MKNK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.92073219
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.92073219
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.67030433
4valine metabolic process (GO:0006573)4.66635281
5antigen processing and presentation of endogenous antigen (GO:0019883)4.66411775
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.58834653
7negative regulation of cell killing (GO:0031342)4.58834653
8detection of bacterium (GO:0016045)4.47060339
9positive regulation by symbiont of host defense response (GO:0052509)4.36029353
10modulation by symbiont of host defense response (GO:0052031)4.36029353
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.36029353
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.36029353
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.36029353
14modulation by symbiont of host immune response (GO:0052553)4.36029353
15detection of other organism (GO:0098543)4.31030454
16regulation of gamma-delta T cell differentiation (GO:0045586)4.23687685
17positive regulation of gamma-delta T cell activation (GO:0046645)4.20615401
18low-density lipoprotein particle clearance (GO:0034383)4.09175890
19fatty acid transmembrane transport (GO:1902001)4.03380853
20B cell receptor signaling pathway (GO:0050853)4.02803233
21carnitine shuttle (GO:0006853)4.00876575
22regulation of sequestering of triglyceride (GO:0010889)4.00399568
23positive regulation of histone deacetylation (GO:0031065)3.99427941
24regulation of B cell receptor signaling pathway (GO:0050855)3.90339590
25regulation of gamma-delta T cell activation (GO:0046643)3.75442288
26positive regulation of fatty acid beta-oxidation (GO:0032000)3.61187222
27regulation of fatty acid beta-oxidation (GO:0031998)3.57403015
28regulation of interferon-beta biosynthetic process (GO:0045357)3.54106475
29regulation of cholesterol storage (GO:0010885)3.53054967
30germinal center formation (GO:0002467)3.51238624
312-oxoglutarate metabolic process (GO:0006103)3.49730212
32positive thymic T cell selection (GO:0045059)3.44357133
33response to muramyl dipeptide (GO:0032495)3.43868213
34negative regulation of necroptotic process (GO:0060546)3.43605141
353-UTR-mediated mRNA stabilization (GO:0070935)3.41829161
36regulation of necroptotic process (GO:0060544)3.38633231
37CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.35390663
38macrophage activation involved in immune response (GO:0002281)3.32899503
39regulation of fatty acid oxidation (GO:0046320)3.32381908
40detection of external biotic stimulus (GO:0098581)3.28973405
41tricarboxylic acid metabolic process (GO:0072350)3.25526315
42response to type I interferon (GO:0034340)3.23002297
43negative regulation of phagocytosis (GO:0050765)3.22652921
44type I interferon signaling pathway (GO:0060337)3.21471643
45cellular response to type I interferon (GO:0071357)3.21471643
46oxaloacetate metabolic process (GO:0006107)3.20200423
47NIK/NF-kappaB signaling (GO:0038061)3.18922138
48B cell homeostasis (GO:0001782)3.18101206
49positive regulation of fatty acid oxidation (GO:0046321)3.16651382
50immunoglobulin mediated immune response (GO:0016064)3.16074869
51fatty acid beta-oxidation (GO:0006635)3.14353113
52positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.14351183
53response to peptidoglycan (GO:0032494)3.13225971
54carnitine transmembrane transport (GO:1902603)3.13178314
55positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.12698437
56fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.07494915
57biotin metabolic process (GO:0006768)3.04483296
58negative regulation of toll-like receptor signaling pathway (GO:0034122)3.03177215
59lysine catabolic process (GO:0006554)3.02139775
60lysine metabolic process (GO:0006553)3.02139775
61growth hormone receptor signaling pathway (GO:0060396)3.01436159
62positive regulation of protein deacetylation (GO:0090312)3.01154504
63alpha-linolenic acid metabolic process (GO:0036109)3.00243940
64pentose-phosphate shunt (GO:0006098)2.99915219
65negative regulation of erythrocyte differentiation (GO:0045647)2.99050523
66positive regulation of lipid storage (GO:0010884)2.99019499
67carnitine transport (GO:0015879)2.95749114
68amino-acid betaine transport (GO:0015838)2.95749114
69JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.95462675
70response to host immune response (GO:0052572)2.92163931
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.92163931
72response to host (GO:0075136)2.90530131
73response to host defenses (GO:0052200)2.90530131
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90530131
75response to interleukin-15 (GO:0070672)2.87223485
76negative regulation of lymphocyte mediated immunity (GO:0002707)2.86738480
77acetyl-CoA metabolic process (GO:0006084)2.86599649
78thymic T cell selection (GO:0045061)2.85638444
79interferon-gamma-mediated signaling pathway (GO:0060333)2.84700337
80regulation of triglyceride catabolic process (GO:0010896)2.83271922
81negative regulation of granulocyte differentiation (GO:0030853)2.83265078
82triglyceride catabolic process (GO:0019433)2.82498218
83fatty acid oxidation (GO:0019395)2.82207847
84positive regulation of Cdc42 GTPase activity (GO:0043089)2.82178956
85positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.80619314
86leukocyte aggregation (GO:0070486)2.79106480
