MKX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* collagen fibril organization (GO:0030199)6.10074237
2polyketide metabolic process (GO:0030638)5.92162167
3doxorubicin metabolic process (GO:0044598)5.92162167
4daunorubicin metabolic process (GO:0044597)5.92162167
5skin morphogenesis (GO:0043589)5.60533819
6protein heterotrimerization (GO:0070208)5.58715195
7type B pancreatic cell proliferation (GO:0044342)5.56040561
8endocardial cushion development (GO:0003197)5.47410314
9presynaptic membrane assembly (GO:0097105)5.43167307
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.05221446
11cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.98221901
12cell migration involved in heart development (GO:0060973)4.86378790
13neuron cell-cell adhesion (GO:0007158)4.80314044
14bone trabecula formation (GO:0060346)4.77073402
15postsynaptic membrane organization (GO:0001941)4.75723933
16presynaptic membrane organization (GO:0097090)4.74373319
17mesenchymal-epithelial cell signaling (GO:0060638)4.59416542
18chondrocyte proliferation (GO:0035988)4.42448269
19response to pheromone (GO:0019236)4.34702696
20vocalization behavior (GO:0071625)4.34692772
21startle response (GO:0001964)4.31762633
22regulation of glutamate receptor signaling pathway (GO:1900449)4.15298737
23extracellular matrix assembly (GO:0085029)4.13663921
24negative regulation of synaptic transmission, GABAergic (GO:0032229)4.10900497
25endothelial cell morphogenesis (GO:0001886)4.10333421
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.08835170
27positive regulation of fibroblast migration (GO:0010763)4.03962621
28locomotory exploration behavior (GO:0035641)4.02924971
29collagen metabolic process (GO:0032963)3.98531154
30chondrocyte development (GO:0002063)3.97896194
31neurotransmitter-gated ion channel clustering (GO:0072578)3.92529638
32protein localization to synapse (GO:0035418)3.91472127
33endodermal cell differentiation (GO:0035987)3.90943851
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.86087020
35negative regulation of axon extension involved in axon guidance (GO:0048843)3.83375026
36collagen catabolic process (GO:0030574)3.79304986
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.77599455
38negative regulation of smooth muscle cell migration (GO:0014912)3.71693830
39negative regulation of embryonic development (GO:0045992)3.70835065
40regulation of organ formation (GO:0003156)3.70326071
41auditory receptor cell stereocilium organization (GO:0060088)3.69627704
42multicellular organismal macromolecule metabolic process (GO:0044259)3.67899348
43planar cell polarity pathway involved in neural tube closure (GO:0090179)3.62810280
44glutamate secretion (GO:0014047)3.62225353
45adhesion of symbiont to host cell (GO:0044650)3.59929414
46virion attachment to host cell (GO:0019062)3.59929414
47cell migration involved in sprouting angiogenesis (GO:0002042)3.58828082
48positive regulation of synapse assembly (GO:0051965)3.55037148
49hypotonic response (GO:0006971)3.53471562
50righting reflex (GO:0060013)3.51875742
51anterior/posterior axis specification, embryo (GO:0008595)3.51848138
52positive regulation of endothelial cell apoptotic process (GO:2000353)3.51435602
53glomerular basement membrane development (GO:0032836)3.48244088
54regulation of short-term neuronal synaptic plasticity (GO:0048172)3.47859295
55regulation of synaptic vesicle exocytosis (GO:2000300)3.47191919
56multicellular organismal metabolic process (GO:0044236)3.47161642
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.45831471
58extracellular fibril organization (GO:0043206)3.45200057
59long term synaptic depression (GO:0060292)3.44806186
60positive regulation of macrophage activation (GO:0043032)3.44703890
61cell adhesion mediated by integrin (GO:0033627)3.44584840
62sequestering of extracellular ligand from receptor (GO:0035581)3.44474973
63synaptic transmission, glutamatergic (GO:0035249)3.43934445
64aminoglycoside antibiotic metabolic process (GO:0030647)3.43667447
65inner ear receptor stereocilium organization (GO:0060122)3.43227929
66negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.43079608
67multicellular organismal catabolic process (GO:0044243)3.41325223
68regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.40430827
69dermatan sulfate biosynthetic process (GO:0030208)3.38073367
70heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.37863699
71negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.36925611
72regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.36795313
73negative regulation of fatty acid transport (GO:2000192)3.35868521
74regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.35623271
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34675277
76neuron-neuron synaptic transmission (GO:0007270)3.32996127
77ionotropic glutamate receptor signaling pathway (GO:0035235)3.32758795
78outer ear morphogenesis (GO:0042473)3.32595261
79pericardium development (GO:0060039)3.32086744
80paraxial mesoderm development (GO:0048339)3.24853193
81glutamate receptor signaling pathway (GO:0007215)3.24342169
82extracellular negative regulation of signal transduction (GO:1900116)3.19678447
83extracellular regulation of signal transduction (GO:1900115)3.19678447
84positive regulation of synaptic transmission, GABAergic (GO:0032230)3.18019639
85middle ear morphogenesis (GO:0042474)3.17141082
86negative regulation of axon guidance (GO:1902668)3.16988532
87negative regulation of stem cell proliferation (GO:2000647)3.15621856
88embryonic cranial skeleton morphogenesis (GO:0048701)3.15474095
89positive regulation of blood vessel endothelial cell migration (GO:0043536)3.14770965
90negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14758972
91tooth mineralization (GO:0034505)3.14530559
92regulation of synaptic transmission, glutamatergic (GO:0051966)3.14384878
93exploration behavior (GO:0035640)3.12886721
94positive regulation of cartilage development (GO:0061036)3.11938395
95regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.10129116
96cellular response to vitamin (GO:0071295)3.09795929
97regulation of synapse assembly (GO:0051963)3.09489488
98fibril organization (GO:0097435)3.09079238
99synaptic vesicle exocytosis (GO:0016079)3.09075843
