MKLN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.79443592
2nuclear pore organization (GO:0006999)4.49666130
3mitotic sister chromatid cohesion (GO:0007064)4.42114522
4monoubiquitinated protein deubiquitination (GO:0035520)4.41412918
5interkinetic nuclear migration (GO:0022027)4.30752037
6protein K11-linked deubiquitination (GO:0035871)4.16997292
7cytoplasmic mRNA processing body assembly (GO:0033962)4.12077436
8presynaptic membrane assembly (GO:0097105)4.11887364
9prenylation (GO:0097354)3.98723425
10protein prenylation (GO:0018342)3.98723425
11regulation of pigment cell differentiation (GO:0050932)3.69161105
12phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.59244239
13neural tube formation (GO:0001841)3.58005972
14histone mRNA catabolic process (GO:0071044)3.46181145
15postsynaptic membrane organization (GO:0001941)3.42244780
16positive regulation of respiratory burst (GO:0060267)3.39590710
17establishment of protein localization to Golgi (GO:0072600)3.39106258
18pore complex assembly (GO:0046931)3.38894337
19histone H3-K4 trimethylation (GO:0080182)3.31781246
20developmental pigmentation (GO:0048066)3.31728633
21presynaptic membrane organization (GO:0097090)3.29083524
22cell differentiation involved in metanephros development (GO:0072202)3.13495169
23cranial nerve structural organization (GO:0021604)3.12235347
24righting reflex (GO:0060013)3.12120403
25facial nerve structural organization (GO:0021612)3.11311671
26dentate gyrus development (GO:0021542)3.10947012
27startle response (GO:0001964)3.09720795
28negative regulation of cytosolic calcium ion concentration (GO:0051481)3.09450010
29protein targeting to Golgi (GO:0000042)3.04926813
30regulation of germinal center formation (GO:0002634)3.03190530
31daunorubicin metabolic process (GO:0044597)3.03142602
32polyketide metabolic process (GO:0030638)3.03142602
33doxorubicin metabolic process (GO:0044598)3.03142602
34regulation of centriole replication (GO:0046599)3.00449445
35cAMP catabolic process (GO:0006198)2.98633093
36regulation of non-canonical Wnt signaling pathway (GO:2000050)2.98151397
37prostate gland growth (GO:0060736)2.95954692
38nucleus localization (GO:0051647)2.93095333
39genitalia morphogenesis (GO:0035112)2.92382704
40vascular smooth muscle contraction (GO:0014829)2.92157486
41negative regulation of complement activation (GO:0045916)2.91621913
42UDP-N-acetylglucosamine metabolic process (GO:0006047)2.91262983
43regulation of Rac protein signal transduction (GO:0035020)2.90565784
44cyclic nucleotide catabolic process (GO:0009214)2.88972607
45cellular response to ethanol (GO:0071361)2.88588805
46sister chromatid cohesion (GO:0007062)2.83434003
47positive regulation of developmental pigmentation (GO:0048087)2.82893443
48cellular response to sterol (GO:0036315)2.80989956
49retinal cone cell development (GO:0046549)2.79824202
50negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78997766
51regulation of relaxation of muscle (GO:1901077)2.76811769
52olfactory bulb development (GO:0021772)2.75072852
53protein heterotetramerization (GO:0051290)2.74959316
54photoreceptor cell maintenance (GO:0045494)2.74606759
55eye photoreceptor cell differentiation (GO:0001754)2.74156936
56photoreceptor cell differentiation (GO:0046530)2.74156936
57negative regulation of protein activation cascade (GO:2000258)2.73574043
58response to pheromone (GO:0019236)2.72472193
59iron ion import (GO:0097286)2.69027221
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.67713548
61regulation of protein glycosylation (GO:0060049)2.67406231
62lipid translocation (GO:0034204)2.66743354
63phospholipid translocation (GO:0045332)2.66743354
64regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.66227444
65mesenchymal cell differentiation (GO:0048762)2.64373886
66interleukin-6-mediated signaling pathway (GO:0070102)2.63427398
67CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.62700784
68Golgi to endosome transport (GO:0006895)2.60895045
69protein targeting to vacuole (GO:0006623)2.59760760
70protein targeting to lysosome (GO:0006622)2.59760760
71establishment of protein localization to vacuole (GO:0072666)2.59760760
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.59513401
73establishment of nucleus localization (GO:0040023)2.59253542
74regulation of cell communication by electrical coupling (GO:0010649)2.58881243
75positive regulation of muscle hypertrophy (GO:0014742)2.57034066
76positive regulation of cardiac muscle hypertrophy (GO:0010613)2.57034066
77negative regulation of DNA-dependent DNA replication (GO:2000104)2.56117770
78energy homeostasis (GO:0097009)2.55407714
79protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.55374579
80central nervous system neuron axonogenesis (GO:0021955)2.54980591
81embryonic retina morphogenesis in camera-type eye (GO:0060059)2.53504864
82negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.52644888
83negative regulation of translation, ncRNA-mediated (GO:0040033)2.52644888
84regulation of translation, ncRNA-mediated (GO:0045974)2.52644888
85regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.52632749
86positive regulation of protein homodimerization activity (GO:0090073)2.52336889
87cell differentiation involved in kidney development (GO:0061005)2.52229110
88regulation of DNA endoreduplication (GO:0032875)2.51597899
89regulation of centrosome duplication (GO:0010824)2.51289299
90positive regulation of cardiac muscle cell differentiation (GO:2000727)2.50376536
91protein K48-linked deubiquitination (GO:0071108)2.50001751
92neurotransmitter-gated ion channel clustering (GO:0072578)2.48896121
93G-protein coupled receptor internalization (GO:0002031)2.48430238
