MKRN4P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)9.71588611
2cytidine metabolic process (GO:0046087)9.71588611
3cytidine catabolic process (GO:0006216)9.71588611
4pyrimidine ribonucleoside catabolic process (GO:0046133)8.88768553
5antigen processing and presentation via MHC class Ib (GO:0002475)6.80411769
6negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.66210841
7DNA deamination (GO:0045006)6.65192083
8regulation of antigen processing and presentation of peptide antigen (GO:0002583)6.51950743
9gonadal mesoderm development (GO:0007506)5.76427982
10regulation of retinoic acid receptor signaling pathway (GO:0048385)5.55897546
11pseudouridine synthesis (GO:0001522)5.10042901
12positive regulation of protein homooligomerization (GO:0032464)5.03370359
13negative regulation of organelle assembly (GO:1902116)4.98937725
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.82345488
15pyrimidine nucleoside catabolic process (GO:0046135)4.75131697
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.63998284
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.24420707
18positive regulation of synaptic transmission, GABAergic (GO:0032230)4.07838272
19positive regulation of calcium-mediated signaling (GO:0050850)4.02801137
20negative regulation by host of viral transcription (GO:0043922)4.00092325
21tRNA methylation (GO:0030488)3.93626509
22urinary tract smooth muscle contraction (GO:0014848)3.92075734
23nerve growth factor signaling pathway (GO:0038180)3.85646872
24negative regulation of interleukin-1 beta production (GO:0032691)3.83059819
25eosinophil chemotaxis (GO:0048245)3.82801818
26positive regulation of antigen processing and presentation (GO:0002579)3.79554067
27negative regulation of amino acid transport (GO:0051956)3.78301528
28DNA demethylation (GO:0080111)3.69276524
29negative regulation of calcium ion transport into cytosol (GO:0010523)3.63732826
30ncRNA 3-end processing (GO:0043628)3.52214066
31protein neddylation (GO:0045116)3.49521174
32pyrimidine-containing compound catabolic process (GO:0072529)3.45926303
33antigen processing and presentation of endogenous antigen (GO:0019883)3.45297639
34kidney morphogenesis (GO:0060993)3.43845966
35negative regulation of interleukin-1 production (GO:0032692)3.42386648
36eosinophil migration (GO:0072677)3.40025326
37regulation of glutamate secretion (GO:0014048)3.39750176
38postsynaptic membrane organization (GO:0001941)3.39726616
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37930374
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.37930374
41NADH dehydrogenase complex assembly (GO:0010257)3.37930374
42metallo-sulfur cluster assembly (GO:0031163)3.36428189
43iron-sulfur cluster assembly (GO:0016226)3.36428189
44positive regulation of interleukin-1 beta secretion (GO:0050718)3.33627611
45mannosylation (GO:0097502)3.27132245
46regulation of meiosis I (GO:0060631)3.22652424
47atrial cardiac muscle cell action potential (GO:0086014)3.19363949
48protein polyglutamylation (GO:0018095)3.14876113
49positive regulation of release of cytochrome c from mitochondria (GO:0090200)3.14151550
50positive regulation of ERBB signaling pathway (GO:1901186)3.13670157
51positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.11358299
52T cell migration (GO:0072678)3.10338550
53granulocyte activation (GO:0036230)3.07697417
54positive regulation of interleukin-1 secretion (GO:0050716)3.07380944
55response to nerve growth factor (GO:1990089)3.06749186
56cellular response to nerve growth factor stimulus (GO:1990090)3.06749186
57negative regulation of telomere maintenance (GO:0032205)3.05884628
58chaperone mediated protein folding requiring cofactor (GO:0051085)3.04611758
59cellular response to interleukin-15 (GO:0071350)3.02951270
60protein complex biogenesis (GO:0070271)3.02103279
61regulation of cilium assembly (GO:1902017)3.01434159
62macrophage chemotaxis (GO:0048246)3.01216456
63regulation of microtubule-based movement (GO:0060632)3.01138075
64negative T cell selection (GO:0043383)2.97030477
65transcription from mitochondrial promoter (GO:0006390)2.96771750
66regulation of interleukin-1 beta secretion (GO:0050706)2.95028385