87detection of biotic stimulus (GO:0009595)2.78715398
88mannose metabolic process (GO:0006013)2.75193193
89lipid oxidation (GO:0034440)2.73907348
90regulation of necrotic cell death (GO:0010939)2.73861007
91regulation of interleukin-12 biosynthetic process (GO:0045075)2.72784804
92activation of MAPKKK activity (GO:0000185)2.69621593
93lymphocyte homeostasis (GO:0002260)2.69312163
94regulation of B cell differentiation (GO:0045577)2.68515747
95regulation of cholesterol homeostasis (GO:2000188)2.67983912
96negative regulation of leukocyte mediated immunity (GO:0002704)2.67969457
97NADPH regeneration (GO:0006740)2.67466935
98positive regulation of B cell differentiation (GO:0045579)2.64396800
99modulation by symbiont of host cellular process (GO:0044068)2.63570580
100positive regulation of lipid catabolic process (GO:0050996)2.62699474
101histone H3-K36 demethylation (GO:0070544)2.62290971
102negative regulation of necrotic cell death (GO:0060547)2.61195373
103muscle filament sliding (GO:0030049)2.61073828
104actin-myosin filament sliding (GO:0033275)2.61073828
105positive regulation of triglyceride metabolic process (GO:0090208)2.60383890
106maternal placenta development (GO:0001893)2.59854079
107brown fat cell differentiation (GO:0050873)2.58691214
108complement activation, alternative pathway (GO:0006957)2.58404036
109positive regulation of Rap GTPase activity (GO:0032854)2.58257668
110T cell migration (GO:0072678)2.58009460
111fatty acid catabolic process (GO:0009062)2.57798302
112branched-chain amino acid metabolic process (GO:0009081)2.57458193
113regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.57455230
114natural killer cell differentiation (GO:0001779)2.57046865
115cellular response to growth hormone stimulus (GO:0071378)2.56552724
116regulation of type I interferon-mediated signaling pathway (GO:0060338)2.55287752
117regulation of dendritic cell antigen processing and presentation (GO:0002604)2.55259001
118neutral lipid catabolic process (GO:0046461)2.51651237
119acylglycerol catabolic process (GO:0046464)2.51651237
120positive regulation of interferon-alpha production (GO:0032727)2.51174829
121negative regulation of cell size (GO:0045792)2.51141138
122regulation of triglyceride biosynthetic process (GO:0010866)2.51038202
123cellular response to zinc ion (GO:0071294)2.50813369
124fatty acid homeostasis (GO:0055089)2.50428938
125regulation of response to interferon-gamma (GO:0060330)2.50105402
126positive regulation of natural killer cell differentiation (GO:0032825)2.49707593
127negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.49292692
128negative thymic T cell selection (GO:0045060)2.49265753
129negative regulation of innate immune response (GO:0045824)2.49101269
130positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48905302
131negative regulation of T cell mediated immunity (GO:0002710)2.48804302
132negative T cell selection (GO:0043383)2.47721405
133T-helper 1 type immune response (GO:0042088)2.47680643
134myeloid dendritic cell differentiation (GO:0043011)2.46813784
135protein localization to endosome (GO:0036010)2.46128302
136regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.45878968
137cellular response to virus (GO:0098586)2.45145215
138modulation by virus of host process (GO:0019054)2.44897226
139defense response to protozoan (GO:0042832)2.44025497
140white fat cell differentiation (GO:0050872)2.43813249
141respiratory burst (GO:0045730)2.42786637
142cellular extravasation (GO:0045123)2.42106841
143neutrophil activation involved in immune response (GO:0002283)2.42090684
144tolerance induction (GO:0002507)2.41881261
145positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.41721914
146positive T cell selection (GO:0043368)2.41702229
147regulation of triglyceride metabolic process (GO:0090207)2.40357279
148plasma lipoprotein particle clearance (GO:0034381)2.40149964
149T cell selection (GO:0045058)2.40042573
150intracellular lipid transport (GO:0032365)2.39933035
151megakaryocyte development (GO:0035855)2.39783183
152positive regulation of triglyceride biosynthetic process (GO:0010867)2.38831068
153embryonic process involved in female pregnancy (GO:0060136)2.38788468
154response to laminar fluid shear stress (GO:0034616)2.37802567
155ethanol oxidation (GO:0006069)2.36990945
156focal adhesion assembly (GO:0048041)2.36168798
157cell-substrate adherens junction assembly (GO:0007045)2.36168798
158lipid particle organization (GO:0034389)2.35818579
159positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.35721559
160lipid storage (GO:0019915)2.35416177
161sarcomere organization (GO:0045214)2.35235282
162detection of molecule of bacterial origin (GO:0032490)2.35087289
163carnitine metabolic process (GO:0009437)2.35010926
164phospholipid homeostasis (GO:0055091)2.34716948
165negative regulation of cardiac muscle tissue growth (GO:0055022)2.34176317
166negative regulation of heart growth (GO:0061117)2.34176317
167creatine metabolic process (GO:0006600)2.33237238
168tricarboxylic acid cycle (GO:0006099)2.33054752
169morphogenesis of an endothelium (GO:0003159)2.31524782
170endothelial tube morphogenesis (GO:0061154)2.31524782
171quaternary ammonium group transport (GO:0015697)2.31405516
172antigen processing and presentation via MHC class Ib (GO:0002475)2.30362557
