MKS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene localizes to the basal body and is required for formation of the primary cilium in ciliated epithelial cells. Mutations in this gene result in Meckel syndrome type 1 and in Bardet-Biedl syndrome type 13. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)4.78780981
2DNA replication initiation (GO:0006270)4.74739750
3regulation of helicase activity (GO:0051095)4.27160309
4cilium movement (GO:0003341)4.17228871
5DNA strand elongation involved in DNA replication (GO:0006271)4.01262647
6DNA ligation (GO:0006266)3.97817273
7cilium or flagellum-dependent cell motility (GO:0001539)3.97111190
8nucleotide-excision repair, DNA gap filling (GO:0006297)3.96635826
9regulation of mitochondrial translation (GO:0070129)3.95692153
10DNA strand elongation (GO:0022616)3.91745875
11telomere maintenance via semi-conservative replication (GO:0032201)3.89596469
12telomere maintenance via telomere lengthening (GO:0010833)3.80306305
13telomere maintenance via recombination (GO:0000722)3.76840954
14establishment of integrated proviral latency (GO:0075713)3.74510115
15intraciliary transport (GO:0042073)3.72085403
16axoneme assembly (GO:0035082)3.70778745
17DNA unwinding involved in DNA replication (GO:0006268)3.51584452
18mitotic recombination (GO:0006312)3.50622181
19cullin deneddylation (GO:0010388)3.47777963
20intra-S DNA damage checkpoint (GO:0031573)3.44019544
21regulation of nuclear cell cycle DNA replication (GO:0033262)3.33992252
22protein deneddylation (GO:0000338)3.33588119
23RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32484652
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32484652
25DNA deamination (GO:0045006)3.28250215
26regulation of centriole replication (GO:0046599)3.23757092
27proteasome assembly (GO:0043248)3.23269331
28motile cilium assembly (GO:0044458)3.21916244
29pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21600279
30tRNA aminoacylation for protein translation (GO:0006418)3.18291244
31protein localization to kinetochore (GO:0034501)3.16846109
32negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.16534230
33regulation of cilium movement (GO:0003352)3.16050692
34telomere organization (GO:0032200)3.16006402
35somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14878768
36somatic hypermutation of immunoglobulin genes (GO:0016446)3.14878768
37telomere maintenance (GO:0000723)3.14341329
38amino acid activation (GO:0043038)3.13603330
39tRNA aminoacylation (GO:0043039)3.13603330
40mismatch repair (GO:0006298)3.11991981
41establishment of viral latency (GO:0019043)3.09113376
42nucleobase biosynthetic process (GO:0046112)3.08858275
43negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.07468723
44negative regulation of DNA-templated transcription, elongation (GO:0032785)3.07468723
45regulation of centrosome cycle (GO:0046605)3.06391303
46mitotic metaphase plate congression (GO:0007080)3.05488844
47formation of translation preinitiation complex (GO:0001731)3.04248237
48translesion synthesis (GO:0019985)3.04178948
49histone H2A acetylation (GO:0043968)3.03811009
50UTP biosynthetic process (GO:0006228)3.03711676
51kinetochore organization (GO:0051383)3.02115585
52pre-miRNA processing (GO:0031054)3.01886261
53kinetochore assembly (GO:0051382)3.01875829
54regulation of sister chromatid cohesion (GO:0007063)3.01751015
55microtubule depolymerization (GO:0007019)3.00413865
56non-recombinational repair (GO:0000726)3.00353646
57double-strand break repair via nonhomologous end joining (GO:0006303)3.00353646
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.99277966
59viral mRNA export from host cell nucleus (GO:0046784)2.98430328
60folic acid-containing compound biosynthetic process (GO:0009396)2.94786893
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94714407
62negative regulation of mRNA processing (GO:0050686)2.93426017
63regulation of double-strand break repair via homologous recombination (GO:0010569)2.93059318
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90530560
65purine nucleobase biosynthetic process (GO:0009113)2.88612218
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88139337
67centriole replication (GO:0007099)2.87503693
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86957372
69GTP biosynthetic process (GO:0006183)2.85887658
70IMP biosynthetic process (GO:0006188)2.84443383
71epithelial cilium movement (GO:0003351)2.84284644
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83992565
73pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.83410317
74regulation of gene silencing by miRNA (GO:0060964)2.83344461
75regulation of gene silencing by RNA (GO:0060966)2.83344461
76regulation of posttranscriptional gene silencing (GO:0060147)2.83344461
77DNA-dependent DNA replication (GO:0006261)2.83139626
78preassembly of GPI anchor in ER membrane (GO:0016254)2.82436548
79L-serine metabolic process (GO:0006563)2.81842916
80mRNA cleavage (GO:0006379)2.79329473
81regulation of centrosome duplication (GO:0010824)2.77904459
82C21-steroid hormone biosynthetic process (GO:0006700)2.77252723
83peptidyl-arginine omega-N-methylation (GO:0035247)2.76539656
84pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.75439567
85resolution of meiotic recombination intermediates (GO:0000712)2.74846482
86guanosine-containing compound biosynthetic process (GO:1901070)2.74558860
87GMP metabolic process (GO:0046037)2.74465628
88pyrimidine nucleotide catabolic process (GO:0006244)2.74113671
89dosage compensation (GO:0007549)2.74017099
