MIPOL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a coiled-coil domain-containing protein. The encoded protein may function as a tumor suppressor. A translocation that results in truncation of the protein encoded by this locus has been associated with mirror-image polydactyly, also known as Laurin-Sandrow Syndrome. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)6.40025689
2doxorubicin metabolic process (GO:0044598)6.40025689
3daunorubicin metabolic process (GO:0044597)6.40025689
4regulation of pigment cell differentiation (GO:0050932)5.09713862
5positive regulation of developmental pigmentation (GO:0048087)5.07741436
6kinetochore organization (GO:0051383)4.68832006
7snRNA transcription (GO:0009301)4.39336210
8indole-containing compound catabolic process (GO:0042436)4.31349837
9indolalkylamine catabolic process (GO:0046218)4.31349837
10tryptophan catabolic process (GO:0006569)4.31349837
11monoubiquitinated protein deubiquitination (GO:0035520)4.30908383
12establishment of protein localization to Golgi (GO:0072600)4.28746479
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.15819639
14negative regulation of translation, ncRNA-mediated (GO:0040033)4.15819639
15regulation of translation, ncRNA-mediated (GO:0045974)4.15819639
16kynurenine metabolic process (GO:0070189)4.13645421
17interkinetic nuclear migration (GO:0022027)4.12609683
18CENP-A containing nucleosome assembly (GO:0034080)4.10600082
19negative regulation of sodium ion transport (GO:0010766)4.09861563
20kinetochore assembly (GO:0051382)4.08032505
21regulation of establishment of cell polarity (GO:2000114)4.04348476
22protein K48-linked deubiquitination (GO:0071108)3.96618275
23signal peptide processing (GO:0006465)3.96345714
24negative regulation of protein localization to cell surface (GO:2000009)3.94642971
25chromatin remodeling at centromere (GO:0031055)3.91441729
26indolalkylamine metabolic process (GO:0006586)3.90708625
27aminoglycoside antibiotic metabolic process (GO:0030647)3.89763961
28cell wall macromolecule metabolic process (GO:0044036)3.87425549
29cell wall macromolecule catabolic process (GO:0016998)3.87425549
30regulation of hippo signaling (GO:0035330)3.81463508
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.75226691
32DNA strand renaturation (GO:0000733)3.74383600
33neural tube formation (GO:0001841)3.69873871
34tryptophan metabolic process (GO:0006568)3.63615834
35regulation of establishment or maintenance of cell polarity (GO:0032878)3.59044664
36negative regulation of systemic arterial blood pressure (GO:0003085)3.58749265
37lipid translocation (GO:0034204)3.57675971
38phospholipid translocation (GO:0045332)3.57675971
39regulation of DNA endoreduplication (GO:0032875)3.55396378
40regulation of posttranscriptional gene silencing (GO:0060147)3.53847457
41regulation of gene silencing by miRNA (GO:0060964)3.53847457
42regulation of gene silencing by RNA (GO:0060966)3.53847457
43motile cilium assembly (GO:0044458)3.52510005
44endosome to pigment granule transport (GO:0043485)3.47575298
45endosome to melanosome transport (GO:0035646)3.47575298
46negative regulation of DNA-dependent DNA replication (GO:2000104)3.45506803
47behavioral response to nicotine (GO:0035095)3.44092953
48intraciliary transport (GO:0042073)3.42393799
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.41450060
50oxidative demethylation (GO:0070989)3.40650716
51protein K11-linked deubiquitination (GO:0035871)3.31029514
52protein targeting to lysosome (GO:0006622)3.29625506
53establishment of protein localization to vacuole (GO:0072666)3.29625506
54protein targeting to vacuole (GO:0006623)3.29625506
55cilium or flagellum-dependent cell motility (GO:0001539)3.29540499
56synaptic vesicle docking involved in exocytosis (GO:0016081)3.28460667
57cullin deneddylation (GO:0010388)3.27705184
58meiotic chromosome segregation (GO:0045132)3.27660191
59microtubule depolymerization (GO:0007019)3.27556056
60nuclear pore complex assembly (GO:0051292)3.26399699
61cellular response to ethanol (GO:0071361)3.24722761
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23824924
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23824924
64detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.20785336
65flavonoid metabolic process (GO:0009812)3.19355731
66regulation of nuclear cell cycle DNA replication (GO:0033262)3.17060405
67histone exchange (GO:0043486)3.15696858
68detection of light stimulus involved in visual perception (GO:0050908)3.14491653
69detection of light stimulus involved in sensory perception (GO:0050962)3.14491653
70protein neddylation (GO:0045116)3.13673764
71centriole assembly (GO:0098534)3.12743321
72reflex (GO:0060004)3.10769736
73regulation of sarcomere organization (GO:0060297)3.10437885
74indole-containing compound metabolic process (GO:0042430)3.09970621
75serotonin metabolic process (GO:0042428)3.07740565
76gamma-aminobutyric acid transport (GO:0015812)3.07010577
77deoxyribonucleotide biosynthetic process (GO:0009263)3.06799185
78DNA replication-independent nucleosome organization (GO:0034724)3.03172823
79DNA replication-independent nucleosome assembly (GO:0006336)3.03172823
80mesenchymal cell differentiation involved in kidney development (GO:0072161)3.02937808
81mesenchymal cell differentiation involved in renal system development (GO:2001012)3.02937808
82preassembly of GPI anchor in ER membrane (GO:0016254)3.02426190
83negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01055304
84protein K63-linked deubiquitination (GO:0070536)3.00585186
85sulfation (GO:0051923)2.99724317
86fucose catabolic process (GO:0019317)2.97790087
87L-fucose metabolic process (GO:0042354)2.97790087
88L-fucose catabolic process (GO:0042355)2.97790087
89glomerulus development (GO:0032835)2.97716092
90nuclear pore organization (GO:0006999)2.97499092
91fusion of sperm to egg plasma membrane (GO:0007342)2.97405184
92protein deneddylation (GO:0000338)2.95311810
93cellular response to sterol (GO:0036315)2.94418143
94cardiovascular system development (GO:0072358)2.92872467
95thyroid hormone metabolic process (GO:0042403)2.91699252
96pericardium development (GO:0060039)2.90625781
97DNA integration (GO:0015074)2.86772830
98primary amino compound metabolic process (GO:1901160)2.86714601
99DNA replication initiation (GO:0006270)2.86434556
100metanephric mesenchyme development (GO:0072075)2.84958781
