MKRN5P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1limb bud formation (GO:0060174)5.78602805
2regulation of protein kinase A signaling (GO:0010738)5.46423474
3detection of light stimulus involved in sensory perception (GO:0050962)4.87643192
4detection of light stimulus involved in visual perception (GO:0050908)4.87643192
5establishment of protein localization to Golgi (GO:0072600)4.59337556
6neuronal action potential propagation (GO:0019227)4.41195041
7cyclic nucleotide catabolic process (GO:0009214)4.33634144
8cAMP catabolic process (GO:0006198)4.22120504
9protein targeting to Golgi (GO:0000042)4.10384669
10negative regulation of mast cell activation (GO:0033004)4.10095449
11regulation of action potential (GO:0098900)4.09563976
12protein polyglutamylation (GO:0018095)4.09128843
13mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.96127649
14positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.96127649
15establishment of mitochondrion localization (GO:0051654)3.92390468
16negative regulation of cytosolic calcium ion concentration (GO:0051481)3.87778288
17pyrimidine nucleobase catabolic process (GO:0006208)3.86810092
18regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.81087979
19membrane depolarization during action potential (GO:0086010)3.79810144
20retrograde transport, vesicle recycling within Golgi (GO:0000301)3.78908296
21protein localization to synapse (GO:0035418)3.76219237
22response to inactivity (GO:0014854)3.74906765
23regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.62014062
24mitochondrion transport along microtubule (GO:0047497)3.50392333
25establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.50392333
26neural tube formation (GO:0001841)3.49635026
27auditory behavior (GO:0031223)3.42955322
28cellular ketone body metabolic process (GO:0046950)3.42800377
29sarcoplasmic reticulum calcium ion transport (GO:0070296)3.37895774
30regulation of hippo signaling (GO:0035330)3.34568046
31estrogen biosynthetic process (GO:0006703)3.31771825
32regulation of relaxation of muscle (GO:1901077)3.31272592
33calcium ion import (GO:0070509)3.30509648
34positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.29051111
35cell migration in hindbrain (GO:0021535)3.25696004
36protein localization to Golgi apparatus (GO:0034067)3.20498597
37presynaptic membrane assembly (GO:0097105)3.19817652
38establishment of nucleus localization (GO:0040023)3.18964467
39somite development (GO:0061053)3.14958928
40nucleobase catabolic process (GO:0046113)3.12926657
41response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.05138622
42sympathetic nervous system development (GO:0048485)3.04251246
43regulation of cell communication by electrical coupling (GO:0010649)3.04084661
44regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.03603974
45myelin assembly (GO:0032288)2.98692375
46ketone body metabolic process (GO:1902224)2.97905757
47dendrite morphogenesis (GO:0048813)2.93812601
48regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93108898
49positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.88177208
50intraciliary transport (GO:0042073)2.85846175
51positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.84060595
52proline transport (GO:0015824)2.83269601
53intra-Golgi vesicle-mediated transport (GO:0006891)2.81287137
54postsynaptic membrane organization (GO:0001941)2.81087634
55presynaptic membrane organization (GO:0097090)2.80205359
56glial cell proliferation (GO:0014009)2.79708245
57nucleus localization (GO:0051647)2.75948923
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.75534144
59regulation of hexokinase activity (GO:1903299)2.75467228
60regulation of glucokinase activity (GO:0033131)2.75467228
61magnesium ion transport (GO:0015693)2.73871459
62mechanosensory behavior (GO:0007638)2.72017053
63C4-dicarboxylate transport (GO:0015740)2.69950166
64response to pheromone (GO:0019236)2.67054451
65cytoplasmic mRNA processing body assembly (GO:0033962)2.66545812
66L-fucose catabolic process (GO:0042355)2.63634971
67fucose catabolic process (GO:0019317)2.63634971
68L-fucose metabolic process (GO:0042354)2.63634971
69negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63604383
70negative regulation of translation, ncRNA-mediated (GO:0040033)2.63604383
71regulation of translation, ncRNA-mediated (GO:0045974)2.63604383
72G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62466829
73regulation of skeletal muscle contraction (GO:0014819)2.59661765
74cGMP metabolic process (GO:0046068)2.58924321
75axonal fasciculation (GO:0007413)2.58772658
76righting reflex (GO:0060013)2.58383526
77pyrimidine dimer repair (GO:0006290)2.56355806
78myofibril assembly (GO:0030239)2.54511833
79negative regulation of nitric-oxide synthase activity (GO:0051001)2.54007856
80response to auditory stimulus (GO:0010996)2.52589932
81nerve growth factor signaling pathway (GO:0038180)2.52238183
82startle response (GO:0001964)2.51943165
83response to redox state (GO:0051775)2.49914018
84calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.48408222
85water-soluble vitamin biosynthetic process (GO:0042364)2.48116422
86regulation of axon guidance (GO:1902667)2.47722540
87centrosome localization (GO:0051642)2.44637892
88sialylation (GO:0097503)2.44096222
89cardiac ventricle formation (GO:0003211)2.44043169
90cornea development in camera-type eye (GO:0061303)2.43802695
91retinal ganglion cell axon guidance (GO:0031290)2.41677354
92adult heart development (GO:0007512)2.39427817
93vitamin transmembrane transport (GO:0035461)2.39004586
94macroautophagy (GO:0016236)2.38960924
95smooth muscle tissue development (GO:0048745)2.38242275
96exploration behavior (GO:0035640)2.33896359
97cellular response to sterol (GO:0036315)2.32962028
98urinary tract smooth muscle contraction (GO:0014848)2.30683991
99somite rostral/caudal axis specification (GO:0032525)2.30378707
100cardiac chamber formation (GO:0003207)2.30243249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.92449516
2EZH2_22144423_ChIP-Seq_EOC_Human3.64612514
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94284059
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.85262674
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80247633
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60455226
7IGF1R_20145208_ChIP-Seq_DFB_Human2.57813749
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45487640
9ZNF274_21170338_ChIP-Seq_K562_Hela2.41762986
10SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.39084156
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36840416
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33974734
13FUS_26573619_Chip-Seq_HEK293_Human2.16681264
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.14844159
15SMAD4_21799915_ChIP-Seq_A2780_Human2.09546741
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.04545884
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04497916
18TAF15_26573619_Chip-Seq_HEK293_Human1.96835853
19P300_19829295_ChIP-Seq_ESCs_Human1.96602515
20ER_23166858_ChIP-Seq_MCF-7_Human1.94937537
21AR_21572438_ChIP-Seq_LNCaP_Human1.87420659
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84379227
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82636899
24STAT3_23295773_ChIP-Seq_U87_Human1.81750123
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80612693
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.79817626
27VDR_22108803_ChIP-Seq_LS180_Human1.74751404
28NR3C1_21868756_ChIP-Seq_MCF10A_Human1.72411223
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.72152347
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.68893091
31TCF4_23295773_ChIP-Seq_U87_Human1.68866935
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65366599
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64084613
34TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.63898138
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62289485
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59781871
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58221011
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53360830
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53090161
40CBP_20019798_ChIP-Seq_JUKART_Human1.52067422
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52067422