94detection of other organism (GO:0098543)2.48413105
95pyrimidine nucleobase catabolic process (GO:0006208)2.48208906
96DNA double-strand break processing (GO:0000729)2.48015072
97negative regulation of keratinocyte proliferation (GO:0010839)2.47921569
98regulation of transforming growth factor beta2 production (GO:0032909)2.45445918
99reflex (GO:0060004)2.44699101
100pigmentation (GO:0043473)2.42348480
101intraciliary transport (GO:0042073)2.42278029
102regulation of respiratory system process (GO:0044065)2.41995239
103androgen biosynthetic process (GO:0006702)2.41894568
104mesenchymal cell differentiation involved in kidney development (GO:0072161)2.40841480
105mesenchymal cell differentiation involved in renal system development (GO:2001012)2.40841480
106central nervous system projection neuron axonogenesis (GO:0021952)2.40791838
107T-helper cell differentiation (GO:0042093)2.40299881
108CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.40299881
109pericardium development (GO:0060039)2.39123544
110definitive hemopoiesis (GO:0060216)2.38705912
111cilium morphogenesis (GO:0060271)2.35735851
112astrocyte development (GO:0014002)2.35589883
113ionotropic glutamate receptor signaling pathway (GO:0035235)2.35551964
114melanin metabolic process (GO:0006582)2.35332719
115protein K63-linked deubiquitination (GO:0070536)2.35331637
116negative regulation of neurotransmitter secretion (GO:0046929)2.34279488
117extracellular regulation of signal transduction (GO:1900115)2.32711560
118extracellular negative regulation of signal transduction (GO:1900116)2.32711560
119negative regulation of DNA repair (GO:0045738)2.32435384
120peptidyl-lysine trimethylation (GO:0018023)2.32077329
121microtubule anchoring (GO:0034453)2.32049404
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.31417218
123nucleobase catabolic process (GO:0046113)2.30871829
124nerve growth factor signaling pathway (GO:0038180)2.30585005
125mitochondrion distribution (GO:0048311)2.30553442
126positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.30134829
127relaxation of cardiac muscle (GO:0055119)2.29204788
128positive regulation of mitotic sister chromatid separation (GO:1901970)2.29040152
129positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.29040152
130positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.29040152
131cellular response to cholesterol (GO:0071397)2.28799752
132fibroblast migration (GO:0010761)2.28464833
133regulation of cardiac muscle cell contraction (GO:0086004)2.27612990
134tachykinin receptor signaling pathway (GO:0007217)2.27540842
135regulation of timing of cell differentiation (GO:0048505)2.27410639
136detection of bacterium (GO:0016045)2.27240258
137ganglion development (GO:0061548)2.26727193
138regulation of respiratory gaseous exchange (GO:0043576)2.26632170
139protein localization to Golgi apparatus (GO:0034067)2.26344940
140regulation of synaptic transmission, GABAergic (GO:0032228)2.26242944
141replicative senescence (GO:0090399)2.25832750
142replication fork processing (GO:0031297)2.25790424
143positive regulation of neurological system process (GO:0031646)2.25555347
144dorsal/ventral axis specification (GO:0009950)2.25305006
145neuron cell-cell adhesion (GO:0007158)2.24607869
146response to folic acid (GO:0051593)2.24501739
147retrograde transport, vesicle recycling within Golgi (GO:0000301)2.24450659
148cerebral cortex development (GO:0021987)2.24287195
149L-amino acid import (GO:0043092)2.24209525
150COPII vesicle coating (GO:0048208)2.24141974
151regulation of protein polyubiquitination (GO:1902914)2.23527216
152sympathetic nervous system development (GO:0048485)2.23521921
153centriole replication (GO:0007099)2.22856545
154early endosome to late endosome transport (GO:0045022)2.22289431
155cerebellar Purkinje cell differentiation (GO:0021702)2.22152369
156regulation of cardiac muscle hypertrophy (GO:0010611)2.20906565
157DNA dealkylation (GO:0035510)2.20881181
158smooth muscle tissue development (GO:0048745)2.20311941
159adenosine metabolic process (GO:0046085)2.20299766
160serotonin receptor signaling pathway (GO:0007210)2.20186210
161negative regulation of neurotransmitter transport (GO:0051589)2.19415393
162omega-hydroxylase P450 pathway (GO:0097267)2.18294349
163response to epinephrine (GO:0071871)2.17705116
164cerebral cortex radially oriented cell migration (GO:0021799)2.16704276
165CD4-positive, alpha-beta T cell activation (GO:0035710)2.15940174
166glutamate receptor signaling pathway (GO:0007215)2.15724526
167positive regulation of cellular amide metabolic process (GO:0034250)2.15536718
168somite development (GO:0061053)2.15135950
169cell morphogenesis involved in neuron differentiation (GO:0048667)2.14003199
170lymphoid progenitor cell differentiation (GO:0002320)2.12778343
171limb development (GO:0060173)2.12393904
172appendage development (GO:0048736)2.12393904
173neuronal action potential propagation (GO:0019227)2.11128662
174import into cell (GO:0098657)2.10270946
175regulation of muscle hypertrophy (GO:0014743)2.10031084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.87576298
2GBX2_23144817_ChIP-Seq_PC3_Human3.85248955
3EZH2_22144423_ChIP-Seq_EOC_Human3.45052365
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.65407210
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62331521
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60961351
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58031077
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45863077
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39837299
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.36925200
11TAF15_26573619_Chip-Seq_HEK293_Human2.35605073
