MISP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)7.48559894
2sulfate transmembrane transport (GO:1902358)6.87700606
3intestinal cholesterol absorption (GO:0030299)6.48264078
4regulation of autophagic vacuole assembly (GO:2000785)6.38356140
5purine ribonucleoside bisphosphate metabolic process (GO:0034035)6.36327434
63-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)6.36327434
7NADH metabolic process (GO:0006734)6.33315314
8negative regulation of macroautophagy (GO:0016242)6.22947827
9cytidine metabolic process (GO:0046087)5.89472664
10cytidine catabolic process (GO:0006216)5.89472664
11cytidine deamination (GO:0009972)5.89472664
12negative regulation of keratinocyte proliferation (GO:0010839)5.87244143
13bile acid and bile salt transport (GO:0015721)5.76658080
14bundle of His cell to Purkinje myocyte communication (GO:0086069)5.70696551
15sulfate transport (GO:0008272)5.68473632
16maintenance of gastrointestinal epithelium (GO:0030277)5.58777349
17angiotensin maturation (GO:0002003)5.57627811
18negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)5.48101813
19epoxygenase P450 pathway (GO:0019373)5.22484732
20protein neddylation (GO:0045116)5.13479173
21regulation of vacuole organization (GO:0044088)5.05687925
22regulation of vitamin metabolic process (GO:0030656)5.01870239
23positive regulation of guanylate cyclase activity (GO:0031284)4.96176335
24fat-soluble vitamin biosynthetic process (GO:0042362)4.80492409
25positive regulation of pseudopodium assembly (GO:0031274)4.79024102
26negative regulation of organelle assembly (GO:1902116)4.66815488
27regulation of cellular extravasation (GO:0002691)4.65011513
28actin filament depolymerization (GO:0030042)4.63486613
29regulation of systemic arterial blood pressure by hormone (GO:0001990)4.62824458
30regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.62824458
31endocrine process (GO:0050886)4.62824458
32UDP-N-acetylglucosamine metabolic process (GO:0006047)4.61596344
33intestinal epithelial cell development (GO:0060576)4.59887075
34sulfur compound transport (GO:0072348)4.57984602
35regulation of viral release from host cell (GO:1902186)4.53953732
36flavonoid metabolic process (GO:0009812)4.51355444
37negative regulation of T cell differentiation in thymus (GO:0033085)4.51325442
38fructose metabolic process (GO:0006000)4.47461208
39urea cycle (GO:0000050)4.47265925
40positive regulation of T cell differentiation in thymus (GO:0033089)4.38919983
41regulation of systemic arterial blood pressure (GO:0003073)4.32828944
42pyrimidine ribonucleoside catabolic process (GO:0046133)4.32479981
43calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.31312308
44epithelial structure maintenance (GO:0010669)4.30375130
45renal system process involved in regulation of blood volume (GO:0001977)4.29669076
46O-glycan processing (GO:0016266)4.28972602
47digestive system process (GO:0022600)4.28328745
48lipoprotein transport (GO:0042953)4.27896293
49regulation of pseudopodium assembly (GO:0031272)4.26251843
50vitamin A metabolic process (GO:0006776)4.25926497
51positive regulation of respiratory burst (GO:0060267)4.24855113
52alkaloid metabolic process (GO:0009820)4.24128759
53keratinocyte development (GO:0003334)4.23436503
54urea metabolic process (GO:0019627)4.20370139
55negative regulation of protein tyrosine kinase activity (GO:0061099)4.19644134
56chondrocyte proliferation (GO:0035988)4.13275801
57renal filtration (GO:0097205)4.11399016
58cellular glucuronidation (GO:0052695)4.09550969
59positive regulation of epidermal cell differentiation (GO:0045606)4.09261097
60cellular response to hepatocyte growth factor stimulus (GO:0035729)4.09045059
61response to hepatocyte growth factor (GO:0035728)4.09045059
62receptor guanylyl cyclase signaling pathway (GO:0007168)4.07351991
63glomerular filtration (GO:0003094)4.07169336
64positive regulation of Cdc42 GTPase activity (GO:0043089)4.05942043
65drug metabolic process (GO:0017144)4.02384363
66uronic acid metabolic process (GO:0006063)4.02000416
67glucuronate metabolic process (GO:0019585)4.02000416
68regulation of cGMP biosynthetic process (GO:0030826)4.01612598
69epithelial cell-cell adhesion (GO:0090136)4.01114473
70sulfur amino acid catabolic process (GO:0000098)3.99113765
71hemidesmosome assembly (GO:0031581)3.97466487
72vitamin transmembrane transport (GO:0035461)3.92311494
73diacylglycerol metabolic process (GO:0046339)3.87291180
74hepatocyte apoptotic process (GO:0097284)3.82937013
75regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.81666821
76nitrogen cycle metabolic process (GO:0071941)3.81099833
77regulation of bile acid biosynthetic process (GO:0070857)3.76250096
78desmosome organization (GO:0002934)3.70092353
79regulation of cholesterol homeostasis (GO:2000188)3.68097316
80drug catabolic process (GO:0042737)3.65302010
81adhesion of symbiont to host cell (GO:0044650)3.63380795
82virion attachment to host cell (GO:0019062)3.63380795
83GDP-mannose metabolic process (GO:0019673)3.59984285
84purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.59551140
85ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.59551140
86nucleoside bisphosphate biosynthetic process (GO:0033866)3.59551140
87auditory receptor cell differentiation (GO:0042491)3.53962655
