MIXL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1otic vesicle formation (GO:0030916)8.90940714
2epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)8.58625977
3vitamin catabolic process (GO:0009111)8.19945186
4fat-soluble vitamin catabolic process (GO:0042363)8.19945186
5* regulation of mesoderm development (GO:2000380)7.55016680
6secondary heart field specification (GO:0003139)7.42025654
7heart field specification (GO:0003128)7.42025654
8primitive streak formation (GO:0090009)7.32116313
9* gastrulation (GO:0007369)6.92996932
10regulation of Wnt signaling pathway involved in heart development (GO:0003307)6.04015457
11positive regulation of gastrulation (GO:2000543)6.00372521
12nodal signaling pathway (GO:0038092)5.60493113
13negative regulation of cell fate specification (GO:0009996)5.48572694
14lung morphogenesis (GO:0060425)5.46204003
15DNA deamination (GO:0045006)5.33629290
16behavioral response to nicotine (GO:0035095)5.29176057
17somite rostral/caudal axis specification (GO:0032525)5.17299705
18mesonephros development (GO:0001823)5.16192412
19branching involved in salivary gland morphogenesis (GO:0060445)4.85502140
20forebrain morphogenesis (GO:0048853)4.81877308
21aorta morphogenesis (GO:0035909)4.75564840
22anterior/posterior axis specification (GO:0009948)4.69029005
23anterior/posterior axis specification, embryo (GO:0008595)4.63045543
24regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.61768910
25organ induction (GO:0001759)4.58477191
26specification of organ identity (GO:0010092)4.55577326
27endoderm formation (GO:0001706)4.53918483
28cell migration involved in heart development (GO:0060973)4.41358830
29establishment of integrated proviral latency (GO:0075713)4.40532287
30outflow tract septum morphogenesis (GO:0003148)4.33342696
31embryonic retina morphogenesis in camera-type eye (GO:0060059)4.26422098
32water-soluble vitamin biosynthetic process (GO:0042364)4.19602815
33cardiac epithelial to mesenchymal transition (GO:0060317)4.19269159
34negative regulation of cardiac muscle tissue development (GO:0055026)4.15137969
35single strand break repair (GO:0000012)4.10705377
36ribosome assembly (GO:0042255)4.10513741
37regulation of gastrulation (GO:0010470)4.01692222
38vagina development (GO:0060068)4.01575471
39Notch signaling involved in heart development (GO:0061314)3.99197937
40cell proliferation in forebrain (GO:0021846)3.98960145
41L-serine metabolic process (GO:0006563)3.92577579
42piRNA metabolic process (GO:0034587)3.92107923
43ventricular trabecula myocardium morphogenesis (GO:0003222)3.82091064
44positive regulation of cell size (GO:0045793)3.77558987
45negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.76065810
46folic acid-containing compound biosynthetic process (GO:0009396)3.75118711
47head development (GO:0060322)3.74893585
48morphogenesis of embryonic epithelium (GO:0016331)3.73115777
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.72096759
50negative regulation of embryonic development (GO:0045992)3.68707418
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.67122552
52negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.61763026
53negative regulation of cell fate commitment (GO:0010454)3.60583938
54maturation of SSU-rRNA (GO:0030490)3.60229381
55DNA unwinding involved in DNA replication (GO:0006268)3.54962784
56mitotic metaphase plate congression (GO:0007080)3.49346812
57rRNA catabolic process (GO:0016075)3.48915125
58motor neuron axon guidance (GO:0008045)3.48825300
59fucose catabolic process (GO:0019317)3.48759496
60L-fucose metabolic process (GO:0042354)3.48759496
61L-fucose catabolic process (GO:0042355)3.48759496
62female genitalia development (GO:0030540)3.45753914
63gastrulation with mouth forming second (GO:0001702)3.44185876
64negative regulation of androgen receptor signaling pathway (GO:0060766)3.43369382
65regulation of meiosis I (GO:0060631)3.43231096
66dopaminergic neuron differentiation (GO:0071542)3.43203709
67retinal cone cell development (GO:0046549)3.42169755
68sequestering of extracellular ligand from receptor (GO:0035581)3.40383199
69glandular epithelial cell differentiation (GO:0002067)3.35891720
70glomerulus development (GO:0032835)3.35645409
71heart trabecula morphogenesis (GO:0061384)3.33859279
72embryonic viscerocranium morphogenesis (GO:0048703)3.33381089
73cardiac ventricle formation (GO:0003211)3.32834849
74somite development (GO:0061053)3.31655228
75serine family amino acid biosynthetic process (GO:0009070)3.31462718
76kynurenine metabolic process (GO:0070189)3.30085585
77nucleobase biosynthetic process (GO:0046112)3.30002294
78spliceosomal snRNP assembly (GO:0000387)3.29180213
79kidney morphogenesis (GO:0060993)3.28966659
80pharyngeal system development (GO:0060037)3.28963558
81purine nucleobase biosynthetic process (GO:0009113)3.28399881
82establishment of viral latency (GO:0019043)3.27631064
83protein polyglutamylation (GO:0018095)3.27246358
84negative regulation of transcription regulatory region DNA binding (GO:2000678)3.25975689
85regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.25541309
86ribosome biogenesis (GO:0042254)3.24261609
87negative regulation of activin receptor signaling pathway (GO:0032926)3.23558759
88indolalkylamine metabolic process (GO:0006586)3.22795998
89trophoblast giant cell differentiation (GO:0060707)3.22207190
90DNA strand elongation involved in DNA replication (GO:0006271)3.21867828
91regulation of cell fate specification (GO:0042659)3.20518423
92male genitalia development (GO:0030539)3.20171210
93paraxial mesoderm development (GO:0048339)3.19084522
94multicellular organism reproduction (GO:0032504)3.17621152
95cell surface receptor signaling pathway involved in heart development (GO:0061311)3.15257603
96tryptophan catabolic process (GO:0006569)3.15023799
97indole-containing compound catabolic process (GO:0042436)3.15023799
98indolalkylamine catabolic process (GO:0046218)3.15023799
99urogenital system development (GO:0001655)3.09954928
100response to pheromone (GO:0019236)3.07733515
101preassembly of GPI anchor in ER membrane (GO:0016254)3.04907331
102cardiac chamber formation (GO:0003207)3.04843537
103DNA methylation involved in gamete generation (GO:0043046)3.04518545
104DNA replication initiation (GO:0006270)3.03470636
105DNA replication checkpoint (GO:0000076)3.02259282
106positive regulation of meiosis (GO:0045836)3.01945055
107forebrain neuron development (GO:0021884)3.01637991
108ribonucleoprotein complex biogenesis (GO:0022613)3.01349881
109embryonic axis specification (GO:0000578)3.00264637
110cardiac right ventricle morphogenesis (GO:0003215)2.99679182
111neural crest cell development (GO:0014032)2.98277975