67regulation of defense response to virus by virus (GO:0050690)2.89853528
68DNA dealkylation (GO:0035510)2.87656764
69regulation of protein heterodimerization activity (GO:0043497)2.86328187
70positive regulation of natural killer cell differentiation (GO:0032825)2.84559323
71positive regulation of mitochondrial fission (GO:0090141)2.83250263
72peristalsis (GO:0030432)2.83110972
73sarcoplasmic reticulum calcium ion transport (GO:0070296)2.81025529
74activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.80183884
75sulfate transport (GO:0008272)2.79954555
76behavioral response to nicotine (GO:0035095)2.79087773
77carbohydrate phosphorylation (GO:0046835)2.78607443
78negative regulation of viral transcription (GO:0032897)2.76634065
79positive regulation of neutrophil chemotaxis (GO:0090023)2.75516135
80positive regulation of neutrophil migration (GO:1902624)2.75516135
81positive regulation of respiratory burst (GO:0060267)2.74218218
82regulation of calcium-mediated signaling (GO:0050848)2.72903932
83regulation of antigen processing and presentation (GO:0002577)2.70234569
84regulation of protein homooligomerization (GO:0032462)2.70020117
85mitochondrial respiratory chain complex assembly (GO:0033108)2.68517261
86positive regulation of defense response to virus by host (GO:0002230)2.67620375
87arginine catabolic process (GO:0006527)2.65339817
88response to xenobiotic stimulus (GO:0009410)2.62524869
89protein refolding (GO:0042026)2.60202413
90proteasome assembly (GO:0043248)2.59588628
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57987808
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57987808
93negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57720083
94negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.56407582
95positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.56228078
96cellular response to nicotine (GO:0071316)2.54428473
97positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.52981918
98positive T cell selection (GO:0043368)2.52384125
99tRNA processing (GO:0008033)2.50464023
100positive regulation of guanylate cyclase activity (GO:0031284)2.50246447

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.31433618
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.23991760
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.41689250
4GATA1_22025678_ChIP-Seq_K562_Human3.71668815
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.15667020
6ZNF274_21170338_ChIP-Seq_K562_Hela3.04703246
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.96732850
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63753291
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61271441
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.42599466
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24322020
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.21638158
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20570296
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.20282454
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18225803
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.10565156
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08602006
18SRY_22984422_ChIP-ChIP_TESTIS_Rat1.98231754
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89444431
20EZH2_22144423_ChIP-Seq_EOC_Human1.89363293
21BCL6_27268052_Chip-Seq_Bcells_Human1.83959370
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73451440
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.73404578
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.73404578
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.73404578
26TP53_22573176_ChIP-Seq_HFKS_Human1.71862463
27YY1_22570637_ChIP-Seq_MALME-3M_Human1.63525120
28CTCF_20526341_ChIP-Seq_ESCs_Human1.63094476
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.61477839
30GATA3_21878914_ChIP-Seq_MCF-7_Human1.61312333
31ERA_21632823_ChIP-Seq_H3396_Human1.57283372
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56616180
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56592673
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.56577366
35MYB_26560356_Chip-Seq_TH2_Human1.56307376
36MYC_19829295_ChIP-Seq_ESCs_Human1.56086544
