiens_hsa050160.65439508
74Thyroid cancer_Homo sapiens_hsa052160.64779935
75Propanoate metabolism_Homo sapiens_hsa006400.63841229
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63773845
77ECM-receptor interaction_Homo sapiens_hsa045120.63397869
78Vitamin B6 metabolism_Homo sapiens_hsa007500.63146374
79beta-Alanine metabolism_Homo sapiens_hsa004100.61918029
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60773521
81TGF-beta signaling pathway_Homo sapiens_hsa043500.57141354
82Legionellosis_Homo sapiens_hsa051340.57058173
83Arginine and proline metabolism_Homo sapiens_hsa003300.56523674
84Fructose and mannose metabolism_Homo sapiens_hsa000510.56333140
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56269633
86PPAR signaling pathway_Homo sapiens_hsa033200.55148135
87Antigen processing and presentation_Homo sapiens_hsa046120.54129177
88Bladder cancer_Homo sapiens_hsa052190.53924525
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52984401
90Vitamin digestion and absorption_Homo sapiens_hsa049770.52968569
91Fatty acid metabolism_Homo sapiens_hsa012120.51683364
92Chemical carcinogenesis_Homo sapiens_hsa052040.50625356
93Starch and sucrose metabolism_Homo sapiens_hsa005000.50195474
94Fanconi anemia pathway_Homo sapiens_hsa034600.49108816
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48366407
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.47163267
97* Metabolic pathways_Homo sapiens_hsa011000.45233944
98Epstein-Barr virus infection_Homo sapiens_hsa051690.44160006
99Galactose metabolism_Homo sapiens_hsa000520.44158923
100Sphingolipid metabolism_Homo sapiens_hsa006000.43739746
101Vibrio cholerae infection_Homo sapiens_hsa051100.42691030
102ABC transporters_Homo sapiens_hsa020100.41668795
103mRNA surveillance pathway_Homo sapiens_hsa030150.41415939
104Regulation of autophagy_Homo sapiens_hsa041400.41238417
105Tyrosine metabolism_Homo sapiens_hsa003500.40766518
106Apoptosis_Homo sapiens_hsa042100.39608032
107Oocyte meiosis_Homo sapiens_hsa041140.38707543
108Retinol metabolism_Homo sapiens_hsa008300.38326949
109Parkinsons disease_Homo sapiens_hsa050120.36506705
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.35266587
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34261432
112Small cell lung cancer_Homo sapiens_hsa052220.34239358
113Phenylalanine metabolism_Homo sapiens_hsa003600.33800863
114Hepatitis B_Homo sapiens_hsa051610.32774990
115Shigellosis_Homo sapiens_hsa051310.32122186
116Staphylococcus aureus infection_Homo sapiens_hsa051500.29872823
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28625078
118Renin-angiotensin system_Homo sapiens_hsa046140.28054342
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27075416
120Alzheimers disease_Homo sapiens_hsa050100.26832440
121HTLV-I infection_Homo sapiens_hsa051660.25703761
122Chronic myeloid leukemia_Homo sapiens_hsa052200.25681203
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.25236835
124Alcoholism_Homo sapiens_hsa050340.24083551
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23451485
126Lysine degradation_Homo sapiens_hsa003100.22459978
127Butanoate metabolism_Homo sapiens_hsa006500.21964233
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20749012

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