112DNA strand elongation (GO:0022616)2.97617485
113synapsis (GO:0007129)2.96395480
114viral transcription (GO:0019083)2.96222698
115regulation of tight junction assembly (GO:2000810)2.95593915
116detection of light stimulus involved in visual perception (GO:0050908)2.95480227
117detection of light stimulus involved in sensory perception (GO:0050962)2.95480227
118regulation of translational termination (GO:0006449)2.93632387
119uterus development (GO:0060065)2.93052775
120formation of translation preinitiation complex (GO:0001731)2.92572731
121somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89084550
122isotype switching (GO:0045190)2.89084550
123somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89084550
124ribosomal small subunit biogenesis (GO:0042274)2.88947998
125cytidine deamination (GO:0009972)2.88787448
126cytidine metabolic process (GO:0046087)2.88787448
127cytidine catabolic process (GO:0006216)2.88787448
128protein localization to kinetochore (GO:0034501)2.87854609
129sulfation (GO:0051923)2.87681243
130translational termination (GO:0006415)2.87630756
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87235305
132regulation of acrosome reaction (GO:0060046)2.86747782
133proteasome assembly (GO:0043248)2.86599280
134cartilage morphogenesis (GO:0060536)2.86519461
135DNA replication-dependent nucleosome assembly (GO:0006335)2.85824927
136negative regulation of mast cell activation (GO:0033004)2.84338834
137negative regulation of telomere maintenance (GO:0032205)2.83791318
138positive regulation of meiotic cell cycle (GO:0051446)2.80299391
139positive regulation of defense response to virus by host (GO:0002230)2.78730244
140axoneme assembly (GO:0035082)2.78019032
141DNA double-strand break processing (GO:0000729)2.76337961
142detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73792158
143tryptophan metabolic process (GO:0006568)2.73777208
144replication fork processing (GO:0031297)2.73005178
145tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.72981237
146RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.72981237
147GPI anchor metabolic process (GO:0006505)2.72574765
148respiratory chain complex IV assembly (GO:0008535)2.71981354
149cellular response to ATP (GO:0071318)2.69909045
150nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69442099
151exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67621033
152negative regulation of T cell differentiation in thymus (GO:0033085)2.65137258
153regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65001572
154regulation of mitotic spindle checkpoint (GO:1903504)2.65001572
155mitochondrial respiratory chain complex I assembly (GO:0032981)2.64527938
156NADH dehydrogenase complex assembly (GO:0010257)2.64527938
157mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64527938
158negative regulation of astrocyte differentiation (GO:0048712)2.63171558
159protein complex biogenesis (GO:0070271)2.62953372
160double-strand break repair via homologous recombination (GO:0000724)2.62872694
161ncRNA catabolic process (GO:0034661)2.62264481
162recombinational repair (GO:0000725)2.62086265
163regulation of hippo signaling (GO:0035330)2.61228112
164magnesium ion transport (GO:0015693)2.58625017
165epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58315517
166adaptation of signaling pathway (GO:0023058)2.58278200
167gamma-aminobutyric acid transport (GO:0015812)2.55807791
168protein neddylation (GO:0045116)2.55160840
169male meiosis I (GO:0007141)2.54840705
170organ formation (GO:0048645)2.53493986
171centriole replication (GO:0007099)2.53003919
172platelet dense granule organization (GO:0060155)2.52335362
173regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52123352
174DNA demethylation (GO:0080111)2.51607747
175cornea development in camera-type eye (GO:0061303)2.50775710
176mannosylation (GO:0097502)2.48951022
177positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.47117948
178mitochondrial respiratory chain complex assembly (GO:0033108)2.46923750
179indole-containing compound metabolic process (GO:0042430)2.45758077
180chromatin remodeling at centromere (GO:0031055)2.44817267
181regulation of glomerulus development (GO:0090192)2.44274502
182aggressive behavior (GO:0002118)2.43765015
183negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.43474505
184epithelial cilium movement (GO:0003351)2.43009774
185pyrimidine ribonucleoside catabolic process (GO:0046133)2.42805628
186negative regulation of DNA-dependent DNA replication (GO:2000104)2.42754854
187photoreceptor cell development (GO:0042461)2.42315108
188positive regulation of fatty acid transport (GO:2000193)2.42192775
189rhodopsin mediated signaling pathway (GO:0016056)2.40324251
190regulation of nuclear cell cycle DNA replication (GO:0033262)2.40323181
191regulation of action potential (GO:0098900)2.38962831
192positive regulation of prostaglandin secretion (GO:0032308)2.37524757
193* cell migration involved in gastrulation (GO:0042074)11.7044858
194signal transduction involved in regulation of gene expression (GO:0023019)10.0803446

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.67266395
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.96960602
3EZH2_22144423_ChIP-Seq_EOC_Human4.27324210
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.76946382
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.63245277
6ZNF274_21170338_ChIP-Seq_K562_Hela3.47358877
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.40611582
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18770160
9VDR_22108803_ChIP-Seq_LS180_Human3.13201838
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.12211283
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.11964241
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.11964241
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.11964241
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09547395
15FOXM1_23109430_ChIP-Seq_U2OS_Human3.03223400
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.97348360
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.95979357
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.88603063
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.86432005
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85053508
21GBX2_23144817_ChIP-Seq_PC3_Human2.71784568
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.70211636
23XRN2_22483619_ChIP-Seq_HELA_Human2.64639974
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59995417
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57550318
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.40403734
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39545936
