ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.52838862
2	DNA deamination (GO:0045006)	5.40439694
3	fucose catabolic process (GO:0019317)	4.53294404
4	L-fucose metabolic process (GO:0042354)	4.53294404
5	L-fucose catabolic process (GO:0042355)	4.53294404
6	response to pheromone (GO:0019236)	4.48077166
7	platelet dense granule organization (GO:0060155)	4.15871159
8	cytidine deamination (GO:0009972)	4.12965553
9	cytidine metabolic process (GO:0046087)	4.12965553
10	cytidine catabolic process (GO:0006216)	4.12965553
11	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.98601065
12	cellular ketone body metabolic process (GO:0046950)	3.97248011
13	ketone body metabolic process (GO:1902224)	3.82568145
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.81571199
15	protein complex biogenesis (GO:0070271)	3.68573602
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.62097943
17	epithelial cilium movement (GO:0003351)	3.59404869
18	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.59026966
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.56656999
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.56656999
21	NADH dehydrogenase complex assembly (GO:0010257)	3.56656999
22	negative regulation of telomere maintenance (GO:0032205)	3.55415469
23	piRNA metabolic process (GO:0034587)	3.45782602
24	mitochondrial respiratory chain complex assembly (GO:0033108)	3.44959199
25	axoneme assembly (GO:0035082)	3.35657598
26	indolalkylamine metabolic process (GO:0006586)	3.32301864
27	respiratory chain complex IV assembly (GO:0008535)	3.30236110
28	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.30028635
29	protein-cofactor linkage (GO:0018065)	3.20992663
30	sulfation (GO:0051923)	3.13875913
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.10394690
32	tryptophan catabolic process (GO:0006569)	3.05649979
33	indole-containing compound catabolic process (GO:0042436)	3.05649979
34	indolalkylamine catabolic process (GO:0046218)	3.05649979
35	cytochrome complex assembly (GO:0017004)	2.98901766
36	detection of light stimulus involved in visual perception (GO:0050908)	2.95300302
37	detection of light stimulus involved in sensory perception (GO:0050962)	2.95300302
38	protein polyglutamylation (GO:0018095)	2.94185871
39	kynurenine metabolic process (GO:0070189)	2.92354206
40	preassembly of GPI anchor in ER membrane (GO:0016254)	2.89969632
41	cilium movement (GO:0003341)	2.89840578
42	kidney morphogenesis (GO:0060993)	2.88231567
43	regulation of cilium movement (GO:0003352)	2.87706460
44	retinal cone cell development (GO:0046549)	2.86660808
45	protein K6-linked ubiquitination (GO:0085020)	2.83306965
46	pseudouridine synthesis (GO:0001522)	2.82443267
47	DNA double-strand break processing (GO:0000729)	2.79700957
48	ubiquinone biosynthetic process (GO:0006744)	2.79177941
49	protein neddylation (GO:0045116)	2.75140413
50	regulation of hexokinase activity (GO:1903299)	2.70875997
51	regulation of glucokinase activity (GO:0033131)	2.70875997
52	tryptophan metabolic process (GO:0006568)	2.70686561
53	dopamine transport (GO:0015872)	2.69651466
54	mannosylation (GO:0097502)	2.69093453
55	cornea development in camera-type eye (GO:0061303)	2.68275945
56	S-adenosylmethionine metabolic process (GO:0046500)	2.68036756
57	cilium morphogenesis (GO:0060271)	2.66959020
58	nonmotile primary cilium assembly (GO:0035058)	2.65700196
59	neural tube formation (GO:0001841)	2.63765330
60	negative regulation of mast cell activation (GO:0033004)	2.63540308
61	synaptic transmission, cholinergic (GO:0007271)	2.62215368
62	DNA methylation involved in gamete generation (GO:0043046)	2.60959797
63	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.60872046
64	synapsis (GO:0007129)	2.60093766
65	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.59609419
66	ubiquinone metabolic process (GO:0006743)	2.57712798
67	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.57610300
68	positive regulation of defense response to virus by host (GO:0002230)	2.56468826
69	photoreceptor cell maintenance (GO:0045494)	2.55715605
70	peptidyl-histidine modification (GO:0018202)	2.55509420
71	ATP synthesis coupled proton transport (GO:0015986)	2.54610016
72	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.54610016
73	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.54200365
