MLF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.90483992
2epithelial cilium movement (GO:0003351)9.42855491
3cilium movement (GO:0003341)9.35211028
4cilium or flagellum-dependent cell motility (GO:0001539)8.92257710
5cell wall macromolecule metabolic process (GO:0044036)8.49558762
6cell wall macromolecule catabolic process (GO:0016998)8.49558762
7fusion of sperm to egg plasma membrane (GO:0007342)8.45777143
8sperm motility (GO:0030317)8.32703193
9motile cilium assembly (GO:0044458)7.53705261
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.41791617
11acrosome assembly (GO:0001675)7.28777874
12sperm-egg recognition (GO:0035036)7.09069231
13acrosome reaction (GO:0007340)6.94481841
14multicellular organism reproduction (GO:0032504)6.92418995
15binding of sperm to zona pellucida (GO:0007339)6.57115634
16plasma membrane fusion (GO:0045026)6.46194524
17regulation of cilium movement (GO:0003352)6.28581969
18cell-cell recognition (GO:0009988)6.28579741
19spermatid development (GO:0007286)5.92321768
20reproduction (GO:0000003)5.87043814
21axoneme assembly (GO:0035082)5.39655961
22negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.38035989
23synaptonemal complex organization (GO:0070193)5.27973894
24actin-myosin filament sliding (GO:0033275)5.21980272
25muscle filament sliding (GO:0030049)5.21980272
26ventricular system development (GO:0021591)5.17590869
27tricarboxylic acid cycle (GO:0006099)5.01215879
28sarcomere organization (GO:0045214)4.98843568
29male meiosis (GO:0007140)4.97635554
30single fertilization (GO:0007338)4.94735316
31sperm capacitation (GO:0048240)4.91902408
32regulation of skeletal muscle contraction (GO:0014819)4.80265350
33piRNA metabolic process (GO:0034587)4.80130098
34positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.78489102
35synaptonemal complex assembly (GO:0007130)4.78305953
36GTP biosynthetic process (GO:0006183)4.68557351
37negative regulation of inclusion body assembly (GO:0090084)4.66523835
38nucleoside diphosphate phosphorylation (GO:0006165)4.64893663
39negative regulation of potassium ion transmembrane transport (GO:1901380)4.62960061
40cardiac myofibril assembly (GO:0055003)4.52207727
41myofibril assembly (GO:0030239)4.43681439
42regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.41588511
43actin-mediated cell contraction (GO:0070252)4.37096043
44intraciliary transport (GO:0042073)4.34318874
45sarcoplasmic reticulum calcium ion transport (GO:0070296)4.17579574
46fertilization (GO:0009566)4.10830452
47UTP biosynthetic process (GO:0006228)4.09335326
48spermatogenesis (GO:0007283)4.08609797
49spermatid nucleus differentiation (GO:0007289)4.08367947
50male gamete generation (GO:0048232)4.07155088
51carnitine transmembrane transport (GO:1902603)3.88538632
52cardiac muscle cell development (GO:0055013)3.85556078
53regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.83786061
54regulation of inclusion body assembly (GO:0090083)3.80382200
55microtubule severing (GO:0051013)3.78903954
56regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.78008932
57regulation of cell communication by electrical coupling (GO:0010649)3.75566340
58UTP metabolic process (GO:0046051)3.75174927
59regulation of sarcomere organization (GO:0060297)3.74139945
60mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.73739285
61gamete generation (GO:0007276)3.73331146
62sequestering of actin monomers (GO:0042989)3.71617986
63carnitine transport (GO:0015879)3.71132006
64amino-acid betaine transport (GO:0015838)3.71132006
65left/right pattern formation (GO:0060972)3.70843299
66carnitine shuttle (GO:0006853)3.70794773
67regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.63548793
68purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.62819754
69cardiac muscle contraction (GO:0060048)3.62146955
70centriole replication (GO:0007099)3.61497597
71regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.60986583
72striated muscle contraction (GO:0006941)3.59952923
73cardiac cell development (GO:0055006)3.59831638
74regulation of relaxation of muscle (GO:1901077)3.56423750
75purine nucleoside triphosphate biosynthetic process (GO:0009145)3.53740426
76cellular component assembly involved in morphogenesis (GO:0010927)3.52585355
77nonmotile primary cilium assembly (GO:0035058)3.46397826
78regulation of microtubule-based movement (GO:0060632)3.46183989
79regulation of acyl-CoA biosynthetic process (GO:0050812)3.44294382
80otic vesicle formation (GO:0030916)3.41910755
81plasma membrane repair (GO:0001778)3.36042871
82establishment of protein localization to mitochondrial membrane (GO:0090151)3.34592592
83cilium organization (GO:0044782)3.34314675
84ATP biosynthetic process (GO:0006754)3.32609012
85left/right axis specification (GO:0070986)3.31742369
86skeletal muscle contraction (GO:0003009)3.31476608
87regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.30706719
88microtubule depolymerization (GO:0007019)3.27514131
89cilium morphogenesis (GO:0060271)3.27424858
90ventricular cardiac muscle cell action potential (GO:0086005)3.26873677
91cellular process involved in reproduction in multicellular organism (GO:0022412)3.26302863
92mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24918645
93ATP synthesis coupled proton transport (GO:0015986)3.23777489
94energy coupled proton transport, down electrochemical gradient (GO:0015985)3.23777489
95actomyosin structure organization (GO:0031032)3.23623799
96germ cell development (GO:0007281)3.22463259
97cilium assembly (GO:0042384)3.18710735
98calcium ion-dependent exocytosis (GO:0017156)3.18328869
99guanosine-containing compound biosynthetic process (GO:1901070)3.18271271