173skeletal muscle adaptation (GO:0043501)2.29691409
174NADH metabolic process (GO:0006734)2.26923448
175cellular hyperosmotic response (GO:0071474)2.26152557
176mucosal-associated lymphoid tissue development (GO:0048537)2.24998961
177Peyers patch development (GO:0048541)2.24998961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.18968489
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.47586294
3MYC_22102868_ChIP-Seq_BL_Human3.19440261
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.07521925
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.70074215
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.60537956
7* RXR_22158963_ChIP-Seq_LIVER_Mouse2.60084644
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.56907476
9* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.55991365
10VDR_21846776_ChIP-Seq_THP-1_Human2.53434394
11E2F7_22180533_ChIP-Seq_HELA_Human2.35902255
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.35584567
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.33837679
14* CLOCK_20551151_ChIP-Seq_293T_Human2.27852791
15* TCF7_22412390_ChIP-Seq_EML_Mouse2.15368763
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14064594
17* MAF_26560356_Chip-Seq_TH1_Human2.11740356
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.08274069
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.02743854
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.96086592
21* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95653915
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87013356
23* KDM2B_26808549_Chip-Seq_DND41_Human1.85779715
24UTX_26944678_Chip-Seq_JUKART_Human1.84984512
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83744657
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82352575
27ZNF263_19887448_ChIP-Seq_K562_Human1.79566528
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77495263
29* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75604961
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75520435
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74130474
32* SCL_19346495_ChIP-Seq_HPC-7_Human1.71185958
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68548949
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66539938
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66162874
36* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64522503
37* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.64431982
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63573398
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63129328
40VDR_24763502_ChIP-Seq_THP-1_Human1.62009530
41MYB_26560356_Chip-Seq_TH2_Human1.58741692
42* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58063147
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.56506605
44* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53959031
45* MYB_26560356_Chip-Seq_TH1_Human1.53006126
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52429674
47RUNX_20019798_ChIP-Seq_JUKART_Human1.51969223
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49447018
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46051918
50MAF_26560356_Chip-Seq_TH2_Human1.45100133
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43635585
52* LXR_22292898_ChIP-Seq_THP-1_Human1.43576739
53GATA1_22025678_ChIP-Seq_K562_Human1.43460415
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39941154
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38297469
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38293735
57KDM2B_26808549_Chip-Seq_K562_Human1.38020100
58* RACK7_27058665_Chip-Seq_MCF-7_Human1.37569278
59* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37144642
60* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36893762
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.35970362
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34011696
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.33594497
64* SA1_27219007_Chip-Seq_ERYTHROID_Human1.32330312
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.30570304
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27009424
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26653451
68* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25986240
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25952668
70* NCOR1_26117541_ChIP-Seq_K562_Human1.23987639
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.22650655
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21362455
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21148856
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20575736
75ATF3_27146783_Chip-Seq_COLON_Human1.20523075
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.19978188
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19171429
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.18782534
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18733582
80GATA1_19941826_ChIP-Seq_K562_Human1.18598373
81* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18515298
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18135998
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17141983
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17115286
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.16948307