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50682225
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50206475
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.48015636
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.44354860
46BCAT_22108803_ChIP-Seq_LS180_Human1.44137286
47AR_25329375_ChIP-Seq_VCAP_Human1.43730738
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43500838
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43500838
50EWS_26573619_Chip-Seq_HEK293_Human1.41157883
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.40332245
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.38217511
53RUNX2_22187159_ChIP-Seq_PCA_Human1.37124603
54AHR_22903824_ChIP-Seq_MCF-7_Human1.35531567
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33402573
56TCF4_22108803_ChIP-Seq_LS180_Human1.30015915
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.29954940
58REST_21632747_ChIP-Seq_MESCs_Mouse1.29131103
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28416451
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.28002511
61RNF2_27304074_Chip-Seq_NSC_Mouse1.26205124
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.25326937
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23536576
64TP53_16413492_ChIP-PET_HCT116_Human1.23202091
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.22321075
66P53_22387025_ChIP-Seq_ESCs_Mouse1.22293162
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21436783
68KDM2B_26808549_Chip-Seq_REH_Human1.21378216
69SOX2_19829295_ChIP-Seq_ESCs_Human1.18886131
70NANOG_19829295_ChIP-Seq_ESCs_Human1.18886131
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18094218
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16102342
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15539270
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.14463974
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.12912302
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12783316
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12651571
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12651571
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12401043
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.12050674
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11686516
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.09928554
83RXR_22108803_ChIP-Seq_LS180_Human1.09805496
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.08613710
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.08027739
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06800673
87TBL1_22424771_ChIP-Seq_293T_Human1.06654216
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06476186
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02923135
90TP53_18474530_ChIP-ChIP_U2OS_Human1.01067772
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00868367
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.00395420
93RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99227679
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99087869
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98506642
96SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98321985
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97274673
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.97104309
99IRF1_19129219_ChIP-ChIP_H3396_Human0.97041300
100DROSHA_22980978_ChIP-Seq_HELA_Human0.96920946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy7.86907216
2MP0000569_abnormal_digit_pigmentation4.64638518
3MP0004145_abnormal_muscle_electrophysio3.47846235
4MP0004270_analgesia3.47180709
5MP0001529_abnormal_vocalization2.99012836
6MP0006276_abnormal_autonomic_nervous2.53333007
7MP0005423_abnormal_somatic_nervous2.43273027
8MP0003880_abnormal_central_pattern2.18647183
9MP0003787_abnormal_imprinting2.13509663
10MP0000749_muscle_degeneration2.04636760
11MP0002735_abnormal_chemical_nociception2.03431801
12MP0002638_abnormal_pupillary_reflex1.85381582
13MP0004924_abnormal_behavior1.78223353
14MP0005386_behavior/neurological_phenoty1.78223353
15MP0004859_abnormal_synaptic_plasticity1.77388082
