MKL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.68257712
2negative regulation of cell killing (GO:0031342)5.68257712
3positive regulation of gamma-delta T cell activation (GO:0046645)5.29687546
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.98209356
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.98209356
6antigen processing and presentation of endogenous antigen (GO:0019883)4.95819644
7negative thymic T cell selection (GO:0045060)4.71455747
8response to peptidoglycan (GO:0032494)4.65970065
9NIK/NF-kappaB signaling (GO:0038061)4.65188429
10negative T cell selection (GO:0043383)4.57588300
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.31292294
12detection of other organism (GO:0098543)4.20837261
13regulation of gamma-delta T cell differentiation (GO:0045586)4.18166436
14detection of bacterium (GO:0016045)4.17163666
15thymic T cell selection (GO:0045061)4.13302523
16regulation of interleukin-12 biosynthetic process (GO:0045075)4.10073375
17positive thymic T cell selection (GO:0045059)4.08076238
18regulation of B cell receptor signaling pathway (GO:0050855)4.02928501
19regulation of gamma-delta T cell activation (GO:0046643)3.92029107
20leukocyte aggregation (GO:0070486)3.88944088
21T cell selection (GO:0045058)3.81780659
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.61947047
23response to host immune response (GO:0052572)3.61947047
24B cell receptor signaling pathway (GO:0050853)3.57419494
25response to interleukin-15 (GO:0070672)3.51719671
26response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.48393606
27response to host (GO:0075136)3.48393606
28response to host defenses (GO:0052200)3.48393606
29regulation of mast cell degranulation (GO:0043304)3.45696674
30Arp2/3 complex-mediated actin nucleation (GO:0034314)3.44501029
31detection of external biotic stimulus (GO:0098581)3.43805520
32positive T cell selection (GO:0043368)3.38368747
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33166012
34regulation of T cell tolerance induction (GO:0002664)3.33046840
35regulation of T-helper 2 cell differentiation (GO:0045628)3.32559424
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.31558226
37defense response to protozoan (GO:0042832)3.27847687
38regulation of leukocyte degranulation (GO:0043300)3.27826365
39T cell migration (GO:0072678)3.26234586
40regulation of myeloid leukocyte mediated immunity (GO:0002886)3.25222105
41cellular response to type I interferon (GO:0071357)3.24944090
42regulation of B cell differentiation (GO:0045577)3.24759465
43mannose metabolic process (GO:0006013)3.21673521
44natural killer cell differentiation (GO:0001779)3.18204363
45negative regulation of leukocyte mediated immunity (GO:0002704)3.15123518
46negative regulation of cAMP-mediated signaling (GO:0043951)3.14060138
47cellular response to interleukin-15 (GO:0071350)3.14020372
48regulation of mast cell activation involved in immune response (GO:0033006)3.13329519
49negative regulation of T cell mediated immunity (GO:0002710)3.13248536
50antigen processing and presentation via MHC class Ib (GO:0002475)3.11129084
51response to muramyl dipeptide (GO:0032495)3.10039575
52respiratory burst (GO:0045730)3.09547963
53regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08411670
54response to protozoan (GO:0001562)3.08102915
55JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.05024095
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.04071175
57myeloid dendritic cell differentiation (GO:0043011)3.02263243
58detection of biotic stimulus (GO:0009595)3.01237097
59negative regulation of phagocytosis (GO:0050765)2.99220468
60detection of molecule of bacterial origin (GO:0032490)2.95391739
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93514221
62positive regulation of B cell differentiation (GO:0045579)2.93456412
63negative regulation of interleukin-6 production (GO:0032715)2.92863647
64myeloid dendritic cell activation (GO:0001773)2.92693497
65mature B cell differentiation (GO:0002335)2.92539193
66neutrophil activation (GO:0042119)2.91860243
67interferon-gamma-mediated signaling pathway (GO:0060333)2.91493852
68positive regulation of lamellipodium assembly (GO:0010592)2.88606230
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.88133763
70interferon-gamma production (GO:0032609)2.87036681
71neutrophil activation involved in immune response (GO:0002283)2.86519169
72leukocyte cell-cell adhesion (GO:0007159)2.84450559
73macrophage activation (GO:0042116)2.84009224
74positive regulation of natural killer cell differentiation (GO:0032825)2.83134251
75positive regulation of type 2 immune response (GO:0002830)2.82358411
76tolerance induction (GO:0002507)2.82071241
77positive regulation of mast cell activation (GO:0033005)2.81971132