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.16948307
87* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15446920
88SMC4_20622854_ChIP-Seq_HELA_Human1.14853728
89* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14352419
90* CREB1_26743006_Chip-Seq_LNCaP_Human1.13471160
91SPI1_23127762_ChIP-Seq_K562_Human1.12753259
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.10654955
93* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09986384
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09944941
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07793009
96EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07761723
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07096213
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07037117
99* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07030667
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06818902
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05555655
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04579756
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04079656
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04035199
105FOXO3_23340844_ChIP-Seq_DLD1_Human1.03995026
106SPI1_23547873_ChIP-Seq_NB4_Human1.02999285
107TET1_21451524_ChIP-Seq_MESCs_Mouse1.02477211
108* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02288741
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02258473
110PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02118774
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00316926
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99181551
113GATA3_27048872_Chip-Seq_THYMUS_Human0.98469395
114* RUNX1_27514584_Chip-Seq_MCF-7_Human0.98057364
115* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98038316
116GATA2_19941826_ChIP-Seq_K562_Human0.96003151
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95659955
118* CIITA_25753668_ChIP-Seq_RAJI_Human0.93673812
119BCOR_27268052_Chip-Seq_Bcells_Human0.93172423
120* P68_20966046_ChIP-Seq_HELA_Human0.91068127
121* BCL6_27268052_Chip-Seq_Bcells_Human0.90718916
122CTCF_21964334_Chip-Seq_Bcells_Human0.90695512
123CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89691240
124ELF1_20517297_ChIP-Seq_JURKAT_Human0.89285649
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86097344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.66384665
2MP0005670_abnormal_white_adipose2.93903174
3MP0003705_abnormal_hypodermis_morpholog2.60874561
4MP0005666_abnormal_adipose_tissue2.43259458
5MP0004185_abnormal_adipocyte_glucose2.41503626
6MP0004130_abnormal_muscle_cell2.40101042
7MP0003191_abnormal_cellular_cholesterol2.21246291
8MP0000685_abnormal_immune_system2.11160294
9MP0003300_gastrointestinal_ulcer2.04380200
10MP0008260_abnormal_autophagy2.00576711
11MP0002139_abnormal_hepatobiliary_system2.00239904
12MP0005360_urolithiasis1.92596757
13MP0002837_dystrophic_cardiac_calcinosis1.90147594
14MP0001835_abnormal_antigen_presentation1.80950108
15MP0002166_altered_tumor_susceptibility1.78130982
16MP0005375_adipose_tissue_phenotype1.73532620
17MP0003436_decreased_susceptibility_to1.71018596
18MP0010329_abnormal_lipoprotein_level1.69377364
19MP0003646_muscle_fatigue1.68043947
20MP0003566_abnormal_cell_adhesion1.67708486
21MP0001790_abnormal_immune_system1.66409289
22MP0005387_immune_system_phenotype1.66409289
23MP0009840_abnormal_foam_cell1.65170833
24MP0001800_abnormal_humoral_immune1.63176772
25MP0003763_abnormal_thymus_physiology1.56794015
26MP0003303_peritoneal_inflammation1.53183868
27MP0004381_abnormal_hair_follicle1.50809273
28MP0002971_abnormal_brown_adipose1.48704802
29MP0005365_abnormal_bile_salt1.47806128
30MP0002396_abnormal_hematopoietic_system1.47782894
31MP0000609_abnormal_liver_physiology1.47483064
32MP0010352_gastrointestinal_tract_polyps1.45382895
33MP0004087_abnormal_muscle_fiber1.44281982
34MP0009278_abnormal_bone_marrow1.32784968
35MP0005083_abnormal_biliary_tract1.32487661
36MP0000751_myopathy1.31260440
37MP0008438_abnormal_cutaneous_collagen1.30763227
38MP0004084_abnormal_cardiac_muscle1.29822796
39MP0001545_abnormal_hematopoietic_system1.29360383
40MP0005397_hematopoietic_system_phenotyp1.29360383
41MP0002452_abnormal_antigen_presenting1.28136470
42MP0004947_skin_inflammation1.27177498
43MP0010630_abnormal_cardiac_muscle1.27104466
44MP0000858_altered_metastatic_potential1.26710407
45MP0005330_cardiomyopathy1.24976059
46MP0004808_abnormal_hematopoietic_stem1.24896754
47MP0005464_abnormal_platelet_physiology1.24720333
48MP0001853_heart_inflammation1.24637988
49MP0002398_abnormal_bone_marrow1.24422991
50MP0008961_abnormal_basal_metabolism1.24147302
51MP0009115_abnormal_fat_cell1.22344871
52MP0002138_abnormal_hepatobiliary_system1.22232140
53MP0004510_myositis1.21313133
54MP0003045_fibrosis1.20954246
55MP0003828_pulmonary_edema1.20023166
56MP0005310_abnormal_salivary_gland1.18866161
57MP0005076_abnormal_cell_differentiation1.18634739
58MP0000750_abnormal_muscle_regeneration1.18165913
59MP0002420_abnormal_adaptive_immunity1.17576866
60MP0000749_muscle_degeneration1.17040842
61MP0002148_abnormal_hypersensitivity_rea1.17021477
62MP0000733_abnormal_muscle_development1.16833550
63MP0005000_abnormal_immune_tolerance1.16653853
64MP0005085_abnormal_gallbladder_physiolo1.16114280
65MP0001819_abnormal_immune_cell1.15652953
66MP0001533_abnormal_skeleton_physiology1.15191318