101photoreceptor cell maintenance (GO:0045494)2.84410948
102glucocorticoid receptor signaling pathway (GO:0042921)2.83967588
103cytoplasmic mRNA processing body assembly (GO:0033962)2.82565796
104mismatch repair (GO:0006298)2.79729423
105limb development (GO:0060173)2.77917273
106appendage development (GO:0048736)2.77917273
107negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.77575716
108multicellular organism reproduction (GO:0032504)2.77001994
109neuronal action potential (GO:0019228)2.76879778
110deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.76834349
111cilium movement (GO:0003341)2.76264458
112deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76095257
113mitotic sister chromatid cohesion (GO:0007064)2.76000758
114cellular ketone body metabolic process (GO:0046950)2.75753195
115pore complex assembly (GO:0046931)2.74012744
116regulation of short-term neuronal synaptic plasticity (GO:0048172)2.73396760
117telomere maintenance via recombination (GO:0000722)2.70598390
118membrane depolarization during action potential (GO:0086010)2.69784819
119pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.69730240
120DNA ligation (GO:0006266)2.69212470
121cilium organization (GO:0044782)2.68377569
122telomere maintenance via semi-conservative replication (GO:0032201)2.68292308
123protein targeting to Golgi (GO:0000042)2.66936367
124endocardial cushion development (GO:0003197)2.66821327
125cilium assembly (GO:0042384)2.65581926
126NAD biosynthetic process (GO:0009435)2.64998334
127microtubule polymerization or depolymerization (GO:0031109)2.64366815
128behavioral response to ethanol (GO:0048149)2.63881500
129negative regulation of mast cell activation (GO:0033004)2.63767339
130nucleus localization (GO:0051647)2.63681378
131microtubule anchoring (GO:0034453)2.63190934
132cell morphogenesis involved in neuron differentiation (GO:0048667)2.62420995
133central nervous system neuron axonogenesis (GO:0021955)2.61257543
134positive regulation of DNA-dependent DNA replication (GO:2000105)2.60629338
135regulation of developmental pigmentation (GO:0048070)2.60153834
136nonmotile primary cilium assembly (GO:0035058)2.58937330
137retrograde transport, vesicle recycling within Golgi (GO:0000301)2.58699379
138histone H3-K4 trimethylation (GO:0080182)2.58497778
139cilium morphogenesis (GO:0060271)2.58104555
140epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.57978684
141regulation of timing of cell differentiation (GO:0048505)2.57800260
142negative regulation of keratinocyte proliferation (GO:0010839)2.57046506
143N-terminal protein amino acid acetylation (GO:0006474)2.56575429
144synapsis (GO:0007129)2.55487460
145replication fork processing (GO:0031297)2.54284885
146mitotic recombination (GO:0006312)2.54282910
147lateral sprouting from an epithelium (GO:0060601)2.54255117
148GPI anchor biosynthetic process (GO:0006506)2.52845300
149histone H3-K9 methylation (GO:0051567)2.52646038
150sperm-egg recognition (GO:0035036)2.51949030
151deoxyribose phosphate biosynthetic process (GO:0046385)2.50743748
1522-deoxyribonucleotide biosynthetic process (GO:0009265)2.50743748
153spermatid nucleus differentiation (GO:0007289)2.50388061
154DNA double-strand break processing (GO:0000729)2.50276418
155epithelial cilium movement (GO:0003351)2.50270960
156kidney mesenchyme development (GO:0072074)2.49688368
157regulation of development, heterochronic (GO:0040034)2.49268192
158tachykinin receptor signaling pathway (GO:0007217)2.48699144
159mesonephros development (GO:0001823)2.48363837
160axoneme assembly (GO:0035082)2.46573206
161regulation of DNA-dependent DNA replication (GO:0090329)2.46502001
162attachment of spindle microtubules to kinetochore (GO:0008608)2.46248951
163transcription elongation from RNA polymerase III promoter (GO:0006385)2.45884873
164termination of RNA polymerase III transcription (GO:0006386)2.45884873
165DNA strand elongation involved in DNA replication (GO:0006271)2.45816120
166UDP-N-acetylglucosamine metabolic process (GO:0006047)2.45577192
167telomere maintenance via telomere lengthening (GO:0010833)2.45326552
168amine catabolic process (GO:0009310)2.44530440
169cellular biogenic amine catabolic process (GO:0042402)2.44530440
170startle response (GO:0001964)2.43527248
171ketone body metabolic process (GO:1902224)2.42616776
172maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.42166749
173DNA strand elongation (GO:0022616)2.41832458
174G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41248690
175inner ear receptor stereocilium organization (GO:0060122)2.40342191
176peptidyl-histidine modification (GO:0018202)2.40332313
177nucleotide-excision repair, DNA gap filling (GO:0006297)2.40161513
178establishment of integrated proviral latency (GO:0075713)2.39561392
179DNA catabolic process, exonucleolytic (GO:0000738)2.39460600
180regulation of mitotic spindle checkpoint (GO:1903504)2.39107811
181regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.39107811
182exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.38683178
183sister chromatid cohesion (GO:0007062)2.38470424
184regulation of centriole replication (GO:0046599)2.38321173
185pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.38203317
186negative regulation of meiosis (GO:0045835)2.37990282
187nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.37875868
188mannosylation (GO:0097502)2.37661653
189energy homeostasis (GO:0097009)2.37316766
190centriole replication (GO:0007099)2.35730073
191metaphase plate congression (GO:0051310)2.35726770
192ribosomal small subunit biogenesis (GO:0042274)2.34718149
193response to X-ray (GO:0010165)2.33195159
194DNA deamination (GO:0045006)2.31715643
195mitotic chromosome condensation (GO:0007076)2.31502292
196GPI anchor metabolic process (GO:0006505)2.31498241
197RNA-dependent DNA replication (GO:0006278)2.29520069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.56668193
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.63465988
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.53955927
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.02377519
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84822934
6EZH2_22144423_ChIP-Seq_EOC_Human2.84819253
7VDR_22108803_ChIP-Seq_LS180_Human2.70034046
8FUS_26573619_Chip-Seq_HEK293_Human2.69764222
9ZNF274_21170338_ChIP-Seq_K562_Hela2.56703673