78B cell mediated immunity (GO:0019724)2.79281603
79negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.79224004
80lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78978062
81antigen receptor-mediated signaling pathway (GO:0050851)2.78697569
82leukocyte degranulation (GO:0043299)2.78661192
83T cell costimulation (GO:0031295)2.78020330
84regulation of regulated secretory pathway (GO:1903305)2.77624979
85positive regulation of histone deacetylation (GO:0031065)2.77495259
86regulation of mast cell activation (GO:0033003)2.77295931
87negative regulation of innate immune response (GO:0045824)2.76447414
88granulocyte activation (GO:0036230)2.76184372
89negative regulation of type 2 immune response (GO:0002829)2.74912107
90regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74336970
91Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.73558404
92immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.73558404
93Fc-gamma receptor signaling pathway (GO:0038094)2.73558404
94T cell receptor signaling pathway (GO:0050852)2.73289788
95Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.72981374
96regulation of interferon-beta biosynthetic process (GO:0045357)2.72341335
97regulation of type 2 immune response (GO:0002828)2.72240967
98positive regulation of lamellipodium organization (GO:1902745)2.71551805
99immunoglobulin mediated immune response (GO:0016064)2.71106322
100lymphocyte costimulation (GO:0031294)2.71009151
101regulation of alpha-beta T cell proliferation (GO:0046640)2.70439026
102positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.69966365
103actin nucleation (GO:0045010)2.69603393
104negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.68836287
105positive regulation of interleukin-2 production (GO:0032743)2.68200477
106regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.65526683
107positive regulation of antigen processing and presentation (GO:0002579)2.65280454
108neutrophil mediated immunity (GO:0002446)2.65203623
109dendritic cell differentiation (GO:0097028)2.64770408
110immune response-activating cell surface receptor signaling pathway (GO:0002429)2.64290701
111modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.64165993
112modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.64165993
113positive regulation by organism of defense response of other organism involved in symbiotic interact2.64165993
114modulation by symbiont of host immune response (GO:0052553)2.64165993
115positive regulation by symbiont of host defense response (GO:0052509)2.64165993
116modulation by symbiont of host defense response (GO:0052031)2.64165993
117leukocyte migration involved in inflammatory response (GO:0002523)2.63544107
118microglial cell activation (GO:0001774)2.63142818
119positive regulation of interferon-alpha production (GO:0032727)2.62073802
120mast cell activation (GO:0045576)2.61130463
121natural killer cell mediated immunity (GO:0002228)2.59651723
122natural killer cell mediated cytotoxicity (GO:0042267)2.59651723
123signal complex assembly (GO:0007172)2.57790224
124negative regulation of interleukin-12 production (GO:0032695)2.56954889
125regulation of T cell receptor signaling pathway (GO:0050856)2.56093825
126natural killer cell activation (GO:0030101)2.54774954
127growth hormone receptor signaling pathway (GO:0060396)2.53987432
128regulation of response to interferon-gamma (GO:0060330)2.52724217
129regulation of antigen processing and presentation (GO:0002577)2.52622117
130regulation of tolerance induction (GO:0002643)2.52131232
131lymphocyte migration (GO:0072676)2.50132331
132negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.49317181
133positive regulation of isotype switching (GO:0045830)2.48730471
134regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.48577065
135regulation of necroptotic process (GO:0060544)2.47624632
136negative regulation of erythrocyte differentiation (GO:0045647)2.46922553
137germinal center formation (GO:0002467)2.45156706
138cellular extravasation (GO:0045123)2.44389961
139regulation of natural killer cell mediated immunity (GO:0002715)2.44105201
140regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.44105201
141response to type I interferon (GO:0034340)2.43820671
142positive regulation of tolerance induction (GO:0002645)2.42979047
143myeloid cell activation involved in immune response (GO:0002275)2.42050696
144positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.40439050
145macrophage activation involved in immune response (GO:0002281)2.40150255
146T cell homeostasis (GO:0043029)2.39894092
147type I interferon signaling pathway (GO:0060337)2.39223570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.45147660
2* FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.96672182
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.83040863
4MYC_22102868_ChIP-Seq_BL_Human3.72163800
5* EGR1_19374776_ChIP-ChIP_THP-1_Human3.65449096
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.58583929
7VDR_21846776_ChIP-Seq_THP-1_Human3.19796287
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.12747221
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02526950
10TCF7_22412390_ChIP-Seq_EML_Mouse2.78441646
11MAF_26560356_Chip-Seq_TH1_Human2.64336040
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.59329076
13* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53966687
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.53190822
15KDM2B_26808549_Chip-Seq_DND41_Human2.53005018
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.45387761
17* IRF8_27001747_Chip-Seq_BMDM_Mouse2.44847886
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43660694
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43148056
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.39737533
21RUNX_20019798_ChIP-Seq_JUKART_Human2.39066927
22MYB_26560356_Chip-Seq_TH2_Human2.37828156
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.35322951
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33222451
25UTX_26944678_Chip-Seq_JUKART_Human2.31808955
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29447485
27VDR_24763502_ChIP-Seq_THP-1_Human2.26510632
28ELK3_25401928_ChIP-Seq_HUVEC_Human2.19039860
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.18816821
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15448061
31SCL_19346495_ChIP-Seq_HPC-7_Human2.14024737
32MYB_26560356_Chip-Seq_TH1_Human2.10868134
33* SPI1_23127762_ChIP-Seq_K562_Human2.10854379
34BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08809353
35* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05648424
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04434086
37STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02230832
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.89503735
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87083938
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84713238
41E2F7_22180533_ChIP-Seq_HELA_Human1.76191610
42* SPI1_23547873_ChIP-Seq_NB4_Human1.72311440
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71652911
44MAF_26560356_Chip-Seq_TH2_Human1.66917260
45LXR_22292898_ChIP-Seq_THP-1_Human1.64583762
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63834610
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.62756894
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.51787390
49GATA3_27048872_Chip-Seq_THYMUS_Human1.47720985
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46981997
51* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39974272
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39578430
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36069797
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34339249
55* GATA1_19941826_ChIP-Seq_K562_Human1.32801315
56* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31822291
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30888889
58BCOR_27268052_Chip-Seq_Bcells_Human1.30814448
59BCL6_27268052_Chip-Seq_Bcells_Human1.30697033
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30026045
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29716076
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29587726
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27848639
64KDM2B_26808549_Chip-Seq_K562_Human1.27425293
65P68_20966046_ChIP-Seq_HELA_Human1.26611404
66* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26539255
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.24005536
68NCOR1_26117541_ChIP-Seq_K562_Human1.21717294
69PU_27001747_Chip-Seq_BMDM_Mouse1.21620949
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19499381
71* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18530037
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18336905
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18336429
74PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17862488
75RACK7_27058665_Chip-Seq_MCF-7_Human1.16463972
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15649878
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14844672
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13165632
79* GATA1_19941827_ChIP-Seq_MEL_Mouse1.13083517
80CIITA_25753668_ChIP-Seq_RAJI_Human1.12104730
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11834273
82* SMC4_20622854_ChIP-Seq_HELA_Human1.10934140
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.09468132
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09368416
85VDR_24787735_ChIP-Seq_THP-1_Human1.09120922
