MKNK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.30554750
2regulation of interferon-beta biosynthetic process (GO:0045357)5.27997508
3intestinal cholesterol absorption (GO:0030299)4.79580425
4positive regulation of interferon-alpha production (GO:0032727)4.71429289
5positive regulation by symbiont of host defense response (GO:0052509)4.47476455
6modulation by symbiont of host defense response (GO:0052031)4.47476455
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.47476455
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.47476455
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.47476455
10modulation by symbiont of host immune response (GO:0052553)4.47476455
11macrophage activation involved in immune response (GO:0002281)4.45969267
12regulation of B cell receptor signaling pathway (GO:0050855)4.43677462
13regulation of interferon-alpha production (GO:0032647)4.42361365
14exocrine pancreas development (GO:0031017)4.41251346
15microglial cell activation (GO:0001774)4.29460444
16glycolipid catabolic process (GO:0019377)4.05941866
17immunoglobulin mediated immune response (GO:0016064)4.04662458
18positive regulation of gamma-delta T cell activation (GO:0046645)4.04461991
19protein retention in ER lumen (GO:0006621)4.02246040
20positive regulation of B cell differentiation (GO:0045579)3.96592653
21neutrophil activation involved in immune response (GO:0002283)3.95626715
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.92196769
23detection of other organism (GO:0098543)3.86331638
24detection of bacterium (GO:0016045)3.66787991
25negative regulation of granulocyte differentiation (GO:0030853)3.63968580
26neutrophil mediated immunity (GO:0002446)3.63300755
27response to peptidoglycan (GO:0032494)3.57934616
28positive regulation of interferon-beta production (GO:0032728)3.51882257
29leukocyte aggregation (GO:0070486)3.50954938
30ceramide catabolic process (GO:0046514)3.44848894
31negative regulation of cell killing (GO:0031342)3.44228522
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.44228522
33detection of external biotic stimulus (GO:0098581)3.43129763
34detection of molecule of bacterial origin (GO:0032490)3.42318952
35regulation of myeloid leukocyte mediated immunity (GO:0002886)3.41994029
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.41984351
37G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.40724129
38positive regulation of mast cell activation involved in immune response (GO:0033008)3.39631466
39positive regulation of mast cell degranulation (GO:0043306)3.39631466
40regulation of B cell differentiation (GO:0045577)3.38366343
41purinergic nucleotide receptor signaling pathway (GO:0035590)3.32224757
42digestion (GO:0007586)3.32031953
43leukocyte degranulation (GO:0043299)3.30921666
44response to interleukin-15 (GO:0070672)3.27593657
45mannose metabolic process (GO:0006013)3.26143731
46response to muramyl dipeptide (GO:0032495)3.26059345
47negative regulation of T cell mediated immunity (GO:0002710)3.24315971
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22062694
49macrophage activation (GO:0042116)3.21725553
50negative regulation of leukocyte mediated immunity (GO:0002704)3.18315350
51respiratory burst (GO:0045730)3.17591349
52myeloid cell activation involved in immune response (GO:0002275)3.17044681
53cellular response to interleukin-15 (GO:0071350)3.17023240
54COPI coating of Golgi vesicle (GO:0048205)3.15070765
55Golgi transport vesicle coating (GO:0048200)3.15070765
56positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.14648049
57cellular extravasation (GO:0045123)3.13439595
58positive regulation of heat generation (GO:0031652)3.12236283
59regulation of gamma-delta T cell differentiation (GO:0045586)3.11846103
60B cell receptor signaling pathway (GO:0050853)3.10161475
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.08239519
62I-kappaB phosphorylation (GO:0007252)3.05865970
63positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.05049028
64regulation of leukocyte degranulation (GO:0043300)3.03571258
65regulation of fever generation (GO:0031620)3.01677736
66leukocyte migration involved in inflammatory response (GO:0002523)3.01626954
67detection of biotic stimulus (GO:0009595)3.01546626
68pinocytosis (GO:0006907)3.01192194
69lipopolysaccharide-mediated signaling pathway (GO:0031663)3.01136462
70regulation of antigen processing and presentation (GO:0002577)3.00868130
71negative regulation of innate immune response (GO:0045824)3.00107897
72regulation of T cell mediated cytotoxicity (GO:0001914)2.99252128
73leukotriene biosynthetic process (GO:0019370)2.99085788
74defense response to protozoan (GO:0042832)2.96467281
75antigen processing and presentation via MHC class Ib (GO:0002475)2.96142312
76positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.95663307
77response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93925849