100heart trabecula formation (GO:0060347)3.17268597
101male meiosis I (GO:0007141)3.14840002
102heart contraction (GO:0060047)3.13812862
103heart process (GO:0003015)3.13812862
104glycolytic process (GO:0006096)3.13717105
105ribonucleoside triphosphate biosynthetic process (GO:0009201)3.11355417
106regulation of actin filament-based movement (GO:1903115)3.10945320
107centriole assembly (GO:0098534)3.05475877
108proteasome assembly (GO:0043248)2.96605672
109protein localization to cilium (GO:0061512)2.94259743
110respiratory electron transport chain (GO:0022904)2.77231334
111electron transport chain (GO:0022900)2.75563366
112neuron fate determination (GO:0048664)2.64474142
113smoothened signaling pathway (GO:0007224)2.64161604
114microtubule polymerization or depolymerization (GO:0031109)2.62089339
115cullin deneddylation (GO:0010388)2.56876401
116protein polyglutamylation (GO:0018095)2.56136853
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.52568482
118NADH dehydrogenase complex assembly (GO:0010257)2.52568482
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.52568482
120microtubule-based movement (GO:0007018)2.49534805
121limb bud formation (GO:0060174)2.48999638
122protein complex biogenesis (GO:0070271)2.47760212
123retinal rod cell development (GO:0046548)2.45452531
124microtubule bundle formation (GO:0001578)2.44967003
125presynaptic membrane assembly (GO:0097105)2.44316075
126chromatin remodeling at centromere (GO:0031055)2.41826477
127CENP-A containing nucleosome assembly (GO:0034080)2.39175486
128organelle disassembly (GO:1903008)2.38248124
129resolution of meiotic recombination intermediates (GO:0000712)2.35357753
130mitochondrial respiratory chain complex assembly (GO:0033108)2.32557687
131determination of left/right symmetry (GO:0007368)2.30275197
132synapsis (GO:0007129)2.28932389
133presynaptic membrane organization (GO:0097090)2.26924167
134DNA damage response, detection of DNA damage (GO:0042769)2.26640448
135somite development (GO:0061053)2.26308465
136histone exchange (GO:0043486)2.24170945
137regulation of secondary heart field cardioblast proliferation (GO:0003266)2.23942679
138regulation of cardioblast proliferation (GO:0003264)2.23942679
139determination of bilateral symmetry (GO:0009855)2.23776773
140cell projection assembly (GO:0030031)2.22751342
141retinal ganglion cell axon guidance (GO:0031290)2.22095976
142specification of symmetry (GO:0009799)2.20110486
143notochord development (GO:0030903)2.18741018
144regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.18475202
145protein neddylation (GO:0045116)2.18036634
146negative regulation of transcription regulatory region DNA binding (GO:2000678)2.17005884
147lateral sprouting from an epithelium (GO:0060601)2.16711425
148regulation of meiosis I (GO:0060631)2.16587114
149protein deneddylation (GO:0000338)2.15891100
150appendage development (GO:0048736)2.15429785
151limb development (GO:0060173)2.15429785
152intra-S DNA damage checkpoint (GO:0031573)2.14165541
153neuronal stem cell maintenance (GO:0097150)2.13586162
154negative regulation of oligodendrocyte differentiation (GO:0048715)2.13491019
155oxidative phosphorylation (GO:0006119)2.12839692
156chaperone-mediated protein transport (GO:0072321)2.11569501
157protein refolding (GO:0042026)2.11569163
158chaperone-mediated protein complex assembly (GO:0051131)2.11087202
159regulation of collateral sprouting (GO:0048670)2.04574786
160protein K6-linked ubiquitination (GO:0085020)2.04320790
161photoreceptor cell maintenance (GO:0045494)2.04059931
162ventricular cardiac muscle cell development (GO:0055015)2.01897260
163establishment of planar polarity (GO:0001736)1.99046455
164establishment of tissue polarity (GO:0007164)1.99046455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.39112237
2EZH2_22144423_ChIP-Seq_EOC_Human4.57299352
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.74348443
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.47750475
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.19253497
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.87023274
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85418744
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.57982762
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50695802
10VDR_22108803_ChIP-Seq_LS180_Human2.47670498
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.47464822
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.35473109
13ZNF274_21170338_ChIP-Seq_K562_Hela2.30027987
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.19590236
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19319026
16GBX2_23144817_ChIP-Seq_PC3_Human2.18009266
17EWS_26573619_Chip-Seq_HEK293_Human2.11743172
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10678494
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.05653982
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03508653
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99350319
22P300_19829295_ChIP-Seq_ESCs_Human1.89092776
23ELK1_19687146_ChIP-ChIP_HELA_Human1.88396408
24* TBX20_22328084_ChIP-Seq_HEART_Mouse1.87043536
25* TBX20_22080862_ChIP-Seq_HEART_Mouse1.87043536
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84710083
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83371354
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.82916019
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81217003
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.77517971
31RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.77043723
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73568449
33IGF1R_20145208_ChIP-Seq_DFB_Human1.73406643
34WDR5_24793694_ChIP-Seq_LNCAP_Human1.73040913
35KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.72829096
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.72588754
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.69469820
38* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.63713063
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62176524
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62173313
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51724531
42CBP_20019798_ChIP-Seq_JUKART_Human1.51724531
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.49491606
44* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49463492
45GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.49461872
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.49008862
47* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47209986
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45123910
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44813747
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44813747
51FLI1_21867929_ChIP-Seq_TH2_Mouse1.44071291
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43158010
53MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42966955
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42763275
55TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42014021
56STAT1_17558387_ChIP-Seq_HELA_Human1.40945677
57MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.39586301
58* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39218274
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37515948
60TAF15_26573619_Chip-Seq_HEK293_Human1.37399266
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.36655910
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35843607
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35457924
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35318986
65* TAL1_26923725_Chip-Seq_HPCs_Mouse1.34795563
66MYC_18940864_ChIP-ChIP_HL60_Human1.34673916
67RNF2_27304074_Chip-Seq_NSC_Mouse1.33877944
68* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33541450
69* SMAD3_21741376_ChIP-Seq_EPCs_Human1.33014669
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32810390
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.31211433
72ELK4_26923725_Chip-Seq_MESODERM_Mouse1.30031479
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28961390
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.28819352
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28635457
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27645049
77* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27106416
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.25923971
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25611345
80LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.22514533
81* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21482689
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19219647
83* KDM2B_26808549_Chip-Seq_REH_Human1.19185119
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18869412
85KAP1_22055183_ChIP-Seq_ESCs_Mouse1.18483883
86* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18140235
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18053431
88E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17784973
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17680277
90* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17462587
91ER_23166858_ChIP-Seq_MCF-7_Human1.17396424
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16654140
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16652966
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.16102322
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15647741
96GF1_26923725_Chip-Seq_HPCs_Mouse1.14125548
97NANOG_16153702_ChIP-ChIP_HESCs_Human1.13624419
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13615450
99* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11651304
100BCAT_22108803_ChIP-Seq_LS180_Human1.10676070
101AR_25329375_ChIP-Seq_VCAP_Human1.10480097
102* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10473123
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.10384462
104GATA3_21867929_ChIP-Seq_CD8_Mouse1.08921408
105GATA3_21867929_ChIP-Seq_TH1_Mouse1.08243331
106* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07777010
107EZH2_27304074_Chip-Seq_ESCs_Mouse1.07741177
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07547027
109P53_22387025_ChIP-Seq_ESCs_Mouse1.06572254
110SOX9_26525672_Chip-Seq_HEART_Mouse1.06315251
111FUS_26573619_Chip-Seq_HEK293_Human1.05755793
112TCF4_22108803_ChIP-Seq_LS180_Human1.05416643
113SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05364108
114SMAD4_21799915_ChIP-Seq_A2780_Human1.05203702
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05181103
116GF1B_26923725_Chip-Seq_HPCs_Mouse1.05024536
117* SMAD4_21741376_ChIP-Seq_EPCs_Human1.03874960
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.03108592
119* P53_21459846_ChIP-Seq_SAOS-2_Human1.02942784
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02103086
121SOX2_19829295_ChIP-Seq_ESCs_Human1.01918714
122NANOG_19829295_ChIP-Seq_ESCs_Human1.01918714
123* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01697580
124ETS1_20019798_ChIP-Seq_JURKAT_Human1.01530065
125VDR_23849224_ChIP-Seq_CD4+_Human1.01341796
126PHF8_20622853_ChIP-Seq_HELA_Human1.01265104
127OCT4_18555785_Chip-Seq_ESCs_Mouse1.01101141
128OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00512068
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00488522
130ERG_20517297_ChIP-Seq_VCAP_Human1.00375043
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00233913
132SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00043205
133* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99986084
134RUNX2_22187159_ChIP-Seq_PCA_Human0.99647213
135SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98508569
136* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98504954
137STAT3_23295773_ChIP-Seq_U87_Human0.98354176
138NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98105917
139NFYB_21822215_ChIP-Seq_K562_Human0.97579543
140FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97578907
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97364948
142FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95364489
143* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95360924
144AR_21572438_ChIP-Seq_LNCaP_Human0.94572016
145JUN_21703547_ChIP-Seq_K562_Human0.93815010
146EED_16625203_ChIP-ChIP_MESCs_Mouse0.93696653
147ETV1_20927104_ChIP-Seq_GIST48_Human0.93474773
148SOX2_18555785_Chip-Seq_ESCs_Mouse0.93419659
149JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93410816
150STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93017557
151TBL1_22424771_ChIP-Seq_293T_Human0.92973370
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92638164
153EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91359994
154STAT3_18555785_Chip-Seq_ESCs_Mouse0.90923780
155* NANOG_20526341_ChIP-Seq_ESCs_Human0.90664583
156SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90563507
157CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90334159
158IRF1_19129219_ChIP-ChIP_H3396_Human0.90073736
159* E2F1_18555785_Chip-Seq_ESCs_Mouse0.89586247
160CMYC_18555785_Chip-Seq_ESCs_Mouse0.88797621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.18412441
2MP0003646_muscle_fatigue5.83757439
3MP0000751_myopathy4.47031784
4MP0004084_abnormal_cardiac_muscle4.19294130
5MP0004036_abnormal_muscle_relaxation3.90075332
6MP0004145_abnormal_muscle_electrophysio3.89401393
7MP0002837_dystrophic_cardiac_calcinosis3.89047745
8MP0000749_muscle_degeneration3.83034030
9MP0004215_abnormal_myocardial_fiber3.34414581
10MP0003698_abnormal_male_reproductive2.85323350
11MP0005330_cardiomyopathy2.65071467
12MP0002106_abnormal_muscle_physiology2.64130259
13MP0004087_abnormal_muscle_fiber2.62350601
14MP0001929_abnormal_gametogenesis2.56302597
15MP0005620_abnormal_muscle_contractility2.47986910
16MP0004233_abnormal_muscle_weight2.34892039
17MP0000750_abnormal_muscle_regeneration2.28374882
18MP0004484_altered_response_of2.21097322
19MP0002269_muscular_atrophy2.16893817
20MP0002972_abnormal_cardiac_muscle2.16458242
21MP0004130_abnormal_muscle_cell2.12486517
22MP0005369_muscle_phenotype2.11733057
23MP0001529_abnormal_vocalization2.05782332
24MP0005623_abnormal_meninges_morphology2.04965346
25MP0002638_abnormal_pupillary_reflex2.04343033
26MP0008877_abnormal_DNA_methylation2.03475656
27MP0003880_abnormal_central_pattern2.00712811
28MP0003137_abnormal_impulse_conducting1.97437435
29MP0008775_abnormal_heart_ventricle1.95037717
30MP0000759_abnormal_skeletal_muscle1.93016589
31MP0000747_muscle_weakness1.88792421
32MP0010030_abnormal_orbit_morphology1.86761391
33MP0006036_abnormal_mitochondrial_physio1.81265879
34MP0003890_abnormal_embryonic-extraembry1.78527084
35MP0001544_abnormal_cardiovascular_syste1.77419949
36MP0005385_cardiovascular_system_phenoty1.77419949
37MP0010630_abnormal_cardiac_muscle1.74671802
38MP0002210_abnormal_sex_determination1.72960127
39MP0001984_abnormal_olfaction1.71821493
40MP0000566_synostosis1.64232569
41MP0003950_abnormal_plasma_membrane1.63148674
42MP0002653_abnormal_ependyma_morphology1.61253875
43MP0000778_abnormal_nervous_system1.59941002
44MP0002234_abnormal_pharynx_morphology1.56450175
45MP0002938_white_spotting1.54501057
46MP0006138_congestive_heart_failure1.51251398
47MP0003221_abnormal_cardiomyocyte_apopto1.47980773
48MP0006292_abnormal_olfactory_placode1.47929686
49MP0002161_abnormal_fertility/fecundity1.45269583
50MP0002127_abnormal_cardiovascular_syste1.43377446
51MP0004085_abnormal_heartbeat1.42829582
52MP0003937_abnormal_limbs/digits/tail_de1.41048603
53MP0005670_abnormal_white_adipose1.40530230
54MP0006072_abnormal_retinal_apoptosis1.39719548
55MP0002332_abnormal_exercise_endurance1.38270885
56MP0006276_abnormal_autonomic_nervous1.32247071
57MP0000631_abnormal_neuroendocrine_gland1.32044680
58MP0003122_maternal_imprinting1.31623115
59MP0005377_hearing/vestibular/ear_phenot1.30399387
60MP0003878_abnormal_ear_physiology1.30399387
61MP0001145_abnormal_male_reproductive1.29720434
62MP0003718_maternal_effect1.28323146
63MP0005253_abnormal_eye_physiology1.28066181
64MP0002822_catalepsy1.26377331
65MP0003941_abnormal_skin_development1.24878950
66MP0002160_abnormal_reproductive_system1.23776326
67MP0003119_abnormal_digestive_system1.18313686
68MP0000026_abnormal_inner_ear1.16696674
69MP0003121_genomic_imprinting1.15073631
70MP0002282_abnormal_trachea_morphology1.14352034
71MP0005423_abnormal_somatic_nervous1.13651741
72MP0000653_abnormal_sex_gland1.13071424
73MP0002734_abnormal_mechanical_nocicepti1.12644210
74MP0005084_abnormal_gallbladder_morpholo1.11436687
75MP0001286_abnormal_eye_development1.10020853
76MP0003828_pulmonary_edema1.09283067
77MP0006035_abnormal_mitochondrial_morpho1.06841127
78MP0002108_abnormal_muscle_morphology1.06309583
79MP0003755_abnormal_palate_morphology1.04113847
80MP0001299_abnormal_eye_distance/1.03956263
81MP0001486_abnormal_startle_reflex1.03631168
82MP0003011_delayed_dark_adaptation1.03091121
83MP0005551_abnormal_eye_electrophysiolog1.03008342
84MP0004142_abnormal_muscle_tone1.02527602
85MP0008932_abnormal_embryonic_tissue1.02259570
86MP0003136_yellow_coat_color1.00468229
87MP0002277_abnormal_respiratory_mucosa0.98233646
88MP0000647_abnormal_sebaceous_gland0.97645774