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.32617287
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.20720588
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19433324
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01661390
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.00437138
17PIAS1_25552417_ChIP-Seq_VCAP_Human2.00082639
18SUZ12_27294783_Chip-Seq_NPCs_Mouse2.00005068
19* P300_19829295_ChIP-Seq_ESCs_Human1.93000316
20NFE2_27457419_Chip-Seq_LIVER_Mouse1.88139717
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.87214645
22VDR_22108803_ChIP-Seq_LS180_Human1.86802496
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86681252
24* SMAD4_21799915_ChIP-Seq_A2780_Human1.85250076
25* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84185103
26NANOG_18555785_Chip-Seq_ESCs_Mouse1.80311812
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.78887315
28* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.78481685
29EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.77083472
30GATA1_22025678_ChIP-Seq_K562_Human1.75782481
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74374579
32E2F1_18555785_Chip-Seq_ESCs_Mouse1.73848646
33FUS_26573619_Chip-Seq_HEK293_Human1.70343864
34P53_22387025_ChIP-Seq_ESCs_Mouse1.68410784
35SUZ12_18555785_Chip-Seq_ESCs_Mouse1.64913549
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61259493
37* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.60761784
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60119749
39* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59215061
40STAT3_18555785_Chip-Seq_ESCs_Mouse1.57354734
41ER_23166858_ChIP-Seq_MCF-7_Human1.54751743
42EWS_26573619_Chip-Seq_HEK293_Human1.54725296
43P300_18555785_Chip-Seq_ESCs_Mouse1.53907107
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53152430
45NMYC_18555785_Chip-Seq_ESCs_Mouse1.52609849
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52418827
47* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51963987
48CMYC_18555785_Chip-Seq_ESCs_Mouse1.51913303
49AR_21572438_ChIP-Seq_LNCaP_Human1.51124271
50EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.50299911
51STAT3_23295773_ChIP-Seq_U87_Human1.50254250
52SOX2_18555785_Chip-Seq_ESCs_Mouse1.46813975
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45639764
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45603490
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43710813
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43710813
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.43460134
58RUNX1_27457419_Chip-Seq_LIVER_Mouse1.43390056
59* SMAD3_21741376_ChIP-Seq_EPCs_Human1.43007444
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41979476
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.41641799
62* TCF4_23295773_ChIP-Seq_U87_Human1.41219080
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39469555
64OCT4_18555785_Chip-Seq_ESCs_Mouse1.39396328
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37759265
66AR_25329375_ChIP-Seq_VCAP_Human1.37538374
67PU1_27457419_Chip-Seq_LIVER_Mouse1.37308735
68* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36981177
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36826155
70ZNF274_21170338_ChIP-Seq_K562_Hela1.36457467
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35620204
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35139348
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34466953
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33330622
75CBP_20019798_ChIP-Seq_JUKART_Human1.33330622
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33250251
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32773167
78TP53_18474530_ChIP-ChIP_U2OS_Human1.30501145
79CTCF_18555785_Chip-Seq_ESCs_Mouse1.29850147
80ZFX_18555785_Chip-Seq_ESCs_Mouse1.29406260
81IGF1R_20145208_ChIP-Seq_DFB_Human1.28587611
82TCF4_22108803_ChIP-Seq_LS180_Human1.28020250
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27695159
84RUNX2_22187159_ChIP-Seq_PCA_Human1.27330217
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26211702
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.26094175
87* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25701452
88TP53_16413492_ChIP-PET_HCT116_Human1.25600247
89CDX2_22108803_ChIP-Seq_LS180_Human1.25335973
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.25008624
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24658263
92SMAD1_18555785_Chip-Seq_ESCs_Mouse1.24403603
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24061804
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.23699263
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23654741
96ESRRB_18555785_Chip-Seq_ESCs_Mouse1.23513548
97SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22738234
98EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22373506
99RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22373506
100BCAT_22108803_ChIP-Seq_LS180_Human1.21584452
101EZH2_27304074_Chip-Seq_ESCs_Mouse1.21040755
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.20785337
103KLF4_18555785_Chip-Seq_ESCs_Mouse1.19409555
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19348613
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18557605
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18557605
107* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16941813
108OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16624137
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15825549
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.14792083
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14364610
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13449987