90base-excision repair (GO:0006284)2.72986862
91DNA double-strand break processing (GO:0000729)2.71883828
92base-excision repair, AP site formation (GO:0006285)2.71525772
93ribosome biogenesis (GO:0042254)2.71468364
94DNA replication checkpoint (GO:0000076)2.70880325
95DNA geometric change (GO:0032392)2.69918045
96DNA damage response, detection of DNA damage (GO:0042769)2.69893517
97left/right axis specification (GO:0070986)2.69742371
98maturation of SSU-rRNA (GO:0030490)2.69595799
99negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69447964
100negative regulation of ligase activity (GO:0051352)2.69447964
101oxidative phosphorylation (GO:0006119)2.69262790
102CENP-A containing nucleosome assembly (GO:0034080)2.69024922
103mitotic sister chromatid segregation (GO:0000070)2.68894433
104centriole assembly (GO:0098534)2.68783849
105histone exchange (GO:0043486)2.68602973
106establishment of protein localization to mitochondrial membrane (GO:0090151)2.67336244
107protein localization to chromosome, centromeric region (GO:0071459)2.66974389
108chromatin remodeling at centromere (GO:0031055)2.65526679
109pseudouridine synthesis (GO:0001522)2.65071907
110DNA duplex unwinding (GO:0032508)2.64699726
111ribosomal small subunit assembly (GO:0000028)2.63810498
112protein complex biogenesis (GO:0070271)2.63682790
113mitochondrial respiratory chain complex assembly (GO:0033108)2.63282496
114deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.63022151
115positive regulation of developmental pigmentation (GO:0048087)2.62973846
116mitochondrial DNA replication (GO:0006264)2.62797726
117DNA replication-dependent nucleosome assembly (GO:0006335)2.62531179
118DNA replication-dependent nucleosome organization (GO:0034723)2.62531179
119metaphase plate congression (GO:0051310)2.62146184
120rRNA modification (GO:0000154)2.62124556
121replication fork processing (GO:0031297)2.61579167
122epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60798411
123NIK/NF-kappaB signaling (GO:0038061)2.60787438
124peptidyl-histidine modification (GO:0018202)2.60310004
125microtubule severing (GO:0051013)2.60268150
126chaperone-mediated protein transport (GO:0072321)2.59208520
127DNA replication-independent nucleosome assembly (GO:0006336)2.59003162
128DNA replication-independent nucleosome organization (GO:0034724)2.59003162
129postreplication repair (GO:0006301)2.58975919
130transcription-coupled nucleotide-excision repair (GO:0006283)2.56594842
131regulation of cellular amino acid metabolic process (GO:0006521)2.56536754
132positive regulation of chromosome segregation (GO:0051984)2.56533636
133telomere maintenance via telomerase (GO:0007004)2.56473246
134negative regulation of telomere maintenance (GO:0032205)2.56177478
135mitochondrial RNA metabolic process (GO:0000959)2.55662430
136microtubule bundle formation (GO:0001578)2.55179386
137sequestering of actin monomers (GO:0042989)2.54996445
138CTP metabolic process (GO:0046036)2.54755605
139CTP biosynthetic process (GO:0006241)2.54755605
140ribosome assembly (GO:0042255)2.53636367
141tRNA metabolic process (GO:0006399)2.53283729
142DNA topological change (GO:0006265)2.53133775
143positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.51897211
144pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.51896284
145negative regulation of RNA splicing (GO:0033119)2.51470901
146pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.49524216
147progesterone metabolic process (GO:0042448)2.49258642
148tRNA modification (GO:0006400)2.49007912
149UTP metabolic process (GO:0046051)2.48506575
150mitotic nuclear envelope disassembly (GO:0007077)2.48202412
151spliceosomal snRNP assembly (GO:0000387)2.44175504
152ventricular system development (GO:0021591)2.43522391
153histone H4-K12 acetylation (GO:0043983)2.43058750
154regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.42853951
155replicative senescence (GO:0090399)2.42300580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.02767678
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.53790965
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01991292
4MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74022059
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72158768
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.71500784
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.70750445
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61439585
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57804881
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53931591
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.48954255
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.46186116
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41775541
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38272939
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35454032
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34793001
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.29863876
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.17291730
19XRN2_22483619_ChIP-Seq_HELA_Human2.10628129
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07486039
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06213272
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04234970
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02971906
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02862943
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02607481