88peptide hormone processing (GO:0016486)3.53723768
89positive regulation of epidermis development (GO:0045684)3.50983711
90regulation of keratinocyte proliferation (GO:0010837)3.50870968
91very-low-density lipoprotein particle assembly (GO:0034379)3.48547443
92glutamine family amino acid biosynthetic process (GO:0009084)3.37755338
93oligosaccharide biosynthetic process (GO:0009312)3.37643510
94sulfation (GO:0051923)3.36821839
95regulation of respiratory burst (GO:0060263)3.32308798
96glycosphingolipid catabolic process (GO:0046479)3.30645834
97regulation of water loss via skin (GO:0033561)3.30413379
98ethanol oxidation (GO:0006069)3.30374736
99glycolipid catabolic process (GO:0019377)3.29619530
100vitamin transport (GO:0051180)3.29261321
101regulation of cGMP metabolic process (GO:0030823)3.29195036
102homocysteine metabolic process (GO:0050667)3.28207647
103bicarbonate transport (GO:0015701)3.28199665
104positive regulation of glycoprotein biosynthetic process (GO:0010560)3.26599817
105positive regulation of glycoprotein metabolic process (GO:1903020)3.25539047
106modified amino acid transport (GO:0072337)3.22911223
107renal absorption (GO:0070293)3.22523281
108drug transmembrane transport (GO:0006855)3.17808873
109negative regulation of receptor activity (GO:2000272)3.17032676
110glucose 6-phosphate metabolic process (GO:0051156)3.16575836
111sphingomyelin metabolic process (GO:0006684)3.16405442
112positive regulation of fatty acid beta-oxidation (GO:0032000)3.16297012
113phosphatidylcholine biosynthetic process (GO:0006656)3.15898477
114digestion (GO:0007586)3.15834059
115arginine metabolic process (GO:0006525)3.08584199
116ribonucleoside bisphosphate metabolic process (GO:0033875)3.06968488
117nucleoside bisphosphate metabolic process (GO:0033865)3.06968488
118purine nucleoside bisphosphate metabolic process (GO:0034032)3.06968488
119renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.06727166
120fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.03685379
121multicellular organismal water homeostasis (GO:0050891)3.03608595
122antibacterial humoral response (GO:0019731)3.03518088
123transcytosis (GO:0045056)3.01892817
124antimicrobial humoral response (GO:0019730)3.01063630
125establishment of skin barrier (GO:0061436)2.98843946
126phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.98495829
127striated muscle atrophy (GO:0014891)2.97686670
128antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.96239897
129thrombin receptor signaling pathway (GO:0070493)2.95832943
130ethanol metabolic process (GO:0006067)2.95439491
131citrulline biosynthetic process (GO:0019240)2.94415878
132plasma lipoprotein particle assembly (GO:0034377)2.93931345
133nucleotide salvage (GO:0043173)2.93910138
134nucleoside diphosphate biosynthetic process (GO:0009133)2.93619960
135positive regulation of lipid catabolic process (GO:0050996)2.92523326
136drug transport (GO:0015893)2.92005847
137bone resorption (GO:0045453)2.91792378
138somite development (GO:0061053)2.91145819
139activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.91090878
140proline biosynthetic process (GO:0006561)2.89738259
141neurotransmitter biosynthetic process (GO:0042136)2.88810637
142cellular response to nitric oxide (GO:0071732)2.87660908
143cGMP-mediated signaling (GO:0019934)2.86906192
144thyroid hormone metabolic process (GO:0042403)2.86828125
145ventricular cardiac muscle cell action potential (GO:0086005)2.86813153
146primary alcohol catabolic process (GO:0034310)2.86687406
147regulation of cholesterol metabolic process (GO:0090181)2.85360737
148cyclooxygenase pathway (GO:0019371)2.84915852
149regulation of triglyceride catabolic process (GO:0010896)2.83464059
150branching involved in mammary gland duct morphogenesis (GO:0060444)2.83267749
151adhesion of symbiont to host (GO:0044406)2.82938373
152phospholipid homeostasis (GO:0055091)2.82805023
153regulation of guanylate cyclase activity (GO:0031282)2.81626792
154phospholipid scrambling (GO:0017121)2.81099851
155peptide catabolic process (GO:0043171)2.77106504
156lipoprotein metabolic process (GO:0042157)2.75650464
157cholesterol homeostasis (GO:0042632)2.74090760
158sterol homeostasis (GO:0055092)2.72218020
159phospholipid efflux (GO:0033700)2.71712127
160response to hydroperoxide (GO:0033194)2.71659464
161hormone catabolic process (GO:0042447)2.71017090
162membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.70529393
163sperm capacitation (GO:0048240)2.66163763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.94815051
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.63783605
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.47480749
4ZNF263_19887448_ChIP-Seq_K562_Human2.88752005
5SOX2_20726797_ChIP-Seq_SW620_Human2.78976374
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.77935722
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.72098603
8GATA4_25053715_ChIP-Seq_YYC3_Human2.65055614
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.56829817
10GATA6_25053715_ChIP-Seq_YYC3_Human2.46732592
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.44873531
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.41618431
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.39074057
