MKRN2OS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aromatic amino acid family catabolic process (GO:0009074)6.04914800
2L-phenylalanine catabolic process (GO:0006559)6.04797467
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.04797467
4tryptophan catabolic process (GO:0006569)5.98666150
5indole-containing compound catabolic process (GO:0042436)5.98666150
6indolalkylamine catabolic process (GO:0046218)5.98666150
7bile acid and bile salt transport (GO:0015721)5.98300711
8L-phenylalanine metabolic process (GO:0006558)5.72844590
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.72844590
10tryptophan metabolic process (GO:0006568)5.57390238
11ketone body metabolic process (GO:1902224)5.48274015
12synapsis (GO:0007129)5.38903034
13kynurenine metabolic process (GO:0070189)5.20859796
14homocysteine metabolic process (GO:0050667)5.20606837
15pyrimidine-containing compound transmembrane transport (GO:0072531)5.15025013
16intestinal cholesterol absorption (GO:0030299)5.13319048
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.11508537
18regulation of bile acid biosynthetic process (GO:0070857)4.97374318
19behavioral response to nicotine (GO:0035095)4.93332818
20phospholipid efflux (GO:0033700)4.80347778
21high-density lipoprotein particle remodeling (GO:0034375)4.63041880
22indolalkylamine metabolic process (GO:0006586)4.59963454
23intestinal absorption (GO:0050892)4.59423304
24aromatic amino acid family metabolic process (GO:0009072)4.55914642
25urea cycle (GO:0000050)4.48811584
26urea metabolic process (GO:0019627)4.48811584
27regulation of cholesterol esterification (GO:0010872)4.47165831
28cellular biogenic amine catabolic process (GO:0042402)4.45776348
29amine catabolic process (GO:0009310)4.45776348
30vitamin transmembrane transport (GO:0035461)4.34882369
31sulfur amino acid catabolic process (GO:0000098)4.33497953
32axoneme assembly (GO:0035082)4.23264936
33regulation of triglyceride catabolic process (GO:0010896)4.22967783
34cysteine metabolic process (GO:0006534)4.22083644
35serine family amino acid catabolic process (GO:0009071)4.18752158
36bile acid biosynthetic process (GO:0006699)4.18240738
37L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.15265735
38bile acid metabolic process (GO:0008206)4.13730026
39drug catabolic process (GO:0042737)4.13703933
40reverse cholesterol transport (GO:0043691)4.10543890
41nitrogen cycle metabolic process (GO:0071941)4.07809400
42triglyceride homeostasis (GO:0070328)4.04406156
43acylglycerol homeostasis (GO:0055090)4.04406156
44protein-lipid complex remodeling (GO:0034368)4.00634974
45macromolecular complex remodeling (GO:0034367)4.00634974
46plasma lipoprotein particle remodeling (GO:0034369)4.00634974
47drug transmembrane transport (GO:0006855)3.90822983
48NAD biosynthetic process (GO:0009435)3.80730936
49positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.79665964
50photoreceptor cell maintenance (GO:0045494)3.76699182
51tyrosine metabolic process (GO:0006570)3.75525653
52glyoxylate metabolic process (GO:0046487)3.73695222
53cytochrome complex assembly (GO:0017004)3.72071488
54cholesterol efflux (GO:0033344)3.70352373
55amino-acid betaine metabolic process (GO:0006577)3.69804810
56cellular glucuronidation (GO:0052695)3.69122736
57inositol phosphate catabolic process (GO:0071545)3.67591538
58negative regulation of sterol transport (GO:0032372)3.65851973
59negative regulation of cholesterol transport (GO:0032375)3.65851973
60alpha-amino acid catabolic process (GO:1901606)3.63364651
61regulation of hexokinase activity (GO:1903299)3.62374461
62regulation of glucokinase activity (GO:0033131)3.62374461
63rRNA methylation (GO:0031167)3.61015136
64auditory receptor cell stereocilium organization (GO:0060088)3.57371713
65positive regulation of lipoprotein lipase activity (GO:0051006)3.55246680
66positive regulation of triglyceride lipase activity (GO:0061365)3.55246680
67L-methionine salvage (GO:0071267)3.55058791
68L-methionine biosynthetic process (GO:0071265)3.55058791
69amino acid salvage (GO:0043102)3.55058791
70flavonoid metabolic process (GO:0009812)3.53224495
71methionine biosynthetic process (GO:0009086)3.52580810
72complement activation, alternative pathway (GO:0006957)3.50272013
73benzene-containing compound metabolic process (GO:0042537)3.49127558
74coenzyme catabolic process (GO:0009109)3.48994168
75detection of light stimulus involved in sensory perception (GO:0050962)3.48990322
76detection of light stimulus involved in visual perception (GO:0050908)3.48990322
77regulation of fibrinolysis (GO:0051917)3.48659440
78very-low-density lipoprotein particle assembly (GO:0034379)3.48243016
79negative regulation of lipase activity (GO:0060192)3.47657987
80nucleotide transmembrane transport (GO:1901679)3.44693325
81uronic acid metabolic process (GO:0006063)3.42837360
82glucuronate metabolic process (GO:0019585)3.42837360
83peptidyl-glutamic acid carboxylation (GO:0017187)3.42258684
84protein carboxylation (GO:0018214)3.42258684
85auditory receptor cell differentiation (GO:0042491)3.41315593
86cholesterol homeostasis (GO:0042632)3.40375881
87plasma lipoprotein particle assembly (GO:0034377)3.39880883
88negative regulation of DNA-dependent DNA replication (GO:2000104)3.38845802
89response to pheromone (GO:0019236)3.38156181
90aldehyde catabolic process (GO:0046185)3.35671116
91cellular amino acid catabolic process (GO:0009063)3.35332109
92neural tube formation (GO:0001841)3.35243529
93exogenous drug catabolic process (GO:0042738)3.34112389
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.33625231
95sterol homeostasis (GO:0055092)3.32417428
96L-fucose metabolic process (GO:0042354)3.30226974
97L-fucose catabolic process (GO:0042355)3.30226974
98fucose catabolic process (GO:0019317)3.30226974
99regulation of protein activation cascade (GO:2000257)3.29887289
100detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29814303
101regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.28924993
102cornea development in camera-type eye (GO:0061303)3.28597721
103imidazole-containing compound metabolic process (GO:0052803)3.28172952