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49454234
11EWS_26573619_Chip-Seq_HEK293_Human2.37142680
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.35086332
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35077901
14POU5F1_16153702_ChIP-ChIP_HESCs_Human2.28018393
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20426203
16* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19127882
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.16368654
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.14657302
19ELK1_19687146_ChIP-ChIP_HELA_Human2.06857487
20GBX2_23144817_ChIP-Seq_PC3_Human2.03145469
21* STAT3_23295773_ChIP-Seq_U87_Human2.00377956
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92351070
23SMAD4_21799915_ChIP-Seq_A2780_Human1.91772196
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91731359
25AR_21572438_ChIP-Seq_LNCaP_Human1.91040113
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80479594
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78899910
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77323253
29TCF4_23295773_ChIP-Seq_U87_Human1.76561540
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.75277815
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74339743
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74102792
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.72806255
34* TP53_16413492_ChIP-PET_HCT116_Human1.70246077
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.69986908
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69693272
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.68526002
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66523044
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65705590
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65705590
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64750761
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63280108
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61300685
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61261134
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61112650
46TAF15_26573619_Chip-Seq_HEK293_Human1.59598587
47IGF1R_20145208_ChIP-Seq_DFB_Human1.57779325
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.57607735
49BCAT_22108803_ChIP-Seq_LS180_Human1.56134285
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54749196
51DROSHA_22980978_ChIP-Seq_HELA_Human1.53006893
52* AR_25329375_ChIP-Seq_VCAP_Human1.52408154
53* P300_19829295_ChIP-Seq_ESCs_Human1.51217072
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.48753181
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.48723072
56AHR_22903824_ChIP-Seq_MCF-7_Human1.47314523
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46724105
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45416588
59* CBP_20019798_ChIP-Seq_JUKART_Human1.44550889
60* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44550889
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.44494359
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44207194
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.44204586
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43981821
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.43279874
66* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41876083
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41375501
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40733303
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39448727
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.38517538
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37468929
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36166126
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35995240
74P53_22387025_ChIP-Seq_ESCs_Mouse1.35645342
75RUNX2_22187159_ChIP-Seq_PCA_Human1.35387693
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34771612
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.34521401
78* ER_23166858_ChIP-Seq_MCF-7_Human1.33898294
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32543451
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31956428
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.31823027
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.30789235
83* TCF4_22108803_ChIP-Seq_LS180_Human1.30232541
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30111839
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29757057
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29694743
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29369223
88FOXM1_23109430_ChIP-Seq_U2OS_Human1.28378767
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27245597
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.27120605
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26171820
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25542922
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.24484478
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24315381
95* FLI1_21867929_ChIP-Seq_TH2_Mouse1.24250872
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.23214735
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22787343
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.22507229
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.21946807
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21780799
101REST_21632747_ChIP-Seq_MESCs_Mouse1.21755359
102VDR_23849224_ChIP-Seq_CD4+_Human1.21296329
103RNF2_27304074_Chip-Seq_NSC_Mouse1.20896222
104TP53_18474530_ChIP-ChIP_U2OS_Human1.20743848
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.19198721
106MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18820648
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.18810960
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18523844
109IRF1_19129219_ChIP-ChIP_H3396_Human1.18497128
110KDM2B_26808549_Chip-Seq_REH_Human1.17851324
111* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17798836
112P300_18555785_Chip-Seq_ESCs_Mouse1.17720059
113FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17706376
114RXR_22108803_ChIP-Seq_LS180_Human1.17667547
115HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17265047
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16536854
117NMYC_18555785_Chip-Seq_ESCs_Mouse1.16168282
118OCT4_18555785_Chip-Seq_ESCs_Mouse1.15930123
119WT1_19549856_ChIP-ChIP_CCG9911_Human1.15240254