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39492327
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.33770248
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33055467
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30905070
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.21873659
33IGF1R_20145208_ChIP-Seq_DFB_Human2.20570049
34EWS_26573619_Chip-Seq_HEK293_Human2.20186029
35NANOG_18555785_ChIP-Seq_MESCs_Mouse2.18343942
36POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17281342
37TP63_19390658_ChIP-ChIP_HaCaT_Human2.17234060
38AR_21909140_ChIP-Seq_LNCAP_Human2.10745430
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09720756
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.09573691
41SRY_22984422_ChIP-ChIP_TESTIS_Rat2.07675170
42E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03830219
43NOTCH1_21737748_ChIP-Seq_TLL_Human2.03640272
44CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01090424
45P300_19829295_ChIP-Seq_ESCs_Human1.99722581
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96744085
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94603731
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.93549102
49KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.91700115
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89687420
51FUS_26573619_Chip-Seq_HEK293_Human1.88357490
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88008398
53TTF2_22483619_ChIP-Seq_HELA_Human1.87714592
54IRF1_19129219_ChIP-ChIP_H3396_Human1.86115170
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.83560200
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81732637
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.78855103
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78644900
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77512374
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74306122
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.73179441
62TAF15_26573619_Chip-Seq_HEK293_Human1.73029739
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71568650
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69886756
65VDR_23849224_ChIP-Seq_CD4+_Human1.69730133
66MYC_18940864_ChIP-ChIP_HL60_Human1.66635369
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.66036157
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65781489
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.61666624
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60084698
71ER_23166858_ChIP-Seq_MCF-7_Human1.59898488
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58739822
73BCAT_22108803_ChIP-Seq_LS180_Human1.58368341
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57132167
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56922008
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56723865
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56555150
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56111076
79CBP_20019798_ChIP-Seq_JUKART_Human1.56111076
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53954643
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52732755
82TP53_22573176_ChIP-Seq_HFKS_Human1.52313033
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.52237221
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51697553
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.50791862
86GABP_19822575_ChIP-Seq_HepG2_Human1.47717762
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47083311
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45843666
89FOXP3_21729870_ChIP-Seq_TREG_Human1.45258850
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45026403
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42438123
92DCP1A_22483619_ChIP-Seq_HELA_Human1.41606449
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39722078
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39654517
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39316961
96SOX2_19829295_ChIP-Seq_ESCs_Human1.39258130
97NANOG_19829295_ChIP-Seq_ESCs_Human1.39258130
98SMAD4_21741376_ChIP-Seq_EPCs_Human1.38374563
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.38157046
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37426418
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35358208
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34730642
103OCT4_18692474_ChIP-Seq_MEFs_Mouse1.34669124
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34202469
105AR_25329375_ChIP-Seq_VCAP_Human1.34090244
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33901250
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.33901250
108NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33304556
109SMAD4_21799915_ChIP-Seq_A2780_Human1.33125421
110* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32731909
111NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32338124
112RNF2_27304074_Chip-Seq_NSC_Mouse1.31733456
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.31454025
114* TCF4_23295773_ChIP-Seq_U87_Human1.30264689
115* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29323104
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28705280
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28683621
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28525667
119STAT3_23295773_ChIP-Seq_U87_Human1.28472121
120CBX2_27304074_Chip-Seq_ESCs_Mouse1.27956761
121* EZH2_27294783_Chip-Seq_NPCs_Mouse1.26179606
122SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25272422
123TCF4_22108803_ChIP-Seq_LS180_Human1.24558318
124PIAS1_25552417_ChIP-Seq_VCAP_Human1.23887758
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23062309
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22957759
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22758081
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22758081
129AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21784170
130MYC_22102868_ChIP-Seq_BL_Human1.20535902
131KDM5A_27292631_Chip-Seq_BREAST_Human1.20300634
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19924516
133SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19651056
134FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19329283
135POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18593172
136NCOR_22424771_ChIP-Seq_293T_Human1.18421907
137* RUNX2_22187159_ChIP-Seq_PCA_Human1.17424737
138AR_20517297_ChIP-Seq_VCAP_Human1.16920638
139SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16769722
140NANOG_21062744_ChIP-ChIP_HESCs_Human1.16398004
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16088137
142* PRDM14_20953172_ChIP-Seq_ESCs_Human1.15875786
143ELK1_19687146_ChIP-ChIP_HELA_Human1.14740168