78response to host (GO:0075136)2.93925849
79response to host defenses (GO:0052200)2.93925849
80mitochondrial calcium ion transport (GO:0006851)2.92943217
81negative regulation of bone resorption (GO:0045779)2.90609349
82response to type I interferon (GO:0034340)2.90587547
83regulation of hypersensitivity (GO:0002883)2.88550816
84B cell mediated immunity (GO:0019724)2.88284188
85germinal center formation (GO:0002467)2.87688591
86cellular response to type I interferon (GO:0071357)2.87603037
87type I interferon signaling pathway (GO:0060337)2.87603037
88regulation of gamma-delta T cell activation (GO:0046643)2.86464134
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.86414253
90antigen processing and presentation of endogenous antigen (GO:0019883)2.85761681
91antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84532115
92antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84532115
93regulation of T cell tolerance induction (GO:0002664)2.84124262
94negative thymic T cell selection (GO:0045060)2.80329760
95negative regulation of T-helper cell differentiation (GO:0045623)2.79282748
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.79282748
97negative T cell selection (GO:0043383)2.79013438
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77651975
99negative regulation of alpha-beta T cell activation (GO:0046636)2.76826851
100response to host immune response (GO:0052572)2.76789707
101response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.76789707
102negative regulation of interleukin-6 production (GO:0032715)2.76782192
103neutrophil activation (GO:0042119)2.76741168
104production of molecular mediator involved in inflammatory response (GO:0002532)2.76147649
105regulation of tolerance induction (GO:0002643)2.76103347
106regulation of dendritic cell antigen processing and presentation (GO:0002604)2.75982292
107membrane lipid catabolic process (GO:0046466)2.75833005
108dendritic cell migration (GO:0036336)2.74913258
109response to protozoan (GO:0001562)2.74500559
110valine metabolic process (GO:0006573)2.73429314
111regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.72578128
112leukotriene metabolic process (GO:0006691)2.72140284
113regulation of interferon-beta production (GO:0032648)2.71771388
114negative regulation of interleukin-1 production (GO:0032692)2.71162398
115glycosphingolipid catabolic process (GO:0046479)2.70660746
116granulocyte activation (GO:0036230)2.69745563
117myeloid leukocyte mediated immunity (GO:0002444)2.64149239
118regulation of mast cell degranulation (GO:0043304)2.61224058
119L-alpha-amino acid transmembrane transport (GO:1902475)2.60202009
120purinergic receptor signaling pathway (GO:0035587)2.59883529
121activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.58775699
122regulation of interleukin-12 biosynthetic process (GO:0045075)2.58460825
123JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.58042939
124regulation of mast cell activation involved in immune response (GO:0033006)2.57394346
125positive regulation of antigen processing and presentation (GO:0002579)2.57036174
126positive thymic T cell selection (GO:0045059)2.55600601
127interferon-gamma-mediated signaling pathway (GO:0060333)2.52406761
128phosphatidylglycerol biosynthetic process (GO:0006655)2.51774753
129positive regulation of nuclease activity (GO:0032075)2.51214345
130regulation of erythrocyte differentiation (GO:0045646)2.49046246
131myeloid leukocyte activation (GO:0002274)2.49022816
132positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.48399694
133positive regulation of mast cell activation (GO:0033005)2.47451095
134positive regulation of chemokine biosynthetic process (GO:0045080)2.46786673
135regulation of mast cell activation (GO:0033003)2.43552948
136positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.43248387
137negative regulation of interleukin-12 production (GO:0032695)2.42231886
138neutrophil chemotaxis (GO:0030593)2.41512432
139mast cell activation (GO:0045576)2.40673730
140myeloid dendritic cell activation (GO:0001773)2.40637070
141regulation of response to interferon-gamma (GO:0060330)2.39868008

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.82571794
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.32961282
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.02563395
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.38846580
5* IRF8_27001747_Chip-Seq_BMDM_Mouse3.23199087
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15797358
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85051311
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79648290
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65457832
10GATA1_22025678_ChIP-Seq_K562_Human2.64969054
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60826738
12MYC_22102868_ChIP-Seq_BL_Human2.55712149
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.42237124