14VDR_22108803_ChIP-Seq_LS180_Human2.37459518
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.32178477
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27394209
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.19625951
18PPAR_26484153_Chip-Seq_NCI-H1993_Human1.94774813
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.93410507
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.87871502
21KLF5_25053715_ChIP-Seq_YYC3_Human1.81059578
22SRY_22984422_ChIP-ChIP_TESTIS_Rat1.77805834
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.76944970
24RXR_22158963_ChIP-Seq_LIVER_Mouse1.73263764
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.72786634
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.72363676
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.70615317
28RACK7_27058665_Chip-Seq_MCF-7_Human1.70610246
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.70585053
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66589710
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.65314560
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.65119417
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62811025
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61449660
35KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60968431
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56286883
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55394580
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52874303
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52525290
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.52254385
41BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.50830228
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49440260
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.49315338
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.46056711
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.45566392
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45556206
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40477222
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.40186123
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37380280
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37233039
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.36027039
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34114099
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29404547
54CLOCK_20551151_ChIP-Seq_293T_Human1.28110534
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27710355
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27210479
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26942409
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26249096
59ATF3_27146783_Chip-Seq_COLON_Human1.25467762
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25227653
61FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24440834
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19962890
63SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18977549
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18977549
65AR_21909140_ChIP-Seq_LNCAP_Human1.18102303
66BCL6_27268052_Chip-Seq_Bcells_Human1.16055647
67EGR1_19032775_ChIP-ChIP_M12_Human1.15208759
68SA1_27219007_Chip-Seq_Bcells_Human1.14354404
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14281427
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13667679
71JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.13474020
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12860222
73GATA1_26923725_Chip-Seq_HPCs_Mouse1.12273489
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10583027
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.10361374
76AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10214169
77FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.10159602
78JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09985991
79GATA2_19941826_ChIP-Seq_K562_Human1.08173483
80FOXA1_25552417_ChIP-Seq_VCAP_Human1.07960479
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07792536
82SMC4_20622854_ChIP-Seq_HELA_Human1.05517122
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05045166
84RXR_22108803_ChIP-Seq_LS180_Human1.04615467
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03858078
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03636634
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02389412
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01875542
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01499627
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01145349
91HNF4A_19822575_ChIP-Seq_HepG2_Human1.01043707
92GATA3_24758297_ChIP-Seq_MCF-7_Human1.00818297
93VDR_21846776_ChIP-Seq_THP-1_Human1.00461636
94LXR_22292898_ChIP-Seq_THP-1_Human1.00087036
95ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99948167
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99769779
97TP63_22573176_ChIP-Seq_HFKS_Human0.99332672
98P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98493022
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97600956
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96546886
101FOXA2_19822575_ChIP-Seq_HepG2_Human0.96361060
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94726963
103SA1_27219007_Chip-Seq_ERYTHROID_Human0.94446453
104DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94192764
105CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93241277
106E2F1_20622854_ChIP-Seq_HELA_Human0.92609933
107OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91150640
108PHF8_20622854_ChIP-Seq_HELA_Human0.89943695
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88930453
110GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88043022
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87629329
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.87326359
113CREB1_26743006_Chip-Seq_LNCaP_Human0.85853489
114HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85521067
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84926962
116BCOR_27268052_Chip-Seq_Bcells_Human0.84295721
117DROSHA_22980978_ChIP-Seq_HELA_Human0.83981900
118TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83624873
119NANOG_20526341_ChIP-Seq_ESCs_Human0.83507253
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.83214949
121NANOG_18692474_ChIP-Seq_MEFs_Mouse0.79594823
122SMC1_22415368_ChIP-Seq_MEFs_Mouse0.77599742
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77531303
124GATA1_19941826_ChIP-Seq_K562_Human0.75970762
125P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75144863
126P68_20966046_ChIP-Seq_HELA_Human0.73754102
127CTCF_27219007_Chip-Seq_Bcells_Human0.72508126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle8.55242710
2MP0003283_abnormal_digestive_organ5.66996715
3MP0005360_urolithiasis5.26067166
4MP0001666_abnormal_nutrient_absorption4.62064143
5MP0000462_abnormal_digestive_system3.79891772
6MP0004264_abnormal_extraembryonic_tissu3.57438234
7MP0003866_abnormal_defecation3.13305751
8MP0003315_abnormal_perineum_morphology2.77364548
9MP0005085_abnormal_gallbladder_physiolo2.64624684
10MP0009053_abnormal_anal_canal2.60342308
11MP0002234_abnormal_pharynx_morphology2.51547809
12MP0005409_darkened_coat_color2.41738757
13MP0000537_abnormal_urethra_morphology2.36566278
14MP0005381_digestive/alimentary_phenotyp2.15857485
15MP0003252_abnormal_bile_duct2.15697490
16MP0008875_abnormal_xenobiotic_pharmacok2.11165986
17MP0010155_abnormal_intestine_physiology2.03959291
18MP0004019_abnormal_vitamin_homeostasis2.03343112
19MP0001663_abnormal_digestive_system2.02468026
20MP0000477_abnormal_intestine_morphology2.02118277
21MP0001873_stomach_inflammation2.01633169
22MP0002139_abnormal_hepatobiliary_system1.98006858
23MP0003878_abnormal_ear_physiology1.94242603
24MP0005377_hearing/vestibular/ear_phenot1.94242603
25MP0010678_abnormal_skin_adnexa1.90553003
26MP0002822_catalepsy1.86945395
27MP0004782_abnormal_surfactant_physiolog1.78637757
28MP0003705_abnormal_hypodermis_morpholog1.77678953
29MP0001664_abnormal_digestion1.74308614
30MP0000490_abnormal_crypts_of1.72403049
31MP0000566_synostosis1.70674301
32MP0002796_impaired_skin_barrier1.67490111
33MP0000538_abnormal_urinary_bladder1.65993658
34MP0004858_abnormal_nervous_system1.59885327
35MP0010352_gastrointestinal_tract_polyps1.55423306
36MP0005365_abnormal_bile_salt1.54940544
37MP0004043_abnormal_pH_regulation1.54014326
38MP0009840_abnormal_foam_cell1.53717865
39MP0003566_abnormal_cell_adhesion1.53543970
40MP0002098_abnormal_vibrissa_morphology1.53159980
41MP0010329_abnormal_lipoprotein_level1.46915218
42MP0001765_abnormal_ion_homeostasis1.40879950
43MP0009643_abnormal_urine_homeostasis1.39248772
44MP0003300_gastrointestinal_ulcer1.38996486
45MP0002254_reproductive_system_inflammat1.35604287
46MP0006054_spinal_hemorrhage1.33701128
47MP0005670_abnormal_white_adipose1.29963450
48MP0004947_skin_inflammation1.29812549
49MP0008004_abnormal_stomach_pH1.28935669
50MP0005167_abnormal_blood-brain_barrier1.28094633
51MP0005084_abnormal_gallbladder_morpholo1.28048191
52MP0001849_ear_inflammation1.21416332
53MP0003183_abnormal_peptide_metabolism1.20864760
54MP0003453_abnormal_keratinocyte_physiol1.17489111
55MP0000613_abnormal_salivary_gland1.10909822
56MP0005636_abnormal_mineral_homeostasis1.08132120
57MP0003045_fibrosis1.08003553
58MP0001188_hyperpigmentation1.05965109
59MP0000467_abnormal_esophagus_morphology1.04098486
60MP0005310_abnormal_salivary_gland1.03877380
61MP0001756_abnormal_urination1.02575465
62MP0001764_abnormal_homeostasis0.99254913
63MP0003806_abnormal_nucleotide_metabolis0.96104220
64MP0000762_abnormal_tongue_morphology0.93935301
65MP0003868_abnormal_feces_composition0.93419781
66MP0005451_abnormal_body_composition0.93111495
67MP0005501_abnormal_skin_physiology0.91770998
68MP0001216_abnormal_epidermal_layer0.90736502
69MP0000470_abnormal_stomach_morphology0.90224166
70MP0002876_abnormal_thyroid_physiology0.87325327
71MP0002166_altered_tumor_susceptibility0.83836864
72MP0000377_abnormal_hair_follicle0.80652282
73MP0002136_abnormal_kidney_physiology0.80286158
74MP0000465_gastrointestinal_hemorrhage0.80008224
75MP0005058_abnormal_lysosome_morphology0.75762068
76MP0005666_abnormal_adipose_tissue0.75526827
77MP0005584_abnormal_enzyme/coenzyme_acti0.75042972
78MP0003718_maternal_effect0.74147115
79MP0005023_abnormal_wound_healing0.71728641
80MP0008260_abnormal_autophagy0.71125636
81MP0004147_increased_porphyrin_level0.70443500
82MP0008872_abnormal_physiological_respon0.69693189
83MP0005166_decreased_susceptibility_to0.69490683