144SOX2_16153702_ChIP-ChIP_HESCs_Human1.13829342
145ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12805920
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12584853
147PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09937726
148* EED_16625203_ChIP-ChIP_MESCs_Mouse1.09933403
149ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09927150
150FLI1_21867929_ChIP-Seq_TH2_Mouse1.09689896
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09211577
152STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09106075
153GATA3_21878914_ChIP-Seq_MCF-7_Human1.08180758
154CIITA_25753668_ChIP-Seq_RAJI_Human1.06856772
155YY1_21170310_ChIP-Seq_MESCs_Mouse1.06681239
156NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05877808
157HOXB7_26014856_ChIP-Seq_BT474_Human1.05512463
158ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05437395
159CDX2_22108803_ChIP-Seq_LS180_Human1.05297774
160DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04666486
161FOXH1_21741376_ChIP-Seq_EPCs_Human1.04609289
162* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04455469
163* EZH2_27304074_Chip-Seq_ESCs_Mouse1.03084226
164* SMAD3_21741376_ChIP-Seq_HESCs_Human1.02338486
165SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02107142
166REST_21632747_ChIP-Seq_MESCs_Mouse1.01552639
167* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00690168
168* CRX_20693478_ChIP-Seq_RETINA_Mouse1.00507121
169TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00160641
170TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99956806
171PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99083270
172NANOG_20526341_ChIP-Seq_ESCs_Human0.97390383
173* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96947925
174* EOMES_21245162_ChIP-Seq_HESCs_Human0.96288729
175* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95333644
176NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95257191
177CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94257064
178YY1_22570637_ChIP-Seq_MALME-3M_Human0.93346700
179NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93022225
180KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92265901
181CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91881740
182POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91828058
183CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89006207
184ELK1_22589737_ChIP-Seq_MCF10A_Human0.88194345
185TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86656617
186MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85825292
187FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.83277469
188POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.82431829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry8.95064990
2MP0002234_abnormal_pharynx_morphology4.70705454
3MP0004133_heterotaxia4.26934635
4MP0008932_abnormal_embryonic_tissue3.61310749
5MP0000678_abnormal_parathyroid_gland3.31545412
6MP0003195_calcinosis3.18022008
7* MP0003119_abnormal_digestive_system3.15128106
8MP0004957_abnormal_blastocyst_morpholog3.08657372
9MP0003693_abnormal_embryo_hatching3.08216254
10MP0003283_abnormal_digestive_organ2.94112129
11MP0010030_abnormal_orbit_morphology2.89430968
12MP0005646_abnormal_pituitary_gland2.84993931
13MP0003123_paternal_imprinting2.71387869
14MP0003937_abnormal_limbs/digits/tail_de2.54339096
15MP0003077_abnormal_cell_cycle2.47846545
16MP0002160_abnormal_reproductive_system2.47794334
17MP0002837_dystrophic_cardiac_calcinosis2.40430495
18MP0002653_abnormal_ependyma_morphology2.39310508
19* MP0002084_abnormal_developmental_patter2.22940354
20MP0000462_abnormal_digestive_system2.22323975
21MP0001730_embryonic_growth_arrest2.20125760
22MP0005551_abnormal_eye_electrophysiolog2.17732764
23MP0003646_muscle_fatigue2.17687562
24MP0000428_abnormal_craniofacial_morphol2.14289621
25MP0002736_abnormal_nociception_after2.11983149
26MP0001968_abnormal_touch/_nociception2.10296448
27MP0003942_abnormal_urinary_system2.06786562
28MP0008872_abnormal_physiological_respon2.05411263
29MP0004885_abnormal_endolymph2.03900346
30MP0002138_abnormal_hepatobiliary_system2.03314906
31MP0002127_abnormal_cardiovascular_syste1.97693529
32MP0005360_urolithiasis1.94433199
33* MP0005380_embryogenesis_phenotype1.93908461
34* MP0001672_abnormal_embryogenesis/_devel1.93908461
35MP0003385_abnormal_body_wall1.93075502
36MP0002111_abnormal_tail_morphology1.91857069
37MP0010094_abnormal_chromosome_stability1.83800341
38MP0000049_abnormal_middle_ear1.77222544
39MP0003111_abnormal_nucleus_morphology1.73122837
40MP0008057_abnormal_DNA_replication1.73105760
41MP0000631_abnormal_neuroendocrine_gland1.71459174
42MP0001697_abnormal_embryo_size1.71139536
43* MP0002085_abnormal_embryonic_tissue1.66656060
44MP0005499_abnormal_olfactory_system1.65132284
45MP0005394_taste/olfaction_phenotype1.65132284
46MP0002163_abnormal_gland_morphology1.62653460
47MP0002876_abnormal_thyroid_physiology1.61200911
48MP0004145_abnormal_muscle_electrophysio1.60768078
49MP0003984_embryonic_growth_retardation1.58257515
50MP0002088_abnormal_embryonic_growth/wei1.56605271
51MP0003935_abnormal_craniofacial_develop1.56422208
52MP0005253_abnormal_eye_physiology1.54706701
53MP0003787_abnormal_imprinting1.52009227
54MP0002177_abnormal_outer_ear1.48735999
55MP0000372_irregular_coat_pigmentation1.48298627
56MP0000350_abnormal_cell_proliferation1.47588327
57MP0001986_abnormal_taste_sensitivity1.43226788
58MP0003011_delayed_dark_adaptation1.40671905
59MP0008875_abnormal_xenobiotic_pharmacok1.39294998
60MP0004142_abnormal_muscle_tone1.39186129
61MP0002272_abnormal_nervous_system1.37918611
62MP0000432_abnormal_head_morphology1.36768402
63MP0005645_abnormal_hypothalamus_physiol1.36738880
64MP0000762_abnormal_tongue_morphology1.35438169
65MP0003315_abnormal_perineum_morphology1.34644423
66MP0005389_reproductive_system_phenotype1.33602142
67MP0001984_abnormal_olfaction1.32942492
68MP0004197_abnormal_fetal_growth/weight/1.31498846
69MP0001919_abnormal_reproductive_system1.29803445
70MP0009053_abnormal_anal_canal1.29207205
71MP0006072_abnormal_retinal_apoptosis1.27211823
72MP0000534_abnormal_ureter_morphology1.26895724
73* MP0002080_prenatal_lethality1.26366543
74MP0008007_abnormal_cellular_replicative1.26126037
75MP0008789_abnormal_olfactory_epithelium1.25450679
76MP0008877_abnormal_DNA_methylation1.25232799
77MP0009745_abnormal_behavioral_response1.23296956
78* MP0002086_abnormal_extraembryonic_tissu1.22033238
79MP0005671_abnormal_response_to1.21331440
80MP0003880_abnormal_central_pattern1.20268839
81MP0005084_abnormal_gallbladder_morpholo1.19125125
82MP0006276_abnormal_autonomic_nervous1.19004193
83MP0000538_abnormal_urinary_bladder1.18209509