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.41561987
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40864200
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.37406648
17* SCL_19346495_ChIP-Seq_HPC-7_Human2.31280050
18VDR_21846776_ChIP-Seq_THP-1_Human2.30152045
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.26493834
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15176643
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05687986
22VDR_24787735_ChIP-Seq_THP-1_Human2.05511596
23SPI1_23547873_ChIP-Seq_NB4_Human2.02029951
24SPI1_23127762_ChIP-Seq_K562_Human2.00599977
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.99215623
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96439297
27MYB_26560356_Chip-Seq_TH2_Human1.95870038
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.91651662
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86487526
30MAF_26560356_Chip-Seq_TH1_Human1.86328977
31* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.86032058
32VDR_24763502_ChIP-Seq_THP-1_Human1.85118203
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81924696
34* RUNX_20019798_ChIP-Seq_JUKART_Human1.79828495
35GATA1_22383799_ChIP-Seq_G1ME_Mouse1.75320077
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72370020
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71858276
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71579195
39* GATA1_19941827_ChIP-Seq_MEL_Mouse1.71540915
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68586610
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.66339030
42* MYB_26560356_Chip-Seq_TH1_Human1.65899330
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65836972
44TCF7_22412390_ChIP-Seq_EML_Mouse1.63725703
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62263154
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61351338
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.60844437
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59037906
49* UTX_26944678_Chip-Seq_JUKART_Human1.57967614
50E2F7_22180533_ChIP-Seq_HELA_Human1.57039408
51GATA1_19941826_ChIP-Seq_K562_Human1.51282852
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49681322
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49104575
54* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49059753
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47519818
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43905120
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41376547
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41098584
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39388560
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.37836810
61PU_27001747_Chip-Seq_BMDM_Mouse1.37704837
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36396345
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36351103
64* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35184635
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.34609506
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30124897
67* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29836589
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.28876296
69GATA3_27048872_Chip-Seq_THYMUS_Human1.28846637
70BCL6_27268052_Chip-Seq_Bcells_Human1.28812648
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27522008
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25829874
73* MAF_26560356_Chip-Seq_TH2_Human1.24489481
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24477990
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.23329819
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.22423589
77KDM2B_26808549_Chip-Seq_DND41_Human1.21103441
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21038064
79GATA2_19941826_ChIP-Seq_K562_Human1.16508523
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16295443
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15299829
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14966098
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11006387
84BCOR_27268052_Chip-Seq_Bcells_Human1.10566645
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10354100
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10229485
87LXR_22292898_ChIP-Seq_THP-1_Human1.09785006
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09059035
89LXR_22158963_ChIP-Seq_LIVER_Mouse1.08756877
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08380459
91STAT1_20625510_ChIP-Seq_HELA_Human1.07119884
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06450324
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05264690
94FOXM1_23109430_ChIP-Seq_U2OS_Human1.04901472
95TFEB_21752829_ChIP-Seq_HELA_Human1.04791941
96GATA3_26560356_Chip-Seq_TH2_Human1.04118626
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03979532
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03854472
99NCOR1_26117541_ChIP-Seq_K562_Human0.98094120