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13005457
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12898275
115EP300_21415370_ChIP-Seq_HL-1_Mouse1.12046688
116* BRD4_25478319_ChIP-Seq_HGPS_Human1.11807147
117* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11742394
118AHR_22903824_ChIP-Seq_MCF-7_Human1.11720203
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10881436
120FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10732321
121CJUN_26792858_Chip-Seq_BT549_Human1.10638482
122SOX2_21211035_ChIP-Seq_LN229_Gbm1.10187704
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10173730
124JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09353279
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08465558
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07708095
127SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07586701
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07576651
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05531253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.00374106
2MP0001188_hyperpigmentation4.81579817
3MP0000569_abnormal_digit_pigmentation4.34737556
4MP0005409_darkened_coat_color3.87443025
5MP0009697_abnormal_copulation3.47995158
6MP0000015_abnormal_ear_pigmentation3.12273088
7MP0002009_preneoplasia2.94957463
8MP0003890_abnormal_embryonic-extraembry2.91017597
9MP0003136_yellow_coat_color2.83831855
10MP0004147_increased_porphyrin_level2.70494695
11MP0005174_abnormal_tail_pigmentation2.65206948
12MP0003787_abnormal_imprinting2.64626031
13MP0002138_abnormal_hepatobiliary_system2.37168007
14MP0004381_abnormal_hair_follicle2.35865334
15MP0001986_abnormal_taste_sensitivity2.21105124
16MP0000372_irregular_coat_pigmentation2.17819267
17MP0005646_abnormal_pituitary_gland2.17153611
18MP0005645_abnormal_hypothalamus_physiol2.13796738
19MP0005171_absent_coat_pigmentation2.11932718
20MP0006292_abnormal_olfactory_placode2.04093996
21MP0002095_abnormal_skin_pigmentation2.01244441
22MP0000566_synostosis2.01231757
23MP0002876_abnormal_thyroid_physiology1.97555952
24MP0010352_gastrointestinal_tract_polyps1.96219117
25MP0010678_abnormal_skin_adnexa1.80684119
26MP0003195_calcinosis1.79430563
27MP0003880_abnormal_central_pattern1.78989714
28MP0008877_abnormal_DNA_methylation1.77974884
29MP0005075_abnormal_melanosome_morpholog1.67803815
30MP0006054_spinal_hemorrhage1.66950637
31MP0003937_abnormal_limbs/digits/tail_de1.62921054
32MP0005551_abnormal_eye_electrophysiolog1.62495492
33MP0003252_abnormal_bile_duct1.56195258
34MP0006072_abnormal_retinal_apoptosis1.53552745
35MP0004215_abnormal_myocardial_fiber1.50850423
36MP0003724_increased_susceptibility_to1.50837058
37MP0003941_abnormal_skin_development1.50332590
38MP0005379_endocrine/exocrine_gland_phen1.49643788
39MP0001486_abnormal_startle_reflex1.48046239
40MP0008058_abnormal_DNA_repair1.47721489
41MP0010386_abnormal_urinary_bladder1.47487883
42MP0005187_abnormal_penis_morphology1.46888760
43MP0002638_abnormal_pupillary_reflex1.45736994
44MP0002928_abnormal_bile_duct1.40178497
45MP0005248_abnormal_Harderian_gland1.37375648
46MP0001299_abnormal_eye_distance/1.35112039
47MP0004084_abnormal_cardiac_muscle1.34861390
48MP0010307_abnormal_tumor_latency1.34248007
49MP0002067_abnormal_sensory_capabilities1.34198008
50MP0003183_abnormal_peptide_metabolism1.33406362
51MP0009703_decreased_birth_body1.31849209
52MP0000647_abnormal_sebaceous_gland1.31814473
53MP0009745_abnormal_behavioral_response1.28447055
54MP0001177_atelectasis1.26500703
55MP0002233_abnormal_nose_morphology1.24078620
56MP0000428_abnormal_craniofacial_morphol1.20683132
57MP0001968_abnormal_touch/_nociception1.20446918
58MP0001879_abnormal_lymphatic_vessel1.19776520
59MP0004134_abnormal_chest_morphology1.19628375
60MP0001501_abnormal_sleep_pattern1.19006523
61MP0002166_altered_tumor_susceptibility1.17089093
62MP0001502_abnormal_circadian_rhythm1.16819318
63MP0010094_abnormal_chromosome_stability1.15226813
64MP0001270_distended_abdomen1.15026849
65MP0009046_muscle_twitch1.14562448
66MP0001186_pigmentation_phenotype1.11993723
67MP0001984_abnormal_olfaction1.11975639
68MP0003656_abnormal_erythrocyte_physiolo1.11392851
69MP0002090_abnormal_vision1.11221695
70MP0002557_abnormal_social/conspecific_i1.11029457
71MP0005423_abnormal_somatic_nervous1.10660891
72MP0002177_abnormal_outer_ear1.09655635
73MP0009379_abnormal_foot_pigmentation1.09412357
74MP0002075_abnormal_coat/hair_pigmentati1.08358384
75MP0004859_abnormal_synaptic_plasticity1.07386908
76MP0003045_fibrosis1.07191228
77MP0003635_abnormal_synaptic_transmissio1.06177190
78MP0002272_abnormal_nervous_system1.04879519
79MP0004043_abnormal_pH_regulation1.04853387
80MP0003828_pulmonary_edema1.03055954
81MP0005391_vision/eye_phenotype1.01846091
82MP0003935_abnormal_craniofacial_develop1.00837105
83MP0002572_abnormal_emotion/affect_behav1.00822164
84MP0002736_abnormal_nociception_after1.00773841
85MP0002168_other_aberrant_phenotype1.00599877
86MP0006276_abnormal_autonomic_nervous1.00317580
87MP0004145_abnormal_muscle_electrophysio0.99524346
88MP0001919_abnormal_reproductive_system0.98841508
89MP0005647_abnormal_sex_gland0.98150418
90MP0002396_abnormal_hematopoietic_system0.96662317
91MP0002163_abnormal_gland_morphology0.95905868
92MP0005253_abnormal_eye_physiology0.95618549
93MP0003868_abnormal_feces_composition0.95295974
94MP0001324_abnormal_eye_pigmentation0.94239709
95MP0003633_abnormal_nervous_system0.94131092
96MP0000631_abnormal_neuroendocrine_gland0.93972711
97MP0002938_white_spotting0.93168015
98MP0002734_abnormal_mechanical_nocicepti0.92823643
99MP0009780_abnormal_chondrocyte_physiolo0.91630550
100MP0003950_abnormal_plasma_membrane0.91292049