104negative regulation of dendrite development (GO:2000171)3.27984139
105rRNA modification (GO:0000154)3.24784487
106drug transport (GO:0015893)3.23874316
107piRNA metabolic process (GO:0034587)3.23360152
108negative regulation of fibrinolysis (GO:0051918)3.22134367
109arginine metabolic process (GO:0006525)3.22032565
110nicotinamide nucleotide biosynthetic process (GO:0019359)3.21748907
111pyridine nucleotide biosynthetic process (GO:0019363)3.21748907
112polyol catabolic process (GO:0046174)3.21374136
113lipoprotein metabolic process (GO:0042157)3.18393858
114respiratory chain complex IV assembly (GO:0008535)3.18340869
115low-density lipoprotein particle remodeling (GO:0034374)3.17054456
116cellular ketone body metabolic process (GO:0046950)3.16577283
117drug metabolic process (GO:0017144)3.15911048
118somatic hypermutation of immunoglobulin genes (GO:0016446)3.14925789
119somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14925789
120pseudouridine synthesis (GO:0001522)3.12974305
121regulation of cholesterol metabolic process (GO:0090181)3.12888891
122alkaloid metabolic process (GO:0009820)3.10971883
123methionine metabolic process (GO:0006555)3.09609168
124acute-phase response (GO:0006953)3.08520073
125resolution of meiotic recombination intermediates (GO:0000712)3.08432737
126indole-containing compound metabolic process (GO:0042430)3.08286153
1273-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.07998751
128purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.07998751
129regulation of cilium movement (GO:0003352)3.07967262
130regulation of nuclear cell cycle DNA replication (GO:0033262)3.06419430
131protein complex biogenesis (GO:0070271)3.06112181
132plasma lipoprotein particle organization (GO:0071827)3.06021891
133urate metabolic process (GO:0046415)3.03420462
134serine family amino acid metabolic process (GO:0009069)3.02261047
135reflex (GO:0060004)3.00237505
136regulation of complement activation (GO:0030449)2.99941913
137mannosylation (GO:0097502)2.99463210
138inositol phosphate dephosphorylation (GO:0046855)2.98183458
139phosphorylated carbohydrate dephosphorylation (GO:0046838)2.98183458
140blood coagulation, intrinsic pathway (GO:0007597)2.96678349
141bundle of His cell to Purkinje myocyte communication (GO:0086069)2.95956324
142carboxylic acid catabolic process (GO:0046395)2.95824457
143organic acid catabolic process (GO:0016054)2.95824457
144short-chain fatty acid metabolic process (GO:0046459)2.95464784
145lactate metabolic process (GO:0006089)2.95300112
146pyrimidine nucleoside catabolic process (GO:0046135)2.93126917
147plasma lipoprotein particle clearance (GO:0034381)2.90489453
148regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.82686288
149reciprocal meiotic recombination (GO:0007131)2.81793034
150reciprocal DNA recombination (GO:0035825)2.81793034
151negative regulation of execution phase of apoptosis (GO:1900118)2.81055237
152nonmotile primary cilium assembly (GO:0035058)2.80466506
153RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79954168
154tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79954168
155preassembly of GPI anchor in ER membrane (GO:0016254)2.77401917
156meiotic chromosome segregation (GO:0045132)2.76735867
157acrosome reaction (GO:0007340)2.76098088
158tRNA modification (GO:0006400)2.74742588
159mitochondrial respiratory chain complex assembly (GO:0033108)2.74061451
160epithelial cilium movement (GO:0003351)2.73965837
161peptidyl-histidine modification (GO:0018202)2.71920719
162S-adenosylmethionine metabolic process (GO:0046500)2.71142659
163double-strand break repair via homologous recombination (GO:0000724)2.69951243
164regulation of neurotransmitter uptake (GO:0051580)2.69236644
165recombinational repair (GO:0000725)2.68114705
166male meiosis I (GO:0007141)2.68006722
167righting reflex (GO:0060013)2.67631305
168aspartate family amino acid biosynthetic process (GO:0009067)2.67587670
169regulation of acrosome reaction (GO:0060046)2.65243753
170DNA methylation involved in gamete generation (GO:0043046)2.65014393
171adenosine metabolic process (GO:0046085)2.64275987
172sulfur amino acid biosynthetic process (GO:0000097)2.60160805
173retinal rod cell development (GO:0046548)2.58816623
174protein localization to cilium (GO:0061512)2.56847376
175behavioral response to ethanol (GO:0048149)2.55286109
176cilium organization (GO:0044782)2.54035259
177somite development (GO:0061053)2.52987750
178zinc ion transport (GO:0006829)2.52699580
179tRNA processing (GO:0008033)2.51448350
180inner ear receptor stereocilium organization (GO:0060122)2.48984075
181cilium assembly (GO:0042384)2.48606127
182transcription elongation from RNA polymerase III promoter (GO:0006385)2.46478702
183termination of RNA polymerase III transcription (GO:0006386)2.46478702
184negative regulation of epidermal cell differentiation (GO:0045605)2.45950061
185replication fork processing (GO:0031297)2.45932816
186cellular response to ATP (GO:0071318)2.43942998
187somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.42704746
188somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.42704746
189isotype switching (GO:0045190)2.42704746
190double-strand break repair via nonhomologous end joining (GO:0006303)2.42474194
191non-recombinational repair (GO:0000726)2.42474194
192DNA integration (GO:0015074)2.41651173
193inner ear receptor cell differentiation (GO:0060113)2.40454745
194intraciliary transport (GO:0042073)2.40321294
195cell wall macromolecule catabolic process (GO:0016998)2.39982264
196negative regulation of B cell apoptotic process (GO:0002903)2.38820100
197branched-chain amino acid catabolic process (GO:0009083)2.37581636
198nephron epithelium morphogenesis (GO:0072088)2.37331724
199nephron tubule morphogenesis (GO:0072078)2.37331724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.00917552
2EGR1_23403033_ChIP-Seq_LIVER_Mouse5.88503584
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.23073342
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.58377836
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.52201267
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.15567643