16MP0009046_muscle_twitch1.71992867
17MP0004484_altered_response_of1.65715202
18MP0005670_abnormal_white_adipose1.63672997
19MP0003950_abnormal_plasma_membrane1.59154461
20MP0008877_abnormal_DNA_methylation1.55015462
21MP0004142_abnormal_muscle_tone1.54350713
22MP0000747_muscle_weakness1.52112585
23MP0002909_abnormal_adrenal_gland1.47986388
24MP0002734_abnormal_mechanical_nocicepti1.47743671
25MP0000751_myopathy1.45970221
26MP0005551_abnormal_eye_electrophysiolog1.45877401
27MP0000383_abnormal_hair_follicle1.44699801
28MP0002837_dystrophic_cardiac_calcinosis1.43756735
29MP0001486_abnormal_startle_reflex1.36884573
30MP0003635_abnormal_synaptic_transmissio1.35407061
31MP0009745_abnormal_behavioral_response1.34732381
32MP0004215_abnormal_myocardial_fiber1.34166841
33MP0003646_muscle_fatigue1.33228695
34MP0000647_abnormal_sebaceous_gland1.28598242
35MP0002063_abnormal_learning/memory/cond1.28040109
36MP0002751_abnormal_autonomic_nervous1.26719611
37MP0002557_abnormal_social/conspecific_i1.25590700
38MP0004147_increased_porphyrin_level1.25532718
39MP0002184_abnormal_innervation1.25111875
40MP0002102_abnormal_ear_morphology1.24465989
41MP0002067_abnormal_sensory_capabilities1.23768611
42MP0000372_irregular_coat_pigmentation1.21540988
43MP0002572_abnormal_emotion/affect_behav1.21146796
44MP0000427_abnormal_hair_cycle1.20510155
45MP0002733_abnormal_thermal_nociception1.18681383
46MP0002332_abnormal_exercise_endurance1.17784854
47MP0005620_abnormal_muscle_contractility1.17247702
48MP0003122_maternal_imprinting1.17095760
49MP0002736_abnormal_nociception_after1.14948314
50MP0010386_abnormal_urinary_bladder1.14633816
51MP0008775_abnormal_heart_ventricle1.14545413
52MP0001968_abnormal_touch/_nociception1.12975739
53MP0004084_abnormal_cardiac_muscle1.12588348
54MP0001299_abnormal_eye_distance/1.10520064
55MP0002272_abnormal_nervous_system1.10154579
56MP0003121_genomic_imprinting1.10025650
57MP0004085_abnormal_heartbeat1.08041695
58MP0001970_abnormal_pain_threshold1.06031759
59MP0002064_seizures1.04376895
60MP0004036_abnormal_muscle_relaxation1.03475312
61MP0000013_abnormal_adipose_tissue1.02547026
62MP0004130_abnormal_muscle_cell1.01720964
63MP0002106_abnormal_muscle_physiology1.00484250
64MP0004134_abnormal_chest_morphology0.98963875
65MP0002269_muscular_atrophy0.97711178
66MP0000778_abnormal_nervous_system0.97670254
67MP0003045_fibrosis0.97657053
68MP0000639_abnormal_adrenal_gland0.93896983
69MP0001905_abnormal_dopamine_level0.93350262
70MP0001986_abnormal_taste_sensitivity0.92029606
71MP0005187_abnormal_penis_morphology0.91164562
72MP0004811_abnormal_neuron_physiology0.86210542
73MP0005646_abnormal_pituitary_gland0.85822305
74MP0002876_abnormal_thyroid_physiology0.84051315
75MP0001984_abnormal_olfaction0.83702311
76MP0000955_abnormal_spinal_cord0.83420471
77MP0005075_abnormal_melanosome_morpholog0.83205755
78MP0005379_endocrine/exocrine_gland_phen0.82894937
79MP0000750_abnormal_muscle_regeneration0.82140397
80MP0000015_abnormal_ear_pigmentation0.81667272
81MP0002127_abnormal_cardiovascular_syste0.81178976
82MP0005266_abnormal_metabolism0.80525848
83MP0003868_abnormal_feces_composition0.80315159
84MP0002882_abnormal_neuron_morphology0.79471891
85MP0004087_abnormal_muscle_fiber0.79326992
86MP0003937_abnormal_limbs/digits/tail_de0.78409100
87MP0003221_abnormal_cardiomyocyte_apopto0.77623748
88MP0001963_abnormal_hearing_physiology0.77447609
89MP0002752_abnormal_somatic_nervous0.77053785
90MP0008770_decreased_survivor_rate0.76681820
91MP0005369_muscle_phenotype0.75991467
92MP0002168_other_aberrant_phenotype0.75594900
93MP0005253_abnormal_eye_physiology0.74556009
94MP0003195_calcinosis0.74427638
95MP0005248_abnormal_Harderian_gland0.73034966
96MP0002177_abnormal_outer_ear0.72435801
97MP0003137_abnormal_impulse_conducting0.72011727
98MP0000759_abnormal_skeletal_muscle0.71985589
99MP0002234_abnormal_pharynx_morphology0.69212456
100MP0001661_extended_life_span0.68502332

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.38399271
2Abnormality of macular pigmentation (HP:0008002)5.11943106
3Hepatoblastoma (HP:0002884)5.09219174