74	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.54200365
75	photoreceptor cell development (GO:0042461)	2.52748523
76	regulation of telomere maintenance (GO:0032204)	2.52333415
77	cilium organization (GO:0044782)	2.52306490
78	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.51819602
79	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.47597213
80	negative regulation by host of viral transcription (GO:0043922)	2.46063269
81	protein deneddylation (GO:0000338)	2.45374032
82	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.45187803
83	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.45187803
84	indole-containing compound metabolic process (GO:0042430)	2.45103789
85	protein K11-linked deubiquitination (GO:0035871)	2.43096013
86	protein localization to cilium (GO:0061512)	2.42997951
87	amino acid salvage (GO:0043102)	2.42970894
88	L-methionine salvage (GO:0071267)	2.42970894
89	L-methionine biosynthetic process (GO:0071265)	2.42970894
90	DNA demethylation (GO:0080111)	2.42959394
91	pyrimidine nucleobase catabolic process (GO:0006208)	2.42555998
92	aldehyde catabolic process (GO:0046185)	2.42248042
93	maturation of 5.8S rRNA (GO:0000460)	2.42178090
94	branched-chain amino acid catabolic process (GO:0009083)	2.41598198
95	cilium assembly (GO:0042384)	2.40312824
96	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.39192150
97	proteasome assembly (GO:0043248)	2.39096263
98	replication fork processing (GO:0031297)	2.39024700
99	cullin deneddylation (GO:0010388)	2.38383795
100	primary amino compound metabolic process (GO:1901160)	2.37732697

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.24819270
2	VDR_22108803_ChIP-Seq_LS180_Human	3.12689097
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.06629158
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.63077922
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.58503452
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.42940787
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.39975637
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.38592518
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.36428186
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.29571396
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.26559338
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.23043564
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.18930214
14	EZH2_22144423_ChIP-Seq_EOC_Human	2.12819299
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.11046253
16	EWS_26573619_Chip-Seq_HEK293_Human	2.06209782
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04211990
18	FUS_26573619_Chip-Seq_HEK293_Human	1.99848938
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.96863574
20	* P300_19829295_ChIP-Seq_ESCs_Human	1.94012094
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88595183
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.85875058
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.84751102
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.82467327
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.74383938
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.72226181
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.66583718
28	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.65321833
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.61545658
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.56622182
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56590253
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53477459
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.51238940
34	* BCAT_22108803_ChIP-Seq_LS180_Human	1.50303604
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48763783
36	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.47093755
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.47093755
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.47025885
39	* CBP_20019798_ChIP-Seq_JUKART_Human	1.46306407
40	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46306407
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43445680
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43445680
43	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42819619
44	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.40775762
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40557817