84MP0001845_abnormal_inflammatory_respons0.69318893
85MP0001881_abnormal_mammary_gland0.68131227
86MP0003191_abnormal_cellular_cholesterol0.67701654
87MP0000013_abnormal_adipose_tissue0.66739844
88MP0003329_amyloid_beta_deposits0.66599946
89MP0000516_abnormal_urinary_system0.66517791
90MP0005367_renal/urinary_system_phenotyp0.66517791
91MP0002971_abnormal_brown_adipose0.66074586
92MP0005165_increased_susceptibility_to0.65632749
93MP0005332_abnormal_amino_acid0.65381882
94MP0009379_abnormal_foot_pigmentation0.64311491
95MP0005448_abnormal_energy_balance0.64127054
96MP0004270_analgesia0.63933581
97MP0002118_abnormal_lipid_homeostasis0.63492986
98MP0004272_abnormal_basement_membrane0.63122892
99MP0000230_abnormal_systemic_arterial0.62647641
100MP0002896_abnormal_bone_mineralization0.59749483
101MP0002277_abnormal_respiratory_mucosa0.59385192
102MP0002006_tumorigenesis0.58230558
103MP0000627_abnormal_mammary_gland0.57328855
104MP0009642_abnormal_blood_homeostasis0.54581795
105MP0000249_abnormal_blood_vessel0.54574455
106MP0003693_abnormal_embryo_hatching0.54335973
107MP0009115_abnormal_fat_cell0.54292497
108MP0005076_abnormal_cell_differentiation0.54254260
109MP0003385_abnormal_body_wall0.52779376
110MP0009333_abnormal_splenocyte_physiolog0.52357721
111MP0000609_abnormal_liver_physiology0.52176245
112MP0000678_abnormal_parathyroid_gland0.51703546
113MP0003879_abnormal_hair_cell0.51206053
114MP0003937_abnormal_limbs/digits/tail_de0.50459501
115MP0002060_abnormal_skin_morphology0.50328525
116MP0009780_abnormal_chondrocyte_physiolo0.49726668
117MP0009384_cardiac_valve_regurgitation0.49553753
118MP0001191_abnormal_skin_condition0.45783695
119MP0000163_abnormal_cartilage_morphology0.44816873
120MP0001501_abnormal_sleep_pattern0.44117327
121MP0000383_abnormal_hair_follicle0.42249384
122MP0005187_abnormal_penis_morphology0.42237461
123MP0002138_abnormal_hepatobiliary_system0.41794191
124MP0001485_abnormal_pinna_reflex0.39449385
125MP0004185_abnormal_adipocyte_glucose0.39350444
126MP0005319_abnormal_enzyme/_coenzyme0.39259986
127MP0009931_abnormal_skin_appearance0.38818381
128MP0010771_integument_phenotype0.38521934
129MP0000579_abnormal_nail_morphology0.38389396
130MP0003638_abnormal_response/metabolism_0.38156973
131MP0002233_abnormal_nose_morphology0.37423177

Predicted human phenotypes

RankGene SetZ-score
1Flat acetabular roof (HP:0003180)6.27338139
2Posterior subcapsular cataract (HP:0007787)6.17533861
3Abnormality of the distal phalanx of the thumb (HP:0009617)5.23392563
4Ileus (HP:0002595)5.15257778
5Neonatal short-limb short stature (HP:0008921)5.11602447
6Symphalangism affecting the phalanges of the hand (HP:0009773)5.01417865
7Cupped ribs (HP:0000887)5.00118467
8Abnormality of the 1st metacarpal (HP:0010009)4.84783954
9Right ventricular cardiomyopathy (HP:0011663)4.84199097
10Flat capital femoral epiphysis (HP:0003370)4.47940968
11Decreased circulating renin level (HP:0003351)4.23238582
12Abdominal distention (HP:0003270)4.04519551
13Flattened epiphyses (HP:0003071)4.00909798
14Fragile nails (HP:0001808)3.99790299
15Abnormality of carpal bone ossification (HP:0006257)3.90593301
16Abnormality of the vitamin B12 metabolism (HP:0004341)3.78489865
17Widely patent fontanelles and sutures (HP:0004492)3.74475500
18Spinal cord compression (HP:0002176)3.70750899
19Subcapsular cataract (HP:0000523)3.70544139
20Alkalosis (HP:0001948)3.67788150
21Abnormality of monocarboxylic acid metabolism (HP:0010996)3.64089967
22Irregular epiphyses (HP:0010582)3.62678411
23Breech presentation (HP:0001623)3.56053921
24Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.55270960
25Abnormality of vitamin B metabolism (HP:0004340)3.55013282
26Hyperactive renin-angiotensin system (HP:0000841)3.50981348
27Abnormality of the proximal phalanges of the hand (HP:0009834)3.50931548
28Abnormal tarsal ossification (HP:0008369)3.45046117
29Thin bony cortex (HP:0002753)3.44269643
30Vertebral clefting (HP:0008428)3.42942090
31Vertebral hypoplasia (HP:0008417)3.41571910
32Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.41571910
33Systemic lupus erythematosus (HP:0002725)3.39709275
34Abnormality of glutamine family amino acid metabolism (HP:0010902)3.36698524
35Short middle phalanx of finger (HP:0005819)3.36326838
36Abnormal cartilage morphology (HP:0002763)3.33153821
37Short phalanx of the thumb (HP:0009660)3.32895264
38Hemorrhage of the eye (HP:0011885)3.30328674
39Confusion (HP:0001289)3.28896769
40Woolly hair (HP:0002224)3.21707579
41Abnormal vertebral ossification (HP:0100569)3.16256917
42Abnormality of the 2nd finger (HP:0004100)3.14809384
43Abnormal hair laboratory examination (HP:0003328)3.13667043
44Large earlobe (HP:0009748)3.08568130
45Abnormality of vitamin metabolism (HP:0100508)3.07182630
46Focal segmental glomerulosclerosis (HP:0000097)3.06826889
47Congenital sensorineural hearing impairment (HP:0008527)3.00731543
48Abnormality of the phalanges of the hallux (HP:0010057)2.97880688
49Malnutrition (HP:0004395)2.97047775
50Hyperparathyroidism (HP:0000843)2.94233978
51Abnormal hand bone ossification (HP:0010660)2.92620357
52Abnormal ossification of hand bones (HP:0005921)2.92318163
53Aplasia/hypoplasia of the femur (HP:0005613)2.90590639