101MP0003943_abnormal_hepatobiliary_system0.91286497
102MP0000427_abnormal_hair_cycle0.90901971
103MP0000371_diluted_coat_color0.89705354
104MP0002084_abnormal_developmental_patter0.89170542
105MP0003385_abnormal_body_wall0.88377612
106MP0005386_behavior/neurological_phenoty0.87988764
107MP0004924_abnormal_behavior0.87988764
108MP0005671_abnormal_response_to0.87396571
109MP0002006_tumorigenesis0.84406743
110MP0001835_abnormal_antigen_presentation0.83942784
111MP0000432_abnormal_head_morphology0.82880663
112MP0002088_abnormal_embryonic_growth/wei0.82022460
113MP0002735_abnormal_chemical_nociception0.81269924
114MP0004808_abnormal_hematopoietic_stem0.78683578
115MP0004270_analgesia0.78501857
116MP0004085_abnormal_heartbeat0.78334616
117MP0003984_embryonic_growth_retardation0.78331317
118MP0003632_abnormal_nervous_system0.77910659
119MP0008569_lethality_at_weaning0.76811439
120MP0001929_abnormal_gametogenesis0.76005538
121MP0003755_abnormal_palate_morphology0.75637281
122MP0000681_abnormal_thyroid_gland0.74954082
123MP0002277_abnormal_respiratory_mucosa0.73970291
124MP0000639_abnormal_adrenal_gland0.73593050
125MP0001286_abnormal_eye_development0.73118010
126MP0003631_nervous_system_phenotype0.72757411
127MP0002064_seizures0.72377030
128MP0005395_other_phenotype0.72345140
129MP0000383_abnormal_hair_follicle0.72267474
130MP0005367_renal/urinary_system_phenotyp0.71976085
131MP0000516_abnormal_urinary_system0.71976085
132MP0008007_abnormal_cellular_replicative0.71953730
133MP0004036_abnormal_muscle_relaxation0.71656189
134MP0005334_abnormal_fat_pad0.71562968
135MP0005085_abnormal_gallbladder_physiolo0.70698205
136MP0005195_abnormal_posterior_eye0.70460981
137MP0009115_abnormal_fat_cell0.69857390
138MP0002108_abnormal_muscle_morphology0.69280803
139MP0002063_abnormal_learning/memory/cond0.69190003
140MP0004142_abnormal_muscle_tone0.68446592
141MP0003690_abnormal_glial_cell0.68306550
142MP0003121_genomic_imprinting0.67789067
143MP0008260_abnormal_autophagy0.67700643
144MP0001293_anophthalmia0.67086466
145MP0005408_hypopigmentation0.67051284
146MP0000749_muscle_degeneration0.66849053
147MP0002184_abnormal_innervation0.65974436
148MP0005380_embryogenesis_phenotype0.65798547
149MP0001672_abnormal_embryogenesis/_devel0.65798547
150MP0000778_abnormal_nervous_system0.64374071
151MP0001119_abnormal_female_reproductive0.64012787
152MP0002234_abnormal_pharynx_morphology0.63922074
153MP0002102_abnormal_ear_morphology0.63092657
154MP0000579_abnormal_nail_morphology0.60598231
155MP0009764_decreased_sensitivity_to0.59832018
156MP0004484_altered_response_of0.59708562
157MP0001764_abnormal_homeostasis0.59703348

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.47529427
2Febrile seizures (HP:0002373)4.21378903
3Hypothermia (HP:0002045)4.20546308
4Fair hair (HP:0002286)4.01545173
5Generalized hypopigmentation of hair (HP:0011358)3.87664150
6Chronic hepatic failure (HP:0100626)3.86178856
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78904455
8Protruding tongue (HP:0010808)3.46152692
9Chromsome breakage (HP:0040012)3.41524196
10Tubulointerstitial nephritis (HP:0001970)3.30827513
11Blue irides (HP:0000635)3.28122360
12Renal cortical cysts (HP:0000803)3.09802680
13Hyperventilation (HP:0002883)3.08757510
14Progressive cerebellar ataxia (HP:0002073)3.02469461
15Abnormality of the fingertips (HP:0001211)2.96635138
16Thyroid carcinoma (HP:0002890)2.95685410
17Gaze-evoked nystagmus (HP:0000640)2.92864173
18True hermaphroditism (HP:0010459)2.82796787
19Type I transferrin isoform profile (HP:0003642)2.78608552
20Aqueductal stenosis (HP:0002410)2.77186702
21Abnormal hair whorl (HP:0010721)2.70791240
22Absent eyebrow (HP:0002223)2.67522008
23Pheochromocytoma (HP:0002666)2.66071211
24Lip pit (HP:0100267)2.65448544
25Abnormality of incisor morphology (HP:0011063)2.61648654
26Patchy hypopigmentation of hair (HP:0011365)2.53362444
27Alveolar cell carcinoma (HP:0006519)2.52647583
28Abnormality of secondary sexual hair (HP:0009888)2.51956270
29Abnormality of the axillary hair (HP:0100134)2.51956270
30Absent speech (HP:0001344)2.46276753
31Hypoplastic labia majora (HP:0000059)2.44415182
32Congenital sensorineural hearing impairment (HP:0008527)2.44084601
33Midline defect of the nose (HP:0004122)2.42022832
34Abnormality of chromosome stability (HP:0003220)2.40334348
35Focal motor seizures (HP:0011153)2.39739484
36Oligodactyly (hands) (HP:0001180)2.36345551
37Genetic anticipation (HP:0003743)2.35412936
38Drooling (HP:0002307)2.34509921
39Excessive salivation (HP:0003781)2.34509921
40Neoplasm of the tracheobronchial system (HP:0100552)2.34368956
41Broad-based gait (HP:0002136)2.32345068
42Intestinal atresia (HP:0011100)2.32162679
43White forelock (HP:0002211)2.31098126
44Abnormality of the ischium (HP:0003174)2.29666544
45Volvulus (HP:0002580)2.29143932
46Nonprogressive disorder (HP:0003680)2.28442038
47Abnormality of the columella (HP:0009929)2.27181385
48Poor coordination (HP:0002370)2.26787016
49Dyschromatopsia (HP:0007641)2.22376570
50Abnormality of the labia majora (HP:0012881)2.20442632
51Prostate neoplasm (HP:0100787)2.19659940
52Rhabdomyosarcoma (HP:0002859)2.19475600
53Submucous cleft hard palate (HP:0000176)2.16152340
54Abnormality of the renal medulla (HP:0100957)2.15620167
55Abnormality of the nasal septum (HP:0000419)2.13954436
56Vertebral arch anomaly (HP:0008438)2.13499206
57Glioma (HP:0009733)2.09890230
58Thyroid-stimulating hormone excess (HP:0002925)2.08454980
59Abnormality of salivation (HP:0100755)2.08165921
60Reduced antithrombin III activity (HP:0001976)2.06272827
61Epileptic encephalopathy (HP:0200134)2.06001766
62Nephronophthisis (HP:0000090)2.05785609
63Congenital primary aphakia (HP:0007707)2.03665500