7ZNF274_21170338_ChIP-Seq_K562_Hela4.10386617
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.04735592
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.37978946
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01206950
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.91815386
12FUS_26573619_Chip-Seq_HEK293_Human2.70471567
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.59262185
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54323421
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49329099
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.47659440
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34614150
18HTT_18923047_ChIP-ChIP_STHdh_Human2.22971689
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18136193
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.14021304
21TAF15_26573619_Chip-Seq_HEK293_Human2.12830934
22EWS_26573619_Chip-Seq_HEK293_Human2.12118317
23IGF1R_20145208_ChIP-Seq_DFB_Human2.09794004
24KAP1_22055183_ChIP-Seq_ESCs_Mouse2.04946908
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.04916270
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.01243305
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96449575
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.89257621
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.88394848
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81591281
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80206527
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78851191
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77935333
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.76426292
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75812227
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.68122837
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65854021
38ER_23166858_ChIP-Seq_MCF-7_Human1.64101449
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.63008905
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61256674
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.59712947
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59372841
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.58239199
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53777950
45VDR_23849224_ChIP-Seq_CD4+_Human1.53603543
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53557505
47TP53_22573176_ChIP-Seq_HFKS_Human1.50141641
48GATA4_25053715_ChIP-Seq_YYC3_Human1.44356475
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44060728
50SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42012049
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41274960
52RUNX1_27457419_Chip-Seq_LIVER_Mouse1.39259272
53STAT3_18555785_Chip-Seq_ESCs_Mouse1.38034496
54SUZ12_18555785_Chip-Seq_ESCs_Mouse1.37320557
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36974749
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36024466
57HOXB7_26014856_ChIP-Seq_BT474_Human1.35363757
58STAT1_17558387_ChIP-Seq_HELA_Human1.34489780
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33897895
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.32141136
61ELK1_19687146_ChIP-ChIP_HELA_Human1.32117460
62SOX2_19829295_ChIP-Seq_ESCs_Human1.31198893
63NANOG_19829295_ChIP-Seq_ESCs_Human1.31198893
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30917561
65FOXP3_21729870_ChIP-Seq_TREG_Human1.29949836
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.28579077
67SOX2_20726797_ChIP-Seq_SW620_Human1.28152028
68CDX2_20551321_ChIP-Seq_CACO-2_Human1.27818406
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27812065
70P53_22387025_ChIP-Seq_ESCs_Mouse1.27481939
71ESRRB_18555785_Chip-Seq_ESCs_Mouse1.27424106
72OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26303461
73AR_25329375_ChIP-Seq_VCAP_Human1.25836283
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25765421
75SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.25248314
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24892737
77TCF4_23295773_ChIP-Seq_U87_Human1.24796353
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24653986
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24088690
80ZFX_18555785_Chip-Seq_ESCs_Mouse1.23298151
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22850599
82SMAD1_18555785_Chip-Seq_ESCs_Mouse1.22543428
83OCT4_18555785_Chip-Seq_ESCs_Mouse1.21839817
84EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21535879
85STAT3_23295773_ChIP-Seq_U87_Human1.21482247
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.21456884
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21230366
88CBP_20019798_ChIP-Seq_JUKART_Human1.21230366
89KLF4_18555785_Chip-Seq_ESCs_Mouse1.20862851
90SOX2_18555785_Chip-Seq_ESCs_Mouse1.20645787
91SMAD4_21799915_ChIP-Seq_A2780_Human1.20618315
92TCF4_22108803_ChIP-Seq_LS180_Human1.19737044
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19571883
94MYC_18940864_ChIP-ChIP_HL60_Human1.19208681
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.18620367
96GBX2_23144817_ChIP-Seq_PC3_Human1.17648016
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17378352
98HNF4A_19822575_ChIP-Seq_HepG2_Human1.16774250
99P300_18555785_Chip-Seq_ESCs_Mouse1.16731968
100VDR_22108803_ChIP-Seq_LS180_Human1.16460791
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16342025
102TAL1_26923725_Chip-Seq_HPCs_Mouse1.15111402
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14381289
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14004377
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13458743
106IRF1_19129219_ChIP-ChIP_H3396_Human1.13046881
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12953256
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10862029
109NCOR_22424771_ChIP-Seq_293T_Human1.10469557
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09796202
111TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09364122
112PU1_27457419_Chip-Seq_LIVER_Mouse1.09283168
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.08032836
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.07658535