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15212747
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.14757125
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14663419
123KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13529470
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13119109
125SOX9_26525672_Chip-Seq_HEART_Mouse1.12895006
126* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11624443
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11113617
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11019646
129SOX2_16153702_ChIP-ChIP_HESCs_Human1.09290171
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09194784
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08420685
132AR_19668381_ChIP-Seq_PC3_Human1.08006669
133BP1_19119308_ChIP-ChIP_Hs578T_Human1.08002174
134* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07575637
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.07378512
136PIAS1_25552417_ChIP-Seq_VCAP_Human1.07274377
137SMAD3_21741376_ChIP-Seq_HESCs_Human1.07162859
138SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06544274
139SOX2_18555785_Chip-Seq_ESCs_Mouse1.06155302
140RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05668081
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05440744
142* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05154732
143NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04625946
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04625946
145FOXP3_21729870_ChIP-Seq_TREG_Human1.04478193
146DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03952962
147SMAD3_21741376_ChIP-Seq_ESCs_Human1.03144040
148CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03075872
149RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02116833
150NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01601507
151NANOG_19829295_ChIP-Seq_ESCs_Human1.01263537
152SOX2_19829295_ChIP-Seq_ESCs_Human1.01263537
153CDX2_22108803_ChIP-Seq_LS180_Human1.00003103
154* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99938106
155OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99555961
156CJUN_26792858_Chip-Seq_BT549_Human0.98948848
157ZFX_18555785_Chip-Seq_ESCs_Mouse0.98753754
158CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97546726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.12767366
2MP0000566_synostosis5.02718620
3MP0003136_yellow_coat_color3.84683674
4MP0003195_calcinosis3.84023195
5MP0003646_muscle_fatigue3.27267056
6MP0005171_absent_coat_pigmentation2.98025680
7MP0004043_abnormal_pH_regulation2.87445498
8MP0009046_muscle_twitch2.80632435
9MP0001188_hyperpigmentation2.73509459
10MP0002938_white_spotting2.61021862
11MP0009697_abnormal_copulation2.56390513
12MP0006292_abnormal_olfactory_placode2.51570137
13MP0010094_abnormal_chromosome_stability2.44125592
14MP0000678_abnormal_parathyroid_gland2.36685052
15MP0001968_abnormal_touch/_nociception2.34671431
16MP0000427_abnormal_hair_cycle2.23423247
17MP0005551_abnormal_eye_electrophysiolog2.21895859
18MP0003693_abnormal_embryo_hatching2.14678597
19MP0008058_abnormal_DNA_repair2.11436764
20MP0001501_abnormal_sleep_pattern2.05766092
21MP0008057_abnormal_DNA_replication2.02535702
22MP0008007_abnormal_cellular_replicative1.99850258
23MP0000383_abnormal_hair_follicle1.97669731
24MP0003077_abnormal_cell_cycle1.93803905
25MP0008961_abnormal_basal_metabolism1.92839644
26MP0002736_abnormal_nociception_after1.91464652
27MP0009379_abnormal_foot_pigmentation1.86340705
28MP0003941_abnormal_skin_development1.85220444
29MP0002102_abnormal_ear_morphology1.84683456
30MP0002735_abnormal_chemical_nociception1.80897035
31MP0009745_abnormal_behavioral_response1.80731949
32MP0005503_abnormal_tendon_morphology1.73157236
33MP0000372_irregular_coat_pigmentation1.72726462
34MP0001986_abnormal_taste_sensitivity1.71475343
35MP0002249_abnormal_larynx_morphology1.69478908
36MP0001486_abnormal_startle_reflex1.67283230
37MP0003890_abnormal_embryonic-extraembry1.65531566
38MP0008877_abnormal_DNA_methylation1.64730877
39MP0004142_abnormal_muscle_tone1.64633531
40MP0003111_abnormal_nucleus_morphology1.62802860
41MP0002837_dystrophic_cardiac_calcinosis1.57683835
42MP0003121_genomic_imprinting1.57555169
43MP0005174_abnormal_tail_pigmentation1.57055514
44MP0002277_abnormal_respiratory_mucosa1.56921918
45MP0003937_abnormal_limbs/digits/tail_de1.56493238
46MP0000049_abnormal_middle_ear1.56376457
47MP0004130_abnormal_muscle_cell1.55472147
48MP0003045_fibrosis1.54426918
49MP0002132_abnormal_respiratory_system1.49237733
50MP0001346_abnormal_lacrimal_gland1.48786283
51MP0002272_abnormal_nervous_system1.48151089
52MP0010030_abnormal_orbit_morphology1.47493897
53MP0004924_abnormal_behavior1.47108650
54MP0005386_behavior/neurological_phenoty1.47108650
55MP0004145_abnormal_muscle_electrophysio1.47000839
56MP0002064_seizures1.46937917
57MP0002067_abnormal_sensory_capabilities1.43856116
58MP0005409_darkened_coat_color1.43207543
59MP0004133_heterotaxia1.40882835
60MP0001293_anophthalmia1.39106823
61MP0008932_abnormal_embryonic_tissue1.38631254
62MP0002572_abnormal_emotion/affect_behav1.36481931
63MP0003635_abnormal_synaptic_transmissio1.36441312
64MP0000015_abnormal_ear_pigmentation1.36331866
65MP0006276_abnormal_autonomic_nervous1.35830161
66MP0002160_abnormal_reproductive_system1.35332097
67MP0002396_abnormal_hematopoietic_system1.34564971
68MP0005253_abnormal_eye_physiology1.34370983
69MP0002177_abnormal_outer_ear1.33542428
70MP0003880_abnormal_central_pattern1.30073542
71MP0002168_other_aberrant_phenotype1.29099990
72MP0005389_reproductive_system_phenotype1.28773451
73MP0004957_abnormal_blastocyst_morpholog1.27515660
74MP0003385_abnormal_body_wall1.26373191
75MP0005310_abnormal_salivary_gland1.26123421
76MP0009250_abnormal_appendicular_skeleto1.25400374
77MP0003786_premature_aging1.25091768
78MP0002557_abnormal_social/conspecific_i1.22424285
79MP0005410_abnormal_fertilization1.21781456
80MP0005266_abnormal_metabolism1.20983790
81MP0003943_abnormal_hepatobiliary_system1.20857168
82MP0002210_abnormal_sex_determination1.20687790
83MP0008872_abnormal_physiological_respon1.20263208
84MP0000762_abnormal_tongue_morphology1.19960418
85MP0001970_abnormal_pain_threshold1.19348262
86MP0008789_abnormal_olfactory_epithelium1.18401935
87MP0001529_abnormal_vocalization1.18100527
88MP0005379_endocrine/exocrine_gland_phen1.18001735
