MITD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of ESCRT-III subunits and the C-termini binding to membranes. The encoded protein regulates ESCRT-III activity and is required for proper cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.96653139
2viral transcription (GO:0019083)4.73798416
3translational termination (GO:0006415)4.62717692
4ribosomal small subunit biogenesis (GO:0042274)4.49624816
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.15125568
6cotranslational protein targeting to membrane (GO:0006613)4.08905980
7protein targeting to ER (GO:0045047)4.04395359
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.03066510
9translational elongation (GO:0006414)3.98006186
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97775884
11ATP synthesis coupled proton transport (GO:0015986)3.93054755
12energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93054755
13maturation of SSU-rRNA (GO:0030490)3.91417984
14protein localization to endoplasmic reticulum (GO:0070972)3.88975808
15establishment of protein localization to endoplasmic reticulum (GO:0072599)3.81116546
16response to interferon-beta (GO:0035456)3.77559913
17protein complex biogenesis (GO:0070271)3.76377367
18viral life cycle (GO:0019058)3.72455905
19DNA deamination (GO:0045006)3.63121867
20proteasome assembly (GO:0043248)3.60398004
21ribosomal large subunit biogenesis (GO:0042273)3.57805377
22protein neddylation (GO:0045116)3.57532583
23mitochondrial respiratory chain complex assembly (GO:0033108)3.56704482
24signal peptide processing (GO:0006465)3.56169339
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55854437
26behavioral response to nicotine (GO:0035095)3.55682136
27respiratory chain complex IV assembly (GO:0008535)3.54910296
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.52545764
29NADH dehydrogenase complex assembly (GO:0010257)3.52545764
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52545764
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.52499875
32cellular protein complex disassembly (GO:0043624)3.51451141
33platelet dense granule organization (GO:0060155)3.50794689
34L-fucose catabolic process (GO:0042355)3.48326691
35fucose catabolic process (GO:0019317)3.48326691
36L-fucose metabolic process (GO:0042354)3.48326691
37cytochrome complex assembly (GO:0017004)3.47990564
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46786080
39cellular response to interferon-beta (GO:0035458)3.43822969
40type I interferon signaling pathway (GO:0060337)3.43273904
41cellular response to type I interferon (GO:0071357)3.43273904
42translational initiation (GO:0006413)3.43059777
43response to type I interferon (GO:0034340)3.40770253
44regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.39838241
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.33157818
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30684392
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30684392
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.28784146
49tryptophan catabolic process (GO:0006569)3.25961959
50indole-containing compound catabolic process (GO:0042436)3.25961959
51indolalkylamine catabolic process (GO:0046218)3.25961959
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.24832865
53cytidine metabolic process (GO:0046087)3.22412554
54cytidine catabolic process (GO:0006216)3.22412554
55cytidine deamination (GO:0009972)3.22412554
56antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.21344996
57DNA double-strand break processing (GO:0000729)3.20489822
58positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.20128816
59regulation of RIG-I signaling pathway (GO:0039535)3.15284856
60protein-cofactor linkage (GO:0018065)3.13833678
61protein prenylation (GO:0018342)3.11034984
62prenylation (GO:0097354)3.11034984
63translation (GO:0006412)3.10254940
64telomere maintenance via semi-conservative replication (GO:0032201)3.09279242
65rRNA modification (GO:0000154)3.07369333
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05991236
67indolalkylamine metabolic process (GO:0006586)3.02598079
68electron transport chain (GO:0022900)3.02290471
69respiratory electron transport chain (GO:0022904)3.01053610
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.99414906
71response to interferon-alpha (GO:0035455)2.98854125
72rRNA methylation (GO:0031167)2.98700341
73telomere maintenance via recombination (GO:0000722)2.98666604
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97911807
75water-soluble vitamin biosynthetic process (GO:0042364)2.96921939
76sequestering of actin monomers (GO:0042989)2.96809158
77protein complex disassembly (GO:0043241)2.96500433
78tryptophan metabolic process (GO:0006568)2.95919985
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92179173
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92179173
81positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.90747387
82response to pheromone (GO:0019236)2.90295423
83signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89923264
84signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89923264
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89923264
86kynurenine metabolic process (GO:0070189)2.89110689
87regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.88988874
88ribonucleoprotein complex biogenesis (GO:0022613)2.88641684
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85733643
90immunoglobulin mediated immune response (GO:0016064)2.84365139
91B cell mediated immunity (GO:0019724)2.81994280
92regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.81671572
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81546352
94signal transduction involved in DNA integrity checkpoint (GO:0072401)2.81176081
95signal transduction involved in DNA damage checkpoint (GO:0072422)2.81176081
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.80972910
97pyrimidine ribonucleoside catabolic process (GO:0046133)2.80791345
