MIS18A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.95619953
2DNA strand elongation involved in DNA replication (GO:0006271)4.81083248
3telomere maintenance via semi-conservative replication (GO:0032201)4.69709136
4protein localization to kinetochore (GO:0034501)4.68379905
5establishment of integrated proviral latency (GO:0075713)4.64214301
6DNA strand elongation (GO:0022616)4.58670492
7DNA replication checkpoint (GO:0000076)4.57654130
8DNA deamination (GO:0045006)4.57379564
9DNA replication initiation (GO:0006270)4.51699018
10* CENP-A containing nucleosome assembly (GO:0034080)4.40742280
11metaphase plate congression (GO:0051310)4.36286808
12ribosomal small subunit assembly (GO:0000028)4.35144276
13protein localization to chromosome, centromeric region (GO:0071459)4.33600716
14telomere maintenance via recombination (GO:0000722)4.31623556
15* chromatin remodeling at centromere (GO:0031055)4.27160662
16kinetochore organization (GO:0051383)4.22367105
17mitotic recombination (GO:0006312)4.12840413
18attachment of spindle microtubules to kinetochore (GO:0008608)4.11352162
19kinetochore assembly (GO:0051382)3.96421999
20establishment of chromosome localization (GO:0051303)3.95866168
21* DNA replication-independent nucleosome organization (GO:0034724)3.94596328
22* DNA replication-independent nucleosome assembly (GO:0006336)3.94596328
23maturation of SSU-rRNA (GO:0030490)3.92063360
24regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.89415955
25mitotic chromosome condensation (GO:0007076)3.87284931
26regulation of spindle organization (GO:0090224)3.85702181
27DNA unwinding involved in DNA replication (GO:0006268)3.84783979
28mitotic sister chromatid segregation (GO:0000070)3.75000285
29telomere maintenance via telomere lengthening (GO:0010833)3.71861497
30DNA ligation (GO:0006266)3.70875741
31nucleobase biosynthetic process (GO:0046112)3.61695866
32nucleotide-excision repair, DNA gap filling (GO:0006297)3.61574753
33purine nucleobase biosynthetic process (GO:0009113)3.60839604
34mitotic nuclear envelope disassembly (GO:0007077)3.59549978
35viral transcription (GO:0019083)3.57029215
36* histone exchange (GO:0043486)3.56641929
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.56181421
38establishment of viral latency (GO:0019043)3.53250946
39translational termination (GO:0006415)3.52297282
40ribosomal small subunit biogenesis (GO:0042274)3.50917658
41formation of translation preinitiation complex (GO:0001731)3.50111366
42meiotic chromosome segregation (GO:0045132)3.42672693
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39707828
44ribosome biogenesis (GO:0042254)3.38646909
45IMP biosynthetic process (GO:0006188)3.38593050
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38292817
47chaperone-mediated protein transport (GO:0072321)3.35923864
48ribonucleoprotein complex biogenesis (GO:0022613)3.34394857
49regulation of mitochondrial translation (GO:0070129)3.33581044
50sister chromatid segregation (GO:0000819)3.32909707
51nuclear envelope disassembly (GO:0051081)3.32585496
52membrane disassembly (GO:0030397)3.32585496
53regulation of double-strand break repair via homologous recombination (GO:0010569)3.30657639
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.29314181
55proteasome assembly (GO:0043248)3.29173150
56spindle checkpoint (GO:0031577)3.28492409
57regulation of helicase activity (GO:0051095)3.27838056
58establishment of protein localization to mitochondrial membrane (GO:0090151)3.23608191
59DNA replication-dependent nucleosome assembly (GO:0006335)3.21808132
60DNA replication-dependent nucleosome organization (GO:0034723)3.21808132
61maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.21187455
62protein K6-linked ubiquitination (GO:0085020)3.20409773
63L-serine metabolic process (GO:0006563)3.19838021
64ribosomal large subunit biogenesis (GO:0042273)3.19721961
65translational elongation (GO:0006414)3.19719118
66translational initiation (GO:0006413)3.19593574
67regulation of centriole replication (GO:0046599)3.18161030
68replication fork processing (GO:0031297)3.17559908
69regulation of mitotic sister chromatid separation (GO:0010965)3.17259976
70regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16019081
71regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15379672
72regulation of mitotic spindle checkpoint (GO:1903504)3.15379672
73rRNA processing (GO:0006364)3.14498571
74spliceosomal snRNP assembly (GO:0000387)3.13642762
75protein localization to chromosome (GO:0034502)3.13270992
76transcription-coupled nucleotide-excision repair (GO:0006283)3.12874532
77pseudouridine synthesis (GO:0001522)3.12433642
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12193172
79DNA topological change (GO:0006265)3.10328973
80negative regulation of chromosome segregation (GO:0051985)3.10109109
81negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09674352
82negative regulation of sister chromatid segregation (GO:0033046)3.09582260
83negative regulation of mitotic sister chromatid separation (GO:2000816)3.09582260
84negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09582260
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09582260
86DNA damage response, detection of DNA damage (GO:0042769)3.09041955
87regulation of chromosome segregation (GO:0051983)3.08368770
88spindle assembly checkpoint (GO:0071173)3.05763613
89heterochromatin organization (GO:0070828)3.05626653
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04508461
91rRNA metabolic process (GO:0016072)3.04391247
92SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04270426
93mitotic G2/M transition checkpoint (GO:0044818)3.02774347
94regulation of mitotic spindle organization (GO:0060236)3.02372149
95somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02229752
96somatic hypermutation of immunoglobulin genes (GO:0016446)3.02229752
97ribosome assembly (GO:0042255)3.02154447
98rRNA modification (GO:0000154)3.01944359
99positive regulation of chromosome segregation (GO:0051984)3.01389136
100IMP metabolic process (GO:0046040)3.01237906
101non-recombinational repair (GO:0000726)3.01029018
102double-strand break repair via nonhomologous end joining (GO:0006303)3.01029018
103mitotic spindle assembly checkpoint (GO:0007094)3.00836503
104nuclear pore complex assembly (GO:0051292)3.00835119
105regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99696005
106cell cycle G1/S phase transition (GO:0044843)2.99535183
107G1/S transition of mitotic cell cycle (GO:0000082)2.99535183
108regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99393275
109* ATP-dependent chromatin remodeling (GO:0043044)2.99169772
110nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99000647
111* chromosome segregation (GO:0007059)2.98770964
112mitotic sister chromatid cohesion (GO:0007064)2.98151627
113negative regulation of mitosis (GO:0045839)2.97065019
114cotranslational protein targeting to membrane (GO:0006613)2.96656656
115transcription elongation from RNA polymerase III promoter (GO:0006385)2.94741031
116termination of RNA polymerase III transcription (GO:0006386)2.94741031
117* chromatin assembly or disassembly (GO:0006333)2.94233727
118mitotic spindle checkpoint (GO:0071174)2.93683416
119protein targeting to ER (GO:0045047)2.93662973
120spliceosomal complex assembly (GO:0000245)2.92843168
121telomere maintenance (GO:0000723)2.91862438
122telomere organization (GO:0032200)2.91599970
123exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87001425
124negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83304525
125negative regulation of ligase activity (GO:0051352)2.83304525
126mitotic cell cycle (GO:0000278)2.82020040
127regulation of mitotic sister chromatid segregation (GO:0033047)2.81375325
128regulation of sister chromatid segregation (GO:0033045)2.81375325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.35951226
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.66648370
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.00128482
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.84585213
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.56098354
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49157813
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31447736
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.97118489
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.93670214
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.87100394
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.74597700
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73809240
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68339846
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66827796
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64884175
16VDR_23849224_ChIP-Seq_CD4+_Human2.36197570
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33011168
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32400236
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29564494
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25288078
21XRN2_22483619_ChIP-Seq_HELA_Human2.22402359
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22217926
23AR_21909140_ChIP-Seq_LNCAP_Human2.14229178
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.13786199
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11745694
26FOXP3_21729870_ChIP-Seq_TREG_Human2.04849265
27E2F1_21310950_ChIP-Seq_MCF-7_Human2.00902937
28DCP1A_22483619_ChIP-Seq_HELA_Human2.00310360
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99387065
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93742923
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88384690
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87525386
33GABP_19822575_ChIP-Seq_HepG2_Human1.86725029
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86001275
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81417470
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79491033
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79327552
38TTF2_22483619_ChIP-Seq_HELA_Human1.78298660
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75445235