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.99608821
27VDR_23849224_ChIP-Seq_CD4+_Human1.93440745
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90508334
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.88360526
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86617070
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86302897
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85760059
33MYC_22102868_ChIP-Seq_BL_Human1.85440302
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81362257
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.76854368
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73922269
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72802132
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72657419
39AR_21909140_ChIP-Seq_LNCAP_Human1.72386243
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64868529
41* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63434651
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.60392821
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60296743
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56638240
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55911206
46* GABP_19822575_ChIP-Seq_HepG2_Human1.55817606
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55682064
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.54180284
49TTF2_22483619_ChIP-Seq_HELA_Human1.51110455
50DCP1A_22483619_ChIP-Seq_HELA_Human1.50983767
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.45751555
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45666140
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44025703
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44025703
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44025703
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43746650
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43432807
58CIITA_25753668_ChIP-Seq_RAJI_Human1.42887471
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41940209
60* FOXP3_21729870_ChIP-Seq_TREG_Human1.41456021
61MYC_18940864_ChIP-ChIP_HL60_Human1.41153071
62IRF1_19129219_ChIP-ChIP_H3396_Human1.38915635
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37575330
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.37168935
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37157456
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.36237180
67ZNF274_21170338_ChIP-Seq_K562_Hela1.34511634
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34366583
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32665652
70* KDM5A_27292631_Chip-Seq_BREAST_Human1.31214834
71NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29738938
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28860792
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27202460
74* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26054326
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25423514
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25276396
77TFEB_21752829_ChIP-Seq_HELA_Human1.24891691
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23471787
79* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23353017
80* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22059212
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18123302
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17624937
83VDR_21846776_ChIP-Seq_THP-1_Human1.16362422
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15468259
85ELK1_19687146_ChIP-ChIP_HELA_Human1.14369982
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13865965
87* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12166080
88* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10898384
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.10844042
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10828035
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.09556620
92NANOG_16153702_ChIP-ChIP_HESCs_Human1.09391620
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08348851
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07436879
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05281881
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04994322
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04752029
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03754717
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02705048
100SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02235943
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.01838579
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00888369
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00822436
104KAP1_27257070_Chip-Seq_ESCs_Mouse1.00733266
105CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99385352
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.99150879
107FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98282038
108* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97487274
109TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96208936
110EWS_26573619_Chip-Seq_HEK293_Human0.95980249
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95744800
112NANOG_21062744_ChIP-ChIP_HESCs_Human0.94916983
113TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.94487483
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93968022
115* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93640685
116CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93289488
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93169554
118IGF1R_20145208_ChIP-Seq_DFB_Human0.92843548
119SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92675113
120* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92391579
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92010425
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91987214
123FOXP1_21924763_ChIP-Seq_HESCs_Human0.89039645
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88571707
125FUS_26573619_Chip-Seq_HEK293_Human0.86785725
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85426475
127POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85343132
128NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78822013
129ELK1_22589737_ChIP-Seq_MCF10A_Human0.74559076
130SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.73391999
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72709319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.01703717
2MP0010094_abnormal_chromosome_stability3.72397491
3MP0008058_abnormal_DNA_repair3.52059017
4MP0003693_abnormal_embryo_hatching3.39303388
5MP0003111_abnormal_nucleus_morphology3.25766305
6MP0003136_yellow_coat_color3.23256166
7MP0004147_increased_porphyrin_level2.82583254
8MP0003077_abnormal_cell_cycle2.80850596
9MP0004957_abnormal_blastocyst_morpholog2.46054930
10MP0001529_abnormal_vocalization2.38382128
11MP0002653_abnormal_ependyma_morphology2.36985485
12MP0010030_abnormal_orbit_morphology2.36495387
13MP0000566_synostosis2.33009206
14MP0008007_abnormal_cellular_replicative2.31005344
15MP0005394_taste/olfaction_phenotype2.25323182
16MP0005499_abnormal_olfactory_system2.25323182
17MP0001873_stomach_inflammation2.10002833
18MP0003763_abnormal_thymus_physiology2.01198026
19* MP0004133_heterotaxia2.01190720
20MP0008875_abnormal_xenobiotic_pharmacok1.89995401
21MP0008932_abnormal_embryonic_tissue1.89797284
22MP0006292_abnormal_olfactory_placode1.86721748
23MP0000685_abnormal_immune_system1.85104764
24MP0008877_abnormal_DNA_methylation1.72197066
25MP0005075_abnormal_melanosome_morpholog1.69136017
26MP0008995_early_reproductive_senescence1.64272768
27MP0000350_abnormal_cell_proliferation1.64210103
28MP0001984_abnormal_olfaction1.63723117
29MP0000490_abnormal_crypts_of1.57209159
30MP0002396_abnormal_hematopoietic_system1.56639420
31MP0003950_abnormal_plasma_membrane1.54252459
32MP0006276_abnormal_autonomic_nervous1.54054039
33MP0003121_genomic_imprinting1.52962331
34MP0001730_embryonic_growth_arrest1.51731089
35MP0003123_paternal_imprinting1.50794089
36MP0002751_abnormal_autonomic_nervous1.49511168
37MP0002938_white_spotting1.48014724
38MP0002210_abnormal_sex_determination1.46609522
39MP0004381_abnormal_hair_follicle1.45290053
40MP0009697_abnormal_copulation1.45249036
41MP0000428_abnormal_craniofacial_morphol1.43302210
42MP0001293_anophthalmia1.41368836
43MP0002736_abnormal_nociception_after1.38763312
44MP0000647_abnormal_sebaceous_gland1.38358555
45MP0005645_abnormal_hypothalamus_physiol1.35753018
46MP0002234_abnormal_pharynx_morphology1.34990560
47MP0006036_abnormal_mitochondrial_physio1.34625373
48MP0001986_abnormal_taste_sensitivity1.32852422
49* MP0002085_abnormal_embryonic_tissue1.31540833
50MP0006035_abnormal_mitochondrial_morpho1.31005590
51MP0001929_abnormal_gametogenesis1.26972429
52MP0002102_abnormal_ear_morphology1.26616352
53MP0003186_abnormal_redox_activity1.25969537
54MP0010352_gastrointestinal_tract_polyps1.25342249
55MP0003880_abnormal_central_pattern1.24309876
56MP0005187_abnormal_penis_morphology1.22744885
57MP0000313_abnormal_cell_death1.22396645
58MP0005380_embryogenesis_phenotype1.22002898
59MP0001672_abnormal_embryogenesis/_devel1.22002898
60MP0003786_premature_aging1.21862253
61MP0008004_abnormal_stomach_pH1.21567696
62MP0005248_abnormal_Harderian_gland1.21149340
63* MP0000358_abnormal_cell_content/1.20284434
64MP0002638_abnormal_pupillary_reflex1.20070776
65MP0003718_maternal_effect1.19882014
66MP0001145_abnormal_male_reproductive1.16682256
67MP0000631_abnormal_neuroendocrine_gland1.14787357
68MP0002405_respiratory_system_inflammati1.14126828
69* MP0002084_abnormal_developmental_patter1.14099056
70MP0003122_maternal_imprinting1.13387839
71MP0001764_abnormal_homeostasis1.11413826
72MP0005671_abnormal_response_to1.10934464
73MP0001697_abnormal_embryo_size1.10172178
74MP0002019_abnormal_tumor_incidence1.10109068
75MP0004782_abnormal_surfactant_physiolog1.09284836
76MP0003937_abnormal_limbs/digits/tail_de1.08592612
77MP0005647_abnormal_sex_gland1.08177323
78MP0004197_abnormal_fetal_growth/weight/1.06827317
79MP0005551_abnormal_eye_electrophysiolog1.06102105
80MP0003984_embryonic_growth_retardation1.06099429
81MP0000703_abnormal_thymus_morphology1.05028936
82MP0000372_irregular_coat_pigmentation1.04543670
83MP0001853_heart_inflammation1.04237272
84* MP0002160_abnormal_reproductive_system1.02853959
85MP0001346_abnormal_lacrimal_gland1.02318503
86MP0002233_abnormal_nose_morphology1.02210920
87MP0008789_abnormal_olfactory_epithelium1.00938579
88MP0009333_abnormal_splenocyte_physiolog1.00490002
89MP0005387_immune_system_phenotype1.00044607
90MP0001790_abnormal_immune_system1.00044607
91* MP0002080_prenatal_lethality0.99978704
92MP0002132_abnormal_respiratory_system0.99770994
93MP0003787_abnormal_imprinting0.99395971
94MP0002088_abnormal_embryonic_growth/wei0.98809243
95MP0005670_abnormal_white_adipose0.98419864
96MP0003119_abnormal_digestive_system0.96960248
97MP0000613_abnormal_salivary_gland0.96519790
98MP0000470_abnormal_stomach_morphology0.96495360
99MP0001800_abnormal_humoral_immune0.95596986
100MP0002398_abnormal_bone_marrow0.94834069