100protein retention in ER lumen (GO:0006621)3.07754093
101extracellular matrix disassembly (GO:0022617)3.04840812
102gamma-aminobutyric acid signaling pathway (GO:0007214)3.03199765
103adhesion of symbiont to host (GO:0044406)3.02865582
104blood vessel maturation (GO:0001955)3.01549969
105regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.00931984
106hyaluronan catabolic process (GO:0030214)3.00847507
107regulation of synaptic vesicle transport (GO:1902803)3.00038172
108negative regulation of BMP signaling pathway (GO:0030514)2.99884780
109smooth muscle tissue development (GO:0048745)2.99246122
110face morphogenesis (GO:0060325)2.98399514
111heparan sulfate proteoglycan metabolic process (GO:0030201)2.98140959
112COPI coating of Golgi vesicle (GO:0048205)2.97972604
113Golgi transport vesicle coating (GO:0048200)2.97972604
114long-term synaptic potentiation (GO:0060291)2.97442020
115regulation of plasminogen activation (GO:0010755)2.96442487
116positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.94990188
117muscle cell migration (GO:0014812)2.94678323
118cochlea morphogenesis (GO:0090103)2.93165560
119organ induction (GO:0001759)2.92244068
120regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.91534803
121lateral sprouting from an epithelium (GO:0060601)2.90973169
122maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.89616304
123regulation of synapse maturation (GO:0090128)2.89199337
124metanephric mesenchyme development (GO:0072075)2.88008145
125regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87833437
126regulation of axon extension involved in axon guidance (GO:0048841)2.87828832
127dermatan sulfate metabolic process (GO:0030205)2.87540867
128synaptic vesicle endocytosis (GO:0048488)2.87535852
129response to magnesium ion (GO:0032026)2.87501863
130serotonin receptor signaling pathway (GO:0007210)2.85716895
131cerebellar granule cell differentiation (GO:0021707)2.85229600
132substrate-dependent cell migration (GO:0006929)2.81360258
133negative regulation of synaptic transmission (GO:0050805)2.81246011
134negative regulation of chondrocyte differentiation (GO:0032331)2.81185624
135regulation of glutamate secretion (GO:0014048)2.80252092
136positive regulation of synapse maturation (GO:0090129)2.80065664
137urinary tract smooth muscle contraction (GO:0014848)2.80050748
138Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.77779733
139regulation of extracellular matrix disassembly (GO:0010715)2.76874148
140uterus development (GO:0060065)2.75748887
141establishment of planar polarity (GO:0001736)2.75458946
142establishment of tissue polarity (GO:0007164)2.75458946
143neuron projection extension involved in neuron projection guidance (GO:1902284)2.75021956
144axon extension involved in axon guidance (GO:0048846)2.75021956
145regulation of neurotransmitter secretion (GO:0046928)2.74764797
146membrane assembly (GO:0071709)2.74044819
147short-term memory (GO:0007614)2.73820448
148regulation of synaptic transmission, GABAergic (GO:0032228)2.73490968
149mammary gland epithelial cell proliferation (GO:0033598)2.73291246
150* extracellular matrix organization (GO:0030198)2.72423764
151* extracellular structure organization (GO:0043062)2.72167772
152positive regulation of mesenchymal cell proliferation (GO:0002053)2.71759754
153basement membrane organization (GO:0071711)2.71737066
154positive regulation of neurotransmitter secretion (GO:0001956)2.70641631
155cellular response to amino acid stimulus (GO:0071230)2.70048408
156positive regulation of catecholamine secretion (GO:0033605)2.69604100
157positive regulation of smoothened signaling pathway (GO:0045880)2.69230753
158negative regulation of neurotransmitter transport (GO:0051589)2.63584940
159chondroitin sulfate catabolic process (GO:0030207)2.61961208
160embryonic skeletal joint morphogenesis (GO:0060272)2.60686258
161kidney mesenchyme development (GO:0072074)2.58494676
162positive regulation of neurotransmitter transport (GO:0051590)2.56602665
163detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56166315
164regulation of excitatory postsynaptic membrane potential (GO:0060079)2.56106118
165neuron recognition (GO:0008038)2.54945560
166detection of mechanical stimulus involved in sensory perception (GO:0050974)2.54929207
167regulation of neurotransmitter transport (GO:0051588)2.54915750
168forelimb morphogenesis (GO:0035136)2.54557193
169regulation of synapse organization (GO:0050807)2.52846341
170regulation of respiratory system process (GO:0044065)2.52269593
171reflex (GO:0060004)2.52088767
172innervation (GO:0060384)2.51453569
173cerebral cortex radially oriented cell migration (GO:0021799)2.50929803
174synaptic vesicle maturation (GO:0016188)2.50754976
175embryonic forelimb morphogenesis (GO:0035115)2.50405830
176opioid receptor signaling pathway (GO:0038003)2.48427983
177regulation of axon guidance (GO:1902667)2.44936885
178regulation of postsynaptic membrane potential (GO:0060078)2.44893516
179regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.44347325
180regulation of synaptic plasticity (GO:0048167)2.44338177
181neurotransmitter secretion (GO:0007269)2.43718370
182regulation of amino acid transport (GO:0051955)2.42216615
183regulation of long-term neuronal synaptic plasticity (GO:0048169)2.41525873
184negative regulation of dendrite morphogenesis (GO:0050774)2.40880585
185regulation of vesicle fusion (GO:0031338)2.40068466
186regulation of receptor internalization (GO:0002090)2.40018731
187transferrin transport (GO:0033572)2.38496948
188central nervous system projection neuron axonogenesis (GO:0021952)2.37612200
189transmission of nerve impulse (GO:0019226)2.37129980
190positive regulation of membrane potential (GO:0045838)2.36826385
191detection of calcium ion (GO:0005513)2.36509724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.58475213
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.36182717
3EZH2_22144423_ChIP-Seq_EOC_Human4.05366593
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.73889012
5* BRD4_25478319_ChIP-Seq_HGPS_Human3.19373542
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81444418
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.80596071
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74110158
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72305523