84MP0002638_abnormal_pupillary_reflex1.16773169
85MP0003566_abnormal_cell_adhesion1.16494171
86MP0002938_white_spotting1.13592735
87MP0004742_abnormal_vestibular_system1.13570800
88MP0000537_abnormal_urethra_morphology1.12073557
89MP0005379_endocrine/exocrine_gland_phen1.11785159
90* MP0003861_abnormal_nervous_system1.08727531
91MP0005410_abnormal_fertilization1.08520417
92MP0003718_maternal_effect1.06329733
93MP0002932_abnormal_joint_morphology1.06148410
94MP0008058_abnormal_DNA_repair1.05798508
95MP0003936_abnormal_reproductive_system1.05205840
96MP0000427_abnormal_hair_cycle1.04233037
97MP0003806_abnormal_nucleotide_metabolis1.04165464
98MP0006292_abnormal_olfactory_placode1.02606385
99MP0008775_abnormal_heart_ventricle1.01480873
100MP0004147_increased_porphyrin_level1.01015812
101MP0008995_early_reproductive_senescence0.99613169
102MP0001486_abnormal_startle_reflex0.98635705
103MP0002735_abnormal_chemical_nociception0.97800490
104MP0001963_abnormal_hearing_physiology0.97726527
105MP0000383_abnormal_hair_follicle0.97373054
106MP0001529_abnormal_vocalization0.95980229
107MP0002210_abnormal_sex_determination0.95157781
108MP0001501_abnormal_sleep_pattern0.94632402
109MP0001929_abnormal_gametogenesis0.93975482
110MP0001293_anophthalmia0.93518144
111MP0004215_abnormal_myocardial_fiber0.92927260
112MP0002102_abnormal_ear_morphology0.92660526
113MP0004043_abnormal_pH_regulation0.90668288
114MP0003136_yellow_coat_color0.90216837
115* MP0002925_abnormal_cardiovascular_devel0.89965136
116MP0005195_abnormal_posterior_eye0.89171260
117MP0003121_genomic_imprinting0.87699985
118MP0003567_abnormal_fetal_cardiomyocyte0.87561661
119MP0003632_abnormal_nervous_system0.87489479
120MP0000653_abnormal_sex_gland0.87223758
121MP0000026_abnormal_inner_ear0.86087015
122MP0001119_abnormal_female_reproductive0.85182883
123MP0002557_abnormal_social/conspecific_i0.84576041
124MP0009046_muscle_twitch0.83700697
125MP0005075_abnormal_melanosome_morpholog0.81195052
126MP0002098_abnormal_vibrissa_morphology0.78893974
127MP0009697_abnormal_copulation0.78690094
128MP0002332_abnormal_exercise_endurance0.78096147
129MP0001145_abnormal_male_reproductive0.77916108
130MP0001727_abnormal_embryo_implantation0.77450576
131MP0003137_abnormal_impulse_conducting0.77329632
132MP0003786_premature_aging0.76244288
133MP0002751_abnormal_autonomic_nervous0.75350683
134MP0002752_abnormal_somatic_nervous0.75167219
135MP0003698_abnormal_male_reproductive0.73816670
136MP0005174_abnormal_tail_pigmentation0.72843746
137MP0002233_abnormal_nose_morphology0.72416821
138MP0002116_abnormal_craniofacial_bone0.72362977
139MP0002572_abnormal_emotion/affect_behav0.72301028
140MP0002734_abnormal_mechanical_nocicepti0.71533335
141MP0003938_abnormal_ear_development0.70722967
142MP0003252_abnormal_bile_duct0.70603718
143MP0005670_abnormal_white_adipose0.70572857
144MP0005332_abnormal_amino_acid0.70139969
145MP0005647_abnormal_sex_gland0.69663929
146MP0002733_abnormal_thermal_nociception0.68670081
147MP0005085_abnormal_gallbladder_physiolo0.67754727
148MP0000516_abnormal_urinary_system0.67105229
149MP0005367_renal/urinary_system_phenotyp0.67105229
150MP0009672_abnormal_birth_weight0.66129347
151MP0002928_abnormal_bile_duct0.65394752
152MP0002249_abnormal_larynx_morphology0.62577629
153MP0000767_abnormal_smooth_muscle0.61537748
154* MP0000266_abnormal_heart_morphology0.61157009
155MP0000313_abnormal_cell_death0.60237751
156MP0005248_abnormal_Harderian_gland0.58970506
157MP0001286_abnormal_eye_development0.58691207
158MP0003755_abnormal_palate_morphology0.53779240
159MP0002114_abnormal_axial_skeleton0.53664927
160MP0001485_abnormal_pinna_reflex0.53577186
161MP0005384_cellular_phenotype0.52794961
162MP0002254_reproductive_system_inflammat0.52399642
163MP0000163_abnormal_cartilage_morphology0.50767949
164MP0000358_abnormal_cell_content/0.50737804
165MP0005266_abnormal_metabolism0.47635147
166MP0003221_abnormal_cardiomyocyte_apopto0.45940000
167MP0010352_gastrointestinal_tract_polyps0.45873643
168MP0001340_abnormal_eyelid_morphology0.44585205
169MP0002081_perinatal_lethality0.44432227
170MP0001614_abnormal_blood_vessel0.44189802
171MP0000750_abnormal_muscle_regeneration0.44035211
172MP0002277_abnormal_respiratory_mucosa0.40810997
173MP0005621_abnormal_cell_physiology0.40401828

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)6.46672369
2Abnormality of abdominal situs (HP:0011620)6.34868783
3Abdominal situs inversus (HP:0003363)6.34868783
4Shawl scrotum (HP:0000049)6.00566956
5Breast aplasia (HP:0100783)5.10447169
6Abnormality of endocrine pancreas physiology (HP:0012093)4.74147928
7Abnormality of the pancreatic islet cells (HP:0006476)4.74147928
8Late onset (HP:0003584)4.73306344
9Aplasia/Hypoplasia of the breasts (HP:0010311)4.63044458
10Rib fusion (HP:0000902)4.35913190
11Aplasia/hypoplasia of the humerus (HP:0006507)4.22904341
12Anosmia (HP:0000458)4.08082259
13Double outlet right ventricle (HP:0001719)4.03789129
14Congenital malformation of the right heart (HP:0011723)4.03789129
15Birth length less than 3rd percentile (HP:0003561)3.94359080
16Absent radius (HP:0003974)3.78502916
17Short humerus (HP:0005792)3.73460618
18Pancreatic cysts (HP:0001737)3.68666905
19Supernumerary spleens (HP:0009799)3.67251681
20Breast hypoplasia (HP:0003187)3.59721910
21Absent forearm bone (HP:0003953)3.56511741
22Aplasia involving forearm bones (HP:0009822)3.56511741
23Carpal bone hypoplasia (HP:0001498)3.52091868
24Congenital stationary night blindness (HP:0007642)3.51958523
25Abnormality of the anterior horn cell (HP:0006802)3.34182048
26Degeneration of anterior horn cells (HP:0002398)3.34182048
27Abnormal umbilical cord blood vessels (HP:0011403)3.29625621
28Single umbilical artery (HP:0001195)3.29625621
29Abnormality of the fetal cardiovascular system (HP:0010948)3.29625621
30Abnormality of the renal cortex (HP:0011035)3.23599591
31Pancreatic fibrosis (HP:0100732)3.14477610
32Molar tooth sign on MRI (HP:0002419)3.14212604
33Abnormality of midbrain morphology (HP:0002418)3.14212604
34Hypoplasia of the fovea (HP:0007750)3.12728519
35Aplasia/Hypoplasia of the fovea (HP:0008060)3.12728519
36Nephronophthisis (HP:0000090)3.08361937
37Erectile abnormalities (HP:0100639)3.07044396
38Renal cortical cysts (HP:0000803)3.06969752
39Ketoacidosis (HP:0001993)2.97307858
40Methylmalonic acidemia (HP:0002912)2.95161125
41Abnormal ventriculo-arterial connection (HP:0011563)2.94083966
42Transposition of the great arteries (HP:0001669)2.94083966
43Abnormal connection of the cardiac segments (HP:0011545)2.94083966
44Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.91328528
45Hypogonadotrophic hypogonadism (HP:0000044)2.90609256