89MP0002734_abnormal_mechanical_nocicepti1.17999095
90MP0002063_abnormal_learning/memory/cond1.17911115
91MP0005187_abnormal_penis_morphology1.17848269
92MP0000778_abnormal_nervous_system1.17251035
93MP0005645_abnormal_hypothalamus_physiol1.16163436
94MP0001485_abnormal_pinna_reflex1.13389460
95MP0005646_abnormal_pituitary_gland1.13039750
96MP0002733_abnormal_thermal_nociception1.12425397
97MP0000681_abnormal_thyroid_gland1.12191378
98MP0002095_abnormal_skin_pigmentation1.10808701
99MP0003878_abnormal_ear_physiology1.10584808
100MP0005377_hearing/vestibular/ear_phenot1.10584808
101MP0000538_abnormal_urinary_bladder1.09971391
102MP0003115_abnormal_respiratory_system1.09770856
103MP0003122_maternal_imprinting1.09374808
104MP0002928_abnormal_bile_duct1.08991118
105MP0004147_increased_porphyrin_level1.07064705
106MP0002233_abnormal_nose_morphology1.06635869
107MP0002653_abnormal_ependyma_morphology1.06273271
108MP0002163_abnormal_gland_morphology1.05867534
109MP0003942_abnormal_urinary_system1.04691378
110MP0003755_abnormal_palate_morphology1.04075793
111MP0001984_abnormal_olfaction1.02158927
112MP0003950_abnormal_plasma_membrane1.00227351
113MP0006054_spinal_hemorrhage0.99287928
114MP0003633_abnormal_nervous_system0.99201679
115MP0001286_abnormal_eye_development0.98865076
116MP0003123_paternal_imprinting0.98043680
117MP0004381_abnormal_hair_follicle0.97566133
118MP0003119_abnormal_digestive_system0.96408918
119MP0002876_abnormal_thyroid_physiology0.96212689
120MP0002116_abnormal_craniofacial_bone0.96130975
121MP0002109_abnormal_limb_morphology0.96023384
122MP0010678_abnormal_skin_adnexa0.95067777
123MP0004742_abnormal_vestibular_system0.93399474
124MP0004215_abnormal_myocardial_fiber0.92980518
125MP0005670_abnormal_white_adipose0.92601495
126MP0003938_abnormal_ear_development0.92340410
127MP0001929_abnormal_gametogenesis0.90045228
128MP0005508_abnormal_skeleton_morphology0.89854206
129MP0001324_abnormal_eye_pigmentation0.89242740
130MP0000955_abnormal_spinal_cord0.88866217
131MP0001145_abnormal_male_reproductive0.88301769
132MP0000537_abnormal_urethra_morphology0.87803153
133MP0002882_abnormal_neuron_morphology0.86509672
134MP0002282_abnormal_trachea_morphology0.86490794
135MP0005195_abnormal_posterior_eye0.86193539
136MP0002184_abnormal_innervation0.85584556
137MP0006072_abnormal_retinal_apoptosis0.84705772
138MP0000631_abnormal_neuroendocrine_gland0.84569454
139MP0000653_abnormal_sex_gland0.84503810
140MP0000428_abnormal_craniofacial_morphol0.84240045
141MP0005395_other_phenotype0.84174271
142MP0003631_nervous_system_phenotype0.83487965
143MP0010386_abnormal_urinary_bladder0.83270248
144MP0003252_abnormal_bile_duct0.82033029
145MP0000432_abnormal_head_morphology0.82023381
146MP0003137_abnormal_impulse_conducting0.82020461
147MP0009115_abnormal_fat_cell0.81679062
148MP0000230_abnormal_systemic_arterial0.81307053
149MP0002009_preneoplasia0.81226582
150MP0005167_abnormal_blood-brain_barrier0.80885296
151MP0001119_abnormal_female_reproductive0.80805305
152MP0000371_diluted_coat_color0.80754953
153MP0005085_abnormal_gallbladder_physiolo0.80489124
154MP0000613_abnormal_salivary_gland0.79901942
155MP0002229_neurodegeneration0.79341213
156MP0002752_abnormal_somatic_nervous0.79157673
157MP0003698_abnormal_male_reproductive0.78883124
158MP0004134_abnormal_chest_morphology0.78653653
159MP0005448_abnormal_energy_balance0.78251690
160MP0003632_abnormal_nervous_system0.78248763
161MP0003787_abnormal_imprinting0.78172973
162MP0003279_aneurysm0.77934654
163MP0000647_abnormal_sebaceous_gland0.77046041
164MP0000470_abnormal_stomach_morphology0.76444231
165MP0000026_abnormal_inner_ear0.76247442
166MP0003935_abnormal_craniofacial_develop0.74881079
167MP0002751_abnormal_autonomic_nervous0.74694628
168MP0001186_pigmentation_phenotype0.73582721
169MP0003183_abnormal_peptide_metabolism0.73449491
170MP0004885_abnormal_endolymph0.73058832
171MP0005408_hypopigmentation0.72856955
172MP0002697_abnormal_eye_size0.72702109
173MP0003567_abnormal_fetal_cardiomyocyte0.71508617
174MP0002098_abnormal_vibrissa_morphology0.71288477
175MP0005248_abnormal_Harderian_gland0.70328683
176MP0002638_abnormal_pupillary_reflex0.69939546
177MP0002111_abnormal_tail_morphology0.69570848

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)5.30781236
2Genetic anticipation (HP:0003743)5.24477502
3Protruding tongue (HP:0010808)4.52124129
4Progressive cerebellar ataxia (HP:0002073)4.09750202
5Gaze-evoked nystagmus (HP:0000640)3.98034215
6True hermaphroditism (HP:0010459)3.58719767
7Chromsome breakage (HP:0040012)3.53051342
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49718018
9Clumsiness (HP:0002312)3.43787238
10Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.42452504
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.33688140
12Absent/shortened dynein arms (HP:0200106)3.33688140
13Cystic liver disease (HP:0006706)3.29281031
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.17201288
15Abnormality of the renal cortex (HP:0011035)3.16143324
16Fair hair (HP:0002286)3.13282449
17Absent eyebrow (HP:0002223)3.11870947
18Parakeratosis (HP:0001036)2.96309145
19Pancreatic fibrosis (HP:0100732)2.94387817
20Abnormal ciliary motility (HP:0012262)2.94094560
21Broad-based gait (HP:0002136)2.92609476
22Medial flaring of the eyebrow (HP:0010747)2.87475219
23Febrile seizures (HP:0002373)2.85974499
24Congenital stationary night blindness (HP:0007642)2.85946723
25Abnormal respiratory epithelium morphology (HP:0012253)2.85601384
26Abnormal respiratory motile cilium morphology (HP:0005938)2.85601384
27Increased neuronal autofluorescent lipopigment (HP:0002074)2.78810274
28Absent speech (HP:0001344)2.78796323
29Congenital primary aphakia (HP:0007707)2.75105358
30Nephrogenic diabetes insipidus (HP:0009806)2.74024231
31Abnormal respiratory motile cilium physiology (HP:0012261)2.73818676
32Hypoplastic ischia (HP:0003175)2.72736478
33Duplicated collecting system (HP:0000081)2.68819764
34Abnormality of the ischium (HP:0003174)2.68549016
35Birth length less than 3rd percentile (HP:0003561)2.66774999
36Tubular atrophy (HP:0000092)2.65199610
37Follicular hyperkeratosis (HP:0007502)2.64016884
38Gait imbalance (HP:0002141)2.63971730
39Attenuation of retinal blood vessels (HP:0007843)2.62601322
40Abnormality of the renal collecting system (HP:0004742)2.60176744