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71604076
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68717511
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63643490
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63409911
44ELK1_19687146_ChIP-ChIP_HELA_Human1.62385465
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60635199
46CIITA_25753668_ChIP-Seq_RAJI_Human1.60183772
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.57041764
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56374650
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53471395
50MYC_22102868_ChIP-Seq_BL_Human1.52808493
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.49953662
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47153499
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46661981
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46370089
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.46065746
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.45293479
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45160121
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41917874
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40921288
60KDM5A_27292631_Chip-Seq_BREAST_Human1.38756937
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38347972
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.35603487
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32222404
64SPI1_23547873_ChIP-Seq_NB4_Human1.25736809
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25581568
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21995193
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15965159
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.15628340
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15624583
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.14695491
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13022682
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12727932
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12727932
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12727932
75MYC_18940864_ChIP-ChIP_HL60_Human1.11995207
76EWS_26573619_Chip-Seq_HEK293_Human1.11123581
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.10198188
78VDR_21846776_ChIP-Seq_THP-1_Human1.09205530
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09170882
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07282107
81TFEB_21752829_ChIP-Seq_HELA_Human1.06420599
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04009818
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02930796
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02333849
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02050589
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01417288
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00441749
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99153964
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98539427
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95234576
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94356169
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93823597
93MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92270179
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92267444
95IRF8_21731497_ChIP-ChIP_J774_Mouse0.91232735
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90109867
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86391312
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84216134
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82430303
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.82225313
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82071239
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82066799
103MYB_26560356_Chip-Seq_TH2_Human0.81853029
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80842794
105STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80099485
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79459420
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.79012445
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78720636
109FUS_26573619_Chip-Seq_HEK293_Human0.78704377
110MYB_26560356_Chip-Seq_TH1_Human0.77370133
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77348927
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76551275
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76218000
114IRF1_19129219_ChIP-ChIP_H3396_Human0.75471046
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75273634
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75067968
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.74680956
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74442328
119RBPJ_22232070_ChIP-Seq_NCS_Mouse0.73561527
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73204271
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71564097
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.69032110

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.86076615
2MP0010094_abnormal_chromosome_stability4.71151453
3MP0003111_abnormal_nucleus_morphology4.50709174