67MP0000689_abnormal_spleen_morphology1.14893619
68MP0005025_abnormal_response_to1.13816790
69MP0002723_abnormal_immune_serum1.13804038
70MP0004264_abnormal_extraembryonic_tissu1.13467526
71MP0010155_abnormal_intestine_physiology1.13321409
72MP0002006_tumorigenesis1.13091707
73MP0002722_abnormal_immune_system1.12192843
74MP0005275_abnormal_skin_tensile1.12034460
75MP0000490_abnormal_crypts_of1.10490289
76MP0002009_preneoplasia1.10454356
77MP0005501_abnormal_skin_physiology1.10271358
78MP0003091_abnormal_cell_migration1.10229525
79MP0003183_abnormal_peptide_metabolism1.08812267
80MP0004036_abnormal_muscle_relaxation1.08804150
81MP0010234_abnormal_vibrissa_follicle1.08329982
82MP0001873_stomach_inflammation1.08306105
83MP0000716_abnormal_immune_system1.06045007
84MP0003252_abnormal_bile_duct1.05472287
85MP0002118_abnormal_lipid_homeostasis1.05232785
86MP0002405_respiratory_system_inflammati1.04545563
87MP0005334_abnormal_fat_pad1.04467397
88MP0002970_abnormal_white_adipose1.03840696
89MP0004858_abnormal_nervous_system1.03729552
90MP0004145_abnormal_muscle_electrophysio1.03314814
91MP0000759_abnormal_skeletal_muscle1.03122422
92MP0009785_altered_susceptibility_to1.02353217
93MP0003866_abnormal_defecation1.01904832
94MP0002877_abnormal_melanocyte_morpholog1.01745285
95MP0000003_abnormal_adipose_tissue1.00955213
96MP0003221_abnormal_cardiomyocyte_apopto1.00773280
97MP0005319_abnormal_enzyme/_coenzyme1.00279489
98MP0005385_cardiovascular_system_phenoty0.99860744
99MP0001544_abnormal_cardiovascular_syste0.99860744
100MP0001851_eye_inflammation0.99809963
101MP0005671_abnormal_response_to0.97908519
102MP0008875_abnormal_xenobiotic_pharmacok0.97794630
103MP0001348_abnormal_lacrimal_gland0.97623660
104MP0002106_abnormal_muscle_physiology0.96629228
105MP0002429_abnormal_blood_cell0.96504601
106MP0002998_abnormal_bone_remodeling0.96343063
107MP0000747_muscle_weakness0.95014109
108MP0005023_abnormal_wound_healing0.94325121
109MP0002132_abnormal_respiratory_system0.94170489
110MP0002796_impaired_skin_barrier0.93867472
111MP0001845_abnormal_inflammatory_respons0.93860293
112MP0002419_abnormal_innate_immunity0.93691007
113MP0009333_abnormal_splenocyte_physiolog0.93231368
114MP0003656_abnormal_erythrocyte_physiolo0.92874032
115MP0004233_abnormal_muscle_weight0.92227655
116MP0002254_reproductive_system_inflammat0.91917712
117MP0000343_altered_response_to0.91709128
118MP0000703_abnormal_thymus_morphology0.91666988
119MP0003453_abnormal_keratinocyte_physiol0.91488803
120MP0003724_increased_susceptibility_to0.90766212
121MP0006036_abnormal_mitochondrial_physio0.90448302
122MP0005058_abnormal_lysosome_morphology0.90222061
123MP0008469_abnormal_protein_level0.89678686
124MP0002269_muscular_atrophy0.89162757
125MP0000598_abnormal_liver_morphology0.88842508
126MP0003172_abnormal_lysosome_physiology0.88169319
127MP0009931_abnormal_skin_appearance0.85927245
128MP0005409_darkened_coat_color0.83692171

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)3.59032270
2Increased connective tissue (HP:0009025)3.53639366
3Centrally nucleated skeletal muscle fibers (HP:0003687)3.47093777
4Type 1 muscle fiber predominance (HP:0003803)3.38402483
5Hyporeflexia of lower limbs (HP:0002600)3.23214807
6Meningitis (HP:0001287)3.19663588
7Rhabdomyolysis (HP:0003201)3.17688882
8Recurrent bacterial skin infections (HP:0005406)3.14884567
9Exercise-induced myalgia (HP:0003738)3.13782010
10Exercise-induced muscle cramps (HP:0003710)3.01624867
11Recurrent abscess formation (HP:0002722)2.99372673
12Muscle fiber inclusion bodies (HP:0100299)2.99003991
13Difficulty running (HP:0009046)2.96514350
14Abnormality of macrophages (HP:0004311)2.94418499
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.89023377
16Vasculitis (HP:0002633)2.83408543
17Mediastinal lymphadenopathy (HP:0100721)2.82533692
18Distal lower limb muscle weakness (HP:0009053)2.81094570
19Muscle fiber splitting (HP:0003555)2.79093650
20Verrucae (HP:0200043)2.78673529
21Papilloma (HP:0012740)2.78673529
22Myocardial infarction (HP:0001658)2.73172670
23Gastrointestinal infarctions (HP:0005244)2.71976970
24Distal lower limb amyotrophy (HP:0008944)2.69831642
25Polycythemia (HP:0001901)2.64517334
26Recurrent gram-negative bacterial infections (HP:0005420)2.63886323
27Abnormality of the nasal mucosa (HP:0000433)2.58703515
28Nemaline bodies (HP:0003798)2.56887401
29Deep venous thrombosis (HP:0002625)2.56699439
30Recurrent sinusitis (HP:0011108)2.56285717
31Ventricular tachycardia (HP:0004756)2.55222231
32Autoimmune thrombocytopenia (HP:0001973)2.54131450
33Lymphopenia (HP:0001888)2.53287929
34Right ventricular cardiomyopathy (HP:0011663)2.52030053
35Colitis (HP:0002583)2.50851505
36Nasal polyposis (HP:0100582)2.47778721
37Urticaria (HP:0001025)2.47212898
38Ulnar deviation of the wrist (HP:0003049)2.47018598
39Myositis (HP:0100614)2.44997250
40Osteomyelitis (HP:0002754)2.44553175
41Asymmetric septal hypertrophy (HP:0001670)2.43641473
42Spontaneous hematomas (HP:0007420)2.43060296
43Cellulitis (HP:0100658)2.42027465
44Abnormality of cells of the lymphoid lineage (HP:0012140)2.41758756
45Hypertriglyceridemia (HP:0002155)2.41624879
46Complement deficiency (HP:0004431)2.40659570
47Abnormality of fatty-acid metabolism (HP:0004359)2.40009166
48Cerebral aneurysm (HP:0004944)2.39270642