41Abnormality of incisor morphology (HP:0011063)2.59213714
42Genital tract atresia (HP:0001827)2.56661915
43Embryonal renal neoplasm (HP:0011794)2.56382399
44Vaginal atresia (HP:0000148)2.55796117
45Hypoplasia of the capital femoral epiphysis (HP:0003090)2.55446694
46Generalized hypopigmentation of hair (HP:0011358)2.47178205
47Hypoplastic labia majora (HP:0000059)2.46197784
48Nephroblastoma (Wilms tumor) (HP:0002667)2.43256189
49Widely spaced teeth (HP:0000687)2.41990206
50Inability to walk (HP:0002540)2.41668070
51Furrowed tongue (HP:0000221)2.40219264
52Facial cleft (HP:0002006)2.40030232
53Hypoplastic left heart (HP:0004383)2.38315211
54Congenital hepatic fibrosis (HP:0002612)2.37971104
55Drooling (HP:0002307)2.35877754
56Ectopic kidney (HP:0000086)2.34750543
57Rhinitis (HP:0012384)2.31965632
58Dysmetric saccades (HP:0000641)2.31907945
59Abnormality of the columella (HP:0009929)2.30866167
60White forelock (HP:0002211)2.30055341
61Abnormality of the labia majora (HP:0012881)2.29587426
62Abnormal hair whorl (HP:0010721)2.29223811
63Progressive inability to walk (HP:0002505)2.29145315
64Dialeptic seizures (HP:0011146)2.28830491
65Patchy hypopigmentation of hair (HP:0011365)2.27546268
66Bony spicule pigmentary retinopathy (HP:0007737)2.22456840
67Focal seizures (HP:0007359)2.21387622
68Myelomeningocele (HP:0002475)2.20156984
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.20022107
70Pancreatic cysts (HP:0001737)2.18509780
71Large for gestational age (HP:0001520)2.17888290
72Postaxial foot polydactyly (HP:0001830)2.16331877
73Abnormality of alanine metabolism (HP:0010916)2.15555851
74Hyperalaninemia (HP:0003348)2.15555851
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15555851
76Duplication of thumb phalanx (HP:0009942)2.13172681
77Excessive salivation (HP:0003781)2.12834029
78Nephronophthisis (HP:0000090)2.11863564
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.11818387
80Decreased circulating renin level (HP:0003351)2.11573414
81Anencephaly (HP:0002323)2.11479204
82Supernumerary spleens (HP:0009799)2.11081605
83Abnormality of the preputium (HP:0100587)2.11060140
84Poor coordination (HP:0002370)2.08908986
85Reticulocytopenia (HP:0001896)2.07775150
86Absent hair (HP:0002298)2.07691471
87Tubulointerstitial nephritis (HP:0001970)2.07361361
88Hypothermia (HP:0002045)2.05939629
89Hypoplastic heart (HP:0001961)2.05321704
90Abnormality of the parietal bone (HP:0002696)2.05147724
91Abnormality of chromosome stability (HP:0003220)2.04550157
92Abnormal lung lobation (HP:0002101)2.03471261
93Short middle phalanx of the 5th finger (HP:0004220)2.03085379
94* Preaxial hand polydactyly (HP:0001177)2.02531764
95Cerebellar dysplasia (HP:0007033)2.02144879
96Osteomalacia (HP:0002749)2.00381303
97Occipital encephalocele (HP:0002085)2.00341138
98Type II lissencephaly (HP:0007260)2.00054579
99Cupped ear (HP:0000378)1.98722988
100Renal dysplasia (HP:0000110)1.98347060
101Absent eyelashes (HP:0000561)1.98261828
102Absence seizures (HP:0002121)1.97990958
103Increased cerebral lipofuscin (HP:0011813)1.97906939
104Abnormality of renal resorption (HP:0011038)1.96232614
105Highly arched eyebrow (HP:0002553)1.95542406
106Abnormality of the labia minora (HP:0012880)1.95290733
107Chronic hepatic failure (HP:0100626)1.95097858
108Congenital sensorineural hearing impairment (HP:0008527)1.94200433
109Abnormal drinking behavior (HP:0030082)1.94105181
110Polydipsia (HP:0001959)1.94105181
111Abolished electroretinogram (ERG) (HP:0000550)1.93799041
112Focal motor seizures (HP:0011153)1.93518224
113Lissencephaly (HP:0001339)1.92153430
114Meckel diverticulum (HP:0002245)1.91971937
115Central scotoma (HP:0000603)1.91517371
116Type I transferrin isoform profile (HP:0003642)1.90507638
117Renal cortical cysts (HP:0000803)1.90028312
118Urinary bladder sphincter dysfunction (HP:0002839)1.88029674
119Abnormality of permanent molar morphology (HP:0011071)1.87607381
120Abnormality of the dental root (HP:0006486)1.87607381
121Taurodontia (HP:0000679)1.87607381
122Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.87422850
123Absent epiphyses (HP:0010577)1.87422850
124Small hand (HP:0200055)1.87107768
125Macroglossia (HP:0000158)1.85610330
126Intestinal atresia (HP:0011100)1.85371595
127Stomach cancer (HP:0012126)1.85104145
128Bifid tongue (HP:0010297)1.84974899
129Tented upper lip vermilion (HP:0010804)1.84934021
130Truncal obesity (HP:0001956)1.84578991
131Abnormality of the ileum (HP:0001549)1.83803985
132Medulloblastoma (HP:0002885)1.83369244
133Aplasia/Hypoplasia of the uvula (HP:0010293)1.83171332
134Transposition of the great arteries (HP:0001669)1.83121006
135Abnormal connection of the cardiac segments (HP:0011545)1.83121006
136Abnormal ventriculo-arterial connection (HP:0011563)1.83121006
137Long nose (HP:0003189)1.83040753
138Oligodactyly (hands) (HP:0001180)1.82263324
139Septo-optic dysplasia (HP:0100842)1.80336168
140Abnormality of molar morphology (HP:0011070)1.79661715
141Abnormality of molar (HP:0011077)1.79661715
142Male pseudohermaphroditism (HP:0000037)1.79040973
143Abnormality of the renal medulla (HP:0100957)1.78115194
144Impaired smooth pursuit (HP:0007772)1.77290623
145Sloping forehead (HP:0000340)1.77138814
146Atonic seizures (HP:0010819)1.77016860
147Median cleft lip (HP:0000161)1.76752746
148Abnormality of midbrain morphology (HP:0002418)1.76510330
149Molar tooth sign on MRI (HP:0002419)1.76510330
150Abnormality of dental color (HP:0011073)1.74630447
151Clubbing of toes (HP:0100760)1.74372057
152Abnormality of the dental pulp (HP:0006479)1.73911120
153Bulbous nose (HP:0000414)1.73804587
154Astigmatism (HP:0000483)1.73419930
155Exotropia (HP:0000577)1.73296355
156Abnormality of the pubic bones (HP:0003172)1.72747720
157Dandy-Walker malformation (HP:0001305)1.72416890
158Prostate neoplasm (HP:0100787)1.72054313
159Aplasia/Hypoplasia of the lens (HP:0008063)1.71333844
160Short chin (HP:0000331)1.67491975
161Increased corneal curvature (HP:0100692)1.67489175
162Adrenal hypoplasia (HP:0000835)1.67451238
163Volvulus (HP:0002580)1.66861009
164Oligohydramnios (HP:0001562)1.66645327
165Cutaneous finger syndactyly (HP:0010554)1.65725107
166Hyperphosphatemia (HP:0002905)1.64792932
167Sclerocornea (HP:0000647)1.63557189
168Alveolar cell carcinoma (HP:0006519)1.63417784

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.13826644
2TNIK2.97429170
3CDC72.97352885
4CASK2.43219223