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07543304
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.07452770
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06848341
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06806668
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05394310
120PIAS1_25552417_ChIP-Seq_VCAP_Human1.04700679
121EZH2_22144423_ChIP-Seq_EOC_Human1.04505072
122CDX2_22108803_ChIP-Seq_LS180_Human1.02860629
123BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.01777886
124CTCF_18555785_Chip-Seq_ESCs_Mouse1.00448739
125GABP_19822575_ChIP-Seq_HepG2_Human0.99945752
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99027502
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98468707
128P300_19829295_ChIP-Seq_ESCs_Human0.97686635
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97617241
130PHF8_20622853_ChIP-Seq_HELA_Human0.96733920
131IRF8_22096565_ChIP-ChIP_GC-B_Human0.95787752
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95329711
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95040137
134FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94525738
135AR_20517297_ChIP-Seq_VCAP_Human0.94337597
136NFYB_21822215_ChIP-Seq_K562_Human0.93698729
137GATA3_21878914_ChIP-Seq_MCF-7_Human0.93492728
138RUNX2_22187159_ChIP-Seq_PCA_Human0.93413702
139MYC_19829295_ChIP-Seq_ESCs_Human0.91355617
140CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91294904
141FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91281890
142GATA1_22025678_ChIP-Seq_K562_Human0.91208393
143DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90765291
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90203550
145TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90017808
146HNFA_21074721_ChIP-Seq_CACO-2_Human0.89996287
147SMAD4_21741376_ChIP-Seq_EPCs_Human0.89812905
148NANOG_20526341_ChIP-Seq_ESCs_Human0.89045879
149ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88033893
150BCAT_22108803_ChIP-Seq_LS180_Human0.87352221
151Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86090824
152FOXA2_19822575_ChIP-Seq_HepG2_Human0.84460906
153GATA6_25053715_ChIP-Seq_YYC3_Human0.83992437
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83591312
155GATA3_21867929_ChIP-Seq_CD8_Mouse0.82631143
156CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82091671
157GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.81787293
158FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81443055
159FOXA1_25329375_ChIP-Seq_VCAP_Human0.81443055
160EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81014534
161NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80856072
162NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80856072
163GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80846059
164AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80545632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.17155104
2MP0005360_urolithiasis6.53306642
3MP0005085_abnormal_gallbladder_physiolo5.71424479
4MP0005365_abnormal_bile_salt4.98560398
5MP0008875_abnormal_xenobiotic_pharmacok4.59684924
6MP0000569_abnormal_digit_pigmentation3.65217874
7MP0003252_abnormal_bile_duct3.49793361
8MP0001666_abnormal_nutrient_absorption3.49431327
9MP0002138_abnormal_hepatobiliary_system2.88085616
10MP0006072_abnormal_retinal_apoptosis2.81058312
11MP0004147_increased_porphyrin_level2.74919038
12MP0004019_abnormal_vitamin_homeostasis2.73455194
13MP0002638_abnormal_pupillary_reflex2.70449303
14MP0010329_abnormal_lipoprotein_level2.61974215
15MP0005551_abnormal_eye_electrophysiolog2.45964581
16MP0005257_abnormal_intraocular_pressure2.43730392
17MP0008877_abnormal_DNA_methylation2.38494389
18MP0003195_calcinosis2.37080123
19MP0003868_abnormal_feces_composition2.35026206
20MP0002876_abnormal_thyroid_physiology2.30795720
21MP0003787_abnormal_imprinting2.29281465
22MP0005174_abnormal_tail_pigmentation2.27087139
23MP0005451_abnormal_body_composition2.24712331
24MP0003806_abnormal_nucleotide_metabolis2.24019936
25MP0002822_catalepsy2.21432606
26MP0002938_white_spotting2.08234795
27MP0009840_abnormal_foam_cell2.06391489
28MP0005332_abnormal_amino_acid2.05220775
29MP0003191_abnormal_cellular_cholesterol2.01012732
30MP0005253_abnormal_eye_physiology1.99965694
31MP0001968_abnormal_touch/_nociception1.99963600
32MP0001764_abnormal_homeostasis1.98140222
33MP0009697_abnormal_copulation1.96906641
34MP0000427_abnormal_hair_cycle1.90263518
35MP0002736_abnormal_nociception_after1.69093007
36MP0002160_abnormal_reproductive_system1.66503071
37MP0002118_abnormal_lipid_homeostasis1.64671336
38MP0008995_early_reproductive_senescence1.63163726
39MP0003878_abnormal_ear_physiology1.63087167
40MP0005377_hearing/vestibular/ear_phenot1.63087167
41MP0008058_abnormal_DNA_repair1.62950127
42MP0000516_abnormal_urinary_system1.62599650
43MP0005367_renal/urinary_system_phenotyp1.62599650
44MP0003136_yellow_coat_color1.62453779
45MP0001984_abnormal_olfaction1.60033284
46MP0005083_abnormal_biliary_tract1.59026919
47MP0001986_abnormal_taste_sensitivity1.54753206
48MP0005084_abnormal_gallbladder_morpholo1.51078094
49MP0001485_abnormal_pinna_reflex1.48942177
50MP0002837_dystrophic_cardiac_calcinosis1.47433261
51MP0009643_abnormal_urine_homeostasis1.44796140
52MP0005670_abnormal_white_adipose1.43662549
53MP0000609_abnormal_liver_physiology1.43119598
54MP0004782_abnormal_surfactant_physiolog1.42151466
55MP0002102_abnormal_ear_morphology1.40783988
56MP0004264_abnormal_extraembryonic_tissu1.38997479
57MP0006276_abnormal_autonomic_nervous1.32385196
58MP0000383_abnormal_hair_follicle1.28897024
59MP0003121_genomic_imprinting1.28834896
60MP0005220_abnormal_exocrine_pancreas1.28790327
61MP0002272_abnormal_nervous_system1.28058302
62MP0004043_abnormal_pH_regulation1.27591643
63MP0005075_abnormal_melanosome_morpholog1.27034699
64MP0005636_abnormal_mineral_homeostasis1.26858133
65MP0003724_increased_susceptibility_to1.25966588
66MP0009745_abnormal_behavioral_response1.21974680
67MP0002735_abnormal_chemical_nociception1.20979573
68MP0001873_stomach_inflammation1.19789494
69MP0003880_abnormal_central_pattern1.19213932
70MP0005319_abnormal_enzyme/_coenzyme1.18784244