46True hermaphroditism (HP:0010459)2.86749297
47Cerebral hypomyelination (HP:0006808)2.85595271
48Asplenia (HP:0001746)2.81559934
49Abolished electroretinogram (ERG) (HP:0000550)2.78786455
50Back pain (HP:0003418)2.78200364
51Stenosis of the external auditory canal (HP:0000402)2.70513889
52Abnormality of the phalanges of the 5th finger (HP:0004213)2.69648876
53Pendular nystagmus (HP:0012043)2.68653765
54Abnormality of the umbilical cord (HP:0010881)2.68222338
55Abnormality of the renal medulla (HP:0100957)2.66702213
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.64689102
57Congenital, generalized hypertrichosis (HP:0004540)2.62658738
58Abnormality of the fovea (HP:0000493)2.61817196
59Short tibia (HP:0005736)2.61483527
60Proximal placement of thumb (HP:0009623)2.59112255
61Trismus (HP:0000211)2.57386766
62Deviation of the thumb (HP:0009603)2.57101293
63Anal stenosis (HP:0002025)2.56323868
64Colon cancer (HP:0003003)2.54402436
65Hemivertebrae (HP:0002937)2.53470782
66Preauricular skin tag (HP:0000384)2.52738338
67Aplasia/Hypoplasia of the spleen (HP:0010451)2.52373903
68Selective tooth agenesis (HP:0001592)2.52229996
69Patellar aplasia (HP:0006443)2.50292048
70Attenuation of retinal blood vessels (HP:0007843)2.47597100
71Vertebral fusion (HP:0002948)2.46519403
72IgG deficiency (HP:0004315)2.44114056
73Oral leukoplakia (HP:0002745)2.43881378
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.43673850
75Fused cervical vertebrae (HP:0002949)2.42573840
76Methylmalonic aciduria (HP:0012120)2.41832714
77Bilateral microphthalmos (HP:0007633)2.41517497
78Macrocytic anemia (HP:0001972)2.37317549
79Atrophy/Degeneration involving motor neurons (HP:0007373)2.35939958
80Multifactorial inheritance (HP:0001426)2.33299409
81Spinal muscular atrophy (HP:0007269)2.32979464
82Sprengel anomaly (HP:0000912)2.32763324
83Long eyelashes (HP:0000527)2.32674776
84Reticulocytopenia (HP:0001896)2.32544027
85Aplasia/Hypoplasia involving the musculature (HP:0001460)2.31507616
86Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.29610460
87Aplasia/Hypoplasia of the patella (HP:0006498)2.29133429
883-Methylglutaconic aciduria (HP:0003535)2.19215546
89Increased serum pyruvate (HP:0003542)2.17244423
90Abnormality of glycolysis (HP:0004366)2.17244423
91Progressive inability to walk (HP:0002505)2.17179904
9211 pairs of ribs (HP:0000878)2.16931639
93Abnormality of the middle phalanges of the toes (HP:0010183)2.16547059
94Abnormal rod and cone electroretinograms (HP:0008323)2.16426720
95Skin tags (HP:0010609)2.15462990
96Long palpebral fissure (HP:0000637)2.14174831
97Type II lissencephaly (HP:0007260)2.13804353
98Abnormal biliary tract physiology (HP:0012439)2.12215617
99Bile duct proliferation (HP:0001408)2.12215617
100Abnormality of alanine metabolism (HP:0010916)2.11552134
101Hyperalaninemia (HP:0003348)2.11552134
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11552134
103Decreased central vision (HP:0007663)2.10845680
104Rough bone trabeculation (HP:0100670)2.10689740
105Aplasia/hypoplasia of the uterus (HP:0008684)2.10025376
106Septo-optic dysplasia (HP:0100842)2.08685788
107Aplasia/Hypoplasia of the hallux (HP:0008362)2.08512003
108Medial flaring of the eyebrow (HP:0010747)2.07771570
109Short hallux (HP:0010109)2.06970179
110Aplasia/Hypoplasia of the uvula (HP:0010293)2.06799829
111Cystic liver disease (HP:0006706)2.04211002
112Rectovaginal fistula (HP:0000143)2.03411110
113Rectal fistula (HP:0100590)2.03411110
114Rocker bottom foot (HP:0001838)2.03078346
115Glossoptosis (HP:0000162)2.01606264
116Sclerocornea (HP:0000647)2.01230604
117Hypoplasia of the uterus (HP:0000013)2.00716708
118Insulin resistance (HP:0000855)1.98866960
119Abnormality of the proximal phalanges of the hand (HP:0009834)1.98734391
120Stomach cancer (HP:0012126)1.98005444
121Optic nerve hypoplasia (HP:0000609)1.97122655
122Abnormality of the nasal septum (HP:0000419)1.96250891
123Chorioretinal atrophy (HP:0000533)1.95847688
124Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.94340794
125Short 1st metacarpal (HP:0010034)1.94340794
126Acute necrotizing encephalopathy (HP:0006965)1.94164179
127Absent/shortened dynein arms (HP:0200106)1.93514319
128Dynein arm defect of respiratory motile cilia (HP:0012255)1.93514319
129Impulsivity (HP:0100710)1.93427088
130Atresia of the external auditory canal (HP:0000413)1.93264427
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.92400651
132Hypoplasia of the radius (HP:0002984)1.91821125
133Tubular atrophy (HP:0000092)1.91715834
134Abnormality of the ileum (HP:0001549)1.91556112
135Bony spicule pigmentary retinopathy (HP:0007737)1.91368953
136Hyperglycinemia (HP:0002154)1.91097874
137Hypoplastic pelvis (HP:0008839)1.89568656
138Anal atresia (HP:0002023)1.89105347
139Increased corneal curvature (HP:0100692)1.89078092
140Keratoconus (HP:0000563)1.89078092
141Vaginal fistula (HP:0004320)1.88252324
142Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.87436094
143Congenital sensorineural hearing impairment (HP:0008527)1.87386230
144Meckel diverticulum (HP:0002245)1.87082556
145Abnormality of the labia minora (HP:0012880)1.87015510
146Intestinal atresia (HP:0011100)1.86551773
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85853142
148Enlarged kidneys (HP:0000105)1.85678085
149Inability to walk (HP:0002540)1.84159581
150Broad toe (HP:0001837)1.83503018
151Progressive external ophthalmoplegia (HP:0000590)1.83030859
152Truncus arteriosus (HP:0001660)1.82797261
153Gaze-evoked nystagmus (HP:0000640)1.81494715
154Symphalangism affecting the phalanges of the hand (HP:0009773)1.80887132
155Increased CSF lactate (HP:0002490)1.80055474
156Abnormal number of incisors (HP:0011064)1.79290905
157Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78855898
158Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.78802791
159Abnormality of vitamin B metabolism (HP:0004340)1.78176683
160Aplasia/Hypoplasia of the macula (HP:0008059)1.77617054
161Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77512056
162Low posterior hairline (HP:0002162)1.77257326
163Fibular aplasia (HP:0002990)1.77074559
164Abnormality of cells of the erythroid lineage (HP:0012130)1.76394496
165Thyroiditis (HP:0100646)1.76191414
166CNS hypomyelination (HP:0003429)1.76104538
167Intestinal fistula (HP:0100819)1.76024525
168Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.75972418
169Mitochondrial inheritance (HP:0001427)1.75972025
170Polydipsia (HP:0001959)1.75892904
171Abnormal drinking behavior (HP:0030082)1.75892904
172Missing ribs (HP:0000921)1.75526239
173Decreased circulating renin level (HP:0003351)1.75358378
174Abnormal lung lobation (HP:0002101)1.74483143