89MP0000955_abnormal_spinal_cord0.97630724
90MP0005666_abnormal_adipose_tissue0.96238446
91MP0002697_abnormal_eye_size0.94597436
92MP0009379_abnormal_foot_pigmentation0.94406452
93MP0001346_abnormal_lacrimal_gland0.94183660
94MP0005391_vision/eye_phenotype0.93840836
95MP0002272_abnormal_nervous_system0.93456734
96MP0002751_abnormal_autonomic_nervous0.93376982
97MP0004270_analgesia0.92669949
98MP0003861_abnormal_nervous_system0.91587179
99MP0009046_muscle_twitch0.91270100
100MP0009745_abnormal_behavioral_response0.90347457
101MP0002752_abnormal_somatic_nervous0.90064518
102MP0005171_absent_coat_pigmentation0.87573967
103MP0000762_abnormal_tongue_morphology0.84318092
104MP0002557_abnormal_social/conspecific_i0.83924994
105MP0005248_abnormal_Harderian_gland0.83005104
106MP0003938_abnormal_ear_development0.82328104
107MP0002184_abnormal_innervation0.81784182
108MP0002572_abnormal_emotion/affect_behav0.81765192
109MP0000266_abnormal_heart_morphology0.81720523
110MP0009250_abnormal_appendicular_skeleto0.79762174
111MP0003567_abnormal_fetal_cardiomyocyte0.79602510
112MP0008875_abnormal_xenobiotic_pharmacok0.79517052
113MP0008789_abnormal_olfactory_epithelium0.79273608
114MP0002736_abnormal_nociception_after0.78689315
115MP0002249_abnormal_larynx_morphology0.78251679
116MP0005195_abnormal_posterior_eye0.77515529
117MP0001502_abnormal_circadian_rhythm0.76244079
118MP0005266_abnormal_metabolism0.75344015
119MP0002971_abnormal_brown_adipose0.71428242
120MP0000733_abnormal_muscle_development0.69724418
121MP0008995_early_reproductive_senescence0.62397759
122MP0008004_abnormal_stomach_pH0.61464842
123MP0000343_altered_response_to0.57727550
124MP0000372_irregular_coat_pigmentation0.57466643
125MP0004133_heterotaxia0.57194408
126MP0005165_increased_susceptibility_to0.53322414
127MP0004134_abnormal_chest_morphology0.52643281
128MP0001485_abnormal_pinna_reflex0.50715301
129MP0004043_abnormal_pH_regulation0.49803464
130MP0005646_abnormal_pituitary_gland0.48928447
131MP0005375_adipose_tissue_phenotype0.48563924
132MP0001765_abnormal_ion_homeostasis0.47716627
133MP0005647_abnormal_sex_gland0.46149504
134MP0001727_abnormal_embryo_implantation0.45558878
135MP0003279_aneurysm0.45227853
136MP0002128_abnormal_blood_circulation0.44829196
137MP0001293_anophthalmia0.44695655
138MP0005389_reproductive_system_phenotype0.42598707
139MP0009384_cardiac_valve_regurgitation0.42345395
140MP0002102_abnormal_ear_morphology0.41666262
141MP0003948_abnormal_gas_homeostasis0.40209443
142MP0009115_abnormal_fat_cell0.38582157
143MP0005394_taste/olfaction_phenotype0.38438916
144MP0005499_abnormal_olfactory_system0.38438916
145MP0005187_abnormal_penis_morphology0.37512135
146MP0002896_abnormal_bone_mineralization0.36518469
147MP0001879_abnormal_lymphatic_vessel0.34801155
148MP0000230_abnormal_systemic_arterial0.34511030
149MP0000049_abnormal_middle_ear0.32146055
150MP0003942_abnormal_urinary_system0.31983206
151MP0002928_abnormal_bile_duct0.31548070
152MP0004510_myositis0.31502227
153MP0005388_respiratory_system_phenotype0.31332714
154MP0002133_abnormal_respiratory_system0.31332714
155MP0002233_abnormal_nose_morphology0.30646409
156MP0001784_abnormal_fluid_regulation0.28865789
157MP0008058_abnormal_DNA_repair0.26528908
158MP0005275_abnormal_skin_tensile0.24518894

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.83783686
2Abnormal respiratory motile cilium physiology (HP:0012261)8.37678917
3Absent/shortened dynein arms (HP:0200106)8.27492281
4Dynein arm defect of respiratory motile cilia (HP:0012255)8.27492281
5Abnormal ciliary motility (HP:0012262)7.59420220
6Abnormal respiratory epithelium morphology (HP:0012253)7.33108939
7Abnormal respiratory motile cilium morphology (HP:0005938)7.33108939
8Rhinitis (HP:0012384)6.80855924
9Exercise-induced myalgia (HP:0003738)5.44224030
10Chronic bronchitis (HP:0004469)5.27497367
11Exercise-induced muscle cramps (HP:0003710)4.92434309
12Muscle hypertrophy of the lower extremities (HP:0008968)4.23986008
13Calf muscle hypertrophy (HP:0008981)4.23542677
14Sudden death (HP:0001699)4.18147023
15Myoglobinuria (HP:0002913)3.90615918
16Nasal polyposis (HP:0100582)3.82040004
17Muscle fiber inclusion bodies (HP:0100299)3.75704858
18Muscle fiber splitting (HP:0003555)3.70861575
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.61285540
20Bronchiectasis (HP:0002110)3.58616336
21Hyporeflexia of lower limbs (HP:0002600)3.57831514
22Infertility (HP:0000789)3.56936181
23Pancreatic cysts (HP:0001737)3.54909364
24Ventricular tachycardia (HP:0004756)3.45025568
25Abnormality of the calf musculature (HP:0001430)3.35530725
26Abnormality of the nasal mucosa (HP:0000433)3.23922721
27Nemaline bodies (HP:0003798)3.23848220
28Rhabdomyolysis (HP:0003201)3.21660050
29Subaortic stenosis (HP:0001682)3.17845762
30Abnormality of the left ventricular outflow tract (HP:0011103)3.17845762
31Asymmetric septal hypertrophy (HP:0001670)3.15770954
32Atrial fibrillation (HP:0005110)3.03073401
33Type 1 muscle fiber predominance (HP:0003803)2.90636171
34Bundle branch block (HP:0011710)2.88422274
35Nephrogenic diabetes insipidus (HP:0009806)2.85697666
36Primary atrial arrhythmia (HP:0001692)2.84233025
37Difficulty running (HP:0009046)2.81612996
38Nephronophthisis (HP:0000090)2.81154939
39Male infertility (HP:0003251)2.73716869
40Supraventricular tachycardia (HP:0004755)2.70132833
41Bronchitis (HP:0012387)2.69160892
42Lipoatrophy (HP:0100578)2.67216083
43Syncope (HP:0001279)2.64911409
44Genital tract atresia (HP:0001827)2.64511071
45Supraventricular arrhythmia (HP:0005115)2.63278560
46Vaginal atresia (HP:0000148)2.63159498
47Palpitations (HP:0001962)2.62321966
48EMG: myopathic abnormalities (HP:0003458)2.60751329
49Sclerocornea (HP:0000647)2.57975029
50Chronic hepatic failure (HP:0100626)2.57821006
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.56080366
52Left ventricular hypertrophy (HP:0001712)2.44106847
53Muscle stiffness (HP:0003552)2.40416701
54Poor coordination (HP:0002370)2.37746371
55Anencephaly (HP:0002323)2.36085730
56Recurrent sinusitis (HP:0011108)2.34584446
57Median cleft lip (HP:0000161)2.34115722
58Tubulointerstitial nephritis (HP:0001970)2.34093029
59Postaxial hand polydactyly (HP:0001162)2.32414141
60Increased connective tissue (HP:0009025)2.32301236
61Prolonged QT interval (HP:0001657)2.31941738
62Dilated cardiomyopathy (HP:0001644)2.26247269
63Medial flaring of the eyebrow (HP:0010747)2.26034788
64Pancreatic fibrosis (HP:0100732)2.24567342
65Right ventricular cardiomyopathy (HP:0011663)2.24438886
66Myotonia (HP:0002486)2.23930344
67Molar tooth sign on MRI (HP:0002419)2.23698496
68Abnormality of midbrain morphology (HP:0002418)2.23698496
69Distal arthrogryposis (HP:0005684)2.22909110
70Acute necrotizing encephalopathy (HP:0006965)2.22667968
71Septo-optic dysplasia (HP:0100842)2.20950898
72Male pseudohermaphroditism (HP:0000037)2.19254767
73Preaxial hand polydactyly (HP:0001177)2.14753156
74Difficulty climbing stairs (HP:0003551)2.13053694
75Ventricular arrhythmia (HP:0004308)2.12462092
76Abnormal mitochondria in muscle tissue (HP:0008316)2.12450039
77Mitochondrial inheritance (HP:0001427)2.11116825
78Abnormality of the labia minora (HP:0012880)2.09743978
79True hermaphroditism (HP:0010459)2.09236855
80Heart block (HP:0012722)2.07221362
81Tubular atrophy (HP:0000092)2.06279373
82Rimmed vacuoles (HP:0003805)2.05849528
83Ventricular fibrillation (HP:0001663)2.02805844
84Oligodactyly (hands) (HP:0001180)2.02421500
85Abnormality of the renal medulla (HP:0100957)2.01941795
86Oculomotor apraxia (HP:0000657)2.00581410
87Increased hepatocellular lipid droplets (HP:0006565)1.96993797
88Anophthalmia (HP:0000528)1.96510825
89Ulnar deviation of the wrist (HP:0003049)1.96274420
90Increased variability in muscle fiber diameter (HP:0003557)1.94761238
91Abnormal atrioventricular conduction (HP:0005150)1.94755406
92Abnormality of dentin (HP:0010299)1.89603045
93Exercise intolerance (HP:0003546)1.89535318
94Abnormality of skeletal muscle fiber size (HP:0012084)1.89382401
95Areflexia of lower limbs (HP:0002522)1.89174479
96Recurrent otitis media (HP:0000403)1.88058579
97Increased CSF lactate (HP:0002490)1.86600222
98Progressive macrocephaly (HP:0004481)1.86503240
99Myopathic facies (HP:0002058)1.82892226
100Round ear (HP:0100830)1.81235058
101Central scotoma (HP:0000603)1.80422349
102Neck muscle weakness (HP:0000467)1.79379746
103Maternal diabetes (HP:0009800)1.78898729
104Acute encephalopathy (HP:0006846)1.77681099
105Lipid accumulation in hepatocytes (HP:0006561)1.77612916
106Chronic sinusitis (HP:0011109)1.77311130
107Congenital hepatic fibrosis (HP:0002612)1.77011333
108Absent septum pellucidum (HP:0001331)1.74812301
109Congenital primary aphakia (HP:0007707)1.74800524
110Esophageal atresia (HP:0002032)1.74161255
111Aganglionic megacolon (HP:0002251)1.73634224
112Specific learning disability (HP:0001328)1.73098500
113Broad foot (HP:0001769)1.73013661
114Gait imbalance (HP:0002141)1.72397561
115Furrowed tongue (HP:0000221)1.72268007
116Generalized muscle weakness (HP:0003324)1.71458265
117Increased serum pyruvate (HP:0003542)1.69340528
118Bifid tongue (HP:0010297)1.67529131
119Abnormal EKG (HP:0003115)1.66397312
120Occipital encephalocele (HP:0002085)1.65337747
121Bell-shaped thorax (HP:0001591)1.64511718
122Aplasia/Hypoplasia of the lens (HP:0008063)1.64409545
123Hypoplastic ischia (HP:0003175)1.64008508
124Tubulointerstitial abnormality (HP:0001969)1.63694298
125Optic nerve hypoplasia (HP:0000609)1.63450792
126Narrow forehead (HP:0000341)1.62652780
127Congenital malformation of the right heart (HP:0011723)1.61975949
128Double outlet right ventricle (HP:0001719)1.61975949
129Cerebral edema (HP:0002181)1.61920100
130Gastrointestinal atresia (HP:0002589)1.61793054
131Gowers sign (HP:0003391)1.61490237
132Abnormality of the renal cortex (HP:0011035)1.59417047
133Decreased testicular size (HP:0008734)1.59384283
134Neoplasm of head and neck (HP:0012288)1.58627378
135Esophageal neoplasm (HP:0100751)1.58627378
136Postaxial foot polydactyly (HP:0001830)1.57523999
137Bile duct proliferation (HP:0001408)1.57131819
138Abnormal biliary tract physiology (HP:0012439)1.57131819
139Supernumerary spleens (HP:0009799)1.56456798
140Cystic liver disease (HP:0006706)1.56157930
141Renal Fanconi syndrome (HP:0001994)1.55893860
142Hepatocellular necrosis (HP:0001404)1.55305868
143Pheochromocytoma (HP:0002666)1.53807118
144Type II lissencephaly (HP:0007260)1.53286575
145Prominent nasal bridge (HP:0000426)1.52437838
146Neuroendocrine neoplasm (HP:0100634)1.51287141
147Multicystic kidney dysplasia (HP:0000003)1.49868564
148Split foot (HP:0001839)1.49836577
149Abnormality of glycolysis (HP:0004366)1.49319315
150Optic disc pallor (HP:0000543)1.48530180
151Hyperglycinemia (HP:0002154)1.46392058
152Stenosis of the external auditory canal (HP:0000402)1.44758996
153Abnormality of the septum pellucidum (HP:0007375)1.44739864
154Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.44188970
155Oligodactyly (HP:0012165)1.44157604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.78610188
2PDK37.78610188
3PDK25.06899154
4OBSCN3.80454785
5TTN3.47816999
6PHKG13.20691215
7PHKG23.20691215
8TSSK62.88209361
9MST42.60337325
10CASK2.42870294
11TESK12.36461509
12TNIK2.34901398
13TRIM282.18006278
14MAPK152.13875614
15PRKD32.02410440
16STK242.00297966
17BCR1.90628702
18BMPR1B1.89085907
19PNCK1.84796290
20VRK11.79521664
