MKI67P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)8.35741465
2cell wall macromolecule catabolic process (GO:0016998)7.39719276
3kinetochore assembly (GO:0051382)6.97508539
4cell wall macromolecule metabolic process (GO:0044036)6.56977390
5replication fork processing (GO:0031297)5.53400178
6DNA replication checkpoint (GO:0000076)5.31259852
7meiotic chromosome segregation (GO:0045132)5.21982266
8protein localization to chromosome, centromeric region (GO:0071459)5.19985364
9mitotic chromosome condensation (GO:0007076)5.18375418
10mitotic sister chromatid segregation (GO:0000070)5.14644339
11sister chromatid segregation (GO:0000819)5.07942070
12nuclear pore complex assembly (GO:0051292)5.04731219
13mitotic metaphase plate congression (GO:0007080)5.00832470
14attachment of spindle microtubules to kinetochore (GO:0008608)4.93575905
15protein localization to kinetochore (GO:0034501)4.92221946
16resolution of meiotic recombination intermediates (GO:0000712)4.91296040
17CENP-A containing nucleosome assembly (GO:0034080)4.86940586
18metaphase plate congression (GO:0051310)4.82622626
19chromatin remodeling at centromere (GO:0031055)4.78584054
20regulation of DNA endoreduplication (GO:0032875)4.66192984
21mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.65133711
22maturation of SSU-rRNA (GO:0030490)4.64147201
23negative regulation of DNA-dependent DNA replication (GO:2000104)4.54417215
24histone exchange (GO:0043486)4.42530788
25mitotic sister chromatid cohesion (GO:0007064)4.38879348
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.38513800
27regulation of centriole replication (GO:0046599)4.36696008
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.36597586
29DNA ligation (GO:0006266)4.18856956
30protein-cofactor linkage (GO:0018065)4.16507385
31establishment of chromosome localization (GO:0051303)4.16375507
32chromosome condensation (GO:0030261)4.14370239
33mitotic G2/M transition checkpoint (GO:0044818)4.11217475
34nuclear pore organization (GO:0006999)4.06674459
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.00690146
36positive regulation of mitotic sister chromatid separation (GO:1901970)4.00690146
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.00690146
38DNA replication-independent nucleosome organization (GO:0034724)3.94618843
39DNA replication-independent nucleosome assembly (GO:0006336)3.94618843
40microtubule polymerization or depolymerization (GO:0031109)3.92043902
41centriole replication (GO:0007099)3.85945515
42regulation of nuclear cell cycle DNA replication (GO:0033262)3.80482849
43protein localization to chromosome (GO:0034502)3.77940250
44microtubule depolymerization (GO:0007019)3.76208363
45pore complex assembly (GO:0046931)3.75392541
46protein K6-linked ubiquitination (GO:0085020)3.73770736
47mitotic G2 DNA damage checkpoint (GO:0007095)3.73417186
48DNA packaging (GO:0006323)3.65997582
49positive regulation of chromosome segregation (GO:0051984)3.65966643
50chromosome segregation (GO:0007059)3.63406086
51DNA unwinding involved in DNA replication (GO:0006268)3.62436189
52regulation of spindle organization (GO:0090224)3.50846532
53negative regulation of DNA recombination (GO:0045910)3.48550368
54spindle checkpoint (GO:0031577)3.47643391
55regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.43528952
56regulation of mitotic metaphase/anaphase transition (GO:0030071)3.43528952
57synapsis (GO:0007129)3.43197105
58regulation of sister chromatid cohesion (GO:0007063)3.40195031
59regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.32843481
60DNA double-strand break processing (GO:0000729)3.29069138
61mitotic nuclear envelope disassembly (GO:0007077)3.23560755
62regulation of centrosome cycle (GO:0046605)3.18827146
63regulation of mitotic spindle organization (GO:0060236)3.17369732
64regulation of chromosome segregation (GO:0051983)3.16856033
65mitotic recombination (GO:0006312)3.16404599
66establishment of mitotic spindle localization (GO:0040001)3.12923060
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11571382
68regulation of centrosome duplication (GO:0010824)3.08774252
69DNA replication-dependent nucleosome organization (GO:0034723)3.06960738