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54790425
38GATA3_26560356_Chip-Seq_TH2_Human1.54284216
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53412145
40GABP_19822575_ChIP-Seq_HepG2_Human1.53054931
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50445042
42IRF1_19129219_ChIP-ChIP_H3396_Human1.49085308
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49075977
44VDR_23849224_ChIP-Seq_CD4+_Human1.47241990
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46475500
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45392551
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44781070
48FOXP3_21729870_ChIP-Seq_TREG_Human1.43486286
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41050540
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40784047
51NANOG_20526341_ChIP-Seq_ESCs_Human1.35818331
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34536504
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29283385
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29167504
55BCOR_27268052_Chip-Seq_Bcells_Human1.25240973
56RAC3_21632823_ChIP-Seq_H3396_Human1.23290473
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20040989
58TAF2_19829295_ChIP-Seq_ESCs_Human1.19031018
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17251344
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16903519
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.15609099
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15447056
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.14227776
64PHF8_20622854_ChIP-Seq_HELA_Human1.13915928
65DCP1A_22483619_ChIP-Seq_HELA_Human1.11575967
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11346178
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11339611
68HOXB7_26014856_ChIP-Seq_BT474_Human1.10676398
69P53_21459846_ChIP-Seq_SAOS-2_Human1.10153885
70MYC_22102868_ChIP-Seq_BL_Human1.09613071
71GATA3_27048872_Chip-Seq_THYMUS_Human1.09528455
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06352127
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06323848
74E2F1_20622854_ChIP-Seq_HELA_Human1.05704060
75P68_20966046_ChIP-Seq_HELA_Human1.05624883
76IGF1R_20145208_ChIP-Seq_DFB_Human1.04999216
77SA1_27219007_Chip-Seq_Bcells_Human1.04382759
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03944726
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03921324
80MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01959793
81OCT4_19829295_ChIP-Seq_ESCs_Human1.00310080
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00085694
83FOXH1_21741376_ChIP-Seq_EPCs_Human1.00001283
84RNF2_27304074_Chip-Seq_NSC_Mouse0.99358457
85REST_21632747_ChIP-Seq_MESCs_Mouse0.99326826
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99016898
87RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97918555
88OCT4_20526341_ChIP-Seq_ESCs_Human0.97827319
89CTCF_26484167_Chip-Seq_Bcells_Mouse0.97291816
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96461613
91LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96213805
92REST_18959480_ChIP-ChIP_MESCs_Mouse0.95202033
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95158130
94MYC_18940864_ChIP-ChIP_HL60_Human0.94880481
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94488081
96UTX_26944678_Chip-Seq_JUKART_Human0.94445710
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.94180242
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94022145
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91835949
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90837756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.05039685
2MP0004147_increased_porphyrin_level4.32185816
3MP0001348_abnormal_lacrimal_gland3.77041817
4MP0002735_abnormal_chemical_nociception3.46524237
5MP0005671_abnormal_response_to3.38521242
6MP0005167_abnormal_blood-brain_barrier3.34351949
7MP0009333_abnormal_splenocyte_physiolog3.07170516
8MP0006082_CNS_inflammation2.50135868
9MP0009785_altered_susceptibility_to2.39169974
10MP0002148_abnormal_hypersensitivity_rea2.02369555
11MP0002102_abnormal_ear_morphology2.02019466
12MP0001986_abnormal_taste_sensitivity1.93830756