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98016977
101EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97056638
102CLOCK_20551151_ChIP-Seq_293T_Human0.96855830
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94448376
104ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93623234
105CIITA_25753668_ChIP-Seq_RAJI_Human0.93195122
106SMRT_27268052_Chip-Seq_Bcells_Human0.92382770
107SPI1_20517297_ChIP-Seq_HL60_Human0.92050121
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91921163
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90149111
110GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89980296
111STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89675834
112PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88358323
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88240386
114P300_27268052_Chip-Seq_Bcells_Human0.87726729
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85778235
116FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85341450
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84964308
118HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84311022
119RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83611614
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83301910
121ELF1_20517297_ChIP-Seq_JURKAT_Human0.82871877
122FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81669847
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77483832
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77278171
125RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76706766
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75046828
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.73723549
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73521217
129DROSHA_22980978_ChIP-Seq_HELA_Human0.71520239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.44005170
2MP0005058_abnormal_lysosome_morphology3.32196321
3MP0005083_abnormal_biliary_tract3.16151521
4MP0001666_abnormal_nutrient_absorption2.79368276
5MP0003191_abnormal_cellular_cholesterol2.71287157
6MP0006082_CNS_inflammation2.70029931
7MP0005671_abnormal_response_to2.57107983
8MP0005464_abnormal_platelet_physiology2.52592535
9MP0003172_abnormal_lysosome_physiology2.52261536
10MP0003436_decreased_susceptibility_to2.49381139
11MP0002419_abnormal_innate_immunity2.41159878
12MP0003303_peritoneal_inflammation2.31273691
13MP0005000_abnormal_immune_tolerance2.25621473
14MP0001800_abnormal_humoral_immune2.22292728
15MP0000685_abnormal_immune_system2.22124896
16MP0005365_abnormal_bile_salt2.21941434
17MP0009840_abnormal_foam_cell2.17850691
18MP0002452_abnormal_antigen_presenting2.16070176
19MP0003656_abnormal_erythrocyte_physiolo2.14194781
20MP0002723_abnormal_immune_serum2.10421365
21MP0002148_abnormal_hypersensitivity_rea2.08519023
22MP0003300_gastrointestinal_ulcer2.00584570
23MP0002420_abnormal_adaptive_immunity1.97831190
24MP0009785_altered_susceptibility_to1.96848251
25MP0005025_abnormal_response_to1.96642124
26MP0001790_abnormal_immune_system1.96362071
27MP0005387_immune_system_phenotype1.96362071
28MP0001819_abnormal_immune_cell1.95971766
29MP0005220_abnormal_exocrine_pancreas1.94042764
30MP0009333_abnormal_splenocyte_physiolog1.88148851
31MP0001873_stomach_inflammation1.80558644
32MP0002405_respiratory_system_inflammati1.76830425
33MP0001845_abnormal_inflammatory_respons1.76514169
34MP0004510_myositis1.75433181
35MP0003183_abnormal_peptide_metabolism1.74147969
36MP0003195_calcinosis1.72563508
37MP0002396_abnormal_hematopoietic_system1.71166470
38MP0002398_abnormal_bone_marrow1.68971628
39MP0005310_abnormal_salivary_gland1.64984146
40MP0000689_abnormal_spleen_morphology1.60005518
41MP0003828_pulmonary_edema1.57746597
42MP0008469_abnormal_protein_level1.57475592
43MP0000716_abnormal_immune_system1.55166440
44MP0004947_skin_inflammation1.54188026
45MP0003763_abnormal_thymus_physiology1.52624160
46MP0002722_abnormal_immune_system1.47526105
47MP0002006_tumorigenesis1.46269434
48MP0009278_abnormal_bone_marrow1.42799508
49MP0000858_altered_metastatic_potential1.40121315
50MP0001533_abnormal_skeleton_physiology1.39078491
51MP0002429_abnormal_blood_cell1.37662270
52MP0010155_abnormal_intestine_physiology1.36622616
53MP0002693_abnormal_pancreas_physiology1.33840668
54MP0005397_hematopoietic_system_phenotyp1.29981270
55MP0001545_abnormal_hematopoietic_system1.29981270
56MP0001853_heart_inflammation1.29372270
57MP0002277_abnormal_respiratory_mucosa1.29023586
58MP0000569_abnormal_digit_pigmentation1.28061503
59MP0003724_increased_susceptibility_to1.27317171
60MP0002166_altered_tumor_susceptibility1.26698474
61MP0000465_gastrointestinal_hemorrhage1.24649857
62MP0003806_abnormal_nucleotide_metabolis1.22780087
63MP0000604_amyloidosis1.20517802
64MP0000490_abnormal_crypts_of1.17192165
65MP0001851_eye_inflammation1.16510987
66MP0000343_altered_response_to1.15394569
67MP0003075_altered_response_to1.13125738
