MKKS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 6, also known as McKusick-Kaufman syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.43583675
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.77868009
3ATP synthesis coupled proton transport (GO:0015986)8.77868009
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.26072772
5respiratory electron transport chain (GO:0022904)7.69292509
6electron transport chain (GO:0022900)7.48389726
7protein complex biogenesis (GO:0070271)5.36165482
8chaperone-mediated protein transport (GO:0072321)5.23532526
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.11793822
10mitochondrial respiratory chain complex I assembly (GO:0032981)5.05582041
11NADH dehydrogenase complex assembly (GO:0010257)5.05582041
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.05582041
13protein neddylation (GO:0045116)5.04057754
14mitochondrial respiratory chain complex assembly (GO:0033108)4.95545976
15ATP biosynthetic process (GO:0006754)4.75555998
16regulation of mitochondrial translation (GO:0070129)4.73803381
17oxidative phosphorylation (GO:0006119)4.64191616
18hydrogen ion transmembrane transport (GO:1902600)4.61528467
19purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.42723608
20purine nucleoside triphosphate biosynthetic process (GO:0009145)4.41195975
21inner mitochondrial membrane organization (GO:0007007)4.35527197
22proton transport (GO:0015992)4.07126745
23viral transcription (GO:0019083)4.03652820
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.03620053
25cotranslational protein targeting to membrane (GO:0006613)4.02530616
26hydrogen transport (GO:0006818)4.00965279
27translational termination (GO:0006415)3.98110711
28protein targeting to ER (GO:0045047)3.95433224
29ribosomal small subunit assembly (GO:0000028)3.95160345
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.90427173
31protein localization to endoplasmic reticulum (GO:0070972)3.85852126
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.85544995
33ribonucleoside triphosphate biosynthetic process (GO:0009201)3.83629326
34respiratory chain complex IV assembly (GO:0008535)3.83218880
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.82847307
36proteasome assembly (GO:0043248)3.80273345
37ribosomal large subunit biogenesis (GO:0042273)3.77034244
38tricarboxylic acid cycle (GO:0006099)3.76226853
39NADH metabolic process (GO:0006734)3.75167459
40negative regulation of ligase activity (GO:0051352)3.71220495
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.71220495
42ribosomal small subunit biogenesis (GO:0042274)3.65787412
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.65763439
44cytochrome complex assembly (GO:0017004)3.59149342
45fatty acid elongation (GO:0030497)3.57926092
46establishment of integrated proviral latency (GO:0075713)3.57460489
47protein targeting to mitochondrion (GO:0006626)3.56386096
48ubiquinone biosynthetic process (GO:0006744)3.53321536
49quinone biosynthetic process (GO:1901663)3.53321536
50mitochondrial transport (GO:0006839)3.50731247
51translation (GO:0006412)3.48704863
52ATP hydrolysis coupled proton transport (GO:0015991)3.48509784
53energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.48509784
54nucleoside triphosphate biosynthetic process (GO:0009142)3.46954925
55aerobic respiration (GO:0009060)3.46179257
56establishment of protein localization to mitochondrion (GO:0072655)3.45812200
57translational elongation (GO:0006414)3.43675100
58ubiquinone metabolic process (GO:0006743)3.43544801
59protein localization to mitochondrion (GO:0070585)3.43066960
60aldehyde catabolic process (GO:0046185)3.42372619
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41964730
62DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.41388318
63maturation of SSU-rRNA (GO:0030490)3.40894620
64positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.37663632
65regulation of oxidative phosphorylation (GO:0002082)3.36577738
66cellular ketone body metabolic process (GO:0046950)3.34112405
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33194658
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.32961954
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.32961954
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.32961954
71tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32298568
72RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32298568
73water-soluble vitamin biosynthetic process (GO:0042364)3.32097714
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.32046944
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.32046944
76deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.29182427
77regulation of acyl-CoA biosynthetic process (GO:0050812)3.28170363
78GTP biosynthetic process (GO:0006183)3.27810242
79positive regulation of mitochondrial fission (GO:0090141)3.27807823
80chromatin remodeling at centromere (GO:0031055)3.27294491
81CENP-A containing nucleosome assembly (GO:0034080)3.26546750
82rRNA modification (GO:0000154)3.23092549
83signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19921239
84signal transduction involved in DNA damage checkpoint (GO:0072422)3.19921239