101MP0003315_abnormal_perineum_morphology0.94827423
102* MP0000653_abnormal_sex_gland0.94542831
103MP0002822_catalepsy0.94265375
104MP0000049_abnormal_middle_ear0.94105568
105MP0002249_abnormal_larynx_morphology0.93980881
106MP0002111_abnormal_tail_morphology0.93064673
107MP0002095_abnormal_skin_pigmentation0.92867701
108MP0005171_absent_coat_pigmentation0.92660344
109MP0004134_abnormal_chest_morphology0.91682666
110MP0002282_abnormal_trachea_morphology0.91112764
111MP0006072_abnormal_retinal_apoptosis0.87760373
112MP0002722_abnormal_immune_system0.87664401
113MP0003941_abnormal_skin_development0.87335699
114MP0001727_abnormal_embryo_implantation0.87231054
115MP0003567_abnormal_fetal_cardiomyocyte0.86016630
116MP0001835_abnormal_antigen_presentation0.85883008
117MP0001286_abnormal_eye_development0.84954893
118MP0000383_abnormal_hair_follicle0.84488878
119MP0003698_abnormal_male_reproductive0.84459083
120MP0005646_abnormal_pituitary_gland0.83937657
121MP0005391_vision/eye_phenotype0.82450555
122* MP0003861_abnormal_nervous_system0.81877518
123* MP0001119_abnormal_female_reproductive0.81773496
124MP0002086_abnormal_extraembryonic_tissu0.81135778
125MP0000716_abnormal_immune_system0.80057278
126MP0002161_abnormal_fertility/fecundity0.78749296
127MP0003890_abnormal_embryonic-extraembry0.78124294
128MP0002092_abnormal_eye_morphology0.77763257
129MP0000689_abnormal_spleen_morphology0.77686769
130MP0002163_abnormal_gland_morphology0.77138321
131MP0002420_abnormal_adaptive_immunity0.75841761
132MP0005408_hypopigmentation0.74132536
133MP0001819_abnormal_immune_cell0.73933993
134MP0000537_abnormal_urethra_morphology0.73683154
135MP0010155_abnormal_intestine_physiology0.72944132
136MP0002452_abnormal_antigen_presenting0.72889528
137MP0002429_abnormal_blood_cell0.72834626
138MP0001324_abnormal_eye_pigmentation0.72508494
139MP0005377_hearing/vestibular/ear_phenot0.72271387
140MP0003878_abnormal_ear_physiology0.72271387
141MP0005636_abnormal_mineral_homeostasis0.71915864
142MP0005395_other_phenotype0.71676164
143* MP0003936_abnormal_reproductive_system0.71150995
144MP0009703_decreased_birth_body0.70513156
145MP0004043_abnormal_pH_regulation0.70380242
146MP0003806_abnormal_nucleotide_metabolis0.70361863
147MP0005253_abnormal_eye_physiology0.69854607
148MP0003938_abnormal_ear_development0.67773821

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)5.76655263
2Abnormal ciliary motility (HP:0012262)5.57390629
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.32001106
4Rhinitis (HP:0012384)4.66401194
5Male infertility (HP:0003251)4.39249264
6Abnormal respiratory epithelium morphology (HP:0012253)4.36132238
7Abnormal respiratory motile cilium morphology (HP:0005938)4.36132238
8Nasal polyposis (HP:0100582)3.40491300
911 pairs of ribs (HP:0000878)3.39394938
10Bronchiectasis (HP:0002110)3.27967194
11Oral leukoplakia (HP:0002745)3.27788497
12Acute necrotizing encephalopathy (HP:0006965)3.26614588
13Abnormal sex determination (HP:0012244)3.24391940
14Sex reversal (HP:0012245)3.24391940
15Abnormal mitochondria in muscle tissue (HP:0008316)3.23131190
16* True hermaphroditism (HP:0010459)3.22844671
17Absent/shortened dynein arms (HP:0200106)3.21824963
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.21824963
19Abnormality of glycolysis (HP:0004366)3.16328206
20Selective tooth agenesis (HP:0001592)3.16048171
21Increased serum pyruvate (HP:0003542)3.09901407
22Acute encephalopathy (HP:0006846)3.05265790
23Chronic bronchitis (HP:0004469)3.02520353
24Hepatocellular necrosis (HP:0001404)2.96296859
25Mitochondrial inheritance (HP:0001427)2.95259776
26Broad distal phalanx of finger (HP:0009836)2.91913414
27Increased CSF lactate (HP:0002490)2.86346617
28* Supernumerary spleens (HP:0009799)2.80858883
29Microvesicular hepatic steatosis (HP:0001414)2.76742213
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72877415
31Chromsome breakage (HP:0040012)2.71459413
32Hepatic necrosis (HP:0002605)2.69301827
33Tubulointerstitial nephritis (HP:0001970)2.67275079
34* Medial flaring of the eyebrow (HP:0010747)2.59760738
35Absent radius (HP:0003974)2.58195796
36Abnormality of the dental root (HP:0006486)2.57648208
37Taurodontia (HP:0000679)2.57648208
38Abnormality of permanent molar morphology (HP:0011071)2.57648208
39Hyperglycinemia (HP:0002154)2.55758883
40Progressive macrocephaly (HP:0004481)2.53874037
41Abdominal situs inversus (HP:0003363)2.53639093
42Abnormality of abdominal situs (HP:0011620)2.53639093
43Lipid accumulation in hepatocytes (HP:0006561)2.52827828
44Abnormality of the nasal mucosa (HP:0000433)2.52736314
45Aplasia involving forearm bones (HP:0009822)2.51848458
46Absent forearm bone (HP:0003953)2.51848458
47Increased hepatocellular lipid droplets (HP:0006565)2.46917356
48Abnormal gallbladder physiology (HP:0012438)2.43454243
49Cholecystitis (HP:0001082)2.43454243
50* Congenital primary aphakia (HP:0007707)2.42923445
51* Male pseudohermaphroditism (HP:0000037)2.40352663
52Reticulocytopenia (HP:0001896)2.40147124
53Fibular hypoplasia (HP:0003038)2.39444780
54Facial cleft (HP:0002006)2.38557502
55Median cleft lip (HP:0000161)2.36418457
56Abnormality of molar (HP:0011077)2.35849859
57Abnormality of molar morphology (HP:0011070)2.35849859
58Cerebral edema (HP:0002181)2.35743564
59Abnormality of the fingertips (HP:0001211)2.30541991
60Recurrent sinusitis (HP:0011108)2.29056772
61Duplicated collecting system (HP:0000081)2.26963380
62Missing ribs (HP:0000921)2.26532170
63Increased serum lactate (HP:0002151)2.25441387