68MP0000609_abnormal_liver_physiology1.12070492
69MP0003252_abnormal_bile_duct1.10946689
70MP0005085_abnormal_gallbladder_physiolo1.08806705
71MP0001986_abnormal_taste_sensitivity1.08583384
72MP0005670_abnormal_white_adipose1.08568254
73MP0005075_abnormal_melanosome_morpholog1.07394219
74MP0004883_abnormal_blood_vessel1.06716768
75MP0003868_abnormal_feces_composition1.06265740
76MP0002998_abnormal_bone_remodeling1.06070598
77MP0004808_abnormal_hematopoietic_stem1.05013306
78MP0009764_decreased_sensitivity_to1.03195662
79MP0000703_abnormal_thymus_morphology1.03166186
80MP0005167_abnormal_blood-brain_barrier0.98828350
81MP0002132_abnormal_respiratory_system0.97470582
82MP0005166_decreased_susceptibility_to0.96842147
83MP0005084_abnormal_gallbladder_morpholo0.95512272
84MP0002928_abnormal_bile_duct0.95442072
85MP0004381_abnormal_hair_follicle0.94481040
86MP0003448_altered_tumor_morphology0.94395986
87MP0005174_abnormal_tail_pigmentation0.93713162
88MP0005164_abnormal_response_to0.93138341
89MP0000598_abnormal_liver_morphology0.92310166
90MP0000015_abnormal_ear_pigmentation0.89404132
91MP0005390_skeleton_phenotype0.89256207
92MP0003705_abnormal_hypodermis_morpholog0.88802962
93MP0003690_abnormal_glial_cell0.87970725
94MP0009763_increased_sensitivity_to0.87822484
95MP0006054_spinal_hemorrhage0.87517478
96MP0001663_abnormal_digestive_system0.85420249
97MP0009643_abnormal_urine_homeostasis0.83479721
98MP0002138_abnormal_hepatobiliary_system0.82493360
99MP0003566_abnormal_cell_adhesion0.82433779
100MP0003045_fibrosis0.81617077
101MP0005319_abnormal_enzyme/_coenzyme0.79780946
102MP0002118_abnormal_lipid_homeostasis0.78938996
103MP0003795_abnormal_bone_structure0.77959553
104MP0001915_intracranial_hemorrhage0.77610625
105MP0005451_abnormal_body_composition0.76911608
106MP0003646_muscle_fatigue0.74617683
107MP0003638_abnormal_response/metabolism_0.73058763
108MP0008260_abnormal_autophagy0.72886100
109MP0003866_abnormal_defecation0.72570411
110MP0010329_abnormal_lipoprotein_level0.71066041
111MP0008004_abnormal_stomach_pH0.69441993
112MP0000249_abnormal_blood_vessel0.69175817
113MP0004130_abnormal_muscle_cell0.68832236
114MP0008438_abnormal_cutaneous_collagen0.68798228
115MP0002933_joint_inflammation0.68541235
116MP0005076_abnormal_cell_differentiation0.68287742
117MP0002136_abnormal_kidney_physiology0.67025912
118MP0002139_abnormal_hepatobiliary_system0.66894113
119MP0009765_abnormal_xenobiotic_induced0.66254446
120MP0003279_aneurysm0.65930350
121MP0002332_abnormal_exercise_endurance0.58898212
122MP0005377_hearing/vestibular/ear_phenot0.55891517
123MP0003878_abnormal_ear_physiology0.55891517
124MP0000920_abnormal_myelination0.54667597
125MP0003329_amyloid_beta_deposits0.54173916

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.44732369
2Systemic lupus erythematosus (HP:0002725)5.43273967
3Recurrent bacterial skin infections (HP:0005406)5.28009426
4Increased cerebral lipofuscin (HP:0011813)4.67547972
5Eczematoid dermatitis (HP:0000976)4.58212867
6Increased neuronal autofluorescent lipopigment (HP:0002074)4.43247418
7Retrobulbar optic neuritis (HP:0100654)4.30779221
8Optic neuritis (HP:0100653)4.30779221
9Abnormality of liposaccharide metabolism (HP:0010968)4.29395694
10Abnormality of glycosphingolipid metabolism (HP:0004343)4.29395694
11Abnormality of glycolipid metabolism (HP:0010969)4.29395694
12Glomerulonephritis (HP:0000099)4.12021565
13Vacuolated lymphocytes (HP:0001922)3.87337644
14Dysostosis multiplex (HP:0000943)3.82780631
15Petechiae (HP:0000967)3.56133501
16Recurrent gram-negative bacterial infections (HP:0005420)3.47435193
17Complement deficiency (HP:0004431)3.33631717
18Gastrointestinal infarctions (HP:0005244)3.29066598
19Recurrent skin infections (HP:0001581)3.26940776
20Hemoptysis (HP:0002105)3.23819671
21Autoimmune thrombocytopenia (HP:0001973)3.23769399
22Encephalitis (HP:0002383)3.15269038
23Recurrent fungal infections (HP:0002841)3.13643413
24Recurrent viral infections (HP:0004429)3.05373560
25Keratoconjunctivitis sicca (HP:0001097)3.03418575
26Periodontitis (HP:0000704)2.99990529
27Impaired platelet aggregation (HP:0003540)2.99653529
28Abnormal platelet function (HP:0011869)2.99653529
29Keratoconjunctivitis (HP:0001096)2.99416346
30Colitis (HP:0002583)2.96059303
31Abnormality of T cell number (HP:0011839)2.94952147
32Mucopolysacchariduria (HP:0008155)2.94732124
33Urinary glycosaminoglycan excretion (HP:0003541)2.94732124
34T lymphocytopenia (HP:0005403)2.93316468
35Pustule (HP:0200039)2.93249260
36Elevated erythrocyte sedimentation rate (HP:0003565)2.88913862
37Abnormality of complement system (HP:0005339)2.88726558
38Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.81685500
39Abnormality of polysaccharide metabolism (HP:0011012)2.79991595
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.79991595
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.79991595
42Mediastinal lymphadenopathy (HP:0100721)2.77647529