98signal transduction involved in cell cycle checkpoint (GO:0072395)2.80748021
99macromolecular complex disassembly (GO:0032984)2.80249851
100nuclear-transcribed mRNA catabolic process (GO:0000956)2.79719671
101negative regulation of ligase activity (GO:0051352)2.79408589
102negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79408589
103DNA strand elongation involved in DNA replication (GO:0006271)2.79131628
104mannosylation (GO:0097502)2.78237592
105termination of RNA polymerase III transcription (GO:0006386)2.76380322
106transcription elongation from RNA polymerase III promoter (GO:0006385)2.76380322
107positive regulation of interferon-alpha production (GO:0032727)2.76040015
108positive regulation of gamma-delta T cell activation (GO:0046645)2.75971721
109positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.74872914
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73983571
111isotype switching (GO:0045190)2.73850000
112somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.73850000
113somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.73850000
114rRNA processing (GO:0006364)2.72329194
115regulation of hypersensitivity (GO:0002883)2.70386451
116mRNA catabolic process (GO:0006402)2.69629082
117mitotic recombination (GO:0006312)2.69084246
1187-methylguanosine RNA capping (GO:0009452)2.68779555
119RNA capping (GO:0036260)2.68779555
1207-methylguanosine mRNA capping (GO:0006370)2.68538581
121double-strand break repair via homologous recombination (GO:0000724)2.67446136
122recombinational repair (GO:0000725)2.67424333
123CENP-A containing nucleosome assembly (GO:0034080)2.67121152
124positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.67083401
125antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.66848674
126DNA strand elongation (GO:0022616)2.65460553
127anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64675534
128formation of translation preinitiation complex (GO:0001731)2.62958693
129regulation of cellular amino acid metabolic process (GO:0006521)2.62844376
130negative regulation of viral genome replication (GO:0045071)2.62842594
131cellular response to interleukin-15 (GO:0071350)2.62654900
132telomere maintenance via telomere lengthening (GO:0010833)2.61611117
133transcription-coupled nucleotide-excision repair (GO:0006283)2.61349411
134rRNA metabolic process (GO:0016072)2.61257847
135maturation of 5.8S rRNA (GO:0000460)2.59432540
136sulfation (GO:0051923)2.59373192
137regulation of interferon-alpha production (GO:0032647)2.59271296
138preassembly of GPI anchor in ER membrane (GO:0016254)2.59052686
139histone mRNA metabolic process (GO:0008334)2.58942885
140Arp2/3 complex-mediated actin nucleation (GO:0034314)2.58714416
141T cell migration (GO:0072678)2.58083157
142DNA catabolic process, exonucleolytic (GO:0000738)2.58061660
143establishment of viral latency (GO:0019043)2.57909428
144neutrophil activation involved in immune response (GO:0002283)2.57208987
145positive regulation of defense response to virus by host (GO:0002230)2.57205471
146replication fork processing (GO:0031297)2.57115331
147protein targeting to membrane (GO:0006612)2.56421765
148regulation of mitotic spindle checkpoint (GO:1903504)2.56385069
149regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.56385069
150mast cell activation (GO:0045576)2.55987379
151adaptation of signaling pathway (GO:0023058)2.54270530
152chromatin remodeling at centromere (GO:0031055)2.52152865
153RNA-dependent DNA replication (GO:0006278)2.51386668
154respiratory burst (GO:0045730)2.51199719
155termination of RNA polymerase I transcription (GO:0006363)2.50555002
156RNA catabolic process (GO:0006401)2.50447396
157reciprocal meiotic recombination (GO:0007131)2.50380039
158reciprocal DNA recombination (GO:0035825)2.50380039
159positive regulation of alpha-beta T cell proliferation (GO:0046641)2.48913556
160rRNA catabolic process (GO:0016075)2.48154661
161interferon-gamma production (GO:0032609)2.47521417
162chaperone-mediated protein transport (GO:0072321)2.47366382
163protein polyglutamylation (GO:0018095)2.45385589
164negative regulation of telomere maintenance (GO:0032205)2.44742518
165DNA demethylation (GO:0080111)2.44326791
166spliceosomal snRNP assembly (GO:0000387)2.41975359
167tRNA processing (GO:0008033)2.41845575
168transcription from RNA polymerase I promoter (GO:0006360)2.41302888
169DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.41043822
170cellular component biogenesis (GO:0044085)2.40873800
171intracellular protein transmembrane import (GO:0044743)2.40178582
172L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.39253487
173cellular ketone body metabolic process (GO:0046950)2.38155984
174synapsis (GO:0007129)2.37878331
175antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.37725863
176antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.37725863
177kinetochore organization (GO:0051383)2.36961707
178negative regulation of DNA-dependent DNA replication (GO:2000104)2.35708778
179pseudouridine synthesis (GO:0001522)2.35493232
180amine catabolic process (GO:0009310)2.34918260
181cellular biogenic amine catabolic process (GO:0042402)2.34918260
182GPI anchor metabolic process (GO:0006505)2.32534408
183neural tube formation (GO:0001841)2.32005994
184regulation of cilium movement (GO:0003352)2.31730766
185male meiosis I (GO:0007141)2.31650755
186ATP biosynthetic process (GO:0006754)2.31521087
187regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.31391867
188detection of light stimulus involved in sensory perception (GO:0050962)2.30193001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.10344149
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.24970407
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55629040
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.51070577
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.38501154
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.37296988