64Pancreatic fibrosis (HP:0100732)2.03585691
65Truncal obesity (HP:0001956)2.03422879
66Clubbing of toes (HP:0100760)2.02992798
67Genital tract atresia (HP:0001827)2.02725364
68Astrocytoma (HP:0009592)2.02388673
69Abnormality of the astrocytes (HP:0100707)2.02388673
70Bradycardia (HP:0001662)2.02018227
71Abolished electroretinogram (ERG) (HP:0000550)2.01844739
72Large earlobe (HP:0009748)2.01625858
73Cupped ear (HP:0000378)2.01537777
74Subacute progressive viral hepatitis (HP:0006572)2.00374348
75Low anterior hairline (HP:0000294)1.98680214
76Abnormality of the renal cortex (HP:0011035)1.98430773
77Gait imbalance (HP:0002141)1.98052000
78Abnormal biliary tract morphology (HP:0012440)1.97553317
79Gonadotropin excess (HP:0000837)1.96881521
80Medial flaring of the eyebrow (HP:0010747)1.96259777
81Neuroendocrine neoplasm (HP:0100634)1.95152086
82Transitional cell carcinoma of the bladder (HP:0006740)1.94844774
83Widely spaced teeth (HP:0000687)1.94674355
84Central scotoma (HP:0000603)1.94429879
85Bile duct proliferation (HP:0001408)1.93591214
86Abnormal biliary tract physiology (HP:0012439)1.93591214
87Decreased lacrimation (HP:0000633)1.92395580
88Scanning speech (HP:0002168)1.92236332
89Pulmonic stenosis (HP:0001642)1.91858938
90Hypochromic microcytic anemia (HP:0004840)1.90361580
91Menstrual irregularities (HP:0000858)1.90097050
92Bladder carcinoma (HP:0002862)1.90044042
93Bladder neoplasm (HP:0009725)1.90044042
94Vaginal atresia (HP:0000148)1.88783412
95Abnormality of the renal collecting system (HP:0004742)1.88699299
96Agitation (HP:0000713)1.88318434
97Neoplasm of the small intestine (HP:0100833)1.87612269
98Stomach cancer (HP:0012126)1.87038380
99Relative macrocephaly (HP:0004482)1.86442160
100Pulmonary artery stenosis (HP:0004415)1.86233061
101Ectopic kidney (HP:0000086)1.86079160
102Hypoplastic iliac wings (HP:0002866)1.85587039
103Macroorchidism (HP:0000053)1.85032388
104Congenital stationary night blindness (HP:0007642)1.83124505
105Cystic hygroma (HP:0000476)1.82416722
106Chronic diarrhea (HP:0002028)1.81734404
107Overgrowth (HP:0001548)1.81478221
108Curly hair (HP:0002212)1.80368135
109Aplasia/Hypoplasia of the fovea (HP:0008060)1.80075881
110Hypoplasia of the fovea (HP:0007750)1.80075881
111Abnormality of chromosome segregation (HP:0002916)1.79431141
112Congenital hepatic fibrosis (HP:0002612)1.78871733
113Astigmatism (HP:0000483)1.78376711
114Absent frontal sinuses (HP:0002688)1.77338531
115Abnormality of midbrain morphology (HP:0002418)1.77319132
116Molar tooth sign on MRI (HP:0002419)1.77319132
117Abnormal auditory evoked potentials (HP:0006958)1.76859527
118Narrow palate (HP:0000189)1.76838413
119Highly arched eyebrow (HP:0002553)1.75456916
120Sandal gap (HP:0001852)1.75405214
121Nephrogenic diabetes insipidus (HP:0009806)1.75334677
122Nephroblastoma (Wilms tumor) (HP:0002667)1.74721323
123Abnormality of the fovea (HP:0000493)1.73658275
124Acute myeloid leukemia (HP:0004808)1.73079229
125Aplasia/Hypoplasia of the tibia (HP:0005772)1.72554364
126Metaphyseal dysplasia (HP:0100255)1.71805492
127Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.71353276
128Abnormality of the right ventricle (HP:0001707)1.70440503
129Osteomalacia (HP:0002749)1.70261948
130Heterotopia (HP:0002282)1.70175274
131Pancreatic cysts (HP:0001737)1.69154373
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.68845184
133Degeneration of the lateral corticospinal tracts (HP:0002314)1.68845184
134Cutaneous syndactyly (HP:0012725)1.67652438
135Keratoconus (HP:0000563)1.67384208
136Increased corneal curvature (HP:0100692)1.67384208
137Short chin (HP:0000331)1.66692612
1382-3 toe syndactyly (HP:0004691)1.66124334
139Cutaneous finger syndactyly (HP:0010554)1.66008693
140Abnormality of DNA repair (HP:0003254)1.65973479
141Atonic seizures (HP:0010819)1.65829538
142Abnormality of the epiphyses of the hand (HP:0005924)1.65762387
143Long clavicles (HP:0000890)1.65486774
144Enlarged kidneys (HP:0000105)1.64954234
145Embryonal renal neoplasm (HP:0011794)1.64832876
146Attenuation of retinal blood vessels (HP:0007843)1.64723879
147Short foot (HP:0001773)1.64708444
148Pigmentary retinal degeneration (HP:0001146)1.64651529
149Aplasia/Hypoplasia of the tongue (HP:0010295)1.63849568
150Gastroesophageal reflux (HP:0002020)1.63760620
151Postaxial foot polydactyly (HP:0001830)1.63624170
152Absent hair (HP:0002298)1.63216432
153Abnormality of the prostate (HP:0008775)1.63181765
154Flat occiput (HP:0005469)1.62786805
155Exotropia (HP:0000577)1.62114764
156Thyroiditis (HP:0100646)1.61956895
157Neoplasm of the thyroid gland (HP:0100031)1.61615005
158Neoplasm of striated muscle (HP:0009728)1.61330151
159Neonatal hypoglycemia (HP:0001998)1.61255589
160Hepatoblastoma (HP:0002884)1.61073870
161Severe visual impairment (HP:0001141)1.60838823
162Biliary tract neoplasm (HP:0100574)1.60243425
163Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.59903352
164Abnormality of macular pigmentation (HP:0008002)1.59297094
165Abnormality of the frontal sinuses (HP:0002687)1.59265396
166Abnormality of the nasolacrimal system (HP:0000614)1.59215325

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.01814293
2TNIK3.80811064
3MUSK2.97021823
4INSRR2.75182345
5ZAK2.67390124
6SGK22.65782233
7AKT32.63460350
8MKNK22.32965705
9BRSK22.30903780
10BMPR1B2.20243734
11WNK32.17205513
12NUAK12.14503304
13STK392.06811127
14MAP2K72.06292383
15TXK1.99599647
16YES11.90497268
17SGK31.81221767
18IRAK31.77044300
19SGK4941.73020758
20SGK2231.73020758
21FGFR21.71928530
22MAPK131.64740108
23EIF2AK21.63175671
24MAP3K141.61436064
25STK31.61233651
26BMPR21.56240031
27NLK1.51834974
28STK38L1.51797637
29NEK61.45993095
30PNCK1.42860683