70DNA replication-dependent nucleosome assembly (GO:0006335)3.06960738
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04779245
72mitotic spindle checkpoint (GO:0071174)3.03942037
73translesion synthesis (GO:0019985)3.02534611
74DNA catabolic process, exonucleolytic (GO:0000738)3.00635536
75ATP-dependent chromatin remodeling (GO:0043044)2.98734306
76regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94379410
77regulation of sister chromatid segregation (GO:0033045)2.93944138
78regulation of mitotic sister chromatid separation (GO:0010965)2.93944138
79regulation of mitotic sister chromatid segregation (GO:0033047)2.93944138
80positive regulation of catecholamine secretion (GO:0033605)2.92386245
81telomere maintenance via semi-conservative replication (GO:0032201)2.91053626
82DNA strand elongation involved in DNA replication (GO:0006271)2.89910576
83negative regulation of chromosome segregation (GO:0051985)2.89415502
84nuclear envelope disassembly (GO:0051081)2.89053900
85membrane disassembly (GO:0030397)2.89053900
86mesenchymal to epithelial transition (GO:0060231)2.88301451
87establishment of protein localization to mitochondrial membrane (GO:0090151)2.85600103
88negative regulation of mitotic sister chromatid separation (GO:2000816)2.85127819
89negative regulation of sister chromatid segregation (GO:0033046)2.85127819
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85127819
91negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85127819
92negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85127819
93respiratory chain complex IV assembly (GO:0008535)2.84085082
94ribosomal large subunit biogenesis (GO:0042273)2.83252516
95mitotic DNA integrity checkpoint (GO:0044774)2.82503291
96postreplication repair (GO:0006301)2.81980242
97centrosome organization (GO:0051297)2.80252914
98ventricular cardiac muscle cell development (GO:0055015)2.76648426
99spindle assembly checkpoint (GO:0071173)2.76134700
100somite development (GO:0061053)2.75751391

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.23190992
2E2F7_22180533_ChIP-Seq_HELA_Human5.70043859
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.84389534
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.30337304
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.75548614
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.69365389
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.62752291
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.59599179
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.06770935
10VDR_22108803_ChIP-Seq_LS180_Human2.94627910
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.85658395
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68576470
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.54707884
14AR_21909140_ChIP-Seq_LNCAP_Human2.46435438
15ELK1_19687146_ChIP-ChIP_HELA_Human2.40316384
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.37440286
17ZNF274_21170338_ChIP-Seq_K562_Hela2.35374561
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.14383986
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13472261
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98308845
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95977230
22FUS_26573619_Chip-Seq_HEK293_Human1.85713123
23EWS_26573619_Chip-Seq_HEK293_Human1.83787249
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.81790383
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81615720
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81044923
27MYC_18940864_ChIP-ChIP_HL60_Human1.73679542
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71047918
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67931452
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67025377
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.64232936
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58243278
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56636231
34VDR_23849224_ChIP-Seq_CD4+_Human1.56624573
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50673368
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49886100
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46619534