64Duplication of thumb phalanx (HP:0009942)2.23371391
65* Gait imbalance (HP:0002141)2.22775168
66Premature graying of hair (HP:0002216)2.22515717
67Aplasia/Hypoplasia of the sternum (HP:0006714)2.21378987
68Abnormality of the dental pulp (HP:0006479)2.20921119
69Abnormality of DNA repair (HP:0003254)2.20604560
70Bronchitis (HP:0012387)2.19775272
71* Postaxial foot polydactyly (HP:0001830)2.19584364
72Abnormal number of erythroid precursors (HP:0012131)2.19104894
73* Asplenia (HP:0001746)2.18885052
74Bone marrow hypocellularity (HP:0005528)2.18882520
75Rough bone trabeculation (HP:0100670)2.18252812
76* Nephrogenic diabetes insipidus (HP:0009806)2.17197445
77Abnormality of dentin (HP:0010299)2.16610739
78Abnormality of the labia minora (HP:0012880)2.15049586
79Ependymoma (HP:0002888)2.14233429
80Abnormality of the renal medulla (HP:0100957)2.14003466
81Medulloblastoma (HP:0002885)2.12150748
82Abnormal number of incisors (HP:0011064)2.11477769
83Abnormality of the renal collecting system (HP:0004742)2.11069065
84Colon cancer (HP:0003003)2.10213197
85* Pancreatic cysts (HP:0001737)2.08833757
86* Aplasia/Hypoplasia of the tongue (HP:0010295)2.08780680
87* Sloping forehead (HP:0000340)2.08690026
88* Pancreatic fibrosis (HP:0100732)2.08601934
89Abnormality of the ileum (HP:0001549)2.07117793
90Hemivertebrae (HP:0002937)2.06143028
91Aplasia/Hypoplasia of the uvula (HP:0010293)2.04710852
92Horseshoe kidney (HP:0000085)2.04381553
93Postnatal microcephaly (HP:0005484)2.04146048
94Lactic acidosis (HP:0003128)2.04019454
95Birth length less than 3rd percentile (HP:0003561)2.03699745
96Degeneration of the lateral corticospinal tracts (HP:0002314)2.03645957
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03645957
98Chronic sinusitis (HP:0011109)2.03221007
99* Occipital encephalocele (HP:0002085)2.03139094
100* Sclerocornea (HP:0000647)2.03058670
101Hyperglycinuria (HP:0003108)2.02880458
102* Preaxial hand polydactyly (HP:0001177)2.02193233
103* Hypotelorism (HP:0000601)1.99305426
104Chronic hepatic failure (HP:0100626)1.99228441
105Abnormality of serine family amino acid metabolism (HP:0010894)1.96371788
106Abnormality of glycine metabolism (HP:0010895)1.96371788
107Optic nerve coloboma (HP:0000588)1.95957340
108Meckel diverticulum (HP:0002245)1.95348527
109* Aplasia/Hypoplasia of the spleen (HP:0010451)1.94821048
110Exercise intolerance (HP:0003546)1.94700324
111Rib fusion (HP:0000902)1.94653417
112Increased intramyocellular lipid droplets (HP:0012240)1.91344899
113* Aganglionic megacolon (HP:0002251)1.91098278
114Respiratory failure (HP:0002878)1.90871752
115Ectopic kidney (HP:0000086)1.90308128
116* Postaxial hand polydactyly (HP:0001162)1.87949674
117* Oculomotor apraxia (HP:0000657)1.87648732
118Cellular immunodeficiency (HP:0005374)1.86007299
119CNS hypomyelination (HP:0003429)1.84784229
120Septo-optic dysplasia (HP:0100842)1.83221454
1213-Methylglutaconic aciduria (HP:0003535)1.82857159
122Abnormal protein N-linked glycosylation (HP:0012347)1.82138460
123Abnormal protein glycosylation (HP:0012346)1.82138460
124Abnormal glycosylation (HP:0012345)1.82138460
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82138460
126* Anencephaly (HP:0002323)1.81688846
127Infertility (HP:0000789)1.81407489
128Short tibia (HP:0005736)1.81274330
129Aplasia/Hypoplasia of the fibula (HP:0006492)1.79670998
130Tracheoesophageal fistula (HP:0002575)1.79538662
131Cortical dysplasia (HP:0002539)1.79388520
132Abnormality of cells of the erythroid lineage (HP:0012130)1.78611740
133Back pain (HP:0003418)1.77171650
134Nephroblastoma (Wilms tumor) (HP:0002667)1.76892485
135Ectopic anus (HP:0004397)1.76259350
136Abnormality of the preputium (HP:0100587)1.76100522
137Molar tooth sign on MRI (HP:0002419)1.74940980
138Abnormality of midbrain morphology (HP:0002418)1.74940980
139Patellar aplasia (HP:0006443)1.74538840
140Neoplasm of the pancreas (HP:0002894)1.73454784
141Abnormality of chromosome stability (HP:0003220)1.71984456
142Small intestinal stenosis (HP:0012848)1.71144256
143Duodenal stenosis (HP:0100867)1.71144256
144Genetic anticipation (HP:0003743)1.71027749
145Urethral obstruction (HP:0000796)1.70715626
146Increased nuchal translucency (HP:0010880)1.69974830
147Maternal diabetes (HP:0009800)1.69741392
148Triphalangeal thumb (HP:0001199)1.69583009
149Lethargy (HP:0001254)1.68983805
150Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68698644
151Broad alveolar ridges (HP:0000187)1.67769249
152* Poor coordination (HP:0002370)1.67430518
153CNS demyelination (HP:0007305)1.67374093
154* Genital tract atresia (HP:0001827)1.67304843
155Increased muscle lipid content (HP:0009058)1.67302116
156Type I transferrin isoform profile (HP:0003642)1.66709287
157* Broad foot (HP:0001769)1.66543370
158* Cystic liver disease (HP:0006706)1.66462687
159Microretrognathia (HP:0000308)1.66034035
160* Vaginal atresia (HP:0000148)1.65535995
161Breast hypoplasia (HP:0003187)1.65259644
162Abnormality of serum amino acid levels (HP:0003112)1.64684547
163Recurrent bronchitis (HP:0002837)1.64611884
164Nephronophthisis (HP:0000090)1.64285437
165Cerebral hypomyelination (HP:0006808)1.61592946
166IgM deficiency (HP:0002850)1.59645793
167* Congenital hepatic fibrosis (HP:0002612)1.58029174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.82042034
2VRK23.74963092
3WEE13.28939030
4EIF2AK13.11972481
5MST42.65462858
6MAPK152.60363656
7MAP4K22.59492156
8CDC72.49908036
9BRD42.42810282
10CDK122.26233724
11PASK2.25870322
12TTK2.06954590
13PLK42.02083125
14GRK12.00842493