4MP0004957_abnormal_blastocyst_morpholog4.26778952
5MP0003077_abnormal_cell_cycle4.02730396
6MP0008057_abnormal_DNA_replication3.59525657
7MP0008058_abnormal_DNA_repair3.34746612
8MP0008007_abnormal_cellular_replicative2.98787827
9MP0002396_abnormal_hematopoietic_system2.83279279
10MP0008932_abnormal_embryonic_tissue2.45322875
11MP0003941_abnormal_skin_development2.19303584
12MP0008877_abnormal_DNA_methylation2.14136547
13MP0000490_abnormal_crypts_of2.08179389
14MP0009697_abnormal_copulation2.04217976
15MP0000350_abnormal_cell_proliferation2.00519287
16MP0003718_maternal_effect1.98088658
17MP0003890_abnormal_embryonic-extraembry1.94787778
18MP0001730_embryonic_growth_arrest1.93441904
19MP0009333_abnormal_splenocyte_physiolog1.91437059
20MP0003763_abnormal_thymus_physiology1.88804671
21MP0010030_abnormal_orbit_morphology1.85861878
22MP0003786_premature_aging1.81673183
23MP0001545_abnormal_hematopoietic_system1.78511208
24MP0005397_hematopoietic_system_phenotyp1.78511208
25MP0004808_abnormal_hematopoietic_stem1.73112219
26MP0010307_abnormal_tumor_latency1.71553019
27MP0003123_paternal_imprinting1.70769121
28MP0001835_abnormal_antigen_presentation1.66198145
29MP0002398_abnormal_bone_marrow1.61751086
30MP0002019_abnormal_tumor_incidence1.61500834
31MP0006035_abnormal_mitochondrial_morpho1.60784668
32MP0003136_yellow_coat_color1.57625506
33MP0008789_abnormal_olfactory_epithelium1.56556693
34MP0006292_abnormal_olfactory_placode1.50195482
35MP0002938_white_spotting1.47506724
36MP0005671_abnormal_response_to1.44304105
37MP0000313_abnormal_cell_death1.44057508
38MP0001188_hyperpigmentation1.42610083
39MP0003937_abnormal_limbs/digits/tail_de1.42388639
40MP0009672_abnormal_birth_weight1.42140564
41MP0005380_embryogenesis_phenotype1.40584707
42MP0001672_abnormal_embryogenesis/_devel1.40584707
43MP0002722_abnormal_immune_system1.40161503
44MP0001697_abnormal_embryo_size1.39529283
45MP0000689_abnormal_spleen_morphology1.39330961
46MP0000372_irregular_coat_pigmentation1.35265696
47MP0000703_abnormal_thymus_morphology1.34008818
48MP0002080_prenatal_lethality1.31857377
49MP0001529_abnormal_vocalization1.27422010
50MP0010352_gastrointestinal_tract_polyps1.25147356
51MP0003567_abnormal_fetal_cardiomyocyte1.25116150
52MP0003984_embryonic_growth_retardation1.24143747
53MP0002429_abnormal_blood_cell1.24125557
54MP0005394_taste/olfaction_phenotype1.22833455
55MP0005499_abnormal_olfactory_system1.22833455
56MP0000716_abnormal_immune_system1.22256505
57MP0005174_abnormal_tail_pigmentation1.19822613
58MP0002088_abnormal_embryonic_growth/wei1.19738444
59MP0002210_abnormal_sex_determination1.19363995
60MP0006054_spinal_hemorrhage1.19259674
61MP0001800_abnormal_humoral_immune1.18984475
62MP0000685_abnormal_immune_system1.18745607
63MP0002420_abnormal_adaptive_immunity1.16657029
64MP0009785_altered_susceptibility_to1.15945200
65MP0001819_abnormal_immune_cell1.14997402
66MP0002085_abnormal_embryonic_tissue1.12395050
67MP0002452_abnormal_antigen_presenting1.12246311
68MP0001286_abnormal_eye_development1.09602140
69MP0002697_abnormal_eye_size1.09114737
70MP0003119_abnormal_digestive_system1.08992246
71MP0002086_abnormal_extraembryonic_tissu1.08303366
72MP0002102_abnormal_ear_morphology1.08133130
73MP0002132_abnormal_respiratory_system1.07272846
74MP0001929_abnormal_gametogenesis1.06279696
75MP0003315_abnormal_perineum_morphology1.06028651
76MP0002006_tumorigenesis1.05162214
77MP0002233_abnormal_nose_morphology1.05146539
78MP0001853_heart_inflammation1.04064706
79MP0000049_abnormal_middle_ear1.03214900
80MP0001119_abnormal_female_reproductive1.03163196
81MP0002723_abnormal_immune_serum1.02900688
82MP0000858_altered_metastatic_potential1.01828771
83MP0001145_abnormal_male_reproductive1.01546375
84MP0005075_abnormal_melanosome_morpholog1.01222127
85MP0002166_altered_tumor_susceptibility1.00627187
86MP0005025_abnormal_response_to1.00139989
87MP0005000_abnormal_immune_tolerance0.99546483
88MP0002111_abnormal_tail_morphology0.98895757
89MP0008995_early_reproductive_senescence0.96013155
90MP0002405_respiratory_system_inflammati0.95762568
91MP0000653_abnormal_sex_gland0.94639002
92MP0002095_abnormal_skin_pigmentation0.94020018
93MP0006072_abnormal_retinal_apoptosis0.93448958
94MP0002234_abnormal_pharynx_morphology0.93198834
95MP0003436_decreased_susceptibility_to0.92105625
96MP0002084_abnormal_developmental_patter0.91902310
97MP0009379_abnormal_foot_pigmentation0.88858308
98MP0000015_abnormal_ear_pigmentation0.88779468
99MP0000465_gastrointestinal_hemorrhage0.88074405
100MP0003186_abnormal_redox_activity0.84348419
101MP0004147_increased_porphyrin_level0.83972571
102MP0003656_abnormal_erythrocyte_physiolo0.81839937
103MP0003698_abnormal_male_reproductive0.80613244
104MP0008260_abnormal_autophagy0.80474249
105MP0005395_other_phenotype0.79839018
106MP0002148_abnormal_hypersensitivity_rea0.79633204
107MP0009278_abnormal_bone_marrow0.79468009
108MP0010155_abnormal_intestine_physiology0.79361673
109MP0004197_abnormal_fetal_growth/weight/0.78964104
110MP0000358_abnormal_cell_content/0.77355338