71MP0002254_reproductive_system_inflammat1.18121762
72MP0004742_abnormal_vestibular_system1.16353385
73MP0000631_abnormal_neuroendocrine_gland1.15424644
74MP0003718_maternal_effect1.14462387
75MP0005646_abnormal_pituitary_gland1.14436312
76MP0010094_abnormal_chromosome_stability1.13110798
77MP0005379_endocrine/exocrine_gland_phen1.13060821
78MP0002184_abnormal_innervation1.12067051
79MP0010386_abnormal_urinary_bladder1.11172920
80MP0002557_abnormal_social/conspecific_i1.10992557
81MP0000566_synostosis1.10857136
82MP0010678_abnormal_skin_adnexa1.10615697
83MP0002277_abnormal_respiratory_mucosa1.10366853
84MP0002234_abnormal_pharynx_morphology1.06919505
85MP0002653_abnormal_ependyma_morphology1.06348280
86MP0005645_abnormal_hypothalamus_physiol1.06281591
87MP0001502_abnormal_circadian_rhythm1.04837897
88MP0006292_abnormal_olfactory_placode1.04762546
89MP0009046_muscle_twitch1.04692855
90MP0005195_abnormal_posterior_eye1.04603209
91MP0003698_abnormal_male_reproductive1.03426925
92MP0005647_abnormal_sex_gland1.01928339
93MP0009764_decreased_sensitivity_to1.01351027
94MP0000778_abnormal_nervous_system1.00331147
95MP0001664_abnormal_digestion0.99507839
96MP0003186_abnormal_redox_activity0.99295533
97MP0000372_irregular_coat_pigmentation0.98634584
98MP0005389_reproductive_system_phenotype0.98436248
99MP0001905_abnormal_dopamine_level0.97001348
100MP0000538_abnormal_urinary_bladder0.95191278
101MP0002210_abnormal_sex_determination0.94052717
102MP0002734_abnormal_mechanical_nocicepti0.93427371
103MP0003786_premature_aging0.93278047
104MP0004270_analgesia0.91389592
105MP0003879_abnormal_hair_cell0.91247534
106MP0001663_abnormal_digestive_system0.91205826
107MP0008789_abnormal_olfactory_epithelium0.90839082
108MP0003011_delayed_dark_adaptation0.90338705
109MP0009765_abnormal_xenobiotic_induced0.89673347
110MP0002064_seizures0.89015000
111MP0005408_hypopigmentation0.89007437
112MP0005423_abnormal_somatic_nervous0.88547191
113MP0000653_abnormal_sex_gland0.87850795
114MP0005410_abnormal_fertilization0.87844617
115MP0001756_abnormal_urination0.87702041
116MP0001145_abnormal_male_reproductive0.87524836
117MP0004924_abnormal_behavior0.87436307
118MP0005386_behavior/neurological_phenoty0.87436307
119MP0004142_abnormal_muscle_tone0.87198400
120MP0002693_abnormal_pancreas_physiology0.86586961
121MP0004215_abnormal_myocardial_fiber0.85814758
122MP0001486_abnormal_startle_reflex0.85095192
123MP0009379_abnormal_foot_pigmentation0.85049402
124MP0003183_abnormal_peptide_metabolism0.84922190
125MP0009780_abnormal_chondrocyte_physiolo0.84895140
126MP0001929_abnormal_gametogenesis0.84668695
127MP0008872_abnormal_physiological_respon0.83382734
128MP0002078_abnormal_glucose_homeostasis0.82257292
129MP0005381_digestive/alimentary_phenotyp0.81474276
130MP0003122_maternal_imprinting0.80965318
131MP0000647_abnormal_sebaceous_gland0.80325280
132MP0005584_abnormal_enzyme/coenzyme_acti0.80058161
133MP0002572_abnormal_emotion/affect_behav0.79789118
134MP0009642_abnormal_blood_homeostasis0.79748910
135MP0008469_abnormal_protein_level0.79736967
136MP0001324_abnormal_eye_pigmentation0.79096111
137MP0001944_abnormal_pancreas_morphology0.78140308
138MP0005058_abnormal_lysosome_morphology0.77681543
139MP0009785_altered_susceptibility_to0.77107877
140MP0002132_abnormal_respiratory_system0.76795454
141MP0001188_hyperpigmentation0.75993564
142MP0000462_abnormal_digestive_system0.71181007
143MP0004381_abnormal_hair_follicle0.69948696
144MP0002928_abnormal_bile_duct0.67094990
145MP0006036_abnormal_mitochondrial_physio0.66956234
146MP0005448_abnormal_energy_balance0.66593782
147MP0002098_abnormal_vibrissa_morphology0.66244142
148MP0001765_abnormal_ion_homeostasis0.63556239
149MP0008004_abnormal_stomach_pH0.63200077
150MP0003953_abnormal_hormone_level0.62881731
151MP0009763_increased_sensitivity_to0.62377511
152MP0000598_abnormal_liver_morphology0.61264283
153MP0005334_abnormal_fat_pad0.59628930
154MP0000613_abnormal_salivary_gland0.59311161
155MP0001346_abnormal_lacrimal_gland0.59144125
156MP0000678_abnormal_parathyroid_gland0.58574568
157MP0005376_homeostasis/metabolism_phenot0.58154448
158MP0005310_abnormal_salivary_gland0.56492355
159MP0001661_extended_life_span0.56417549
160MP0003866_abnormal_defecation0.56083716
161MP0005535_abnormal_body_temperature0.54961885
162MP0005248_abnormal_Harderian_gland0.54555876
163MP0002163_abnormal_gland_morphology0.51747065
164MP0010155_abnormal_intestine_physiology0.50868978
165MP0000579_abnormal_nail_morphology0.49087942
166MP0000230_abnormal_systemic_arterial0.48422658
167MP0005395_other_phenotype0.47740215
168MP0001845_abnormal_inflammatory_respons0.47362359
169MP0008260_abnormal_autophagy0.45015146
170MP0002136_abnormal_kidney_physiology0.43439326

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.60876946
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.47112928
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.78540896
4Prolonged partial thromboplastin time (HP:0003645)4.73378807
5Hypobetalipoproteinemia (HP:0003563)4.32732171
6Conjugated hyperbilirubinemia (HP:0002908)4.27466823
7Xanthomatosis (HP:0000991)4.19497404
8Congenital stationary night blindness (HP:0007642)4.09889742
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.06819081
10Hyperlipoproteinemia (HP:0010980)4.05182936
11Hypoglycemic coma (HP:0001325)3.95435390
12Malnutrition (HP:0004395)3.94792502
13Decreased central vision (HP:0007663)3.93064699
14Hyperglycinuria (HP:0003108)3.89726259
15Renal cortical cysts (HP:0000803)3.88834262
16Fat malabsorption (HP:0002630)3.82243034
17Hyperglycinemia (HP:0002154)3.80434913
18Pancreatic fibrosis (HP:0100732)3.71380689
19Prostate neoplasm (HP:0100787)3.59038775
20Abnormal rod and cone electroretinograms (HP:0008323)3.58576055
21Hypolipoproteinemia (HP:0010981)3.55941757
22Pancreatic cysts (HP:0001737)3.53749631
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.52246745
24Deep venous thrombosis (HP:0002625)3.51631257
25Pendular nystagmus (HP:0012043)3.42305935
26Intestinal atresia (HP:0011100)3.40804343
27True hermaphroditism (HP:0010459)3.38878177
28Nephronophthisis (HP:0000090)3.38777977