46	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.35979978
47	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35836256
48	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35822880
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34225046
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33060679
51	AR_25329375_ChIP-Seq_VCAP_Human	1.32141071
52	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.29391754
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28909194
54	STAT3_23295773_ChIP-Seq_U87_Human	1.28465922
55	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.28180203
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28057295
57	AR_20517297_ChIP-Seq_VCAP_Human	1.27858241
58	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27751636
59	TCF4_23295773_ChIP-Seq_U87_Human	1.26478006
60	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25693033
61	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25557087
62	* TCF4_22108803_ChIP-Seq_LS180_Human	1.24033166
63	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.23577780
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23485510
65	HOXB7_26014856_ChIP-Seq_BT474_Human	1.23471614
66	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.22927996
67	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.22339125
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19477737
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17418722
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17252181
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15550442
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14557662
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14541193
74	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.14142460
75	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.14041518
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.13437071
77	* ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13423865
78	* NCOR_22424771_ChIP-Seq_293T_Human	1.12792859
79	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11182165
80	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07503643
81	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06596624
82	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.06568515
83	RNF2_27304074_Chip-Seq_NSC_Mouse	1.06328830
84	REST_21632747_ChIP-Seq_MESCs_Mouse	1.06311152
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06063591
86	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05770660
87	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.05550640
88	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05550640
89	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05452226
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05413309
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04453511
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04005696
93	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.03923170
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03746866
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03472560
96	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.02492252
97	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02054430
98	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01983404
99	* PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00232972
100	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00002823

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.32569513
2	MP0003195_calcinosis	3.20048274
3	MP0002102_abnormal_ear_morphology	2.81988035
4	MP0005551_abnormal_eye_electrophysiolog	2.40239514
5	MP0006072_abnormal_retinal_apoptosis	2.33660507
6	MP0003787_abnormal_imprinting	2.32906406
7	MP0002876_abnormal_thyroid_physiology	2.23332972
8	MP0002837_dystrophic_cardiac_calcinosis	2.19698478
9	MP0001968_abnormal_touch/_nociception	2.18380674
10	MP0005645_abnormal_hypothalamus_physiol	2.10750000
11	MP0000372_irregular_coat_pigmentation	2.04230393
12	MP0000569_abnormal_digit_pigmentation	2.00544282
13	MP0008872_abnormal_physiological_respon	1.99394555
14	MP0005253_abnormal_eye_physiology	1.98094384
15	MP0009745_abnormal_behavioral_response	1.93045050
16	MP0001984_abnormal_olfaction	1.82560351
17	MP0008875_abnormal_xenobiotic_pharmacok	1.82341378
18	MP0009046_muscle_twitch	1.81214054
19	MP0004885_abnormal_endolymph	1.80250655