13MP0008872_abnormal_physiological_respon1.89946262
14MP0002736_abnormal_nociception_after1.86498310
15MP0005423_abnormal_somatic_nervous1.84052325
16MP0000372_irregular_coat_pigmentation1.83147526
17MP0001849_ear_inflammation1.76893309
18MP0003137_abnormal_impulse_conducting1.68045734
19MP0005645_abnormal_hypothalamus_physiol1.66644561
20MP0005000_abnormal_immune_tolerance1.66174011
21MP0002822_catalepsy1.63022453
22MP0001970_abnormal_pain_threshold1.57309080
23MP0001529_abnormal_vocalization1.56481684
24MP0002733_abnormal_thermal_nociception1.52404240
25MP0009840_abnormal_foam_cell1.52318397
26MP0003787_abnormal_imprinting1.52022373
27MP0006276_abnormal_autonomic_nervous1.51905123
28MP0002837_dystrophic_cardiac_calcinosis1.49151718
29MP0003718_maternal_effect1.44626389
30MP0000604_amyloidosis1.42088275
31MP0001800_abnormal_humoral_immune1.41892220
32MP0009764_decreased_sensitivity_to1.40908924
33MP0002254_reproductive_system_inflammat1.39878760
34MP0002723_abnormal_immune_serum1.39612528
35MP0001835_abnormal_antigen_presentation1.37189881
36MP0005257_abnormal_intraocular_pressure1.34526435
37MP0002420_abnormal_adaptive_immunity1.33687144
38MP0004043_abnormal_pH_regulation1.32920871
39MP0001819_abnormal_immune_cell1.31903250
40MP0003724_increased_susceptibility_to1.31542345
41MP0005670_abnormal_white_adipose1.31261491
42MP0010307_abnormal_tumor_latency1.28617909
43MP0005410_abnormal_fertilization1.28340467
44MP0002734_abnormal_mechanical_nocicepti1.27710865
45MP0003436_decreased_susceptibility_to1.27655841
46MP0002876_abnormal_thyroid_physiology1.25953677
47MP0002452_abnormal_antigen_presenting1.20701059
48MP0009765_abnormal_xenobiotic_induced1.20404208
49MP0009046_muscle_twitch1.17304640
50MP0005387_immune_system_phenotype1.16992154
51MP0001790_abnormal_immune_system1.16992154
52MP0005025_abnormal_response_to1.16623319
53MP0001968_abnormal_touch/_nociception1.16162699
54MP0002638_abnormal_pupillary_reflex1.13317466
55MP0001188_hyperpigmentation1.11594982
56MP0009745_abnormal_behavioral_response1.10816333
57MP0004270_analgesia1.08187863
58MP0003183_abnormal_peptide_metabolism1.06479485
59MP0003763_abnormal_thymus_physiology1.05179970
60MP0003329_amyloid_beta_deposits1.05056694
61MP0003075_altered_response_to1.03657984
62MP0000716_abnormal_immune_system1.03480460
63MP0000685_abnormal_immune_system1.00106438
64MP0005058_abnormal_lysosome_morphology0.99427776
65MP0004859_abnormal_synaptic_plasticity0.95170955
66MP0004924_abnormal_behavior0.95161642
67MP0005386_behavior/neurological_phenoty0.95161642
68MP0002653_abnormal_ependyma_morphology0.94787424
69MP0004185_abnormal_adipocyte_glucose0.94024607
70MP0006036_abnormal_mitochondrial_physio0.93028736
71MP0002332_abnormal_exercise_endurance0.90949227
72MP0002163_abnormal_gland_morphology0.90310086
73MP0002063_abnormal_learning/memory/cond0.86510348
74MP0010386_abnormal_urinary_bladder0.86365291
75MP0008874_decreased_physiological_sensi0.85394496
76MP0002067_abnormal_sensory_capabilities0.83791267
77MP0000681_abnormal_thyroid_gland0.82728757
78MP0001905_abnormal_dopamine_level0.81999897
79MP0002398_abnormal_bone_marrow0.81772168
80MP0002429_abnormal_blood_cell0.79426440
81MP0001919_abnormal_reproductive_system0.78991256
82MP0003806_abnormal_nucleotide_metabolis0.78058694
83MP0005647_abnormal_sex_gland0.76800691
84MP0002127_abnormal_cardiovascular_syste0.76558674
85MP0002751_abnormal_autonomic_nervous0.75303867
86MP0005377_hearing/vestibular/ear_phenot0.74750840
87MP0003878_abnormal_ear_physiology0.74750840
88MP0002419_abnormal_innate_immunity0.74378243
89MP0005389_reproductive_system_phenotype0.72602920
90MP0010155_abnormal_intestine_physiology0.71653304
91MP0002277_abnormal_respiratory_mucosa0.71468200
92MP0003303_peritoneal_inflammation0.70637667
93MP0000230_abnormal_systemic_arterial0.68411063
94MP0003186_abnormal_redox_activity0.68346456
95MP0002572_abnormal_emotion/affect_behav0.68326240
96MP0001845_abnormal_inflammatory_respons0.66498501
97MP0008260_abnormal_autophagy0.64959423
98MP0000689_abnormal_spleen_morphology0.64835293
99MP0005464_abnormal_platelet_physiology0.64644052
100MP0003635_abnormal_synaptic_transmissio0.64373650