85positive regulation of ligase activity (GO:0051351)3.17407452
86signal transduction involved in cell cycle checkpoint (GO:0072395)3.15451928
87negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.14138013
88translational initiation (GO:0006413)3.13503138
89viral life cycle (GO:0019058)3.13413752
90cellular protein complex disassembly (GO:0043624)3.11881912
91regulation of cellular respiration (GO:0043457)3.11795973
92cellular respiration (GO:0045333)3.10244546
93purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.09617392
94purine nucleoside monophosphate biosynthetic process (GO:0009127)3.09617392
95cellular component biogenesis (GO:0044085)3.07337181
96intracellular protein transmembrane import (GO:0044743)3.06193199
97regulation of coenzyme metabolic process (GO:0051196)3.05734032
98regulation of cofactor metabolic process (GO:0051193)3.05734032
99termination of RNA polymerase III transcription (GO:0006386)3.05595659
100transcription elongation from RNA polymerase III promoter (GO:0006385)3.05595659
101cullin deneddylation (GO:0010388)3.03426916
102pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03312095
103substantia nigra development (GO:0021762)3.02718424
104succinate metabolic process (GO:0006105)2.99639555
105regulation of ubiquitin-protein transferase activity (GO:0051438)2.98855171
106L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98623593
107establishment of viral latency (GO:0019043)2.98606944
108regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.96439232
109nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.95811275
110quinone metabolic process (GO:1901661)2.95144260
111ketone body metabolic process (GO:1902224)2.91878811
112peptidyl-histidine modification (GO:0018202)2.88042939
113spliceosomal snRNP assembly (GO:0000387)2.85110283
114regulation of cellular amino acid metabolic process (GO:0006521)2.84276606
115purine nucleoside biosynthetic process (GO:0042451)2.83986472
116purine ribonucleoside biosynthetic process (GO:0046129)2.83986472
117regulation of ligase activity (GO:0051340)2.83441432
118dopamine transport (GO:0015872)2.83234754
119protein-cofactor linkage (GO:0018065)2.81776369
120amino acid salvage (GO:0043102)2.81678187
121L-methionine salvage (GO:0071267)2.81678187
122L-methionine biosynthetic process (GO:0071265)2.81678187
123generation of precursor metabolites and energy (GO:0006091)2.81398737
124regulation of cellular amine metabolic process (GO:0033238)2.79278636
125central nervous system myelination (GO:0022010)2.78719486
126axon ensheathment in central nervous system (GO:0032291)2.78719486
127protein deneddylation (GO:0000338)2.77601008
128histone exchange (GO:0043486)2.76392087
129metallo-sulfur cluster assembly (GO:0031163)2.75681170
130iron-sulfur cluster assembly (GO:0016226)2.75681170
131guanosine-containing compound biosynthetic process (GO:1901070)2.74795796
132cholesterol biosynthetic process (GO:0006695)2.70777266
133UTP biosynthetic process (GO:0006228)2.61842847
134branched-chain amino acid catabolic process (GO:0009083)2.55700945
135ribonucleoside monophosphate biosynthetic process (GO:0009156)2.55056777
136UTP metabolic process (GO:0046051)2.52785099
1377-methylguanosine mRNA capping (GO:0006370)2.51968122
138erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.51684874
139L-phenylalanine catabolic process (GO:0006559)2.51684874
1407-methylguanosine RNA capping (GO:0009452)2.51095760
141RNA capping (GO:0036260)2.51095760
142regulation of mitochondrial fission (GO:0090140)2.51002044
143nucleoside diphosphate phosphorylation (GO:0006165)2.50811339
144negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50750334
145protein transmembrane transport (GO:0071806)2.48626859
146removal of superoxide radicals (GO:0019430)2.46847380
147cellular response to superoxide (GO:0071451)2.46847380
148cellular response to oxygen radical (GO:0071450)2.46847380
149L-phenylalanine metabolic process (GO:0006558)2.45419751
150erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.45419751
151regulation of cell communication by electrical coupling (GO:0010649)2.44814836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.86731411
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.42522695
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.49119482
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.45150748
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16105187
6CREB1_15753290_ChIP-ChIP_HEK293T_Human2.95339851
7* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.95141946
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.94304201
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79454140
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.70957162
11VDR_22108803_ChIP-Seq_LS180_Human2.64944933
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60862824
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.58208640
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54392303
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.52601524
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.47680137
17TAF15_26573619_Chip-Seq_HEK293_Human2.39368700