5VRK12.36410313
6STK38L2.16427694
7BMPR1B2.04686135
8MKNK12.02804224
9SRPK12.00267040
10SIK31.99373118
11TXK1.89344546
12MKNK21.75204307
13PLK41.74190707
14YES11.70483563
15PASK1.62652686
16AKT31.62022599
17NTRK31.61435319
18CDK81.59800206
19MAP4K11.48506162
20BMPR21.46738167
21ACVR1B1.46232247
22EIF2AK11.44356983
23INSRR1.44022253
24GRK11.41847648
25TEC1.41288121
26NEK61.41147949
27STK241.39347953
28MAP3K41.36512236
29CAMK1G1.36187784
30EIF2AK21.33726701
31PLK31.33572564
32BRD41.32333953
33EIF2AK31.32242092
34WEE11.29087141
35CHEK21.28679247
36MAPK131.26355987
37ADRBK21.26109602
38TAOK31.23728701
39PNCK1.23382147
40ATR1.22205781
41MST41.21500269
42TTK1.20305624
43MAPKAPK51.19745792
44CAMK1D1.19706550
45MARK31.19199004
46STK161.18468222
47CDK31.17492539
48MELK1.14285089
49IRAK31.14244828
50PLK21.09236415
51CDK71.07377346
52STK391.03376482
53PIK3CA1.03055536
54NLK1.02880971
55MARK11.02235952
56PLK11.01330551
57NUAK11.00126856
58STK30.98843302
59BRAF0.97897979
60LATS10.96727707
61FRK0.92609817
62PAK30.91800831
63MUSK0.89393300
64PINK10.88367125
65RPS6KA50.86505132
66ATM0.86351245
67BCR0.86160702
68CAMKK20.85358994
69PIK3CG0.85112438
70NEK90.85086654
71RPS6KA40.84459921
72DAPK20.83955354
73BRSK20.81814035
74CCNB10.80292985
75AURKB0.80087761
76PBK0.78259109
77CDK120.77943477
78MAPK150.75935018
79SGK20.75453286
80PTK2B0.75415199
81CSNK1A1L0.75337528
82STK380.72475772
83PRKAA20.71516188
84EPHA40.70815951
85AURKA0.70405594
86MAP3K140.69136397
87MAP4K20.68923191
88MAP3K70.68586159
89CHUK0.68218990
90ERBB30.67885475
91OXSR10.66692048
92SIK20.66652488
93NEK20.64872688
94PRKCG0.63831784
95RPS6KB20.63154412
96CLK10.63030974
97TRPM70.62753932
98CSNK1G30.62390862
99CSNK2A10.62107670
100FGFR20.61831341
101WNK40.60981752
102CHEK10.60739857
103GRK70.58775744
104STK100.57949474
105JAK30.57635737
106CSNK2A20.57629473
107ERBB20.57476233
108PKN10.57086444
109PDK30.56871472
110PDK40.56871472
111PDK20.56352630
112WNK10.56329972
113MAP3K120.56283963
114TNK20.55418189
115MAP2K70.55092266
116CAMK10.53326183
117WNK30.53283439
118CAMK40.53151919
119FER0.52714375
120TLK10.52132653
121LIMK10.50864742
122IRAK10.49873973
123SGK10.49168050
124TSSK60.47882305
125CAMK2A0.47640435
126OBSCN0.47513940
127CDK10.47420807
128SGK4940.46969481
129SGK2230.46969481
130STK110.46935807
131BTK0.43432682
132PRKAA10.42983557
133PRKCE0.42910505
134TGFBR10.42631281
135PIM10.42160596
136ADRBK10.41979662
137CSNK1D0.39558087
138NTRK20.38756259
139SGK30.38666803
140RPS6KA30.32619218
141PRKACB0.30800219
142GSK3B0.30232232
143MAP2K10.29468781
144PRKG10.29084950
145MAPKAPK30.28753753
146RPS6KA60.27944937
147PRKACA0.27659724
148PRKCH0.27503962
149EPHA30.27346772
150PDGFRB0.26948659
151MAPK80.25134704
152MARK20.24164586
153DYRK1A0.23375216

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.48934219
2Mismatch repair_Homo sapiens_hsa034303.42974052
3Protein export_Homo sapiens_hsa030603.24871844
4Homologous recombination_Homo sapiens_hsa034403.03142337
5Nicotine addiction_Homo sapiens_hsa050332.94548143
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.85611621
7Fanconi anemia pathway_Homo sapiens_hsa034602.80062235
8RNA polymerase_Homo sapiens_hsa030202.73289485
9Ribosome_Homo sapiens_hsa030102.61621014
10Basal transcription factors_Homo sapiens_hsa030222.57224326
11Cell cycle_Homo sapiens_hsa041102.45799237
12RNA degradation_Homo sapiens_hsa030182.41842415
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41745285
14ABC transporters_Homo sapiens_hsa020102.38108759
15Butanoate metabolism_Homo sapiens_hsa006502.31784623
16Nucleotide excision repair_Homo sapiens_hsa034202.28179536
17Phototransduction_Homo sapiens_hsa047442.26355628
18Base excision repair_Homo sapiens_hsa034102.24342096
19Non-homologous end-joining_Homo sapiens_hsa034502.22477390
20Spliceosome_Homo sapiens_hsa030402.19300781
21Nitrogen metabolism_Homo sapiens_hsa009102.11594018
22Pyrimidine metabolism_Homo sapiens_hsa002402.01218715
23Tryptophan metabolism_Homo sapiens_hsa003801.90685586
24Proteasome_Homo sapiens_hsa030501.88926727
25RNA transport_Homo sapiens_hsa030131.75360405
26Morphine addiction_Homo sapiens_hsa050321.73406939
27Glutamatergic synapse_Homo sapiens_hsa047241.70616791
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68782783
29Lysine degradation_Homo sapiens_hsa003101.66533160
30Steroid biosynthesis_Homo sapiens_hsa001001.65588890
31Circadian entrainment_Homo sapiens_hsa047131.65261711
32Dorso-ventral axis formation_Homo sapiens_hsa043201.60318570
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.52825304
34Histidine metabolism_Homo sapiens_hsa003401.50103975
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.49934283
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46048178
37Selenocompound metabolism_Homo sapiens_hsa004501.45990179
38Calcium signaling pathway_Homo sapiens_hsa040201.45597228
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45462219
40Olfactory transduction_Homo sapiens_hsa047401.43949168
41Purine metabolism_Homo sapiens_hsa002301.38572524
42GABAergic synapse_Homo sapiens_hsa047271.32819533
43Salivary secretion_Homo sapiens_hsa049701.31756235
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31210149
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29867703
46Insulin secretion_Homo sapiens_hsa049111.29290734
47Glycerolipid metabolism_Homo sapiens_hsa005611.27997662
48One carbon pool by folate_Homo sapiens_hsa006701.27155360
49Systemic lupus erythematosus_Homo sapiens_hsa053221.27153737
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23822073
51Ovarian steroidogenesis_Homo sapiens_hsa049131.19149296
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18373617
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16630555
54Vascular smooth muscle contraction_Homo sapiens_hsa042701.16611917
55TGF-beta signaling pathway_Homo sapiens_hsa043501.16444762
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16203101
57Huntingtons disease_Homo sapiens_hsa050161.15389049
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13096877
59p53 signaling pathway_Homo sapiens_hsa041151.12269967
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11049282
61Long-term depression_Homo sapiens_hsa047301.09605675
62Oxidative phosphorylation_Homo sapiens_hsa001901.05764166
63N-Glycan biosynthesis_Homo sapiens_hsa005101.02959987
64Cholinergic synapse_Homo sapiens_hsa047251.01935279