21LMTK21.76757028
22PBK1.73289548
23WNK31.67282437
24ICK1.67092683
25WNK41.63190863
26BUB11.61462090
27PINK11.58268654
28MAP4K21.53979928
29STK391.51009366
30PTK2B1.42970172
31MKNK21.40860118
32STK161.39384571
33PLK31.39090359
34MYLK1.38922071
35VRK21.38671364
36MUSK1.35784334
37SRPK11.32710247
38DMPK1.28522456
39NEK11.22007144
40MARK11.21470064
41PLK21.21365369
42DYRK21.19495675
43EIF2AK31.09397232
44MKNK11.07762554
45STK38L1.07109083
46MAPKAPK31.04940846
47NTRK21.00407037
48MAP3K120.98157894
49EPHB20.97261695
50NUAK10.96903009
51PIK3CG0.95475235
52PLK10.94362768
53TRIB30.94123340
54CDC70.91487027
55DYRK30.91026117
56TIE10.88936882
57CDK190.85014059
58EPHA40.82614528
59CSNK1G20.78092821
60STK380.77400657
61TGFBR10.75865016
62TRPM70.75775429
63PKN20.74996331
64EEF2K0.74817828
65ERBB30.74770603
66BRSK10.74385518
67NME10.73424428
68DYRK1B0.71722691
69CAMK2D0.71495942
70MAPK120.71135969
71PIK3CA0.70962906
72ZAK0.68003214
73CSNK1G10.67857976
74PRKCE0.62743481
75WNK10.62566883
76PRKAA10.61305809
77CCNB10.60879835
78MAP3K30.60389493
79PDK10.59968176
80FGFR20.59601528
81EPHA30.58671439
82RIPK10.57940925
83OXSR10.57777702
84MINK10.57496315
85PRKAA20.57408940
86MET0.57329744
87TAF10.57136540
88ILK0.56362364
89PASK0.56049404
90MAP2K60.53681375
91CSNK1G30.53600790
92FRK0.52411855
93ACVR1B0.50529283
94EPHA20.50109907
95GRK70.50061544
96BCKDK0.48301867
97CDC42BPA0.46286207
98CDK80.45056730
99ROCK10.45009192
100IRAK10.43506678
101CAMK2G0.42836274
102MAP2K30.42035454
103NEK90.42011162
104MAP3K50.41982997
105LIMK10.40740442
106KSR10.40018695
107MAP3K100.39737344
108ERBB40.39600705
109FGFR10.39148432
110DYRK1A0.39024017
111RPS6KA40.37929625
112EIF2AK20.37810191
113MAP2K40.37781648
114LATS10.37615833
115ADRBK20.37278915
116EIF2AK10.37215811
117WEE10.36982631
118CSNK1A1L0.36859691
119PAK30.36576046
120TAOK20.35885322
121MAP3K70.35818131
122CSNK1E0.35418354
123CAMK2A0.35223904
124PRPF4B0.35093049
125PRKD10.33331402
126PLK40.30301205
127PKN10.29959049
128MAP3K40.25641579
129PRKACA0.25637663
130AKT20.24723026
131PDPK10.24566304
132PRKACB0.23519465
133GRK10.23172152
134PRKG10.21868556
135MAPK130.21703045
136NEK20.21563623
137MAP2K70.21299474
138TYRO30.20140107
139PRKG20.19439471
140STK30.19088620
141RPS6KA10.18758729
142PRKACG0.18209112
143BRSK20.16920091
144CAMK40.16538643
145CDK30.13921988
146CAMK2B0.12702195
147TTK0.12137908
148AURKA0.10705949
149PRKCG0.10496782
150CAMK10.09872519
151MAPK70.09582651
152PRKCQ0.09205227
153RPS6KA20.08329878
154PAK20.07866183
155MAPKAPK20.07700992
156MAPKAPK50.07037893
157INSRR0.06920102
158ROCK20.06484194
159MARK30.06002854

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.25154820
2Cardiac muscle contraction_Homo sapiens_hsa042604.29269234
3Propanoate metabolism_Homo sapiens_hsa006403.97629965
4Huntingtons disease_Homo sapiens_hsa050163.44442751
5Parkinsons disease_Homo sapiens_hsa050123.43702234
6Oxidative phosphorylation_Homo sapiens_hsa001903.28635526
7Pyruvate metabolism_Homo sapiens_hsa006203.21915970
8Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.89280544
9Protein export_Homo sapiens_hsa030602.80338738
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.78451499
11Dilated cardiomyopathy_Homo sapiens_hsa054142.60517611
12Alzheimers disease_Homo sapiens_hsa050102.54351067
13Carbon metabolism_Homo sapiens_hsa012002.35701400
14Glucagon signaling pathway_Homo sapiens_hsa049222.22614006
15Proteasome_Homo sapiens_hsa030502.20413650
16Fatty acid degradation_Homo sapiens_hsa000712.16824360
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.13010505
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10762643
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09835121
20Ribosome_Homo sapiens_hsa030102.09708246
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86617261
22Steroid biosynthesis_Homo sapiens_hsa001001.85134081
23RNA polymerase_Homo sapiens_hsa030201.82940122
24Mismatch repair_Homo sapiens_hsa034301.72487064
25Fatty acid biosynthesis_Homo sapiens_hsa000611.56672021
26Homologous recombination_Homo sapiens_hsa034401.56080151
27Fatty acid metabolism_Homo sapiens_hsa012121.54966436
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53530851
29Olfactory transduction_Homo sapiens_hsa047401.43072896
30Vitamin B6 metabolism_Homo sapiens_hsa007501.36650545
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35314000
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34330939
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.31228209
34Nucleotide excision repair_Homo sapiens_hsa034201.26393235
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24572283
36Calcium signaling pathway_Homo sapiens_hsa040201.23160261
37RNA transport_Homo sapiens_hsa030131.17634121
38Phototransduction_Homo sapiens_hsa047441.17283065
39PPAR signaling pathway_Homo sapiens_hsa033201.13585361
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13037181
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12201560
42Nicotine addiction_Homo sapiens_hsa050331.11661565
43Spliceosome_Homo sapiens_hsa030401.07817342
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06804330
45Folate biosynthesis_Homo sapiens_hsa007901.06188285
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05253680
47Linoleic acid metabolism_Homo sapiens_hsa005911.03175646
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01325861
49Viral myocarditis_Homo sapiens_hsa054161.00234154
50beta-Alanine metabolism_Homo sapiens_hsa004100.97639126
51Non-homologous end-joining_Homo sapiens_hsa034500.93973778
52Insulin resistance_Homo sapiens_hsa049310.93702105
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92423516
54DNA replication_Homo sapiens_hsa030300.91651277