43Abnormality of macrophages (HP:0004311)2.73020725
44Myositis (HP:0100614)2.71547934
45Cellulitis (HP:0100658)2.69559758
46Loss of speech (HP:0002371)2.67577813
47Gingivitis (HP:0000230)2.66833226
48Epistaxis (HP:0000421)2.64279379
49Prolonged bleeding time (HP:0003010)2.64049800
50Abnormality of T cells (HP:0002843)2.62153909
51Inflammation of the large intestine (HP:0002037)2.62107168
52Chest pain (HP:0100749)2.61608906
53Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.55859042
54Gastrointestinal inflammation (HP:0004386)2.53923866
55Axonal loss (HP:0003447)2.50678766
56Mutism (HP:0002300)2.49676437
57Increased serum ferritin (HP:0003281)2.48517188
58Anorexia (HP:0002039)2.46584598
59Cheilitis (HP:0100825)2.40196674
60Myocardial infarction (HP:0001658)2.38489028
61Disinhibition (HP:0000734)2.37465127
62Nephritis (HP:0000123)2.37159303
63Recurrent cutaneous fungal infections (HP:0011370)2.36786579
64Chronic mucocutaneous candidiasis (HP:0002728)2.36786579
65Agnosia (HP:0010524)2.36417594
66Pulmonary embolism (HP:0002204)2.32742544
67Hematochezia (HP:0002573)2.31296544
68Retinal atrophy (HP:0001105)2.28340757
69Abnormality of transition element cation homeostasis (HP:0011030)2.28058444
70Hypochromic anemia (HP:0001931)2.27716301
71Abnormality of the pleura (HP:0002103)2.27477161
72Cerebral aneurysm (HP:0004944)2.26614295
73Polyneuropathy (HP:0001271)2.26261474
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.25333012
75Thoracic kyphosis (HP:0002942)2.25012633
76Episodic fever (HP:0001954)2.24762841
77Osteomyelitis (HP:0002754)2.22583147
78Urticaria (HP:0001025)2.20879510
79Interstitial pulmonary disease (HP:0006530)2.20016738
80Increased IgM level (HP:0003496)2.19810901
81Abnormality of the prostate (HP:0008775)2.19067319
82IgM deficiency (HP:0002850)2.15769252
83Progressive neurologic deterioration (HP:0002344)2.15157962
84Striae distensae (HP:0001065)2.15073597
85Spontaneous hematomas (HP:0007420)2.12857963
86Abnormality of eosinophils (HP:0001879)2.12472934
87Gangrene (HP:0100758)2.12177554
88Leukocytosis (HP:0001974)2.12058141
89Hypochromic microcytic anemia (HP:0004840)2.11858216
90Steatorrhea (HP:0002570)2.09083976
91Joint stiffness (HP:0001387)2.09025209
92Orchitis (HP:0100796)2.08999047
93Spondylolisthesis (HP:0003302)2.07774217
94Abnormality of T cell physiology (HP:0011840)2.05836729
95Basal ganglia calcification (HP:0002135)2.05727011
96Amyloidosis (HP:0011034)2.04246504
97Meningitis (HP:0001287)2.04052337
98Chronic obstructive pulmonary disease (HP:0006510)2.03856614
99Obstructive lung disease (HP:0006536)2.03856614
100Vasculitis (HP:0002633)2.03699835
101Vertigo (HP:0002321)2.03437080
102Arterial thrombosis (HP:0004420)2.02031321
103Aortic aneurysm (HP:0004942)2.00898073
104Eosinophilia (HP:0001880)2.00782900
105Thrombocytosis (HP:0001894)1.96795218
106Abnormality of the thoracic spine (HP:0100711)1.95934105
107Joint swelling (HP:0001386)1.95638337
108Abnormality of the endocardium (HP:0004306)1.93565551
109Gingival bleeding (HP:0000225)1.93142025
110Global brain atrophy (HP:0002283)1.92458524
111Decreased subcutaneous fat (HP:0001002)1.91144188
112Abnormality of the pericardium (HP:0001697)1.91044798
113Abnormality of iron homeostasis (HP:0011031)1.90810674
114Fatigue (HP:0012378)1.90437256
115Increased IgE level (HP:0003212)1.90361408
116Pathologic fracture (HP:0002756)1.89177346
117Stomatitis (HP:0010280)1.89017616
118Tetraparesis (HP:0002273)1.88707648
119Abnormality of the intrinsic pathway (HP:0010989)1.88399558
120Poikilocytosis (HP:0004447)1.88302187
121Granulocytopenia (HP:0001913)1.87916113
122Panhypogammaglobulinemia (HP:0003139)1.87508542
123Hepatosplenomegaly (HP:0001433)1.86776373
124Abnormality of the fingertips (HP:0001211)1.85927764
125Chronic diarrhea (HP:0002028)1.85871053
126Arterial tortuosity (HP:0005116)1.85753038
127Personality changes (HP:0000751)1.85302842
128Abnormality of subcutaneous fat tissue (HP:0001001)1.84850491
129Agammaglobulinemia (HP:0004432)1.84125711
130Pulmonary infiltrates (HP:0002113)1.83995886
131Keratitis (HP:0000491)1.83709446
132Menorrhagia (HP:0000132)1.82952656
133Autoimmune hemolytic anemia (HP:0001890)1.82379020
134Purpura (HP:0000979)1.81963897
135Microcytic anemia (HP:0001935)1.81715616
136Hypergammaglobulinemia (HP:0010702)1.80823414
137Abolished electroretinogram (ERG) (HP:0000550)1.78759789
138Increased CSF protein (HP:0002922)1.77594328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.03611633
2TGFBR23.41024309
3MAP4K13.40436216
4TAOK32.85055913
5TRIB32.79147653
6TYK22.65434841
7TBK12.49758442
8ZAP702.38862687
9KIT2.33716377
10PKN22.31177111
11TNK22.22855358
12IRAK32.20493238
13TXK2.18524937
14BCKDK2.17670939
15MAP3K142.08572427
16IRAK42.02824846
17MAP2K32.02588873
18BLK2.01172626
19EEF2K1.98619600
20RIPK41.77351450
21CSF1R1.74497320
22STK101.74438189
23PDK21.68686514
24NEK91.64818794
25JAK31.64263211
26ADRBK21.59897053