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67689642
11RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.63084195
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59888169
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58161799
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58161799
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52119436
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.51326975
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47824332
18* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.47138959
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.41799150
20TAF15_26573619_Chip-Seq_HEK293_Human2.40655670
21CJUN_26792858_Chip-Seq_BT549_Human2.38842943
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.36755426
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32216281
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30706339
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24609434
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.21205578
27TP63_17297297_ChIP-ChIP_HaCaT_Human2.14112610
28* RNF2_27304074_Chip-Seq_ESCs_Mouse2.09384583
29EP300_21415370_ChIP-Seq_HL-1_Mouse2.05463827
30PIAS1_25552417_ChIP-Seq_VCAP_Human2.01536835
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.99195261
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95368782
33* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94055788
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.93759551
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93071150
36CLOCK_20551151_ChIP-Seq_293T_Human1.91274824
37TP53_16413492_ChIP-PET_HCT116_Human1.90328380
38* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87973662
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.87815937
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87507415
41* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85503758
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82680369
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.81473746
44P300_19829295_ChIP-Seq_ESCs_Human1.80875108
45AR_21909140_ChIP-Seq_LNCAP_Human1.80812988
46* EZH2_27294783_Chip-Seq_ESCs_Mouse1.79111364
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.76450143
48* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75670283
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74739680
50* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71875151
51FUS_26573619_Chip-Seq_HEK293_Human1.70093447
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67426997
53DROSHA_22980978_ChIP-Seq_HELA_Human1.65959857
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.64352447
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63791822
56AR_21572438_ChIP-Seq_LNCaP_Human1.63750971
57VDR_22108803_ChIP-Seq_LS180_Human1.62340265
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.60549582
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57789355
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55015514
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53453873
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53088587
63AR_25329375_ChIP-Seq_VCAP_Human1.50307992
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49158653
65REST_21632747_ChIP-Seq_MESCs_Mouse1.48946802
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48060161
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45739072
68TP53_18474530_ChIP-ChIP_U2OS_Human1.43685445
69SMC1_22415368_ChIP-Seq_MEFs_Mouse1.43432768
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.43361990
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.43361990
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42974910
73TP53_22127205_ChIP-Seq_IMR90_Human1.42642147
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42338896
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42076167
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41701482
77* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40876285
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40113977
79TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.37712646
80RNF2_27304074_Chip-Seq_NSC_Mouse1.36881656
81TRIM28_21343339_ChIP-Seq_HEK293_Human1.35514227
82JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35270106
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35262121
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35249439
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34603894
86* SA1_22415368_ChIP-Seq_MEFs_Mouse1.33518577
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32793035
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32477549
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32441743
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31258605
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31215579
92STAT3_23295773_ChIP-Seq_U87_Human1.30235584
93TP53_23651856_ChIP-Seq_MEFs_Mouse1.29650394
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.27658493
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27629016
96UBF1/2_26484160_Chip-Seq_HMECs_Human1.27516668
97NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26863743
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.26672870
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26589126
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26145604
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25778033
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25556601
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24193261
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23246551
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23224097
106TCF4_23295773_ChIP-Seq_U87_Human1.22779251
107* ARNT_22903824_ChIP-Seq_MCF-7_Human1.21944228
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21155587
109FLI1_27457419_Chip-Seq_LIVER_Mouse1.20971185
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20790959
111ER_23166858_ChIP-Seq_MCF-7_Human1.20380444
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20295972
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.19400675
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19399871
115* RUNX2_22187159_ChIP-Seq_PCA_Human1.18615691
116ELK3_25401928_ChIP-Seq_HUVEC_Human1.17961391
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17793183