15NEK21.94442062
16TSSK61.82067799
17MAP3K101.81235594
18RPS6KB21.80704369
19ERBB31.78263365
20EEF2K1.76528774
21ATR1.75226672
22BCKDK1.60470813
23EPHA21.59664427
24CDK41.59106315
25CHEK21.57115866
26DYRK31.53484832
27CDK71.51668647
28PDK21.50686149
29PLK11.50402908
30BRSK21.50339641
31TRIM281.49835212
32MAP4K11.49213451
33ZAK1.45645207
34NEK11.43934919
35PNCK1.42457350
36CASK1.39985899
37PIM21.35398397
38STK161.30359234
39NUAK11.27316137
40WNK31.27211537
41STK101.25364366
42MKNK11.24968485
43CCNB11.24884763
44DYRK21.23740310
45BTK1.23307940
46MAP2K71.23177196
47VRK11.22620627
48BMPR21.20601986
49PAK41.20212692
50AURKA1.19038815
51CDK81.15418858
52CHEK11.14107900
53BCR1.13419173
54PLK21.12266174
55AURKB1.09588079
56MAP3K41.09076555
57PLK31.08542351
58NME21.07605379
59CSNK1G21.03915578
60IRAK41.03878417
61EIF2AK31.03057584
62CDC42BPA1.01538563
63NEK60.99491377
64ITK0.97464521
65NME10.96620430
66BMPR1B0.91839963
67PIM10.91087714
68TXK0.90848770
69CDK60.87045142
70TESK20.86439129
71KDR0.83650371
72CSNK1A1L0.82115978
73TEC0.81254123
74IRAK10.79938491
75CDK20.79453962
76ERBB40.77730487
77TRPM70.77014936
78STK40.76834272
79SRPK10.76148101
80CDK190.75418941
81ATM0.74599666
82IRAK30.72778295
83PINK10.72679363
84TNIK0.72404449
85YES10.70393479
86EIF2AK20.69652237
87MKNK20.69093711
88TESK10.67771660
89BRSK10.65222381
90RPS6KA40.64645400
91TGFBR10.63221504
92RPS6KA50.63012833
93MAPKAPK30.61743093
94ACVR1B0.61544761
95FGFR10.61499768
96MTOR0.61219763
97MELK0.61061530
98JAK30.59396231
99PBK0.59376938
100TLK10.58445238
101CSNK2A20.58097078
102CDK10.57871334
103ICK0.57621918
104CSNK1G30.57434551
105CDK30.56927637
106MAPKAPK50.56499948
107CLK10.55979597
108IRAK20.54749422
109MAPK110.54266754
110CDK90.53952225
111CHUK0.53643995
112TYK20.52673155
113AKT20.52587863
114IKBKB0.52143012
115TAF10.51339186
116SMG10.50635555
117FER0.48860069
118MAPK70.48000682
119PAK10.47511521
120CSNK2A10.46599248
121CSNK1G10.45259125
122STK38L0.44940114
123MAP3K80.44338903
124PRKCI0.43779245
125MAPKAPK20.43249714
126CSNK1D0.42680756
127PRKDC0.42644818
128WNK40.40305382
129CSNK1E0.37603830
130DAPK10.36684208
131CSNK1A10.35613952
132LRRK20.34144532
133MST1R0.31900278
134MAPK130.30999017
135ALK0.30122924
136PRKACB0.27586631
137SCYL20.25432123
138MINK10.24237466
139MET0.21228705
140PRKCG0.20799776

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.52821477
2Mismatch repair_Homo sapiens_hsa034304.50918654
3Base excision repair_Homo sapiens_hsa034103.71206455
4Nucleotide excision repair_Homo sapiens_hsa034202.99622658
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98236768
6Homologous recombination_Homo sapiens_hsa034402.97043309
7Fanconi anemia pathway_Homo sapiens_hsa034602.89029386
8Spliceosome_Homo sapiens_hsa030402.80500182
9RNA polymerase_Homo sapiens_hsa030202.37363371
10RNA transport_Homo sapiens_hsa030132.37143069
11One carbon pool by folate_Homo sapiens_hsa006702.36503835
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30303125
13Cell cycle_Homo sapiens_hsa041102.26367688
14Proteasome_Homo sapiens_hsa030502.17016307
15Pyrimidine metabolism_Homo sapiens_hsa002402.12506055
16Non-homologous end-joining_Homo sapiens_hsa034502.11701242
17Ribosome_Homo sapiens_hsa030102.04470306
18Oxidative phosphorylation_Homo sapiens_hsa001901.91307535
19Fatty acid elongation_Homo sapiens_hsa000621.87972082
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85855281
21Basal transcription factors_Homo sapiens_hsa030221.83628662
22RNA degradation_Homo sapiens_hsa030181.82622729
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.80731242
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78568821
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78296170
26Parkinsons disease_Homo sapiens_hsa050121.76602018
27Propanoate metabolism_Homo sapiens_hsa006401.75403615
28mRNA surveillance pathway_Homo sapiens_hsa030151.75295609
29Steroid biosynthesis_Homo sapiens_hsa001001.62541233
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57272120
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55745294
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55572852
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54487913
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53688669
35Notch signaling pathway_Homo sapiens_hsa043301.47124879
36Primary immunodeficiency_Homo sapiens_hsa053401.46603152
37Pyruvate metabolism_Homo sapiens_hsa006201.44503312
38Carbon metabolism_Homo sapiens_hsa012001.37348830
39p53 signaling pathway_Homo sapiens_hsa041151.36902555
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36369740
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35627030
42Antigen processing and presentation_Homo sapiens_hsa046121.27411494
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23647633
44Basal cell carcinoma_Homo sapiens_hsa052171.17505423
45Purine metabolism_Homo sapiens_hsa002301.14175353
46Herpes simplex infection_Homo sapiens_hsa051681.13529891
47Fatty acid metabolism_Homo sapiens_hsa012121.12608772
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.10909642
49Epstein-Barr virus infection_Homo sapiens_hsa051691.10246665
50Butanoate metabolism_Homo sapiens_hsa006501.09945749
51Peroxisome_Homo sapiens_hsa041461.05662230
52HTLV-I infection_Homo sapiens_hsa051661.01788034
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00943976
54Sulfur relay system_Homo sapiens_hsa041221.00372610
55Allograft rejection_Homo sapiens_hsa053300.97383438
56Alzheimers disease_Homo sapiens_hsa050100.93026884