27IKBKE1.56283698
28FRK1.54528122
29JAK11.52907117
30EPHB11.47884165
31IKBKB1.42705527
32MAPKAPK31.40304326
33FGR1.38057940
34SYK1.36306146
35MAP3K111.32903825
36IRAK11.28521635
37MAPK151.26580046
38JAK21.26578120
39MARK31.25252092
40FGFR41.24789087
41ACVR1B1.24669536
42GRK71.23815019
43MAP3K101.23272005
44BTK1.21324583
45CSK1.14757372
46HCK1.11448947
47SIK31.10280378
48DAPK21.06481869
49MAP2K61.04546488
50MAP3K31.04462029
51FLT31.04436577
52CHUK1.01130349
53CDC42BPA0.99029287
54LYN0.92492025
55MAPK120.90789060
56TEC0.89401879
57PRKCQ0.89360302
58PTK2B0.89068144
59INSRR0.88830728
60PIK3CG0.87478055
61LCK0.85768140
62BMPR1B0.84848246
63GRK60.84109592
64MOS0.82861289
65ITK0.82049622
66PDK10.81250104
67MAP2K20.81052042
68FES0.80927818
69PIM10.80701433
70TRPM70.80523322
71LRRK20.79469125
72FGFR30.78155724
73SCYL20.77522510
74MAP3K130.73847431
75TTN0.73344231
76PRKD20.72469561
77EPHA30.71606253
78PTK60.71200546
79TLK10.70546701
80PAK40.68555255
81PIM20.68188247
82CDK90.67370261
83MATK0.66432922
84MAP3K70.65701296
85MAPKAPK20.65619560
86SIK20.64912226
87CAMK1D0.64237992
88PRKCH0.64093416
89CAMKK10.61303021
90HIPK20.60734724
91MARK20.60085892
92MAPK110.60017007
93PDPK10.56943666
94ADRBK10.55622871
95CAMKK20.54892547
96KSR20.53407196
97PINK10.52227768
98SGK30.51403729
99CDK60.50691916
100EIF2AK30.50007579
101RIPK10.49976681
102MAP3K60.49838284
103MAPK70.49319644
104GRK10.48878747
105TGFBR10.48857659
106MAP3K80.47675627
107CLK10.47170491
108TESK20.46147281
109RPS6KA20.45036580
110RET0.43715981
111EIF2AK10.42436148
112FYN0.41815246
113CDK80.41610039
114RPS6KA60.41526711
115ABL10.40383203
116CDK40.39943388
117KDR0.39848598
118TAOK10.39264810
119EGFR0.38936026
120PRKAA20.38745372
121RPS6KL10.37095913
122RPS6KC10.37095913
123RPS6KA40.37093986
124BMPR20.35709080
125IGF1R0.35048149
126DYRK1B0.34347402
127PRKCD0.34031961
128STK110.33745055
129MTOR0.33421484
130MAP3K10.32819683
131YES10.31982894
132RAF10.31707465
133CAMK10.30001849
134MAP3K20.29965089
135PRKCZ0.29287946
136PRKD10.29074121
137OXSR10.27463182
138ARAF0.27444936

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.44199971
2Staphylococcus aureus infection_Homo sapiens_hsa051503.25949159
3Pancreatic secretion_Homo sapiens_hsa049722.93628249
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.90344822
5Lysosome_Homo sapiens_hsa041422.76809111
6Leishmaniasis_Homo sapiens_hsa051402.74766979
7Allograft rejection_Homo sapiens_hsa053302.72681035
8Autoimmune thyroid disease_Homo sapiens_hsa053202.53241947
9Osteoclast differentiation_Homo sapiens_hsa043802.47576771
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.47189961
11Asthma_Homo sapiens_hsa053102.29557731
12B cell receptor signaling pathway_Homo sapiens_hsa046622.22369432
13Legionellosis_Homo sapiens_hsa051341.93581501
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.92348668
15Fat digestion and absorption_Homo sapiens_hsa049751.91653505
16Tuberculosis_Homo sapiens_hsa051521.83100558
17Measles_Homo sapiens_hsa051621.77917736
18Antigen processing and presentation_Homo sapiens_hsa046121.76568624
19Pertussis_Homo sapiens_hsa051331.68652454
20Influenza A_Homo sapiens_hsa051641.65436973
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.63022547
22Protein digestion and absorption_Homo sapiens_hsa049741.58512880
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56219005
24Hematopoietic cell lineage_Homo sapiens_hsa046401.49799800
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49511848
26Toxoplasmosis_Homo sapiens_hsa051451.47410178
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42496163
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41342919
29Primary immunodeficiency_Homo sapiens_hsa053401.39535422
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35495749
31Folate biosynthesis_Homo sapiens_hsa007901.33486030
32Pancreatic cancer_Homo sapiens_hsa052121.28300517
33Apoptosis_Homo sapiens_hsa042101.27035322
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23721655
35Graft-versus-host disease_Homo sapiens_hsa053321.22470772
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19158781
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16567987
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15985746
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14106976
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11835009
41Herpes simplex infection_Homo sapiens_hsa051681.11833898
42Collecting duct acid secretion_Homo sapiens_hsa049661.11541375
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10291638
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06944377
45African trypanosomiasis_Homo sapiens_hsa051431.04585799
46Glycerolipid metabolism_Homo sapiens_hsa005611.04016732
47Platelet activation_Homo sapiens_hsa046111.03922641
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.03532772
49Chronic myeloid leukemia_Homo sapiens_hsa052201.03294248
50Hepatitis B_Homo sapiens_hsa051611.01908042