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42584746
39FOXP3_21729870_ChIP-Seq_TREG_Human1.41937714
40P300_19829295_ChIP-Seq_ESCs_Human1.41588992
41TAF15_26573619_Chip-Seq_HEK293_Human1.41585721
42GABP_19822575_ChIP-Seq_HepG2_Human1.35456225
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33053193
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31340428
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30088875
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28085256
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26234817
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26234817
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23217577
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.20920273
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19747533
52ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17945718
53E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15995023
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.15167516
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11881786
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11494472
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09473980
58DCP1A_22483619_ChIP-Seq_HELA_Human1.09328885
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09224084
60TTF2_22483619_ChIP-Seq_HELA_Human1.07526459
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07043838
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.05359912
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05151274
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05097339
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04296140
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02431579
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99097867
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98617295
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96701440
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96580863
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94966682
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94932140
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94078123
74PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93747770
75SMAD4_21741376_ChIP-Seq_EPCs_Human0.90908478
76E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89850956
77SOX2_19829295_ChIP-Seq_ESCs_Human0.89046463
78NANOG_19829295_ChIP-Seq_ESCs_Human0.89046463
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88934089
80BCAT_22108803_ChIP-Seq_LS180_Human0.88075095
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86681312
82EZH2_27294783_Chip-Seq_NPCs_Mouse0.86467394
83ER_23166858_ChIP-Seq_MCF-7_Human0.85729084
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84874537
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84829649
86NANOG_16153702_ChIP-ChIP_HESCs_Human0.83762213
87XRN2_22483619_ChIP-Seq_HELA_Human0.83315385
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82255249
89SRF_21415370_ChIP-Seq_HL-1_Mouse0.81449110
90THAP11_20581084_ChIP-Seq_MESCs_Mouse0.80978490
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80124078
92EZH2_22144423_ChIP-Seq_EOC_Human0.79194062
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79155829
94TP53_18474530_ChIP-ChIP_U2OS_Human0.78541624
95BRD4_25478319_ChIP-Seq_HGPS_Human0.78507509
96WT1_19549856_ChIP-ChIP_CCG9911_Human0.78334874
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77302591
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.75817420
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.74770791
100AR_25329375_ChIP-Seq_VCAP_Human0.74722558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.44806488
2MP0003111_abnormal_nucleus_morphology3.21038919
3MP0002837_dystrophic_cardiac_calcinosis3.03824019
4MP0004957_abnormal_blastocyst_morpholog3.00479421
5MP0004043_abnormal_pH_regulation2.90261158
6MP0003941_abnormal_skin_development2.83766887
7MP0003890_abnormal_embryonic-extraembry2.82658139
8MP0003077_abnormal_cell_cycle2.63103258
9MP0003693_abnormal_embryo_hatching2.61448632
10MP0008877_abnormal_DNA_methylation2.53030962
11MP0008058_abnormal_DNA_repair2.52724641