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92259231
58Metabolic pathways_Homo sapiens_hsa011000.87841943
59Hippo signaling pathway_Homo sapiens_hsa043900.85988314
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84863707
61Hedgehog signaling pathway_Homo sapiens_hsa043400.84481822
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84048075
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82568840
64Asthma_Homo sapiens_hsa053100.81339999
65Phenylalanine metabolism_Homo sapiens_hsa003600.80199471
66Viral carcinogenesis_Homo sapiens_hsa052030.80063056
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76912284
68beta-Alanine metabolism_Homo sapiens_hsa004100.76701039
69Vitamin B6 metabolism_Homo sapiens_hsa007500.76112716
70Measles_Homo sapiens_hsa051620.76008438
71Tyrosine metabolism_Homo sapiens_hsa003500.72207911
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70727048
73Graft-versus-host disease_Homo sapiens_hsa053320.69451876
74Autoimmune thyroid disease_Homo sapiens_hsa053200.69230525
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68797725
76TGF-beta signaling pathway_Homo sapiens_hsa043500.67715295
77Oocyte meiosis_Homo sapiens_hsa041140.67587092
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65919277
79Fatty acid degradation_Homo sapiens_hsa000710.65475626
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64484931
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63996411
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62964102
83Apoptosis_Homo sapiens_hsa042100.61178611
84Hematopoietic cell lineage_Homo sapiens_hsa046400.59518546
85Other glycan degradation_Homo sapiens_hsa005110.59011871
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58324491
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.57359886
88Protein export_Homo sapiens_hsa030600.56764070
89Small cell lung cancer_Homo sapiens_hsa052220.55615387
90Biosynthesis of amino acids_Homo sapiens_hsa012300.54856272
91Folate biosynthesis_Homo sapiens_hsa007900.54778367
92Phototransduction_Homo sapiens_hsa047440.54571753
93Glutathione metabolism_Homo sapiens_hsa004800.52894002
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52814734
95MicroRNAs in cancer_Homo sapiens_hsa052060.52147489
96Systemic lupus erythematosus_Homo sapiens_hsa053220.49961244
97Chemical carcinogenesis_Homo sapiens_hsa052040.49165979
98Viral myocarditis_Homo sapiens_hsa054160.48663707
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48588290
100Pathways in cancer_Homo sapiens_hsa052000.48488342
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48107443
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.47983197
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47753533
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46669241
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46070121
106Legionellosis_Homo sapiens_hsa051340.44442806
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44147295
108Sulfur metabolism_Homo sapiens_hsa009200.44117902
109Nitrogen metabolism_Homo sapiens_hsa009100.43829799
110T cell receptor signaling pathway_Homo sapiens_hsa046600.43346767
111Colorectal cancer_Homo sapiens_hsa052100.42910719
112B cell receptor signaling pathway_Homo sapiens_hsa046620.42474347
113Lysine degradation_Homo sapiens_hsa003100.42204158
114Tryptophan metabolism_Homo sapiens_hsa003800.42072810
115Influenza A_Homo sapiens_hsa051640.40544759
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40340911
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40266221
118Leishmaniasis_Homo sapiens_hsa051400.39291681
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37944673
120Arachidonic acid metabolism_Homo sapiens_hsa005900.37898077
121Wnt signaling pathway_Homo sapiens_hsa043100.37833043
122N-Glycan biosynthesis_Homo sapiens_hsa005100.37195829
123Adherens junction_Homo sapiens_hsa045200.35946834
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.35628817
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.33411671
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32611362
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.31193583
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.31125098
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30895252
130Pentose phosphate pathway_Homo sapiens_hsa000300.30807152
131Hepatitis B_Homo sapiens_hsa051610.29972281
132Tight junction_Homo sapiens_hsa045300.28514035
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27979065
134Type I diabetes mellitus_Homo sapiens_hsa049400.27806574
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.26791410
136Ether lipid metabolism_Homo sapiens_hsa005650.26719430
137Sphingolipid metabolism_Homo sapiens_hsa006000.26401004
138Cardiac muscle contraction_Homo sapiens_hsa042600.26144422
139Arginine and proline metabolism_Homo sapiens_hsa003300.24841457
140Selenocompound metabolism_Homo sapiens_hsa004500.24772066
141Galactose metabolism_Homo sapiens_hsa000520.23447815
142Fructose and mannose metabolism_Homo sapiens_hsa000510.22638822
143Huntingtons disease_Homo sapiens_hsa050160.21078321
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20838829
145Circadian rhythm_Homo sapiens_hsa047100.20588313
146Linoleic acid metabolism_Homo sapiens_hsa005910.19850170
147Regulation of autophagy_Homo sapiens_hsa041400.19350338
148Toxoplasmosis_Homo sapiens_hsa051450.19174751
149Arginine biosynthesis_Homo sapiens_hsa002200.18571873
150Fatty acid biosynthesis_Homo sapiens_hsa000610.17736138

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