55Biosynthesis of amino acids_Homo sapiens_hsa012300.90764591
56Starch and sucrose metabolism_Homo sapiens_hsa005000.90065236
57Insulin signaling pathway_Homo sapiens_hsa049100.89366428
58Nitrogen metabolism_Homo sapiens_hsa009100.89102902
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.87628662
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.86227931
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85840876
62Base excision repair_Homo sapiens_hsa034100.85789342
63Purine metabolism_Homo sapiens_hsa002300.84202662
64Oxytocin signaling pathway_Homo sapiens_hsa049210.84045327
65Basal transcription factors_Homo sapiens_hsa030220.83361352
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83103765
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82943604
68Hippo signaling pathway_Homo sapiens_hsa043900.82902582
69Renin secretion_Homo sapiens_hsa049240.82706071
70AMPK signaling pathway_Homo sapiens_hsa041520.79999930
71Oocyte meiosis_Homo sapiens_hsa041140.77163061
72Chemical carcinogenesis_Homo sapiens_hsa052040.75339405
73Insulin secretion_Homo sapiens_hsa049110.72174297
74Phenylalanine metabolism_Homo sapiens_hsa003600.71960945
75Tight junction_Homo sapiens_hsa045300.71687541
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71386963
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.71371176
78Pyrimidine metabolism_Homo sapiens_hsa002400.70796795
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69465528
80Cell cycle_Homo sapiens_hsa041100.69226041
81Cocaine addiction_Homo sapiens_hsa050300.69160721
82Dorso-ventral axis formation_Homo sapiens_hsa043200.69144758
83Regulation of autophagy_Homo sapiens_hsa041400.68853757
84Gastric acid secretion_Homo sapiens_hsa049710.66985999
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66233057
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.65850759
87Fructose and mannose metabolism_Homo sapiens_hsa000510.64949719
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63773540
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63408912
90Circadian rhythm_Homo sapiens_hsa047100.61837455
91Butanoate metabolism_Homo sapiens_hsa006500.61605122
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61399406
93Tyrosine metabolism_Homo sapiens_hsa003500.61237058
94GABAergic synapse_Homo sapiens_hsa047270.57350825
95Axon guidance_Homo sapiens_hsa043600.57163932
96Wnt signaling pathway_Homo sapiens_hsa043100.56633655
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56110887
98Fatty acid elongation_Homo sapiens_hsa000620.55924878
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55699202
100Sulfur metabolism_Homo sapiens_hsa009200.55639945
101TGF-beta signaling pathway_Homo sapiens_hsa043500.54200916
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53782813
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53115255
104Collecting duct acid secretion_Homo sapiens_hsa049660.52192462
105Metabolic pathways_Homo sapiens_hsa011000.51247889
106Caffeine metabolism_Homo sapiens_hsa002320.49764971
107Fanconi anemia pathway_Homo sapiens_hsa034600.49305256
108Pentose phosphate pathway_Homo sapiens_hsa000300.48305499
109One carbon pool by folate_Homo sapiens_hsa006700.46900333
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46821339
111Glycerolipid metabolism_Homo sapiens_hsa005610.46238374
112Retinol metabolism_Homo sapiens_hsa008300.46068625
113cAMP signaling pathway_Homo sapiens_hsa040240.45229105
114Amphetamine addiction_Homo sapiens_hsa050310.45076209
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.44769089
116Arachidonic acid metabolism_Homo sapiens_hsa005900.44227452
117Tryptophan metabolism_Homo sapiens_hsa003800.44150623
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43676307
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.42993678
120Circadian entrainment_Homo sapiens_hsa047130.42056157
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41603689
122HIF-1 signaling pathway_Homo sapiens_hsa040660.41495879
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41350003
124Ovarian steroidogenesis_Homo sapiens_hsa049130.40176260
125Glutathione metabolism_Homo sapiens_hsa004800.37019615
126Focal adhesion_Homo sapiens_hsa045100.35948541
127Selenocompound metabolism_Homo sapiens_hsa004500.35617626
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34443866
129Hedgehog signaling pathway_Homo sapiens_hsa043400.31997046
130Ether lipid metabolism_Homo sapiens_hsa005650.31949757
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29662040
132Mineral absorption_Homo sapiens_hsa049780.29612226
133mRNA surveillance pathway_Homo sapiens_hsa030150.29028830
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28923835
135Galactose metabolism_Homo sapiens_hsa000520.26596781
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.24698829
137RNA degradation_Homo sapiens_hsa030180.23814806
138Taste transduction_Homo sapiens_hsa047420.21577094
139Arginine and proline metabolism_Homo sapiens_hsa003300.21348823
140Estrogen signaling pathway_Homo sapiens_hsa049150.20109882
141Fat digestion and absorption_Homo sapiens_hsa049750.19599757
142ECM-receptor interaction_Homo sapiens_hsa045120.19580631
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16467058
144Protein digestion and absorption_Homo sapiens_hsa049740.16130713
145Pancreatic secretion_Homo sapiens_hsa049720.15703594
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15676233
147Peroxisome_Homo sapiens_hsa041460.14432459
148Basal cell carcinoma_Homo sapiens_hsa052170.14289247
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12988582
150Inositol phosphate metabolism_Homo sapiens_hsa005620.12297071

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