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.34802020
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.34038976
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.28623677
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.24191387
11ZNF274_21170338_ChIP-Seq_K562_Hela3.13589272
12VDR_22108803_ChIP-Seq_LS180_Human2.88970950
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83860250
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77459603
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.70605570
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.70521899
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.69546837
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67391927
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.65275404
20* FLI1_27457419_Chip-Seq_LIVER_Mouse2.51995079
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50668580
22VDR_23849224_ChIP-Seq_CD4+_Human2.49901414
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47243679
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41220440
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34972414
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32961128
27ELK1_19687146_ChIP-ChIP_HELA_Human2.30150510
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28408992
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20192574
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.17705206
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16205939
32* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13533798
33* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13071518
34POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13039393
35BP1_19119308_ChIP-ChIP_Hs578T_Human2.12280805
36HOXB4_20404135_ChIP-ChIP_EML_Mouse2.11895156
37STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11559292
38IGF1R_20145208_ChIP-Seq_DFB_Human2.11085401
39MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09925301
40EWS_26573619_Chip-Seq_HEK293_Human2.09636802
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06180245
42* FOXP3_21729870_ChIP-Seq_TREG_Human2.04525456
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04477952
44FUS_26573619_Chip-Seq_HEK293_Human2.01874890
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94570162
46* SRF_21415370_ChIP-Seq_HL-1_Mouse1.93380920
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90792053
48DCP1A_22483619_ChIP-Seq_HELA_Human1.89855998
49* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89489959
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.86355474
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86028445
52SPI1_23547873_ChIP-Seq_NB4_Human1.85771974
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84965966
54XRN2_22483619_ChIP-Seq_HELA_Human1.76322644
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74711566
56P300_19829295_ChIP-Seq_ESCs_Human1.71176818
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70445192
58TAF15_26573619_Chip-Seq_HEK293_Human1.69807691
59ER_23166858_ChIP-Seq_MCF-7_Human1.63211067
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.60787353
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60409437
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58426420
63GBX2_23144817_ChIP-Seq_PC3_Human1.57878839
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56027214
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55829865
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55410750
67* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52877698
68TP53_22573176_ChIP-Seq_HFKS_Human1.52142292
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50339920
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48423376
71TTF2_22483619_ChIP-Seq_HELA_Human1.48322054
72GABP_19822575_ChIP-Seq_HepG2_Human1.46973514
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42190844
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.40924741
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39222970
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38357509
77* NFE2_27457419_Chip-Seq_LIVER_Mouse1.38269450
78NANOG_19829295_ChIP-Seq_ESCs_Human1.37737371
79SOX2_19829295_ChIP-Seq_ESCs_Human1.37737371
80* EZH2_27294783_Chip-Seq_NPCs_Mouse1.37687822
81STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36229389
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35713139
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.35123861
84* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34912476
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.34612602
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34408307
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.34408307
88FOXM1_23109430_ChIP-Seq_U2OS_Human1.33747556
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30957918
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30668334
91MYB_26560356_Chip-Seq_TH2_Human1.30626174
92* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30291966
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28277591
94GATA3_26560356_Chip-Seq_TH2_Human1.27279658
95* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27137403
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26845241
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26353379
98AR_20517297_ChIP-Seq_VCAP_Human1.26160660
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25405764
100MYC_18940864_ChIP-ChIP_HL60_Human1.25192596
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22781242
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21830014
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21611074
104CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21282682
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20488349
106BCAT_22108803_ChIP-Seq_LS180_Human1.19789570
107ELK1_22589737_ChIP-Seq_MCF10A_Human1.19307266
108NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19079316
109CBP_20019798_ChIP-Seq_JUKART_Human1.18761976