20	MP0001485_abnormal_pinna_reflex	1.71383325
21	MP0005646_abnormal_pituitary_gland	1.71030243
22	MP0003880_abnormal_central_pattern	1.67881303
23	MP0002938_white_spotting	1.66177281
24	MP0005075_abnormal_melanosome_morpholog	1.61322777
25	MP0002638_abnormal_pupillary_reflex	1.61019266
26	MP0002653_abnormal_ependyma_morphology	1.60601709
27	MP0004145_abnormal_muscle_electrophysio	1.59714994
28	MP0004133_heterotaxia	1.59358676
29	MP0003646_muscle_fatigue	1.57662385
30	MP0002272_abnormal_nervous_system	1.57615106
31	MP0004043_abnormal_pH_regulation	1.54338524
32	MP0001501_abnormal_sleep_pattern	1.50144394
33	MP0001529_abnormal_vocalization	1.49345661
34	MP0005174_abnormal_tail_pigmentation	1.48934684
35	MP0002736_abnormal_nociception_after	1.48352763
36	MP0000427_abnormal_hair_cycle	1.43685747
37	MP0006292_abnormal_olfactory_placode	1.43451510
38	MP0003136_yellow_coat_color	1.41407876
39	MP0006276_abnormal_autonomic_nervous	1.40463662
40	MP0002254_reproductive_system_inflammat	1.39752912
41	MP0002138_abnormal_hepatobiliary_system	1.39460239
42	MP0004142_abnormal_muscle_tone	1.39126101
43	MP0002163_abnormal_gland_morphology	1.39091706
44	MP0010386_abnormal_urinary_bladder	1.38428553
45	MP0000631_abnormal_neuroendocrine_gland	1.34229934
46	MP0005389_reproductive_system_phenotype	1.33740694
47	MP0005377_hearing/vestibular/ear_phenot	1.32247419
48	MP0003878_abnormal_ear_physiology	1.32247419
49	MP0005084_abnormal_gallbladder_morpholo	1.31250402
50	MP0001986_abnormal_taste_sensitivity	1.30765565
51	MP0001905_abnormal_dopamine_level	1.30165527
52	MP0001919_abnormal_reproductive_system	1.29210673
53	MP0001486_abnormal_startle_reflex	1.22725230
54	MP0001970_abnormal_pain_threshold	1.20369503
55	MP0004147_increased_porphyrin_level	1.20362513
56	MP0005379_endocrine/exocrine_gland_phen	1.20113266
57	MP0003011_delayed_dark_adaptation	1.19411646
58	MP0005671_abnormal_response_to	1.17357277
59	MP0002064_seizures	1.15801786
60	MP0002557_abnormal_social/conspecific_i	1.14578955
61	MP0002095_abnormal_skin_pigmentation	1.13759293
62	MP0002572_abnormal_emotion/affect_behav	1.10286921
63	MP0002735_abnormal_chemical_nociception	1.10282467
64	MP0004742_abnormal_vestibular_system	1.09635839
65	MP0002733_abnormal_thermal_nociception	1.09536236
66	MP0008775_abnormal_heart_ventricle	1.06938981
67	MP0002160_abnormal_reproductive_system	1.06163047
68	MP0004924_abnormal_behavior	1.06107037
69	MP0005386_behavior/neurological_phenoty	1.06107037
70	MP0002909_abnormal_adrenal_gland	1.04500707
71	MP0000647_abnormal_sebaceous_gland	1.04323182
72	MP0002277_abnormal_respiratory_mucosa	1.03142836
73	MP0002234_abnormal_pharynx_morphology	1.01541964
74	MP0005195_abnormal_posterior_eye	0.99055190
75	MP0008058_abnormal_DNA_repair	0.96816976
76	MP0003137_abnormal_impulse_conducting	0.95533080
77	MP0000516_abnormal_urinary_system	0.94905471
78	MP0005367_renal/urinary_system_phenotyp	0.94905471
79	MP0002928_abnormal_bile_duct	0.93850420
80	MP0002734_abnormal_mechanical_nocicepti	0.93488071
81	MP0005167_abnormal_blood-brain_barrier	0.92153113
82	MP0006036_abnormal_mitochondrial_physio	0.92108822
83	MP0003121_genomic_imprinting	0.90933456
84	MP0003718_maternal_effect	0.90173204
85	MP0003786_premature_aging	0.89889333
86	MP0008995_early_reproductive_senescence	0.89555696
87	MP0008789_abnormal_olfactory_epithelium	0.88937870
88	MP0005332_abnormal_amino_acid	0.88813550
89	MP0000538_abnormal_urinary_bladder	0.88395231
90	MP0005410_abnormal_fertilization	0.88389024
91	MP0002067_abnormal_sensory_capabilities	0.87637954
92	MP0003122_maternal_imprinting	0.86836617
93	MP0002751_abnormal_autonomic_nervous	0.85913533
94	MP0000230_abnormal_systemic_arterial	0.85676195
95	MP0001764_abnormal_homeostasis	0.84846563
96	MP0001929_abnormal_gametogenesis	0.82021086
97	MP0002693_abnormal_pancreas_physiology	0.81601866
98	MP0003186_abnormal_redox_activity	0.80669159
99	MP0002752_abnormal_somatic_nervous	0.77724083
100	MP0002210_abnormal_sex_determination	0.77085002

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.40658458
2	Abnormality of midbrain morphology (HP:0002418)	4.04004102
3	Molar tooth sign on MRI (HP:0002419)	4.04004102
4	Congenital stationary night blindness (HP:0007642)	4.03063739
5	Pancreatic fibrosis (HP:0100732)	3.95293852
6	True hermaphroditism (HP:0010459)	3.81610845