54Abnormality of the middle phalanges of the toes (HP:0010183)2.87346823
55Abnormality of chloride homeostasis (HP:0011422)2.85183977
56Pigmentary retinal degeneration (HP:0001146)2.84505415
57Wide cranial sutures (HP:0010537)2.83896722
58Conjugated hyperbilirubinemia (HP:0002908)2.83133739
59Metabolic alkalosis (HP:0200114)2.79890465
60Pili torti (HP:0003777)2.75850091
61Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.70471514
62Hoarse voice (HP:0001609)2.68169344
63Pustule (HP:0200039)2.60598755
64Hyperuricemia (HP:0002149)2.60223963
65Increased purine levels (HP:0004368)2.60223963
66Hypoplastic ilia (HP:0000946)2.60101533
67Chronic diarrhea (HP:0002028)2.59965763
68Visceral angiomatosis (HP:0100761)2.57879298
69Alopecia of scalp (HP:0002293)2.57674080
70Hyperglycinuria (HP:0003108)2.57290827
71Absent phalangeal crease (HP:0006109)2.57264087
72Ridged nail (HP:0001807)2.56998393
73Tracheal stenosis (HP:0002777)2.55807631
74Biliary tract neoplasm (HP:0100574)2.55464497
75Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.55419713
76Nephrolithiasis (HP:0000787)2.53957571
77Xanthomatosis (HP:0000991)2.52780967
78Hyperammonemia (HP:0001987)2.52071975
79Glomerulosclerosis (HP:0000096)2.51197335
80Milia (HP:0001056)2.50802221
81Proximal tubulopathy (HP:0000114)2.50135697
82Cone-rod dystrophy (HP:0000548)2.49993415
83Short hallux (HP:0010109)2.48911131
84Hypotension (HP:0002615)2.46887113
85Abnormal foot bone ossification (HP:0010675)2.46579392
86Hydroxyprolinuria (HP:0003080)2.46047014
87Abnormality of proline metabolism (HP:0010907)2.46047014
88Breast hypoplasia (HP:0003187)2.45051899
89Pterygium (HP:0001059)2.43010294
90Nausea (HP:0002018)2.42031964
91Hypophosphatemia (HP:0002148)2.39492019
92Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.36955982
93Dehydration (HP:0001944)2.35294752
94Hyperphosphatemia (HP:0002905)2.32215592
95Hemangiomatosis (HP:0007461)2.31648437
96Hyperaldosteronism (HP:0000859)2.31277164
97Acanthocytosis (HP:0001927)2.30983202
98Abnormal biliary tract morphology (HP:0012440)2.30477089
99Micronodular cirrhosis (HP:0001413)2.28927328
100Villous atrophy (HP:0011473)2.27957775
101Abnormality of small intestinal villus morphology (HP:0011472)2.27957775
102Hip contracture (HP:0003273)2.27827972
103Lumbar hyperlordosis (HP:0002938)2.26486696
104Onycholysis (HP:0001806)2.24666238
105Aplasia/Hypoplasia of the hallux (HP:0008362)2.24164185
106Renal tubular acidosis (HP:0001947)2.23995103
107Growth hormone excess (HP:0000845)2.23866833
108Mildly elevated creatine phosphokinase (HP:0008180)2.22962281
109Proximal placement of thumb (HP:0009623)2.22449350
110Abnormality of the epiphysis of the femoral head (HP:0010574)2.20883591
111Progressive sensorineural hearing impairment (HP:0000408)2.19886608
112Shawl scrotum (HP:0000049)2.19537070
113Hyperphosphaturia (HP:0003109)2.17768951
114Coronal craniosynostosis (HP:0004440)2.17065467
115Hypobetalipoproteinemia (HP:0003563)2.17010663
116Curly hair (HP:0002212)2.16881100
117Atrophic scars (HP:0001075)2.16119558
118Gout (HP:0001997)2.15511004
119Abnormality of glycine metabolism (HP:0010895)2.13648837
120Abnormality of serine family amino acid metabolism (HP:0010894)2.13648837
121Abnormality of purine metabolism (HP:0004352)2.12994707
122Deviation of the thumb (HP:0009603)2.12043538
123Fat malabsorption (HP:0002630)2.10894239
124Polar cataract (HP:0010696)2.09946333
125Abnormal finger flexion creases (HP:0006143)2.09063283
126Steatorrhea (HP:0002570)2.07763666
127Abnormality of nucleobase metabolism (HP:0010932)2.04298482
128Delayed epiphyseal ossification (HP:0002663)2.03611107
129Abnormality of femoral epiphyses (HP:0006499)2.02183654
130Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.02183654
131Abnormality of urine glucose concentration (HP:0011016)2.01144695
132Glycosuria (HP:0003076)2.01144695
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01013391
134Protuberant abdomen (HP:0001538)2.00884137
135Late onset (HP:0003584)2.00519882
136Abnormal glucose tolerance (HP:0001952)2.00502424
137Intrahepatic cholestasis (HP:0001406)2.00206270
138Hip dysplasia (HP:0001385)2.00007082
139Short tibia (HP:0005736)1.98473020
140Short humerus (HP:0005792)1.98470590
141Enlarged epiphyses (HP:0010580)1.98172225
142Abnormality of the middle phalanges of the hand (HP:0009833)1.97940765
143Megaloblastic anemia (HP:0001889)1.97485413
144Plantar hyperkeratosis (HP:0007556)1.97056591
145Down-sloping shoulders (HP:0200021)1.96524104
146Abnormality of renin-angiotensin system (HP:0000847)1.96507963
147Abnormality of complement system (HP:0005339)1.95364193
148Hyponatremia (HP:0002902)1.94814051
149Multiple lipomas (HP:0001012)1.93815210
150Abnormality of the gastric mucosa (HP:0004295)1.93726638
151Abnormality of the nasal mucosa (HP:0000433)1.93387758
152Eczematoid dermatitis (HP:0000976)1.93313592
153Abnormal urine phosphate concentration (HP:0012599)1.91801671
154Facial shape deformation (HP:0011334)1.89745582
155Potter facies (HP:0002009)1.89745582
156Nephritis (HP:0000123)1.89517623
157Glomerulonephritis (HP:0000099)1.89026672
158Abnormality of pyrimidine metabolism (HP:0004353)1.85324901
159Dicarboxylic aciduria (HP:0003215)1.84918641
160Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84918641
161Bone pain (HP:0002653)1.84006832