31PDK21.38973535
32MAP3K61.37898730
33IRAK41.37562491
34FRK1.35920622
35MAP3K21.31780388
36MAP4K21.29492751
37CAMKK21.26838348
38NTRK31.26291582
39FGFR31.25566870
40WEE11.19882293
41TEC1.19527279
42IRAK11.16740094
43TAOK31.12679171
44MKNK11.12200701
45TRIM281.11892277
46SRPK11.10954042
47PIK3CA1.10855253
48MAP3K121.10485331
49CDK31.10124011
50ERBB31.06321189
51BRD41.04483336
52GRK71.02849566
53MARK11.02719086
54IRAK21.01046131
55SIK30.98770231
56PRPF4B0.94238806
57MAP3K130.94204700
58PRKAA20.94066731
59FGFR10.93670455
60OXSR10.92518155
61PAK30.92365632
62ERBB40.92211025
63SGK10.90956273
64PLK30.90488966
65KSR10.89832533
66MAP3K40.89339658
67BCR0.88377005
68CAMK1D0.85818635
69OBSCN0.84539906
70PBK0.83791441
71TIE10.81677906
72TRPM70.81662357
73CAMK10.80804733
74PLK40.79329093
75FES0.79177636
76WNK40.78654308
77TNK20.78499501
78CAMK1G0.76506117
79RIPK40.75355752
80MELK0.74962505
81PDGFRB0.74526317
82MAPK70.72790503
83GRK10.72711881
84UHMK10.72323476
85PRKCQ0.71296549
86EIF2AK30.70336304
87ATM0.69865687
88PRKCE0.69315015
89NEK10.69125367
90EPHA30.67993506
91EPHA40.67876082
92ADRBK20.66910459
93IKBKE0.66289033
94PINK10.62230193
95KIT0.59835104
96WNK10.59710722
97TGFBR20.58783357
98HIPK20.57539500
99CCNB10.57302569
100PRKD20.57007904
101PIK3CG0.54860836
102MARK30.53646255
103PDGFRA0.53156665
104TGFBR10.52369546
105ACVR1B0.51992832
106PKN10.51912412
107MAP2K40.51857829
108MAPKAPK50.50718826
109CAMK40.48587012
110MET0.48046802
111PRKG10.48017698
112CAMKK10.46672128
113JAK10.45856023
114MAPK120.45834344
115IGF1R0.45357217
116CDK80.45291398
117STK40.44763915
118NEK90.43558338
119CAMK2A0.43189316
120NTRK20.42723242
121CDK60.42276744
122PRKCH0.41973552
123LATS10.41512907
124CLK10.41385769
125CHUK0.40560559
126PRKAA10.40120717
127GSK3A0.40112239
128RPS6KB10.39660582
129EIF2AK10.39306542
130CSNK1G10.39277248
131TTK0.37813892
132FER0.36337811
133RAF10.36105187
134PLK20.35577953
135CDK90.35261858
136ERBB20.34670180
137IKBKB0.33929419
138DYRK1A0.33688927
139MAPK100.33342039
140CHEK10.32755975
141MAPK110.32506986
142MYLK0.30522746
143CSNK1A1L0.30257268
144VRK10.29786473

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.04156532
2Phototransduction_Homo sapiens_hsa047442.88091866
3Propanoate metabolism_Homo sapiens_hsa006402.49305229
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29048566
5Morphine addiction_Homo sapiens_hsa050322.16258235
6Taste transduction_Homo sapiens_hsa047422.05252416
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02744357
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.96098429
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94433657
10Fanconi anemia pathway_Homo sapiens_hsa034601.94147387
11Glutamatergic synapse_Homo sapiens_hsa047241.94017513
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90674627
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81657062
14Serotonergic synapse_Homo sapiens_hsa047261.80784635
15GABAergic synapse_Homo sapiens_hsa047271.66027238
16Circadian entrainment_Homo sapiens_hsa047131.63946960
17ABC transporters_Homo sapiens_hsa020101.62820595
18Ovarian steroidogenesis_Homo sapiens_hsa049131.52487386
19Circadian rhythm_Homo sapiens_hsa047101.51031502
20Butanoate metabolism_Homo sapiens_hsa006501.47595906
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42200310
22Olfactory transduction_Homo sapiens_hsa047401.40634545
23Calcium signaling pathway_Homo sapiens_hsa040201.39910568
24Nitrogen metabolism_Homo sapiens_hsa009101.36644692
25Long-term depression_Homo sapiens_hsa047301.35564386
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32576709
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.31165551
28TGF-beta signaling pathway_Homo sapiens_hsa043501.30469976
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28171472
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27007123
31Insulin secretion_Homo sapiens_hsa049111.26127435
32Non-homologous end-joining_Homo sapiens_hsa034501.26068764
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.25470163
34Fatty acid biosynthesis_Homo sapiens_hsa000611.23070537
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22946006
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21489627
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19963544
38Selenocompound metabolism_Homo sapiens_hsa004501.19070689
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17259094
40Basal transcription factors_Homo sapiens_hsa030221.16114239
41MicroRNAs in cancer_Homo sapiens_hsa052061.15896602
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.15256382
43cAMP signaling pathway_Homo sapiens_hsa040241.14824298
44Salivary secretion_Homo sapiens_hsa049701.14413985
45Adherens junction_Homo sapiens_hsa045201.14199694
46Cholinergic synapse_Homo sapiens_hsa047251.11638364
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09986272
48Fatty acid metabolism_Homo sapiens_hsa012121.09463804
49Amphetamine addiction_Homo sapiens_hsa050311.08814687
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05085583
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03805205
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03387519
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03351758
54Glioma_Homo sapiens_hsa052141.03052203
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02606740
56Primary immunodeficiency_Homo sapiens_hsa053401.02276673
57Vitamin B6 metabolism_Homo sapiens_hsa007501.01725212
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01700188
59Vitamin digestion and absorption_Homo sapiens_hsa049770.99775745
60Fatty acid degradation_Homo sapiens_hsa000710.97885618
61One carbon pool by folate_Homo sapiens_hsa006700.97102412