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08749782
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.06043452
88* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05673793
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.05354177
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.04114791
91DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04073522
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03363869
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02968889
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02827423
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02227315
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02016496
97EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01940939
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01317628
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00942878
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00713510
101* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00164907
102GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99348514
103GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99172781
104RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97833642
105FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97338821
106SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96853900
107GATA1_22025678_ChIP-Seq_K562_Human0.95726577
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95491589
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95070520
110DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94431567
111* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93323208
112* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92703345
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.91722470
114ELF1_20517297_ChIP-Seq_JURKAT_Human0.91533676
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89823775
116* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85637874
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85232350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system3.34133350
2MP0001835_abnormal_antigen_presentation3.32077095
3MP0003303_peritoneal_inflammation3.24362602
4MP0003724_increased_susceptibility_to3.09190713
5MP0004510_myositis2.92357290
6MP0003436_decreased_susceptibility_to2.85249445
7MP0005387_immune_system_phenotype2.82136830
8MP0001790_abnormal_immune_system2.82136830
9MP0001800_abnormal_humoral_immune2.66941600
10MP0000569_abnormal_digit_pigmentation2.58509808
11MP0002452_abnormal_antigen_presenting2.44766258
12MP0005000_abnormal_immune_tolerance2.42237131
13MP0003763_abnormal_thymus_physiology2.41134635
14MP0005671_abnormal_response_to2.37409805
15MP0003300_gastrointestinal_ulcer2.35804329
16MP0002420_abnormal_adaptive_immunity2.33521228
17MP0001819_abnormal_immune_cell2.32273039
18MP0003191_abnormal_cellular_cholesterol2.32264918
19MP0002396_abnormal_hematopoietic_system2.28531065
20MP0002166_altered_tumor_susceptibility2.28096352
21MP0002723_abnormal_immune_serum2.26904802
22MP0004808_abnormal_hematopoietic_stem2.25857767
23MP0002398_abnormal_bone_marrow2.25697125
24MP0009278_abnormal_bone_marrow2.20823914
25MP0010352_gastrointestinal_tract_polyps2.15244633
26MP0008260_abnormal_autophagy2.12849103
27MP0002419_abnormal_innate_immunity2.06670873
28MP0001348_abnormal_lacrimal_gland1.98469798
29MP0000716_abnormal_immune_system1.97465709
30MP0009785_altered_susceptibility_to1.97278008
31MP0005025_abnormal_response_to1.96538955
32MP0002405_respiratory_system_inflammati1.95744011
33MP0003705_abnormal_hypodermis_morpholog1.94028248
34MP0005076_abnormal_cell_differentiation1.90808969
35MP0004947_skin_inflammation1.85985338
36MP0005397_hematopoietic_system_phenotyp1.84492554
37MP0001545_abnormal_hematopoietic_system1.84492554
38MP0002006_tumorigenesis1.84438376
39MP0001873_stomach_inflammation1.80404678
40MP0005451_abnormal_body_composition1.78630835
41MP0003566_abnormal_cell_adhesion1.78248542
42MP0005464_abnormal_platelet_physiology1.77112627
43MP0002148_abnormal_hypersensitivity_rea1.76986519
44MP0003172_abnormal_lysosome_physiology1.73405242
45MP0002722_abnormal_immune_system1.72370404
46MP0000703_abnormal_thymus_morphology1.72211729
47MP0000689_abnormal_spleen_morphology1.72142999
48MP0002429_abnormal_blood_cell1.62537739
49* MP0003091_abnormal_cell_migration1.62400662
50MP0008961_abnormal_basal_metabolism1.59278957
51MP0009333_abnormal_splenocyte_physiolog1.54871656
52MP0005310_abnormal_salivary_gland1.51618953
53MP0010155_abnormal_intestine_physiology1.51107102
54MP0003279_aneurysm1.47186616
55MP0000858_altered_metastatic_potential1.47071059
56MP0001853_heart_inflammation1.43443982
57MP0004859_abnormal_synaptic_plasticity1.37806331