12MP0008057_abnormal_DNA_replication2.45961291
13MP0003011_delayed_dark_adaptation2.22472052
14MP0003937_abnormal_limbs/digits/tail_de2.16078504
15MP0003787_abnormal_imprinting2.13806995
16MP0002234_abnormal_pharynx_morphology2.05891982
17MP0008932_abnormal_embryonic_tissue1.91222842
18MP0000569_abnormal_digit_pigmentation1.89766129
19MP0000534_abnormal_ureter_morphology1.86456795
20MP0008789_abnormal_olfactory_epithelium1.84085778
21MP0003718_maternal_effect1.81977740
22MP0003942_abnormal_urinary_system1.79472452
23MP0000049_abnormal_middle_ear1.79256570
24MP0001529_abnormal_vocalization1.79092600
25MP0008007_abnormal_cellular_replicative1.75533032
26MP0002396_abnormal_hematopoietic_system1.74954196
27MP0009250_abnormal_appendicular_skeleto1.72134128
28MP0006072_abnormal_retinal_apoptosis1.70059050
29MP0001485_abnormal_pinna_reflex1.67734699
30MP0006036_abnormal_mitochondrial_physio1.63589791
31MP0009697_abnormal_copulation1.61474386
32MP0005174_abnormal_tail_pigmentation1.57502284
33MP0002877_abnormal_melanocyte_morpholog1.57455687
34MP0003385_abnormal_body_wall1.57164427
35MP0002102_abnormal_ear_morphology1.53185232
36MP0000372_irregular_coat_pigmentation1.40608926
37MP0003121_genomic_imprinting1.40043961
38MP0002085_abnormal_embryonic_tissue1.34597000
39MP0001346_abnormal_lacrimal_gland1.34429282
40MP0003755_abnormal_palate_morphology1.30493598
41MP0003786_premature_aging1.27257854
42MP0008775_abnormal_heart_ventricle1.23886397
43MP0006292_abnormal_olfactory_placode1.23200507
44MP0005380_embryogenesis_phenotype1.19912092
45MP0001672_abnormal_embryogenesis/_devel1.19912092
46MP0005499_abnormal_olfactory_system1.18865257
47MP0005394_taste/olfaction_phenotype1.18865257
48MP0002177_abnormal_outer_ear1.18300478
49MP0002084_abnormal_developmental_patter1.17891332
50MP0001697_abnormal_embryo_size1.17355457
51MP0002009_preneoplasia1.15420329
52MP0002210_abnormal_sex_determination1.14246283
53MP0002163_abnormal_gland_morphology1.13206878
54MP0003186_abnormal_redox_activity1.12409927
55MP0001286_abnormal_eye_development1.11699152
56MP0002751_abnormal_autonomic_nervous1.10682388
57MP0004233_abnormal_muscle_weight1.10081501
58MP0003119_abnormal_digestive_system1.09715110
59MP0000762_abnormal_tongue_morphology1.05486710
60MP0006035_abnormal_mitochondrial_morpho1.04693922
61MP0001929_abnormal_gametogenesis1.04000699
62MP0001119_abnormal_female_reproductive1.03203317
63MP0002088_abnormal_embryonic_growth/wei1.01407991
64MP0006054_spinal_hemorrhage1.00670306
65MP0004197_abnormal_fetal_growth/weight/0.99713955
66MP0005389_reproductive_system_phenotype0.99294207
67MP0003943_abnormal_hepatobiliary_system0.99244773
68MP0002109_abnormal_limb_morphology0.96290482
69MP0000432_abnormal_head_morphology0.95813453
70MP0000350_abnormal_cell_proliferation0.95570166
71MP0003984_embryonic_growth_retardation0.95494922
72MP0005253_abnormal_eye_physiology0.93844172
73MP0003861_abnormal_nervous_system0.93745539
74MP0002098_abnormal_vibrissa_morphology0.91782371
75MP0000026_abnormal_inner_ear0.91738582
76MP0002938_white_spotting0.91247820
77MP0000371_diluted_coat_color0.91186812
78MP0002697_abnormal_eye_size0.91134873
79MP0005171_absent_coat_pigmentation0.90568262
80MP0001919_abnormal_reproductive_system0.90064438
81MP0002111_abnormal_tail_morphology0.88458384
82MP0004742_abnormal_vestibular_system0.87720410
83MP0009053_abnormal_anal_canal0.87126835
84MP0000428_abnormal_craniofacial_morphol0.86355165
85MP0002282_abnormal_trachea_morphology0.85809438
86MP0000653_abnormal_sex_gland0.85695407
87MP0003935_abnormal_craniofacial_develop0.85127479
88MP0004885_abnormal_endolymph0.82785499
89MP0001145_abnormal_male_reproductive0.82608866
90MP0001293_anophthalmia0.82474203
91MP0002080_prenatal_lethality0.82332906
92MP0004215_abnormal_myocardial_fiber0.81279169
93MP0002095_abnormal_skin_pigmentation0.80536596
94MP0004084_abnormal_cardiac_muscle0.79529137
95MP0004134_abnormal_chest_morphology0.79467227
96MP0010030_abnormal_orbit_morphology0.79273352
97MP0010307_abnormal_tumor_latency0.79020804
98MP0001324_abnormal_eye_pigmentation0.78481639
99MP0003221_abnormal_cardiomyocyte_apopto0.78009806