162Distal lower limb amyotrophy (HP:0008944)1.83467014
163Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83014345
164Vascular calcification (HP:0004934)1.82733319
165Gastrointestinal dysmotility (HP:0002579)1.81172666
166Abnormality of the costochondral junction (HP:0000919)1.79930957
167Metabolic acidosis (HP:0001942)1.77173673
168Hypolipoproteinemia (HP:0010981)1.76529301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.87370942
2ACVR1B4.18539042
3FRK3.18239935
4RIPK13.17849197
5MST1R3.01894572
6MST42.91315936
7LMTK22.65307584
8MAP2K22.42470094
9SIK12.16075399
10EPHA22.12124259
11TAOK311.7519247
12PRKG21.97053692
13GRK61.95663669
14TRIB31.83070616
15NME11.78880544
16PIK3CA1.76236354
17PTK61.75328691
18TAOK11.70659305
19MAP3K21.66841553
20IRAK31.57727169
21KSR21.51710213
22TESK11.38226450
23PTK21.30753015
24SMG11.28681527
25MAP3K91.25629011
26STK241.23782815
27MYLK1.16894138
28ICK1.08891511
29MET0.99313179
30MAP2K10.99171887
31PRPF4B0.98957063
32ARAF0.90439350
33MAP3K140.85922598
34MAP3K100.82779437
35EPHA30.81600306
36PAK40.81524658
37RIPK40.81492867
38MAPKAPK30.79731107
39PRKCI0.79095704
40ERBB20.78560929
41MAP3K130.78553930
42ERN10.76865390
43DDR20.76174899
44FER0.73381894
45MATK0.69639324
46STK100.64876057
47NME20.63598408
48TYK20.62293653
49MAP3K80.61864158
50MAP3K10.60722256
51MAP3K120.60520133
52MAP2K60.55555222
53EPHB10.53962381
54IRAK10.53202722
55MAP4K10.51262789
56ABL20.49097586
57PDGFRA0.47061529
58NEK60.46344170
59ILK0.46060957
60CAMK2D0.45620823
61AKT30.44460061
62ERBB40.44425951
63MAPK110.42377792
64TESK20.42168634
65WNK40.41207029
66PRKAA20.40532688
67TTK0.40127829
68FGFR30.39774641
69LIMK10.38975364
70RPS6KA20.38651360
71PAK10.37533904
72EPHA40.37163256
73SRC0.36652061
74ITK0.35901856
75NUAK10.34283242
76MAP3K70.33770751
77MAPK150.33117558
78CSF1R0.32761219
79MUSK0.31585133
80MAP3K30.31112932
81RET0.30215233
82DMPK0.30133407
83TBK10.29920397
84CAMK2B0.29805825
85IRAK40.29449624
86PDPK10.27875016
87BMX0.26686554
88CAMK2G0.26614686
89LRRK20.26072869
90OXSR10.25941626
91STK110.25725262
92PKN20.24613697
93PRKCZ0.24551964
94PTK2B0.23550167
95PRKCD0.23236806
96DYRK1B0.23118639
97PAK30.23090214
98PRKCA0.23050644
99CSK0.22933183
100IRAK20.21616156
101ZAP700.21216519
102PBK0.20714548
103RPS6KB20.20510284
104MELK0.20242692
105STK390.20019005
106PIM20.19290638
107SCYL20.18775232
108PRKCQ0.18731251
109MAP3K110.18610044
110FYN0.18601464
111LATS10.18200915
112CDC42BPA0.15959839
113CHUK0.15645511
114FGFR10.15029340
115GRK10.13725523
116SIK30.13671593
117PRKAA10.13029628
118PDK10.12514382
119PRKD20.12092571
120AKT20.11189812
121CDK60.10549241
122DAPK30.10432780
123KSR10.10142429
124PDK20.09783104
125FGFR40.09108162
126WNK30.09083301
127MAPKAPK20.07590307
128RPS6KA10.07444922
129EEF2K0.07076987
130PAK20.06858421
131PRKACG0.06702316

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.08376890
2Mineral absorption_Homo sapiens_hsa049784.26658785
3Fat digestion and absorption_Homo sapiens_hsa049754.18848838
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.87842911
5Renin-angiotensin system_Homo sapiens_hsa046142.81254832
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.75120070
7Bile secretion_Homo sapiens_hsa049762.54944133
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.29667416
9Galactose metabolism_Homo sapiens_hsa000522.26203568
10Vitamin digestion and absorption_Homo sapiens_hsa049772.24203319
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05716475
12Carbohydrate digestion and absorption_Homo sapiens_hsa049731.98029284
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.94431127
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.82612607
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.82152992
16Caffeine metabolism_Homo sapiens_hsa002321.77904097
17Fructose and mannose metabolism_Homo sapiens_hsa000511.76029707
18Starch and sucrose metabolism_Homo sapiens_hsa005001.69865849
19Histidine metabolism_Homo sapiens_hsa003401.69843556
20Protein digestion and absorption_Homo sapiens_hsa049741.62287174
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55246187
22Glutathione metabolism_Homo sapiens_hsa004801.46173089
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41051845
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35655650
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34169718
26Tight junction_Homo sapiens_hsa045301.26725169
27Phenylalanine metabolism_Homo sapiens_hsa003601.19868176
28PPAR signaling pathway_Homo sapiens_hsa033201.15439594
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13062153
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12690911
31Tryptophan metabolism_Homo sapiens_hsa003801.08148343
32Folate biosynthesis_Homo sapiens_hsa007901.07968057
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.07354702
34Thyroid hormone synthesis_Homo sapiens_hsa049181.05861842
35Glycerolipid metabolism_Homo sapiens_hsa005611.05267155
36Leukocyte transendothelial migration_Homo sapiens_hsa046700.96432158
37Chemical carcinogenesis_Homo sapiens_hsa052040.93504910
38Pancreatic secretion_Homo sapiens_hsa049720.93501455
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90299169
40Pentose phosphate pathway_Homo sapiens_hsa000300.89867351