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32764261
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.30363217
20GBX2_23144817_ChIP-Seq_PC3_Human2.19244197
21* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02356100
22* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96819626
23TTF2_22483619_ChIP-Seq_HELA_Human1.96819296
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96267689
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92820099
26GABP_19822575_ChIP-Seq_HepG2_Human1.87287512
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85435737
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.82833826
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77063910
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76280294
31* XRN2_22483619_ChIP-Seq_HELA_Human1.75943987
32DCP1A_22483619_ChIP-Seq_HELA_Human1.68640642
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67561838
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67426446
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62146069
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60277187
37FUS_26573619_Chip-Seq_HEK293_Human1.60245807
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57690334
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.51333412
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51294698
41E2F7_22180533_ChIP-Seq_HELA_Human1.49919313
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.48930616
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48563659
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48406265
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.47838769
46* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47574927
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44266521
48* VDR_23849224_ChIP-Seq_CD4+_Human1.42873321
49ELK1_19687146_ChIP-ChIP_HELA_Human1.40061709
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.39655487
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35280491
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33877791
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33419728
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33024532
55* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31775746
56HTT_18923047_ChIP-ChIP_STHdh_Human1.30697625
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29888582
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.28091073
59P300_19829295_ChIP-Seq_ESCs_Human1.27378510
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25831269
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25830129
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24897884
63ER_23166858_ChIP-Seq_MCF-7_Human1.24073295
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23391055
65FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22883858
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20233363
67CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.19524011
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17477308
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14633981
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14390942
71FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14297467
72ZNF274_21170338_ChIP-Seq_K562_Hela1.11539529
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10729514
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10299928
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09896253
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09079923
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07892403
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07167468
79IRF1_19129219_ChIP-ChIP_H3396_Human1.06822597
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.06423634
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05386053
82AR_21909140_ChIP-Seq_LNCAP_Human1.05353514
83EWS_26573619_Chip-Seq_HEK293_Human1.03876213
84* TP53_22573176_ChIP-Seq_HFKS_Human1.02372376
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00692363
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00583513
87* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00230612
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00032571
89NANOG_19829295_ChIP-Seq_ESCs_Human0.99471275
90SOX2_19829295_ChIP-Seq_ESCs_Human0.99471275
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97554883
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96875660
93* FOXP3_21729870_ChIP-Seq_TREG_Human0.95844898
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95377099
95JUN_21703547_ChIP-Seq_K562_Human0.93573071
96PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92976882
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92434638
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92256364
99* NANOG_16153702_ChIP-ChIP_HESCs_Human0.91978864
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91571656
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91468241
102* SOX2_16153702_ChIP-ChIP_HESCs_Human0.90885376
103IGF1R_20145208_ChIP-Seq_DFB_Human0.90854594
104E2F1_21310950_ChIP-Seq_MCF-7_Human0.90394826
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88954799