7	Type II lissencephaly (HP:0007260)	3.59185775
8	Nephronophthisis (HP:0000090)	3.37509820
9	Abolished electroretinogram (ERG) (HP:0000550)	3.14481404
10	Abnormality of the renal cortex (HP:0011035)	3.05327011
11	Pendular nystagmus (HP:0012043)	3.01709654
12	Medial flaring of the eyebrow (HP:0010747)	3.00010671
13	Abnormality of the renal medulla (HP:0100957)	2.88761524
14	Acute necrotizing encephalopathy (HP:0006965)	2.85602930
15	Mitochondrial inheritance (HP:0001427)	2.83196652
16	3-Methylglutaconic aciduria (HP:0003535)	2.80147693
17	Progressive macrocephaly (HP:0004481)	2.71530640
18	Increased CSF lactate (HP:0002490)	2.69907049
19	Abnormal drinking behavior (HP:0030082)	2.68739183
20	Polydipsia (HP:0001959)	2.68739183
21	Attenuation of retinal blood vessels (HP:0007843)	2.67276989
22	Acute encephalopathy (HP:0006846)	2.63480084
23	Chronic hepatic failure (HP:0100626)	2.61920859
24	Hypothermia (HP:0002045)	2.61693473
25	Cystic liver disease (HP:0006706)	2.55616951
26	Hyperventilation (HP:0002883)	2.55522301
27	Keratoconus (HP:0000563)	2.49667223
28	Increased corneal curvature (HP:0100692)	2.49667223
29	Congenital, generalized hypertrichosis (HP:0004540)	2.47881292
30	Tubular atrophy (HP:0000092)	2.47409848
31	Hepatocellular necrosis (HP:0001404)	2.46335693
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.42213676
33	Sclerocornea (HP:0000647)	2.37526537
34	Renal cortical cysts (HP:0000803)	2.35874597
35	Abnormal mitochondria in muscle tissue (HP:0008316)	2.35414213
36	Cerebellar dysplasia (HP:0007033)	2.34196975
37	Large for gestational age (HP:0001520)	2.33594972
38	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.31316878
39	Abnormality of alanine metabolism (HP:0010916)	2.31316878
40	Hyperalaninemia (HP:0003348)	2.31316878
41	Hepatic necrosis (HP:0002605)	2.28427738
42	Decreased central vision (HP:0007663)	2.23947971
43	Lissencephaly (HP:0001339)	2.21372869
44	Methylmalonic acidemia (HP:0002912)	2.21176566
45	Polyuria (HP:0000103)	2.19903051
46	Gait imbalance (HP:0002141)	2.18316863
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.18068091
48	Optic disc pallor (HP:0000543)	2.15842184
49	Furrowed tongue (HP:0000221)	2.15452219
50	Abnormal respiratory motile cilium morphology (HP:0005938)	2.13800348
51	Abnormal respiratory epithelium morphology (HP:0012253)	2.13800348
52	Anencephaly (HP:0002323)	2.11390217
53	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10321627
54	Inability to walk (HP:0002540)	2.09446346
55	Chorioretinal atrophy (HP:0000533)	2.08499215
56	Congenital primary aphakia (HP:0007707)	2.07922077
57	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.07696878
58	Progressive inability to walk (HP:0002505)	2.06804430
59	Congenital hepatic fibrosis (HP:0002612)	2.06361541
60	Male pseudohermaphroditism (HP:0000037)	2.04215356
61	Absent/shortened dynein arms (HP:0200106)	2.03912222
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.03912222
63	Hypomagnesemia (HP:0002917)	2.03841343
64	Abnormal biliary tract physiology (HP:0012439)	2.03071325
65	Bile duct proliferation (HP:0001408)	2.03071325
66	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.01767634
67	Intestinal atresia (HP:0011100)	2.01072619
68	Pachygyria (HP:0001302)	1.97025649
69	Lipid accumulation in hepatocytes (HP:0006561)	1.96868377
70	Abnormality of the labia minora (HP:0012880)	1.96648061
71	Abnormal ciliary motility (HP:0012262)	1.95131607
72	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.94081952
73	Thyroiditis (HP:0100646)	1.93468701
74	Increased serum lactate (HP:0002151)	1.92409681
75	Methylmalonic aciduria (HP:0012120)	1.92181660
76	Neoplasm of the adrenal cortex (HP:0100641)	1.90807512
77	Absent thumb (HP:0009777)	1.90193154
78	Severe muscular hypotonia (HP:0006829)	1.90098376
79	Asplenia (HP:0001746)	1.89917235
80	Retinal dysplasia (HP:0007973)	1.89887286
81	Gaze-evoked nystagmus (HP:0000640)	1.89832716
82	Increased hepatocellular lipid droplets (HP:0006565)	1.89783806
83	Short tibia (HP:0005736)	1.87841595
84	Nephrogenic diabetes insipidus (HP:0009806)	1.86693384
85	Ketoacidosis (HP:0001993)	1.86645903
86	Postaxial foot polydactyly (HP:0001830)	1.86155840
87	Aplasia/hypoplasia of the uterus (HP:0008684)	1.84242579
88	Fair hair (HP:0002286)	1.83081590
89	Hemiparesis (HP:0001269)	1.82938425
90	Occipital encephalocele (HP:0002085)	1.82325860