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)9.12736957
2Breast hypoplasia (HP:0003187)6.59169180
3Microretrognathia (HP:0000308)6.01008263
4Type II lissencephaly (HP:0007260)4.60973379
5T lymphocytopenia (HP:0005403)3.82046843
6Aplasia/Hypoplasia of the sternum (HP:0006714)3.73077096
7Abnormality of T cell number (HP:0011839)3.53451842
8Cerebellar dysplasia (HP:0007033)3.53215118
9Carpal bone hypoplasia (HP:0001498)3.51372994
10Patellar aplasia (HP:0006443)3.38353558
11Diastasis recti (HP:0001540)3.25825861
12Anterior segment dysgenesis (HP:0007700)3.21460696
13Myokymia (HP:0002411)3.16817555
14Aplasia/Hypoplasia involving the musculature (HP:0001460)3.15164489
15Stomatitis (HP:0010280)3.06847601
16Aplasia/Hypoplasia of the patella (HP:0006498)3.06509812
17Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.02824093
18Lissencephaly (HP:0001339)3.00098068
19Mutism (HP:0002300)2.91194617
20Inability to walk (HP:0002540)2.81173033
21Abnormality of lateral ventricle (HP:0030047)2.78886499
223-Methylglutaconic aciduria (HP:0003535)2.78809822
23Increased intramyocellular lipid droplets (HP:0012240)2.76624035
24Slender long bone (HP:0003100)2.74486553
25Dysautonomia (HP:0002459)2.68698901
26IgG deficiency (HP:0004315)2.64596814
27Chronic diarrhea (HP:0002028)2.63097034
28Type I transferrin isoform profile (HP:0003642)2.62853249
29Nasal speech (HP:0001611)2.62845307
30Hypoplasia of the brainstem (HP:0002365)2.62706360
31Aplasia/Hypoplasia of the brainstem (HP:0007362)2.62706360
32Severe combined immunodeficiency (HP:0004430)2.58634593
33Aplasia/hypoplasia of the uterus (HP:0008684)2.53830691
34Renal Fanconi syndrome (HP:0001994)2.49829984
35Pancreatic cysts (HP:0001737)2.46282353
36Abnormality of the clitoris (HP:0000056)2.44541267
37Vacuolated lymphocytes (HP:0001922)2.40607352
38Reduced antithrombin III activity (HP:0001976)2.39401329
39Methylmalonic aciduria (HP:0012120)2.38851488
40Large eyes (HP:0001090)2.35557916
41Arthropathy (HP:0003040)2.33143569
42Diaphragmatic weakness (HP:0009113)2.31715842
43Long foot (HP:0001833)2.30815161
44Hyperventilation (HP:0002883)2.28151941
45Abnormality of T cells (HP:0002843)2.26094996
46IgA deficiency (HP:0002720)2.25781917
47Chronic mucocutaneous candidiasis (HP:0002728)2.24162435
48Recurrent cutaneous fungal infections (HP:0011370)2.24162435
49Encephalitis (HP:0002383)2.22968359
50Poor head control (HP:0002421)2.22593250
51Retinal dysplasia (HP:0007973)2.22469063
52Aplastic anemia (HP:0001915)2.21342708
53Paralysis (HP:0003470)2.17962969
54Poor speech (HP:0002465)2.15159622
55Abnormality of alanine metabolism (HP:0010916)2.14258028
56Hyperalaninemia (HP:0003348)2.14258028
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14258028
58Genu varum (HP:0002970)2.12108391
59Progressive microcephaly (HP:0000253)2.11747603
60Abnormality of glycolipid metabolism (HP:0010969)2.07661100
61Abnormality of liposaccharide metabolism (HP:0010968)2.07661100
62Abnormality of glycosphingolipid metabolism (HP:0004343)2.07661100
63Increased muscle lipid content (HP:0009058)2.06156441
64Combined immunodeficiency (HP:0005387)2.06153764
65Mitochondrial inheritance (HP:0001427)2.05967032
66Abnormality of the pons (HP:0007361)2.05766804
67Short tibia (HP:0005736)2.01818868
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00895657
69Congenital stationary night blindness (HP:0007642)1.99938803
70Female pseudohermaphroditism (HP:0010458)1.99731680
71Hypoplasia of the pons (HP:0012110)1.99084837
72Fibular aplasia (HP:0002990)1.97644422
73Hypercortisolism (HP:0001578)1.96559995
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.94412042
75Recurrent corneal erosions (HP:0000495)1.94259376
76Abnormal mitochondria in muscle tissue (HP:0008316)1.93996702
77Episodic fever (HP:0001954)1.91396279
78Acute necrotizing encephalopathy (HP:0006965)1.91058395
79Microtia (HP:0008551)1.88855922
80Methylmalonic acidemia (HP:0002912)1.88138380
81Scrotal hypoplasia (HP:0000046)1.87194980
82Global brain atrophy (HP:0002283)1.86996360
83Abnormal protein N-linked glycosylation (HP:0012347)1.86638919
84Abnormal protein glycosylation (HP:0012346)1.86638919
85Abnormal glycosylation (HP:0012345)1.86638919