29Joint hemorrhage (HP:0005261)3.32268257
30Abnormality of serine family amino acid metabolism (HP:0010894)3.30795640
31Abnormality of glycine metabolism (HP:0010895)3.30795640
32Hypoalphalipoproteinemia (HP:0003233)3.30346253
33Abnormality of purine metabolism (HP:0004352)3.26563882
34Symptomatic seizures (HP:0011145)3.23238582
35Proximal tubulopathy (HP:0000114)3.21471865
36Abnormality of the intrinsic pathway (HP:0010989)3.20193281
37Absent rod-and cone-mediated responses on ERG (HP:0007688)3.19952499
38Abnormality of midbrain morphology (HP:0002418)3.15294602
39Molar tooth sign on MRI (HP:0002419)3.15294602
40Attenuation of retinal blood vessels (HP:0007843)3.13629536
41Abnormality of nucleobase metabolism (HP:0010932)3.10904831
42Abnormality of aspartate family amino acid metabolism (HP:0010899)3.07980010
43Hypoglycemic seizures (HP:0002173)3.02735453
44Hyperglycemia (HP:0003074)3.00906302
45Oligomenorrhea (HP:0000876)2.95096152
46Severe visual impairment (HP:0001141)2.93873621
47Abnormality of fatty-acid metabolism (HP:0004359)2.93775406
48Hyperammonemia (HP:0001987)2.93175568
49Generalized aminoaciduria (HP:0002909)2.92109727
50Abnormality of sulfur amino acid metabolism (HP:0004339)2.91633752
51Abnormality of the renal medulla (HP:0100957)2.87136045
52Glycosuria (HP:0003076)2.83280239
53Abnormality of urine glucose concentration (HP:0011016)2.83280239
54Complement deficiency (HP:0004431)2.82371880
55Ketosis (HP:0001946)2.81511462
56Type II lissencephaly (HP:0007260)2.81245785
57Abnormality of pyrimidine metabolism (HP:0004353)2.79586729
58Tubulointerstitial nephritis (HP:0001970)2.78419680
59Abnormality of the common coagulation pathway (HP:0010990)2.77528850
60Chronic hepatic failure (HP:0100626)2.76908612
61Increased purine levels (HP:0004368)2.74513349
62Hyperuricemia (HP:0002149)2.74513349
63Rib fusion (HP:0000902)2.73326104
64Abnormality of methionine metabolism (HP:0010901)2.73192863
65Steatorrhea (HP:0002570)2.72918859
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.68484247
67Epidermoid cyst (HP:0200040)2.63751718
68Gaze-evoked nystagmus (HP:0000640)2.63369598
69Ileus (HP:0002595)2.61572463
70Abnormality of proline metabolism (HP:0010907)2.57428310
71Hydroxyprolinuria (HP:0003080)2.57428310
72Hypercholesterolemia (HP:0003124)2.56298969
73Abnormality of macular pigmentation (HP:0008002)2.53116952
74Gout (HP:0001997)2.49505688
75Colon cancer (HP:0003003)2.48396249
76Dicarboxylic aciduria (HP:0003215)2.48122055
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48122055
78Cystic liver disease (HP:0006706)2.47386211
79Hyperbilirubinemia (HP:0002904)2.47138085
80Reduced antithrombin III activity (HP:0001976)2.46296046
81Medial flaring of the eyebrow (HP:0010747)2.44838733
82Tubular atrophy (HP:0000092)2.43023406
83Chorioretinal atrophy (HP:0000533)2.41553426
84Lethargy (HP:0001254)2.40024858
85Abolished electroretinogram (ERG) (HP:0000550)2.39456461
86Bony spicule pigmentary retinopathy (HP:0007737)2.38960033
87Metabolic acidosis (HP:0001942)2.35489485
88Ketoacidosis (HP:0001993)2.35404468
89Abnormality of serum amino acid levels (HP:0003112)2.34649634
90Hyperactive renin-angiotensin system (HP:0000841)2.29197298
91Enlarged kidneys (HP:0000105)2.25414532
92Spontaneous abortion (HP:0005268)2.24960932
93Widely patent fontanelles and sutures (HP:0004492)2.24766800
94Alkalosis (HP:0001948)2.22561961
95Abnormality of the prostate (HP:0008775)2.19982484
96Vascular calcification (HP:0004934)2.17294859
97Hepatocellular necrosis (HP:0001404)2.16937257
98Aplasia/Hypoplasia of the tongue (HP:0010295)2.15528434
99Hyperinsulinemic hypoglycemia (HP:0000825)2.14689287
100Anencephaly (HP:0002323)2.14188082
101Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12413562
102Dyskinesia (HP:0100660)2.11634609
103Increased CSF lactate (HP:0002490)2.10880557
104Gait imbalance (HP:0002141)2.06209742
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04662466
106Abnormal protein N-linked glycosylation (HP:0012347)2.04662466
107Abnormal protein glycosylation (HP:0012346)2.04662466
108Abnormal glycosylation (HP:0012345)2.04662466
109Brushfield spots (HP:0001088)2.02774590
110Occipital encephalocele (HP:0002085)2.01885768
111Cheilitis (HP:0100825)2.01679310
112Congenital primary aphakia (HP:0007707)2.01352958
113Mitochondrial inheritance (HP:0001427)2.01147459
114Abnormality of vitamin metabolism (HP:0100508)1.98395046
115Abnormality of the renal cortex (HP:0011035)1.98162793
116Cerebral edema (HP:0002181)1.98057414
117Right ventricular cardiomyopathy (HP:0011663)1.97805784
118Large for gestational age (HP:0001520)1.97770515
119Pancreatitis (HP:0001733)1.97651260
120Abnormality of the pons (HP:0007361)1.97534721
121Nausea (HP:0002018)1.97402478
122Beaking of vertebral bodies (HP:0004568)1.96841646
123Retinitis pigmentosa (HP:0000510)1.96518644
124Menorrhagia (HP:0000132)1.96137471
125Aqueductal stenosis (HP:0002410)1.95720435
126Male pseudohermaphroditism (HP:0000037)1.95582144
127Abnormal biliary tract physiology (HP:0012439)1.95117473
128Bile duct proliferation (HP:0001408)1.95117473
129Hypoplasia of the pons (HP:0012110)1.94664354
130Congenital sensorineural hearing impairment (HP:0008527)1.93560381
131Postaxial foot polydactyly (HP:0001830)1.90849410
132Acute lymphatic leukemia (HP:0006721)1.90673015
133Rickets (HP:0002748)1.90488865
134Irritability (HP:0000737)1.90126818
135Abnormality of small intestinal villus morphology (HP:0011472)1.89704871
136Villous atrophy (HP:0011473)1.89704871
137Decreased circulating renin level (HP:0003351)1.89312219
138Insulin-resistant diabetes mellitus (HP:0000831)1.88686734
139Genital tract atresia (HP:0001827)1.88565694
140Vacuolated lymphocytes (HP:0001922)1.87693417
141Pustule (HP:0200039)1.86736806
142Abnormality of complement system (HP:0005339)1.86473052
143Nephrogenic diabetes insipidus (HP:0009806)1.86298836
144Optic nerve hypoplasia (HP:0000609)1.85963206
145Gastrointestinal atresia (HP:0002589)1.85652418
146Akinesia (HP:0002304)1.85119133
147Acanthocytosis (HP:0001927)1.83807505
148Alveolar cell carcinoma (HP:0006519)1.83603839