100MP0002233_abnormal_nose_morphology0.77833436

Predicted human phenotypes

RankGene SetZ-score
1Rectal fistula (HP:0100590)4.71476016
2Rectovaginal fistula (HP:0000143)4.71476016
3Vaginal fistula (HP:0004320)4.10744783
4Intestinal fistula (HP:0100819)4.00464487
5Volvulus (HP:0002580)3.99841791
6Chromsome breakage (HP:0040012)3.28327515
7Reticulocytopenia (HP:0001896)3.25007372
8Colon cancer (HP:0003003)3.22979300
9Hyperglycinemia (HP:0002154)3.22753008
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.19347514
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.11991925
12Abnormality of chromosome stability (HP:0003220)3.11091846
13Partial duplication of thumb phalanx (HP:0009944)3.00996362
14Partial duplication of the phalanx of hand (HP:0009999)2.97929988
15Meckel diverticulum (HP:0002245)2.91546794
16Abnormal lung lobation (HP:0002101)2.89510613
17Molar tooth sign on MRI (HP:0002419)2.75410609
18Abnormality of midbrain morphology (HP:0002418)2.75410609
19Abnormality of the ileum (HP:0001549)2.71860858
20Increased nuchal translucency (HP:0010880)2.68739384
21Hypoplasia of the pons (HP:0012110)2.55556165
22Clubbing of toes (HP:0100760)2.48709534
23Small hand (HP:0200055)2.47475666
24Abnormality of the pons (HP:0007361)2.45504992
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.45342007
26Abnormal hair whorl (HP:0010721)2.43880905
27Abnormality of the labia minora (HP:0012880)2.43188547
28Aplasia/Hypoplasia of the earlobes (HP:0009906)2.42919356
29Chronic hepatic failure (HP:0100626)2.39843335
30Duodenal stenosis (HP:0100867)2.38276135
31Small intestinal stenosis (HP:0012848)2.38276135
32Sloping forehead (HP:0000340)2.37710570
33Abnormality of the preputium (HP:0100587)2.36127274
34Pancreatic fibrosis (HP:0100732)2.33928528
35Abnormality of the carotid arteries (HP:0005344)2.33617351
36Abnormality of the duodenum (HP:0002246)2.32617327
37Hyperglycinuria (HP:0003108)2.31287578
38Cleft eyelid (HP:0000625)2.28101160
39Triphalangeal thumb (HP:0001199)2.27801482
40Microglossia (HP:0000171)2.24033549
41Glioma (HP:0009733)2.21763894
42Neoplasm of the oral cavity (HP:0100649)2.17017256
43Abnormality of the antihelix (HP:0009738)2.15454721
44Nephronophthisis (HP:0000090)2.12684537
45Ectopic kidney (HP:0000086)2.10554544
46Ependymoma (HP:0002888)2.08472494
472-3 toe syndactyly (HP:0004691)2.07596864
48Impulsivity (HP:0100710)2.06234699
49Preaxial foot polydactyly (HP:0001841)2.05194841
50Preaxial hand polydactyly (HP:0001177)2.03939882
51Rhabdomyosarcoma (HP:0002859)2.03435500
52Wrist flexion contracture (HP:0001239)2.02221089
53Fair hair (HP:0002286)2.01984657
54Cortical dysplasia (HP:0002539)2.00367327
55Aplasia/Hypoplasia of the tongue (HP:0010295)1.99698668
56Hypoplastic pelvis (HP:0008839)1.99570016
57Birth length less than 3rd percentile (HP:0003561)1.98895897
58Anencephaly (HP:0002323)1.98487364
59Abnormality of chromosome segregation (HP:0002916)1.98381660
60Patellar aplasia (HP:0006443)1.97077471
61Bifid tongue (HP:0010297)1.96848301
62Irregular epiphyses (HP:0010582)1.96528863
63Medulloblastoma (HP:0002885)1.96210930
64Acute lymphatic leukemia (HP:0006721)1.90737773
65Holoprosencephaly (HP:0001360)1.90566082
66Hyperlipoproteinemia (HP:0010980)1.89970028
67Acute encephalopathy (HP:0006846)1.89370042
68Duplication of thumb phalanx (HP:0009942)1.87408962
69Bowel diverticulosis (HP:0005222)1.85287519
70Myelodysplasia (HP:0002863)1.83683589
71Aplasia/Hypoplasia of the tibia (HP:0005772)1.83682239
72Postaxial foot polydactyly (HP:0001830)1.82485028
73Abnormality of glycine metabolism (HP:0010895)1.82406164
74Abnormality of serine family amino acid metabolism (HP:0010894)1.82406164
75Abnormal hemoglobin (HP:0011902)1.81733935
76Pancreatic cysts (HP:0001737)1.80352536
77Skull defect (HP:0001362)1.80335484
78Septate vagina (HP:0001153)1.78920525
79Genital tract atresia (HP:0001827)1.78804634
80Tracheal stenosis (HP:0002777)1.78268617
81Median cleft lip (HP:0000161)1.78105297
82Microtia (HP:0008551)1.77708471
83Aplasia/Hypoplasia of the patella (HP:0006498)1.77328406
84Facial cleft (HP:0002006)1.76705577
85Oligodactyly (hands) (HP:0001180)1.76477683
86Intestinal atresia (HP:0011100)1.76096543