62Homologous recombination_Homo sapiens_hsa034400.96585211
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.96504179
64Renin secretion_Homo sapiens_hsa049240.96287746
65RNA degradation_Homo sapiens_hsa030180.96243903
66Dorso-ventral axis formation_Homo sapiens_hsa043200.94140726
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93815041
68Lysine degradation_Homo sapiens_hsa003100.92653641
69Oocyte meiosis_Homo sapiens_hsa041140.92593627
70Melanoma_Homo sapiens_hsa052180.89042159
71Inositol phosphate metabolism_Homo sapiens_hsa005620.88531412
72Hedgehog signaling pathway_Homo sapiens_hsa043400.88422103
73Endometrial cancer_Homo sapiens_hsa052130.86746715
74Protein export_Homo sapiens_hsa030600.86303365
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85404572
76beta-Alanine metabolism_Homo sapiens_hsa004100.84662822
77Thyroid hormone synthesis_Homo sapiens_hsa049180.83812907
78Long-term potentiation_Homo sapiens_hsa047200.83581968
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.80856776
80Cell cycle_Homo sapiens_hsa041100.80611412
81Dopaminergic synapse_Homo sapiens_hsa047280.79335277
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79313580
83Measles_Homo sapiens_hsa051620.79007694
84Glycerolipid metabolism_Homo sapiens_hsa005610.78022212
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77370774
86Type II diabetes mellitus_Homo sapiens_hsa049300.76703127
87Colorectal cancer_Homo sapiens_hsa052100.76017778
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.75842925
89Sphingolipid metabolism_Homo sapiens_hsa006000.75125410
90Hematopoietic cell lineage_Homo sapiens_hsa046400.74741326
91mTOR signaling pathway_Homo sapiens_hsa041500.74120479
92Allograft rejection_Homo sapiens_hsa053300.73947886
93Autoimmune thyroid disease_Homo sapiens_hsa053200.72280751
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71894546
95Histidine metabolism_Homo sapiens_hsa003400.71785041
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69630435
97Bile secretion_Homo sapiens_hsa049760.69475747
98Gastric acid secretion_Homo sapiens_hsa049710.69142548
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68365071
100Sulfur metabolism_Homo sapiens_hsa009200.66398641
101Retinol metabolism_Homo sapiens_hsa008300.66176515
102Non-small cell lung cancer_Homo sapiens_hsa052230.65481274
103FoxO signaling pathway_Homo sapiens_hsa040680.65467729
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64933798
105African trypanosomiasis_Homo sapiens_hsa051430.64682704
106Fatty acid elongation_Homo sapiens_hsa000620.62893130
107Melanogenesis_Homo sapiens_hsa049160.62641387
108Prolactin signaling pathway_Homo sapiens_hsa049170.61778338
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61600353
110Regulation of autophagy_Homo sapiens_hsa041400.61458457
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.60278956
112Tryptophan metabolism_Homo sapiens_hsa003800.59921563
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59415198
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59243354
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59151734
116Oxytocin signaling pathway_Homo sapiens_hsa049210.59121292
117Type I diabetes mellitus_Homo sapiens_hsa049400.59025350
118Malaria_Homo sapiens_hsa051440.58979203
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58955212
120Dilated cardiomyopathy_Homo sapiens_hsa054140.58836284
121Hippo signaling pathway_Homo sapiens_hsa043900.58651952
122Mineral absorption_Homo sapiens_hsa049780.58485808
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57387370
124Basal cell carcinoma_Homo sapiens_hsa052170.56565054
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55838552
126Estrogen signaling pathway_Homo sapiens_hsa049150.55810162
127p53 signaling pathway_Homo sapiens_hsa041150.55306158
128Steroid biosynthesis_Homo sapiens_hsa001000.55236208
129N-Glycan biosynthesis_Homo sapiens_hsa005100.54755437
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54488681
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54156347
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52689654
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52470037
134Proteoglycans in cancer_Homo sapiens_hsa052050.52034944
135Wnt signaling pathway_Homo sapiens_hsa043100.51706299
136Cocaine addiction_Homo sapiens_hsa050300.51379194
137Pancreatic cancer_Homo sapiens_hsa052120.51317223
138Complement and coagulation cascades_Homo sapiens_hsa046100.51266699
139Pancreatic secretion_Homo sapiens_hsa049720.51198494
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51135747
141mRNA surveillance pathway_Homo sapiens_hsa030150.50935183
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50674858
143Glucagon signaling pathway_Homo sapiens_hsa049220.50307879
144GnRH signaling pathway_Homo sapiens_hsa049120.49813273
145Prostate cancer_Homo sapiens_hsa052150.49111185
146Ether lipid metabolism_Homo sapiens_hsa005650.47398928
147ErbB signaling pathway_Homo sapiens_hsa040120.45428509
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45413197
149Synaptic vesicle cycle_Homo sapiens_hsa047210.44924397
150Choline metabolism in cancer_Homo sapiens_hsa052310.44821785
151T cell receptor signaling pathway_Homo sapiens_hsa046600.43347995
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43072868
153NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41853900
154Starch and sucrose metabolism_Homo sapiens_hsa005000.41764538
155Caffeine metabolism_Homo sapiens_hsa002320.40954337
156MAPK signaling pathway_Homo sapiens_hsa040100.39227464
157Ras signaling pathway_Homo sapiens_hsa040140.38877041
158Axon guidance_Homo sapiens_hsa043600.37962726

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