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.00545495
52Prion diseases_Homo sapiens_hsa050200.98995394
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.97408587
54Chemokine signaling pathway_Homo sapiens_hsa040620.96708202
55Caffeine metabolism_Homo sapiens_hsa002320.96638587
56Complement and coagulation cascades_Homo sapiens_hsa046100.95335309
57T cell receptor signaling pathway_Homo sapiens_hsa046600.93928764
58Shigellosis_Homo sapiens_hsa051310.92322132
59Acute myeloid leukemia_Homo sapiens_hsa052210.92320572
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91031727
61Malaria_Homo sapiens_hsa051440.90174744
62Renin-angiotensin system_Homo sapiens_hsa046140.87391457
63Selenocompound metabolism_Homo sapiens_hsa004500.86448004
64TNF signaling pathway_Homo sapiens_hsa046680.85137769
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82603331
66Rheumatoid arthritis_Homo sapiens_hsa053230.79545020
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78538734
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76208817
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75215844
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.73860130
71Hepatitis C_Homo sapiens_hsa051600.72016520
72Ether lipid metabolism_Homo sapiens_hsa005650.70109922
73Phagosome_Homo sapiens_hsa041450.69626051
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69364324
75Insulin resistance_Homo sapiens_hsa049310.67954175
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.66504947
77Epstein-Barr virus infection_Homo sapiens_hsa051690.65341979
78N-Glycan biosynthesis_Homo sapiens_hsa005100.65100803
79ABC transporters_Homo sapiens_hsa020100.62746603
80Arachidonic acid metabolism_Homo sapiens_hsa005900.61870290
81Dorso-ventral axis formation_Homo sapiens_hsa043200.61200114
82Type I diabetes mellitus_Homo sapiens_hsa049400.60101582
83Notch signaling pathway_Homo sapiens_hsa043300.60070612
84Protein export_Homo sapiens_hsa030600.59946512
85Salmonella infection_Homo sapiens_hsa051320.58893682
86Regulation of autophagy_Homo sapiens_hsa041400.58698418
87Non-small cell lung cancer_Homo sapiens_hsa052230.56910748
88Viral myocarditis_Homo sapiens_hsa054160.56128356
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.55423009
90Starch and sucrose metabolism_Homo sapiens_hsa005000.55259842
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54827582
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.54586203
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54564750
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54352868
95VEGF signaling pathway_Homo sapiens_hsa043700.53398065
96Linoleic acid metabolism_Homo sapiens_hsa005910.53027518
97Endocytosis_Homo sapiens_hsa041440.49403107
98Nitrogen metabolism_Homo sapiens_hsa009100.48840914
99p53 signaling pathway_Homo sapiens_hsa041150.48548855
100mTOR signaling pathway_Homo sapiens_hsa041500.43427182
101Viral carcinogenesis_Homo sapiens_hsa052030.42281465
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42220088
103Mineral absorption_Homo sapiens_hsa049780.40856688
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38322297
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38314024
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36977200
107PPAR signaling pathway_Homo sapiens_hsa033200.36615259
108FoxO signaling pathway_Homo sapiens_hsa040680.36592447
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.36522920
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35978926
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35357859
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34781251
113Lysine degradation_Homo sapiens_hsa003100.34475022
114Prolactin signaling pathway_Homo sapiens_hsa049170.34178910
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33483799
116Fructose and mannose metabolism_Homo sapiens_hsa000510.32362409
117One carbon pool by folate_Homo sapiens_hsa006700.31181274
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31172641
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.29979923
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29683900
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.29327350
122Sulfur relay system_Homo sapiens_hsa041220.29206860
123Vitamin digestion and absorption_Homo sapiens_hsa049770.29089073
124* MAPK signaling pathway_Homo sapiens_hsa040100.27197772
125Ovarian steroidogenesis_Homo sapiens_hsa049130.25312460
126Sphingolipid metabolism_Homo sapiens_hsa006000.23400780
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.22841856
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22699355
129Systemic lupus erythematosus_Homo sapiens_hsa053220.22088603
130GnRH signaling pathway_Homo sapiens_hsa049120.18692017
131Amoebiasis_Homo sapiens_hsa051460.18614001
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17719863

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