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17718203
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15566484
120ZNF274_21170338_ChIP-Seq_K562_Hela1.15406568
121HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15055587
122CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14665303
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.14281666
124ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12956413
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12597871
126JUN_21703547_ChIP-Seq_K562_Human1.12356959
127P53_22387025_ChIP-Seq_ESCs_Mouse1.12083024
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11372355
129NFE2_27457419_Chip-Seq_LIVER_Mouse1.11305185
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10867939
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10867939
132* RING1B_27294783_Chip-Seq_ESCs_Mouse1.10841163
133SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10311170
134MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10301305
135* TP53_20018659_ChIP-ChIP_R1E_Mouse1.09657680
136ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08894687
137CMYC_18555785_Chip-Seq_ESCs_Mouse1.08881053
138THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08795308
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08685910
140BCAT_22108803_ChIP-Seq_LS180_Human1.08483867
141NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08307417
142WT1_19549856_ChIP-ChIP_CCG9911_Human1.08203324
143NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08148677
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05923831
145NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05923831
146VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05752026
147P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05056265
148AR_19668381_ChIP-Seq_PC3_Human1.04748663
149SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04340669
150* AHR_22903824_ChIP-Seq_MCF-7_Human1.04199322
151ATF3_27146783_Chip-Seq_COLON_Human1.03204962
152YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02788740
153STAT3_18555785_Chip-Seq_ESCs_Mouse1.01073016
154ISL1_27105846_Chip-Seq_CPCs_Mouse0.97719620
155PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96937218
156ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96030029
157EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95368827
158TET1_21490601_ChIP-Seq_MESCs_Mouse0.95245029
159* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93055230
160FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92393985
161POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91692683
162NFI_21473784_ChIP-Seq_ESCs_Mouse0.88364011
163ESR1_21235772_ChIP-Seq_MCF-7_Human0.88009484
164TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87999987
165PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.87717837
166PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.87464196
167TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87365031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.57131450
2MP0003880_abnormal_central_pattern4.18260829
3MP0001958_emphysema3.85226094
4MP0004859_abnormal_synaptic_plasticity3.79235281
5MP0003279_aneurysm3.65025894
6MP0003941_abnormal_skin_development3.63611444
7MP0001542_abnormal_bone_strength3.09359592
8* MP0005503_abnormal_tendon_morphology2.93784507
9MP0005646_abnormal_pituitary_gland2.89073956
10MP0006054_spinal_hemorrhage2.86034261
11MP0005171_absent_coat_pigmentation2.71226616
12MP0001348_abnormal_lacrimal_gland2.55276636
13MP0003635_abnormal_synaptic_transmissio2.47618764
14MP0009745_abnormal_behavioral_response2.36893596
15MP0001968_abnormal_touch/_nociception2.32272843
16MP0008438_abnormal_cutaneous_collagen2.25574872
17MP0000566_synostosis2.21854880
18MP0003787_abnormal_imprinting2.15853235
19MP0009046_muscle_twitch2.12418901
20MP0002064_seizures2.05103905
21MP0002736_abnormal_nociception_after2.04863139
22MP0005023_abnormal_wound_healing2.03580553
23MP0002735_abnormal_chemical_nociception2.01568695
24MP0010352_gastrointestinal_tract_polyps2.00964727
25MP0002063_abnormal_learning/memory/cond1.97418917
26MP0001486_abnormal_startle_reflex1.94004004
27MP0002572_abnormal_emotion/affect_behav1.93854752
28MP0009697_abnormal_copulation1.87864259
29MP0001188_hyperpigmentation1.84288351
30MP0008004_abnormal_stomach_pH1.83514396
31MP0002060_abnormal_skin_morphology1.82413216
32MP0001243_abnormal_dermal_layer1.78507184
33MP0002272_abnormal_nervous_system1.76239842
34MP0000751_myopathy1.74189341
35MP0002295_abnormal_pulmonary_circulatio1.72787530
36MP0003091_abnormal_cell_migration1.72315537
37MP0001299_abnormal_eye_distance/1.64399855
38MP0002896_abnormal_bone_mineralization1.62457161
39MP0002557_abnormal_social/conspecific_i1.62212807
40MP0005423_abnormal_somatic_nervous1.58918229
41MP0001984_abnormal_olfaction1.56493982
42MP0000767_abnormal_smooth_muscle1.56063031
43MP0003385_abnormal_body_wall1.55109783
44MP0006292_abnormal_olfactory_placode1.54803730
45MP0002184_abnormal_innervation1.53865954
46MP0003566_abnormal_cell_adhesion1.52572559
47MP0000537_abnormal_urethra_morphology1.50756109
48MP0002877_abnormal_melanocyte_morpholog1.50720464
49MP0002067_abnormal_sensory_capabilities1.50418332
50MP0000013_abnormal_adipose_tissue1.50069732
51MP0010386_abnormal_urinary_bladder1.48758127
52MP0002734_abnormal_mechanical_nocicepti1.47786593
53MP0009250_abnormal_appendicular_skeleto1.47172463
54MP0002249_abnormal_larynx_morphology1.46696617
55MP0003122_maternal_imprinting1.45672101
56MP0009780_abnormal_chondrocyte_physiolo1.41535128
57MP0003937_abnormal_limbs/digits/tail_de1.41228977
58MP0003283_abnormal_digestive_organ1.40271876
59MP0006276_abnormal_autonomic_nervous1.38947329
60MP0003938_abnormal_ear_development1.38127764
61MP0002876_abnormal_thyroid_physiology1.38040933
62MP0003942_abnormal_urinary_system1.35971947
63MP0001177_atelectasis1.35339944
64MP0000778_abnormal_nervous_system1.35327192
65MP0004270_analgesia1.34284133
66MP0000049_abnormal_middle_ear1.32581139
67MP0001501_abnormal_sleep_pattern1.28300589
68MP0003879_abnormal_hair_cell1.23901067
69MP0003950_abnormal_plasma_membrane1.22794867
70MP0010030_abnormal_orbit_morphology1.21712468
71MP0002233_abnormal_nose_morphology1.20181165
72* MP0002108_abnormal_muscle_morphology1.19664816