149Type I transferrin isoform profile (HP:0003642)1.82776150
150Congenital hepatic fibrosis (HP:0002612)1.82335826
151Abnormal enzyme/coenzyme activity (HP:0012379)1.82167951
152Sclerocornea (HP:0000647)1.81839651
153Oculomotor apraxia (HP:0000657)1.80805294
154Confusion (HP:0001289)1.80726510
155Furrowed tongue (HP:0000221)1.80346372
156Abnormality of vitamin B metabolism (HP:0004340)1.78277495
157Retinal dysplasia (HP:0007973)1.77329336
158Opisthotonus (HP:0002179)1.75811593
159Postaxial hand polydactyly (HP:0001162)1.75568220
160Vaginal atresia (HP:0000148)1.75521806
161Hepatic necrosis (HP:0002605)1.75232908
162Hemorrhage of the eye (HP:0011885)1.75180157
163Polydipsia (HP:0001959)1.74375945
164Abnormal drinking behavior (HP:0030082)1.74375945
165Systemic lupus erythematosus (HP:0002725)1.73429003
166Cardiovascular calcification (HP:0011915)1.73080156
167Gingival bleeding (HP:0000225)1.72781725
168Oligodactyly (hands) (HP:0001180)1.72501371
169Volvulus (HP:0002580)1.72357182
170Absent speech (HP:0001344)1.72167159
171Hyperphosphaturia (HP:0003109)1.71829598
172Chromsome breakage (HP:0040012)1.71626107
173Hemiparesis (HP:0001269)1.71493269
174Abnormality of alkaline phosphatase activity (HP:0004379)1.71489199
175Progressive macrocephaly (HP:0004481)1.68112146
176Hypothermia (HP:0002045)1.67860381
177Hyperventilation (HP:0002883)1.67117079
178Acute encephalopathy (HP:0006846)1.67087920
179Anophthalmia (HP:0000528)1.66980234
180Abnormality of the parathyroid morphology (HP:0011766)1.65834145
181Macroorchidism (HP:0000053)1.65121761
182Acute necrotizing encephalopathy (HP:0006965)1.64350802
183Hypoplastic pelvis (HP:0008839)1.63522778
184Broad-based gait (HP:0002136)1.61809614
185Polyphagia (HP:0002591)1.61507363
186Ependymoma (HP:0002888)1.60237618

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R8.06569291
2PIK3CA4.71493696
3MAP3K23.80357498
4MAP3K42.96149044
5MAP2K22.87269055
6FRK2.79151409
7INSRR2.76109043
8IRAK32.74112134
9NME12.69839508
10EPHA32.42492954
11MET2.41618068
12MAPK132.32963175
13STK38L2.29549300
14IRAK42.23707877
15MAP4K22.21484531
16IRAK22.07287085
17STK392.02420945
18TAOK31.98209411
19VRK21.93735901
20KSR21.93065883
21BCKDK1.92570499
22PAK31.92181329
23WEE11.91233014
24IRAK11.88567401
25TAF11.86252131
26ERBB31.82499987
27CASK1.78918659
28MAP3K141.65187585
29NUAK11.59608664
30MKNK21.56819894
31FGFR21.55688185
32BMPR1B1.52164825
33PHKG11.50297923
34PHKG21.50297923
35TNK21.49705217
36PNCK1.44573482
37BRSK21.40312025
38FGFR41.36925683
39BMPR21.35833274
40MAP2K11.33717480
41EPHA21.30588933
42ERBB41.29923563
43STK31.29748439
44STK161.25543473
45MAPK151.24839883
46PBK1.17796253
47NLK1.17736729
48AKT31.17199460
49FER1.16921391
50CDK31.13870234
51LIMK11.12274747
52ACVR1B1.11863014
53ADRBK21.08429629
54MAP2K41.06567075
55PLK21.06201546
56ZAK1.00432684
57PDK20.98122961
58STK40.97170797
59TSSK60.94144670
60PLK30.91414738
61GRK10.90251200
62TXK0.86403763
63ATR0.86195479
64PIK3CG0.85687953
65IKBKE0.84972080
66PLK10.83957945
67CDK90.79503032
68TRIM280.77406757
69MAPKAPK30.76759820
70EIF2AK10.76013052
71MAP2K60.75526049
72TIE10.75185396
73MST40.74778774
74EIF2AK20.74164844
75MKNK10.72201262
76MAP3K10.71306950
77WNK30.71102465
78CSNK1A1L0.70587720
79CSNK1E0.69586543
80CSNK1G30.65563912
81MUSK0.63802610
82DYRK20.63122466
83STK110.63110243
84EIF2AK30.61096569
85MAP3K30.60926462
86BCR0.60739640
87SGK20.60354079
88CAMK2D0.59280539
89MARK10.58265784
90PLK40.57879487
91EPHA40.57866207
92PRKG20.57729561
93PIM20.55646735
94MAPK110.55151128
95CSNK1G10.53202683
96TEC0.51871504
97NEK60.51801986
98CSNK1D0.50832108
99PINK10.50526669
100JAK20.50468606
101RPS6KB20.50362758
102PRKAA20.49426862
103CCNB10.48475645
104PRKCG0.47375265
105ERBB20.45930229
106NTRK30.45683857
107NME20.43935051
108FLT30.43881210
109JAK10.43287628
110BRAF0.43200774
111CSNK1G20.42945776
112CAMK2G0.42621156
113MELK0.42415000
114ATM0.41392069
115NEK90.40277205
116PTK2B0.39914896
117CHEK10.39040150
118ADRBK10.38402873
119MAP2K70.36141028
120CAMK10.34914493
121LMTK20.34706333
122TBK10.34485117
123PRKCE0.33973550
124SGK2230.33834496
125SGK4940.33834496
126MINK10.32382171
127CHEK20.31213453
128CSNK2A20.30980315
129OXSR10.30639675
130OBSCN0.29861442
131TTK0.29237809
132PRKAA10.27889264
133TYK20.27100608
134PRKCA0.26258861
135GRK70.24866383
136STK240.24023213
137PRKCZ0.23263448
138CSNK1A10.23111332
139IKBKB0.23051709
140CHUK0.22933011
141LYN0.22642192
142PRKACG0.21476711
143WNK40.20417989
144PRKACA0.19282804
145YES10.18276195
146MAPK30.18244523
147IGF1R0.17252694
148PRKCI0.16885812
149MYLK0.15676851
150CDK80.14656039
151PRKCQ0.13656064
152VRK10.13222923
153TNIK0.12733490
154DYRK1B0.12572345
155SRPK10.11220324
156LATS10.10745396
157ITK0.10724733
158MAPK70.10331407

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.39024536
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.24753002
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18861581
4Homologous recombination_Homo sapiens_hsa034403.00840307
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.91112877
6Tryptophan metabolism_Homo sapiens_hsa003802.90779394
7Sulfur metabolism_Homo sapiens_hsa009202.58104927
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51261605
9Histidine metabolism_Homo sapiens_hsa003402.45518041
10Non-homologous end-joining_Homo sapiens_hsa034502.34469885
11Folate biosynthesis_Homo sapiens_hsa007902.31142237
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.23128169
13Arginine biosynthesis_Homo sapiens_hsa002202.20110716
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10664139
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10104750
16Phototransduction_Homo sapiens_hsa047442.09753381
17Vitamin digestion and absorption_Homo sapiens_hsa049772.08667133
18Fat digestion and absorption_Homo sapiens_hsa049752.01567255
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.94516582
20Retinol metabolism_Homo sapiens_hsa008301.94288564
21Peroxisome_Homo sapiens_hsa041461.93493991
22Butanoate metabolism_Homo sapiens_hsa006501.93353299
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92499135
24Fatty acid degradation_Homo sapiens_hsa000711.90919851