49Orchitis (HP:0100796)2.38153911
50Chronic obstructive pulmonary disease (HP:0006510)2.34894035
51Obstructive lung disease (HP:0006536)2.34894035
52Gastrointestinal inflammation (HP:0004386)2.33366431
53Facial diplegia (HP:0001349)2.33150155
54Inflammation of the large intestine (HP:0002037)2.32906764
55Restrictive lung disease (HP:0002091)2.31412235
56Xanthomatosis (HP:0000991)2.31371273
57Recurrent viral infections (HP:0004429)2.30776376
58Gingivitis (HP:0000230)2.27143287
59Abnormal platelet volume (HP:0011876)2.25749387
60Hyperglycinuria (HP:0003108)2.25366979
61Abnormality of nail color (HP:0100643)2.23793805
62Frequent falls (HP:0002359)2.23318164
63Abnormality of the fingertips (HP:0001211)2.22038315
64Increased IgE level (HP:0003212)2.20601578
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.20238080
66Recurrent skin infections (HP:0001581)2.19835361
67Chest pain (HP:0100749)2.19616066
68Abnormality of skeletal muscle fiber size (HP:0012084)2.19287904
69Recurrent bronchitis (HP:0002837)2.17682460
70Segmental peripheral demyelination/remyelination (HP:0003481)2.13945397
71Lipoatrophy (HP:0100578)2.13322313
72Conjunctival hamartoma (HP:0100780)2.13050289
73Hyperammonemia (HP:0001987)2.13046441
74Hypochromic anemia (HP:0001931)2.12494238
75Eczematoid dermatitis (HP:0000976)2.11220596
76Fatigue (HP:0012378)2.10519143
77Sudden death (HP:0001699)2.10079469
78Easy fatigability (HP:0003388)2.09394896
79Increased mean platelet volume (HP:0011877)2.09361535
80Hematochezia (HP:0002573)2.08296790
81Hypoglycemic coma (HP:0001325)2.07199159
82Recurrent fungal infections (HP:0002841)2.06457669
83Abnormal platelet function (HP:0011869)2.06380845
84Impaired platelet aggregation (HP:0003540)2.06380845
85Chronic mucocutaneous candidiasis (HP:0002728)2.06166762
86Recurrent cutaneous fungal infections (HP:0011370)2.06166762
87Subaortic stenosis (HP:0001682)2.05826393
88Abnormality of the left ventricular outflow tract (HP:0011103)2.05826393
89Ketosis (HP:0001946)2.04956451
90Acanthosis nigricans (HP:0000956)2.04370321
91IgM deficiency (HP:0002850)2.02974323
92Agammaglobulinemia (HP:0004432)2.02766758
93Hypertensive crisis (HP:0100735)2.01943338
94Abnormality of complement system (HP:0005339)2.01429522
95Pustule (HP:0200039)2.01403493
96Prolonged bleeding time (HP:0003010)2.01306725
97Increased variability in muscle fiber diameter (HP:0003557)2.00671329
98Multiple enchondromatosis (HP:0005701)1.99929736
99Hypoalphalipoproteinemia (HP:0003233)1.99522980
100Chronic otitis media (HP:0000389)1.98312068
101Neck muscle weakness (HP:0000467)1.97806862
102EMG: myopathic abnormalities (HP:0003458)1.97160718
103Increased density of long bones (HP:0006392)1.96968481
104Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.96872042
105Distal arthrogryposis (HP:0005684)1.95607841
106Optic neuritis (HP:0100653)1.95534760
107Retrobulbar optic neuritis (HP:0100654)1.95534760
108Myopathic facies (HP:0002058)1.95227973
109Encephalitis (HP:0002383)1.94992941
110Calf muscle hypertrophy (HP:0008981)1.94106233
111Obstructive sleep apnea (HP:0002870)1.93930375
112Difficulty climbing stairs (HP:0003551)1.92769784
113Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92470814
114Aortic aneurysm (HP:0004942)1.92164825
115Round ear (HP:0100830)1.92013663
116Viral hepatitis (HP:0006562)1.91761705
117Muscle stiffness (HP:0003552)1.87379884
118T lymphocytopenia (HP:0005403)1.87186732
119Panhypogammaglobulinemia (HP:0003139)1.86579165
120Hemorrhage of the eye (HP:0011885)1.86424922
121Skin ulcer (HP:0200042)1.86192272
122Reticulocytosis (HP:0001923)1.84559603
123Slender build (HP:0001533)1.84551778
124Esophageal varix (HP:0002040)1.84190100
125Abnormality of glycine metabolism (HP:0010895)1.84183684
126Abnormality of serine family amino acid metabolism (HP:0010894)1.84183684
127Bulbar palsy (HP:0001283)1.83685576
128Sepsis (HP:0100806)1.82825905
129Hyperlipoproteinemia (HP:0010980)1.82550711
130Pulmonary infiltrates (HP:0002113)1.82181638
131Mildly elevated creatine phosphokinase (HP:0008180)1.81966357
132Keratoconjunctivitis sicca (HP:0001097)1.81837947
133Abnormality of T cell number (HP:0011839)1.80050840
134Abnormality of T cell physiology (HP:0011840)1.79955439
135Abnormal gallbladder physiology (HP:0012438)1.79824664
136Cholecystitis (HP:0001082)1.79824664
137Gastrointestinal stroma tumor (HP:0100723)1.78707512
138Skin rash (HP:0000988)1.77966747
139Abnormality of T cells (HP:0002843)1.77708800
140Slow saccadic eye movements (HP:0000514)1.77092946
141Elevated erythrocyte sedimentation rate (HP:0003565)1.75938051
142Interstitial pulmonary disease (HP:0006530)1.75842906
143Emphysema (HP:0002097)1.75173432
144Spastic diplegia (HP:0001264)1.73540143
145Aneurysm (HP:0002617)1.73500689
146Malnutrition (HP:0004395)1.73365180
147Recurrent lower respiratory tract infections (HP:0002783)1.72273290
148Muscle hypertrophy of the lower extremities (HP:0008968)1.72210966
149Oligomenorrhea (HP:0000876)1.71846738
150IgA deficiency (HP:0002720)1.71722020
151Thrombocytosis (HP:0001894)1.71051741
152Ketoacidosis (HP:0001993)1.70954820
153Epistaxis (HP:0000421)1.70433488
154Rectal prolapse (HP:0002035)1.70344466
155Atrioventricular block (HP:0001678)1.68852603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.03182432
2PRPF4B4.39816426
3PKN23.64504472