73MP0005623_abnormal_meninges_morphology1.18178461
74MP0001346_abnormal_lacrimal_gland1.17827092
75MP0009384_cardiac_valve_regurgitation1.17779485
76MP0001440_abnormal_grooming_behavior1.16799451
77MP0004742_abnormal_vestibular_system1.16381192
78MP0001970_abnormal_pain_threshold1.14481366
79MP0010368_abnormal_lymphatic_system1.13969619
80MP0009053_abnormal_anal_canal1.13155551
81MP0005275_abnormal_skin_tensile1.12121850
82MP0000762_abnormal_tongue_morphology1.10043393
83* MP0005508_abnormal_skeleton_morphology1.08629631
84MP0000733_abnormal_muscle_development1.07204207
85MP0002277_abnormal_respiratory_mucosa1.05355333
86MP0004924_abnormal_behavior1.04502139
87MP0005386_behavior/neurological_phenoty1.04502139
88MP0000955_abnormal_spinal_cord1.03215540
89MP0001502_abnormal_circadian_rhythm1.03045450
90MP0004858_abnormal_nervous_system1.02288948
91* MP0005390_skeleton_phenotype1.02129221
92MP0000678_abnormal_parathyroid_gland1.02113734
93MP0002282_abnormal_trachea_morphology1.01355836
94MP0001963_abnormal_hearing_physiology1.00917026
95MP0005595_abnormal_vascular_smooth1.00418142
96MP0000026_abnormal_inner_ear0.99720086
97MP0005367_renal/urinary_system_phenotyp0.99409123
98MP0000516_abnormal_urinary_system0.99409123
99MP0004233_abnormal_muscle_weight0.99365703
100MP0005084_abnormal_gallbladder_morpholo0.97952237
101MP0003755_abnormal_palate_morphology0.97210499
102MP0002932_abnormal_joint_morphology0.96073274
103MP0000432_abnormal_head_morphology0.93734419
104MP0000534_abnormal_ureter_morphology0.93392793
105MP0002733_abnormal_thermal_nociception0.92115308
106MP0004885_abnormal_endolymph0.91471940
107MP0000759_abnormal_skeletal_muscle0.90670287
108MP0000631_abnormal_neuroendocrine_gland0.89678202
109MP0002882_abnormal_neuron_morphology0.89441584
110MP0005645_abnormal_hypothalamus_physiol0.89268900
111MP0003878_abnormal_ear_physiology0.89141787
112MP0005377_hearing/vestibular/ear_phenot0.89141787
113MP0001905_abnormal_dopamine_level0.88698960
114MP0002115_abnormal_skeleton_extremities0.86238425
115MP0003115_abnormal_respiratory_system0.85868714
116MP0002160_abnormal_reproductive_system0.85771821
117MP0000428_abnormal_craniofacial_morphol0.85552487
118MP0003121_genomic_imprinting0.85029294
119MP0004134_abnormal_chest_morphology0.84626715
120MP0002116_abnormal_craniofacial_bone0.84559728
121MP0005551_abnormal_eye_electrophysiolog0.84421311
122MP0004811_abnormal_neuron_physiology0.84413687
123MP0002109_abnormal_limb_morphology0.84369189
124MP0001664_abnormal_digestion0.83557810
125MP0004272_abnormal_basement_membrane0.83072797
126MP0002114_abnormal_axial_skeleton0.82975537
127MP0005257_abnormal_intraocular_pressure0.82091394
128MP0005197_abnormal_uvea_morphology0.81974901
129MP0000163_abnormal_cartilage_morphology0.81080699
130MP0002066_abnormal_motor_capabilities/c0.80428621
131MP0002113_abnormal_skeleton_development0.80403762
132MP0002751_abnormal_autonomic_nervous0.78791688
133MP0001529_abnormal_vocalization0.77572018
134MP0005164_abnormal_response_to0.75036304
135MP0005076_abnormal_cell_differentiation0.71720433
136MP0000003_abnormal_adipose_tissue0.71091643
137MP0000749_muscle_degeneration0.68082351
138MP0000538_abnormal_urinary_bladder0.63675390
139MP0002128_abnormal_blood_circulation0.62802439
140MP0005193_abnormal_anterior_eye0.62515244
141MP0003795_abnormal_bone_structure0.61364003
142MP0005187_abnormal_penis_morphology0.60870350
143MP0003935_abnormal_craniofacial_develop0.60777731
144MP0000750_abnormal_muscle_regeneration0.60576877
145MP0001270_distended_abdomen0.60176931
146MP0000462_abnormal_digestive_system0.59376883
147MP0003448_altered_tumor_morphology0.59346430
148MP0001175_abnormal_lung_morphology0.58804659
149MP0005388_respiratory_system_phenotype0.58701665
150MP0002133_abnormal_respiratory_system0.58701665
151MP0002697_abnormal_eye_size0.57706384
152MP0002111_abnormal_tail_morphology0.56684257
153MP0001849_ear_inflammation0.55658612
154MP0003045_fibrosis0.54468654
155MP0001340_abnormal_eyelid_morphology0.53927973
156MP0001614_abnormal_blood_vessel0.53405655
157MP0002177_abnormal_outer_ear0.52703930
158MP0001661_extended_life_span0.51115951
159MP0002092_abnormal_eye_morphology0.50258193
160MP0002168_other_aberrant_phenotype0.49214733
161MP0000467_abnormal_esophagus_morphology0.48580693
162MP0002925_abnormal_cardiovascular_devel0.46738719
163MP0005621_abnormal_cell_physiology0.45466336
164MP0001881_abnormal_mammary_gland0.44219840
165MP0001286_abnormal_eye_development0.43717203
166MP0004087_abnormal_muscle_fiber0.42112105

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.19205314
2Focal motor seizures (HP:0011153)5.29719917
3Aortic dissection (HP:0002647)4.94889708
4Aortic aneurysm (HP:0004942)4.93209218
5Febrile seizures (HP:0002373)4.69147871
6Soft skin (HP:0000977)4.67054863
7Ankle contracture (HP:0006466)4.57254681
8Morphological abnormality of the middle ear (HP:0008609)4.23740951
9Bladder diverticulum (HP:0000015)4.20191505
10Atrophic scars (HP:0001075)4.10245593
11Epileptic encephalopathy (HP:0200134)3.95414837
12Vascular tortuosity (HP:0004948)3.90358703
13Fragile skin (HP:0001030)3.88265527
14Wormian bones (HP:0002645)3.64529653
15Genu recurvatum (HP:0002816)3.62639043
16Peritonitis (HP:0002586)3.62341894
17Atonic seizures (HP:0010819)3.57984750
18Broad metatarsal (HP:0001783)3.52759777
19Bowel diverticulosis (HP:0005222)3.51051353
20Type 1 muscle fiber predominance (HP:0003803)3.46003037
21Cutaneous finger syndactyly (HP:0010554)3.35645927
22Dilatation of the ascending aorta (HP:0005111)3.27408129
23Spinal rigidity (HP:0003306)3.27026884
24Abnormality of the nasal septum (HP:0000419)3.18429959
25Ulnar bowing (HP:0003031)3.13973947
26Absent eyebrow (HP:0002223)3.13326989
27Focal seizures (HP:0007359)3.13317423
28Hyperventilation (HP:0002883)3.13199940
29Vertebral compression fractures (HP:0002953)3.12869966
30Blue sclerae (HP:0000592)3.09167142
31Wide anterior fontanel (HP:0000260)3.03005201
32Synostosis involving the elbow (HP:0003938)3.02956593
33Humeroradial synostosis (HP:0003041)3.02956593
34Follicular hyperkeratosis (HP:0007502)3.02170153
35Mitral regurgitation (HP:0001653)3.00210390
36Arterial tortuosity (HP:0005116)2.99609407
37Sparse lateral eyebrow (HP:0005338)2.98384670
38Mild short stature (HP:0003502)2.95834569