87Abnormality of the renal medulla (HP:0100957)1.75609032
88Renal agenesis (HP:0000104)1.75577531
89Dandy-Walker malformation (HP:0001305)1.74726480
90Renal hypoplasia (HP:0000089)1.73729930
91Neoplasm of the adrenal cortex (HP:0100641)1.73299354
92Abnormal tarsal ossification (HP:0008369)1.72363950
93Abnormal number of incisors (HP:0011064)1.70434517
94Oligohydramnios (HP:0001562)1.69804247
95Supernumerary spleens (HP:0009799)1.68722991
96Abnormal foot bone ossification (HP:0010675)1.68655392
97Abnormality of the astrocytes (HP:0100707)1.68626089
98Astrocytoma (HP:0009592)1.68626089
99Clitoromegaly (HP:0000057)1.67345831
100Bilateral microphthalmos (HP:0007633)1.64652907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.69031685
2NEK14.36772220
3CDC74.02770557
4PLK43.97962912
5WEE13.04161177
6TRIM282.95850581
7NEK22.66817090
8PLK32.62617356
9PLK22.36354018
10TTK2.32872288
11ZAK2.19814423
12BRSK22.06946925
13MKNK22.03035328
14NEK92.01933680
15NUAK11.85369693
16PLK11.84227793
17EIF2AK11.78388275
18STK161.77101879
19PKN11.62849153
20MST41.62512376
21CHEK21.57301402
22EIF2AK31.56978083
23CDK31.54538604
24MAPK131.51661225
25CCNB11.46356165
26FRK1.30579866
27DYRK31.29715447
28TLK11.28131002
29PNCK1.26842791
30TAF11.24669671
31DMPK1.23020987
32TSSK61.20855155
33STK31.18806287
34VRK21.17276222
35AURKB1.14363275
36MKNK11.08359415
37VRK11.05214183
38ATR1.02787875
39WNK31.01559139
40MAP3K80.98826338
41MAP3K100.98708486
42EIF2AK20.98199864
43PINK10.94829583
44CDK190.87778335
45MARK30.87281361
46BMPR1B0.87084411
47BRSK10.84101693
48CHEK10.81658011
49TAOK30.76766364
50MARK10.76132263
51EPHA30.75755902
52ATM0.74382896
53RPS6KA40.72440396
54ALK0.71756643
55MELK0.70961141
56MAP3K40.67860130
57MAP4K20.66134729
58MAP2K70.64362884
59AURKA0.61654219
60SRPK10.61305283
61GRK10.61044954
62BCR0.60730286
63STK100.58314337
64LIMK10.55237669
65PIK3CA0.53827767
66CDK140.51602014
67CDK10.50177160
68CDK90.49602883
69CDK180.48820180
70CDK150.47494490
71CDK11A0.47081986
72EPHA40.47047418
73CDK70.46641070
74ACVR1B0.44335356
75ROCK10.42987282
76PRKCI0.42167907
77GRK70.41211199
78PAK30.40371236
79MAP3K140.40187267
80PRKCG0.38887993
81ADRBK20.38764691
82CSNK1G10.38123830
83STK390.37428731
84PDK20.37218406
85KSR10.35284821
86PRKDC0.35006160
87CDK20.34083392
88MYLK0.32362090
89CAMK1G0.30808273
90ABL20.30433482
91CSNK1G30.30170775
92ADRBK10.30128871
93OXSR10.28701007
94TNIK0.28393756
95CSNK2A10.28344225
96CSNK1G20.28214761
97DYRK20.27961603
98CDK40.27427549
99NEK60.24914787
100IRAK20.22733201

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034604.05905471
2Mismatch repair_Homo sapiens_hsa034303.82174459
3Homologous recombination_Homo sapiens_hsa034403.66280790
4Non-homologous end-joining_Homo sapiens_hsa034503.65172301
5DNA replication_Homo sapiens_hsa030303.39640204
6Proteasome_Homo sapiens_hsa030503.04102988
7Cell cycle_Homo sapiens_hsa041102.90363639
8Protein export_Homo sapiens_hsa030602.90064473
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.70359777
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28554453
11Basal transcription factors_Homo sapiens_hsa030222.24481508
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.23369286
13RNA transport_Homo sapiens_hsa030132.19855980
14RNA polymerase_Homo sapiens_hsa030202.13109655
15RNA degradation_Homo sapiens_hsa030182.11663105
16Base excision repair_Homo sapiens_hsa034102.07719839
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07221795
18One carbon pool by folate_Homo sapiens_hsa006702.06849226
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02099090
20Spliceosome_Homo sapiens_hsa030401.96661696
21Nucleotide excision repair_Homo sapiens_hsa034201.88666924
22Ribosome_Homo sapiens_hsa030101.72873194
23Sulfur relay system_Homo sapiens_hsa041221.66496576
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62374553
25Oocyte meiosis_Homo sapiens_hsa041141.61898332
26p53 signaling pathway_Homo sapiens_hsa041151.60359611
27Propanoate metabolism_Homo sapiens_hsa006401.53050756
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46298034
29Steroid biosynthesis_Homo sapiens_hsa001001.36835741
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33059264