91	Genital tract atresia (HP:0001827)	1.81285067
92	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81204316
93	Abnormality of the pons (HP:0007361)	1.80564609
94	Dandy-Walker malformation (HP:0001305)	1.80128774
95	Ketosis (HP:0001946)	1.79215906
96	Abnormal urine output (HP:0012590)	1.78670491
97	Decreased circulating renin level (HP:0003351)	1.78386628
98	Lactic acidosis (HP:0003128)	1.77376390
99	Congenital sensorineural hearing impairment (HP:0008527)	1.75922712
100	Cerebral edema (HP:0002181)	1.75443617

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.12880782
2	BMPR1B	3.36239015
3	ADRBK2	3.23697020
4	WNK3	3.10504812
5	ACVR1B	2.92139178
6	MAP4K2	2.82352009
7	ZAK	2.48192348
8	GRK1	2.44261534
9	WNK4	2.44046211
10	INSRR	2.36208079
11	TLK1	2.17349976
12	TXK	2.15027298
13	NUAK1	2.03374664
14	PINK1	2.01221662
15	CASK	1.79499917
16	TRIM28	1.77482881
17	DAPK2	1.67026136
18	STK39	1.61707210
19	BCKDK	1.58851171
20	OXSR1	1.56493458
21	MAPK13	1.55350584
22	MST4	1.48515196
23	MAP3K4	1.46971444
24	TAOK3	1.42303415
25	MKNK2	1.33646041
26	EIF2AK3	1.26334128
27	TIE1	1.24338968
28	ERBB3	1.22618312
29	PLK2	1.18794849
30	MAP2K7	1.08489703
31	PHKG1	1.06305250
32	PHKG2	1.06305250
33	FGFR2	1.06064847
34	ADRBK1	1.05263846
35	TGFBR1	1.04467097
36	TNIK	1.00926545
37	DYRK2	0.97878346
38	PLK3	0.97266457
39	CSNK1G2	0.94186406
40	BCR	0.94113492
41	VRK2	0.92598910
42	PAK3	0.89941284
43	VRK1	0.89926215
44	CAMKK2	0.89122636
45	PRKCE	0.88768626
46	CSNK1G1	0.88562902
47	CSNK1G3	0.85585303
48	MARK1	0.85136904
49	BUB1	0.81190216
50	PTK2B	0.79389001
51	MUSK	0.78399808
52	PRKCG	0.76972367
53	WEE1	0.75412585
54	STK38L	0.75144688
55	MAPKAPK3	0.70341499
56	NME1	0.70074593
57	MAP2K6	0.66666237
58	BRSK2	0.64656146
59	NTRK3	0.63468466
60	PNCK	0.62960585
61	PRKCI	0.62204045
62	CSNK1A1L	0.59387407
63	MKNK1	0.58805215
64	PRKCQ	0.58171939
65	IKBKB	0.56721512
66	ITK	0.56305237
67	TSSK6	0.54659195
68	TEC	0.54299645
69	STK16	0.53383770
70	FER	0.53136980
71	PLK4	0.51900032
72	MAPK15	0.51369509
73	PKN1	0.50972926
74	PIK3CA	0.50668359
75	CAMK2A	0.48888668
76	GRK7	0.47387622
77	STK3	0.46724790
78	PLK1	0.46683159
79	MAPKAPK5	0.45653899
80	RPS6KA5	0.42382744
81	CSNK1A1	0.40378741
82	NTRK2	0.38946441
83	PRKACA	0.38601937
84	EIF2AK2	0.35584213
85	PRKCA	0.34621157
86	ATR	0.34303989
87	CSNK1D	0.32701595
88	KDR	0.32512612
89	NEK1	0.31318335
90	LIMK1	0.31227219
91	NEK2	0.31178683
92	CAMK1	0.29896613
93	GRK5	0.27906782
94	IGF1R	0.27550791
95	ABL1	0.26282203
96	CHUK	0.26224655
97	STK11	0.24705586
98	EPHA4	0.24363990
99	NLK	0.24207515
100	EPHA3	0.23865339

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.09270081
2	Protein export_Homo sapiens_hsa03060	2.77269349
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.74464686
4	Butanoate metabolism_Homo sapiens_hsa00650	2.33439862
5	Phototransduction_Homo sapiens_hsa04744	2.31258123
6	Proteasome_Homo sapiens_hsa03050	2.28344440
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.27144226
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.24324899
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.20402969
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.20027526
11	RNA polymerase_Homo sapiens_hsa03020	2.19511489
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.15723065
13	Parkinsons disease_Homo sapiens_hsa05012	2.09541469
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.05041866
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.96221918
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.91271518
17	Propanoate metabolism_Homo sapiens_hsa00640	1.88708026
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.80058383
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.78333538
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.75808757
21	Caffeine metabolism_Homo sapiens_hsa00232	1.75416115
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64604771
23	Homologous recombination_Homo sapiens_hsa03440	1.64586980
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.63817788
25	Nicotine addiction_Homo sapiens_hsa05033	1.63377448
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.56927347
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.55252291
28	Peroxisome_Homo sapiens_hsa04146	1.41801732
29	Basal transcription factors_Homo sapiens_hsa03022	1.35251192
30	Huntingtons disease_Homo sapiens_hsa05016	1.33882229