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18761976
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17263150
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16954761
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16802763
114* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16657380
115* CRX_20693478_ChIP-Seq_RETINA_Mouse1.15081794
116NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14405795
117E2F1_21310950_ChIP-Seq_MCF-7_Human1.13823425
118SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13106587
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12897806
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11695225
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11684313
122MYB_26560356_Chip-Seq_TH1_Human1.11303974
123POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10063804
124POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09434381
125* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08377098
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08345794
127* GATA3_21878914_ChIP-Seq_MCF-7_Human1.02828141
128* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01931550
129TCF4_22108803_ChIP-Seq_LS180_Human1.00552040
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99837555
131RUNX1_22412390_ChIP-Seq_EML_Mouse0.99277856
132POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99074185
133NCOR_22424771_ChIP-Seq_293T_Human0.98768567
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98576786
135* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98376878
136GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97614861
137MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97194434
138* STAT3_18555785_Chip-Seq_ESCs_Mouse0.96978749
139CIITA_25753668_ChIP-Seq_RAJI_Human0.96433052
140IRF1_19129219_ChIP-ChIP_H3396_Human0.95654521
141* P53_22387025_ChIP-Seq_ESCs_Mouse0.95637247
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95320783
143YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94397951
144SCL_19346495_ChIP-Seq_HPC-7_Human0.94132874
145ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94056858
146AR_25329375_ChIP-Seq_VCAP_Human0.93753229
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93581024
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.92367860
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92235229
150* NANOG_18555785_Chip-Seq_ESCs_Mouse0.92176203
151* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91519426
152AR_21909140_ChIP-Seq_LNCAP_Human0.91464021
153AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91186729
154FOXH1_21741376_ChIP-Seq_EPCs_Human0.90792159
155PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90608903
156MAF_26560356_Chip-Seq_TH1_Human0.90259806
157HOXB7_26014856_ChIP-Seq_BT474_Human0.90252960
158PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90164779
159TCF4_23295773_ChIP-Seq_U87_Human0.89456450
160* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88833990
161* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87665934
162FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86822298
163* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84795886
164MAF_26560356_Chip-Seq_TH2_Human0.84096377
165LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84027032
166CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82899649
167UTX_26944678_Chip-Seq_JUKART_Human0.81483342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.97133624
2MP0009785_altered_susceptibility_to3.63316245
3MP0003724_increased_susceptibility_to3.59509348
4MP0005671_abnormal_response_to3.41342009
5MP0003195_calcinosis3.21921862
6MP0003763_abnormal_thymus_physiology2.86090752
7MP0009379_abnormal_foot_pigmentation2.78917087
8MP0003693_abnormal_embryo_hatching2.77021091
9MP0002148_abnormal_hypersensitivity_rea2.62357841
10MP0005025_abnormal_response_to2.60885688
11MP0008877_abnormal_DNA_methylation2.56597828
12MP0005000_abnormal_immune_tolerance2.51845632
13MP0001800_abnormal_humoral_immune2.49208555
14MP0009333_abnormal_splenocyte_physiolog2.36586438
15MP0002723_abnormal_immune_serum2.35156738
16MP0000685_abnormal_immune_system2.32010213
17MP0002452_abnormal_antigen_presenting2.29108749
18MP0002420_abnormal_adaptive_immunity2.23708502
19MP0001819_abnormal_immune_cell2.23309935
20MP0001790_abnormal_immune_system2.18420491
21MP0005387_immune_system_phenotype2.18420491
22MP0006072_abnormal_retinal_apoptosis2.13246694
23MP0003436_decreased_susceptibility_to2.12699318
24MP0010094_abnormal_chromosome_stability2.09418955
25MP0002398_abnormal_bone_marrow2.09039385
26MP0002419_abnormal_innate_immunity2.03373228
27MP0008058_abnormal_DNA_repair2.01623407
28MP0003646_muscle_fatigue1.99828143
29MP0005551_abnormal_eye_electrophysiolog1.95154282
30MP0005645_abnormal_hypothalamus_physiol1.94313353
31MP0002006_tumorigenesis1.92636382
32MP0004957_abnormal_blastocyst_morpholog1.89973817
33MP0002166_altered_tumor_susceptibility1.89684025
34MP0000569_abnormal_digit_pigmentation1.87697396
35MP0001853_heart_inflammation1.86889246
36MP0000716_abnormal_immune_system1.86234208
37MP0005075_abnormal_melanosome_morpholog1.81141115
38MP0003077_abnormal_cell_cycle1.77914387
39MP0003186_abnormal_redox_activity1.77459970
40MP0002132_abnormal_respiratory_system1.75432746
41MP0000689_abnormal_spleen_morphology1.73374454
42MP0008007_abnormal_cellular_replicative1.72918273
43MP0005377_hearing/vestibular/ear_phenot1.72030610
44MP0003878_abnormal_ear_physiology1.72030610
45MP0006082_CNS_inflammation1.69696246
46MP0002722_abnormal_immune_system1.69055203
47MP0008057_abnormal_DNA_replication1.67573271
48MP0002396_abnormal_hematopoietic_system1.67477354
49MP0008872_abnormal_physiological_respon1.66242678
50MP0002429_abnormal_blood_cell1.65226888
51MP0002837_dystrophic_cardiac_calcinosis1.60389067
52MP0002405_respiratory_system_inflammati1.59894532
53MP0008875_abnormal_xenobiotic_pharmacok1.59741028
54MP0000858_altered_metastatic_potential1.58753880