111MP0005501_abnormal_skin_physiology0.76828592
112MP0001764_abnormal_homeostasis0.75846427
113MP0003861_abnormal_nervous_system0.75003155
114MP0003699_abnormal_female_reproductive0.74891018
115MP0002161_abnormal_fertility/fecundity0.74623401
116MP0001293_anophthalmia0.74399103
117MP0002419_abnormal_innate_immunity0.73338654
118MP0009703_decreased_birth_body0.73254077
119MP0000631_abnormal_neuroendocrine_gland0.72666685
120MP0002163_abnormal_gland_morphology0.72148728
121MP0000647_abnormal_sebaceous_gland0.72066906
122MP0002160_abnormal_reproductive_system0.71402909
123MP0003121_genomic_imprinting0.71026425
124MP0000537_abnormal_urethra_morphology0.70964944
125MP0005389_reproductive_system_phenotype0.70215690
126MP0005384_cellular_phenotype0.69729080
127MP0006036_abnormal_mitochondrial_physio0.69267710
128MP0000566_synostosis0.68298541
129MP0005621_abnormal_cell_physiology0.68155726
130MP0003448_altered_tumor_morphology0.67679351
131MP0005464_abnormal_platelet_physiology0.66819730
132MP0004133_heterotaxia0.66317709
133MP0002751_abnormal_autonomic_nervous0.66310919
134MP0003755_abnormal_palate_morphology0.65425691
135MP0002092_abnormal_eye_morphology0.64111889
136MP0003806_abnormal_nucleotide_metabolis0.63881557
137MP0001346_abnormal_lacrimal_gland0.63689552
138MP0002796_impaired_skin_barrier0.63633190
139MP0000477_abnormal_intestine_morphology0.61842479
140MP0003221_abnormal_cardiomyocyte_apopto0.61569518
141MP0001727_abnormal_embryo_implantation0.61125354
142MP0001915_intracranial_hemorrhage0.59875665
143MP0003943_abnormal_hepatobiliary_system0.59686970
144MP0003787_abnormal_imprinting0.57551560
145MP0003938_abnormal_ear_development0.56925984
146MP0005391_vision/eye_phenotype0.56040038
147MP0000428_abnormal_craniofacial_morphol0.55795746
148MP0001881_abnormal_mammary_gland0.55153488

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.46118360
2Abnormal number of erythroid precursors (HP:0012131)4.85153133
3Abnormality of cells of the erythroid lineage (HP:0012130)4.81495404
4Reticulocytopenia (HP:0001896)4.42142648
5Chromsome breakage (HP:0040012)4.11172032
6Breast hypoplasia (HP:0003187)3.91385226
7Aplastic anemia (HP:0001915)3.89608405
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.85858804
9Acute necrotizing encephalopathy (HP:0006965)3.61211421
10Oral leukoplakia (HP:0002745)3.58958483
11Abnormality of the labia minora (HP:0012880)3.54614856
12Patellar aplasia (HP:0006443)3.38676539
13Abnormality of chromosome stability (HP:0003220)3.36914691
14Acute encephalopathy (HP:0006846)3.36493797
15Meckel diverticulum (HP:0002245)3.33011702
16Abnormality of the preputium (HP:0100587)3.30728278
17Abnormal mitochondria in muscle tissue (HP:0008316)3.27256029
18Abnormality of the ileum (HP:0001549)3.18046696
19Aplasia/Hypoplasia of the patella (HP:0006498)3.15845803
20Colon cancer (HP:0003003)3.10002787
21Myelodysplasia (HP:0002863)3.03150956
22Thrombocytosis (HP:0001894)2.99893064
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.98651400
24Increased hepatocellular lipid droplets (HP:0006565)2.96593497
25Increased CSF lactate (HP:0002490)2.95332984
26Mitochondrial inheritance (HP:0001427)2.93416395
27Carpal bone hypoplasia (HP:0001498)2.91560721
28Pallor (HP:0000980)2.90097491
29Macrocytic anemia (HP:0001972)2.88953211
30Rough bone trabeculation (HP:0100670)2.87615239
31Microretrognathia (HP:0000308)2.85758257
32Duodenal stenosis (HP:0100867)2.83433704
33Small intestinal stenosis (HP:0012848)2.83433704
34Progressive macrocephaly (HP:0004481)2.77277802
35Bone marrow hypocellularity (HP:0005528)2.72141031
36Abnormality of the anterior horn cell (HP:0006802)2.71338078
37Degeneration of anterior horn cells (HP:0002398)2.71338078
38Lipid accumulation in hepatocytes (HP:0006561)2.66078289
39Impulsivity (HP:0100710)2.65962112
40Selective tooth agenesis (HP:0001592)2.65451660
41Absent thumb (HP:0009777)2.64603991
42Cerebral edema (HP:0002181)2.62701463
43IgM deficiency (HP:0002850)2.62240880
44Agnosia (HP:0010524)2.62003188
45Hepatocellular necrosis (HP:0001404)2.57905033
46Embryonal renal neoplasm (HP:0011794)2.51645935
47Increased serum pyruvate (HP:0003542)2.50472262
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.45964327
49Premature graying of hair (HP:0002216)2.44618118
50Abnormal lung lobation (HP:0002101)2.42314611
51Septo-optic dysplasia (HP:0100842)2.38786445
5211 pairs of ribs (HP:0000878)2.38457912
53Muscle fiber atrophy (HP:0100295)2.38012629
54Microvesicular hepatic steatosis (HP:0001414)2.36790370
55Type I transferrin isoform profile (HP:0003642)2.36266753
56Abnormality of glycolysis (HP:0004366)2.35931752
57Multiple enchondromatosis (HP:0005701)2.33939232
58Type 2 muscle fiber atrophy (HP:0003554)2.29474467
59Sloping forehead (HP:0000340)2.28780640
60Hepatic necrosis (HP:0002605)2.27606083
61Lymphoma (HP:0002665)2.26097291
62Abnormality of the duodenum (HP:0002246)2.24681702
63Increased serum lactate (HP:0002151)2.23241632
64Cellular immunodeficiency (HP:0005374)2.22545116
65Reduced antithrombin III activity (HP:0001976)2.22497875
66Premature ovarian failure (HP:0008209)2.22054211
67Abnormal spermatogenesis (HP:0008669)2.21397513
68Cerebral hypomyelination (HP:0006808)2.19936744
69Abnormality of the heme biosynthetic pathway (HP:0010472)2.19908408
70Medulloblastoma (HP:0002885)2.19580590
71Renal Fanconi syndrome (HP:0001994)2.19504447
72Short middle phalanx of the 5th finger (HP:0004220)2.19435869
73Petechiae (HP:0000967)2.19357859
74Clubbing of toes (HP:0100760)2.19059448
75Absent radius (HP:0003974)2.18685500
76Tracheoesophageal fistula (HP:0002575)2.18516207
77Neoplasm of the pancreas (HP:0002894)2.16037697
78Cleft eyelid (HP:0000625)2.15781783
79Increased nuchal translucency (HP:0010880)2.13974048
80Triphalangeal thumb (HP:0001199)2.13413038
81Abnormal trabecular bone morphology (HP:0100671)2.12974554
82Pancytopenia (HP:0001876)2.12962709
83Hyperglycinemia (HP:0002154)2.09697510
84Volvulus (HP:0002580)2.09657099
85Slender long bone (HP:0003100)2.04535950
86Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03290949
87IgG deficiency (HP:0004315)2.03045272
88Poikiloderma (HP:0001029)2.01499632
89Absent septum pellucidum (HP:0001331)2.01038105
90Horseshoe kidney (HP:0000085)2.01016886
91Abnormal number of incisors (HP:0011064)2.00529557
92Absent forearm bone (HP:0003953)2.00225650
93Aplasia involving forearm bones (HP:0009822)2.00225650
94Respiratory difficulties (HP:0002880)1.98769494
95Cortical dysplasia (HP:0002539)1.98543381
96Lactic acidosis (HP:0003128)1.98419097
97Supernumerary spleens (HP:0009799)1.97170027
98Pulmonary fibrosis (HP:0002206)1.96776298
99Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95774011
100Abnormality of serum amino acid levels (HP:0003112)1.94585700
101Abnormality of DNA repair (HP:0003254)1.94409369
102Chronic otitis media (HP:0000389)1.94377334
103Facial cleft (HP:0002006)1.93112397
104Abnormality of the carotid arteries (HP:0005344)1.92893372
105Abnormality of methionine metabolism (HP:0010901)1.92323564
106Ectopic kidney (HP:0000086)1.92061630
107Secondary amenorrhea (HP:0000869)1.90619992
108Basal cell carcinoma (HP:0002671)1.90365267
109Duplication of thumb phalanx (HP:0009942)1.89983741
110Abnormality of the septum pellucidum (HP:0007375)1.89415623
111Trismus (HP:0000211)1.89115289
112Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88625134
113Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88625134
114Poor head control (HP:0002421)1.88429209
115Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87664558
116Leukodystrophy (HP:0002415)1.87365363
117Facial hemangioma (HP:0000329)1.87046363
118Exercise intolerance (HP:0003546)1.86614707
119Ependymoma (HP:0002888)1.85143263
120Rhabdomyosarcoma (HP:0002859)1.84697475
121Stenosis of the external auditory canal (HP:0000402)1.84074640
122Squamous cell carcinoma (HP:0002860)1.83829520
123Elevated erythrocyte sedimentation rate (HP:0003565)1.83455659
124Atresia of the external auditory canal (HP:0000413)1.83231409
125Abnormality of cochlea (HP:0000375)1.81818943
126Acute myeloid leukemia (HP:0004808)1.81632541
127Duplicated collecting system (HP:0000081)1.81476362
128Megaloblastic anemia (HP:0001889)1.80201947
129Abnormality of alanine metabolism (HP:0010916)1.79816760
130Hyperalaninemia (HP:0003348)1.79816760
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79816760
132Entropion (HP:0000621)1.79591560
133Prominent nose (HP:0000448)1.79433741
134Short thumb (HP:0009778)1.79018500
135Overlapping toe (HP:0001845)1.78249194
136Nephroblastoma (Wilms tumor) (HP:0002667)1.77424406
137Aplasia/Hypoplasia of the thymus (HP:0010515)1.76995009
138Exertional dyspnea (HP:0002875)1.75447097
139Cafe-au-lait spot (HP:0000957)1.75394616
140Leukopenia (HP:0001882)1.75123811
141Choanal atresia (HP:0000453)1.75056304
142Neoplasm of the colon (HP:0100273)1.74502508
143Rectovaginal fistula (HP:0000143)1.73755227
144Rectal fistula (HP:0100590)1.73755227
145Optic nerve coloboma (HP:0000588)1.73577683
146Progressive muscle weakness (HP:0003323)1.73006135
147Recurrent abscess formation (HP:0002722)1.72469138
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.71886291
149Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71141382
150Abnormal protein N-linked glycosylation (HP:0012347)1.71141382
151Abnormal protein glycosylation (HP:0012346)1.71141382
152Abnormal glycosylation (HP:0012345)1.71141382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.03106093
2WEE14.33445149
3VRK23.78614116
4CDC73.68037171
5EIF2AK13.59255989
6NEK23.04505094
7ACVR1B2.71332563
8NME22.70781158
9BRSK22.52914473
10PLK42.38304023
11STK162.38177673
12TTK2.26827559
13SRPK12.22747863
14TRIM282.05267657
15VRK12.04577546
16PLK12.01340668
17MST41.90390714
18EIF2AK31.86295564
19TAF11.84742734
20DYRK31.83869894
21AURKB1.77782360
22RPS6KA41.70540537
23CCNB11.69986439
24MKNK11.65193582
25NEK11.63155858
26BRSK11.60497644
27TNIK1.56984339
28CDK71.55144634
29MAP4K11.54460951
30TLK11.53803904
31NUAK11.52661709
32ATR1.46228368
33TESK21.42420153
34MKNK21.41069415
35CHEK21.40266118
36STK101.38570673
37CDK41.28575707
38AURKA1.25813223
39CDK81.25317039
40PIM21.21564382
41PLK31.20569174
42MAP3K81.19971905
43TSSK61.17840073
44TEC1.13587908
45PDK21.10815515
46RPS6KB21.08890920
47STK41.06539247
48TGFBR11.03729737
49BMPR1B1.00910210
50KDR0.99492236
51MELK0.98681873
52PIM10.97878677
53PASK0.95114777
54WNK30.93930376
55CHEK10.92583640
56FLT30.92491989
57EIF2AK20.91032989
58CDK190.90589355
59TXK0.89578724
60KIT0.88854420
61IRAK40.84978845
62BRAF0.83105381
63BCKDK0.82331385
64PAK40.78756990
65BTK0.77469731
66PNCK0.77286082
67MAP4K20.76446947
68TYK20.71903483
69SCYL20.71597459
70ZAP700.71074818
71ZAK0.69668786
72EEF2K0.68922320
73ALK0.68875454
74ATM0.66395238
75CSNK1G10.65032828
76NLK0.63723660
77CDK20.61856148
78BLK0.61426850
79PAK10.60762461
80CSNK2A10.60748686
81MAP2K30.60530666
82MAP3K110.57433262
83JAK30.57379401
84CSNK1E0.56440600
85CDK60.53915870
86CSNK2A20.52189778
87CSF1R0.51399145
88BRD40.51309290
89STK30.50683766
90RPS6KA50.49161178
91ARAF0.49155342
92CSNK1G20.49051609
93CLK10.48636011
94BCR0.47758626
95CDK10.46474438
96MAP3K60.46031256
97CDK30.44550694
98LRRK20.43099425
99ABL20.41665062
100PRKDC0.41603647
101PLK20.40903561
102DYRK20.40151987
103IKBKB0.39060491
104RAF10.39006886
105CSNK1A1L0.38363325
106LYN0.38228753
107CDK11A0.38127513
108MAPKAPK50.37913678
109STK38L0.36950712
110CDK180.36941314
111SYK0.36807460
112MAPK110.36224848
113MAP3K90.35415513
114CDK150.34497618
115GRK60.34387312
116CDK140.34194764
117NME10.33537447
118MARK30.33326644
119ERBB40.33210492
120MAP3K100.32620880
121SMG10.31315943
122NEK90.31237625
123MOS0.30608637
124BMPR20.30237266
125PBK0.30014540
126FGFR10.29403977
127YES10.28530176
128TAOK20.27091190
129CSNK1G30.27083709
130PRKCI0.26150660
131STK240.26019180
132TESK10.25853567
133EPHA20.25622067
134CDK90.25011678
135OXSR10.24657042
136CDK120.23705577
137DAPK10.23638849

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.11517529
2Mismatch repair_Homo sapiens_hsa034304.15602764
3Ribosome_Homo sapiens_hsa030103.50914522
4RNA polymerase_Homo sapiens_hsa030203.37776730
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37012817
6Homologous recombination_Homo sapiens_hsa034403.31108987
7Base excision repair_Homo sapiens_hsa034103.30936253
8Proteasome_Homo sapiens_hsa030503.12322803
9Spliceosome_Homo sapiens_hsa030403.09281041
10Cell cycle_Homo sapiens_hsa041102.89295215
11Nucleotide excision repair_Homo sapiens_hsa034202.83141890
12RNA transport_Homo sapiens_hsa030132.77556815
13Pyrimidine metabolism_Homo sapiens_hsa002402.58441933
14Fanconi anemia pathway_Homo sapiens_hsa034602.40602447
15Oxidative phosphorylation_Homo sapiens_hsa001902.21103927
16Basal transcription factors_Homo sapiens_hsa030222.05396741
17RNA degradation_Homo sapiens_hsa030181.94102281
18Non-homologous end-joining_Homo sapiens_hsa034501.88032439
19One carbon pool by folate_Homo sapiens_hsa006701.80472807
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72541177
21p53 signaling pathway_Homo sapiens_hsa041151.71527591
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67075491
23mRNA surveillance pathway_Homo sapiens_hsa030151.39140689
24Purine metabolism_Homo sapiens_hsa002301.38558160
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36971419
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34966179
27Pyruvate metabolism_Homo sapiens_hsa006201.34955687
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32976604
29Herpes simplex infection_Homo sapiens_hsa051681.24260449
30Epstein-Barr virus infection_Homo sapiens_hsa051691.22113163
31Alzheimers disease_Homo sapiens_hsa050101.21929643
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20100812
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19181063
34Primary immunodeficiency_Homo sapiens_hsa053401.10909585
35Propanoate metabolism_Homo sapiens_hsa006401.05261171
36Fatty acid elongation_Homo sapiens_hsa000621.02670872
37Vitamin B6 metabolism_Homo sapiens_hsa007501.01740444
38Antigen processing and presentation_Homo sapiens_hsa046121.01491702
39Folate biosynthesis_Homo sapiens_hsa007900.99827188
40Systemic lupus erythematosus_Homo sapiens_hsa053220.98760579
41Oocyte meiosis_Homo sapiens_hsa041140.96453771
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95861181
43Protein export_Homo sapiens_hsa030600.92725229
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92324734
45Carbon metabolism_Homo sapiens_hsa012000.91439172
46Pentose phosphate pathway_Homo sapiens_hsa000300.86987087
47Steroid biosynthesis_Homo sapiens_hsa001000.84528623
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82462645
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81906559
50Viral carcinogenesis_Homo sapiens_hsa052030.78245714
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75402882
52Measles_Homo sapiens_hsa051620.75057137
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.74837449
54HTLV-I infection_Homo sapiens_hsa051660.73838223
55Sulfur relay system_Homo sapiens_hsa041220.72085710
56Legionellosis_Homo sapiens_hsa051340.71176530
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.70726583
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69984798
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69095122
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67144655
61Cardiac muscle contraction_Homo sapiens_hsa042600.62513306
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.61130632
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.60889320
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60175188
65Thyroid cancer_Homo sapiens_hsa052160.59578756
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57572567
67Apoptosis_Homo sapiens_hsa042100.57319682
68Small cell lung cancer_Homo sapiens_hsa052220.57084610
69Hematopoietic cell lineage_Homo sapiens_hsa046400.56130247
70Hepatitis B_Homo sapiens_hsa051610.55779450
71Shigellosis_Homo sapiens_hsa051310.55272921
72Allograft rejection_Homo sapiens_hsa053300.53725532
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53662507
74Huntingtons disease_Homo sapiens_hsa050160.53578783
75Leishmaniasis_Homo sapiens_hsa051400.51875863
76Influenza A_Homo sapiens_hsa051640.50471905
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47546482
78Basal cell carcinoma_Homo sapiens_hsa052170.46538052
79N-Glycan biosynthesis_Homo sapiens_hsa005100.42897826
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41094268
81MicroRNAs in cancer_Homo sapiens_hsa052060.40537426
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38009202
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36925941
84Colorectal cancer_Homo sapiens_hsa052100.36854105
85Vitamin digestion and absorption_Homo sapiens_hsa049770.36602602
86Asthma_Homo sapiens_hsa053100.36400073
87Parkinsons disease_Homo sapiens_hsa050120.36050964
88Glutathione metabolism_Homo sapiens_hsa004800.35997790
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35553632
90Biosynthesis of amino acids_Homo sapiens_hsa012300.34974257
91Wnt signaling pathway_Homo sapiens_hsa043100.34404195
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.32723637
93B cell receptor signaling pathway_Homo sapiens_hsa046620.31656269
94Hippo signaling pathway_Homo sapiens_hsa043900.31619422
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30898410
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30479180
97Selenocompound metabolism_Homo sapiens_hsa004500.30473912
98Arginine and proline metabolism_Homo sapiens_hsa003300.29938584
99Graft-versus-host disease_Homo sapiens_hsa053320.29744895
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29716502
101Hedgehog signaling pathway_Homo sapiens_hsa043400.28526324
102Sulfur metabolism_Homo sapiens_hsa009200.26975248
103Regulation of autophagy_Homo sapiens_hsa041400.26058430
104Lysine degradation_Homo sapiens_hsa003100.25923276
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25529226
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25077680
107Fatty acid metabolism_Homo sapiens_hsa012120.25067157
108Acute myeloid leukemia_Homo sapiens_hsa052210.24977718
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.24251237
110Chronic myeloid leukemia_Homo sapiens_hsa052200.23949683
111Alcoholism_Homo sapiens_hsa050340.23095519
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22085280
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22024300
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21502355
115Viral myocarditis_Homo sapiens_hsa054160.20880042
116T cell receptor signaling pathway_Homo sapiens_hsa046600.19610876
117Other glycan degradation_Homo sapiens_hsa005110.19567571
118Phototransduction_Homo sapiens_hsa047440.19406203
119Peroxisome_Homo sapiens_hsa041460.19294677
120Arachidonic acid metabolism_Homo sapiens_hsa005900.18620610
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18318931
122Autoimmune thyroid disease_Homo sapiens_hsa053200.18278622
123TGF-beta signaling pathway_Homo sapiens_hsa043500.18151268
124Pancreatic cancer_Homo sapiens_hsa052120.16319712
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16265511
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16138041
127Metabolic pathways_Homo sapiens_hsa011000.15879480
128Toxoplasmosis_Homo sapiens_hsa051450.14302552
129Pathways in cancer_Homo sapiens_hsa052000.14181682
130Pertussis_Homo sapiens_hsa051330.13515471
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.13392427
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13385696
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13284717
134Notch signaling pathway_Homo sapiens_hsa043300.13149365
135HIF-1 signaling pathway_Homo sapiens_hsa040660.11378461
136Fructose and mannose metabolism_Homo sapiens_hsa000510.10993913
137Fatty acid degradation_Homo sapiens_hsa000710.09866696
138Nitrogen metabolism_Homo sapiens_hsa009100.09252350
139Butanoate metabolism_Homo sapiens_hsa006500.08996520
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08019779
141Galactose metabolism_Homo sapiens_hsa000520.06631858
142Caffeine metabolism_Homo sapiens_hsa002320.06624906
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06500910
144Retinol metabolism_Homo sapiens_hsa008300.04608573
145Olfactory transduction_Homo sapiens_hsa047400.04133946

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