58MP0001533_abnormal_skeleton_physiology1.37240445
59MP0003183_abnormal_peptide_metabolism1.37056557
60MP0009764_decreased_sensitivity_to1.35314772
61MP0003448_altered_tumor_morphology1.32849128
62MP0001845_abnormal_inflammatory_respons1.31447423
63MP0006082_CNS_inflammation1.29400979
64MP0005023_abnormal_wound_healing1.28386681
65MP0005058_abnormal_lysosome_morphology1.25402786
66MP0002933_joint_inflammation1.25401324
67MP0002877_abnormal_melanocyte_morpholog1.24965696
68MP0003045_fibrosis1.19977334
69MP0003866_abnormal_defecation1.15329623
70MP0005174_abnormal_tail_pigmentation1.15229253
71MP0001958_emphysema1.13484924
72MP0002138_abnormal_hepatobiliary_system1.13090992
73MP0010307_abnormal_tumor_latency1.11106557
74MP0008438_abnormal_cutaneous_collagen1.08654203
75MP0000733_abnormal_muscle_development1.07778248
76MP0004381_abnormal_hair_follicle1.06645714
77MP0008004_abnormal_stomach_pH1.02564748
78MP0002132_abnormal_respiratory_system1.02243525
79MP0000490_abnormal_crypts_of1.00198369
80MP0003690_abnormal_glial_cell0.97313947
81MP0002998_abnormal_bone_remodeling0.95909598
82MP0004883_abnormal_blood_vessel0.92132251
83MP0008874_decreased_physiological_sensi0.90676251
84MP0000465_gastrointestinal_hemorrhage0.90017253
85MP0009840_abnormal_foam_cell0.89581281
86MP0003075_altered_response_to0.87138564
87MP0001851_eye_inflammation0.86739266
88MP0002019_abnormal_tumor_incidence0.85932242
89MP0000678_abnormal_parathyroid_gland0.81350886
90MP0002254_reproductive_system_inflammat0.80357627
91* MP0005621_abnormal_cell_physiology0.79282092
92MP0005164_abnormal_response_to0.79013631
93MP0000343_altered_response_to0.78101607
94MP0004858_abnormal_nervous_system0.78019789
95MP0000767_abnormal_smooth_muscle0.76823368
96MP0005623_abnormal_meninges_morphology0.75247168
97MP0008469_abnormal_protein_level0.74197437
98MP0009765_abnormal_xenobiotic_induced0.74026184
99MP0010234_abnormal_vibrissa_follicle0.73862125
100MP0005390_skeleton_phenotype0.73151078
101MP0003453_abnormal_keratinocyte_physiol0.70644477
102MP0009763_increased_sensitivity_to0.65761000
103MP0001243_abnormal_dermal_layer0.65321575
104MP0002928_abnormal_bile_duct0.64553801
105MP0001663_abnormal_digestive_system0.64111336
106MP0000681_abnormal_thyroid_gland0.63939878
107MP0003329_amyloid_beta_deposits0.63236490
108MP0001849_ear_inflammation0.62605320
109MP0000604_amyloidosis0.61456078
110MP0002163_abnormal_gland_morphology0.59499067
111MP0005409_darkened_coat_color0.58919035
112MP0000350_abnormal_cell_proliferation0.58254650
113MP0008770_decreased_survivor_rate0.57830313
114MP0004185_abnormal_adipocyte_glucose0.56022531
115MP0003795_abnormal_bone_structure0.54739158
116MP0001915_intracranial_hemorrhage0.54487761
117MP0000249_abnormal_blood_vessel0.54306807
118MP0003828_pulmonary_edema0.54084536
119MP0005166_decreased_susceptibility_to0.52842789
120MP0006054_spinal_hemorrhage0.52557050
121MP0000015_abnormal_ear_pigmentation0.52401502
122MP0000371_diluted_coat_color0.52303165
123MP0005666_abnormal_adipose_tissue0.51499580

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)3.61201583
2Eczematoid dermatitis (HP:0000976)3.61031031
3Recurrent fungal infections (HP:0002841)3.48729387
4Recurrent viral infections (HP:0004429)3.39804089
5Cellulitis (HP:0100658)3.25001439
6Recurrent bacterial skin infections (HP:0005406)3.21650718
7Elevated erythrocyte sedimentation rate (HP:0003565)3.13812906
8Chronic otitis media (HP:0000389)3.10653349
9Gastrointestinal infarctions (HP:0005244)3.09704553
10Nasal polyposis (HP:0100582)3.09021566
11Myositis (HP:0100614)3.00743767
12Abnormal delayed hypersensitivity skin test (HP:0002963)2.97076814
13Recurrent bronchitis (HP:0002837)2.96795078
14Cerebral aneurysm (HP:0004944)2.90802612
15Autoimmune thrombocytopenia (HP:0001973)2.86084363
16Abnormality of the fingertips (HP:0001211)2.79628822
17Mediastinal lymphadenopathy (HP:0100721)2.78484324
18Abnormality of T cell number (HP:0011839)2.75618639
19Encephalitis (HP:0002383)2.75152077
20T lymphocytopenia (HP:0005403)2.72099856
21Increased density of long bones (HP:0006392)2.71291298
22Keratoconjunctivitis sicca (HP:0001097)2.71157342
23Abnormality of the nasal mucosa (HP:0000433)2.62619691
24Gastrointestinal inflammation (HP:0004386)2.60619754
25Peritonitis (HP:0002586)2.58791577
26Epistaxis (HP:0000421)2.58193622
27Urticaria (HP:0001025)2.57638798
28Inflammation of the large intestine (HP:0002037)2.56923152
29Amyloidosis (HP:0011034)2.55649084
30Protrusio acetabuli (HP:0003179)2.55184342
31Verrucae (HP:0200043)2.54548526
32Papilloma (HP:0012740)2.54548526
33Panhypogammaglobulinemia (HP:0003139)2.49549011
34Dilatation of the ascending aorta (HP:0005111)2.47044119
35Increased IgE level (HP:0003212)2.46254739