55MP0004142_abnormal_muscle_tone1.58642071
56MP0001485_abnormal_pinna_reflex1.57705359
57MP0005397_hematopoietic_system_phenotyp1.55800853
58MP0001545_abnormal_hematopoietic_system1.55800853
59MP0005253_abnormal_eye_physiology1.53857696
60MP0004381_abnormal_hair_follicle1.53815164
61MP0005464_abnormal_platelet_physiology1.51919338
62MP0003011_delayed_dark_adaptation1.47828157
63MP0000372_irregular_coat_pigmentation1.47571381
64MP0003111_abnormal_nucleus_morphology1.47271170
65MP0001986_abnormal_taste_sensitivity1.45644264
66MP0010155_abnormal_intestine_physiology1.43700812
67MP0005174_abnormal_tail_pigmentation1.43624162
68MP0002138_abnormal_hepatobiliary_system1.43606818
69MP0002876_abnormal_thyroid_physiology1.42462650
70MP0004147_increased_porphyrin_level1.42103468
71MP0000490_abnormal_crypts_of1.39912745
72MP0001845_abnormal_inflammatory_respons1.39283007
73MP0006292_abnormal_olfactory_placode1.38064113
74MP0000703_abnormal_thymus_morphology1.37362347
75MP0000427_abnormal_hair_cycle1.33830754
76MP0003786_premature_aging1.32577794
77MP0003136_yellow_coat_color1.32295374
78MP0008469_abnormal_protein_level1.31613379
79MP0004808_abnormal_hematopoietic_stem1.30045375
80MP0002736_abnormal_nociception_after1.28159414
81MP0000465_gastrointestinal_hemorrhage1.27750433
82MP0001968_abnormal_touch/_nociception1.25575087
83MP0005389_reproductive_system_phenotype1.20787145
84MP0008932_abnormal_embryonic_tissue1.19576490
85MP0005408_hypopigmentation1.18599221
86MP0009764_decreased_sensitivity_to1.10569176
87MP0001501_abnormal_sleep_pattern1.10563391
88MP0004947_skin_inflammation1.10207157
89MP0003448_altered_tumor_morphology1.10112617
90MP0003787_abnormal_imprinting1.08091029
91MP0002160_abnormal_reproductive_system1.06234964
92MP0002019_abnormal_tumor_incidence1.05590316
93MP0000015_abnormal_ear_pigmentation1.05120651
94MP0003806_abnormal_nucleotide_metabolis1.04224625
95MP0008995_early_reproductive_senescence1.03944600
96MP0001533_abnormal_skeleton_physiology1.03705131
97MP0003866_abnormal_defecation1.02929356
98MP0005379_endocrine/exocrine_gland_phen1.02698829
99MP0000631_abnormal_neuroendocrine_gland1.02402849
100MP0002277_abnormal_respiratory_mucosa1.02122456
101MP0004742_abnormal_vestibular_system1.01555626
102MP0006054_spinal_hemorrhage1.00828604
103MP0004043_abnormal_pH_regulation0.99765545
104MP0004885_abnormal_endolymph0.98604207
105MP0001188_hyperpigmentation0.98046884
106MP0005410_abnormal_fertilization0.97901945
107MP0002933_joint_inflammation0.97093115
108MP0000313_abnormal_cell_death0.96429005
109MP0001984_abnormal_olfaction0.96256465
110MP0005646_abnormal_pituitary_gland0.96146755
111MP0002928_abnormal_bile_duct0.95578205
112MP0008789_abnormal_olfactory_epithelium0.95061932
113MP0003941_abnormal_skin_development0.94690343
114MP0001873_stomach_inflammation0.93816852
115MP0002095_abnormal_skin_pigmentation0.93005889
116MP0001529_abnormal_vocalization0.91207846
117MP0004782_abnormal_surfactant_physiolog0.91013875
118MP0002234_abnormal_pharynx_morphology0.90997665
119MP0009046_muscle_twitch0.90651682
120MP0010386_abnormal_urinary_bladder0.89751801
121MP0003718_maternal_effect0.89708815
122MP0002254_reproductive_system_inflammat0.87974992
123MP0002163_abnormal_gland_morphology0.87084438
124MP0009763_increased_sensitivity_to0.86697054
125MP0002102_abnormal_ear_morphology0.86032735
126MP0002938_white_spotting0.85470899
127MP0001542_abnormal_bone_strength0.83173381
128MP0002638_abnormal_pupillary_reflex0.83117824
129MP0001486_abnormal_startle_reflex0.82879368
130MP0002693_abnormal_pancreas_physiology0.82794201
131MP0009745_abnormal_behavioral_response0.80391210
132MP0001929_abnormal_gametogenesis0.79028125
133MP0001324_abnormal_eye_pigmentation0.78650487
134MP0003252_abnormal_bile_duct0.78462825
135MP0000343_altered_response_to0.77361901
136MP0005195_abnormal_posterior_eye0.76472274
137MP0006035_abnormal_mitochondrial_morpho0.76196219
138MP0006036_abnormal_mitochondrial_physio0.75033581
139MP0004133_heterotaxia0.74197579
140MP0005171_absent_coat_pigmentation0.71867568
141MP0003943_abnormal_hepatobiliary_system0.71251992
142MP0005084_abnormal_gallbladder_morpholo0.68122585
143MP0001879_abnormal_lymphatic_vessel0.67716572
144MP0000350_abnormal_cell_proliferation0.67128526
145MP0003656_abnormal_erythrocyte_physiolo0.64172855
146MP0009278_abnormal_bone_marrow0.64076633
147MP0001764_abnormal_homeostasis0.62871341
148MP0001119_abnormal_female_reproductive0.62298414
149MP0009697_abnormal_copulation0.61495783
150MP0001919_abnormal_reproductive_system0.61407004
151MP0009765_abnormal_xenobiotic_induced0.59372737

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.65931894
2Abnormal number of erythroid precursors (HP:0012131)4.51526175
3Elevated erythrocyte sedimentation rate (HP:0003565)4.18598308
4Reticulocytopenia (HP:0001896)4.02549238
5Pancreatic cysts (HP:0001737)3.78816027
6Aplastic anemia (HP:0001915)3.65079126
7Increased IgM level (HP:0003496)3.55382178
8IgM deficiency (HP:0002850)3.53045988
9Recurrent abscess formation (HP:0002722)3.44522166
10Pancreatic fibrosis (HP:0100732)3.27509234
11True hermaphroditism (HP:0010459)3.21100840
12IgG deficiency (HP:0004315)3.20410996
13Congenital stationary night blindness (HP:0007642)3.17569310
143-Methylglutaconic aciduria (HP:0003535)3.06357978
15Molar tooth sign on MRI (HP:0002419)3.05375650
16Abnormality of midbrain morphology (HP:0002418)3.05375650
17Pallor (HP:0000980)3.04351359
18Abnormality of the renal cortex (HP:0011035)3.02698570
19Attenuation of retinal blood vessels (HP:0007843)3.00622583
20Eczematoid dermatitis (HP:0000976)3.00023599
21Progressive macrocephaly (HP:0004481)2.94872614
22Type I transferrin isoform profile (HP:0003642)2.90436429
23Nephronophthisis (HP:0000090)2.88512870
24Myositis (HP:0100614)2.84669976
25Increased hepatocellular lipid droplets (HP:0006565)2.84664956
26Recurrent bacterial skin infections (HP:0005406)2.84374387