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86638919
87Hypoproteinemia (HP:0003075)1.86322854
88Autoimmune thrombocytopenia (HP:0001973)1.86226625
89Muscular dystrophy (HP:0003560)1.86037840
90Breast aplasia (HP:0100783)1.85677626
91Increased CSF lactate (HP:0002490)1.84857123
92Partial agenesis of the corpus callosum (HP:0001338)1.84635410
93Depressed nasal tip (HP:0000437)1.84499318
94Torticollis (HP:0000473)1.83095962
95Severe muscular hypotonia (HP:0006829)1.82957762
96Abolished electroretinogram (ERG) (HP:0000550)1.82438894
97Recurrent viral infections (HP:0004429)1.82147374
98Progressive inability to walk (HP:0002505)1.81610619
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79955853
100Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79711829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.05088436
2DAPK24.54067720
3BMPR1B3.47857919
4KDR3.38141244
5TXK3.24625483
6CASK3.16552692
7TESK23.02024674
8MATK2.84097139
9NTRK12.77367130
10MAP4K22.76902091
11BCKDK2.63104469
12CAMKK12.40860620
13LMTK22.35525934
14BMX2.31886287
15ADRBK22.22523587
16NME12.21400356
17TAOK32.18915513
18BUB11.77178442
19MAP2K61.71417256
20WNK41.58699678
21TNIK1.56455802
22SIK21.55174882
23PINK11.33079716
24TGFBR11.24488559
25MAPKAPK51.21115267
26SCYL21.14741902
27STK161.14263092
28MAPK131.07203222
29PIM21.02738355
30BCR1.02570571
31CSF1R1.01448370
32EPHA30.96233876
33PAK60.93900877
34TESK10.93273948
35MAP2K70.90707863
36ZAK0.90687001
37IKBKB0.89019872
38PHKG20.88704255
39PHKG10.88704255
40MAP4K10.88127367
41NTRK20.87911320
42MARK10.86415139
43PRKCQ0.84996351
44NEK20.82880296
45ITK0.82476362
46ADRBK10.80412909
47SRPK10.80052154
48LYN0.78857965
49CAMKK20.78091757
50TAOK20.77376976
51SYK0.73184757
52PIM10.71575826
53FGR0.70668380
54STK38L0.69046128
55BMPR20.67674582
56GRK10.65399402
57CAMK2A0.65135755
58EIF2AK30.58569917
59AURKA0.57686413
60CAMK40.55924686
61LCK0.55771366
62CDC42BPA0.51584673
63CHUK0.50417630
64NEK90.49977871
65PLK40.47786666
66PKN10.47759524
67MARK30.47346037
68GRK70.45572152
69PDK20.44792156
70ERBB20.43143494
71BLK0.42010490
72MAPK110.41429495
73FES0.41288549
74MAP3K140.38247326
75CSNK1A10.36953380
76GRK60.36872387
77TYRO30.36508066
78INSRR0.35935301
79PTK2B0.33745378
80INSR0.33688138
81TRIM280.32760627
82BRSK10.29525729
83IGF1R0.28852702
84PLK10.28835817
85CSK0.28364302
86LIMK10.26934604
87CDK190.26798095
88PRKCZ0.22859120
89PRPF4B0.22790384
90PLK20.21633736
91PRKG20.21419346
92PRKCD0.21037799
93CAMK1D0.20442438
94CDK11A0.20222827
95ILK0.19565265
96ZAP700.18954075
97ERBB30.18816171
98PRKCI0.18693270
99RPS6KA60.18015612
100CDK140.17619742

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.20862012
2Antigen processing and presentation_Homo sapiens_hsa046123.19120162
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.08780627
4Folate biosynthesis_Homo sapiens_hsa007902.79705157
5Sulfur metabolism_Homo sapiens_hsa009202.64477703
6Proteasome_Homo sapiens_hsa030502.36878995
7Autoimmune thyroid disease_Homo sapiens_hsa053202.27952824
8Graft-versus-host disease_Homo sapiens_hsa053322.16663085
9Rheumatoid arthritis_Homo sapiens_hsa053232.13019677
10Allograft rejection_Homo sapiens_hsa053302.10941676
11Collecting duct acid secretion_Homo sapiens_hsa049662.06748490
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.04874876
13T cell receptor signaling pathway_Homo sapiens_hsa046601.99765235
14Hematopoietic cell lineage_Homo sapiens_hsa046401.99185440
15Regulation of autophagy_Homo sapiens_hsa041401.94141697
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.81915725
17Oxidative phosphorylation_Homo sapiens_hsa001901.76302102
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76160256
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72337445
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72250560
21Fatty acid biosynthesis_Homo sapiens_hsa000611.66852182
22Lysosome_Homo sapiens_hsa041421.65036244
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61753633
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.45050785
25Parkinsons disease_Homo sapiens_hsa050121.42870310
26Nicotine addiction_Homo sapiens_hsa050331.37176501
27Protein export_Homo sapiens_hsa030601.33478627