39Cutaneous syndactyly (HP:0012725)2.87673740
40Overgrowth (HP:0001548)2.81036525
41Mitral valve prolapse (HP:0001634)2.79621487
42Slender build (HP:0001533)2.77946530
43Abnormal delivery (HP:0001787)2.77509891
44Premature rupture of membranes (HP:0001788)2.76301410
45Hyperextensible skin (HP:0000974)2.68839506
46Spondylolisthesis (HP:0003302)2.66297080
47Elbow flexion contracture (HP:0002987)2.65470723
48Absent frontal sinuses (HP:0002688)2.64433908
49Absent eyelashes (HP:0000561)2.63069420
50Joint laxity (HP:0001388)2.62138742
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.61131902
52Osteolytic defects of the hand bones (HP:0009699)2.61131902
53Cervical subluxation (HP:0003308)2.57999856
54Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.56992680
55Abnormality of the middle phalanges of the toes (HP:0010183)2.54750634
56Progressive cerebellar ataxia (HP:0002073)2.54458508
57Myokymia (HP:0002411)2.53060956
58Congenital sensorineural hearing impairment (HP:0008527)2.48346658
59Abnormality of incisor morphology (HP:0011063)2.45665877
60Abnormality of the acetabulum (HP:0003170)2.43022969
61Short clavicles (HP:0000894)2.42219361
62Fibular aplasia (HP:0002990)2.37168272
63Deviation of the hallux (HP:0010051)2.34732982
64Generalized tonic-clonic seizures (HP:0002069)2.31115816
65Abnormality of dentin (HP:0010299)2.30259086
66Aplasia/Hypoplasia of the clavicles (HP:0006710)2.29809752
67Osteomalacia (HP:0002749)2.28078504
68Mitral stenosis (HP:0001718)2.26466654
69Nonimmune hydrops fetalis (HP:0001790)2.24661700
70Symphalangism affecting the phalanges of the hand (HP:0009773)2.23276343
71Syringomyelia (HP:0003396)2.22217824
72Spinal cord lesions (HP:0100561)2.22217824
73Narrow nasal bridge (HP:0000446)2.20352030
74Short hallux (HP:0010109)2.20051088
75Short nail (HP:0001799)2.19670112
76Submucous cleft hard palate (HP:0000176)2.19549517
77Breech presentation (HP:0001623)2.19426347
78Renal duplication (HP:0000075)2.18223034
79J-shaped sella turcica (HP:0002680)2.17938279
80Recurrent corneal erosions (HP:0000495)2.17787098
81Spinal canal stenosis (HP:0003416)2.16737747
82Flared iliac wings (HP:0002869)2.16427532
83Aortic valve stenosis (HP:0001650)2.15044847
84Protruding tongue (HP:0010808)2.14895112
85Mildly elevated creatine phosphokinase (HP:0008180)2.14139214
86Obstructive sleep apnea (HP:0002870)2.13684726
87Abnormality of the proximal phalanges of the hand (HP:0009834)2.09873033
88Increased variability in muscle fiber diameter (HP:0003557)2.09664024
89Chronic hepatic failure (HP:0100626)2.09421698
90Hallux valgus (HP:0001822)2.09193343
91Dialeptic seizures (HP:0011146)2.08616583
92Absence seizures (HP:0002121)2.06265342
93Hypothermia (HP:0002045)2.06143409
94Broad ribs (HP:0000885)2.05995730
95Infantile muscular hypotonia (HP:0008947)2.04993642
96Absent speech (HP:0001344)2.04874758
97Redundant skin (HP:0001582)2.04536414
98Optic nerve hypoplasia (HP:0000609)2.04240430
99Aplasia/Hypoplasia of the hallux (HP:0008362)2.04197448
100Aneurysm (HP:0002617)2.03709462
101Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.03574469
102Coronal craniosynostosis (HP:0004440)2.03106638
103Abnormality of the ischium (HP:0003174)2.01915962
104Aplasia cutis congenita (HP:0001057)2.01253956
105Blue irides (HP:0000635)2.01127798
106Abnormality of the nasolacrimal system (HP:0000614)1.99270190
107Calcaneovalgus deformity (HP:0001848)1.97699594
108Sleep apnea (HP:0010535)1.97382469
109Ectopia lentis (HP:0001083)1.97237468
110Bowed forearm bones (HP:0003956)1.96626631
111Bowing of the arm (HP:0006488)1.96626631
112Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.95808326
113Natal tooth (HP:0000695)1.95581032
114Radial bowing (HP:0002986)1.95258570
115Aplasia/Hypoplasia of the tibia (HP:0005772)1.95156504
116Short middle phalanx of the 5th finger (HP:0004220)1.94841013
117Abnormality of the frontal sinuses (HP:0002687)1.94639294
118Septo-optic dysplasia (HP:0100842)1.94133174
119Delayed closure of the anterior fontanelle (HP:0001476)1.93701403
120Broad long bones (HP:0005622)1.93276207
121Long nose (HP:0003189)1.93192695
122Delayed cranial suture closure (HP:0000270)1.93099611
123Flat cornea (HP:0007720)1.90062568
124Alopecia of scalp (HP:0002293)1.90029585
125Neonatal short-limb short stature (HP:0008921)1.89995654
126Abnormality of skull ossification (HP:0002703)1.89973592
127Hypoventilation (HP:0002791)1.89627796
128Abnormality of carpal bone ossification (HP:0006257)1.88923321
129Tibial bowing (HP:0002982)1.88182487
130Abnormal ossification of hand bones (HP:0005921)1.86953474
131Abnormality of the phalanges of the hallux (HP:0010057)1.86340461
132Biconcave vertebral bodies (HP:0004586)1.86019879
133Aplasia/Hypoplasia of the sternum (HP:0006714)1.85826703
134Inguinal hernia (HP:0000023)1.85616730
135Short tibia (HP:0005736)1.84770314
136Aplasia involving bones of the upper limbs (HP:0009823)1.84568802
137Aplasia of the phalanges of the hand (HP:0009802)1.84568802
138Aplasia involving bones of the extremities (HP:0009825)1.84568802
139Deformed tarsal bones (HP:0008119)1.84166322
140Decreased skull ossification (HP:0004331)1.81818940
141Spinal cord compression (HP:0002176)1.81370292
142Osteoarthritis (HP:0002758)1.81233956
143Adrenal hypoplasia (HP:0000835)1.81224935
144Protruding ear (HP:0000411)1.81135247
145Abnormality of the phalanges of the 5th finger (HP:0004213)1.80355041
146Insomnia (HP:0100785)1.80297074
147Camptodactyly of toe (HP:0001836)1.80293260
148Abnormality of the lacrimal duct (HP:0011481)1.79890717
149Short 5th finger (HP:0009237)1.79807084
150Aortic regurgitation (HP:0001659)1.79573807
151Abnormal hair whorl (HP:0010721)1.79425274
152Genital tract atresia (HP:0001827)1.76829128
153Round ear (HP:0100830)1.76549530
154Knee flexion contracture (HP:0006380)1.75937609
155Synostosis involving bones of the lower limbs (HP:0009138)1.75799507
156Synostosis involving bones of the feet (HP:0009140)1.75799507
157Myelomeningocele (HP:0002475)1.74685350
158True hermaphroditism (HP:0010459)1.74680532
159Increased connective tissue (HP:0009025)1.74565346
160Vaginal atresia (HP:0000148)1.73619961
161Hyperacusis (HP:0010780)1.73399792
162Aplasia/Hypoplasia of the lens (HP:0008063)1.72810612
163Bell-shaped thorax (HP:0001591)1.72433508