31	Alzheimers disease_Homo sapiens_hsa05010	1.29245535
32	One carbon pool by folate_Homo sapiens_hsa00670	1.27574247
33	RNA degradation_Homo sapiens_hsa03018	1.25976681
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.25650775
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.21627786
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.19568287
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.17213971
38	Type I diabetes mellitus_Homo sapiens_hsa04940	1.16766070
39	Collecting duct acid secretion_Homo sapiens_hsa04966	1.16361442
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.08839959
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.06618072
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.05019740
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05001953
44	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.04905948
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.04099823
46	Morphine addiction_Homo sapiens_hsa05032	0.94484826
47	Sulfur metabolism_Homo sapiens_hsa00920	0.93872081
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.91189142
49	Olfactory transduction_Homo sapiens_hsa04740	0.90887262
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90325535
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89706645
52	Taste transduction_Homo sapiens_hsa04742	0.89181897
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87289510
54	Cardiac muscle contraction_Homo sapiens_hsa04260	0.87041285
55	Asthma_Homo sapiens_hsa05310	0.86453504
56	Fatty acid elongation_Homo sapiens_hsa00062	0.86194130
57	Steroid biosynthesis_Homo sapiens_hsa00100	0.85919845
58	Regulation of autophagy_Homo sapiens_hsa04140	0.82966852
59	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.82558655
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81600498
61	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.81446766
62	Allograft rejection_Homo sapiens_hsa05330	0.80439615
63	Purine metabolism_Homo sapiens_hsa00230	0.79859356
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78742526
65	Rheumatoid arthritis_Homo sapiens_hsa05323	0.76858152
66	Graft-versus-host disease_Homo sapiens_hsa05332	0.76203814
67	ABC transporters_Homo sapiens_hsa02010	0.73789624
68	Non-homologous end-joining_Homo sapiens_hsa03450	0.72913722
69	Retinol metabolism_Homo sapiens_hsa00830	0.72604774
70	Insulin secretion_Homo sapiens_hsa04911	0.68440850
71	Metabolic pathways_Homo sapiens_hsa01100	0.67560838
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67470880
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66430931
74	Serotonergic synapse_Homo sapiens_hsa04726	0.66127239
75	GABAergic synapse_Homo sapiens_hsa04727	0.65436078
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63742190
77	Pyrimidine metabolism_Homo sapiens_hsa00240	0.63235195
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.62905542
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.59914911
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.54626829
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.51638179
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51471736
83	Nucleotide excision repair_Homo sapiens_hsa03420	0.51175261
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48885377
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48298309
86	Circadian entrainment_Homo sapiens_hsa04713	0.47421838
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46726093
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.46144083
89	Mineral absorption_Homo sapiens_hsa04978	0.44888656
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.43272906
91	Fatty acid degradation_Homo sapiens_hsa00071	0.42252851
92	Folate biosynthesis_Homo sapiens_hsa00790	0.42093557
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.39412313
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38259059
95	Salivary secretion_Homo sapiens_hsa04970	0.35619709
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.35349277
97	Histidine metabolism_Homo sapiens_hsa00340	0.35185152
98	RNA transport_Homo sapiens_hsa03013	0.34722478
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.33435252
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31541726

MKRN9P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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