27Renal cortical cysts (HP:0000803)2.84150369
28Thrombocytosis (HP:0001894)2.83847295
29Abnormality of T cell number (HP:0011839)2.81463364
30Acute encephalopathy (HP:0006846)2.80950792
31Macrocytic anemia (HP:0001972)2.80724562
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80364623
33Stomach cancer (HP:0012126)2.79251145
34Pendular nystagmus (HP:0012043)2.78840079
35Abnormal rod and cone electroretinograms (HP:0008323)2.76350998
36Abnormal mitochondria in muscle tissue (HP:0008316)2.75827952
37Birth length less than 3rd percentile (HP:0003561)2.73752337
38Petechiae (HP:0000967)2.71018907
39Exertional dyspnea (HP:0002875)2.69867467
40Autoimmune thrombocytopenia (HP:0001973)2.69718796
41T lymphocytopenia (HP:0005403)2.68596465
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.67397960
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.66962876
44Patchy hypopigmentation of hair (HP:0011365)2.66596355
45Recurrent bronchitis (HP:0002837)2.63302095
46Abnormality of T cells (HP:0002843)2.61972223
47Retrobulbar optic neuritis (HP:0100654)2.61259423
48Optic neuritis (HP:0100653)2.61259423
49Abolished electroretinogram (ERG) (HP:0000550)2.60627978
50Vasculitis (HP:0002633)2.60378605
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.60209775
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.60209775
53Autoimmune hemolytic anemia (HP:0001890)2.58992107
54Lymphopenia (HP:0001888)2.57190581
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56137284
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.53792659
57Orchitis (HP:0100796)2.53568395
58Medial flaring of the eyebrow (HP:0010747)2.53544255
59Mitochondrial inheritance (HP:0001427)2.50956705
60Abnormality of the renal medulla (HP:0100957)2.48894227
61Renal Fanconi syndrome (HP:0001994)2.43189789
62Obstructive lung disease (HP:0006536)2.42831982
63Chronic obstructive pulmonary disease (HP:0006510)2.42831982
64Lipid accumulation in hepatocytes (HP:0006561)2.42675737
65Mediastinal lymphadenopathy (HP:0100721)2.41640948
66Severe combined immunodeficiency (HP:0004430)2.40875259
67Methylmalonic acidemia (HP:0002912)2.36102469
68Abnormality of T cell physiology (HP:0011840)2.35744940
69Sparse eyelashes (HP:0000653)2.30809479
70Hepatocellular necrosis (HP:0001404)2.30730371
71Respiratory difficulties (HP:0002880)2.30515076
72Reduced antithrombin III activity (HP:0001976)2.30130423
73Optic disc pallor (HP:0000543)2.29618047
74Combined immunodeficiency (HP:0005387)2.28749011
75Granulocytopenia (HP:0001913)2.27719851
76Decreased central vision (HP:0007663)2.27060915
77Recurrent viral infections (HP:0004429)2.26853579
78Abnormality of macrophages (HP:0004311)2.26746458
79Stomatitis (HP:0010280)2.25777376
80Hypergammaglobulinemia (HP:0010702)2.23767774
81Chronic otitis media (HP:0000389)2.22248667
82Vacuolated lymphocytes (HP:0001922)2.22077282
83Eosinophilia (HP:0001880)2.21047586
84Recurrent fungal infections (HP:0002841)2.18966777
85Pancytopenia (HP:0001876)2.18772024
86Colon cancer (HP:0003003)2.18590451
87Abnormality of the heme biosynthetic pathway (HP:0010472)2.16751969
88Lymphoma (HP:0002665)2.16271999
89Neutropenia (HP:0001875)2.14457690
90IgA deficiency (HP:0002720)2.13018810
91Type II lissencephaly (HP:0007260)2.12144222
92Abnormality of eosinophils (HP:0001879)2.11888922
9311 pairs of ribs (HP:0000878)2.10103930
94Cleft eyelid (HP:0000625)2.10061674
95Leukocytosis (HP:0001974)2.09335195
96Thyroiditis (HP:0100646)2.08845012
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08517463
98Abnormality of alanine metabolism (HP:0010916)2.08517463
99Hyperalaninemia (HP:0003348)2.08517463
100Acute necrotizing encephalopathy (HP:0006965)2.08439490
101Recurrent skin infections (HP:0001581)2.08292718
102Hyperglycinemia (HP:0002154)2.06207675
103Increased CSF lactate (HP:0002490)2.05777250
104Amaurosis fugax (HP:0100576)2.05146704
105Abnormal protein N-linked glycosylation (HP:0012347)2.04635347
106Abnormal protein glycosylation (HP:0012346)2.04635347
107Abnormal glycosylation (HP:0012345)2.04635347
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04635347
109Meningitis (HP:0001287)2.04175006
110Oral leukoplakia (HP:0002745)2.03457344
111Hypoproteinemia (HP:0003075)2.02988164
112Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01613325
113Methylmalonic aciduria (HP:0012120)2.00367505
114Chromsome breakage (HP:0040012)2.00292600
115Cerebral edema (HP:0002181)2.00128712
116Hypoplasia of the pons (HP:0012110)1.99632113
117Tubular atrophy (HP:0000092)1.97210441
118Hepatosplenomegaly (HP:0001433)1.96863365
119Abnormality of the pons (HP:0007361)1.96168844
120Increased serum lactate (HP:0002151)1.95121036
121Chronic mucocutaneous candidiasis (HP:0002728)1.95014232
122Recurrent cutaneous fungal infections (HP:0011370)1.95014232
123Pulmonary fibrosis (HP:0002206)1.94986686
124Hepatic necrosis (HP:0002605)1.94937821
125Poor head control (HP:0002421)1.94639976
126Nausea (HP:0002018)1.94390910
127Poikiloderma (HP:0001029)1.94264330
128Hypothermia (HP:0002045)1.93141909
129Chronic hepatic failure (HP:0100626)1.92795874
130B lymphocytopenia (HP:0010976)1.91248798
131Abnormality of B cell number (HP:0010975)1.91248798
132Prolonged bleeding time (HP:0003010)1.90543656
133Anencephaly (HP:0002323)1.89984248
134Abnormality of the prostate (HP:0008775)1.88752866
135Encephalitis (HP:0002383)1.88341061
136Sclerocornea (HP:0000647)1.88170312
137Abnormality of the axillary hair (HP:0100134)1.88131297
138Abnormality of secondary sexual hair (HP:0009888)1.88131297
139Basal ganglia calcification (HP:0002135)1.87297776
140Congenital, generalized hypertrichosis (HP:0004540)1.86865225
141Abnormality of macular pigmentation (HP:0008002)1.86686417
142Lactic acidosis (HP:0003128)1.86467459
143Keratoconus (HP:0000563)1.85840371
144Increased corneal curvature (HP:0100692)1.85840371
145Cellular immunodeficiency (HP:0005374)1.84377932
146Abnormality of renal resorption (HP:0011038)1.84125384