36Thrombocytosis (HP:0001894)2.44248149
37Agammaglobulinemia (HP:0004432)2.43641148
38Colitis (HP:0002583)2.43511983
39Keratoconjunctivitis (HP:0001096)2.41366884
40Petechiae (HP:0000967)2.39101861
41Abnormality of glycolipid metabolism (HP:0010969)2.38033231
42Abnormality of liposaccharide metabolism (HP:0010968)2.38033231
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.38033231
44Recurrent cutaneous fungal infections (HP:0011370)2.37791410
45Chronic mucocutaneous candidiasis (HP:0002728)2.37791410
46Episodic fever (HP:0001954)2.37688014
47Sepsis (HP:0100806)2.36440276
48IgM deficiency (HP:0002850)2.35030682
49Absent frontal sinuses (HP:0002688)2.34296433
50Periodontitis (HP:0000704)2.31349711
51Meningitis (HP:0001287)2.30683736
52Hemoptysis (HP:0002105)2.30269333
53Abnormality of T cells (HP:0002843)2.28766483
54Hyperacusis (HP:0010780)2.28093944
55Fatigue (HP:0012378)2.26399461
56Gingival bleeding (HP:0000225)2.25899485
57Recurrent skin infections (HP:0001581)2.24486864
58Chest pain (HP:0100749)2.24256705
59Spinal cord lesions (HP:0100561)2.22869728
60Syringomyelia (HP:0003396)2.22869728
61Aortic aneurysm (HP:0004942)2.22113538
62Leukocytosis (HP:0001974)2.21855233
63Pustule (HP:0200039)2.20237053
64Vasculitis (HP:0002633)2.17660140
65Emphysema (HP:0002097)2.16795338
66Orchitis (HP:0100796)2.13356244
67Arterial thrombosis (HP:0004420)2.12513256
68Loss of speech (HP:0002371)2.12204079
69Frequent falls (HP:0002359)2.11443571
70Gingivitis (HP:0000230)2.11118479
71Distal upper limb amyotrophy (HP:0007149)2.07843124
72Upper limb amyotrophy (HP:0009129)2.07843124
73Slow saccadic eye movements (HP:0000514)2.07525003
74Purpura (HP:0000979)2.07149615
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.06979956
76Obstructive lung disease (HP:0006536)2.06695279
77Chronic obstructive pulmonary disease (HP:0006510)2.06695279
78Eosinophilia (HP:0001880)2.05173069
79Broad face (HP:0000283)2.04733420
80Interstitial pulmonary disease (HP:0006530)2.04081557
81Shallow orbits (HP:0000586)2.03755793
82Abnormality of macrophages (HP:0004311)2.02986075
83Hypertensive crisis (HP:0100735)2.02381931
84Increased IgM level (HP:0003496)2.01358826
85Genu recurvatum (HP:0002816)2.00283336
86Skin ulcer (HP:0200042)1.98826185
87Hypochromic anemia (HP:0001931)1.97139266
88Pulmonary infiltrates (HP:0002113)1.97069797
89Thyroiditis (HP:0100646)1.93951961
90Abnormality of polysaccharide metabolism (HP:0011012)1.93618862
91Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93618862
92Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93618862
93Obstructive sleep apnea (HP:0002870)1.93514943
94Recurrent pneumonia (HP:0006532)1.93491696
95Recurrent lower respiratory tract infections (HP:0002783)1.92091021
96Abnormality of cells of the lymphoid lineage (HP:0012140)1.91805113
97Hematochezia (HP:0002573)1.90919523
98Recurrent gram-negative bacterial infections (HP:0005420)1.90624069
99Osteolytic defects of the phalanges of the hand (HP:0009771)1.90560695
100Osteolytic defects of the hand bones (HP:0009699)1.90560695
101Polygenic inheritance (HP:0010982)1.90300502
102Spontaneous hematomas (HP:0007420)1.89662086
103Lymphopenia (HP:0001888)1.88752212
104Spondylolisthesis (HP:0003302)1.88562464
105Abnormal platelet volume (HP:0011876)1.88214236
106Viral hepatitis (HP:0006562)1.87809507
107Autoimmune hemolytic anemia (HP:0001890)1.87410070
108Long palpebral fissure (HP:0000637)1.86780410
109Mitral valve prolapse (HP:0001634)1.86056276
110Dysostosis multiplex (HP:0000943)1.84022460
111Abnormality of the pleura (HP:0002103)1.83974947
112Urinary glycosaminoglycan excretion (HP:0003541)1.83956036
113Mucopolysacchariduria (HP:0008155)1.83956036
114Increased cerebral lipofuscin (HP:0011813)1.83021423
115Hypochromic microcytic anemia (HP:0004840)1.82966765
116Acne (HP:0001061)1.81008954
117Hepatosplenomegaly (HP:0001433)1.80467965
118Distal lower limb amyotrophy (HP:0008944)1.80429336
119Persistence of primary teeth (HP:0006335)1.79450372
120Optic neuritis (HP:0100653)1.79416821
121Retrobulbar optic neuritis (HP:0100654)1.79416821
122Abnormality of T cell physiology (HP:0011840)1.79326523
123Aortic dissection (HP:0002647)1.79231909
124Abnormality of oral frenula (HP:0000190)1.78898302
125Gastrointestinal stroma tumor (HP:0100723)1.78770784
126Pulmonary embolism (HP:0002204)1.76930855
127Abnormality of eosinophils (HP:0001879)1.75602554
128Hand muscle atrophy (HP:0009130)1.75411120
129Premature rupture of membranes (HP:0001788)1.75315097
130Vertebral arch anomaly (HP:0008438)1.75258758
131Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74520764
132Prolonged bleeding time (HP:0003010)1.74182023
133Stomatitis (HP:0010280)1.72579019
134Cervical subluxation (HP:0003308)1.71985856