4Central scotoma (HP:0000603)4.72990131
5Severe visual impairment (HP:0001141)4.70115917
6Aplasia/Hypoplasia of the fovea (HP:0008060)4.67054058
7Hypoplasia of the fovea (HP:0007750)4.67054058
8Hyperventilation (HP:0002883)4.32813446
9Abnormality of the fovea (HP:0000493)4.31901219
10Albinism (HP:0001022)3.68188658
11Aplasia/Hypoplasia of the macula (HP:0008059)3.50740494
12Abnormal rod and cone electroretinograms (HP:0008323)3.45043751
13Nemaline bodies (HP:0003798)3.28930998
14Broad-based gait (HP:0002136)3.21784970
15Aplasia/Hypoplasia affecting the retina (HP:0008061)3.21459503
16Progressive cerebellar ataxia (HP:0002073)3.21437008
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.17324114
18Long clavicles (HP:0000890)3.15301144
19Muscle fiber inclusion bodies (HP:0100299)3.12275928
20Abnormality of the labia minora (HP:0012880)3.09862523
21Renal cortical cysts (HP:0000803)3.06034701
22Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.91926436
23Short phalanx of the thumb (HP:0009660)2.80462944
24Short 1st metacarpal (HP:0010034)2.79087024
25Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.79087024
26Abnormality of the renal cortex (HP:0011035)2.78151736
27Febrile seizures (HP:0002373)2.72310891
28Drooling (HP:0002307)2.53894254
29Hypoplastic labia majora (HP:0000059)2.52196801
30Decreased lacrimation (HP:0000633)2.50142209
31Scotoma (HP:0000575)2.49948689
32Protruding tongue (HP:0010808)2.49809707
33Exercise-induced muscle cramps (HP:0003710)2.45062134
34Absent speech (HP:0001344)2.43318008
35Abnormality of the 1st metacarpal (HP:0010009)2.39624160
36Increased density of long bones (HP:0006392)2.38992860
37Abnormality of the labia majora (HP:0012881)2.36054010
38Aplasia/Hypoplasia of the sternum (HP:0006714)2.35368177
39Labial hypoplasia (HP:0000066)2.35351009
40Alacrima (HP:0000522)2.35044134
41Hypsarrhythmia (HP:0002521)2.32729017
42Abnormality of the pubic bones (HP:0003172)2.32474595
43EEG with generalized epileptiform discharges (HP:0011198)2.28994464
44Bicornuate uterus (HP:0000813)2.28074367
45Excessive salivation (HP:0003781)2.28069902
46Pachygyria (HP:0001302)2.26049148
47Epileptiform EEG discharges (HP:0011182)2.24666165
48Hypoplastic nipples (HP:0002557)2.20757753
49Fair hair (HP:0002286)2.16568137
50Neoplasm of the heart (HP:0100544)2.16131014
51Genetic anticipation (HP:0003743)2.12833392
52Focal seizures (HP:0007359)2.12265377
53Medial flaring of the eyebrow (HP:0010747)2.10472026
54Generalized hypopigmentation (HP:0007513)2.10384716
55Hypothermia (HP:0002045)2.10228536
56Proximal amyotrophy (HP:0007126)2.06078093
57Frequent falls (HP:0002359)2.04569788
58Calf muscle hypertrophy (HP:0008981)2.04367050
59Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.98858685
60Distal arthrogryposis (HP:0005684)1.97950952
61Inability to walk (HP:0002540)1.97264838
62Abnormality of the calf musculature (HP:0001430)1.95953721
63Hypoplastic female external genitalia (HP:0012815)1.95432043
64Pancreatic cysts (HP:0001737)1.95360789
65Hypoglycemic coma (HP:0001325)1.94790489
66Type 1 muscle fiber predominance (HP:0003803)1.94464196
67Lissencephaly (HP:0001339)1.94208108
68Aplasia/Hypoplasia of the tibia (HP:0005772)1.93884511
69Decreased muscle mass (HP:0003199)1.93059260
70Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.92115409
71Muscle hypertrophy of the lower extremities (HP:0008968)1.92057026
72Oligomenorrhea (HP:0000876)1.91510610
73Widely spaced teeth (HP:0000687)1.90932209
74Nephronophthisis (HP:0000090)1.89835944
75Polyphagia (HP:0002591)1.89405279
76Tubulointerstitial nephritis (HP:0001970)1.88347207
77Gait imbalance (HP:0002141)1.88223116
78Proximal tubulopathy (HP:0000114)1.87994685
79Difficulty running (HP:0009046)1.86847192
80Rimmed vacuoles (HP:0003805)1.85686805
81Abnormality of the metopic suture (HP:0005556)1.85524584
82Generalized aminoaciduria (HP:0002909)1.83067031
83Pancreatic fibrosis (HP:0100732)1.82342118
84Blue irides (HP:0000635)1.80747929
85EMG: neuropathic changes (HP:0003445)1.79845074
86Exotropia (HP:0000577)1.79142205
87Broad alveolar ridges (HP:0000187)1.78805801
88Chronic hepatic failure (HP:0100626)1.77975142