4EEF2K3.44598060
5MAP4K13.31682050
6RIPK43.21685998
7MAP3K102.95535025
8TTN2.85571650
9ERN12.81585980
10SMG12.71697582
11SIK12.10616603
12MAP2K32.03507653
13FGFR41.97694657
14IRAK41.97416457
15MAP3K131.94655913
16JAK31.78645952
17BCKDK1.77591561
18LRRK21.76668766
19TYK21.74472774
20CAMK1D1.72871011
21STK101.69470047
22PTK61.57560181
23RIPK11.56973187
24GRK61.52250297
25TGFBR21.50320432
26CDK121.49112677
27EPHB11.46881047
28JAK11.43354765
29TAOK21.38244731
30ZAP701.35272134
31FGFR31.31513852
32FLT31.30457509
33TNK21.26973537
34OBSCN1.25224370
35TBK11.22944524
36MAP3K71.22415370
37MAP3K11.17716360
38KSR21.16306972
39MARK21.14427139
40CAMK1G1.14035698
41BTK1.11755405
42SIK31.05230299
43CDK41.02234312
44PRKD21.01453262
45CDK61.00689799
46CDC42BPA0.99600140
47ITK0.98589741
48MAP3K30.98542802
49PDK30.93021117
50PDK40.93021117
51CSF1R0.92412521
52DMPK0.91576200
53PDPK10.88357552
54CSK0.87392462
55JAK20.86586247
56NEK90.86436063
57MAP3K140.85758137
58PIM10.85168961
59MAPK110.84634800
60HIPK20.84525486
61MST1R0.81895387
62BMX0.81858289
63IKBKE0.81712604
64MAPKAPK30.79385757
65RPS6KB20.79326731
66PRKAA20.76843898
67SYK0.76284983
68RPS6KA40.76067780
69HCK0.75566032
70KDR0.75347293
71TRPM70.74575417
72PDGFRA0.74411806
73STK40.73412519
74TIE10.73020838
75MTOR0.72984498
76CHUK0.70848138
77MAPK70.70559113
78CDK90.70247300
79MAPK120.66960223
80SGK30.66630067
81ILK0.66592209
82NEK20.65755020
83MARK30.64173306
84IKBKB0.63736225
85LYN0.63196889
86FES0.62996815
87FGR0.62213131
88EPHA30.61211695
89IRAK20.61103076
90PIK3CG0.59683983
91BLK0.59662820
92TAOK10.59621453
93ARAF0.58735300
94MAP3K80.58392133
95PRKCH0.58214357
96KIT0.58129803
97LCK0.57244573
98RPS6KA20.57163254
99IRAK10.57002622
100MAP3K110.56998926
101TGFBR10.56843441
102SIK20.55761874
103LMTK20.55435723
104DYRK1B0.55320794
105PAK40.54406695
106MAP3K90.53882774
107EPHA20.53779222
108MAP2K20.53347553
109ICK0.50830088
110MAP3K60.49751010
111PRKD10.49497742
112NME20.48491962
113PDK10.48216234
114MAPK40.47239637
115STK240.47026251
116NLK0.45826299
117IRAK30.45675206
118STK30.45282239
119ALK0.45255388
120PASK0.44415228
121RPS6KA60.43691593
122RET0.43477515
123PDGFRB0.42769970
124TAOK30.42348426
125TEC0.41328849
126RPS6KL10.41211052
127RPS6KC10.41211052
128MAPKAPK20.40584510
129TXK0.40441016
130CLK10.40075669
131RPS6KA10.39931017
132BRAF0.39502203
133YES10.36835113

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000712.61366740
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.57959642
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.53108712
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49353493
5Propanoate metabolism_Homo sapiens_hsa006402.47401404
6Allograft rejection_Homo sapiens_hsa053302.35736395
7PPAR signaling pathway_Homo sapiens_hsa033202.32635512
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.31600668
9Autoimmune thyroid disease_Homo sapiens_hsa053202.23782732
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21521559
11Graft-versus-host disease_Homo sapiens_hsa053322.12138480
12Fatty acid metabolism_Homo sapiens_hsa012122.07102989
13Primary immunodeficiency_Homo sapiens_hsa053401.97109656
14Caffeine metabolism_Homo sapiens_hsa002321.93966229
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68057190
16B cell receptor signaling pathway_Homo sapiens_hsa046621.65339358
17Carbon metabolism_Homo sapiens_hsa012001.64245018
18Staphylococcus aureus infection_Homo sapiens_hsa051501.62709825
19Fatty acid biosynthesis_Homo sapiens_hsa000611.61843236
20Adipocytokine signaling pathway_Homo sapiens_hsa049201.58632066
21Insulin resistance_Homo sapiens_hsa049311.57157328
22Lysine degradation_Homo sapiens_hsa003101.51185508
23Type I diabetes mellitus_Homo sapiens_hsa049401.49798528
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42606139
25Tryptophan metabolism_Homo sapiens_hsa003801.40578742
26Tuberculosis_Homo sapiens_hsa051521.39604934
27Other glycan degradation_Homo sapiens_hsa005111.36996278
28Pyruvate metabolism_Homo sapiens_hsa006201.35738266
29Asthma_Homo sapiens_hsa053101.34076880
30Arginine biosynthesis_Homo sapiens_hsa002201.32977000
31Acute myeloid leukemia_Homo sapiens_hsa052211.32380237
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.30829268
33Viral myocarditis_Homo sapiens_hsa054161.27091991
34Osteoclast differentiation_Homo sapiens_hsa043801.25704236
35Chronic myeloid leukemia_Homo sapiens_hsa052201.24692016
36beta-Alanine metabolism_Homo sapiens_hsa004101.23719422
37Renal cell carcinoma_Homo sapiens_hsa052111.20710718
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20640529
39Nitrogen metabolism_Homo sapiens_hsa009101.18660917
40Complement and coagulation cascades_Homo sapiens_hsa046101.18094594
41Fructose and mannose metabolism_Homo sapiens_hsa000511.16897382
42AMPK signaling pathway_Homo sapiens_hsa041521.16803387
43Leishmaniasis_Homo sapiens_hsa051401.15938416
44Toxoplasmosis_Homo sapiens_hsa051451.15126591
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.12506573
46Glycerolipid metabolism_Homo sapiens_hsa005611.10920170
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.10827526
48Endometrial cancer_Homo sapiens_hsa052131.07397593
49Pentose phosphate pathway_Homo sapiens_hsa000301.06997572
50Measles_Homo sapiens_hsa051621.06008645
51Biosynthesis of amino acids_Homo sapiens_hsa012301.01956307