164Short foot (HP:0001773)1.72144704
165Gaze-evoked nystagmus (HP:0000640)1.72017680
166Abnormality of skeletal muscle fiber size (HP:0012084)1.71058211
167Shallow orbits (HP:0000586)1.70670375
168Abnormal finger flexion creases (HP:0006143)1.70608683
169Corneal dystrophy (HP:0001131)1.70424490
170Gait imbalance (HP:0002141)1.69420233
171Aqueductal stenosis (HP:0002410)1.68176888
172Absent phalangeal crease (HP:0006109)1.66409771
173Conical tooth (HP:0000698)1.66372162
174Parakeratosis (HP:0001036)1.66359982
175Absent hair (HP:0002298)1.65769029
176Mesomelia (HP:0003027)1.64520694
177Tracheomalacia (HP:0002779)1.63860233
178Tarsal synostosis (HP:0008368)1.63619389
179Midline defect of the nose (HP:0004122)1.62474142
180Congenital primary aphakia (HP:0007707)1.62015669
181Wrist flexion contracture (HP:0001239)1.61701101
182Renal dysplasia (HP:0000110)1.59648611
183Omphalocele (HP:0001539)1.59572969
184Synostosis of carpal bones (HP:0005048)1.59566210
185Anophthalmia (HP:0000528)1.59269213
186Medial flaring of the eyebrow (HP:0010747)1.58999557
187Methylmalonic acidemia (HP:0002912)1.57477212

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.09416424
2NTRK34.30988823
3NEK94.25050352
4PRPF4B3.64929577
5MAP2K73.48555638
6EPHA43.37403310
7TTN3.13144439
8SIK32.99164925
9PAK22.64990144
10MAP3K42.53776727
11AKT32.46429570
12MST1R2.36697349
13PLK22.18391733
14ZAK2.02437223
15PTK21.97700562
16PRKD21.85336989
17SGK21.84419636
18LIMK11.77870801
19TNIK1.76417329
20MAP3K121.76344797
21MET1.75317403
22PNCK1.75166045
23TESK11.62204190
24RIPK11.61308061
25SGK4941.58099651
26SGK2231.58099651
27INSRR1.53584694
28LATS11.51748108
29LATS21.49786024
30CDK121.48915312
31PDGFRB1.45524192
32ERBB31.45375548
33MAP2K41.32031038
34PIK3CG1.29935125
35FER1.29670066
36MAPK131.25270694
37EPHA21.23343928
38BMPR21.21146881
39DAPK21.20725071
40DDR21.19931363
41NTRK21.18573252
42ADRBK21.17110706
43TAOK21.16248492
44MINK11.14213743
45ABL21.14209043
46MAPK151.13559680
47PRKCG1.11680794
48SIK11.11580468
49GRK51.10745330
50MARK11.09942107
51SIK21.09450376
52TRIB31.07496429
53SGK31.07336646
54SCYL21.06058871
55BCR1.03271757
56MTOR1.01324364
57TNK20.98696337
58CAMK2A0.95202179
59FRK0.94839676
60STK38L0.94098947
61PRKCE0.93338516
62YES10.92805305
63PAK40.91543685
64CAMK10.87500430
65STK30.87316244
66CDK80.87060357
67PHKG10.84414208
68PHKG20.84414208
69CDK30.83504742
70RPS6KA20.83381488
71BRSK20.79101537
72KIT0.77812882
73NEK60.76971213
74TGFBR20.75811657
75DYRK1A0.75489895
76ERN10.75407712
77TRPM70.75377128
78PAK60.75201764
79PDGFRA0.73660081
80EEF2K0.73157239
81MAPK70.71439755
82PINK10.71150050
83MKNK20.70872025
84CDK70.70064860
85PBK0.69927276
86ICK0.68230846
87PIM20.67994015
88CDK50.65370640
89CCNB10.63757700
90SGK10.63690590
91GSK3A0.62694838
92PLK30.62655079
93BRSK10.62301705
94ROCK20.62174313
95MELK0.60325965
96PRKCH0.59107725
97CDC42BPA0.57924872
98STK380.57561131
99WEE10.55508149
100CAMK40.55022880
101MKNK10.54745022
102MAP3K60.54212364
103OXSR10.52718945
104PKN10.52078907
105BMX0.51800378
106WNK40.51296798
107JAK10.50647914
108PRKG20.50603074
109MARK20.50526676
110CAMK2D0.49914508
111DMPK0.49650297
112MOS0.49606296
113PRKG10.48973620
114MYLK0.48644534
115PTK2B0.48459271
116FGFR10.47736601
117BMPR1B0.47501134
118EIF2AK20.46331739
119DAPK30.46010837
120SMG10.45468694
121MAP2K10.45408986
122PAK30.45129963
123CAMK1G0.45054151
124BRD40.44979152
125CDK190.44676660
126RPS6KC10.44596010
127RPS6KL10.44596010
128NME10.44063161
129WNK10.43993639
130ADRBK10.43782952
131MAP3K140.43422006
132STK390.43166317
133DAPK10.42861911
134CAMK2B0.41263724
135MAPKAPK50.40227769
136MUSK0.39626717
137PRKD30.39591589
138CHEK20.39280808
139NTRK10.38025371
140EPHB20.37266140
141FLT30.37134534
142NEK20.36171456
143PRKD10.35097473
144ERBB40.35076669
145TSSK60.33683632
146PRKCZ0.33678549
147RPS6KB10.33612019
148PRKCA0.32693665
149RIPK40.32641619
150RPS6KA60.32558314
151PRKACA0.31945168
152CDK60.31822149
153DYRK1B0.31462788
154ILK0.31261295
155CSNK1A10.31008034
156FGFR20.30953234
157PAK10.30837617
158CAMK2G0.29875973
159GRK70.29359292
160MST40.29192046
161ROCK10.29100141
162PRKACB0.28445988
163TTK0.26713284
164CDK90.25998104

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.24504553
2Synaptic vesicle cycle_Homo sapiens_hsa047213.54658188
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90779162
4Collecting duct acid secretion_Homo sapiens_hsa049662.73943838
5Circadian entrainment_Homo sapiens_hsa047132.46889569
6GABAergic synapse_Homo sapiens_hsa047272.38151458
7Morphine addiction_Homo sapiens_hsa050322.35279833
8Taste transduction_Homo sapiens_hsa047422.31107980
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.28600041
10Proteoglycans in cancer_Homo sapiens_hsa052052.25834136
11Glutamatergic synapse_Homo sapiens_hsa047242.18404277
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.15374184
13Olfactory transduction_Homo sapiens_hsa047402.05647656
14Amphetamine addiction_Homo sapiens_hsa050311.89372160
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88918860
16Serotonergic synapse_Homo sapiens_hsa047261.86974920
17Vibrio cholerae infection_Homo sapiens_hsa051101.82098747
18Bladder cancer_Homo sapiens_hsa052191.78011348
19Dopaminergic synapse_Homo sapiens_hsa047281.70602539
20Calcium signaling pathway_Homo sapiens_hsa040201.61084226
21Cholinergic synapse_Homo sapiens_hsa047251.56497609
22Insulin secretion_Homo sapiens_hsa049111.56416588
23Amoebiasis_Homo sapiens_hsa051461.54661814
24Salivary secretion_Homo sapiens_hsa049701.53575607
25Axon guidance_Homo sapiens_hsa043601.50184722
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.48738251
27Rheumatoid arthritis_Homo sapiens_hsa053231.47956713
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47538661
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.44447525
30MicroRNAs in cancer_Homo sapiens_hsa052061.43892586
31Small cell lung cancer_Homo sapiens_hsa052221.42091469
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37696056
33Long-term depression_Homo sapiens_hsa047301.36166864
34Long-term potentiation_Homo sapiens_hsa047201.31426338
35Pancreatic secretion_Homo sapiens_hsa049721.26898447
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25492206
37Oxytocin signaling pathway_Homo sapiens_hsa049211.24520466