89Scrotal hypoplasia (HP:0000046)1.77603278
90Focal motor seizures (HP:0011153)1.77590578
91Abnormality of the renal medulla (HP:0100957)1.75663645
92Intestinal atresia (HP:0011100)1.75419177
93Congenital primary aphakia (HP:0007707)1.74670500
94Poor eye contact (HP:0000817)1.74316450
95Thyroid-stimulating hormone excess (HP:0002925)1.73879166
96Exercise-induced myalgia (HP:0003738)1.72614695
97Cerebellar dysplasia (HP:0007033)1.71064858
98Bifid tongue (HP:0010297)1.71041909
99Confusion (HP:0001289)1.70868636
100Postaxial hand polydactyly (HP:0001162)1.69379977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.79718320
2MAP4K24.74102778
3OBSCN4.29885319
4FRK4.20313577
5MARK13.55626959
6CASK2.32704316
7MAPK132.20372731
8PHKG12.14671193
9PHKG22.14671193
10DAPK22.05860867
11MAP3K42.04869384
12WNK31.85883013
13CSNK1A1L1.80484513
14ACVR1B1.54211510
15BRD41.49518115
16CAMK1D1.46566091
17CSNK1G21.41341899
18MAP3K71.37671760
19CAMK1G1.35627163
20CSNK1G11.34239505
21CSNK1G31.33813809
22PAK31.31166401
23AKT31.31059440
24MARK31.30138396
25EPHA41.28816039
26FER1.27142219
27MET1.25720326
28BCR1.19839968
29TAOK31.16762648
30MAP2K71.13285591
31ERBB31.12345524
32NTRK31.10593689
33PTK2B1.07392495
34TRPM71.01868296
35BMPR1B0.98679538
36KSR10.96773416
37TNIK0.93140056
38GRK10.91669554
39CDC42BPA0.87259622
40CAMK2B0.86041621
41CCNB10.84323931
42BLK0.83118432
43NTRK20.82125398
44ADRBK20.81682990
45CAMK2D0.80468114
46PRKAA20.78999797
47SGK20.78698081
48STK110.76833619
49MAPKAPK30.72494604
50DYRK20.72319010
51PRKCE0.71779453
52PIK3CA0.71553881
53CAMKK20.71007851
54MAP2K40.66503520
55CAMK2A0.64912545
56CAMK2G0.63175025
57PRKG10.63075214
58PKN10.61988150
59PRKACA0.61960214
60PRKCZ0.61346432
61ROCK10.60362646
62SGK2230.60175306
63SGK4940.60175306
64CAMK10.59557354
65OXSR10.57865892
66PRKACB0.57474471
67PRKAA10.54515597
68SIK20.54379425
69CDK50.51396765
70CSNK1D0.50960080
71GRK70.50924756
72DYRK30.46241341
73INSRR0.44711719
74CSNK1A10.44288837
75CAMK40.43939255
76SGK30.41639877
77DYRK1B0.40733405
78PIK3CG0.38821579
79STK38L0.38796292
80MAPK70.37052148
81LIMK10.36861432
82PRKCG0.36655330
83PRKCB0.36405235
84RPS6KA30.36353524
85DYRK1A0.35378976
86SGK10.33956404
87MAP3K60.33920910
88MATK0.33358129
89MYLK0.32948664
90MARK20.32155475
91EPHA30.31126552
92BCKDK0.30446339
93PAK60.29131743
94CHUK0.29118286
95CSNK1E0.28471151
96TTN0.28388628
97MAPK110.28273117
98ADRBK10.27675738
99ZAK0.27564874
100PNCK0.26492840

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.03429497
2Nicotine addiction_Homo sapiens_hsa050332.53996468
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53680956
4Butanoate metabolism_Homo sapiens_hsa006502.32060870
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.28849107
6GABAergic synapse_Homo sapiens_hsa047272.19412962
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.18582228
8Morphine addiction_Homo sapiens_hsa050322.08396062
9Insulin secretion_Homo sapiens_hsa049112.07076467
10Taste transduction_Homo sapiens_hsa047422.03522074
11Dilated cardiomyopathy_Homo sapiens_hsa054142.01405553
12Fatty acid biosynthesis_Homo sapiens_hsa000611.97878315
13Renin secretion_Homo sapiens_hsa049241.91761327
14Propanoate metabolism_Homo sapiens_hsa006401.89002022
15Circadian entrainment_Homo sapiens_hsa047131.85855559
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.78202442
17Serotonergic synapse_Homo sapiens_hsa047261.76122833
18Glutamatergic synapse_Homo sapiens_hsa047241.72062955
19Calcium signaling pathway_Homo sapiens_hsa040201.63796988
20Cholinergic synapse_Homo sapiens_hsa047251.58585526
21Circadian rhythm_Homo sapiens_hsa047101.57833182
22Dopaminergic synapse_Homo sapiens_hsa047281.56710473
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56442768
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54112644
25Nitrogen metabolism_Homo sapiens_hsa009101.48080836
26Cardiac muscle contraction_Homo sapiens_hsa042601.46311011
27Axon guidance_Homo sapiens_hsa043601.43186124
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40431110
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36226310
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34407912