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00139870
66Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00025406
67Gastric acid secretion_Homo sapiens_hsa049710.98089116
68cAMP signaling pathway_Homo sapiens_hsa040240.97634071
69Retinol metabolism_Homo sapiens_hsa008300.95071005
70Hematopoietic cell lineage_Homo sapiens_hsa046400.94129008
71Oxytocin signaling pathway_Homo sapiens_hsa049210.93677856
72Chemical carcinogenesis_Homo sapiens_hsa052040.93671580
73Arachidonic acid metabolism_Homo sapiens_hsa005900.93452857
74Fatty acid biosynthesis_Homo sapiens_hsa000610.93206665
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92869411
76Ether lipid metabolism_Homo sapiens_hsa005650.92606219
77Dopaminergic synapse_Homo sapiens_hsa047280.92529827
78Caffeine metabolism_Homo sapiens_hsa002320.91699633
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89399847
80Herpes simplex infection_Homo sapiens_hsa051680.89120753
81mRNA surveillance pathway_Homo sapiens_hsa030150.84897362
82beta-Alanine metabolism_Homo sapiens_hsa004100.82116419
83Propanoate metabolism_Homo sapiens_hsa006400.80352720
84Type II diabetes mellitus_Homo sapiens_hsa049300.80331723
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80049531
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79440041
87Primary immunodeficiency_Homo sapiens_hsa053400.77952811
88Renin secretion_Homo sapiens_hsa049240.76974045
89Epstein-Barr virus infection_Homo sapiens_hsa051690.76030167
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75357824
91Alcoholism_Homo sapiens_hsa050340.75231254
92Linoleic acid metabolism_Homo sapiens_hsa005910.74404932
93Prostate cancer_Homo sapiens_hsa052150.71451812
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.71250864
95Glutathione metabolism_Homo sapiens_hsa004800.69711918
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69709653
97Autoimmune thyroid disease_Homo sapiens_hsa053200.69627926
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68159268
99Parkinsons disease_Homo sapiens_hsa050120.67560591
100Cocaine addiction_Homo sapiens_hsa050300.66467193
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65874251
102Circadian rhythm_Homo sapiens_hsa047100.65863197
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.65746099
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65431205
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.64680040
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64267365
107Amphetamine addiction_Homo sapiens_hsa050310.63523186
108Pancreatic secretion_Homo sapiens_hsa049720.62564505
109Basal cell carcinoma_Homo sapiens_hsa052170.61948291
110MicroRNAs in cancer_Homo sapiens_hsa052060.60095174
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59714864
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59265815
113Alzheimers disease_Homo sapiens_hsa050100.57777710
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56419885
115HTLV-I infection_Homo sapiens_hsa051660.55927795
116FoxO signaling pathway_Homo sapiens_hsa040680.54893202
117Melanoma_Homo sapiens_hsa052180.54544570
118Wnt signaling pathway_Homo sapiens_hsa043100.54437191
119Axon guidance_Homo sapiens_hsa043600.54222313
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54112838
121Bile secretion_Homo sapiens_hsa049760.54060163
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52857708
123Measles_Homo sapiens_hsa051620.52064491
124Fatty acid elongation_Homo sapiens_hsa000620.51623129
125Viral carcinogenesis_Homo sapiens_hsa052030.50925372
126Choline metabolism in cancer_Homo sapiens_hsa052310.50070861
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48730588
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48559915
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47346085
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47188074
131Pathways in cancer_Homo sapiens_hsa052000.47085142
132Ras signaling pathway_Homo sapiens_hsa040140.46579219
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46432178
134MAPK signaling pathway_Homo sapiens_hsa040100.45816410
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45705778
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45496589
137Hedgehog signaling pathway_Homo sapiens_hsa043400.44957784
138Sphingolipid metabolism_Homo sapiens_hsa006000.44579314
139Peroxisome_Homo sapiens_hsa041460.44527311
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43384389
141Fatty acid degradation_Homo sapiens_hsa000710.43083466
142Small cell lung cancer_Homo sapiens_hsa052220.41638965
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41087449
144Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40996555
145Folate biosynthesis_Homo sapiens_hsa007900.40906634
146Estrogen signaling pathway_Homo sapiens_hsa049150.40541431
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.39927923
148Malaria_Homo sapiens_hsa051440.39439396
149Intestinal immune network for IgA production_Homo sapiens_hsa046720.38671409
150Serotonergic synapse_Homo sapiens_hsa047260.38615658
151Mineral absorption_Homo sapiens_hsa049780.38522340
152Sulfur metabolism_Homo sapiens_hsa009200.38407966
153Hepatitis B_Homo sapiens_hsa051610.38016184
154Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37774639
155Platelet activation_Homo sapiens_hsa046110.36898200
156Metabolic pathways_Homo sapiens_hsa011000.35993051
157Taste transduction_Homo sapiens_hsa047420.35820964
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35377430
159PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34009740
160Arginine and proline metabolism_Homo sapiens_hsa003300.33547038
161Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33222019
162Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33014309
163Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32916230
164ECM-receptor interaction_Homo sapiens_hsa045120.32367377
165Hippo signaling pathway_Homo sapiens_hsa043900.29340870
166Phagosome_Homo sapiens_hsa041450.26701834
167Oocyte meiosis_Homo sapiens_hsa041140.26657997
168Vitamin digestion and absorption_Homo sapiens_hsa049770.25321528
169Thyroid cancer_Homo sapiens_hsa052160.24100406
170Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23924174
171Adherens junction_Homo sapiens_hsa045200.22179016
172Rheumatoid arthritis_Homo sapiens_hsa053230.20775319

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »