MIS18BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)5.98684714
2mitotic metaphase plate congression (GO:0007080)5.66986970
3protein localization to kinetochore (GO:0034501)5.60020788
4attachment of spindle microtubules to kinetochore (GO:0008608)5.27751075
5mitotic chromosome condensation (GO:0007076)5.24235613
6meiotic chromosome segregation (GO:0045132)5.21757751
7metaphase plate congression (GO:0051310)5.19048175
8kinetochore assembly (GO:0051382)5.17107973
9mitotic sister chromatid segregation (GO:0000070)5.04367963
10sister chromatid segregation (GO:0000819)4.92821475
11protein localization to chromosome, centromeric region (GO:0071459)4.91344912
12establishment of chromosome localization (GO:0051303)4.74538660
13* chromatin remodeling at centromere (GO:0031055)4.73838103
14* CENP-A containing nucleosome assembly (GO:0034080)4.72391283
15regulation of spindle organization (GO:0090224)4.69986504
16nuclear pore organization (GO:0006999)4.69130930
17nuclear pore complex assembly (GO:0051292)4.61803517
18DNA unwinding involved in DNA replication (GO:0006268)4.54293602
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.47841355
20* DNA replication-independent nucleosome assembly (GO:0006336)4.36234812
21* DNA replication-independent nucleosome organization (GO:0034724)4.36234812
22DNA strand elongation involved in DNA replication (GO:0006271)4.33587373
23telomere maintenance via semi-conservative replication (GO:0032201)4.27766080
24mitotic recombination (GO:0006312)4.25962334
25DNA replication initiation (GO:0006270)4.23803053
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.22813783
27mitotic nuclear envelope disassembly (GO:0007077)4.21357174
28regulation of mitotic spindle organization (GO:0060236)4.20744942
29DNA replication checkpoint (GO:0000076)4.19882690
30DNA strand elongation (GO:0022616)4.13668288
31DNA replication-dependent nucleosome organization (GO:0034723)4.11721904
32DNA replication-dependent nucleosome assembly (GO:0006335)4.11721904
33spindle checkpoint (GO:0031577)4.09396300
34telomere maintenance via recombination (GO:0000722)4.05354454
35mitotic G2/M transition checkpoint (GO:0044818)4.05275982
36mitotic sister chromatid cohesion (GO:0007064)4.02698788
37* histone exchange (GO:0043486)4.01469715
38chromosome segregation (GO:0007059)3.98967976
39nuclear envelope disassembly (GO:0051081)3.90654862
40membrane disassembly (GO:0030397)3.90654862
41regulation of chromosome segregation (GO:0051983)3.87729687
42spindle assembly checkpoint (GO:0071173)3.87452140
43DNA topological change (GO:0006265)3.86686812
44regulation of mitotic metaphase/anaphase transition (GO:0030071)3.83769994
45negative regulation of chromosome segregation (GO:0051985)3.83580903
46negative regulation of mitotic sister chromatid separation (GO:2000816)3.82283879
47negative regulation of mitotic sister chromatid segregation (GO:0033048)3.82283879
48negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.82283879
49negative regulation of sister chromatid segregation (GO:0033046)3.82283879
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.81920926
51regulation of mitotic spindle checkpoint (GO:1903504)3.81920926
52protein localization to chromosome (GO:0034502)3.80530493
53microtubule depolymerization (GO:0007019)3.79833439
54mitotic G2 DNA damage checkpoint (GO:0007095)3.78474559
55positive regulation of chromosome segregation (GO:0051984)3.77906245
56regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.75840886
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.73231084
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.73231084
59positive regulation of mitotic sister chromatid separation (GO:1901970)3.73231084
60mitotic spindle assembly checkpoint (GO:0007094)3.72314115
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.72066389
62mitotic spindle checkpoint (GO:0071174)3.69614362
63regulation of mitotic sister chromatid segregation (GO:0033047)3.67547320
64regulation of sister chromatid segregation (GO:0033045)3.67547320
65regulation of mitotic sister chromatid separation (GO:0010965)3.67547320
66telomere maintenance via telomere lengthening (GO:0010833)3.65259029
67pore complex assembly (GO:0046931)3.63770260
68regulation of centrosome cycle (GO:0046605)3.61035100
69protein K6-linked ubiquitination (GO:0085020)3.59580454
70centriole replication (GO:0007099)3.57140664
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.50922959
72chromosome condensation (GO:0030261)3.50398411
73non-recombinational repair (GO:0000726)3.49658331
74double-strand break repair via nonhomologous end joining (GO:0006303)3.49658331
75DNA double-strand break processing (GO:0000729)3.48960551
76nucleotide-excision repair, DNA gap filling (GO:0006297)3.48189185
77resolution of meiotic recombination intermediates (GO:0000712)3.44925514
78* chromatin assembly or disassembly (GO:0006333)3.44410087
79regulation of sister chromatid cohesion (GO:0007063)3.44379304
80regulation of centriole replication (GO:0046599)3.43531215
81DNA geometric change (GO:0032392)3.38976070
82DNA duplex unwinding (GO:0032508)3.36961672
83regulation of double-strand break repair via homologous recombination (GO:0010569)3.35461940
84regulation of DNA endoreduplication (GO:0032875)3.33688401
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.32433633
86establishment of integrated proviral latency (GO:0075713)3.31881396
87DNA packaging (GO:0006323)3.30041176
88V(D)J recombination (GO:0033151)3.29945363
89DNA ligation (GO:0006266)3.27911289
90negative regulation of DNA-dependent DNA replication (GO:2000104)3.27720426
91DNA conformation change (GO:0071103)3.24077739
92regulation of nuclear cell cycle DNA replication (GO:0033262)3.23427003
93DNA synthesis involved in DNA repair (GO:0000731)3.22429252
94nucleobase biosynthetic process (GO:0046112)3.21903884
95* ATP-dependent chromatin remodeling (GO:0043044)3.21153460
96telomere maintenance (GO:0000723)3.17681034
97IMP biosynthetic process (GO:0006188)3.17654295
98telomere organization (GO:0032200)3.15397718
99somatic cell DNA recombination (GO:0016444)3.13909410
100somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.13909410
101mitotic cell cycle (GO:0000278)3.10660001
102mismatch repair (GO:0006298)3.07038192
103replication fork processing (GO:0031297)3.06585043
104purine nucleobase biosynthetic process (GO:0009113)3.05947058
105regulation of histone H3-K9 methylation (GO:0051570)3.05382123
106chromosome organization (GO:0051276)3.03554832
107regulation of telomere maintenance via telomerase (GO:0032210)3.03277926
108regulation of helicase activity (GO:0051095)3.02853077
109negative regulation of mitosis (GO:0045839)3.02621292
110somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01288692
111somatic hypermutation of immunoglobulin genes (GO:0016446)3.01288692
112histone-serine phosphorylation (GO:0035404)2.99869418
113recombinational repair (GO:0000725)2.99573781
114nuclear envelope organization (GO:0006998)2.97723341
115negative regulation of DNA recombination (GO:0045910)2.97515956
116somatic diversification of immune receptors (GO:0002200)2.96970034
117double-strand break repair via homologous recombination (GO:0000724)2.96800983

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human6.95385915
2E2F4_17652178_ChIP-ChIP_JURKAT_Human5.08489098
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.39624714
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.67283067
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90573035
6AR_21909140_ChIP-Seq_LNCAP_Human2.72467418
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70638715
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57469215
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56767507
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.56263628
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.52331428
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.50357350
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.48103508
14MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.36185538
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30946163
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.27661251
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24441948
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18007982
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15932365
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13343467
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13256090
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.07674485
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05558479
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.02323607
25E2F7_22180533_ChIP-Seq_HELA_Human10.6725964
26XRN2_22483619_ChIP-Seq_HELA_Human1.97974444
27VDR_23849224_ChIP-Seq_CD4+_Human1.95772263
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94089239
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85323545
30FOXP3_21729870_ChIP-Seq_TREG_Human1.78167232
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73783647
32ELK1_19687146_ChIP-ChIP_HELA_Human1.70681054
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70203979
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67100700
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.66557932
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66080913
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66052115
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64388092
39DCP1A_22483619_ChIP-Seq_HELA_Human1.64333317
40TTF2_22483619_ChIP-Seq_HELA_Human1.61937280
41EWS_26573619_Chip-Seq_HEK293_Human1.61075503
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58571260
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.51268144
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50508008
45CIITA_25753668_ChIP-Seq_RAJI_Human1.50089341
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48452992
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47486329
48* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45500596
49GABP_19822575_ChIP-Seq_HepG2_Human1.42825616
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42781072
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40953925
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40360907
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39544479
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35933960
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34775375
56KDM5A_27292631_Chip-Seq_BREAST_Human1.34652160
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30279638
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29518298
59MYB_26560356_Chip-Seq_TH2_Human1.28144172
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25670889
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24545770
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23834956
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23647574
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23595082
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21681477
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20408629
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19302197
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18968870
69GATA1_22025678_ChIP-Seq_K562_Human1.17885614
70FUS_26573619_Chip-Seq_HEK293_Human1.17837262
71MYC_22102868_ChIP-Seq_BL_Human1.13374144
72SCL_19346495_ChIP-Seq_HPC-7_Human1.12086364
73IRF8_22096565_ChIP-ChIP_GC-B_Human1.08382793
74IRF1_19129219_ChIP-ChIP_H3396_Human1.06674946
75MYC_18940864_ChIP-ChIP_HL60_Human1.05854091
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05040748
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.05034510
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04920225
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04336741
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04220489
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03293070
82MYB_26560356_Chip-Seq_TH1_Human1.00418188
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00307620
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97011630
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95743941
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94818663
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94654755
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94609376
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.93590232
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93379897
91VDR_22108803_ChIP-Seq_LS180_Human0.92610332
92TFEB_21752829_ChIP-Seq_HELA_Human0.92499542
93SRF_21415370_ChIP-Seq_HL-1_Mouse0.91939426
94ZNF274_21170338_ChIP-Seq_K562_Hela0.91920726
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90667343
96FLI1_27457419_Chip-Seq_LIVER_Mouse0.88147815
97IGF1R_20145208_ChIP-Seq_DFB_Human0.87585109
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.86762779
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83523128
100IRF8_21731497_ChIP-ChIP_J774_Mouse0.82701830
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81991076
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81959980
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81959980
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81959980
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81364023
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80775559
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.79973022
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79378408
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79170614
110* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78307205
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78000796
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77928255
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.77493169
114STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.76384436
115* SPI1_23547873_ChIP-Seq_NB4_Human0.73252090
116NANOG_16153702_ChIP-ChIP_HESCs_Human0.72772366
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71104013
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.68531429
119TCF3_18692474_ChIP-Seq_MEFs_Mouse0.68470892
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.68201952
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.66388255
122SOX17_20123909_ChIP-Seq_XEN_Mouse0.65809332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.49787929
2MP0010094_abnormal_chromosome_stability5.27033960
3MP0003111_abnormal_nucleus_morphology4.88087626
4MP0003077_abnormal_cell_cycle4.29372828
5MP0008057_abnormal_DNA_replication4.27504627
6MP0004957_abnormal_blastocyst_morpholog4.13168769
7MP0008058_abnormal_DNA_repair3.54877347
8MP0008007_abnormal_cellular_replicative2.98654741
9MP0008877_abnormal_DNA_methylation2.84201331
10MP0008932_abnormal_embryonic_tissue2.58653466
11MP0003123_paternal_imprinting2.57157740
12MP0002009_preneoplasia2.46271590
13MP0002396_abnormal_hematopoietic_system2.24009764
14MP0010307_abnormal_tumor_latency2.23881639
15MP0000350_abnormal_cell_proliferation2.23202106
16MP0001730_embryonic_growth_arrest2.14865564
17MP0003786_premature_aging2.10875362
18MP0005075_abnormal_melanosome_morpholog2.10619695
19MP0003121_genomic_imprinting1.91242392
20MP0002166_altered_tumor_susceptibility1.88050841
21MP0001835_abnormal_antigen_presentation1.87196781
22MP0005380_embryogenesis_phenotype1.78452810
23MP0001672_abnormal_embryogenesis/_devel1.78452810
24MP0001697_abnormal_embryo_size1.69130703
25MP0003890_abnormal_embryonic-extraembry1.61651302
26MP0010352_gastrointestinal_tract_polyps1.60514375
27MP0002006_tumorigenesis1.57761548
28MP0002085_abnormal_embryonic_tissue1.56425346
29MP0003984_embryonic_growth_retardation1.55581265
30MP0002210_abnormal_sex_determination1.55352107
31MP0000490_abnormal_crypts_of1.51653674
32MP0002088_abnormal_embryonic_growth/wei1.51005574
33MP0006292_abnormal_olfactory_placode1.50600362
34MP0003718_maternal_effect1.48802602
35MP0000313_abnormal_cell_death1.43443601
36MP0002080_prenatal_lethality1.41551937
37MP0002084_abnormal_developmental_patter1.41278871
38MP0002086_abnormal_extraembryonic_tissu1.39027533
39MP0003567_abnormal_fetal_cardiomyocyte1.39024210
40MP0004197_abnormal_fetal_growth/weight/1.38709118
41MP0005076_abnormal_cell_differentiation1.35130926
42MP0004808_abnormal_hematopoietic_stem1.34771087
43MP0002019_abnormal_tumor_incidence1.33824901
44MP0001145_abnormal_male_reproductive1.29823083
45MP0001293_anophthalmia1.26813877
46MP0003787_abnormal_imprinting1.26290557
47MP0001800_abnormal_humoral_immune1.23225576
48MP0001929_abnormal_gametogenesis1.23055199
49MP0003941_abnormal_skin_development1.21798481
50MP0010030_abnormal_orbit_morphology1.19812120
51MP0000653_abnormal_sex_gland1.16916746
52MP0005671_abnormal_response_to1.14352934
53MP0003315_abnormal_perineum_morphology1.13549329
54MP0006072_abnormal_retinal_apoptosis1.11727342
55MP0000566_synostosis1.07238079
56MP0009053_abnormal_anal_canal1.06270661
57MP0003937_abnormal_limbs/digits/tail_de1.04929167
58MP0001119_abnormal_female_reproductive1.04906478
59MP0000569_abnormal_digit_pigmentation1.04898669
60MP0000716_abnormal_immune_system1.03469732
61MP0000703_abnormal_thymus_morphology1.00257669
62MP0002420_abnormal_adaptive_immunity0.99991761
63MP0001819_abnormal_immune_cell0.99199043
64MP0002452_abnormal_antigen_presenting0.94828025
65MP0009672_abnormal_birth_weight0.93987402
66MP0004147_increased_porphyrin_level0.91489391
67MP0008995_early_reproductive_senescence0.89584515
68MP0003763_abnormal_thymus_physiology0.89043539
69MP0002398_abnormal_bone_marrow0.87175455
70MP0009703_decreased_birth_body0.86381478
71MP0001286_abnormal_eye_development0.85731726
72MP0001545_abnormal_hematopoietic_system0.84870949
73MP0005397_hematopoietic_system_phenotyp0.84870949
74MP0002723_abnormal_immune_serum0.83771330
75MP0006054_spinal_hemorrhage0.82583822
76MP0000372_irregular_coat_pigmentation0.82046471
77MP0002111_abnormal_tail_morphology0.81329759
78MP0009697_abnormal_copulation0.81254585
79MP0002095_abnormal_skin_pigmentation0.81149381
80MP0002722_abnormal_immune_system0.78828846
81MP0000685_abnormal_immune_system0.77486929
82MP0000383_abnormal_hair_follicle0.77308778
83MP0003806_abnormal_nucleotide_metabolis0.76985946
84MP0001853_heart_inflammation0.75798446
85MP0006035_abnormal_mitochondrial_morpho0.75694602
86MP0001915_intracranial_hemorrhage0.75418684
87MP0000689_abnormal_spleen_morphology0.74510970
88MP0005464_abnormal_platelet_physiology0.73455250
89MP0002405_respiratory_system_inflammati0.72414956
90MP0000537_abnormal_urethra_morphology0.71373018
91MP0005000_abnormal_immune_tolerance0.71033594
92MP0005384_cellular_phenotype0.70797497
93MP0002160_abnormal_reproductive_system0.70655630
94MP0002938_white_spotting0.69765138
95MP0005389_reproductive_system_phenotype0.69656983
96MP0003119_abnormal_digestive_system0.69475671
97MP0000432_abnormal_head_morphology0.68961895
98MP0005621_abnormal_cell_physiology0.68474300
99MP0002102_abnormal_ear_morphology0.68151529
100MP0004264_abnormal_extraembryonic_tissu0.66513776
101MP0003698_abnormal_male_reproductive0.65841351
102MP0009333_abnormal_splenocyte_physiolog0.65060411
103MP0002075_abnormal_coat/hair_pigmentati0.64885533
104MP0005395_other_phenotype0.64424979
105MP0002092_abnormal_eye_morphology0.63839665
106MP0006036_abnormal_mitochondrial_physio0.63624080
107MP0002419_abnormal_innate_immunity0.63523192
108MP0003755_abnormal_palate_morphology0.62864295
109MP0000516_abnormal_urinary_system0.62309121
110MP0005367_renal/urinary_system_phenotyp0.62309121
111MP0000858_altered_metastatic_potential0.62056317
112MP0002429_abnormal_blood_cell0.61818356
113MP0000015_abnormal_ear_pigmentation0.61163109
114MP0001186_pigmentation_phenotype0.60828964
115MP0005408_hypopigmentation0.59694822
116MP0003699_abnormal_female_reproductive0.59661174
117MP0005174_abnormal_tail_pigmentation0.59487407
118MP0000465_gastrointestinal_hemorrhage0.59197895
119MP0003935_abnormal_craniofacial_develop0.59163224
120MP0004133_heterotaxia0.59154522
121MP0000427_abnormal_hair_cycle0.58876916
122MP0001919_abnormal_reproductive_system0.58546455
123MP0000358_abnormal_cell_content/0.57317257
124MP0003943_abnormal_hepatobiliary_system0.57007967
125MP0003115_abnormal_respiratory_system0.56663418
126MP0002697_abnormal_eye_size0.56302232
127MP0009278_abnormal_bone_marrow0.56109904
128MP0003136_yellow_coat_color0.53894468
129MP0002161_abnormal_fertility/fecundity0.53783655
130MP0000428_abnormal_craniofacial_morphol0.53779553

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.47007543
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.19193916
3Abnormality of chromosome stability (HP:0003220)4.08338420
4Birth length less than 3rd percentile (HP:0003561)4.02383903
5Meckel diverticulum (HP:0002245)3.72526240
6Panhypogammaglobulinemia (HP:0003139)3.68848013
7Abnormality of the preputium (HP:0100587)3.57911012
8B lymphocytopenia (HP:0010976)3.55657004
9Abnormality of the ileum (HP:0001549)3.55204234
10Patellar aplasia (HP:0006443)3.41894063
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.41479660
12Abnormality of B cell number (HP:0010975)3.40552249
13Reticulocytopenia (HP:0001896)3.34846414
14Duodenal stenosis (HP:0100867)3.30952059
15Small intestinal stenosis (HP:0012848)3.30952059
16Colon cancer (HP:0003003)3.29606709
17Impulsivity (HP:0100710)3.29225127
18Volvulus (HP:0002580)3.28835123
19Abnormal lung lobation (HP:0002101)3.25994722
20Combined immunodeficiency (HP:0005387)3.25701561
21Ectopic kidney (HP:0000086)3.20192766
22Medulloblastoma (HP:0002885)3.19742477
23Breast hypoplasia (HP:0003187)3.18703238
24Nephroblastoma (Wilms tumor) (HP:0002667)3.18599799
25Aplasia/Hypoplasia of the patella (HP:0006498)3.17902464
26Abnormality of the labia minora (HP:0012880)3.17440034
27Supernumerary spleens (HP:0009799)3.07765968
28Myelodysplasia (HP:0002863)3.06299643
29Absent radius (HP:0003974)3.01790476
30Selective tooth agenesis (HP:0001592)2.98675971
31Embryonal renal neoplasm (HP:0011794)2.98560592
32Increased nuchal translucency (HP:0010880)2.97789479
33Severe combined immunodeficiency (HP:0004430)2.94868059
34Absent forearm bone (HP:0003953)2.80565351
35Aplasia involving forearm bones (HP:0009822)2.80565351
36Sloping forehead (HP:0000340)2.79992874
37Oral leukoplakia (HP:0002745)2.77714463
38Facial hemangioma (HP:0000329)2.76710796
39Agammaglobulinemia (HP:0004432)2.75320362
40Abnormality of the duodenum (HP:0002246)2.72713221
41T lymphocytopenia (HP:0005403)2.71796848
42Duplicated collecting system (HP:0000081)2.71185418
43Carpal bone hypoplasia (HP:0001498)2.68738749
44Abnormality of the prostate (HP:0008775)2.68026156
45Ependymoma (HP:0002888)2.66967541
46Agnosia (HP:0010524)2.65940425
4711 pairs of ribs (HP:0000878)2.56672945
48Rhabdomyosarcoma (HP:0002859)2.56338932
49Absent thumb (HP:0009777)2.56273041
50Bone marrow hypocellularity (HP:0005528)2.51469833
51Abnormality of the carotid arteries (HP:0005344)2.49918173
52Abnormality of the renal collecting system (HP:0004742)2.49575699
53IgM deficiency (HP:0002850)2.44337282
54Abnormality of T cell number (HP:0011839)2.43165502
55Recurrent viral infections (HP:0004429)2.43115952
56Abnormal number of incisors (HP:0011064)2.39327673
57Thyroiditis (HP:0100646)2.38420376
58Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.35783277
59Short 4th metacarpal (HP:0010044)2.35783277
60Prostate neoplasm (HP:0100787)2.35250743
61Aplastic anemia (HP:0001915)2.33703890
62Clubbing of toes (HP:0100760)2.33091885
63Cafe-au-lait spot (HP:0000957)2.31276098
64Short thumb (HP:0009778)2.27416392
65Tracheoesophageal fistula (HP:0002575)2.24835780
66IgG deficiency (HP:0004315)2.23475883
67Triphalangeal thumb (HP:0001199)2.18505688
68Abnormality of DNA repair (HP:0003254)2.18434877
69Horseshoe kidney (HP:0000085)2.17655267
70Degeneration of anterior horn cells (HP:0002398)2.17146912
71Abnormality of the anterior horn cell (HP:0006802)2.17146912
72Premature graying of hair (HP:0002216)2.13534588
73Neoplasm of the pancreas (HP:0002894)2.13468602
74Proximal placement of thumb (HP:0009623)2.13062612
75Recurrent cutaneous fungal infections (HP:0011370)2.11384115
76Chronic mucocutaneous candidiasis (HP:0002728)2.11384115
77Embryonal neoplasm (HP:0002898)2.09761340
78Deviation of the thumb (HP:0009603)2.07857835
79Abnormality of T cells (HP:0002843)2.07162617
80Neoplasm of the colon (HP:0100273)2.06098576
81Abnormal spermatogenesis (HP:0008669)2.04309308
82Neoplasm of the oral cavity (HP:0100649)2.02987691
83High pitched voice (HP:0001620)2.02916124
84Deep philtrum (HP:0002002)2.02331754
85Pancreatic islet-cell hyperplasia (HP:0004510)2.02072294
86Atresia of the external auditory canal (HP:0000413)2.01803025
87Abnormality of chromosome segregation (HP:0002916)2.00892140
88Aplasia/Hypoplasia of the earlobes (HP:0009906)1.99790282
89Aplasia/Hypoplasia of the sternum (HP:0006714)1.96761063
90Abnormality of the fingertips (HP:0001211)1.96627162
91Prominent nose (HP:0000448)1.96492363
92Abnormality of male internal genitalia (HP:0000022)1.94664210
93Cleft eyelid (HP:0000625)1.94237718
94Missing ribs (HP:0000921)1.92061181
95Abnormal delayed hypersensitivity skin test (HP:0002963)1.92016322
96Rough bone trabeculation (HP:0100670)1.88684212
97Capillary hemangiomas (HP:0005306)1.88636704
98Short middle phalanx of the 5th finger (HP:0004220)1.87964889
99Glioma (HP:0009733)1.87119960
100Squamous cell carcinoma (HP:0002860)1.86785477
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86700651
102Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86617361
103Microvesicular hepatic steatosis (HP:0001414)1.82853560
104Oligodactyly (HP:0012165)1.82612139
105Thrombocytosis (HP:0001894)1.82385695
106Acute myeloid leukemia (HP:0004808)1.81779519
107Neoplasm of striated muscle (HP:0009728)1.81514883
108Sandal gap (HP:0001852)1.81317354
109Cortical dysplasia (HP:0002539)1.79452875
110Cellular immunodeficiency (HP:0005374)1.79407183
111Abnormality of the astrocytes (HP:0100707)1.79348700
112Astrocytoma (HP:0009592)1.79348700
113Dyschromatopsia (HP:0007641)1.78798057
114Hypoplasia of the thymus (HP:0000778)1.77707118
115Abnormality of the pons (HP:0007361)1.77236278
116Ovarian neoplasm (HP:0100615)1.75399400
117Pancytopenia (HP:0001876)1.75206670
118Lymphoma (HP:0002665)1.75046417
119Basal cell carcinoma (HP:0002671)1.74944913
120Abnormality of cells of the erythroid lineage (HP:0012130)1.74901671
121Pallor (HP:0000980)1.74892687
122Recurrent fungal infections (HP:0002841)1.74194532
123Gastrointestinal carcinoma (HP:0002672)1.74189197
124Malignant gastrointestinal tract tumors (HP:0006749)1.74189197
125Biliary tract neoplasm (HP:0100574)1.73743447
126Amaurosis fugax (HP:0100576)1.72736787
127Abnormality of T cell physiology (HP:0011840)1.72600900
128Eosinophilia (HP:0001880)1.72520125
129Long eyelashes (HP:0000527)1.71208481
130Abnormal number of erythroid precursors (HP:0012131)1.71058399
131Granulocytopenia (HP:0001913)1.70566248
132Abnormality of abdominal situs (HP:0011620)1.69538885
133Abdominal situs inversus (HP:0003363)1.69538885
134Arteriovenous malformation (HP:0100026)1.69420010
135Neoplasm of the adrenal cortex (HP:0100641)1.68468276
136Abnormality of eosinophils (HP:0001879)1.67957789
137Premature ovarian failure (HP:0008209)1.67596933
138Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67033351
139Hypoplasia of the pons (HP:0012110)1.66383425
140Acute lymphatic leukemia (HP:0006721)1.65300367
141Autoimmune hemolytic anemia (HP:0001890)1.63246899
142Type I transferrin isoform profile (HP:0003642)1.60224938
143Aplasia/Hypoplasia of the thymus (HP:0010515)1.59749910
144Rectovaginal fistula (HP:0000143)1.56187545
145Rectal fistula (HP:0100590)1.56187545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.93267516
2BUB14.67946733
3WEE14.17296709
4NEK23.64871901
5TTK3.22876175
6SRPK12.86885687
7PLK42.85612056
8BRSK22.78806245
9CDK122.50543129
10NEK12.49997220
11PLK12.48534980
12ACVR1B2.27634930
13EIF2AK12.25958968
14AURKB2.13265151
15MKNK12.08256572
16PLK32.01362543
17CCNB12.00172628
18ATR1.96550294
19STK41.79996306
20CHEK21.79371101
21BRSK11.79235813
22TLK11.75088660
23VRK11.70412496
24MKNK21.69950519
25VRK21.65704736
26MST41.64873452
27CDK71.61600531
28TAF11.61484144
29ZAK1.55624703
30PASK1.48568193
31TSSK61.41667621
32CHEK11.40961415
33BRD41.32919711
34CDK41.30604077
35AURKA1.30246593
36RPS6KA41.29604079
37STK101.27877832
38MAP3K81.26332600
39RPS6KB21.23267457
40ATM1.21853650
41EIF2AK31.19327713
42MELK1.18353576
43DYRK31.15458722
44BMPR1B1.14540133
45NLK1.09584425
46EIF2AK21.05130934
47KIT0.99515080
48CLK10.98807605
49CDK20.95982866
50STK30.95600018
51PBK0.95394648
52FRK0.93888135
53BMPR20.90786226
54TAOK30.90347716
55TGFBR10.90184949
56CDK190.89762958
57CDK60.87126891
58CDK10.87042918
59LATS10.83901483
60STK160.81839631
61TESK20.80100551
62PIM10.78343136
63BRAF0.75857139
64CDK80.74648969
65MAP4K20.70159944
66STK38L0.67706374
67WNK30.66733790
68MAP3K140.66036486
69TXK0.65501527
70EPHA20.65002187
71MAP3K100.64118264
72EEF2K0.62763287
73RPS6KA50.60179751
74PAK40.59861453
75CSNK2A10.59666542
76NUAK10.58965083
77MARK30.54974880
78CSNK2A20.54799474
79FLT30.49901437
80NME20.48513806
81SYK0.47981162
82ITK0.46201969
83GRK60.46173554
84TEC0.45296905
85IKBKE0.45033844
86RIPK40.45017593
87TRIM280.44987098
88SCYL20.44357758
89IRAK40.42904847
90YES10.42404541
91PAK10.41920950
92PRKDC0.41065008
93CDK90.40288519
94PRKCI0.39661188
95MAPK140.37259643
96KDR0.36752441
97LYN0.36465348
98PIK3CG0.34465111
99NEK90.34304660
100MAP2K20.32915407
101ERBB30.32301403
102ALK0.32230017
103AKT10.30499231
104FES0.29656523
105AKT30.28418456
106CHUK0.28311923
107MAP3K60.26052059
108TNIK0.24991787
109MAP4K10.24691991
110MAPK10.24476329
111GSK3B0.24466519
112CSNK1D0.24387833
113MTOR0.22968178
114MAP2K30.22922244
115PNCK0.22906407
116BTK0.22359491
117CSNK1E0.21640966
118AKT20.20305433
119RPS6KB10.18647778
120PLK20.14144738
121CDK30.13398798
122LATS20.12618220
123CSF1R0.10801457
124RPS6KL10.09707884
125RPS6KC10.09707884
126MAPK80.09031878

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.00123429
2Mismatch repair_Homo sapiens_hsa034304.56271784
3Homologous recombination_Homo sapiens_hsa034403.76836502
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55234983
5Cell cycle_Homo sapiens_hsa041103.44384730
6Base excision repair_Homo sapiens_hsa034103.39875929
7Spliceosome_Homo sapiens_hsa030403.24681046
8Fanconi anemia pathway_Homo sapiens_hsa034603.15870030
9RNA transport_Homo sapiens_hsa030133.12758364
10Nucleotide excision repair_Homo sapiens_hsa034203.02947690
11One carbon pool by folate_Homo sapiens_hsa006702.64373433
12RNA polymerase_Homo sapiens_hsa030202.63039900
13Non-homologous end-joining_Homo sapiens_hsa034502.49969716
14Basal transcription factors_Homo sapiens_hsa030222.25990570
15Ribosome_Homo sapiens_hsa030102.20641344
16mRNA surveillance pathway_Homo sapiens_hsa030152.13576201
17RNA degradation_Homo sapiens_hsa030182.13550050
18Pyrimidine metabolism_Homo sapiens_hsa002402.12147781
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10772490
20Proteasome_Homo sapiens_hsa030501.94696388
21p53 signaling pathway_Homo sapiens_hsa041151.94163903
22Systemic lupus erythematosus_Homo sapiens_hsa053221.88165171
23Oocyte meiosis_Homo sapiens_hsa041141.40890717
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29663476
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23262994
26Herpes simplex infection_Homo sapiens_hsa051681.15824129
27Viral carcinogenesis_Homo sapiens_hsa052031.15632804
28Epstein-Barr virus infection_Homo sapiens_hsa051691.14318425
29Purine metabolism_Homo sapiens_hsa002301.12608220
30MicroRNAs in cancer_Homo sapiens_hsa052060.98468022
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96069414
32Autoimmune thyroid disease_Homo sapiens_hsa053200.90639879
33HTLV-I infection_Homo sapiens_hsa051660.89494480
34Antigen processing and presentation_Homo sapiens_hsa046120.80481023
35Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79443625
36Alcoholism_Homo sapiens_hsa050340.76408533
37Small cell lung cancer_Homo sapiens_hsa052220.73011009
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70189457
39Type I diabetes mellitus_Homo sapiens_hsa049400.67139318
40TGF-beta signaling pathway_Homo sapiens_hsa043500.63921709
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60703993
42Selenocompound metabolism_Homo sapiens_hsa004500.59371081
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58868508
44Vitamin B6 metabolism_Homo sapiens_hsa007500.57324568
45Thyroid cancer_Homo sapiens_hsa052160.56707232
46Parkinsons disease_Homo sapiens_hsa050120.56580148
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55445441
48Propanoate metabolism_Homo sapiens_hsa006400.55256003
49Primary immunodeficiency_Homo sapiens_hsa053400.54246725
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.51925984
51B cell receptor signaling pathway_Homo sapiens_hsa046620.51647335
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50737738
53Colorectal cancer_Homo sapiens_hsa052100.50549904
54Oxidative phosphorylation_Homo sapiens_hsa001900.49878972
55Legionellosis_Homo sapiens_hsa051340.48552955
56Hippo signaling pathway_Homo sapiens_hsa043900.47977338
57Basal cell carcinoma_Homo sapiens_hsa052170.47307240
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46373066
59Lysine degradation_Homo sapiens_hsa003100.45297763
60Hepatitis B_Homo sapiens_hsa051610.44668974
61Notch signaling pathway_Homo sapiens_hsa043300.44187897
62Apoptosis_Homo sapiens_hsa042100.43662950
63Measles_Homo sapiens_hsa051620.42465781
64Influenza A_Homo sapiens_hsa051640.42450138
65Pentose phosphate pathway_Homo sapiens_hsa000300.39726460
66Adherens junction_Homo sapiens_hsa045200.39294447
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.38841775
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.35370658
69Chronic myeloid leukemia_Homo sapiens_hsa052200.35270738
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34839623
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.34547454
72Pathways in cancer_Homo sapiens_hsa052000.32945255
73Hematopoietic cell lineage_Homo sapiens_hsa046400.32909949
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32257587
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32093412
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31925260
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.31617690
78Prostate cancer_Homo sapiens_hsa052150.29570637
79FoxO signaling pathway_Homo sapiens_hsa040680.29182627
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29067607
81Shigellosis_Homo sapiens_hsa051310.28907394
82Fatty acid elongation_Homo sapiens_hsa000620.28315973
83Viral myocarditis_Homo sapiens_hsa054160.27612752
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26478898
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26442830
86Glutathione metabolism_Homo sapiens_hsa004800.26243781
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26062209
88Pancreatic cancer_Homo sapiens_hsa052120.25986139
89Biosynthesis of amino acids_Homo sapiens_hsa012300.24483353
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23852458
91Protein export_Homo sapiens_hsa030600.22190544
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21227836
93Folate biosynthesis_Homo sapiens_hsa007900.20846497
94Platelet activation_Homo sapiens_hsa046110.20280207
95N-Glycan biosynthesis_Homo sapiens_hsa005100.19814516
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19359459
97Bladder cancer_Homo sapiens_hsa052190.18431245
98Leishmaniasis_Homo sapiens_hsa051400.17313566
99Nitrogen metabolism_Homo sapiens_hsa009100.17231056
100Hedgehog signaling pathway_Homo sapiens_hsa043400.15676955
101HIF-1 signaling pathway_Homo sapiens_hsa040660.15432322
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15392085
103Wnt signaling pathway_Homo sapiens_hsa043100.15126451
104Melanoma_Homo sapiens_hsa052180.14749195
105Non-small cell lung cancer_Homo sapiens_hsa052230.14744283
106Renin-angiotensin system_Homo sapiens_hsa046140.14405953
107Metabolic pathways_Homo sapiens_hsa011000.14120069
108Asthma_Homo sapiens_hsa053100.14073565
109Peroxisome_Homo sapiens_hsa041460.13384180
110Staphylococcus aureus infection_Homo sapiens_hsa051500.12786491
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12636993
112Tuberculosis_Homo sapiens_hsa051520.11579454
113Huntingtons disease_Homo sapiens_hsa050160.11398934
114Allograft rejection_Homo sapiens_hsa053300.11165569
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10955701
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.10930560
117Graft-versus-host disease_Homo sapiens_hsa053320.10102456
118Acute myeloid leukemia_Homo sapiens_hsa052210.09782279
119Phototransduction_Homo sapiens_hsa047440.09616225
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.09384486
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09223820
122T cell receptor signaling pathway_Homo sapiens_hsa046600.09001524
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08957199
124mTOR signaling pathway_Homo sapiens_hsa041500.08784532
125Arachidonic acid metabolism_Homo sapiens_hsa005900.06992559
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.06483657

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