41Other glycan degradation_Homo sapiens_hsa005110.88742111
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87958262
43Fatty acid degradation_Homo sapiens_hsa000710.85948155
44Oxidative phosphorylation_Homo sapiens_hsa001900.84028049
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.80615703
46Hepatitis C_Homo sapiens_hsa051600.78631931
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78419803
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.77781393
49Asthma_Homo sapiens_hsa053100.77727288
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73363385
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73158472
52Salivary secretion_Homo sapiens_hsa049700.71782907
53Ether lipid metabolism_Homo sapiens_hsa005650.70933513
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67358432
55Butanoate metabolism_Homo sapiens_hsa006500.67224712
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66377794
57Alzheimers disease_Homo sapiens_hsa050100.65333974
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.64364269
59Linoleic acid metabolism_Homo sapiens_hsa005910.61135906
60Bladder cancer_Homo sapiens_hsa052190.60978586
61Salmonella infection_Homo sapiens_hsa051320.60638057
62Tyrosine metabolism_Homo sapiens_hsa003500.60216282
63Arginine and proline metabolism_Homo sapiens_hsa003300.58644446
64Parkinsons disease_Homo sapiens_hsa050120.58136639
65Arginine biosynthesis_Homo sapiens_hsa002200.57937262
66Sphingolipid metabolism_Homo sapiens_hsa006000.56326612
67Gastric acid secretion_Homo sapiens_hsa049710.55974485
68Adherens junction_Homo sapiens_hsa045200.54086028
69Fatty acid biosynthesis_Homo sapiens_hsa000610.53367325
70Fatty acid metabolism_Homo sapiens_hsa012120.53180951
71Carbon metabolism_Homo sapiens_hsa012000.52886193
72Thyroid cancer_Homo sapiens_hsa052160.52525392
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51644246
74TNF signaling pathway_Homo sapiens_hsa046680.48906844
75Type II diabetes mellitus_Homo sapiens_hsa049300.48778333
76Nitrogen metabolism_Homo sapiens_hsa009100.48263418
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48181136
78Insulin resistance_Homo sapiens_hsa049310.47469260
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47296189
80Biosynthesis of amino acids_Homo sapiens_hsa012300.46931527
81African trypanosomiasis_Homo sapiens_hsa051430.45801509
82Pyruvate metabolism_Homo sapiens_hsa006200.44792878
83Arachidonic acid metabolism_Homo sapiens_hsa005900.42644923
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42251508
85Allograft rejection_Homo sapiens_hsa053300.41941541
86Autoimmune thyroid disease_Homo sapiens_hsa053200.41280449
87Endometrial cancer_Homo sapiens_hsa052130.40076551
88Peroxisome_Homo sapiens_hsa041460.38984081
89ABC transporters_Homo sapiens_hsa020100.38434700
90Chronic myeloid leukemia_Homo sapiens_hsa052200.38278794
91Retinol metabolism_Homo sapiens_hsa008300.37664317
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37365134
93beta-Alanine metabolism_Homo sapiens_hsa004100.35773717
94Steroid biosynthesis_Homo sapiens_hsa001000.35690145
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33951543
96Choline metabolism in cancer_Homo sapiens_hsa052310.33869851
97Graft-versus-host disease_Homo sapiens_hsa053320.33837337
98Amoebiasis_Homo sapiens_hsa051460.32730671
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32232844
100Cardiac muscle contraction_Homo sapiens_hsa042600.31834819
101Renin secretion_Homo sapiens_hsa049240.31213948
102Pertussis_Homo sapiens_hsa051330.29864601
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29819123
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.29805055
105Toxoplasmosis_Homo sapiens_hsa051450.29695654
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28947235
107Staphylococcus aureus infection_Homo sapiens_hsa051500.28699257
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.25584108
109Metabolic pathways_Homo sapiens_hsa011000.25238265
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.24480914
111Type I diabetes mellitus_Homo sapiens_hsa049400.23480894
112Vibrio cholerae infection_Homo sapiens_hsa051100.22120711
113Antigen processing and presentation_Homo sapiens_hsa046120.22055521
114Glucagon signaling pathway_Homo sapiens_hsa049220.20120808
115Apoptosis_Homo sapiens_hsa042100.19939260
116Insulin secretion_Homo sapiens_hsa049110.19355046
117VEGF signaling pathway_Homo sapiens_hsa043700.17820620
118Huntingtons disease_Homo sapiens_hsa050160.17757835
119Sulfur relay system_Homo sapiens_hsa041220.17085235
120N-Glycan biosynthesis_Homo sapiens_hsa005100.16053211
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.15705609
122Small cell lung cancer_Homo sapiens_hsa052220.15131273
123AMPK signaling pathway_Homo sapiens_hsa041520.14378167
124Propanoate metabolism_Homo sapiens_hsa006400.13671600
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12828967
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.10387879
127Leishmaniasis_Homo sapiens_hsa051400.07101486
128GnRH signaling pathway_Homo sapiens_hsa049120.07042749
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.06471114
130Fatty acid elongation_Homo sapiens_hsa000620.02409804
131Influenza A_Homo sapiens_hsa051640.02120514

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