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.00897889
53Small cell lung cancer_Homo sapiens_hsa052220.99920505
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.99012904
55Starch and sucrose metabolism_Homo sapiens_hsa005000.97844153
56Antigen processing and presentation_Homo sapiens_hsa046120.97451773
57GnRH signaling pathway_Homo sapiens_hsa049120.96614486
58Fat digestion and absorption_Homo sapiens_hsa049750.96018624
59Chemokine signaling pathway_Homo sapiens_hsa040620.94057153
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93001871
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92215234
62Malaria_Homo sapiens_hsa051440.91636895
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.90793588
64Epstein-Barr virus infection_Homo sapiens_hsa051690.90491749
65* Insulin signaling pathway_Homo sapiens_hsa049100.89105382
66T cell receptor signaling pathway_Homo sapiens_hsa046600.88588744
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.87830108
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86847592
69ABC transporters_Homo sapiens_hsa020100.86166819
70Peroxisome_Homo sapiens_hsa041460.85863292
71Phenylalanine metabolism_Homo sapiens_hsa003600.85399786
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83897233
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.83003318
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81998946
75Platelet activation_Homo sapiens_hsa046110.80883425
76Bladder cancer_Homo sapiens_hsa052190.80609451
77Thyroid cancer_Homo sapiens_hsa052160.80381755
78Prostate cancer_Homo sapiens_hsa052150.80157385
79Choline metabolism in cancer_Homo sapiens_hsa052310.79255581
80Hematopoietic cell lineage_Homo sapiens_hsa046400.78665588
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78464036
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78452280
83Non-small cell lung cancer_Homo sapiens_hsa052230.77677469
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77199301
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75444734
86Selenocompound metabolism_Homo sapiens_hsa004500.74000785
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73275386
88Apoptosis_Homo sapiens_hsa042100.72822820
89Sulfur relay system_Homo sapiens_hsa041220.71991954
90Inositol phosphate metabolism_Homo sapiens_hsa005620.71874605
91ErbB signaling pathway_Homo sapiens_hsa040120.70351206
92Pancreatic cancer_Homo sapiens_hsa052120.69781509
93Focal adhesion_Homo sapiens_hsa045100.69318614
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68711154
95Glucagon signaling pathway_Homo sapiens_hsa049220.68442142
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.67184310
97mTOR signaling pathway_Homo sapiens_hsa041500.67158160
98Butanoate metabolism_Homo sapiens_hsa006500.66686131
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66498070
100Glioma_Homo sapiens_hsa052140.65419780
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.65332295
102Shigellosis_Homo sapiens_hsa051310.63632400
103Herpes simplex infection_Homo sapiens_hsa051680.63251587
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61964404
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61493257
106Colorectal cancer_Homo sapiens_hsa052100.61308524
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61306449
108VEGF signaling pathway_Homo sapiens_hsa043700.60883765
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60546818
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.58908177
111* HIF-1 signaling pathway_Homo sapiens_hsa040660.58501581
112Influenza A_Homo sapiens_hsa051640.58366172
113Notch signaling pathway_Homo sapiens_hsa043300.58280168
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.58038679
115Proteoglycans in cancer_Homo sapiens_hsa052050.57870066
116Hepatitis B_Homo sapiens_hsa051610.57087188
117HTLV-I infection_Homo sapiens_hsa051660.56982424
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56675790
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56361021
120Dilated cardiomyopathy_Homo sapiens_hsa054140.56034304
121Legionellosis_Homo sapiens_hsa051340.55588869
122FoxO signaling pathway_Homo sapiens_hsa040680.55382724
123Prolactin signaling pathway_Homo sapiens_hsa049170.55229518
124Galactose metabolism_Homo sapiens_hsa000520.55150459
125Endocytosis_Homo sapiens_hsa041440.53538558
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50072711
127African trypanosomiasis_Homo sapiens_hsa051430.49419230
128TNF signaling pathway_Homo sapiens_hsa046680.49178474
129Bile secretion_Homo sapiens_hsa049760.48478300
130Viral carcinogenesis_Homo sapiens_hsa052030.47935258
131Hepatitis C_Homo sapiens_hsa051600.47675405
132* MAPK signaling pathway_Homo sapiens_hsa040100.45899018
133Adherens junction_Homo sapiens_hsa045200.45316089
134Phagosome_Homo sapiens_hsa041450.45075797
135Type II diabetes mellitus_Homo sapiens_hsa049300.44441367
136Tyrosine metabolism_Homo sapiens_hsa003500.44366649
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43565196
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43221596
139Chemical carcinogenesis_Homo sapiens_hsa052040.43014341
140Prion diseases_Homo sapiens_hsa050200.42817823
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42624296
142Amoebiasis_Homo sapiens_hsa051460.42528763

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