31Pyrimidine metabolism_Homo sapiens_hsa002401.27820002
32Basal cell carcinoma_Homo sapiens_hsa052171.20019625
33Folate biosynthesis_Homo sapiens_hsa007901.16435740
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.15619465
35Nitrogen metabolism_Homo sapiens_hsa009101.15374550
36Fatty acid elongation_Homo sapiens_hsa000621.11907376
37Pyruvate metabolism_Homo sapiens_hsa006201.05862211
38Parkinsons disease_Homo sapiens_hsa050121.04571585
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01824409
40mRNA surveillance pathway_Homo sapiens_hsa030151.01539402
41Vitamin B6 metabolism_Homo sapiens_hsa007501.00315755
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99236190
43Oxidative phosphorylation_Homo sapiens_hsa001900.96723306
44Huntingtons disease_Homo sapiens_hsa050160.95557990
45Purine metabolism_Homo sapiens_hsa002300.91777535
46Phototransduction_Homo sapiens_hsa047440.89488276
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87749002
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.85870953
49Hippo signaling pathway_Homo sapiens_hsa043900.85046136
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84121527
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82451254
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73144534
53TGF-beta signaling pathway_Homo sapiens_hsa043500.72914947
54Wnt signaling pathway_Homo sapiens_hsa043100.65845815
55Hedgehog signaling pathway_Homo sapiens_hsa043400.57810015
56Epstein-Barr virus infection_Homo sapiens_hsa051690.57443490
57Retinol metabolism_Homo sapiens_hsa008300.52474670
58Fatty acid metabolism_Homo sapiens_hsa012120.51743336
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50897753
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50436707
61ECM-receptor interaction_Homo sapiens_hsa045120.48349818
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47471528
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45505352
64Glutathione metabolism_Homo sapiens_hsa004800.45408109
65Mineral absorption_Homo sapiens_hsa049780.42520674
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40877078
67Lysine degradation_Homo sapiens_hsa003100.38970666
68Metabolic pathways_Homo sapiens_hsa011000.37232442
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37025894
70Fatty acid degradation_Homo sapiens_hsa000710.35667638
71Butanoate metabolism_Homo sapiens_hsa006500.35024664
72Caffeine metabolism_Homo sapiens_hsa002320.34894382
73MicroRNAs in cancer_Homo sapiens_hsa052060.34305684
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34149845
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.33591582
76Alzheimers disease_Homo sapiens_hsa050100.32603540
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32239412
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31942862
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31393007
80Carbon metabolism_Homo sapiens_hsa012000.26928710
81Fat digestion and absorption_Homo sapiens_hsa049750.26543764
82Small cell lung cancer_Homo sapiens_hsa052220.25926457
83Olfactory transduction_Homo sapiens_hsa047400.23089092
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22695480
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22047654
86HTLV-I infection_Homo sapiens_hsa051660.21311820
87Melanoma_Homo sapiens_hsa052180.20877397
88Vitamin digestion and absorption_Homo sapiens_hsa049770.20173657
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18329668
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.17711908
91Glycerolipid metabolism_Homo sapiens_hsa005610.17638433
92Arginine and proline metabolism_Homo sapiens_hsa003300.16795848
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16718181
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16296518
95Primary immunodeficiency_Homo sapiens_hsa053400.14375842
96Viral carcinogenesis_Homo sapiens_hsa052030.14217645
97Tight junction_Homo sapiens_hsa045300.13697011
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.13086527
99Pathways in cancer_Homo sapiens_hsa052000.12540585
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11788009

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