28Salmonella infection_Homo sapiens_hsa051321.33433671
29Phototransduction_Homo sapiens_hsa047441.29113246
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29108752
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19824715
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.15132828
33Type I diabetes mellitus_Homo sapiens_hsa049401.13884871
34Nitrogen metabolism_Homo sapiens_hsa009101.11496506
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.08891613
36Pyrimidine metabolism_Homo sapiens_hsa002401.04928539
37Selenocompound metabolism_Homo sapiens_hsa004501.04771972
38mRNA surveillance pathway_Homo sapiens_hsa030151.03613401
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98533256
40Measles_Homo sapiens_hsa051620.97295825
41RNA polymerase_Homo sapiens_hsa030200.92613249
42Shigellosis_Homo sapiens_hsa051310.91973447
43Huntingtons disease_Homo sapiens_hsa050160.91806159
44Synaptic vesicle cycle_Homo sapiens_hsa047210.91149694
45Spliceosome_Homo sapiens_hsa030400.90876256
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90683391
47Viral myocarditis_Homo sapiens_hsa054160.88875948
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87793923
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83946992
50Bladder cancer_Homo sapiens_hsa052190.82816763
51Phagosome_Homo sapiens_hsa041450.81076843
52ABC transporters_Homo sapiens_hsa020100.79330359
53Endocytosis_Homo sapiens_hsa041440.78614775
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77930749
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77417349
56DNA replication_Homo sapiens_hsa030300.75819893
57Basal transcription factors_Homo sapiens_hsa030220.73601796
58African trypanosomiasis_Homo sapiens_hsa051430.72744386
59Asthma_Homo sapiens_hsa053100.72653495
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70561399
61Legionellosis_Homo sapiens_hsa051340.70336717
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66856582
63RNA degradation_Homo sapiens_hsa030180.63714147
64GABAergic synapse_Homo sapiens_hsa047270.62448915
65Herpes simplex infection_Homo sapiens_hsa051680.62216772
66p53 signaling pathway_Homo sapiens_hsa041150.62157436
67Alzheimers disease_Homo sapiens_hsa050100.62083547
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61554846
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60070095
70Arginine and proline metabolism_Homo sapiens_hsa003300.60037871
71Apoptosis_Homo sapiens_hsa042100.59983170
72Tyrosine metabolism_Homo sapiens_hsa003500.58907015
73RNA transport_Homo sapiens_hsa030130.57951760
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57358456
75Base excision repair_Homo sapiens_hsa034100.56588946
76Cell cycle_Homo sapiens_hsa041100.55148633
77Cardiac muscle contraction_Homo sapiens_hsa042600.54133278
78Morphine addiction_Homo sapiens_hsa050320.53424775
79One carbon pool by folate_Homo sapiens_hsa006700.52247827
80Ovarian steroidogenesis_Homo sapiens_hsa049130.52027060
81Epstein-Barr virus infection_Homo sapiens_hsa051690.51959906
82Vibrio cholerae infection_Homo sapiens_hsa051100.51796384
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49253540
84Malaria_Homo sapiens_hsa051440.45981090
85TNF signaling pathway_Homo sapiens_hsa046680.45197454
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45160252
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42934011
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40771525
89Olfactory transduction_Homo sapiens_hsa047400.38867161
90Purine metabolism_Homo sapiens_hsa002300.37072119
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36376288
92Homologous recombination_Homo sapiens_hsa034400.35935658
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35170292
94Linoleic acid metabolism_Homo sapiens_hsa005910.34848025
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33765010
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32328486
97Influenza A_Homo sapiens_hsa051640.31647272
98Staphylococcus aureus infection_Homo sapiens_hsa051500.30558753
99Metabolic pathways_Homo sapiens_hsa011000.28208076
100Chemokine signaling pathway_Homo sapiens_hsa040620.28173121

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