135Abnormality of the peritoneum (HP:0002585)1.71875035
136Osteomyelitis (HP:0002754)1.71308731
137Hypergammaglobulinemia (HP:0010702)1.71024453
138Granulocytopenia (HP:0001913)1.70832165
139Pointed chin (HP:0000307)1.70818333
140Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69400334
141Dislocated radial head (HP:0003083)1.67883325
142Vertebral compression fractures (HP:0002953)1.66508988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.04079217
2PRPF4B3.48680606
3TRIB33.03820594
4MAP3K132.62506525
5MAP3K102.58723968
6EEF2K2.54571644
7ERN12.48628016
8JAK32.37044799
9SIK22.20622388
10TYK22.16253719
11RIPK42.11997020
12GRK62.11519077
13MAP3K142.10835885
14CDK122.10188816
15PKN22.04236785
16TTN2.00241409
17JAK11.85658331
18TBK11.84321271
19MAP3K111.82871222
20STK101.78658104
21ZAP701.73783951
22KIT1.63497109
23HCK1.56490482
24MAP3K31.55463661
25SMG11.46782869
26LRRK21.44567829
27IKBKB1.41656189
28TXK1.40669193
29CSF1R1.39862765
30TAOK21.37061851
31SYK1.36996252
32IKBKE1.36390987
33BLK1.33713275
34TAOK11.33527356
35BTK1.30260245
36RPS6KA41.29990969
37MAP3K91.29832745
38FES1.27623296
39EPHB11.21931267
40CSK1.19873855
41MAP3K11.19663796
42CHUK1.18660554
43ITK1.17221269
44PTK61.14035423
45IRAK31.09715951
46FGFR41.07237859
47BMX1.07086213
48ALK1.04675531
49CDC42BPA1.01966885
50LCK1.00606510
51IRAK40.99737568
52FLT30.99489795
53CLK10.98891105
54TESK20.98309074
55RIPK10.96910429
56TESK10.94990803
57FGFR30.94807143
58SCYL20.94567153
59DMPK0.92219145
60KSR20.91490912
61MAP3K70.88525057
62PRKCH0.88504841
63MAP2K30.87592529
64PDPK10.87366227
65STK380.84927177
66MARK20.84308565
67PIM10.81002867
68CAMKK10.77102620
69MAP3K60.77071637
70MAPK120.76903534
71SIK30.75787369
72ICK0.75511340
73PRKD20.73668680
74MAPK110.73022053
75MARK30.72955966
76RET0.70615525
77PTK2B0.69609250
78NEK20.67560866
79PTK20.67428784
80JAK20.67194637
81RPS6KC10.66351872
82RPS6KL10.66351872
83PAK40.64435361
84TRPM70.63628101
85MAPK70.63609899
86CAMK1G0.63285089
87RPS6KA20.62808524
88PIK3CG0.61281783
89CDK60.59453760
90CAMK1D0.59151318
91PDGFRA0.58345459
92TNK20.58081415
93IRAK10.57910480
94PDGFRB0.57558977
95CDK40.57317701
96GRK70.57310979
97DAPK10.55877829
98SIK10.55573550
99TEC0.55476209
100PDK10.54985611
101MAP3K80.54626736
102EPHA30.52717028
103RAF10.52499581
104DYRK1B0.52162938
105TYRO30.51228168
106NLK0.50056614
107MTOR0.49981533
108PRKCQ0.49335093
109IRAK20.48975091
110LYN0.48972721
111PRKD30.48750194
112FGR0.45715635
113KDR0.44778345
114TAOK30.44359453
115MOS0.43143927
116HIPK20.42106583
117TGFBR20.41886175
118YES10.41508810
119MAPKAPK20.41350178
120STK110.40042316
121MAPK40.39774568
122SGK30.38542123
123FYN0.37913499
124RPS6KA60.37196647
125BRD40.36546468
126MATK0.36085417

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.25425718
2Primary immunodeficiency_Homo sapiens_hsa053402.20882369
3Leishmaniasis_Homo sapiens_hsa051402.03348555
4Osteoclast differentiation_Homo sapiens_hsa043802.02299777
5Staphylococcus aureus infection_Homo sapiens_hsa051501.95179034
6Autoimmune thyroid disease_Homo sapiens_hsa053201.92345142
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.90294607
8T cell receptor signaling pathway_Homo sapiens_hsa046601.77631105
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.75537380
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.74434027
11Other glycan degradation_Homo sapiens_hsa005111.71043028
12Measles_Homo sapiens_hsa051621.63693397
13Chronic myeloid leukemia_Homo sapiens_hsa052201.63019564
14Shigellosis_Homo sapiens_hsa051311.61270895
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.54717096
16Acute myeloid leukemia_Homo sapiens_hsa052211.54384333
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45290697
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.43406690
19Toxoplasmosis_Homo sapiens_hsa051451.43172595
20Chemokine signaling pathway_Homo sapiens_hsa040621.42325771
21Antigen processing and presentation_Homo sapiens_hsa046121.41565368
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40285553
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.38640255
24TNF signaling pathway_Homo sapiens_hsa046681.33714626
25Asthma_Homo sapiens_hsa053101.33398735
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.30972300
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30623867
28VEGF signaling pathway_Homo sapiens_hsa043701.27921332
29Tuberculosis_Homo sapiens_hsa051521.26718371
30Apoptosis_Homo sapiens_hsa042101.26573918
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25042206
32Hepatitis B_Homo sapiens_hsa051611.25007703
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24690002
34Non-small cell lung cancer_Homo sapiens_hsa052231.23712672
35Viral myocarditis_Homo sapiens_hsa054161.23356269