106SALL4_22934838_ChIP-ChIP_CD34+_Human0.88805066
107MYC_18940864_ChIP-ChIP_HL60_Human0.87607672
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87328031
109* SOX17_20123909_ChIP-Seq_XEN_Mouse0.87046452
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86401048
111REST_19997604_ChIP-ChIP_NEURONS_Mouse0.86386745
112PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86375871
113ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85152477
114NCOR_22424771_ChIP-Seq_293T_Human0.85150280
115KDM5A_27292631_Chip-Seq_BREAST_Human0.84784418
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84394780
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83175662
118EZH2_22144423_ChIP-Seq_EOC_Human0.82957602
119RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82619199
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82593839
121FOXM1_23109430_ChIP-Seq_U2OS_Human0.82464594
122ZNF263_19887448_ChIP-Seq_K562_Human0.82069797
123HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82014452
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81701101
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81368382
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81368382
127* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.80744666
128AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80581465
129SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80347145
130CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80280678
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79565055
132RUNX1_27457419_Chip-Seq_LIVER_Mouse0.79198271
133SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78928082
134POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.78546539
135* P53_22387025_ChIP-Seq_ESCs_Mouse0.78276967
136SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78187394
137YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78180915
138* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.77565260
139PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.74888761
140CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74323972
141SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73262174
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.69577194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.85086473
2MP0002822_catalepsy3.79786476
3MP0003806_abnormal_nucleotide_metabolis3.31877677
4MP0002837_dystrophic_cardiac_calcinosis3.31681962
5MP0006036_abnormal_mitochondrial_physio3.11381806
6MP0009379_abnormal_foot_pigmentation2.89752439
7MP0003646_muscle_fatigue2.84044737
8MP0003123_paternal_imprinting2.83538942
9MP0008875_abnormal_xenobiotic_pharmacok2.77296066
10MP0006292_abnormal_olfactory_placode2.63686419
11MP0003195_calcinosis2.45855946
12MP0002139_abnormal_hepatobiliary_system2.45325230
13MP0008058_abnormal_DNA_repair2.43893987
14MP0006035_abnormal_mitochondrial_morpho2.38531987
15MP0001905_abnormal_dopamine_level2.27179910
16MP0002736_abnormal_nociception_after2.25490078
17MP0009697_abnormal_copulation2.18318477
18MP0005360_urolithiasis2.13422113
19MP0004215_abnormal_myocardial_fiber2.12040560
20MP0003186_abnormal_redox_activity2.10709756
21MP0005085_abnormal_gallbladder_physiolo2.05962784
22* MP0001529_abnormal_vocalization2.05232932
23MP0004036_abnormal_muscle_relaxation1.95372995
24MP0005084_abnormal_gallbladder_morpholo1.92921548
25MP0004957_abnormal_blastocyst_morpholog1.91624768
26MP0001968_abnormal_touch/_nociception1.91144250
27MP0002938_white_spotting1.89406947
28MP0004043_abnormal_pH_regulation1.88781037
29MP0008932_abnormal_embryonic_tissue1.86739685
30MP0002272_abnormal_nervous_system1.80628325
31MP0003950_abnormal_plasma_membrane1.80560413
32MP0009046_muscle_twitch1.79554907
33MP0010094_abnormal_chromosome_stability1.78527348
34MP0005171_absent_coat_pigmentation1.76864111
35MP0004142_abnormal_muscle_tone1.68364098
36MP0002064_seizures1.67866760
37MP0000749_muscle_degeneration1.66904206
38MP0005451_abnormal_body_composition1.66360513
39MP0002876_abnormal_thyroid_physiology1.65057312
40MP0009745_abnormal_behavioral_response1.64090147
41MP0000751_myopathy1.63626036
42MP0006072_abnormal_retinal_apoptosis1.61793368
43MP0001440_abnormal_grooming_behavior1.58450522
44MP0003718_maternal_effect1.54855607
45MP0003693_abnormal_embryo_hatching1.53956566
46MP0005332_abnormal_amino_acid1.52711018
47MP0006276_abnormal_autonomic_nervous1.52281810
48MP0008877_abnormal_DNA_methylation1.47630463
49MP0004084_abnormal_cardiac_muscle1.46222828
50MP0005645_abnormal_hypothalamus_physiol1.43480128
51MP0005330_cardiomyopathy1.41586504
52MP0004147_increased_porphyrin_level1.39159190
53MP0002735_abnormal_chemical_nociception1.38484954
54MP0002090_abnormal_vision1.38332239
55MP0001486_abnormal_startle_reflex1.37859726
56MP0002734_abnormal_mechanical_nocicepti1.37040366
57MP0004270_analgesia1.36908691
58* MP0005386_behavior/neurological_phenoty1.35585543
59* MP0004924_abnormal_behavior1.35585543
60MP0000920_abnormal_myelination1.34712926
61MP0003121_genomic_imprinting1.34712199
62MP0008007_abnormal_cellular_replicative1.33428265
63MP0004145_abnormal_muscle_electrophysio1.33209680
64MP0003635_abnormal_synaptic_transmissio1.28766294