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90499415
26Fanconi anemia pathway_Homo sapiens_hsa034601.88352669
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.86025698
28Complement and coagulation cascades_Homo sapiens_hsa046101.85480796
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84563432
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.83547812
31Chemical carcinogenesis_Homo sapiens_hsa052041.80782241
32beta-Alanine metabolism_Homo sapiens_hsa004101.70005276
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68381693
34Mineral absorption_Homo sapiens_hsa049781.62230854
35Bile secretion_Homo sapiens_hsa049761.61594558
36Caffeine metabolism_Homo sapiens_hsa002321.60151223
37Starch and sucrose metabolism_Homo sapiens_hsa005001.58366018
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.58122590
39Proteasome_Homo sapiens_hsa030501.55887184
40Nitrogen metabolism_Homo sapiens_hsa009101.54796769
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49384449
42PPAR signaling pathway_Homo sapiens_hsa033201.47242055
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46514215
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42674856
45Propanoate metabolism_Homo sapiens_hsa006401.41878389
46Phenylalanine metabolism_Homo sapiens_hsa003601.39919049
47Vitamin B6 metabolism_Homo sapiens_hsa007501.38991293
48ABC transporters_Homo sapiens_hsa020101.37998323
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36194236
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33075949
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28087754
52Tyrosine metabolism_Homo sapiens_hsa003501.25722455
53Parkinsons disease_Homo sapiens_hsa050121.24659446
54Arginine and proline metabolism_Homo sapiens_hsa003301.23440158
55Staphylococcus aureus infection_Homo sapiens_hsa051501.19003645
56Steroid biosynthesis_Homo sapiens_hsa001001.14898350
57Selenocompound metabolism_Homo sapiens_hsa004501.13502282
58Mismatch repair_Homo sapiens_hsa034301.13468649
59Taste transduction_Homo sapiens_hsa047421.11420458
60Fatty acid elongation_Homo sapiens_hsa000621.08867905
61Fatty acid metabolism_Homo sapiens_hsa012121.06933459
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00873625
63Pyruvate metabolism_Homo sapiens_hsa006200.99109614
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94405843
65Glycerolipid metabolism_Homo sapiens_hsa005610.93991986
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92445965
67RNA degradation_Homo sapiens_hsa030180.87915276
68Linoleic acid metabolism_Homo sapiens_hsa005910.87193588
69Huntingtons disease_Homo sapiens_hsa050160.85246816
70Glutathione metabolism_Homo sapiens_hsa004800.84238982
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84010304
72Protein export_Homo sapiens_hsa030600.84004203
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.80147900
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77953146
75RNA transport_Homo sapiens_hsa030130.77537213
76Fatty acid biosynthesis_Homo sapiens_hsa000610.76309345
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75102930
78Galactose metabolism_Homo sapiens_hsa000520.74525016
79Base excision repair_Homo sapiens_hsa034100.72078692
80Metabolic pathways_Homo sapiens_hsa011000.72005057
81Olfactory transduction_Homo sapiens_hsa047400.70303968
82Sulfur relay system_Homo sapiens_hsa041220.69273372
83Collecting duct acid secretion_Homo sapiens_hsa049660.69104717
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.65245364
85Nucleotide excision repair_Homo sapiens_hsa034200.61893898
86Cardiac muscle contraction_Homo sapiens_hsa042600.59185512
87Circadian rhythm_Homo sapiens_hsa047100.58640654
88Arachidonic acid metabolism_Homo sapiens_hsa005900.58158989
89Nicotine addiction_Homo sapiens_hsa050330.56728657
90Renin-angiotensin system_Homo sapiens_hsa046140.52580684
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52220845
92Regulation of autophagy_Homo sapiens_hsa041400.51688235
93Fructose and mannose metabolism_Homo sapiens_hsa000510.49934282
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.48617839
95N-Glycan biosynthesis_Homo sapiens_hsa005100.48208491
96Insulin secretion_Homo sapiens_hsa049110.46483879
97Pentose phosphate pathway_Homo sapiens_hsa000300.46300189
98Carbon metabolism_Homo sapiens_hsa012000.44802923
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42401843
100Biosynthesis of amino acids_Homo sapiens_hsa012300.41354667
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41190819
102Sphingolipid metabolism_Homo sapiens_hsa006000.39078901
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35148398
104Prion diseases_Homo sapiens_hsa050200.34733358
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33951756
106Protein digestion and absorption_Homo sapiens_hsa049740.33731191
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.32106558
108Oxidative phosphorylation_Homo sapiens_hsa001900.31957544
109One carbon pool by folate_Homo sapiens_hsa006700.30976383
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30163583
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29904720
112Lysine degradation_Homo sapiens_hsa003100.28115571
113Salivary secretion_Homo sapiens_hsa049700.27625623
114Other glycan degradation_Homo sapiens_hsa005110.27002692
115Pyrimidine metabolism_Homo sapiens_hsa002400.24328203
116Ether lipid metabolism_Homo sapiens_hsa005650.21627879
117African trypanosomiasis_Homo sapiens_hsa051430.21390199
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17442925
119Pancreatic secretion_Homo sapiens_hsa049720.16553346
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.14674094
121Hepatitis C_Homo sapiens_hsa051600.13295761
122Purine metabolism_Homo sapiens_hsa002300.12774144
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.09739224
124RNA polymerase_Homo sapiens_hsa030200.09452595
125Basal transcription factors_Homo sapiens_hsa030220.08323717
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06304051
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.05513557
128Alzheimers disease_Homo sapiens_hsa050100.04125209

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