31Salivary secretion_Homo sapiens_hsa049701.33128443
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.29923471
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.26751152
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26744727
35beta-Alanine metabolism_Homo sapiens_hsa004101.24400483
36Phototransduction_Homo sapiens_hsa047441.20904986
37Amphetamine addiction_Homo sapiens_hsa050311.18834557
38Glucagon signaling pathway_Homo sapiens_hsa049221.18420798
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16120768
40Oxytocin signaling pathway_Homo sapiens_hsa049211.12769590
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11870091
42Cocaine addiction_Homo sapiens_hsa050301.11323623
43Ovarian steroidogenesis_Homo sapiens_hsa049131.08404450
44Sphingolipid metabolism_Homo sapiens_hsa006001.08131419
45Ether lipid metabolism_Homo sapiens_hsa005651.07969423
46Tight junction_Homo sapiens_hsa045301.06927875
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.05569248
48Linoleic acid metabolism_Homo sapiens_hsa005911.02877694
49Lysine degradation_Homo sapiens_hsa003101.01534634
50Regulation of autophagy_Homo sapiens_hsa041401.00813244
51Tryptophan metabolism_Homo sapiens_hsa003800.96460452
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95422889
53cAMP signaling pathway_Homo sapiens_hsa040240.93485309
54Basal transcription factors_Homo sapiens_hsa030220.91728927
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90043566
56ABC transporters_Homo sapiens_hsa020100.89381503
57Long-term depression_Homo sapiens_hsa047300.89339725
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88784659
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88221017
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.87167660
61Fatty acid metabolism_Homo sapiens_hsa012120.77468066
62Olfactory transduction_Homo sapiens_hsa047400.72986111
63TGF-beta signaling pathway_Homo sapiens_hsa043500.71193807
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70213043
65Vitamin B6 metabolism_Homo sapiens_hsa007500.70117801
66Gap junction_Homo sapiens_hsa045400.70093935
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69097998
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66298926
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64508568
70Gastric acid secretion_Homo sapiens_hsa049710.61171486
71Long-term potentiation_Homo sapiens_hsa047200.60752842
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58961640
73Adherens junction_Homo sapiens_hsa045200.57965305
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57927275
75Fat digestion and absorption_Homo sapiens_hsa049750.57212216
76Hippo signaling pathway_Homo sapiens_hsa043900.55435069
77GnRH signaling pathway_Homo sapiens_hsa049120.54834256
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53394420
79Alcoholism_Homo sapiens_hsa050340.51081475
80ECM-receptor interaction_Homo sapiens_hsa045120.50709551
81PPAR signaling pathway_Homo sapiens_hsa033200.45924977
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45364533
83Peroxisome_Homo sapiens_hsa041460.44892595
84Mineral absorption_Homo sapiens_hsa049780.42990648
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41351697
86Steroid biosynthesis_Homo sapiens_hsa001000.40140144
87Alzheimers disease_Homo sapiens_hsa050100.39959167
88Arginine biosynthesis_Homo sapiens_hsa002200.39072646
89MAPK signaling pathway_Homo sapiens_hsa040100.37703442
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36925588
91Inositol phosphate metabolism_Homo sapiens_hsa005620.36657494
92Histidine metabolism_Homo sapiens_hsa003400.36639904
93Caffeine metabolism_Homo sapiens_hsa002320.35353343
94Arachidonic acid metabolism_Homo sapiens_hsa005900.33844627
95Fatty acid degradation_Homo sapiens_hsa000710.33741333
96Hedgehog signaling pathway_Homo sapiens_hsa043400.32443752
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31623305
98RNA degradation_Homo sapiens_hsa030180.29643347
99Wnt signaling pathway_Homo sapiens_hsa043100.28958586
100Pancreatic secretion_Homo sapiens_hsa049720.28270851

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