65MP0005423_abnormal_somatic_nervous1.27455490
66* MP0008789_abnormal_olfactory_epithelium1.27169774
67MP0003137_abnormal_impulse_conducting1.26357928
68MP0001293_anophthalmia1.25797642
69MP0003786_premature_aging1.25266258
70MP0003122_maternal_imprinting1.24478485
71MP0002972_abnormal_cardiac_muscle1.24107173
72MP0005551_abnormal_eye_electrophysiolog1.21819739
73MP0001764_abnormal_homeostasis1.20410283
74MP0005253_abnormal_eye_physiology1.20407333
75MP0002332_abnormal_exercise_endurance1.20331489
76MP0002163_abnormal_gland_morphology1.20293027
77MP0002067_abnormal_sensory_capabilities1.20135209
78MP0003111_abnormal_nucleus_morphology1.20028515
79MP0003136_yellow_coat_color1.19819361
80MP0005584_abnormal_enzyme/coenzyme_acti1.19309509
81MP0002638_abnormal_pupillary_reflex1.19206605
82MP0001501_abnormal_sleep_pattern1.18824398
83MP0003011_delayed_dark_adaptation1.16492351
84MP0005620_abnormal_muscle_contractility1.16223097
85MP0005408_hypopigmentation1.15340489
86MP0004484_altered_response_of1.13818367
87MP0002909_abnormal_adrenal_gland1.13577710
88* MP0002572_abnormal_emotion/affect_behav1.12968318
89* MP0001984_abnormal_olfaction1.11295438
90MP0003077_abnormal_cell_cycle1.10344263
91MP0005535_abnormal_body_temperature1.07677174
92MP0002063_abnormal_learning/memory/cond1.07548884
93MP0002229_neurodegeneration1.05523010
94MP0001970_abnormal_pain_threshold1.05380992
95MP0005410_abnormal_fertilization1.05289330
96MP0005636_abnormal_mineral_homeostasis1.04760550
97MP0003690_abnormal_glial_cell1.04131257
98MP0000372_irregular_coat_pigmentation1.03028785
99MP0008260_abnormal_autophagy1.01591113
100MP0002160_abnormal_reproductive_system1.01212523
101MP0003329_amyloid_beta_deposits1.01025723
102MP0002102_abnormal_ear_morphology1.00664430
103MP0005365_abnormal_bile_salt0.98359656
104MP0002095_abnormal_skin_pigmentation0.97468724
105MP0000358_abnormal_cell_content/0.97337257
106MP0002210_abnormal_sex_determination0.96423070
107MP0003787_abnormal_imprinting0.92590636
108MP0008872_abnormal_physiological_respon0.91648028
109MP0005266_abnormal_metabolism0.90975802
110MP0008004_abnormal_stomach_pH0.90941153
111MP0001986_abnormal_taste_sensitivity0.90260727
112MP0003567_abnormal_fetal_cardiomyocyte0.90158979
113MP0005379_endocrine/exocrine_gland_phen0.89069610
114MP0002733_abnormal_thermal_nociception0.87993825
115MP0000631_abnormal_neuroendocrine_gland0.87340697
116MP0008775_abnormal_heart_ventricle0.87190163
117MP0001756_abnormal_urination0.86470723
118MP0003656_abnormal_erythrocyte_physiolo0.85827733
119MP0005646_abnormal_pituitary_gland0.85629319
120MP0005389_reproductive_system_phenotype0.84791601
121MP0003221_abnormal_cardiomyocyte_apopto0.84286685
122MP0002106_abnormal_muscle_physiology0.84041191
123* MP0005394_taste/olfaction_phenotype0.83851583
124* MP0005499_abnormal_olfactory_system0.83851583
125MP0005075_abnormal_melanosome_morpholog0.83710668
126MP0000566_synostosis0.83383745
127* MP0001929_abnormal_gametogenesis0.80684853
128MP0006138_congestive_heart_failure0.80676400
129MP0002234_abnormal_pharynx_morphology0.80640760
130* MP0002066_abnormal_motor_capabilities/c0.80405663
131MP0002557_abnormal_social/conspecific_i0.78907856
132MP0002277_abnormal_respiratory_mucosa0.78441364
133MP0004133_heterotaxia0.78176830
134MP0004859_abnormal_synaptic_plasticity0.77909139
135* MP0001963_abnormal_hearing_physiology0.75782318
136MP0000747_muscle_weakness0.74565855
137MP0000653_abnormal_sex_gland0.73846237
138MP0002118_abnormal_lipid_homeostasis0.73835181
139MP0001188_hyperpigmentation0.73770896
140MP0004085_abnormal_heartbeat0.70979701
141MP0005377_hearing/vestibular/ear_phenot0.70688905
142MP0003878_abnormal_ear_physiology0.70688905
143MP0001544_abnormal_cardiovascular_syste0.70621504
144MP0005385_cardiovascular_system_phenoty0.70621504
145MP0004019_abnormal_vitamin_homeostasis0.70421327
146MP0005376_homeostasis/metabolism_phenot0.70316033
147MP0001727_abnormal_embryo_implantation0.69996635

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.87148203
2Abnormal mitochondria in muscle tissue (HP:0008316)6.43233901
3Mitochondrial inheritance (HP:0001427)6.09448316
4Acute encephalopathy (HP:0006846)6.00899291
5Progressive macrocephaly (HP:0004481)5.82080632
6Hepatocellular necrosis (HP:0001404)5.53117210
7Increased CSF lactate (HP:0002490)5.42562088
8Increased hepatocellular lipid droplets (HP:0006565)5.23620789
9Hepatic necrosis (HP:0002605)5.10894183
10Increased serum pyruvate (HP:0003542)4.94547375
11Abnormality of glycolysis (HP:0004366)4.94547375
12Lipid accumulation in hepatocytes (HP:0006561)4.89567920
13Cerebral edema (HP:0002181)4.75256877
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.40773123
15Increased intramyocellular lipid droplets (HP:0012240)4.38201850
16Renal Fanconi syndrome (HP:0001994)4.31312144
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.07475088
18Decreased activity of mitochondrial respiratory chain (HP:0008972)4.07475088
19Lactic acidosis (HP:0003128)4.00361082
20Increased muscle lipid content (HP:0009058)3.95465377
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.94508719
22Exercise intolerance (HP:0003546)3.91391942