147Cystic liver disease (HP:0006706)1.83750695
148Chronic sinusitis (HP:0011109)1.82981803
149Large for gestational age (HP:0001520)1.82304175
150Polydipsia (HP:0001959)1.82046445
151Abnormal drinking behavior (HP:0030082)1.82046445
152Congenital primary aphakia (HP:0007707)1.80783825
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.80459023
154Increased intramyocellular lipid droplets (HP:0012240)1.80385573
155Abnormal biliary tract physiology (HP:0012439)1.80099904
156Bile duct proliferation (HP:0001408)1.80099904
157Abnormality of urine glucose concentration (HP:0011016)1.77758026
158Glycosuria (HP:0003076)1.77758026
159Abnormal albumin level (HP:0012116)1.76193698
160Hypoalbuminemia (HP:0003073)1.76193698
161Furrowed tongue (HP:0000221)1.75924374
162Aplasia/Hypoplasia of the uvula (HP:0010293)1.73703564
163Constricted visual fields (HP:0001133)1.72641181
164Aplasia/Hypoplasia of the tibia (HP:0005772)1.70895741
165Aplasia/Hypoplasia of the spleen (HP:0010451)1.70438938
166Lethargy (HP:0001254)1.69520506
167Gait imbalance (HP:0002141)1.68675094
168Nephrogenic diabetes insipidus (HP:0009806)1.67642254
169Hypoplasia of the fovea (HP:0007750)1.67492054
170Aplasia/Hypoplasia of the fovea (HP:0008060)1.67492054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.47567054
2NME23.44700561
3TAOK32.95438006
4MAP4K22.92783164
5TXK2.73848076
6BUB12.63069508
7PBK2.59996277
8IRAK42.59672754
9EIF2AK12.59313085
10MAP3K142.56924991
11MAP3K122.55326100
12TLK12.54724362
13WNK32.45589509
14IKBKE2.39807810
15SRPK12.37977938
16VRK12.37666419
17MAP4K12.31690734
18INSRR2.28755924
19MST42.27344117
20STK162.23913202
21KDR1.97552703
22WEE11.94906483
23PLK41.89315956
24JAK31.88924948
25TYK21.86499866
26TEC1.84038609
27PIM21.82005331
28ACVR1B1.81350283
29EIF2AK31.74459041
30BLK1.63029326
31TRIM281.58567029
32TBK11.58398396
33KIT1.55490557
34TIE11.46623519
35IKBKB1.45151395
36TGFBR11.38173227
37EIF2AK21.37712718
38BTK1.36037395
39ZAP701.34492142
40TNIK1.33035793
41WNK41.31270170
42TESK21.27997992
43PINK11.23321339
44OXSR11.23018398
45NLK1.22614158
46BRSK21.17978794
47BMPR1B1.11367501
48RPS6KA41.09521497
49RPS6KB21.09304271
50PASK1.08510218
51STK41.08388795
52MAP3K41.07314145
53ADRBK11.03293614
54VRK21.02764363
55BCKDK1.02182868
56CDC70.99501666
57LCK0.97714128
58LYN0.97284127
59BMPR20.95422184
60MKNK10.91919132
61TSSK60.91892103
62GRK70.90909694
63MAPK130.90388990
64CASK0.88785920
65SYK0.88149258
66STK100.88052400
67IRAK30.86591986
68MAP3K130.85775446
69ERBB30.85270886
70ADRBK20.83116835
71PRKCQ0.82738260
72PLK20.80497453
73ZAK0.80065213
74GRK60.79539727
75NEK90.79131002
76PIK3CG0.78295115
77PIM10.76151480
78STK390.75897822
79ARAF0.75716766
80MYLK0.75114805
81JAK10.72890945
82AURKB0.71464591
83PLK10.66975756
84ATR0.66369869
85CAMKK20.65266479
86CLK10.62798547
87BCR0.62656295
88CHUK0.62471672
89TRPM70.60684835
90DYRK20.60603742
91MAPKAPK50.60525309
92PRKCG0.60315997
93MAP3K30.60304126
94YES10.60224143
95PRKCE0.60060711
96MARK30.59896265
97PLK30.59556646
98PAK30.58414532
99LIMK10.58166209
100RPS6KA50.58136670
101GRK10.57667393
102MUSK0.57506030
103BRAF0.56685477
104CSNK2A10.56193926
105ABL20.55857379
106MAP2K30.55398620
107STK240.55212857
108MKNK20.54961284
109CDK70.54411638
110CSF1R0.53805627
111ITK0.53779347
112NEK10.53310740
113NME10.52054522
114TNK20.52000813
115STK38L0.51109631
116BRSK10.49375581
117MAP2K70.48991197
118NEK20.48236838
119MAP2K60.47873455
120NUAK10.47504875
121CDK80.47141194
122TGFBR20.46234419
123LRRK20.45742655
124IRAK20.45540015
125MAPKAPK20.44851495
126CDK190.44208183
127CSK0.43897147
128FLT30.43871625
129MAPKAPK30.43597686
130FGFR40.43397667
131AURKA0.42137767
132CSNK2A20.41175442
133IRAK10.40455681
134CSNK1G20.38829660
135PRKACA0.38633590
136CSNK1G10.38010574
137TESK10.37574948
138IGF1R0.36997085
139STK30.35420689
140GRK50.34665912
141PIK3CA0.34612385
142PRKCA0.31345491
143TAF10.30733927
144PRKCI0.30356220
145FES0.30280696

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.47822620
2Proteasome_Homo sapiens_hsa030503.67853166
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.01892664
4DNA replication_Homo sapiens_hsa030303.01559218
5RNA polymerase_Homo sapiens_hsa030202.89916480
6Mismatch repair_Homo sapiens_hsa034302.66956031
7Primary immunodeficiency_Homo sapiens_hsa053402.30098412
8Spliceosome_Homo sapiens_hsa030402.29071084
9Caffeine metabolism_Homo sapiens_hsa002322.21462077
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15324802
11Homologous recombination_Homo sapiens_hsa034402.13126705
12Pyrimidine metabolism_Homo sapiens_hsa002402.08822519
13Nucleotide excision repair_Homo sapiens_hsa034202.08227087
14Graft-versus-host disease_Homo sapiens_hsa053321.96354422
15Base excision repair_Homo sapiens_hsa034101.85335602
16Phototransduction_Homo sapiens_hsa047441.85252448
17Protein export_Homo sapiens_hsa030601.84072978
18Allograft rejection_Homo sapiens_hsa053301.72019490
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69778505
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.63204703
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62844670
22Measles_Homo sapiens_hsa051621.61884389
23Non-homologous end-joining_Homo sapiens_hsa034501.57556074
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.53823708
25Basal transcription factors_Homo sapiens_hsa030221.52059220
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50666323
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.50491331
28Nitrogen metabolism_Homo sapiens_hsa009101.49723409
29RNA degradation_Homo sapiens_hsa030181.48966288
30Herpes simplex infection_Homo sapiens_hsa051681.46024243
31Antigen processing and presentation_Homo sapiens_hsa046121.45473058
32Fanconi anemia pathway_Homo sapiens_hsa034601.44788963
33Selenocompound metabolism_Homo sapiens_hsa004501.44267268
34Oxidative phosphorylation_Homo sapiens_hsa001901.42591190
35RNA transport_Homo sapiens_hsa030131.40554670
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36929169