175Multiple enchondromatosis (HP:0005701)1.74390022
176Postaxial foot polydactyly (HP:0001830)1.74288475
177Progressive macrocephaly (HP:0004481)1.74255487
178Primary amenorrhea (HP:0000786)1.73942896
179Horseshoe kidney (HP:0000085)1.73353657
180Acute encephalopathy (HP:0006846)1.73195384
181Anencephaly (HP:0002323)1.72728872
182Oligohydramnios (HP:0001562)1.72493011
183Absent thumb (HP:0009777)1.72439358
184Carpal synostosis (HP:0009702)1.72413987
185Abnormality of the renal collecting system (HP:0004742)1.71093620
186Partial duplication of the phalanx of hand (HP:0009999)1.70722418
187Abnormality of the humerus (HP:0003063)1.69771525
188Preauricular pit (HP:0004467)1.69708339
189Periauricular skin pits (HP:0100277)1.69708339
190Postnatal microcephaly (HP:0005484)1.68700117
191Preaxial foot polydactyly (HP:0001841)1.66728035

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS29.59635623
2BUB14.38095533
3FRK3.90288339
4MAP4K23.01296670
5TESK22.90377230
6NUAK12.89687335
7TXK2.85901690
8WEE12.84945856
9GRK12.83005712
10TAOK32.78359907
11PLK42.77327764
12CDC72.73665815
13ADRBK22.73135341
14WNK32.49427039
15TSSK62.42132636
16EIF2AK12.41198954
17PASK2.35573372
18WNK42.18516862
19PRKD32.17509572
20TGFBR11.95050147
21PINK11.93602158
22SRPK11.83077984
23VRK11.80069580
24KDR1.74988910
25NEK11.74682232
26PAK41.73814439
27TRIM281.73802637
28MST41.73557683
29MAPK131.64258645
30MKNK11.60528699
31PLK31.59396756
32TESK11.55893917
33STK391.55828092
34TTK1.54319333
35INSRR1.48977690
36PLK11.43472894
37OXSR11.39643476
38MAP3K41.38961500
39MAP3K81.38875005
40BCKDK1.37933341
41DYRK31.37147745
42EPHA21.33567078
43TLK11.22517227
44LIMK11.19377683
45AKT31.19170222
46TNIK1.18790510
47TIE11.14862598
48VRK21.14301667
49ZAK1.10575713
50ALK1.09662482
51AURKB1.07033350
52PAK11.05233696
53CASK1.04382301
54CDK71.04231616
55STK161.01000083
56DYRK20.99439668
57AURKA0.97852143
58CSNK1G20.93167861
59CSNK1G10.92506122
60ERN10.91741461
61NME10.90605907
62NEK20.90349638
63TAF10.89659946
64MAP2K20.87615572
65ADRBK10.87464439
66MKNK20.84686261
67STK100.84325991
68CHEK10.84165828
69MAP3K110.83541555
70GRK60.81708677
71FLT30.80109161
72ATR0.79613825
73MAPKAPK30.79140914
74MUSK0.76708025
75IKBKB0.73798154
76EIF2AK30.73548041
77PRKCG0.72831340
78RPS6KA40.71742585
79TEC0.71362146
80PRKCE0.70431804
81MAP3K30.68858179
82CSNK1E0.68793344
83CDK120.66975820
84PRKCQ0.64470366
85STK30.62587426
86BRSK20.61982771
87BRD40.61323196
88BRSK10.60659520
89BCR0.60472291
90PRKCI0.57946531
91PIK3CA0.57706806
92BRAF0.56199824
93PLK20.55814930
94CDK20.55800681
95PHKG20.54645959
96PHKG10.54645959
97ITK0.54639516
98MAP2K70.54132715
99CSNK2A10.53940530
100CSNK1A1L0.53892081
101MAPKAPK50.53590712
102RPS6KA50.53568625
103ERBB40.53397471
104PIM20.53027798
105NTRK20.52855588
106MARK10.52591781
107CSNK2A20.51504468
108STK38L0.50326441
109ERBB30.50012218
110CHEK20.49801285
111GRK50.49776890
112GRK70.49072861
113PAK30.49050090
114MAP2K60.48391329
115KSR20.47169370
116CAMK2A0.46328280
117TTN0.46286970
118IGF1R0.46187308
119DYRK1B0.45478457
120PRKD10.45208683
121EPHA40.43771243
122PRKACA0.43672416
123KIT0.43374578
124CCNB10.43040972
125FGFR10.42145389
126CSNK1A10.41638779
127ATM0.40984178
128MAP2K10.39694493
129CSNK1D0.39081769
130CDK10.38998462
131DAPK20.38512472
132EIF2AK20.37601223
133CDK140.36405335
134PRKCA0.36225846
135FGFR20.35716563
136TNK20.35328469
137ERBB20.34792123
138AKT20.33958716
139ABL20.33114222
140NME20.32404546
141NLK0.31936831
142RAF10.31872230
143CDK60.31652735
144SCYL20.31339863
145ACVR1B0.31305630
146PRKG10.30867404
147MATK0.30698621
148PNCK0.30601021
149MAP3K90.28254626
150MTOR0.28178345
151DAPK10.28054430
152LRRK20.27303553
153STK40.26331823
154CDK11A0.25031767
155CDK150.24129020
156CSNK1G30.23434245
157PTK20.23023314
158RPS6KB20.22639061
159CDK40.22043899
160MAPK90.22032110
161CDK80.21037718
162CDK180.21036618
163CDK190.20578544
164BMPR1B0.19036424
165PRKD20.18494834
166PRKDC0.17463868

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.20319437
2DNA replication_Homo sapiens_hsa030303.98176222
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.84280630
4One carbon pool by folate_Homo sapiens_hsa006703.78928923
5Spliceosome_Homo sapiens_hsa030403.65999393
6Proteasome_Homo sapiens_hsa030503.59828625
7Ribosome_Homo sapiens_hsa030103.53527126
8Mismatch repair_Homo sapiens_hsa034303.24963146
9RNA transport_Homo sapiens_hsa030133.06845331
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.00166122
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.77811172
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.74423629
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.68741419
14Phototransduction_Homo sapiens_hsa047442.66129210
15Pyrimidine metabolism_Homo sapiens_hsa002402.37301438
16Vitamin B6 metabolism_Homo sapiens_hsa007502.36745599
17Base excision repair_Homo sapiens_hsa034102.16801787
18Cell cycle_Homo sapiens_hsa041102.13812417
19Caffeine metabolism_Homo sapiens_hsa002322.11405589
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99749240
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99005123
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93990157
23Linoleic acid metabolism_Homo sapiens_hsa005911.93273616
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89379745
25Biosynthesis of amino acids_Homo sapiens_hsa012301.85973736
26Nicotine addiction_Homo sapiens_hsa050331.80367893
27Retinol metabolism_Homo sapiens_hsa008301.79675826
28Nucleotide excision repair_Homo sapiens_hsa034201.78505265
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75600140
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75447044
31Nitrogen metabolism_Homo sapiens_hsa009101.74649265
32Melanoma_Homo sapiens_hsa052181.74289361
33Basal cell carcinoma_Homo sapiens_hsa052171.60695650
34Sulfur metabolism_Homo sapiens_hsa009201.60133035
35Butanoate metabolism_Homo sapiens_hsa006501.59834162
36Olfactory transduction_Homo sapiens_hsa047401.57352734
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53558936
38Tryptophan metabolism_Homo sapiens_hsa003801.48617489
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44899456
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.44111420
41p53 signaling pathway_Homo sapiens_hsa041151.43989221
42Hedgehog signaling pathway_Homo sapiens_hsa043401.40225767
43Homologous recombination_Homo sapiens_hsa034401.36929369
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36870037
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.35998682
46Chemical carcinogenesis_Homo sapiens_hsa052041.32944689
47Propanoate metabolism_Homo sapiens_hsa006401.32744729
48Primary immunodeficiency_Homo sapiens_hsa053401.28920064