23Respiratory failure (HP:0002878)3.81878238
243-Methylglutaconic aciduria (HP:0003535)3.72025777
25Increased serum lactate (HP:0002151)3.71338696
26Leukodystrophy (HP:0002415)3.65468861
27Optic disc pallor (HP:0000543)3.50985261
28Neuroendocrine neoplasm (HP:0100634)3.26281077
29Pheochromocytoma (HP:0002666)3.24157700
30Exertional dyspnea (HP:0002875)3.18432592
31Focal motor seizures (HP:0011153)3.04826150
32Lethargy (HP:0001254)2.99902198
33CNS demyelination (HP:0007305)2.90347852
34Abnormality of cells of the erythroid lineage (HP:0012130)2.85733517
35Abnormality of urine glucose concentration (HP:0011016)2.83061543
36Glycosuria (HP:0003076)2.83061543
37Respiratory difficulties (HP:0002880)2.82510171
38Abnormality of renal resorption (HP:0011038)2.81149247
39Reticulocytopenia (HP:0001896)2.80312019
40Macrocytic anemia (HP:0001972)2.76200632
41Abnormal number of erythroid precursors (HP:0012131)2.68719992
42Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.64836806
43Type I transferrin isoform profile (HP:0003642)2.63021581
44X-linked dominant inheritance (HP:0001423)2.59623492
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58057483
46Abnormality of alanine metabolism (HP:0010916)2.58057483
47Hyperalaninemia (HP:0003348)2.58057483
48Abnormal protein N-linked glycosylation (HP:0012347)2.50607049
49Abnormal protein glycosylation (HP:0012346)2.50607049
50Abnormal glycosylation (HP:0012345)2.50607049
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.50607049
52Methylmalonic aciduria (HP:0012120)2.47622335
53Dicarboxylic aciduria (HP:0003215)2.43070863
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.43070863
55Microvesicular hepatic steatosis (HP:0001414)2.41814054
56Emotional lability (HP:0000712)2.41445768
57Hyperventilation (HP:0002883)2.40789063
58Methylmalonic acidemia (HP:0002912)2.40641906
59Congenital, generalized hypertrichosis (HP:0004540)2.36224982
60Hyperphosphaturia (HP:0003109)2.33558277
61Sensory axonal neuropathy (HP:0003390)2.28676236
62Muscle hypertrophy of the lower extremities (HP:0008968)2.22814401
63Degeneration of anterior horn cells (HP:0002398)2.21521759
64Abnormality of the anterior horn cell (HP:0006802)2.21521759
65Progressive external ophthalmoplegia (HP:0000590)2.20830733
66Reduced antithrombin III activity (HP:0001976)2.20389910
67Vomiting (HP:0002013)2.19915343
68Ragged-red muscle fibers (HP:0003200)2.19011881
69Cerebral hemorrhage (HP:0001342)2.15309073
70Hyperglycinemia (HP:0002154)2.10828992
71Parakeratosis (HP:0001036)2.07743008
72Rhabdomyolysis (HP:0003201)2.05818445
73Generalized aminoaciduria (HP:0002909)2.05718132
74Renal cortical cysts (HP:0000803)2.00128594
75Palpitations (HP:0001962)1.99774983
76Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97270136
77Cerebral hypomyelination (HP:0006808)1.96535328
78Hypoglycemic coma (HP:0001325)1.96534348
79Calf muscle hypertrophy (HP:0008981)1.96269203
80Gliosis (HP:0002171)1.94132078
81Abnormal urine phosphate concentration (HP:0012599)1.93542354
82Congenital ichthyosiform erythroderma (HP:0007431)1.90302944
83Metabolic acidosis (HP:0001942)1.89979456
84Renal tubular dysfunction (HP:0000124)1.89905482
85Atonic seizures (HP:0010819)1.89540632
86* Medial flaring of the eyebrow (HP:0010747)1.88916270
87Degeneration of the lateral corticospinal tracts (HP:0002314)1.87603621
88Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87603621
89Conjunctival hamartoma (HP:0100780)1.83670188
90Abnormality of fatty-acid metabolism (HP:0004359)1.83582899
91Colon cancer (HP:0003003)1.81747616
92Abnormality of glycine metabolism (HP:0010895)1.81269163
93Abnormality of serine family amino acid metabolism (HP:0010894)1.81269163
94Abnormality of midbrain morphology (HP:0002418)1.80577582
95Molar tooth sign on MRI (HP:0002419)1.80577582
96Aplastic anemia (HP:0001915)1.80472099
97Myokymia (HP:0002411)1.79834162
98Abnormality of serum amino acid levels (HP:0003112)1.79052530
99Abnormal pupillary function (HP:0007686)1.78938679
100Epileptic encephalopathy (HP:0200134)1.75546580
101Blindness (HP:0000618)1.75081204
102Hyperammonemia (HP:0001987)1.74616971
103Pallor (HP:0000980)1.74100068
104Myoglobinuria (HP:0002913)1.73690507
105Abolished electroretinogram (ERG) (HP:0000550)1.72457686
106Hypothermia (HP:0002045)1.72123484
107Pancytopenia (HP:0001876)1.71295156
108Spastic paraparesis (HP:0002313)1.69299019
109Amniotic constriction ring (HP:0009775)1.69034137
110Abnormality of placental membranes (HP:0011409)1.69034137
111Hypobetalipoproteinemia (HP:0003563)1.68858625
112Hyperglycinuria (HP:0003108)1.68313512
113Exercise-induced myalgia (HP:0003738)1.66293586
114Delusions (HP:0000746)1.65764316
115Sudden death (HP:0001699)1.60536573
116Conjugated hyperbilirubinemia (HP:0002908)1.60467246
117Abnormality of methionine metabolism (HP:0010901)1.60379440
118Sparse eyelashes (HP:0000653)1.60292252
119Abnormality of vitamin B metabolism (HP:0004340)1.59709618
120Autoamputation (HP:0001218)1.59285409
121Neoplasm of the peripheral nervous system (HP:0100007)1.58894262
122Absence seizures (HP:0002121)1.57932434
123Microretrognathia (HP:0000308)1.56931360
124Cholecystitis (HP:0001082)1.56815922