37Butanoate metabolism_Homo sapiens_hsa006501.36586110
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34243226
39Hematopoietic cell lineage_Homo sapiens_hsa046401.29856250
40Parkinsons disease_Homo sapiens_hsa050121.29421087
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28556494
42Leishmaniasis_Homo sapiens_hsa051401.26721780
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25823007
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17960731
45Tryptophan metabolism_Homo sapiens_hsa003801.15565929
46Propanoate metabolism_Homo sapiens_hsa006401.13662418
47Legionellosis_Homo sapiens_hsa051341.13492413
48Cell cycle_Homo sapiens_hsa041101.10890530
49Asthma_Homo sapiens_hsa053101.07727916
50Autoimmune thyroid disease_Homo sapiens_hsa053201.06716219
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06561782
52Influenza A_Homo sapiens_hsa051641.06352074
53Peroxisome_Homo sapiens_hsa041461.04446759
54Purine metabolism_Homo sapiens_hsa002301.03618754
55Huntingtons disease_Homo sapiens_hsa050161.03392592
56Epstein-Barr virus infection_Homo sapiens_hsa051691.01769614
57p53 signaling pathway_Homo sapiens_hsa041150.99194947
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98786607
59Malaria_Homo sapiens_hsa051440.95824558
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94081666
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93834777
62Cardiac muscle contraction_Homo sapiens_hsa042600.91917815
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91567563
64Rheumatoid arthritis_Homo sapiens_hsa053230.90889553
65Pertussis_Homo sapiens_hsa051330.90833286
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90522068
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.88131442
68One carbon pool by folate_Homo sapiens_hsa006700.86607785
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86111881
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85226389
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83677670
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83572279
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83560005
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81859649
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80451578
76Shigellosis_Homo sapiens_hsa051310.79586501
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79551643
78Alzheimers disease_Homo sapiens_hsa050100.78627833
79Regulation of autophagy_Homo sapiens_hsa041400.77701778
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.76835788
81Olfactory transduction_Homo sapiens_hsa047400.74994371
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74939887
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73224548
84Sulfur metabolism_Homo sapiens_hsa009200.72777818
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.72269629
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69703533
87Apoptosis_Homo sapiens_hsa042100.69162357
88Nicotine addiction_Homo sapiens_hsa050330.66818189
89T cell receptor signaling pathway_Homo sapiens_hsa046600.65379672
90Systemic lupus erythematosus_Homo sapiens_hsa053220.64842390
91Type I diabetes mellitus_Homo sapiens_hsa049400.63462833
92Retinol metabolism_Homo sapiens_hsa008300.63223921
93ABC transporters_Homo sapiens_hsa020100.62100667
94Taste transduction_Homo sapiens_hsa047420.61773530
95Hepatitis B_Homo sapiens_hsa051610.60605712
96African trypanosomiasis_Homo sapiens_hsa051430.59868971
97Other glycan degradation_Homo sapiens_hsa005110.59460050
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58033448
99Arachidonic acid metabolism_Homo sapiens_hsa005900.57528079
100TNF signaling pathway_Homo sapiens_hsa046680.56751771
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.54734635
102Hepatitis C_Homo sapiens_hsa051600.54427135
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53756716
104Salmonella infection_Homo sapiens_hsa051320.53726205
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53470740
106Osteoclast differentiation_Homo sapiens_hsa043800.53377820
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52771663
108Staphylococcus aureus infection_Homo sapiens_hsa051500.52550944
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52131512
110Folate biosynthesis_Homo sapiens_hsa007900.51519243
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.50856518
112Viral myocarditis_Homo sapiens_hsa054160.50437714
113Sulfur relay system_Homo sapiens_hsa041220.48106067
114Pentose phosphate pathway_Homo sapiens_hsa000300.46937983
115Tuberculosis_Homo sapiens_hsa051520.46903718
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46692116
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46627706
118Toxoplasmosis_Homo sapiens_hsa051450.45689137
119Glutathione metabolism_Homo sapiens_hsa004800.44977950
120B cell receptor signaling pathway_Homo sapiens_hsa046620.44553320
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43831080
122Viral carcinogenesis_Homo sapiens_hsa052030.42315904
123Morphine addiction_Homo sapiens_hsa050320.39863616
124mRNA surveillance pathway_Homo sapiens_hsa030150.39306812
125Glycerolipid metabolism_Homo sapiens_hsa005610.38713288
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37335370
127Collecting duct acid secretion_Homo sapiens_hsa049660.33596682
128Phagosome_Homo sapiens_hsa041450.33384310
129HTLV-I infection_Homo sapiens_hsa051660.31978369
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.30786092
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29300237
132Chemical carcinogenesis_Homo sapiens_hsa052040.28845187
133Chemokine signaling pathway_Homo sapiens_hsa040620.27842451
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27625888
135Ether lipid metabolism_Homo sapiens_hsa005650.27416201
136Linoleic acid metabolism_Homo sapiens_hsa005910.25386545
137Metabolic pathways_Homo sapiens_hsa011000.24886846
138Sphingolipid metabolism_Homo sapiens_hsa006000.24660303

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