49Hippo signaling pathway_Homo sapiens_hsa043901.27366806
50RNA degradation_Homo sapiens_hsa030181.26187062
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25338369
52mRNA surveillance pathway_Homo sapiens_hsa030151.23074604
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.22216214
54Oocyte meiosis_Homo sapiens_hsa041141.21714767
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21210907
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20839042
57Ether lipid metabolism_Homo sapiens_hsa005651.15845873
58Purine metabolism_Homo sapiens_hsa002301.14608097
59Morphine addiction_Homo sapiens_hsa050321.14110239
60Steroid biosynthesis_Homo sapiens_hsa001001.13666158
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10311046
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.10079291
63Folate biosynthesis_Homo sapiens_hsa007901.08864791
64Selenocompound metabolism_Homo sapiens_hsa004501.08603095
65Carbon metabolism_Homo sapiens_hsa012001.07440579
66Taste transduction_Homo sapiens_hsa047421.04686502
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01168229
68Asthma_Homo sapiens_hsa053101.00851346
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97181459
70Peroxisome_Homo sapiens_hsa041460.96053817
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93871388
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93791445
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93301050
74Basal transcription factors_Homo sapiens_hsa030220.93216783
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.91919441
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90711681
77Epstein-Barr virus infection_Homo sapiens_hsa051690.85436791
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.85368726
79GABAergic synapse_Homo sapiens_hsa047270.83768965
80Non-homologous end-joining_Homo sapiens_hsa034500.83255926
81Arachidonic acid metabolism_Homo sapiens_hsa005900.81788225
82Serotonergic synapse_Homo sapiens_hsa047260.78965333
83TGF-beta signaling pathway_Homo sapiens_hsa043500.77605605
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76787401
85Glycerolipid metabolism_Homo sapiens_hsa005610.76073216
86Wnt signaling pathway_Homo sapiens_hsa043100.75787208
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75432606
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74294070
89Ovarian steroidogenesis_Homo sapiens_hsa049130.73478465
90Fanconi anemia pathway_Homo sapiens_hsa034600.71410547
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71320997
92Circadian entrainment_Homo sapiens_hsa047130.71271363
93MicroRNAs in cancer_Homo sapiens_hsa052060.70949008
94Type I diabetes mellitus_Homo sapiens_hsa049400.69233941
95Thyroid cancer_Homo sapiens_hsa052160.69129953
96Systemic lupus erythematosus_Homo sapiens_hsa053220.68782560
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68045259
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67829361
99Autoimmune thyroid disease_Homo sapiens_hsa053200.66902360
100ABC transporters_Homo sapiens_hsa020100.66227170
101Graft-versus-host disease_Homo sapiens_hsa053320.64767602
102Adherens junction_Homo sapiens_hsa045200.64647808
103Collecting duct acid secretion_Homo sapiens_hsa049660.63413301
104Huntingtons disease_Homo sapiens_hsa050160.62720442
105Insulin secretion_Homo sapiens_hsa049110.62660220
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62110306
107Phenylalanine metabolism_Homo sapiens_hsa003600.61977411
108Vitamin digestion and absorption_Homo sapiens_hsa049770.61220731
109Allograft rejection_Homo sapiens_hsa053300.60832128
110HTLV-I infection_Homo sapiens_hsa051660.60590809
111Fatty acid elongation_Homo sapiens_hsa000620.59676854
112Pentose phosphate pathway_Homo sapiens_hsa000300.58854835
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54934398
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54593801
115Rap1 signaling pathway_Homo sapiens_hsa040150.53734111
116Regulation of autophagy_Homo sapiens_hsa041400.52889109
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52708237
118Melanogenesis_Homo sapiens_hsa049160.50384619
119Histidine metabolism_Homo sapiens_hsa003400.49190517
120Bladder cancer_Homo sapiens_hsa052190.47000415
121Glutamatergic synapse_Homo sapiens_hsa047240.45119686
122Pathways in cancer_Homo sapiens_hsa052000.43785821
123Protein export_Homo sapiens_hsa030600.43556435
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43049620
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43046450
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41152424
127Parkinsons disease_Homo sapiens_hsa050120.40539455
128beta-Alanine metabolism_Homo sapiens_hsa004100.40294287
129Salivary secretion_Homo sapiens_hsa049700.40256512
130Viral carcinogenesis_Homo sapiens_hsa052030.40210558
131Calcium signaling pathway_Homo sapiens_hsa040200.39589069
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.39461869
133Oxidative phosphorylation_Homo sapiens_hsa001900.37314202
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36425522
135Fat digestion and absorption_Homo sapiens_hsa049750.33957830
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33130813
137Shigellosis_Homo sapiens_hsa051310.33071125
138Pyruvate metabolism_Homo sapiens_hsa006200.32689796
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32072875
140Tight junction_Homo sapiens_hsa045300.28366869
141Metabolic pathways_Homo sapiens_hsa011000.25948751
142Tyrosine metabolism_Homo sapiens_hsa003500.24385607
143Arginine and proline metabolism_Homo sapiens_hsa003300.23945830
144Prion diseases_Homo sapiens_hsa050200.21061734
145Proteoglycans in cancer_Homo sapiens_hsa052050.20498724
146Ras signaling pathway_Homo sapiens_hsa040140.20399749
147Glutathione metabolism_Homo sapiens_hsa004800.19230867
148Alcoholism_Homo sapiens_hsa050340.16539848
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16414535
150Small cell lung cancer_Homo sapiens_hsa052220.15914263
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14993774
152Arginine biosynthesis_Homo sapiens_hsa002200.09021059
153Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08749438
154Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08472546
155Axon guidance_Homo sapiens_hsa043600.07744136
156MAPK signaling pathway_Homo sapiens_hsa040100.06969279
157Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05670850
158Alzheimers disease_Homo sapiens_hsa050100.05337605
159Colorectal cancer_Homo sapiens_hsa052100.04847956
160HIF-1 signaling pathway_Homo sapiens_hsa040660.04802196
161Cardiac muscle contraction_Homo sapiens_hsa042600.01973178
162Gap junction_Homo sapiens_hsa045400.01869119

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