125Abnormal gallbladder physiology (HP:0012438)1.56815922
126Septo-optic dysplasia (HP:0100842)1.56602284
127Aplasia/hypoplasia of the uterus (HP:0008684)1.56081141
128Abnormality of aspartate family amino acid metabolism (HP:0010899)1.55761637
129Meckel diverticulum (HP:0002245)1.55711902
130Exercise-induced muscle cramps (HP:0003710)1.53655923
131Dialeptic seizures (HP:0011146)1.53638373
132Intrahepatic cholestasis (HP:0001406)1.53584062
133Nausea (HP:0002018)1.53558547
134Hyperinsulinemic hypoglycemia (HP:0000825)1.53365164
135Abnormality of magnesium homeostasis (HP:0004921)1.52775466
136Delayed CNS myelination (HP:0002188)1.52413439
137Muscle stiffness (HP:0003552)1.51303213
138Abnormality of the vitamin B12 metabolism (HP:0004341)1.51213322
139Absent thumb (HP:0009777)1.51130547

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.27607636
2CASK3.22220300
3MAP3K123.20251133
4NME23.04535404
5NME12.97651225
6STK392.88754465
7PBK2.70793298
8OXSR12.44176045
9ARAF2.39653003
10BCKDK2.19966782
11MST1R2.15629529
12EIF2AK12.00537925
13MAP4K21.94662108
14RIPK41.91023326
15LIMK11.85930054
16OBSCN1.83252265
17WNK41.82456151
18MST41.81009091
19BUB11.76861693
20PLK21.72652049
21MAP2K71.71833769
22PIK3CA1.71011533
23MYLK1.70581444
24BRAF1.67992348
25CDC71.65350784
26TESK11.61561318
27STK241.61256552
28LMTK21.58862719
29CDK191.56953138
30PLK41.53718571
31BCR1.53471021
32STK38L1.51941276
33MAP3K41.49350521
34PDK41.45103929
35PDK31.45103929
36BMPR21.42313782
37TTK1.42027739
38GRK71.38464951
39GRK51.33116493
40NUAK11.33079695
41DAPK11.29220545
42CCNB11.28307491
43PNCK1.27270061
44PLK11.27190821
45CAMK2D1.26075774
46TRIM281.26053812
47MAP2K41.26021119
48SCYL21.21728724
49TESK21.18699724
50CAMK2B1.17035937
51ABL21.12172547
52STK161.11521930
53MUSK1.10199704
54BMPR1B1.09766210
55EPHA41.08513681
56PINK11.06337457
57EIF2AK31.04483453
58BRSK11.02627854
59CAMK2G1.01832200
60MAP3K110.99863297
61TLK10.96504618
62WEE10.96340950
63PDK20.95639858
64CAMK2A0.93226373
65TAF10.90811645
66NTRK30.90509422
67CSNK1A1L0.86754680
68VRK10.85582412
69MET0.83657164
70CSNK1G30.83523651
71AKT30.82306133
72TNIK0.81837523
73ERBB30.78255658
74AURKB0.77276423
75PKN10.74762479
76DAPK30.74679453
77PRKCE0.74567047
78GRK10.71255503
79TSSK60.71015752
80NEK10.70525612
81SRPK10.68802514
82MINK10.67612789
83IRAK30.67123656
84ADRBK20.66049337
85CDK80.65797339
86CSNK1G20.65647108
87ADRBK10.65284014
88PLK30.63187313
89PHKG10.61587310
90PHKG20.61587310
91PIM20.57532244
92ROCK20.55670255
93NEK60.55518751
94PRKACA0.55099157
95FRK0.54819584
96PRKCG0.54310653
97WNK30.52080640
98ZAK0.52073879
99CDK140.48418115
100STK40.48025092
101AURKA0.47840141
102DYRK30.44776358
103CSNK1E0.44236428
104INSRR0.43588322
105CHEK20.43565266
106CSNK1G10.43521316
107ERBB40.42797351
108PASK0.42704071
109CAMKK20.41951836
110PAK10.41576555
111ATR0.41441760
112NEK20.40971690
113SGK4940.39289289
114SGK2230.39289289
115PRPF4B0.38933408
116DAPK20.38884351
117PDPK10.38804499
118CSNK2A10.38003040
119EIF2AK20.37897217
120MAPK130.37075742
121CDK150.36572336
122PTK2B0.36288706
123MAP2K10.36120834
124CDK11A0.35765583
125ILK0.34961099
126DYRK20.33958321
127MOS0.32596152
128PRKCA0.31143665
129CSNK2A20.30837186
130YES10.30680398
131CDK180.29922290
132BRSK20.29804510

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.77693531
2Parkinsons disease_Homo sapiens_hsa050124.88619194
3Alzheimers disease_Homo sapiens_hsa050103.74937467
4Huntingtons disease_Homo sapiens_hsa050163.35359076
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.02323007
6Proteasome_Homo sapiens_hsa030502.77480477
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66447471
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.58315904
9Cardiac muscle contraction_Homo sapiens_hsa042602.52022723
10Sulfur metabolism_Homo sapiens_hsa009202.50148634
11Fatty acid elongation_Homo sapiens_hsa000622.15908035
12Mismatch repair_Homo sapiens_hsa034302.14398364
13Ribosome_Homo sapiens_hsa030102.02513360
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02028153
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.97066119
16RNA polymerase_Homo sapiens_hsa030201.93285945
17Collecting duct acid secretion_Homo sapiens_hsa049661.92693803
18DNA replication_Homo sapiens_hsa030301.86389925
19Pyruvate metabolism_Homo sapiens_hsa006201.84004600
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77158635
21Butanoate metabolism_Homo sapiens_hsa006501.76968308
22Propanoate metabolism_Homo sapiens_hsa006401.76731981
23Protein export_Homo sapiens_hsa030601.73467717
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72677297
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51193463
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38777473
27Base excision repair_Homo sapiens_hsa034101.35180565
28Carbon metabolism_Homo sapiens_hsa012001.31247948
29Peroxisome_Homo sapiens_hsa041461.27173088
30One carbon pool by folate_Homo sapiens_hsa006701.26849412
31Spliceosome_Homo sapiens_hsa030401.26836501
32Steroid biosynthesis_Homo sapiens_hsa001001.25791255
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22085406
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21852176