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23152698
37Pancreatic cancer_Homo sapiens_hsa052121.22521045
38Platelet activation_Homo sapiens_hsa046111.20825541
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.18485909
40Influenza A_Homo sapiens_hsa051641.13548254
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13004966
42Hematopoietic cell lineage_Homo sapiens_hsa046401.12054311
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11469268
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09850254
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08889021
46Herpes simplex infection_Homo sapiens_hsa051681.08399971
47Glioma_Homo sapiens_hsa052141.08109892
48Allograft rejection_Homo sapiens_hsa053301.04673714
49African trypanosomiasis_Homo sapiens_hsa051431.03396788
50Phagosome_Homo sapiens_hsa041451.03098564
51Small cell lung cancer_Homo sapiens_hsa052221.00795736
52Salmonella infection_Homo sapiens_hsa051321.00575323
53Prolactin signaling pathway_Homo sapiens_hsa049171.00069290
54mTOR signaling pathway_Homo sapiens_hsa041500.99288919
55Colorectal cancer_Homo sapiens_hsa052100.95547185
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95542536
57HTLV-I infection_Homo sapiens_hsa051660.93668138
58Proteoglycans in cancer_Homo sapiens_hsa052050.91573776
59Pertussis_Homo sapiens_hsa051330.90901382
60Graft-versus-host disease_Homo sapiens_hsa053320.89626268
61Rheumatoid arthritis_Homo sapiens_hsa053230.86333342
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85704760
63Focal adhesion_Homo sapiens_hsa045100.81972350
64Endometrial cancer_Homo sapiens_hsa052130.81850521
65Endocytosis_Homo sapiens_hsa041440.80921548
66MicroRNAs in cancer_Homo sapiens_hsa052060.80747653
67MAPK signaling pathway_Homo sapiens_hsa040100.79878961
68Malaria_Homo sapiens_hsa051440.79672076
69Legionellosis_Homo sapiens_hsa051340.78478823
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78233017
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77092549
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76851627
73Type II diabetes mellitus_Homo sapiens_hsa049300.76739652
74Adherens junction_Homo sapiens_hsa045200.76413495
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75500209
76Estrogen signaling pathway_Homo sapiens_hsa049150.75254588
77Epstein-Barr virus infection_Homo sapiens_hsa051690.75246648
78Viral carcinogenesis_Homo sapiens_hsa052030.75118550
79Amoebiasis_Homo sapiens_hsa051460.74909013
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.74479096
81HIF-1 signaling pathway_Homo sapiens_hsa040660.73717168
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70387496
83Rap1 signaling pathway_Homo sapiens_hsa040150.69707257
84Long-term potentiation_Homo sapiens_hsa047200.67752583
85Hepatitis C_Homo sapiens_hsa051600.67716032
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67523196
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.67483814
88ErbB signaling pathway_Homo sapiens_hsa040120.66943967
89Renal cell carcinoma_Homo sapiens_hsa052110.66943673
90Oxytocin signaling pathway_Homo sapiens_hsa049210.66634766
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66536606
92Notch signaling pathway_Homo sapiens_hsa043300.65427661
93Olfactory transduction_Homo sapiens_hsa047400.64462227
94GnRH signaling pathway_Homo sapiens_hsa049120.63933554
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63306947
96FoxO signaling pathway_Homo sapiens_hsa040680.63237447
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62488288
98Dorso-ventral axis formation_Homo sapiens_hsa043200.61665320
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.61450173
100Choline metabolism in cancer_Homo sapiens_hsa052310.61298485
101Insulin resistance_Homo sapiens_hsa049310.61144722
102p53 signaling pathway_Homo sapiens_hsa041150.60505383
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60493801
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60209651
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58776867
106Type I diabetes mellitus_Homo sapiens_hsa049400.58742142
107Lysosome_Homo sapiens_hsa041420.57373498
108Bladder cancer_Homo sapiens_hsa052190.56815851
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56507725
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56055673
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56015785
112Inositol phosphate metabolism_Homo sapiens_hsa005620.55071331
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54443222
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54387413
115Prostate cancer_Homo sapiens_hsa052150.52829421
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.52034548
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.48040313

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