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23767844
39Dilated cardiomyopathy_Homo sapiens_hsa054141.23500748
40Chronic myeloid leukemia_Homo sapiens_hsa052201.21320207
41Pathways in cancer_Homo sapiens_hsa052001.18815701
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16664482
43p53 signaling pathway_Homo sapiens_hsa041151.16404635
44Prostate cancer_Homo sapiens_hsa052151.15793596
45Renin secretion_Homo sapiens_hsa049241.14327278
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12175922
47Melanoma_Homo sapiens_hsa052181.12139451
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12115354
49Vitamin B6 metabolism_Homo sapiens_hsa007501.11378162
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10407418
51Cocaine addiction_Homo sapiens_hsa050301.10316179
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08074734
53Ovarian steroidogenesis_Homo sapiens_hsa049131.07507974
54Central carbon metabolism in cancer_Homo sapiens_hsa052301.06978743
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05873563
56Protein digestion and absorption_Homo sapiens_hsa049741.04117849
57Malaria_Homo sapiens_hsa051441.00863891
58GnRH signaling pathway_Homo sapiens_hsa049120.97455722
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93209810
60Type II diabetes mellitus_Homo sapiens_hsa049300.92464629
61ErbB signaling pathway_Homo sapiens_hsa040120.90992611
62Selenocompound metabolism_Homo sapiens_hsa004500.90107103
63Wnt signaling pathway_Homo sapiens_hsa043100.88493293
64Prion diseases_Homo sapiens_hsa050200.88395344
65cAMP signaling pathway_Homo sapiens_hsa040240.88204793
66Hedgehog signaling pathway_Homo sapiens_hsa043400.88055197
67Gastric acid secretion_Homo sapiens_hsa049710.85654819
68Cardiac muscle contraction_Homo sapiens_hsa042600.85170394
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84906766
70One carbon pool by folate_Homo sapiens_hsa006700.84692886
71Melanogenesis_Homo sapiens_hsa049160.82541121
72Thyroid cancer_Homo sapiens_hsa052160.81750455
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.81545286
74Gap junction_Homo sapiens_hsa045400.81025261
75Pancreatic cancer_Homo sapiens_hsa052120.80932596
76Phagosome_Homo sapiens_hsa041450.79939557
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79883652
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79807471
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74680214
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74193470
81Glioma_Homo sapiens_hsa052140.74113208
82Oxidative phosphorylation_Homo sapiens_hsa001900.73726131
83MAPK signaling pathway_Homo sapiens_hsa040100.71746453
84Basal cell carcinoma_Homo sapiens_hsa052170.71467243
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71238827
86Endocytosis_Homo sapiens_hsa041440.70884635
87Hippo signaling pathway_Homo sapiens_hsa043900.69947988
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67836339
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67710277
90ECM-receptor interaction_Homo sapiens_hsa045120.67479498
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66101587
92HTLV-I infection_Homo sapiens_hsa051660.66095027
93Vitamin digestion and absorption_Homo sapiens_hsa049770.64316488
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.63768151
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.63613023
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63540490
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61452094
98Ras signaling pathway_Homo sapiens_hsa040140.61447371
99Rap1 signaling pathway_Homo sapiens_hsa040150.59271739
100Renin-angiotensin system_Homo sapiens_hsa046140.58503809
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58329646
102mTOR signaling pathway_Homo sapiens_hsa041500.58262661
103N-Glycan biosynthesis_Homo sapiens_hsa005100.57424504
104Circadian rhythm_Homo sapiens_hsa047100.57356998
105Sphingolipid metabolism_Homo sapiens_hsa006000.57119623
106Platelet activation_Homo sapiens_hsa046110.55927182
107Estrogen signaling pathway_Homo sapiens_hsa049150.55556342
108Nucleotide excision repair_Homo sapiens_hsa034200.54613310
109Renal cell carcinoma_Homo sapiens_hsa052110.54061969
110Hepatitis B_Homo sapiens_hsa051610.52113635
111TNF signaling pathway_Homo sapiens_hsa046680.50832752
112TGF-beta signaling pathway_Homo sapiens_hsa043500.50221160
113Colorectal cancer_Homo sapiens_hsa052100.46943439
114Phototransduction_Homo sapiens_hsa047440.46927015
115Cell cycle_Homo sapiens_hsa041100.46570673
116Choline metabolism in cancer_Homo sapiens_hsa052310.46206406
117Prolactin signaling pathway_Homo sapiens_hsa049170.45550345
118African trypanosomiasis_Homo sapiens_hsa051430.42800888
119Shigellosis_Homo sapiens_hsa051310.42732483
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42558342
121Non-small cell lung cancer_Homo sapiens_hsa052230.42463691
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.42429985
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41434163
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.41083078
125Sulfur metabolism_Homo sapiens_hsa009200.40804915
126Other glycan degradation_Homo sapiens_hsa005110.40540885
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40470635
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40302214
129Inositol phosphate metabolism_Homo sapiens_hsa005620.38286480
130Thyroid hormone synthesis_Homo sapiens_hsa049180.38211791
131Ether lipid metabolism_Homo sapiens_hsa005650.38148712
132Focal adhesion_Homo sapiens_hsa045100.37107028
133Autoimmune thyroid disease_Homo sapiens_hsa053200.36309518
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35854296
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.35580114
136Arachidonic acid metabolism_Homo sapiens_hsa005900.32616494
137Alzheimers disease_Homo sapiens_hsa050100.32218921
138Mineral absorption_Homo sapiens_hsa049780.31887475
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31808382
140Linoleic acid metabolism_Homo sapiens_hsa005910.28864488
141Tight junction_Homo sapiens_hsa045300.28691520
142Alcoholism_Homo sapiens_hsa050340.28526216
143Endometrial cancer_Homo sapiens_hsa052130.28230243
144Adherens junction_Homo sapiens_hsa045200.27642482
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23535304

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