35RNA degradation_Homo sapiens_hsa030181.18469436
36Fatty acid degradation_Homo sapiens_hsa000711.16229562
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.10786271
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09842987
39Sulfur relay system_Homo sapiens_hsa041221.09459950
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.08476652
41Folate biosynthesis_Homo sapiens_hsa007901.05415702
42Vibrio cholerae infection_Homo sapiens_hsa051101.04885896
43Fanconi anemia pathway_Homo sapiens_hsa034601.02133604
44Vitamin B6 metabolism_Homo sapiens_hsa007500.99957377
45Metabolic pathways_Homo sapiens_hsa011000.97982525
46Fatty acid metabolism_Homo sapiens_hsa012120.90389492
47RNA transport_Homo sapiens_hsa030130.90356302
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89594867
49Synaptic vesicle cycle_Homo sapiens_hsa047210.88087848
50Glutathione metabolism_Homo sapiens_hsa004800.87568985
51Nicotine addiction_Homo sapiens_hsa050330.84852853
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84472697
53Pyrimidine metabolism_Homo sapiens_hsa002400.82464895
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81652855
55Phenylalanine metabolism_Homo sapiens_hsa003600.79072551
56Tyrosine metabolism_Homo sapiens_hsa003500.79020347
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.78394793
58Non-homologous end-joining_Homo sapiens_hsa034500.75012029
59Nitrogen metabolism_Homo sapiens_hsa009100.74731354
60Histidine metabolism_Homo sapiens_hsa003400.73354864
61Arginine and proline metabolism_Homo sapiens_hsa003300.71714066
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71180228
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70619523
64Biosynthesis of amino acids_Homo sapiens_hsa012300.68168190
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67556099
66Chemical carcinogenesis_Homo sapiens_hsa052040.67293638
67Phototransduction_Homo sapiens_hsa047440.65316457
68Tryptophan metabolism_Homo sapiens_hsa003800.64566472
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63932645
70Purine metabolism_Homo sapiens_hsa002300.63068214
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62817512
72Oocyte meiosis_Homo sapiens_hsa041140.60639299
73Rheumatoid arthritis_Homo sapiens_hsa053230.60631013
74beta-Alanine metabolism_Homo sapiens_hsa004100.58794283
75Linoleic acid metabolism_Homo sapiens_hsa005910.53215105
76Ether lipid metabolism_Homo sapiens_hsa005650.53042541
77Retinol metabolism_Homo sapiens_hsa008300.52235940
78Cell cycle_Homo sapiens_hsa041100.51605672
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50800939
80N-Glycan biosynthesis_Homo sapiens_hsa005100.50483830
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50382666
82Arachidonic acid metabolism_Homo sapiens_hsa005900.50360536
83Fructose and mannose metabolism_Homo sapiens_hsa000510.48885746
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48619111
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47486994
86Serotonergic synapse_Homo sapiens_hsa047260.47264916
87GABAergic synapse_Homo sapiens_hsa047270.46943136
88Arginine biosynthesis_Homo sapiens_hsa002200.46787338
89Regulation of autophagy_Homo sapiens_hsa041400.43497403
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42787888
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41700477
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41480577
93Pentose phosphate pathway_Homo sapiens_hsa000300.40901191
94Taste transduction_Homo sapiens_hsa047420.40423387
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.39904935
96PPAR signaling pathway_Homo sapiens_hsa033200.38339468
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38029514
98Basal transcription factors_Homo sapiens_hsa030220.37965339
99Fat digestion and absorption_Homo sapiens_hsa049750.37608495
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37261575
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35895692
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35253404
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.34453954
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33823857
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.32042795
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31808957
107Morphine addiction_Homo sapiens_hsa050320.27252796
108Starch and sucrose metabolism_Homo sapiens_hsa005000.25669623
109Caffeine metabolism_Homo sapiens_hsa002320.23670749
110Phagosome_Homo sapiens_hsa041450.22817312
111Nucleotide excision repair_Homo sapiens_hsa034200.22384279
112Galactose metabolism_Homo sapiens_hsa000520.21800534
113Mineral absorption_Homo sapiens_hsa049780.21403040
114Glycerolipid metabolism_Homo sapiens_hsa005610.21366984
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19068691
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17735447
117Glutamatergic synapse_Homo sapiens_hsa047240.15875578
118Amphetamine addiction_Homo sapiens_hsa050310.15636427
119Calcium signaling pathway_Homo sapiens_hsa040200.15334223
120Homologous recombination_Homo sapiens_hsa034400.14514645
121Dopaminergic synapse_Homo sapiens_hsa047280.13838309

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